Anast, M, Jamting, Å, Bell, JM & Ben-Nissan, B 1994, 'Surface morphology examination of sol-gel deposited TiO2 films', Thin Solid Films, vol. 253, no. 1-2, pp. 303-307.
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Thin films of TiO2 were deposited by spin-coating onto both single-point diamond machined (SPDM) disks and mechanically polished disks of aluminum. A titanium alkoxide sol-gel precursor was used and films were heat treated after deposition to remove organic components. This work is being undertaken to analyse the nature of the surface morphology produced by spin-coating, and to examine how the surface morphology can be modified. Detailed analysis of the surface morphology of the films was carried out using atomic force microscopy (AFM). The uncoated surfaces of the SPDM samples show cutting marks characteristics of the single-point diamond machining process, while these have largely disappeared on the coated surfaces. The coatings show some regions where flow lines are apparent, probably arising from the spinning process, but are otherwise quite featureless, indicating good surface coverage in the spinning process. Line and area scans of the coated surfaces were used to measure the surface roughness. An analysis of measured roughness as a function of the area of measurement indicates that the measured roughness increases with the area of the measurement. This applies to both line and area scans. Roughness measurements over macroscopic lenghts were also carried out with a stylus profilometer and these results are compared with the AFM measurements. Line scans of the surface profile of the materials show long wavelength surface features in some of the samples which are attributed to the diamond machining process. © 1994.
Ardekani, BA, Braun, M, Kanno, I & Hutton, BF 1994, 'Automatic Detection of Intradural Spaces in MR Images', Journal of Computer Assisted Tomography, vol. 18, no. 6, pp. 963-969.
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Objective: An algorithm is presented for the automatic detection of intradural spaces in MR images of the human head. The primary motivation behind the present work has been to serve as a preprocessing step in automatic segmentation of brain tissue and CSF. A second objective was to use the algorithm in a fully automatic PET-MR registration algorithm. Materials and Methods: The method is primarily designed for, and requires, dual echo (Tl- and T2-weighted) MR images with transaxial orientations. The algorithm consists of three main stages. First, the head contour is detected using a series of low-level image-processing techniques. In the second stage, the pixels inside the head contour are clustered into a number of classes using the K-means algorithm. Finally, the extradural connected components are eliminated based on a number of heuristics. Results: Test results are presented for 10 MR image sets consisting of 197 slices. As a quantitative measure of accuracy, manual segmentations were performed by radiologists on a number of slices and compared with the results obtained automatically. Conclusion: Visual inspection and quantitative validation of the results indicate that the algorithm accurately detects the intradural spaces in MR images. This is an important step in fully automatic segmentation and registration of MR images. © 1994 Raven Press, Ltd., New York.
Fulton, RR, Hutton, BF, Braun, M, Ardekani, B & Larkin, R 1994, 'Use of 3D reconstruction to correct for patient motion in SPECT', Physics in Medicine and Biology, vol. 39, no. 3, pp. 563-574.
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Patient motion occurring during data acquisition in single photon emission computed tomography (SPECT) can cause serious reconstruction artefacts. The authors have developed a new approach to correct for head motion in brain SPECT. Prior to motion, projections are assigned to conventional projections. When head motion occurs, it is measured by a motion monitoring system, and subsequent projection data are mapped to 'virtual' projections. The appropriate position of each virtual projection is determined by applying the converse of the patient's accumulated motion to the actual camera projection. Conventional and virtual projections, taken together, form a consistent set that can be reconstructed using a three-dimensional (3D) algorithm. The technique has been tested on a range of simulated rotational movements, both within and out of the transaxial plane. For all simulated movements, the motion corrected images exhibited better agreement with a motion free reconstruction than did the uncorrected images. This technique may help to overcome one of the major remaining limitations on image quality and quantitative accuracy in SPECT.
GARCIA, JNP, MILTHORPE, BK, RUSSELL, D & JOHNSON, KA 1994, 'BIOMECHANICAL STUDY OF CANINE SPINAL FRACTURE FIXATION USING PINS OR BONE SCREWS WITH POLYMETHYLMETHACRYLATE', VETERINARY SURGERY, vol. 23, no. 5, pp. 322-329.
