Publications

Louviere, JJ & Street, D 2000, 'Stated-preference Methods' in Hensher, DA & Button, KJ (eds), Handbook of Transport Modelling, Pergamon Press, Amsterdam, Netherlands, pp. 131-143.

Boyle, JR, Goodall, S, Thompson, JP, Bell, PRF & Thompson, MM 2000, 'Endovascular AAA Repair Attenuates the Inflammatory and Renal Responses Associated With Conventional Surgery', Journal of Endovascular Therapy, vol. 7, no. 5, pp. 359-371.
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Crowther, M, Goodall, S, Jones, JL, Bell, PRF & Thompson, MM 2000, 'Increased matrix metalloproteinase 2 expression in vascular smooth muscle cells cultured from abdominal aortic aneurysms', Journal of Vascular Surgery, vol. 32, no. 3, pp. 575-583.
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De Abreu Lourenco, R 2000, 'Stated Preference Discrete Choice Modelling', CHERE Health Economics Review, no. 15.

Hall, J 2000, 'Health for all: the impossible dream?', LANCET, vol. 356, pp. S32-S32.
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Hall, JP 2000, 'Health For All The Impossible Dream?', Lancet, vol. 356, no. 0, pp. 0-0.
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Kenny, P, King, LM, Shiell, A, Seymour, J, Hall, J, Langlands, A & Boyages, J 2000, 'Early stage breast cancer: costs and quality of life one year after treatment by mastectomy or conservative surgery and radiation therapy', BREAST, vol. 9, no. 1, pp. 37-44.
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This paper reports a descriptive study of the costs and quality of life (QoL) outcome of treatments for early stage breast cancer in a cohort of Australian women, one year after initial surgical treatment. Mastectomy without breast reconstruction is comp

Kenny, P, King, MT, Sheill, A, Seymour, J, Hall, J, Langlands, A & Boyages, J 2000, 'DIARY', The Breast, vol. 9, no. 5, pp. 299-299.
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Kenny, P, King, MT, Sheill, A, Seymour, J, Hall, J, Langlands, A & Boyages, J 2000, 'Early stage breast cancer: costs and quality of life one year after treatment by mastectomy or conservative surgery and radiation therapy (vol 9, pg 37, 2000)', BREAST, vol. 9, no. 5, pp. 299-299.

King, MT, Hall, J, Caleo, S, Gurney, HP & Harnett, PR 2000, 'Home or hospital? An evaluation of the costs, preferences, and outcomes of domiciliary chemotherapy', INTERNATIONAL JOURNAL OF HEALTH SERVICES, vol. 30, no. 3, pp. 557-579.
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The study compares the costs and outcomes of domiciliary and hospital-based chemotherapy, using a prospective randomized cross-over design. Eighty-seven eligible patients were recruited from oncology services at two metropolitan hospitals in Sydney, Aust

King, MT, Kenny, P, Shiell, A, Hall, J & Boyages, J 2000, 'Quality of life three months and one year after first treatment for early stage breast cancer: Influence of treatment and patient characteristics', QUALITY OF LIFE RESEARCH, vol. 9, no. 7, pp. 789-800.
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This paper reports the quality of life (QoL) of a large cohort of Australian women three and twelve months after surgery for early stage breast cancer (ESBC), and shows that the impact of disease and treatment on QoL differed by age, education and marita

Loftus, IM, Naylor, AR, Goodall, S, Crowther, M, Jones, L, Bell, PR & Thompson, MM 2000, 'Increased matrix metalloproteinase-9 activity in unstable carotid plaques. A potential role in acute plaque disruption.', Stroke, vol. 31, no. 1, pp. 40-47.
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BACKGROUND AND PURPOSE: Acute disruption of atherosclerotic plaques precedes the onset of clinical syndromes, and studies have implicated a role for matrix metalloproteinases (MMPs) in this process. The aim of this study was to establish the character, level, and expression of MMPs in carotid plaques and to correlate this with clinical status, cerebral embolization, and histology. METHODS: Plaques were obtained from 75 consecutive patients undergoing carotid endarterectomy and divided into 4 groups according to symptomatology (group 1, asymptomatic; group 2, symptomatic >6 months before surgery; group 3, symptomatic within 1 to 6 months; group 4, symptomatic within 1 month). All patients underwent preoperative and intraoperative transcranial Doppler monitoring. Plaques were subjected to histological examination and quantification of MMPs by zymography and ELISA. RESULTS: The level of MMP-9 was significantly higher in group 4 (median 125.7 ng/mL for group 4, median <32 ng/mL for all other groups; P=0.003), with no difference in the levels of MMPs 1, 2, or 3. Furthermore, the MMP-9 concentration was significantly higher in plaques undergoing spontaneous embolization (P=0.019) and those with histological evidence of plaque instability (P<0.03). In situ hybridization demonstrated increased MMP-9 expression in highly symptomatic plaques in areas of intense inflammatory infiltrate. CONCLUSIONS: The concentration, production, and expression of MMP-9 is significantly higher in unstable carotid plaques. If this proves to be a causal relationship, MMP-9 may be a strong candidate for pharmacotherapy aimed at stabilizing plaques and preventing stroke.

