Ajjawi, R, Thistlethwaite, J, Williams, K, Ryan, G, Seale, PJ & Carroll, P 2010, 'Breaking down professional barriers: Medicine and pharmacy students learning together', FOCUS ON HEALTH PROFESSIONAL EDUCATION: A MULTI-DISCIPLINARY JOURNAL, vol. 12, no. 1, pp. 1-10.
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Background: This paper reports findings of a pilot interprofessional problem based learning (PBL) study in the faculties of Medicine and Pharmacy at the University of Sydney, New South Wales. The aim of the research was to investigate whether small group interprofessional learning activities with medical and pharmacy students can lead to: changes in attitude toward each other and toward interprofessional education (IPE); added value when learning together; and better understanding of each other's professional roles. Methods: Nineteen medical and 20 pharmacy students participated in two, 2-hour PBL tutorials focussed on conducting a Home Medicines Review. The Attitudes to Health Professionals Questionnaire (AHPQ) was used to measure attitude change pre- and postinterprofessional PBL. Paired t-tests were used to analyse pre- and post-IPE data. Focus groups were conducted with the students after the PBL sessions. These were audio-recorded, transcribed and analysed. Results: Students reported added value from the IPE experience. Pharmacy students reported a small but significant change in attitude toward the medical students on the AHPQ caring scale, rating them as more caring post-IPE (p=0.001). Although medical students rated the pharmacy students more caring after the intervention, this was not statistically significant (p=0.08). Medical students valued the pharmacy students' input and knowledge. Conclusion: There was evidence of a positive change in students' attitudes to the other profession after only two sessions. Aspects of IPE design such as explicit interprofessional learning outcomes, the use of PBL processes, and relevant learning activities were important to the success of this pilot study
Antoniou, AC, Beesley, J, McGuffog, L, Sinilnikova, OM, Healey, S, Neuhausen, SL, Ding, YC, Rebbeck, TR, Weitzel, JN, Lynch, HT, Isaacs, C, Ganz, PA, Tomlinson, G, Olopade, OI, Couch, FJ, Wang, X, Lindor, NM, Pankratz, VS, Radice, P, Manoukian, S, Peissel, B, Zaffaroni, D, Barile, M, Viel, A, Allavena, A, Dall'Olio, V, Peterlongo, P, Szabo, CI, Zikan, M, Claes, K, Poppe, B, Foretova, L, Mai, PL, Greene, MH, Rennert, G, Lejbkowicz, F, Glendon, G, Ozcelik, H, Andrulis, IL, Thomassen, M, Gerdes, A-M, Sunde, L, Cruger, D, Birk Jensen, U, Caligo, M, Friedman, E, Kaufman, B, Laitman, Y, Milgrom, R, Dubrovsky, M, Cohen, S, Borg, A, Jernström, H, Lindblom, A, Rantala, J, Stenmark-Askmalm, M, Melin, B, Nathanson, K, Domchek, S, Jakubowska, A, Lubinski, J, Huzarski, T, Osorio, A, Lasa, A, Durán, M, Tejada, M-I, Godino, J, Benitez, J, Hamann, U, Kriege, M, Hoogerbrugge, N, van der Luijt, RB, Asperen, CJV, Devilee, P, Meijers-Heijboer, EJ, Blok, MJ, Aalfs, CM, Hogervorst, F, Rookus, M, Cook, M, Oliver, C, Frost, D, Conroy, D, Evans, DG, Lalloo, F, Pichert, G, Davidson, R, Cole, T, Cook, J, Paterson, J, Hodgson, S, Morrison, PJ, Porteous, ME, Walker, L, Kennedy, MJ, Dorkins, H, Peock, S, Godwin, AK, Stoppa-Lyonnet, D, de Pauw, A, Mazoyer, S, Bonadona, V, Lasset, C, Dreyfus, H, Leroux, D, Hardouin, A, Berthet, P, Faivre, L, Loustalot, C, Noguchi, T, Sobol, H, Rouleau, E, Nogues, C, Frénay, M, Vénat-Bouvet, L, Hopper, JL, Daly, MB, Terry, MB, John, EM, Buys, SS, Yassin, Y, Miron, A, Goldgar, D, Singer, CF, Dressler, AC, Gschwantler-Kaulich, D, Pfeiler, G, Hansen, TVO, Jønson, L, Agnarsson, BA, Kirchhoff, T, Offit, K, Devlin, V, Dutra-Clarke, A, Piedmonte, M, Rodriguez, GC, Wakeley, K, Boggess, JF, Basil, J, Schwartz, PE, Blank, SV, Toland, AE, Montagna, M, Casella, C, Imyanitov, E, Tihomirova, L, Blanco, I, Lazaro, C, Ramus, SJ, Sucheston, L, Karlan, BY, Gross, J, Schmutzler, R, Wappenschmidt, B, Engel, C, Meindl, A, Lochmann, M, Arnold, N, Heidemann, S, Varon-Mateeva, R, Niederacher, D, Sutter, C, Deissler, H, Gadzicki, D, Preisler-Adams, S, Kast, K, Schönbuchner, I, Caldes, T, de la Hoya, M, Aittomäki, K, Nevanlinna, H, Simard, J, Spurdle, AB, Holland, H, Chen, X, Platte, R, Chenevix-Trench, G & Easton, DF 2010, 'Common Breast Cancer Susceptibility Alleles and the Risk of Breast Cancer for BRCA1 and BRCA2 Mutation Carriers: Implications for Risk Prediction', Cancer Research, vol. 70, no. 23, pp. 9742-9754.
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Abstract The known breast cancer susceptibility polymorphisms in FGFR2, TNRC9/TOX3, MAP3K1, LSP1, and 2q35 confer increased risks of breast cancer for BRCA1 or BRCA2 mutation carriers. We evaluated the associations of 3 additional single nucleotide polymorphisms (SNPs), rs4973768 in SLC4A7/NEK10, rs6504950 in STXBP4/COX11, and rs10941679 at 5p12, and reanalyzed the previous associations using additional carriers in a sample of 12,525 BRCA1 and 7,409 BRCA2 carriers. Additionally, we investigated potential interactions between SNPs and assessed the implications for risk prediction. The minor alleles of rs4973768 and rs10941679 were associated with increased breast cancer risk for BRCA2 carriers (per-allele HR = 1.10, 95% CI: 1.03–1.18, P = 0.006 and HR = 1.09, 95% CI: 1.01–1.19, P = 0.03, respectively). Neither SNP was associated with breast cancer risk for BRCA1 carriers, and rs6504950 was not associated with breast cancer for either BRCA1 or BRCA2 carriers. Of the 9 polymorphisms investigated, 7 were associated with breast cancer for BRCA2 carriers (FGFR2, TOX3, MAP3K1, LSP1, 2q35, SLC4A7, 5p12, P = 7 × 10−11 − 0.03), but only TOX3 and 2q35 were associated with the risk for BRCA1 carriers (P = 0.0049, 0.03, respectively). All risk-associated polymorphisms appear to interact multiplicatively on breast cancer risk for mutation carriers. Based on the joint genotype distribution of the 7 risk-associated SNPs in BRCA2 mutation carriers, the 5% of BRCA2 carriers at highest risk (i.e., between 95th and 100th percentiles) were predicted to have a probability between 80% and 96% of developing breast cancer by age 80, compared with 42% to 50% for the 5% of carriers at lowest risk. Our findings indicated that these risk differences might be sufficient to influence the clinical management of mutation carriers. Cancer Res; 70(23); 9742–54. ©2010 AACR.
