Bhattacharya, SK, Crawford, AJ & Pate, JW 1987, 'Electrocardiographic, biochemical, and morphologic abnormalities in dystrophic hamsters with cardiomyopathy', Muscle & Nerve, vol. 10, no. 2, pp. 168-176.
View/Download from: Publisher's site
View description>>
AbstractElectrocardiographic (EKG) changes were investigated in 7‐month‐old dystrophic hamsters (DH) with cardiomyopathy and were correlated with biochemical and histologic aberrations. Abnormally tall R‐I and R‐aVL amplitudes, deep S‐III and S‐aVR waves, and elongated PR‐I, QT‐I, and QRS‐I intervals (all at P <0.0001) were noted in DH compared with normal hamsters. These EKG changes are similar to those seen in Duchenne muscular dystrophy (DMD) and support cardiac hypertrophy (P < 0.001) in DH. Excessive intracellular calcium accumulation in the heart (P < 0.0001), diaphragm (P < 0.001), and rectus femoris (P < 0.05), and elevated plasma creatine kinase concentrations (P < 0.001) were also noted in DH. Histopathology in the cardiac and skeletal muscles of DH included fatty infiltration, centronucleation, and sporadic necrosis with calcium deposition. Observed EKG abnormalities, biochemical alterations, and histological aberrations in the cardiac and skeletal muscles of DH are strikingly similar to those reported in DMD and thus substantiate the relevance of DH as a suitable model for the study of muscular dystrophy and cardiac hypertrophy.
Onslow, M & Ingham, RJ 1987, 'Speech Quality Measurement and the Management of Stuttering', Journal of Speech and Hearing Disorders, vol. 52, no. 1, pp. 2-17.
View/Download from: Publisher's site
View description>>
This paper reviews the various approaches that have been made toward the investigation of speech quality in stuttering treatment. The review takes into account the findings of relevant perceptual and acoustic investigations in the area of normal communication skills and voice disorders. Similar consideration is given to investigations on the stutter-free speech of stutterers where the contribution and relevance of this research to the search for a reliable and viable measure of speech quality is discussed. The review concludes with an overview of some promising findings from recent studies on the use of listener ratings of speech naturalness in the measurement and modification of untreated and treated stutterers. Some avenues for research and issues that have emerged from these studies are also discussed.
PATE, JW 1987, 'MEMBERS OF THE CLUB', SOUTHERN MEDICAL JOURNAL, vol. 80, no. 9, pp. 1199-1199.