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George, SR, Zastawny, RL, Brionesurbina, R, Cheng, R, Nguyen, T, Heiber, M, Kouvelas, A, Chan, AS & Odowd, BF 1994, 'Distinct Distributions of Mu, Delta and Kappa Opioid Receptor mRNA in Rat Brain', Biochemical and Biophysical Research Communications, vol. 205, no. 2, pp. 1438-1444.
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We present a comprehensive comparison of the anatomical distributions of the cloned mu, delta and kappa opioid receptor mRNA in rat brain. Northern blot analysis revealed that mRNA species encoding the three receptors differed in size and were differentially localized in brain regions. In peripheral tissues analyzed, the 3 mRNA species were detected only in the spinal cord. The distributions of mu, delta and kappa receptor mRNA in rat brain were examined by in situ hybridization histochemistry using gene-specific probes. Mu receptor mRNA was predominately localized to thalamic, brainstem and reticular core nuclei and was highest in the habenular and thalamic nuclei. In contrast, kappa receptor mRNA was expressed in hippocampus including dentate gyrus, hypothalamic and some thalamic nuclei and also present in cortex, caudate putamen, olfactory tubercle and nucleus accumbens. Delta receptor mRNA was prominent in cerebral cortex, olfactory tubercle, hippocampus, caudate putamen and nucleus accumbens. These results show that the mRNA distribution for each opioid receptor subtype in brain is unique and correlate well with the known distribution of the corresponding opioid receptor binding sites. © 1994 Academic Press. Inc.
Hoffman, D, Nguyen, T, O'Sullivan, A, Baxter, R & Ho, KY 1994, 'ITT and IGF-I in the diagnosis of growth hormone deficiency in adults', The Lancet, vol. 344, no. 8922, pp. 613-614.
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Johnson, AG 1994, 'Do Nonsteroidal Anti-inflammatory Drugs Affect Blood Pressure? A Meta-Analysis', Annals of Internal Medicine, vol. 121, no. 4, pp. 289-289.
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JONES, AS, MILTHORPE, BK & HOWLETT, CR 1994, 'MEASUREMENT OF MICROTOMY INDUCED SECTION DISTORTION AND ITS CORRECTION FOR 3-DIMENSIONAL HISTOLOGICAL RECONSTRUCTIONS', CYTOMETRY, vol. 15, no. 2, pp. 95-105.
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The presence of microtomy induced distortion in paraffin sections is a significant hindrance to the accurate alignment of sections for three-dimensional reconstructive techniques. Measurement of section distortion in various rat tissues demonstrated distortions to be present in all sections, with over 85% of such distortions being manifest as expansions when compared to the original distances between a series of eight drilled fiducial marks. Mean percentage dimensional changes in the direction of the cutting stroke and at right angles to this direction were -0.5 ± 1.5% and 3.7 ± 1.2% for liver, 7.6 ± 2.4% and 9.1 ± 1.2% for kidney, 6.6 ± 2.3% and 10.5 ± 1.4% for lung, and 20.3 ± 6.6% and 8.9 ± 5.9% for skeletal muscle. Individual sections invariably displayed measurable distortions, with only skeletal muscle showing any consistent pattern, in the form of barrel distortion at right angles to the cutting stroke. In addition a method of distortion correction and simultaneous image alignment is presented as a means of section alignment with full distortion correction capability. This method uses a quadratic polynomial transform in a non-linear unwarping algorithm, to correct for the rotational and translational misalignment as well as for microtomy and camera aspect ratio distortions. Application of this method to a sequence of 46 serial sections demonstrated an alignment accuracy to within 2.6 ± 0.8 pixels
Jones, G, Nguyen, T, Sambrook, P, Kelly, PJ & Eisman, JA 1994, 'Progressive loss of bone in the femoral neck in elderly people: longitudinal findings from the Dubbo osteoporosis epidemiology study', BMJ, vol. 309, no. 6956, pp. 691-695.
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Jones, G, Nguyen, T, Sambrook, PN, Kelly, PJ, Gilbert, C & Eisman, JA 1994, 'Symptomatic fracture incidence in elderly men and women: The Dubbo osteoporosis epidemiology study (DOES)', Osteoporosis International, vol. 4, no. 5, pp. 277-282.
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LIU, YS & HOANG, DB 1994, 'OSI RPC MODEL AND PROTOCOL', COMPUTER COMMUNICATIONS, vol. 17, no. 1, pp. 53-66.