Bailey, PE & Henry, JD 2010, 'Separating component processes of theory of mind in schizophrenia', British Journal of Clinical Psychology, vol. 49, no. 1, pp. 43-52.
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Objective. It has been argued that in order to take the perspective of another the ‘default’ self‐perspective must first be inhibited. Thus, executive function failures (and specifically, reduced inhibitory control of the self‐perspective) may contribute to the theory of mind (ToM) difficulties that have been observed in schizophrenia.Method. Participants with schizophrenia (N=28) and demographically matched controls (N=30) were administered a behavioural measure of ToM that directly manipulates inhibitory demands by involving either high‐ or low‐levels of self‐perspective inhibition.Results. Relative to controls, participants with schizophrenia demonstrated impaired ToM, but did not have particular difficulty on the task that placed high demands on self‐perspective inhibition.Conclusion. Disruption of other‐perspective taking, rather than self‐perspective inhibition, appears to be the more important determinant of ToM impairment in schizophrenia. This finding is discussed in relation to competing perspectives of ToM.
Bailey, PE, Henry, JD, Rendell, PG, Phillips, LH & Kliegel, M 2010, 'Dismantling the “age–prospective memory paradox”: The classic laboratory paradigm simulated in a naturalistic setting', Quarterly Journal of Experimental Psychology, vol. 63, no. 4, pp. 646-652.
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Previous research has identified “the age–prospective memory paradox”—that adult ageing results in reliably poorer performance on laboratory-based tasks of prospective memory (PM), but improved performance on such tasks carried out in real-life settings. We hypothesized that even in their everyday environment, older adults might be worse at PM tasks that are triggered during an experimenter-generated ongoing activity. The present study used a task that captured the key features of the classic laboratory paradigm, but which was completed in a setting that met key criteria to be considered naturalistic. In their everyday setting, participants’ PM was assessed, with the cue to remember occurring either (a) during their day-to-day activities, or (b) during an experimenter-generated ongoing task. The results confirmed previous naturalistic findings, in showing that older adults ( n = 28) exhibited better PM than their younger counterparts ( n = 65) when prompted during their everyday activities. However, older adults were also then subsequently less likely to show effective PM during experimenter-generated ongoing activity. Reproducing the paradox within a single dataset, these data indicate that older adults can effectively act on intentions during everyday activities, but have difficulty in prospective remembering during experimenter-generated ongoing tasks.
Bakker, EWP, Verhagen, AP, van Trijffel, E, Lucas, C & Koes, BW 2010, 'Letters', Spine, vol. 35, no. 13, pp. E576-E577.
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Ball, P & Pont, L 2010, 'Good health not only from GPs', Australian Journal of Pharmacy, vol. 91, no. 1084, p. 38.
Ball, P & Pont, L 2010, 'Rural funding drops academics', Australian Journal of Pharmacy, vol. 91, no. 1082, p. 29.
Ball, P & Pont, L 2010, 'Teamwork in practice', Australian Journal of Pharmacy, vol. 91, no. 1078, p. 28.
Berle, D, Starcevic, V, Milicevic, D, Hannan, A & Moses, K 2010, 'Do Symptom Interpretations Mediate the Relationship Between Panic Attack Symptoms and Agoraphobic Avoidance?', Behavioural and Cognitive Psychotherapy, vol. 38, no. 3, pp. 275-289.
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Background: There is little consensus as to whether agoraphobic avoidance in panic disorder is characterized by a prominence of particular symptoms and interpretations of those symptoms. Aims: We sought to clarify the relationship between symptoms and agoraphobic avoidance and to establish whether catastrophic interpretations of symptoms mediate any such relationships. Method: The Symptom Checklist 90-Revised, Agoraphobic Cognitions Questionnaire and Mobility Inventory were administered to 117 patients with panic disorder who were attending an outpatient anxiety disorders clinic. Results: Medium to large associations were found between most symptoms and agoraphobic avoidance and between particular symptoms and the corresponding symptom interpretation items. Some interpretations of symptoms were found to mediate relationships between symptoms and agoraphobic avoidance. Conclusions: These findings suggest that the catastrophic misinterpretation model of panic disorder can to some extent be invoked to explain the extent of agoraphobic avoidance, but that there may also be other pathways leading from symptoms to agoraphobia.
Berle, D, Starcevic, V, Milicevic, D, Moses, K, Hannan, A, Sammut, P & Brakoulias, V 2010, 'The Factor Structure of the Kessler-10 Questionnaire in a Treatment-Seeking Sample', Journal of Nervous & Mental Disease, vol. 198, no. 9, pp. 660-664.
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Bryce, M & Liu-Brennan, D 2010, 'Japanese Fireworks (Hanabi)', The International Journal of the Arts in Society: Annual Review, vol. 4, no. 5, pp. 189-202.
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Carey, B, O'Brian, S, Onslow, M, Block, S, Jones, M & Packman, A 2010, 'Randomized controlled non‐inferiority trial of a telehealth treatment for chronic stuttering: the Camperdown Program', International Journal of Language & Communication Disorders, vol. 45, no. 1, pp. 108-120.
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Background: Although there are treatments that can alleviate stuttering in adults for clinically significant periods, in Australia there are barriers to the accessibility and availability of best‐practice treatment.Aims: This parallel group, non‐inferiority randomized controlled trial with multiple blinded outcome assessments investigated whether telehealth delivery of the Camperdown Program provides a non‐inferior alternative to face‐to‐face treatment for adults who stutter.Methods & Procedures: Forty participants who presented to a university speech clinic were randomized: 20 to the telehealth arm and 20 to the face‐to‐face arm. Exclusion criteria were age younger than 18 years, frequency of stuttering less than 2% of syllables stuttered and previous speech‐restructuring treatment within the past 12 months. The Camperdown Program for adults who stutter was the intervention. Primary outcome measures were frequency of stuttering measured in per cent syllables stuttered (%SS) before treatment and at 9 months post‐randomization and efficiency, measured by counting the number of speech pathologist contact hours used by each participant. Intention to treat analysis was conducted using last observation carried forward. Secondary outcome measures were speech naturalness, self‐reported stuttering severity, and treatment satisfaction.Outcomes & Results: There was no statistically or clinically significant difference in %SS between the two groups at 9 months post‐randomization. Analysis of covariance adjusting for baseline %SS showed telehealth had 0.8% absolute lower per cent syllables stuttered than face‐to‐face. There were also no differences in %SS between groups immediately post‐treatment, or at 6 months and 12 months post‐treatment (p = 0.9). In the second p...
