Coombe, RG & George, AM 1981, 'New plasmid-mediated aminoglycoside adenylyltransferase of broad substrate range that adenylylates amikacin', Antimicrobial Agents and Chemotherapy, vol. 20, no. 1, pp. 75-80.
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The same aminoglycoside 2'-adenylyltransferase was isolated from four gram-negative species which were among a random group of gentamicin-resistant isolates from the same hospital. The enzyme was partially purified from a crude extract which also contained a second modifying enzyme identified as APH(3')-I. The substrate range of the new aminoglycoside 2'-adenylyltransferase included the newer aminoglycosides sisomicin and amikacin, but showed much-reduced activity against gentamicins C2 and Cla. The pH optimum was 7.8 to 8.0 for every substrate, and the molecular weight of the enzyme molecule was estimated at approximately 29,000. Genetic experiments clearly established that both enzymes were expressed by a conjugative plasmid.
Hoang, DB & Goodwin, GC 1981, 'Lower bound on one shot error probability', Electronics Letters, vol. 17, no. 7, pp. 261-261.
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A number of upper and lower bounds have been described in the literature for the error performance of digital communication channels for the case of white output noise.1,2 In this letter a lower bound on the probability of error for one shot communication over a general linear channel with coloured noise is derived. © 1981, The Institution of Electrical Engineers. All rights reserved.
PEREZ, DJ, TAYLOR, IW, MILTHORPE, BK, MCGOVERN, VJ & TATTERSALL, MHN 1981, 'IDENTIFICATION AND QUANTITATION OF TUMOR-CELLS IN CELL-SUSPENSIONS - A COMPARISON OF CYTOLOGY AND FLOW-CYTOMETRY', BRITISH JOURNAL OF CANCER, vol. 43, no. 4, pp. 526-531.
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FLOW-CYTOMETRIC MEASUREMENTS of cell DNA content or narrow-angle light scatter (NLS) can provide a basis for discriminating neoplastic from non-neoplastic cells by identifying differences in DNA content and cell size. Flow-cytometric analyses of many human neoplasms have been previously reported (Barlogie et at., 977, 1978) showing aneuploidy in 80-90% of non-lymphoid solid tumours and 40- 60% of non-Hodgkin's lymphomas. In leukaemias, and multiple myelomas with and aneuploid tumour clone, the percentage of neoplastic cells in marrow or blood determined by DNA content correlates well with quantitation based on histologic smears (Barlogie et al., 1977; Latreille et al., 1980; Andreeff et al., 1980) but such a comparison has not been made on cell suspensions from solid tumours.