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Remote procedure call (RPC) provides a useful paradigm for developing distributed applications. The growing use of RPC in developing distributed applications has resulted in international efforts to standardize RPC mechanisms to ensure future interoperab
Lord, SR, Webster, IW, Sambrook, PN, Gilbert, C, Kelly, PJ, Nguyen, T & Eisman, JA 1994, 'Postural stability, falls and fractures in the elderly: results from the Dubbo Osteoporosis Epidemiology Study', Medical Journal of Australia, vol. 160, no. 11, pp. 684-691.
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Marchese, A, Docherty, JM, Nguyen, T, Heiber, M, Cheng, R, Heng, HHQ, Tsui, L-C, Shi, X, George, SR & O'Dowd, BF 1994, 'Cloning of Human Genes Encoding Novel G Protein-Coupled Receptors', Genomics, vol. 23, no. 3, pp. 609-618.
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We report the isolation and characterization of several novel human genes encoding G protein-coupled receptors. Each of the receptors contained the familiar seven transmembrane topography and most closely resembled peptide binding receptors. Gene GPR1 encoded a receptor protein that is intronless in the coding region and that shared identity (43% in the transmembrane regions) with the opioid receptors. Northern blot analysis revealed that GPR1 transcripts were expressed in the human hippocampus, and the gene was localized to chromosome 15q21.6. Gene GPR2 encoded a protein that most closely resembled an interleukin-8 receptor (51% in the transmembrane regions), and this gene, not expressed in the six brain regions examined, was localized to chromosome 17q21.1-q21.3. A third gene, GPR3, showed identity (56% in the transmembrane regions) with a previously characterized cDNA clone from rat and was localized to chromosome 1p35-p36.1. © 1994 Academic Press, Inc.
Marsh, DJ, Robinson, BG, Andrew, S, Richardson, A-L, Pojer, R, Schnitzler, M, Mulligan, LM & Hyland, VJ 1994, 'A Rapid Screening Method for the Detection of Mutations in the RET Proto-oncogene in Multiple Endocrine Neoplasia Type 2A and Familial Medullary Thyroid Carcinoma Families', Genomics, vol. 23, no. 2, pp. 477-479.
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McMurry, LM, George, AM & Levy, SB 1994, 'Active efflux of chloramphenicol in susceptible Escherichia coli strains and in multiple-antibiotic-resistant (Mar) mutants', Antimicrobial Agents and Chemotherapy, vol. 38, no. 3, pp. 542-546.
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The multiple-antibiotic resistance (mar) locus (min 34) regulates a resistance to chloramphenicol in Escherichia coli that does not involve acetyltransferase. Transport studies showed that wild-type cells had an apparent endogenous active efflux of chloramphenicol which depended on the proton motive force. This efflux was not altered by a 39-kb chromosomal deletion which included the mar locus. Nevertheless, mutations at the mar locus led to a stronger net chloramphenicol efflux. Therefore, a gene encoding the putative efflux system cannot be at the mar locus but may be positively influenced by that locus.
Melrose, J, Rodgers, K & Ghosh, P 1994, 'The Preparation and Use of Biotinylated Trypsin in Western Blotting for the Detection of Trypsin Inhibitory Proteins', Analytical Biochemistry, vol. 222, no. 1, pp. 34-43.
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Methods were developed for the preparation of biotinylated trypsin of high specific activity. This was used as a probe for the detection of serine proteinase inhibitory proteins which had been separated by sodium dodecyl sulfate-polyacrylamide gradient s
MILTHORPE, BK 1994, 'XENOGRAFTS FOR TENDON AND LIGAMENT REPAIR', BIOMATERIALS, vol. 15, no. 10, pp. 745-752.
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Morrison, NA, Qi, JC, Tokita, A, Kelly, PJ, Crofts, L, Nguyen, TV, Sambrook, PN & Eisman, JA 1994, 'Prediction of Bone Density from Vitamin D Receptor Alleles', The Endocrinologist, vol. 4, no. 4, pp. 320-320.
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Morrison, NA, Qi, JC, Tokita, A, Kelly, PJ, Crofts, L, Nguyen, TV, Sambrook, PN & Eisman, JA 1994, 'Prediction of bone density from vitamin D receptor alleles', Nature, vol. 367, no. 6460, pp. 284-287.
