Publications

ANTMAN, K, SHEMIN, R, RYAN, L, KLEGAR, K, OSTEEN, R, HERMAN, T, LEDERMAN, G & CORSON, J 1988, 'MALIGNANT MESOTHELIOMA - PROGNOSTIC VARIABLES IN A REGISTRY OF 180 PATIENTS, THE DANA-FARBER-CANCER-INSTITUTE AND BRIGHAM-AND-WOMENS-HOSPITAL EXPERIENCE OVER 2 DECADES, 1965-1985', JOURNAL OF CLINICAL ONCOLOGY, vol. 6, no. 1, pp. 147-153.
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ANTMAN, KS, GRIFFIN, JD, ELIAS, A, SOCINSKI, MA, RYAN, L, CANNISTRA, SA, OETTE, D, WHITLEY, M, FREI, E & SCHNIPPER, LE 1988, 'EFFECT OF RECOMBINANT HUMAN GRANULOCYTE MACROPHAGE COLONY-STIMULATING FACTOR ON CHEMOTHERAPY-INDUCED MYELOSUPPRESSION', NEW ENGLAND JOURNAL OF MEDICINE, vol. 319, no. 10, pp. 593-598.
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FALKSON, G, CNAAN, A, SCHUTT, AJ, RYAN, LM & FALKSON, HC 1988, 'PROGNOSTIC FACTORS FOR SURVIVAL IN HEPATOCELLULAR-CARCINOMA', CANCER RESEARCH, vol. 48, no. 24, pp. 7314-7318.
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Associations between patient characteristics and survival were investigated in 432 patients with hepatocellular carcinoma. Those patients were prospectively studied by the Eastern Cooperative Oncology Group, and each had his or her diagnosis reconfirmed by a pathology review panel. There were 301 North American and 131 South African patients. Sixty-nine % of the North American patients and 82% of the South African patients were male. There were 187 Black patients, 62 of whom were from North America. The study population is unique among hepatocellular carcinoma patients in that eligibility, evaluability, and endpoint definitions were standardized, and patients from both North America and South Africa received similar treatments at a similar time. Factors with the most significant adverse effect on survival are impaired performance status, male sex, older age, and disease symptoms (jaundice and reduced appetite). There is no apparent difference in survival between White and Black patients within North America, but North American patients survived longer than South African patients. Among the different therapies, p.o. 5-fluorouracil was associated with the poorest median survival time (6 wk), and i.v. 5-fluorouracil plus semustine with the best median survival time (24 wk). © 1988, American Association for Cancer Research. All rights reserved.

RYAN, LM & ORAV, EJ 1988, 'ON THE USE OF COVARIATES FOR RODENT BIOASSAY AND SCREENING EXPERIMENTS', BIOMETRIKA, vol. 75, no. 4, pp. 631-637.
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Consider a three-state compartmental model with an initial, an absorbing and an intermediate state which may or may not be entered before absorption. Observable data are time to absorption and an indication of whether the intermediate state was entered, but not the time of transition. The transition rates characterizing the process are nonidentifiable without simplifying assumptions or additional information on the prevalence function, defined as the time specific proportion of nonabsorbed individuals in the intermediate state. Our approach makes prevalence identifiable and easily estimable through the use of covariates, combined with one or more random screens of the population. The results are illustrated with pathology data from a rodent tumourigenicity experiment involving several random sacrifices. © 1988 Biometrika Trust.

SIEGEL, RD, RYAN, LM & ANTMAN, KH 1988, 'ADULTS WITH EWINGS-SARCOMA - AN ANALYSIS OF 16 PATIENTS AT THE DANA-FARBER-CANCER-INSTITUTE', AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS, vol. 11, no. 6, pp. 614-617.
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