Loftus, IM, Naylor, AR, Goodall, S, Crowther, M, Jones, L, Bell, PRF & Thompson, MM 2000, 'Increased Matrix Metalloproteinase-9 Activity in Unstable Carotid Plaques', Stroke, vol. 31, no. 1, pp. 40-47.
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Background and Purpose —Acute disruption of atherosclerotic plaques precedes the onset of clinical syndromes, and studies have implicated a role for matrix metalloproteinases (MMPs) in this process. The aim of this study was to establish the character, level, and expression of MMPs in carotid plaques and to correlate this with clinical status, cerebral embolization, and histology. Methods —Plaques were obtained from 75 consecutive patients undergoing carotid endarterectomy and divided into 4 groups according to symptomatology (group 1, asymptomatic; group 2, symptomatic >6 months before surgery; group 3, symptomatic within 1 to 6 months; group 4, symptomatic within 1 month). All patients underwent preoperative and intraoperative transcranial Doppler monitoring. Plaques were subjected to histological examination and quantification of MMPs by zymography and ELISA. Results —The level of MMP-9 was significantly higher in group 4 (median 125.7 ng/mL for group 4, median <32 ng/mL for all other groups; P =0.003), with no difference in the levels of MMPs 1, 2, or 3. Furthermore, the MMP-9 concentration was significantly higher in plaques undergoing spontaneous embolization ( P =0.019) and those with histological evidence of plaque instability ( P <0.03). In situ hybridization demonstrated increased MMP-9 expression in highly symptomatic plaques in areas of intense inflammatory infiltrate. Conclusions —The concentration, production, and expression of MMP-9 is significantly higher...

Lowin, A, Slater, J, Hall, J & Alperstein, G 2000, 'Cost effectiveness analysis of school based mantoux screening for TB infection', AUSTRALIAN AND NEW ZEALAND JOURNAL OF PUBLIC HEALTH, vol. 24, no. 3, pp. 247-253.
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OBJECTIVE To assess the cost-effectiveness of adding school based Mantoux screening programs to the New South Wales current TB prevention strategy. METHOD A decision analysis model compared the costs and consequences of screening strategies against the c

Viney, R & Haas, M 2000, 'A practical approach to planning health services: using PBMA', Australian Health Review, vol. 23, no. 3, pp. 10-10.
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Planning health services is a difficult and often complex task. There are many approaches to planning, including theuse of tools such as needs assessment, goals and targets, as well as economics-based tools such as cost of illness oreconomic evaluation. It is not always clear which planning tool is the most appropriate. In this paper we comparean economics approach to planning using program budgeting and marginal analysis (PBMA) with other approaches.We provide an overview of the methods of PBMA, report on experience with its use, and draw conclusions about itslikely usefulness to health services planners.

Viney, R, Fulham, MJ, McCaughan, BC, Boyer, MJ, King, M, Kenny, P, Hass, M, Lowin, A, McLean, J, Cvetanovski, V & Pollocino, C 2000, 'Whole body FDG-PET in apparently-resectable NSCLC: Outline and design of the first randomised controlled trial of FDG-PET in NSCLC', Lung Cancer, vol. 29, no. 1, pp. 253-253.
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Viney, RC, Fulham, MJ, McCaughan, BC, Boyer, MJ & Hall, JP 2000, 'Evaluation of the role of positron emission tomography in oncology', MEDICAL JOURNAL OF AUSTRALIA, vol. 172, no. 9, pp. 459-+.
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Wang, IY, Fraser, IS, Barsamian, SP, Manconi, F, Street, DJ, Cornillie, FJ & Russell, P 2000, 'Endometrial lysosomal enzyme activity in ovulatory dysfunctional uterine bleeding, IUCD users and post-partum women', Molecular Human Reproduction, vol. 6, no. 3, pp. 258-263.
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The aim of this study was to evaluate the role of lysosomal enzymes in excessively heavy menstruation by comparing women with menorrhagia due to dysfunctional bleeding or intrauterine contraceptive device (IUCD) use with those with normal menstrual periods or with amenorrhoea associated with breastfeeding. This was a prospective cohort investigation of the activity of four endometrial lysosomal enzymes in three contrasting groups: (i) women with ovulatory dysfunctional uterine bleeding and users of intrauterine contraceptive devices; (ii) breastfeeding post-partum women in whom there are long periods of amenorrhoea, particularly in the early months post-partum; and (iii) normal cycling women. It was found that the total activity of lysosomal enzymes, particularly acid phosphatase and N-acetyl-β-D- glucosaminidase, was markedly elevated (P<0.001) in IUCD-exposed endometrium, and endometrium from women with dysfunctional uterine bleeding when compared with endometrium from women with a history of entirely normal menstrual periods or that in post-partum breastfeeding women. The activity of α-L- fucosidase was moderately elevated in IUCD users (P < 0.05) and ovulatory dysfunctional uterine bleeding (P < 0.05), whereas αD-mannosidase activity was elevated in ovulatory dysfunctional uterine bleeding (P < 0.05), but decreased in IUCD users (P < 0.01). No significant differences were observed in the lysosomal enzyme activities of breastfeeding post-partum women and normal cycling women. These results show that total endometrial tissue activity of four lysosomal enzymes was substantially increased throughout the cycle in most circumstances in women with two different causes for increased menstrual bleeding. This suggests a contributory role to the increased bleeding.

Haas, M, Viney, R & Shanahan, M CHERE 2000, Service impact analysis of telehealth in NSW, CHERE Project Report No 12, Sydney.

Kenny, P, King, MT, Shiell, A, Seymour, J, Boyages, J & Hall, JP CHERE 2000, Quality of life three months and one year anter treatment for early stage breast cnacer, CHERE Discussion Paper No 42, Sydney.

Viney, R, Lourenco, RDA, Kitcher, D & Gerard, K CHERE 2000, NSW breast and cervical screening program review, CHERE Project Report No 14, Sydney.