Chan, CCK, Hodge, C & Sutton, G 2010, 'External analysis of the Randleman Ectasia Risk Factor Score System: a review of 36 cases of post LASIK ectasia', Clinical & Experimental Ophthalmology, vol. 38, no. 4, pp. 335-340.
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AbstractBackground: To validate Randleman's model of ectasia risk factor scores using a large unbiased sample of unpublished cases.Methods: Data were collected retrospectively on 36 eyes with ectasia post laser in situ keratomileusis treated by two surgeons at Vision Eye Institute. The data were then entered into Randleman's risk factor score system. Data were also collected about posterior maximum elevation (PME) and posterior maximum elevation position (PMEP); and these were compared with a control group of 50 eyes.Results: Of the 36 eyes, 9 (25%) were classified as low risk, 7 (19%) as moderate risk and 20 (56%) as high risk. On average, the most points were scored in the topography and topography was abnormal in 69% of cases. Topography points also correlated the most strongly with the increasing risk scores (P < 0.0001). PME or PMEP was not significantly different between our ectasia group and the control group.Conclusion: Randleman's ectasia risk factor scale can miss a significant proportion of patients at risk of ectasia. Other factors must play a role in ectasia risk. Abnormal corneal topography appears to be the most important preoperative risk factor.
Collyer, S, Warren, C, Hemsley, B & Stevens, C 2010, 'Aim, Fire, Aim—Project Planning Styles in Dynamic Environments', Project Management Journal, vol. 41, no. 4, pp. 108-121.
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Rapidly changing environments are a newly recognized and increasing challenge in the field of project management. Traditional prescriptive approaches, oriented around process control, are considered suboptimal in meeting this challenge. In this article, the authors present an exploratory theory-building study aiming to identify the project management approaches used by experienced practitioners to respond to rapidly changing environments. The results of 37 semistructured interviews with 31 participants across 10 industries (i.e., construction, aerospace, international community development, pharmaceutical, defense, film production, start-ups, venture capital, research, and information technology) were analyzed according to the planning styles used. Results are discussed in the light of previous research, and a model for better management in rapidly changing environments is proposed.
Cream, A, O’Brian, S, Jones, M, Block, S, Harrison, E, Lincoln, M, Hewat, S, Packman, A, Menzies, R & Onslow, M 2010, 'Randomized Controlled Trial of Video Self-Modeling Following Speech Restructuring Treatment for Stuttering', Journal of Speech, Language, and Hearing Research, vol. 53, no. 4, pp. 887-897.
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Purpose In this study, the authors investigated the efficacy of video self-modeling (VSM) following speech restructuring treatment to improve the maintenance of treatment effects. Method The design was an open-plan, parallel-group, randomized controlled trial. Participants were 89 adults and adolescents who undertook intensive speech restructuring treatment. Post treatment, participants were randomly assigned to 2 trial arms: standard maintenance and standard maintenance plus VSM. Participants in the latter arm viewed stutter-free videos of themselves each day for 1 month. Results The addition of VSM did not improve speech outcomes, as measured by percent syllables stuttered, at either 1 or 6 months postrandomization. However, at the latter assessment, self-rating of worst stuttering severity by the VSM group was 10% better than that of the control group, and satisfaction with speech fluency was 20% better. Quality of life was also better for the VSM group, which was mildly to moderately impaired compared with moderate impairment in the control group. Conclusions VSM intervention after treatment was associated with improvements in self-reported outcomes. The clinical implications of this finding are discussed.
Crestani, C-AM, Clendon, SA & Hemsley, B 2010, 'Words needed for sharing a story: Implications for vocabulary selection in augmentative and alternative communication', Journal of Intellectual & Developmental Disability, vol. 35, no. 4, pp. 268-278.
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Dancyger, C, Smith, JA, Jacobs, C, Wallace, M & Michie, S 2010, 'Comparing family members’ motivations and attitudes towards genetic testing for hereditary breast and ovarian cancer: a qualitative analysis', European Journal of Human Genetics, vol. 18, no. 12, pp. 1289-1295.
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Duffy, SW, Mackay, J, Thomas, S, Anderson, E, Evans, DG, Fielder, H, Fox, R, Gray, J, Gui, G, Macmillan, D, Moss, S, Rogers, C, Sainsbury, R, Sibbering, M, Boggis, C, Burn, J, Cuzick, J, Haward, B, Howell, A, Mansel, R, Cork, HM, Robertson, J, Patnick, J, Pharoah, P, Robinson, A, Sutton, S, Kataoka, M, Moyle, P, Wallis, M, Warren, R, Jones, EL, Austoker, J, Clements, A, Watson, E, Young, K, Allgood, P, Duffy, P, Gabe, R, Roberts, L, Warsi, I, Caunt, J, Brentnall, A, Dungey, F, Lorincz, A, Offman, J, Adams, M, Affen, J, Aldous, M, Allen, A, Ames, A, Audisio, R, Ashworth, S, Barnes, A, Botham, P, Brown, D, Bullard, S, Carpenter, R, Chorley, W, Christensen, D, Coleman, C, Coe, C, Collier, DSJ, Cooke, J, Cooke, TG, Crichton, R, Crockett, S, Dalgliesh, D, Davies, M, Deacon, C, Douglas, F, Drummond, S, Ebbs, S, Edwardson, J, Elliott, J, Evans, S, Farnon, C, Ferguson, J, Fowler, G, Gallegos, N, Gaskell, C, Gay, J, Gilbert, F, Thomas, KG, Greenhalgh, R, Hansell, D, Mackean, CH, Hartup, S, Hayman, J, Hill, P, Hodgson, S, Holcombe, S, Hogg, M, Hubbard, C, Izatt, L, Jacobs, C, Jmor, S, Jobson, I, Kanani, R, Kent, M, Knight, K, Lannigan, A, Lewis, C, MacArthur, S, Marano, C, Martin, L, Matheson, D, Maurice, A, McClement, J, McCarrick, J, Miedzybrodska, Z, Mortimer, C, Moss, L, Nejim, A, Pallister, D, Paterson, J, Rai, S, Ramm, J, Ravisekar, O, Read, F, Ridley, P, Roche, N, Rockall, L, Rogers, M, Rothnie, N, Rubin, G, Saad, Z, Sheppard, C, Shere, M, dos Santos Silva, I, Simpson, C, Smith, D, Stallard, S, Schuh, KS, Stebbing, A, Steel, J, Stewart, R, Stone, M, Strukowska, O, Tee, E, Taylor, A, Teh, W, Thompson, A, Thompson, WD, Thompson, WO, Toye, R, Turton, P, Vishwanath, L, Walsh, J, Williams, M, Williamson, J, Wise, J, Wise, M, Whitford, P & Zammit, C 2010, 'Mammographic surveillance in women younger than 50 years who have a family history of breast cancer: tumour characteristics and projected effect on mortality in the prospective, single-arm, FH01 study', LANCET ONCOLOGY, vol. 11, no. 12, pp. 1127-1134.
