Dua, K, Ramana, M, Singh Sara, U, Himaja, M, Agrawal, A, Garg, V & Pabreja, K 2007, 'Investigation of Enhancement of Solubility of Norfloxacin β-Cyclodextrin in Presence of Acidic Solubilizing Additives', Current Drug Delivery, vol. 4, no. 1, pp. 21-25.
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The present study is aimed at improving the solubility of a poorly water-soluble drug, norfloxacin by incorporating solubilizing additives such as ascorbic acid and citric acid into the β-cyclodextrin complexes. Norfloxacin, being amphoteric in nature, exhibits a higher solubility at pH below 4 and above 8. Addition of substances like ascorbic acid and citric acid in β-cyclodextrin complexes reduces the pH of the immediate microenvironment of the drug below pH 4. In the present work, β-cyclodextrin complexes of norfloxacin were prepared along with solubilizing additives such as citric acid and ascorbic acid in various proportion and the dissolution profile was performed in both HCl buffer, pH 1.2 and phosphate buffer, pH 7.4. The results have shown an enhanced dissolution rate in both media. DSC and IR spectral studies performed on the solid complexes have shown that there is no interaction of the drug with the additives and â-cyclodextrin. Disc diffusion studies have shown larger diameters of zone of inhibition indicating a greater diffusivity of the drug into the agar medium. © 2007 Bentham Science Publishers Ltd.
Dua, K, Sara, UVS, Sharma, VK, Agrawal, A, Ramana, MV & HImaja, M 2007, 'Breaking the skin barrier: Newer developments in transdermal drug delivery', Australian Journal of Pharmacy, vol. 88, no. 1051, pp. 74-76.
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Optimum therapeutic outcomes require not only proper drug selection but also effective drug delivery. The human skin is a readily accessible surface for drug delivery. Transdermal drug delivery - the delivery of drugs across the skin and into systemic circulation - is distinct from topical drug penetration, which targets local areas. Several new active transport technologies have been developed for the transdermal delivery. For example, microporation, medicated tattoos, needleless jet injectors, electrophoresis and phonophoresis are all being used to facilitate delivery of drugs across the epidermal barrier. However, only a few of these technologies are now commercially available. Various new technologies like microneedles in transdermal drug delivery also play a significant impact in the progress of this dermal technology.
Ramana, MV, Chaudhari, AD, Himaja, M, Satyanarayana, D & Dua, K 2007, 'An approach to minimize <i> Pseudomembranous</i> <i> colitis</i> caused by clindamycin through liposomal formulation', Indian Journal of Pharmaceutical Sciences, vol. 69, no. 3, pp. 390-390.
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Liposomal encapsulation is known to significantly improve the therapeutic index of a drug. In the present investigation liposomal formulations were chosen to transport clindamycin, which is considered as the most effective topical antibiotic for acne, into the skin layers. Liposomes with clindamycin phosphate were prepared using lipid film hydration method and the optimum ratio of the components was determined. The liposomes were characterized for their vesicle size, shape, encapsulation efficiency, % drug content and for in vitro skin permeation study. The results suggest that the average size of vesicles was found to be in range of 4.91-6.75 μm. Highest encapsulation efficiency (45.4%) and in vitro skin permeation (62%) was achieved with a formulation containing drug: lipid: cholesterol in the ratio of 1:1:1. Liposomal formulation of clindamycin phosphate with good skin permeation properties was incorporated into gel base and comparison of in vitro skin permeation was made with non liposomal marketed gel, both containing 1% clindamycin phosphate. Higher rate of drug release across the rat abdominal skin was found with liposomal gel (54%) than non-liposomal marketed gel (48.7%). Biological study revealed that by encapsulating clindamycin phosphate into liposomes the occurrence of Pseudomembranous colitis could be reduced significantly in comparison to plain clindamycin phosphate.
Williams, K 2007, 'Computer error', Pharmacy News, no. 26/APR., p. 23.
Williams, K 2007, 'Diuretic dilemma: Thiazide diuretic in gout: Clinical interventior', Pharmacy News, no. 19/JULY, p. 24.
Williams, K 2007, 'Double trouble', Pharmacy News, no. 7/JUNE, p. 28.
Williams, K 2007, 'Ease the sneeze', Pharmacy News, no. 30/AUG., p. 21.
Williams, K 2007, 'Facing up to sunsafe skin: Benzoyl peroxide and photosensitivity: A clinical intervention', Pharmacy News, no. 1/FEB., p. 22.
Williams, K 2007, 'Inappropriate orlistat - Women and weight loss: Clinical intervention', Pharmacy News, no. 15/MAR., p. 22.
Williams, K 2007, 'Patient has that sinking feeling', Pharmacy News, no. 11/OCT., p. 20.
Williams, K 2007, 'Risky business', Pharmacy News, no. 27/NOV., p. 22.
Williams, K 2007, 'Treating muscle sprains', Pharmacy News, no. SUPPL. SEPT., pp. 36-37.