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Nassif, NT, Glenn, WK & Mackinlay, AG 1994, 'The organization of the ?-globin gene of the bivalve mollusc Anadara trapezia and its evolutionary relationship to other invertebrate and vertebrate globin genes', Journal of Molecular Evolution, vol. 39, no. 1, pp. 47-55.
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Nguyen, T, Jones, G, Sambrook, P, Kelly, P, Lord, S, Freund, J & Eisman, J 1994, 'Authors' reply', BMJ, vol. 308, no. 6923, pp. 274-275.
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Nguyen, TV, Kelly, PJ, Sambrook, PN, Gilbert, C, Pocock, NA & Eisman, JA 1994, 'Lifestyle factors and bone density in the elderly: Implications for osteoporosis prevention', Journal of Bone and Mineral Research, vol. 9, no. 9, pp. 1339-1346.
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Abstract Epidemiologic evidence suggests that lifestyle factors, such as exercise, calcium intake, and tobacco consumption, have effects on bone density. However, the influence of these factors in the elderly has not been well documented. To examine the effects of lifestyle factors in the elderly, we measured bone density (BMD) at the lumbar spine and proximal femur in 709 elderly men and 1080 women participating in the Dubbo Osteoporosis Epidemiology study (DOES), a community-based, longitudinal, epidemiologic study of osteoporosis in men and women over the age of 60. BMD was significantly higher in men than in women (20% at all sites). There was an age-related decline in BMD at the femoral neck in both sexes and at the lumbar spine in women. Between the ages of 60 and 80, the decrease in BMD at the femoral neck among women was 18.9%, which is almost twice the decrease in BMD among men (10.1%). Tobacco consumption was associated with a reduction in BMD at both sites in both sexes (5-8%), and this effect was independent of calcium intake or body weight. Exsmokers had BMD intermediate between that of current smokers and never smokers, suggesting the influence of tobacco was partially reversible. Quadriceps strength predicted bone density at the proximal femur in elderly men but not in women. Analyzing BMD (adjusted for age and weight) in tertiles of muscle strength and calcium intake revealed an interaction between calcium intake and muscle strength on bone density; BMD at the femoral neck among those with higher quadriceps strength and calcium intake was approximately 5% higher (P < 0.05) than in those with low quadriceps strength and calcium intake in both men and women. These data indicate that lifestyle factors, such as tobacco consumption, calcium intake, and physical activity, may influence bone density in the elderly. Modification of these lifestyle factors may influence osteoporotic fracture ...
NORDON, RE, MILTHORPE, BK, SCHINDHELM, K & SLOWIACZEK, PR 1994, 'AN EXPERIMENTAL-MODEL OF AFFINITY CELL-SEPARATION', CYTOMETRY, vol. 16, no. 1, pp. 25-33.
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Cell affinity separations are based on the selective attachment of cell pheno-type using antibody or lectins specific for cell surface markers. The major physico-chemical factors which influence ligand-mediated cell adhesion dynamics and the efficiency of cell affinity separation have been examined. Uniform cell detachment forces were generated with a parallel-plate flow cell (plate separation 100 m, surface area 3 cm2). Hydrodynamic shear stress was used to measure cell adhesion strength and to separate cells on the basis of surface affinity. Human cell lines grown in tissue culture were separated on a flat derivatised glass immunoadsorbent which formed the floor of the flow chamber. Flow-cell residence time, detachment shear stress, temperature, and ligand density were shown to influence cell attachment probability. An understanding of the physical basis of ligand-mediated cell adhesion provided a rationale for optimisation of affinity cell separation. At room temperature attachment of positive cells was rapid (<2 min) and adhesion strength was directly related to immunoadsorbent ligand density. Purity and recovery of enriched fractions were dependent on the separation shear stress and could be optimised using this parameter. Enrichment factors were greater than 100-fold, with at least 90% of positive cells recovered in enriched fractions. Enrichment purity and yields did not decline at higher loading densities (105 cells/cm2). Selective immunoadsorbent surface chemistry is a prerequisite for efficient affinity cell separation. Purity and recovery may be optimised by fractionating enriched and depleted cell populations with uniform fluid shear stress.
Parfitt, AM, Nguyen, TV, Kelly, PJ, Morrison, NA, Sambrook, PN, Eisman, JA, Melhus, H, Kindmark, A & Ljunghall, S 1994, 'Vitamin D receptor genotypes in osteoporosis', The Lancet, vol. 344, no. 8936, pp. 1580-1581.