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Engel, C, Versmold, B, Wappenschmidt, B, Simard, J, Easton, DF, Peock, S, Cook, M, Oliver, C, Frost, D, Mayes, R, Evans, DG, Eeles, R, Paterson, J, Brewer, C, McGuffog, L, Antoniou, AC, Stoppa-Lyonnet, D, Sinilnikova, OM, Barjhoux, L, Frenay, M, Michel, C, Leroux, D, Dreyfus, H, Toulas, C, Gladieff, L, Uhrhammer, N, Bignon, Y-J, Meindl, A, Arnold, N, Varon-Mateeva, R, Niederacher, D, Preisler-Adams, S, Kast, K, Deissler, H, Sutter, C, Gadzicki, D, Chenevix-Trench, G, Spurdle, AB, Chen, X, Beesley, J, Olsson, H, Kristoffersson, U, Ehrencrona, H, Liljegren, A, van der Luijt, RB, van Os, TA, van Leeuwen, FE, Domchek, SM, Rebbeck, TR, Nathanson, KL, Osorio, A, Ramón y Cajal, T, Konstantopoulou, I, Benítez, J, Friedman, E, Kaufman, B, Laitman, Y, Mai, PL, Greene, MH, Nevanlinna, H, Aittomäki, K, Szabo, CI, Caldes, T, Couch, FJ, Andrulis, IL, Godwin, AK, Hamann, U & Schmutzler, RK 2010, 'Association of the VariantsCASP8D302H andCASP10V410I with Breast and Ovarian Cancer Risk inBRCA1andBRCA2Mutation Carriers', Cancer Epidemiology, Biomarkers & Prevention, vol. 19, no. 11, pp. 2859-2868.
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AbstractBackground: The genes caspase-8 (CASP8) and caspase-10 (CASP10) functionally cooperate and play a key role in the initiation of apoptosis. Suppression of apoptosis is one of the major mechanisms underlying the origin and progression of cancer. Previous case-control studies have indicated that the polymorphisms CASP8 D302H and CASP10 V410I are associated with a reduced risk of breast cancer in the general population.Methods: To evaluate whether the CASP8 D302H (CASP10 V410I) polymorphisms modify breast or ovarian cancer risk in BRCA1 and BRCA2 mutation carriers, we analyzed 7,353 (7,227) subjects of white European origin provided by 19 (18) study groups that participate in the Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA). A weighted cohort approach was used to estimate hazard ratios (HR) and 95% confidence intervals (95% CI).Results: The minor allele of CASP8 D302H was significantly associated with a reduced risk of breast cancer (per-allele HR, 0.85; 95% CI, 0.76-0.97; Ptrend = 0.011) and ovarian cancer (per-allele HR, 0.69; 95% CI, 0.53-0.89; Ptrend = 0.004) for BRCA1 but not for BRCA2 mutation carriers. The CASP10 V410I polymorphism was not associated with breast or ovarian cancer risk for BRCA1 or BRCA2 mutation carriers.Conclusions: CASP8 D302H decreases breast and ovarian cancer risk for BRCA1 mutation carriers but not for BRCA2 mutation carriers.Impact: The combined application of these and other recently identified genetic risk modifiers could in the future allow better individual risk calculation and could aid in the individualized counseling and decision making with respect to preventive options in BRCA1 mutation carriers. Cancer Epidemiol Biomarkers Prev; 19(11); 2859–68. ©2010 AACR.
FH01 collaborative teams 2010, 'Mammographic surveillance in women younger than 50 years who have a family history of breast cancer: tumour characteristics and projected effect on mortality in the prospective, single-arm, FH01 study', The Lancet Oncology, vol. 11, no. 12, pp. 1127-1134.
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Background
Evidence supports a reduction in mortality from breast cancer with mammographic screening in the general population of women aged 40-49 years, but the effect of family history is not clear. We aimed to establish whether screening affects the disease stage and projected mortality of women younger than 50 years who have a clinically significant family history of breast cancer.
Methods
In the single-arm FH01 study, women at intermediate familial risk who were younger than 50 years were enrolled from 76 centres in the UK, and received yearly mammography. Women with BRCA mutations were not explicitly excluded, but would be rare in this group. To compare the FH01 cohort with women not receiving screening, two external comparison groups were used: the control group of the UK Age Trial (106,971 women aged 40-42 years at recruitment, from the general population [ie, average risk], followed up for 10 years), and a Dutch study of women with a family history of breast cancer (cancer cases aged 25-77 years, diagnosed 1980-2004). Study endpoints were size, node status, and histological grade of invasive tumours, and estimated mortality calculated from the Nottingham prognostic index (NPI) score, and adjusted for differences in underlying risk between the FH01 cohort and the control group of the UK Age Trial. This study is registered with the National Research Register, number N0484114809.
Findings
6710 women were enrolled between Jan 16, 2003, and Feb 28, 2007, and received yearly mammography for a mean of 4 years (SD 2) up until Nov 30, 2009; surveillance and reporting of cancers is still underway. 136 women were diagnosed with breast cancer: 105 (77%) at screening, 28 (21%) symptomatically in the interval between screening events, and three (2%) symptomatically after failing to attend their latest mammogram. Invasive tumours in the FH01 study were significantly smaller (p=0·0094), less likely to be node positive (p=0·0083), and of more favour...
GOFF, S, JACOBS, C, ROBINSON, L & WEBB, P 2010, 'Cancer genetics', European Journal of Cancer Care, vol. 19, no. 4, pp. 424-424.
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Goodhue, R, Onslow, M, Quine, S, O’Brian, S & Hearne, A 2010, 'The Lidcombe Program of early stuttering intervention: mothers’ experiences', Journal of Fluency Disorders, vol. 35, no. 1, pp. 70-84.
