Anthony, MY, Goodall, SR, Papouli, M & Levene, MI 1992, 'Measurement of plasma volume in neonates', Archives of Disease in Childhood, vol. 67, no. 1 SPEC NO, pp. 36-40.
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There is no reliable and safe method for measuring plasma volume in ill newborn infants. We describe an adaptation of the dye dilution technique using indocyanine green as the plasma label, which can be used in the sickest and smallest of infants with the minimum of disturbance. To avoid the need to take large volumes of blood from the infant, samples were diluted 1:1 with distilled water and pooled adult sera was used to construct the dye dilution standard curves. Eighteen preterm and fullterm infants were studied on 30 occasions. The measured plasma volume ranged between 21.4 and 106 ml/kg. Paired measurements were performed within 30-90 minutes of each other in seven infants. In five infants estimations of plasma volume were made shortly before and 30 minutes after the infusion of a known quantity of plasma. In eight out of 12 infants who had two measurements made there was close agreement between the second measured volume and the first measured volume, taking into account how much plasma had been given to or taken from the infant between the two measurements. The error ranged from 0.2 to 5.2 ml and the plasma recovery error ranged from -2.9% to +4.7%. In the remaining four infants the errors ranged from 2.1 to 9.5 ml and -14.2% to +8.8%. Errors in the measurement of plasma volume may arise as the result of sampling too early before full mixing of the dye has occurred, and there is a potential error in the measurement due to the distribution of albumin in the extracellular space in sick infants resulting in an overestimation of the plasma volume. Proposals for reducing sources of errors are discussed.
The Oregon Plan is an ambitious attempt to address the widespread problem in the United States of a growing number of individuals who are without private health insurance and are not eligible for federal assistance programs. Its aim is to provide univers
Hall, JP, Gerard, K, Salkeld, G & Richardson, J 1992, 'A Cost Utility Analysis Of Mammography Screening In Australia', Social Science & Medicine, vol. 34, no. 9, pp. 993-1004.
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Cost utility analysis is the preferred method of analysis when quality of life instead is an important outcome of the project being appraised. However, there are several methodological issues to be resolved in implementing cost utility analysis, includin
Upper bounds for the average efficiency factor of single block and resolvable row-column designs, based on the first two moments of the canonical efficiency factors, are obtained. In 245 out of the 379 cases considered these bounds are tighter than a bou
Mooney, G, Hall, JP, Donaldson, C & Gerard, K 1992, 'Reweighing Heat - Response to Culyer, van Doorslaer and Wagstaff', Journal Of Health Economics, vol. 11, no. 2, pp. 199-205.
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We examine the structure of, and give methods of construction for, strongly equineighboured designs. We show that when k = 4 and s = 1 the necessary conditions for the existence of these designs are sufficient. When k = 6 and s = 1 we show that there are
Cameron, S, Kenny, PM, Scott, A & King, MT CHERE 1992, Evaluation of obstetric early discharge - reasons for non-participation, CHERE Discussion Paper No 11, Sydney.
Cleland, S, Cameron, S, Kenny, PM, King, MT, Scott, A & Shiell, A CHERE 1992, Evaluation of obstetric early discharge - overview, CHERE Discussion Paper No 9, Sydney.
Farnworth, M & Kenny, PM CHERE 1992, An economic evaluation of a fractured hip management program., CHERE Discussion Paper No 8, Sydney.
Haas, MR CHERE 1992, A cost utility analysis of physiotherapy, CHERE Discussion Paper No 6, Sydney.
Kenny, PM, Cameron, S, King, MT, Scott, A & Shiell, A CHERE 1992, Evaluation of obstetric early discharge - client satisfaction, CHERE Discussion Paper No 10, Sydney.
Scott, A, Cameron, S, Kenny, PM, King, MT & Shiell, A CHERE 1992, Evaluation of obstetric early discharge - economic evaluation, CHERE Discussion Paper No 12, Sydney.
Shiell, A, Haas, MR, King, MT, Jan, S & Seymour, J CHERE 1992, Optimal size and throughput of tertiary services: A Case Study in Renal Transplant and Cardiac Surgery in NSW, CHERE Discussion Paper No 5, Sydney.