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Sambrook, PN, Kelly, PJ, Fontana, D, Nguyen, T, Keogh, A, Macdonald, P, Spratt, P, Freund, J & Eisman, JA 1994, 'Mechanisms of rapid bone loss following cardiac transplantation', Osteoporosis International, vol. 4, no. 5, pp. 273-276.
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Tokita, A 1994, 'Genetic influences on type I collagen synthesis and degradation: further evidence for genetic regulation of bone turnover', Journal of Clinical Endocrinology & Metabolism, vol. 78, no. 6, pp. 1461-1466.
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Tokita, A, Kelly, PJ, Nguyen, TV, Qi, JC, Morrison, NA, Risteli, L, Risteli, J, Sambrook, PN & Eisman, JA 1994, 'Genetic influences on type I collagen synthesis and degradation: further evidence for genetic regulation of bone turnover.', The Journal of Clinical Endocrinology & Metabolism, vol. 78, no. 6, pp. 1461-1466.
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Circulating osteocalcin, a marker of bone formation, is under strong genetic influence, and this effect is related to the genetic influence on bone density. To examine genetic influences on bone turnover further, other markers of bone formation (serum carboxyterminal propeptide of type I procollagen, PICP), bone resorption (serum pyridinoline cross-linked carboxyterminal telopeptide of type I collagen, ICTP), and nonosseous connective tissue synthesis (serum aminoterminal propeptide of type III procollagen, PIIINP) were studied in 82 female twin pairs: 42 monozygotic (MZ) and 40 dizygotic (DZ) twin pairs (mean age, MZ; 48.4 yr; DZ; 45.6 yr). The intraclass correlation coefficients of MZ twin pairs, rMZ, for serum PICP (0.78) and serum ICTP (0.68) were significantly greater than the corresponding rDZ (0.31 and 0.36, respectively), but a genetic effect on serum PIIINP was not demonstrable. Within DZ twin pair differences in serum PICP predicted differences in lumbar spine bone density (r = -0.37); higher serum PICP levels indicating the twin with the lower lumbar spine bone density. Also within pair differences in serum ICTP and PICP predicted differences in bone density at the lumbar spine independent of serum osteocalcin. These data indicate that both synthesis and degradation of type I collagen are genetically determined and that this phenomenon is related to the genetic regulation of bone density. © 1994 by The Endocrine Society.
Walker, JS, Nguyen, TV & Day, RO 1994, 'Clinical response to non‐steroidal anti‐inflammatory drugs in urate‐ crystal induced inflammation: a simultaneous study of intersubject and intrasubject variability.', British Journal of Clinical Pharmacology, vol. 38, no. 4, pp. 341-347.
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1. It is well known that an individual subject often responds preferentially to a particular nonsteroidal anti‐inflammatory drug (NSAID) and clinical response to these drugs is characterised by considerable variability between individuals. Variability in response has often been attributed to the episodic nature of musculoskeletal disease. Few studies have studied intrasubject variability in response to these drugs using a multiple crossover design. A major difficulty has been the lack of objective, validated measures of inflammation sensitive to NSAIDs. The primary aim of the present study was to test the utility of urate‐crystal induced inflammation as a tool to predict NSAID response in humans. 2. An inflammatory reaction was established in twenty‐five healthy subjects with intradermal injection of urate crystals on four separate occasions separated by 1 week. Each subject was randomly assigned to receive either ibuprofen on two of these occasions (800 mg four times over 36 h) or matched placebo on the other two occasions using a double‐blind, cross‐over design. Decrease in the area under the wheal size‐time curve was used to indicate anti‐ inflammatory response. 3. Peak inflammatory response was observed at about 32 h and had dissipated by 56 h post‐urate injection. The logarithmic mean wheal area was significantly lower after ibuprofen (mean +/‐ s.e. mean; 6.74 +/‐ 0.09) compared with placebo (6.96 +/‐ 0.07 mm h); a difference of 20% (95% confidence interval for difference: 1 to 35%; P < 0.05). 4. There was marked intra‐ and intersubject variability in response to ibuprofen over the four treatment periods.(ABSTRACT TRUNCATED AT 250 WORDS)
Wan, SW & Nguyen, HT 1994, '50Hz interference and noise in ECG recordings--a review.', Australas Phys Eng Sci Med, vol. 17, no. 3, pp. 108-115.