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The Lidcombe Program is a behavioral treatment for early stuttering which is implemented by parents, typically the mother. Despite this, there is limited detailed knowledge about mothers' experiences of administering the treatment. This article describes the findings of a qualitative study which explored the experiences of 16 mothers during their implementation of the Lidcombe Program. Information was collected using semi-structured, in-depth, face-to-face and telephone interviews. Participants were interviewed pre-treatment, and then regularly throughout the 6-month treatment period. Data were collected from nine interviews conducted with each participant. All interviews (n=140) were audio recorded and then transcribed verbatim. Thematic analysis was used to identify major issues and topics which emerged from the data.Practicalities of implementing the program are reported, including obstacles that mothers faced and solutions to address these. Positive aspects that mothers experienced through their involvement are discussed. The mothers' perceptions of the treatment are outlined and descriptions of the emotions mothers reported are also presented. Findings from the study will enable clinicians to better deliver the Lidcombe Program and will enable improved course instruction and clinical education about the procedure. Educational objectives: The reader will be able to (1) describe the key components of the Lidcombe Program, (2) describe the rationale and methodology for this study, (3) outline the major findings regarding the mothers' experiences of the Lidcombe Program, (4) describe how the findings can be implemented in a clinical setting and (5) evaluate the strengths and limitations of a qualitative study. © 2010 Elsevier Inc.
Grisham, JR, Henry, JD, Williams, AD & Bailey, PE 2010, 'Socioemotional deficits associated with obsessive–compulsive symptomatology', Psychiatry Research, vol. 175, no. 3, pp. 256-259.
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Haghi, M, Young, PM, Traini, D, Jaiswal, R, Gong, J & Bebawy, M 2010, 'Time- and passage-dependent characteristics of a Calu-3 respiratory epithelial cell model', DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, vol. 36, no. 10, pp. 1207-1214.
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Background: Although standard protocols for the study of drug delivery in the upper airways using the sub-bronchial epithelial cell line Calu-3 model, particularly that of the air-liquid interface configuration, are readily available, the model remains un-validated with respect to culture conditions, barrier integrity, mucous secretion, and transporter function. With respect to the latter, the significance of functional P-glycoprotein (P-gp) activity in Calu-3 cells has recently been questioned, despite previous reports demonstrating a significant contribution by the same transporter in limiting drug uptake across the pulmonary epithelium. Therefore, the aim of this study was the standardization of this model as a tool for drug discovery. Methods: Calu-3 cells were grown using air-interfaced condition (AIC) on polyester cell culture supports. Monolayers were evaluated for transepithelial electrical resistance (TEER), permeability to the paracellular marker fluorescein sodium (flu-Na), surface P-gp expression, and functionality. Mucous secretion was also identified by alcian blue staining. Results: TEER and permeability values obtained for Calu-3 monolayers were shown to plateau between day 5 and day 21 in culture with values reaching 474 ± 44 ωcm2 and 2.33 ± 0.36 × 107 cms, respectively, irrespective of the passage number examined. 32.7 ± 1.49 of Calu-3 cells cultured under these conditions detected positive for cell surface P-gp expression from day 7 onwards. Functional cell surface expression was established by rhodamine 123 drug extrusion assays. Conclusion: This study establishes a clear dependence on culture time and passage number for optimal barrier integrity, mucous secretion, and cell-surface P-gp expression and function in Calu-3 cells. Furthermore it provides initial guidelines for the optimization of this model for high throughput screening applications. © 2010 Informa UK, Ltd.
Hämmerlein, A, Müller, U & Schulz, M 2010, 'Versorgungsmanagement für Menschen mit Asthma – Einbindung der Apotheker', Zeitschrift für Evidenz, Fortbildung und Qualität im Gesundheitswesen, vol. 104, no. 2, pp. 92-98.
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Harper, SJ, McEwen, AR & Dennett, ER 2010, 'Immunohistochemical testing for colon cancer--what do New Zealand surgeons know?', N Z Med J, vol. 123, no. 1325, pp. 35-40.
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AIM: 8-12% of colorectal cancers are associated with genetic syndromes. The most common of these is Lynch syndrome (also known as Hereditary Non-Polyposis Colorectal Cancer). Clinical criteria (Besthesda criteria) exist that can be used to identify colorectal cancer patients who may benefit from immunohistochemical screening of their tumour for Lynch syndrome. Treating surgeons need to know these criteria in order to request appropriate testing. The aim of this study was to assess the knowledge of New Zealand surgeons about the Bethesda criteria. METHODS: We conducted a postal survey of all New Zealand General Surgical Fellows of the Royal Australasian College of Surgeons. RESULTS: Of the surgeons returning surveys 88% knew screening using immunohistochemistry was available; 7% would not refer an abnormal result to a genetic service. Results of the practice based questions showed only 45% of respondents knew that a colorectal cancer diagnosed before the age of 50 was one of the Besthesda criteria. The correct response rates for the rest of the survey ranged from 32-96%. Questions about Lynch syndrome associated cancers returned fewest correct answers. In general, surgeons are poorly informed about cancers associated with Lynch syndrome. CONCLUSION: The study demonstrates limited awareness of the Besthesda criteria amongst New Zealand General Surgeons. Those treating colorectal cancer should be aware of the classic features of Lynch syndrome and test appropriately.
Henry, JD, Bailey, PE, von Hippel, C, Rendell, PG & Lane, A 2010, 'Alexithymia in schizophrenia', Journal of Clinical and Experimental Neuropsychology, vol. 32, no. 8, pp. 890-897.
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Henschke, N, Kuijpers, T, Rubinstein, SM, van Middelkoop, M, Ostelo, R, Verhagen, A, Koes, BW & van Tulder, MW 2010, 'Injection therapy and denervation procedures for chronic low-back pain: a systematic review', European Spine Journal, vol. 19, no. 9, pp. 1425-1449.
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Hordijk, J, Luijsterburg, P, Koes, B & Verhagen, A 2010, 'Prognostische factoren bij een lumbosacraal radiculair syndroom', Huisarts en wetenschap, vol. 53, no. 9, pp. 474-478.
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Background: Little is known about the course of lumbosacral radiculopathy and its rate of persistence or recurrence. We therefore investigated what proportion of patients with acute lumbosacral radiculopathy undergo surgery or have persistent complaints in the long term. We also investigated prognostic factors for surgery and/or recurrent symptoms and complaints. Methods: In this long-term follow-up of patients with symptoms of acute lumbosacral radiculopathy in general practice, patients were invited to participate in a telephone interview about 3 years after the start of the study. Prognostic factors were determined by means of univariate and multivariate logistic regression analysis. Results: Of 135 eligible patients, 96 (71.1%) participated in the study. Seven patients underwent surgery, all during the first year. At 3-year follow-up, about one third of the patients reported experiencing "leg symptoms in the past week", and almost all patients reported having new episodes of back pain. More than half of the patients reported new episodes of leg pain. Fifty-seven patients (59.3%) had recurrent symptoms and 4 (4.2%) patients had persistent symptoms. Heavy labour and functional disability at baseline were associated with persistent symptoms, and pain severity at baseline was predictive of future surgery. Conclusions: Many patients with acute lumbosacral radiculopathy experienced recurrent symptoms during this 3-year follow-up study, and seven patients (5.2%) underwent surgery within a year of symptom onset.
