Publications

ANTMAN, KH, RYAN, L, ELIAS, A, SHERMAN, D & GRIER, HE 1989, 'RESPONSE TO IFOSFAMIDE AND MESNA - 124 PREVIOUSLY TREATED PATIENTS WITH METASTATIC OR UNRESECTABLE SARCOMA', JOURNAL OF CLINICAL ONCOLOGY, vol. 7, no. 1, pp. 126-131.
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Archer, LE & Ryan, LM 1989, 'Accounting for Misclassification in the Cause-of-Death Test for Carcinogenicity', Journal of the American Statistical Association, vol. 84, no. 407, pp. 787-787.
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ARCHER, LE & RYAN, LM 1989, 'ACCOUNTING FOR MISCLASSIFICATION IN THE CAUSE-OF-DEATH TEST FOR CARCINOGENICITY', JOURNAL OF THE AMERICAN STATISTICAL ASSOCIATION, vol. 84, no. 407, pp. 787-791.
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Archer, LE & Ryan, LM 1989, 'Accounting for misclassification in the cause-of-death test for carcinogenicity', Journal of the American Statistical Association, vol. 84, no. 407, pp. 787-791.
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The cause-of-death test (Peto 1974; Peto et al. 1980) provides a test for carcinogenicity without requiring extreme lethality assumptions. The approach has been criticized, however, because cause-of-death determinations require subjective decisions by pathologists and may be unreliable. Using a missing data formulation, we derive a simple, intuitive modification of the test that allows for misclassification of cause of death. The modified statistic is a function of the misclassification probabilities. A sensitivity analysis may be performed using a plausible range of values for these probabilities or, in certain situations, the misclassification probabilities can be estimated from the data. Both approaches are applied to data from the ED01 experiment. © 1989 Taylor & Francis Group, LLC.

ARCHER, LE & RYAN, LM 1989, 'ON THE ROLE OF CAUSE-OF-DEATH DATA IN THE ANALYSIS OF RODENT TUMORIGENICITY EXPERIMENTS', APPLIED STATISTICS-JOURNAL OF THE ROYAL STATISTICAL SOCIETY SERIES C, vol. 38, no. 1, pp. 81-93.
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CNAAN, A & RYAN, L 1989, 'SURVIVAL ANALYSIS IN NATURAL-HISTORY STUDIES OF DISEASE', STATISTICS IN MEDICINE, vol. 8, no. 10, pp. 1255-1268.
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Clinicians often wish to use data from clinical trials or hospital databases to study disease natural history. Of particular interest are estimated survival and prognostic factors. In this context, it may be appropriate to measure survival from diagnosis or some other time origin, possibly prior to study entry. We describe the application of methods for truncated survival data, and compare these with the standard product limit estimator and proportional hazards models in the measurement of survival from entry. Theoretical considerations suggest that analysis of survival from entry may under‐ or overestimate the survival distribution of interest, depending on the shape of the true underlying hazard. Analogous results hold for the coefficients from a proportional hazards model. We illustrate our findings with data from a multicenter clinical trial and a hospital database. Copyright © 1989 John Wiley & Sons, Ltd.

ELIAS, A, RYAN, L, SULKES, A, COLLINS, J, AISNER, J & ANTMAN, KH 1989, 'RESPONSE TO MESNA, DOXORUBICIN, IFOSFAMIDE, AND DACARBAZINE IN 108 PATIENTS WITH METASTATIC OR UNRESECTABLE SARCOMA AND NO PRIOR CHEMOTHERAPY', JOURNAL OF CLINICAL ONCOLOGY, vol. 7, no. 9, pp. 1208-1216.
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LANGE, N & RYAN, L 1989, 'ASSESSING NORMALITY IN RANDOM EFFECTS MODELS', ANNALS OF STATISTICS, vol. 17, no. 2, pp. 624-642.
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LEFKOPOULOU, M, MOORE, D & RYAN, L 1989, 'THE ANALYSIS OF MULTIPLE CORRELATED BINARY OUTCOMES - APPLICATION TO RODENT TERATOLOGY EXPERIMENTS', JOURNAL OF THE AMERICAN STATISTICAL ASSOCIATION, vol. 84, no. 407, pp. 810-815.
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Lefkopoulou, M, Moore, D & Ryan, L 1989, 'The analysis of multiple correlated binary outcomes: Application to rodent teratology experiments', Journal of the American Statistical Association, vol. 84, no. 407, pp. 810-815.
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In a developmental toxicity study, pregnant animals are exposed to the test substance and their offspring are assessed for defects. Often, multiple observations are made on each fetus, in which case the data are doubly nested. In this article we adapt the approach of Liang and Zeger (1986) and Zeger and Liang (1986) to yield an analysis, which appropriately allows for the correlation structure. © 1989 Taylor & Francis Group, LLC.

Lefkopoulou, M, Moore, D & Ryan, L 1989, 'The Analysis of Multiple Correlated Binary Outcomes: Application to Rodent Teratology Experiments', Journal of the American Statistical Association, vol. 84, no. 407, pp. 810-810.
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RYAN, LM 1989, 'CORRECTION', BIOMETRIKA, vol. 76, no. 2, pp. 407-407.

RYAN, LM & ORAV, JE 1989, '‘On the use of covariates for rodent bioassay and screening experiments’', Biometrika, vol. 76, no. 2, pp. 407-407.
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Equation (6) represents only an approximation to the maximum likelihood estimator, whose actual form satisfies. π(t)=∑i.yi∈Iwiexp(-ßbiai)ai/∑i:yi∈Iwiexp(-ßbiai)where. wiα[{1-π(t)}exp(-ßbi)+π(t)]-1Our reason for presenting (6) is its generalizability to the closed form, consistent prevalence estimator, (8). © 1989 Biometrika Trust.

SIEGEL, RD, RYAN, LM & ANTMAN, KH 1989, 'OSTEO-SARCOMA IN ADULTS - ONE INSTITUTIONS EXPERIENCE', CLINICAL ORTHOPAEDICS AND RELATED RESEARCH, vol. 240, no. 240, pp. 261-269.
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HERMAN, TS, JOCHELSON, MS, TEICHER, BA, SCOTT, PJ, HANSEN, J, CLARK, JR, PFEFFER, MR, GELWAN, LE, MOLNARGRIFFIN, BJ, FRASER, SM, SVENNSON, G, BORNSTEIN, BA, RYAN, L & COLEMAN, CN 1970, 'A PHASE-I-II TRIAL OF CISPLATIN, HYPERTHERMIA AND RADIATION IN PATIENTS WITH LOCALLY ADVANCED MALIGNANCIES', INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 30TH ANNUAL MEETING OF THE AMERICAN SOC FOR THERAPEUTIC RADIOLOGY AND ONCOLOGY, PERGAMON-ELSEVIER SCIENCE LTD, NEW ORLEANS, LA, pp. 1273-1279.
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