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In this review paper, a simplified model is used to explain the various ways by which 50Hz interference can disturb electrocardiogram recordings. From the model, noise expressions are also derived which explain sources of noise in recordings. Means of minimising the 50Hz interference and noise with emphasis placed on skin abrasion and right-leg drive circuits are discussed. An add-on circuit which can be used with existing amplifiers to improve their performance is shown. Previous interference analysis has concentrated on 2-input differential amplifiers, however in modern hospitals, a wide variety of amplifier configurations are used. An example is the Wilson Central Terminal which is used to obtain a zero potential in body surface mapping applications. In this review it is shown with an example for an ECG amplifier incorporating a Wilson Central Terminal, how it is easy to extend the interference model to other applications.
Breit, SN, Robbins, J, Sutherland, G, Por, S & Valenzuela, S 1970, 'The Cloning And Characterization Of A Novel Macrophage Activation Gene', Faseb Journal, Federation Amer Soc Exp Biol, ISI:A1994ND19601234, pp. 1-1.
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NA
GAY, V, LEYDEKKERS, P & INTVELD, RH 1970, 'SPECIFICATION OF AUDIO VIDEO EXCHANGE BASED ON THE REFERENCE MODEL OF ODP', BROADBAND ISLANDS '94 - CONNECTING WITH THE END-USER, 3rd International Conference on Broadband Islands - Connecting with the End-User, ELSEVIER SCIENCE PUBL B V, HAMBURG, GERMANY, pp. 179-191.
Kervella, B, Gay, V & Horlait, E 1970, 'Towards a complete multimedia mail: Use of MHEG in standard messaging systems', Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics), Springer Berlin Heidelberg, pp. 1-13.
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© 1994, Springer Verlag. All Rights Reserved. This paper addresses multimedia aspects in messaging services. It highlights the functionalities that are missing to provide what we call a complete multimedia mail service and it gives standard solutions to integrate those additional functionalities in standard messaging systems. A complete multimedia messaging system does not provide only means to exchange simple multimedia messages having a reasonable size. It should first enable the transfer of multimedia information, directly or by references (e.g. for huge message). In case it uses a reference, files may be retrieved in connected mode. This is, in fact, already included in most messaging systems. Second, it should also be open to the introduction of new media types. This requires the introduction of functionalities to prevent the fact some workstations cannot support those media types. Third, it should enable the composition, the exchange and the presentation of formatted multimedia messages. MIME and X.400-based solutions are presented for the two first issues. For the third issue, we have chosen MHEG as a basis. This future standard is promising and this paper presents how to implement MHEG functionalities in messaging systems.
Leydekkers, P & Gay, V 1970, 'Multimedia Conferencing Services in an Open Distributed Environment.', IWACA, Springer, pp. 339-352.
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© 1994, Springer Verlag. All rights reserved. Distributed Processing Environments (DPE) or platforms are regarded as the future telecommunication architecture [1] on which distributed applications such as Multimedia Conferencing (MMC) services will operate. Using the DPE as target telecommunication platform, an important issue for MMC designers is the specification of generic MMC interfaces. This enables MMC users to access, in a distribution transparent way, a wide range of MMC services, that conform to these interface specifications. This paper proposes a classification of MMC services by means of three generic interface templates. These interface templates describe in an implementation independent way the functionality and management related to MMC services. The paper discusses also a possible implementation of these interfaces. Techniques and concepts are used as proposed by RM-ODP [2] and TINA-C [1].
Logé, C, Gay, V & Horlait, E 1970, 'Computational components for synchronous cooperation on multimedia information', Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics), Springer Berlin Heidelberg, pp. 89-102.
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© 1994, Springer Verlag. All Rights Reserved. Nowadays, the design of cooperative applications is becoming more complex due to the introduction of real time cooperation and multimedia aspects. To ease and accelerate the development of these applications it is necessary to build modular and reusable functional components that can be used by application designers. The objective of this paper is to define some of those functional components. They will be integrated in the cooperative applications to ensure the synchronous cooperation on multimedia objects. For openness and possible wide use in an open distributed heterogeneous environment, the specification of those components is based on the computational language of the Reference Model of Open Distributed Processing (RMODP).
Tuch, BE, Beretov, J, Mackie, JD, Beynon, S, Simpson, AM & Rolph, M 1970, 'Preventing the rejection of grafted human fetal pancreas.', Transplant Proc, United States, p. 704.