Husson, EC, Ribbers, GM, Willemse-van Son, AHP, Verhagen, AP & Stam, HJ 2010, 'Prognosis of six-month functioning after moderate to severe traumatic brain injury: a systematic review of prospective cohort studies', Journal of Rehabilitation Medicine, vol. 42, no. 5, pp. 425-436.
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Iverach, L, Jones, M, O’Brian, S, Block, S, Lincoln, M, Harrison, E, Hewat, S, Menzies, RG, Packman, A & Onslow, M 2010, 'Mood and Substance Use Disorders Among Adults Seeking Speech Treatment for Stuttering', Journal of Speech, Language, and Hearing Research, vol. 53, no. 5, pp. 1178-1190.
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Objectives Stuttering has been associated with a range of anxiety disorders, including social phobia. In the general community, anxiety disorders are frequently associated with increased rates of mood and substance use disorders. Therefore, in the present study, the authors sought to determine the rate of mood and substance use disorders among adults who stutter. Method The study employed a matched case–control design. Participants included 92 adults seeking treatment for stuttering and 920 age- and gender-matched controls. Mental health assessments were conducted via a computerized psychiatric diagnostic interview. Conditional logistic regression models were used to estimate odds ratios for the prevalence of mood and substance use disorders in both groups. Results When compared with matched controls, adults seeking treatment for stuttering had twofold increased odds of meeting criteria for a 12-month diagnosis of any mood disorder but were not found to report significantly higher lifetime prevalence rates for any substance use disorder. Conclusions Although adults who stutter in the present study were characterized by significantly higher rates of mood disorders than matched controls, they do not appear to self-medicate with substances such as alcohol. Results are discussed in terms of treatment implications and possible reasons why adults who stutter may avoid alcohol.
Iverach, L, O’Brian, S, Jones, M, Block, S, Lincoln, M, Harrison, E, Hewat, S, Menzies, RG, Packman, A & Onslow, M 2010, 'The Five Factor Model of personality applied to adults who stutter', Journal of Communication Disorders, vol. 43, no. 2, pp. 120-132.
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Previous research has not explored the Five Factor Model of personality among adults who stutter. Therefore, the present study investigated the five personality domains of Neuroticism, Extraversion, Openness, Agreeableness and Conscientiousness, as measured by the NEO Five Factor Inventory (NEO-FFI), in a sample of 93 adults seeking speech treatment for stuttering, and compared these scores with normative data from an Australian and a United States sample. Results revealed that NEO-FFI scores for the stuttering group were within the 'average' range for all five personality domains. However, adults who stutter were characterized by significantly higher Neuroticism, and significantly lower Agreeableness and Conscientiousness, than normative samples. No significant differences were found between groups on the dimensions of Extraversion and Openness. These results are discussed with reference to the relationship between personality factors among adults who stutter, their directionality, and implications for predicting treatment outcome. Learning outcomes: The reader will be able to: (1) describe the Five Factor Model of personality, including the NEO-FFI personality domains of Extraversion, Neuroticism, Openness, Agreeableness, and Conscientiousness, and (2) discuss differences in NEO-FFI domain scores between adults who stutter and normative samples, and (3) understand the clinical implications of personality profiles in terms of treatment process and outcome for adults who stutter. © 2009 Elsevier Inc.
Karels, CH, Bierma-Zeinstra, SM, Verhagen, AP, Koes, BW & Burdorf, A 2010, 'Sickness absence in patients with arm, neck and shoulder complaints presenting in physical therapy practice: 6 months follow-up', Manual Therapy, vol. 15, no. 5, pp. 476-481.
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Kilov, AM, Togher, L, Power, E & Turkstra, L 2010, 'Can teenagers with traumatic brain injury use Internet chatrooms? A systematic review of the literature and the Internet', Brain Injury, vol. 24, no. 10, pp. 1135-1172.
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Kneebone, I, Baker, J & O'Malley, H 2010, 'Screening for Depression after Stroke: Developing Protocols for the Occupational Therapist', British Journal of Occupational Therapy, vol. 73, no. 2, pp. 71-76.
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Depression after stroke is common and can have a substantial effect on rehabilitation outcome. Despite this, the routine screening that has been recommended is only taking place around half the time. Occupational therapists have training that well positions them to provide screening. In a local stroke unit, the psychology and occupational therapy departments worked together, considering relevant research, clinical considerations (such as identifying suicidal ideas) and practical issues (such as ease of administration and patient compliance) to determine screening protocols that could be enacted by occupational therapists. Two protocols were developed, one for people under 65 years of age and one for people aged 65 years or older.
Kneebone, II, Hurn, JS, Raisbeck, E, Cropley, M, Khoshnaw, H & Milton, JE 2010, 'The Validity of Goal Achievement as an Outcome Measure in Physical Rehabilitation Day Hospitals for Older People', International Journal of Disability, Development and Education, vol. 57, no. 2, pp. 145-153.
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Langevin, M, Packman, A & Onslow, M 2010, 'Parent perceptions of the impact of stuttering on their preschoolers and themselves', Journal of Communication Disorders, vol. 43, no. 5, pp. 407-423.
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Speech-language pathologists (SLPs) are advised to consider the distress of preschoolers and parents along with the social consequences of the child's stuttering when deciding whether to begin or delay treatment. Seventy-seven parents completed a survey that yielded quantitative and qualitative data that reflected their perceptions of the impact of stuttering on their children and themselves. Sixty-nine (89.6%) parents reported between 1 and 13 types of negative impact (modal. =2). The most frequently reported reactions of children were frustration associated with their stuttering, withdrawal, reduced or changed verbal output, making comments about their inability to talk, and avoidances. The most frequently reported peer reaction was teasing (27.3%). Seventy parents (90.9%) reported that they were affected by their child's stuttering. Their most frequently reported reactions were worry/anxiety/concern, uncertainty about what to do, frustration, upset (parent term), self-blame (fear that they had caused the stuttering), taking time to listen, waiting for the child to finish talking, modifying their own speech, and asking the child to modify speech. Findings support calls for SLPs to consider the distress of preschool children and their parents and the social consequences of the children's stuttering when making the decision to begin or delay treatment.Learning outcomes: Readers will be able to describe parents' perceptions of the impact of stuttering on their children and themselves. In particular, readers will learn about (1) parents' perceptions of young children's awareness and reactions to their stuttering, (2) parents' perceptions of the social consequences of stuttering for young children; and (2) the emotional effect of stuttering on parents. © 2010.
Lincoln, M, Packman, A, Onslow, M & Jones, M 2010, 'An Experimental Investigation of the Effect of Altered Auditory Feedback on the Conversational Speech of Adults Who Stutter', Journal of Speech, Language, and Hearing Research, vol. 53, no. 5, pp. 1122-1131.
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Purpose To investigate the impact on percentage of syllables stuttered of various durations of delayed auditory feedback (DAF), levels of frequency-altered feedback (FAF), and masking auditory feedback (MAF) during conversational speech. Method Eleven adults who stuttered produced 10-min conversational speech samples during a control condition and under 4 different combinations of DAF, FAF, and MAF. Participants also read aloud in a control condition with DAF and FAF. Results A statistically significant difference was found between the NAF conversation condition and the 4 combined altered auditory feedback (AAF) conditions. No statistically significant differences in percentage of syllables stuttered were found in conversation or reading between the control conditions and the FAF/DAF or MAF conditions. The analysis of individual participants' data showed highly individual responsiveness to different conditions. Conclusions Participants' varying responses to differing AAF settings likely accounted for the failure to find group differences between conditions. These results suggest that studies that use standard DAF and FAF settings for all participants are likely to underestimate any AAF effect. It is not yet possible to predict who will benefit from AAF devices in everyday situations and the extent of those benefits.
Logghe, IHJ, Verhagen, AP, Rademaker, ACHJ, Bierma-Zeinstra, SMA, van Rossum, E, Faber, MJ & Koes, BW 2010, 'The effects of Tai Chi on fall prevention, fear of falling and balance in older people: A meta-analysis', Preventive Medicine, vol. 51, no. 3-4, pp. 222-227.
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Mealing, NM, Banks, E, Jorm, LR, Steel, DG, Clements, MS & Rogers, KD 2010, 'Investigation of relative risk estimates from studies of the same population with contrasting response rates and designs', BMC Medical Research Methodology, vol. 10, no. 1.
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Background. There is little empirical evidence regarding the generalisability of relative risk estimates from studies which have relatively low response rates or are of limited representativeness. The aim of this study was to investigate variation in exposure-outcome relationships in studies of the same population with different response rates and designs by comparing estimates from the 45 and Up Study, a population-based cohort study (self-administered postal questionnaire, response rate 18%), and the New South Wales Population Health Survey (PHS) (computer-assisted telephone interview, response rate ∼60%). Methods. Logistic regression analysis of questionnaire data from 45 and Up Study participants (n = 101,812) and 2006/2007 PHS participants (n = 14,796) was used to calculate prevalence estimates and odds ratios (ORs) for comparable variables, adjusting for age, sex and remoteness. ORs were compared using Wald tests modelling each study separately, with and without sampling weights. Results. Prevalence of some outcomes (smoking, private health insurance, diabetes, hypertension, asthma) varied between the two studies. For highly comparable questionnaire items, exposure-outcome relationship patterns were almost identical between the studies and ORs for eight of the ten relationships examined did not differ significantly. For questionnaire items that were only moderately comparable, the nature of the observed relationships did not differ materially between the two studies, although many ORs differed significantly. Conclusions. These findings show that for a broad range of risk factors, two studies of the same population with varying response rate, sampling frame and mode of questionnaire administration yielded consistent estimates of exposure-outcome relationships. However, ORs varied between the studies where they did not use identical questionnaire items. © 2010 Mealing et al; licensee BioMed Central Ltd.
Mehta, P, Singh, J & Vij, J 2010, 'Efficacy of Intensive Neurodevelopment Therapy versus Conventional Physiotherapy in children with spastic cerebral palsy', Indian journal of physiotherapy and occupational therapy.
O'Brian, S, Jones, M, Pilowsky, R, Onslow, M, Packman, A & Menzies, R 2010, 'A new method to sample stuttering in preschool children', International Journal of Speech-Language Pathology, vol. 12, no. 3, pp. 173-177.
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This study reports a new method for sampling the speech of preschool stuttering children outside the clinic environment. Twenty parents engaged their stuttering children in an everyday play activity in the home with a telephone handset nearby. A remotely located researcher telephoned the parent and recorded the play session with a phone-recording jack attached to a digital audio recorder at the remote location. The parent placed an audio recorder near the child for comparison purposes. Children as young as 2 years complied with the remote method of speech sampling. The quality of the remote recordings was superior to that of the in-home recordings. There was no difference in means or reliability of stutter-count measures made from the remote recordings compared with those made in-home. Advantages of the new method include: (1) cost efficiency of real-time measurement of percent syllables stuttered in naturalistic situations, (2) reduction of bias associated with parent-selected timing of home recordings, (3) standardization of speech sampling procedures, (4) improved parent compliance with sampling procedures, (5) clinician or researcher on-line control of the acoustic and linguistic quality of recordings, and (6) elimination of the need to lend equipment to parents for speech sampling. © 2010 The Speech Pathology Association of Australia Limited.
Peterson-Clark, G, Aslani, P & Williams, KA 2010, 'Consumer use of the internet for medicines information', International Journal of Pharmacy Practice, vol. 12, no. 4, pp. 185-190.
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Abstract Objective To explore consumer opinion of the internet as a source of medicines information, the reasons consumers use this information, and the impact of this information on their use of medicines. Method Focus groups (n=6) were conducted in metropolitan Sydney, Australia during March to May 2003 with consumers (n=46) who had used the internet for medicines information. Key findings Although participants expressed some concerns about the quality of internet-based medicines information (IBMI), the convenience of access to this information outweighed these reservations. Attitudes were thus positive overall. Participants used IBMI when preparing for doctors' visits, for second opinions and additional information, for information on current issues, when deciding whether to use a medicine, for comparative information on brands and generics, and when written information was not supplied by health professionals. Most participants felt empowered by the information they found and used it to play a more active role in decision making about their therapy. Conclusion This study describes various issues associated with consumer use of IBMI and highlights the possible role of pharmacists to support their patients' efforts to access and interpret medicines information.
Peterson‐Clark, G, Aslani, P & Williams, KA 2010, 'Pharmacists’ online information literacy: an assessment of their use of Internet‐based medicines information', Health Information & Libraries Journal, vol. 27, no. 3, pp. 208-216.
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AbstractIntroduction: Pharmacists need effective skills in accessing and using Internet‐based medicines information (IBMI) for themselves and their consumers. However, there is limited information regarding how pharmacists use the Internet.Objectives: To develop and use a research instrument to measure pharmacists’ Internet knowledge, search skills, evaluation of and opinions about using IBMI.Methods: A structured questionnaire examining general Internet knowledge, ability to search for and select pertinent IBMI, evaluation of IBMI, opinions about using IBMI and current Internet use was developed. Exploratory factor analysis was performed to analyse IBMI evaluation.Results: 208 pharmacists responded (response rate 20.6%). There was a large variation in pharmacists’ scores. Mean scores were low for General Internet Knowledge (mean 7.91 ± 3.62; scale 0–16), Search and Selection of IBMI (4.98 ± 2.91; 0–10) and Opinions on IBMI (44.51 ± 9.61; 0–80). Four factors [Professionalism of website (4 items; factor loading 0.62–0.87; Cronbach’s α 0.84), Disclosure (5; 0.37–0.79; 0.73), Appropriateness of content (5; 0.32–0.50; 0.65), Standard of information (6; 0.31–0.48; 0.58)] were extracted from the evaluation scale, explaining 36.89% of the total variance.Conclusions: A tool was developed to evaluate pharmacists’ skills and opinions in using IBMI. A wide range of skills and opinions highlighted the need for training in online information literacy.
Pichert, G, Jacobs, C, Jacobs, I, Menon, U, Manchanda, R, Johnson, M, Hamed, H, Firth, C, Evison, M, Tutt, A, de Silva, L, Langman, C & Izatt, L 2010, 'Novel one-stop multidisciplinary follow-up clinic significantly improves cancer risk management in BRCA1/2 carriers', Familial Cancer, vol. 9, no. 3, pp. 313-319.
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Porter, G, Starcevic, V, Berle, D & Fenech, P 2010, 'Recognizing Problem Video Game Use', Australian & New Zealand Journal of Psychiatry, vol. 44, no. 2, pp. 120-128.
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Objectives: It has been increasingly recognized that some people develop problem video game use, defined here as excessive use of video games resulting in various negative psychosocial and/or physical consequences. The main objectives of the present study were to identify individuals with problem video game use and compare them with those without problem video game use on several variables. Method: An international, anonymous online survey was conducted, using a questionnaire with provisional criteria for problem video game use, which the authors have developed. These criteria reflect the crucial features of problem video game use: preoccupation with and loss of control over playing video games and multiple adverse consequences of this activity. Results: A total of 1945 survey participants completed the survey. Respondents who were identified as problem video game users (n = 156, 8.0%) differed significantly from others (n = 1789) on variables that provided independent, preliminary validation of the provisional criteria for problem video game use. They played longer than planned and with greater frequency, and more often played even though they did not want to and despite believing that they should not do it. Problem video game users were more likely to play certain online role-playing games, found it easier to meet people online, had fewer friends in real life, and more often reported excessive caffeine consumption. Conclusions: People with problem video game use can be identified by means of a questionnaire and on the basis of the present provisional criteria, which require further validation. These findings have implications for recognition of problem video game users among individuals, especially adolescents, who present to mental health services. Mental health professionals need to acknowledge the public health significance of the multiple negative consequences of problem video game use.
Roberts, AS, Benrimoj, SIC, Chen, TF, Williams, KA & Aslani, P 2010, 'Implementing cognitive services in community pharmacy: a review of facilitators used in practice change', International Journal of Pharmacy Practice, vol. 14, no. 3, pp. 163-170.
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AbstractObjectiveTo investigate facilitators of change in community pharmacy and their use in the implementation of cognitive pharmaceutical services (CPS).MethodRelevant literature published in English was identified through searches of online databases (no date limits), texts, conference proceedings, and bibliographies of identified literature. Literature that involved a discussion of facilitators of community pharmacy practice change in relation to the implementation and/or delivery of CPS was selected for review. Some of the identified studies were conceptual in nature, and although they were selected in the same way as the empirical research papers, were not able to be critically reviewed in an equivalent manner. A narrative, rather than systematic review, was considered more appropriate.Key findingsThe identified facilitators exist at two levels: the individual (e.g. knowledge) and the organisation (e.g. pharmacy layout). Few studies identified or measured facilitators drawn from experience, with many based on the views of researchers or participants in the studies, in reaction to identified barriers to CPS implementation. Purposive sampling was common in the reviewed studies, limiting the generalisability of the findings.ConclusionAlthough a number of facilitators have been identified in the literature, it appears that little consideration has been given to how they can best be used in practice to accelerate CPS implementation. Identifying facilitators at both individual and organisational levels is important, and future research should focus not only on their identification in representative populations, but on how they should be incorporated into programmes for CPS delivery.
Rubinstein, SM, van Middelkoop, M, Kuijpers, T, Ostelo, R, Verhagen, AP, de Boer, MR, Koes, BW & van Tulder, MW 2010, 'A systematic review on the effectiveness of complementary and alternative medicine for chronic non-specific low-back pain', European Spine Journal, vol. 19, no. 8, pp. 1213-1228.
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Sabater-Hernández, D, Faus, MJ, Fikri-Benbrahim, N & García-Cárdenas, V 2010, 'Resultados globales de la base de datos del Programa Dáder de Seguimiento Farmacoterapéutico: 2008', Atención Primaria, vol. 42, no. 5, pp. 297-298.
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Sabater-Hernandez, D, Jose Faus, M, Fikri-Benbrahim, N & Garcia-Cardenas, V 2010, 'Overall results of the Dader Pharmacotherapeutic Follow-Up Program data base: 2008', ATENCION PRIMARIA, vol. 42, no. 5, pp. 297-298.
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Schellingerhout, JM & Verhagen, AP 2010, 'Letter to the Editor concerning “Development of a clinical prediction rule to identify patients with neck pain likely to benefit from cervical traction and exercise” by Raney N et al. (2009) Eur Spine J 18:382–391', European Spine Journal, vol. 19, no. 5, pp. 833-833.
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Schellingerhout, JM, Heymans, MW, Verhagen, AP, Lewis, M, de Vet, HCW & Koes, BW 2010, 'Prognosis of Patients With Nonspecific Neck Pain', Spine, vol. 35, no. 17, pp. E827-E835.
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Seymour, K, Clifford, CWG, Logothetis, NK & Bartels, A 2010, 'Coding and Binding of Color and Form in Visual Cortex', Cerebral Cortex, vol. 20, no. 8, pp. 1946-1954.
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Smith, K, McCabe, P, Togher, L, Power, E, Munro, N, Murray, E & Lincoln, M 2010, 'An introduction to the speechBITE database: Speech pathology database for best interventions and treatment efficacy', Evidence-Based Communication Assessment and Intervention, vol. 4, no. 3, pp. 148-159.
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This paper describes the development of the Speech Pathology Database for Best Interventions and Treatment Efficacy (speechBITE) at The University of Sydney. The speechBITE database is designed to provide better access to the intervention research relevant to speech pathology and to help clinicians interpret treatment research. The challenges speech pathologists face when locating research to support evidence-based practice have been well documented and include inadequate time resources and difficulties in navigating and using a multiplicity of electronic databases. These barriers are addressed by speechBITE by providing the first open-access database on the internet that solely indexes treatment in the area of communication and swallowing disorders. The database includes the bibliographic details from systematic reviews, randomized controlled trials, nonrandomized controlled trials, case series, and singlecase experimental design studies. At present, randomized and nonrandomized controlled trials are rated with the Physiotherapy Evidence Database (PEDro) scale to assist clinicians with interpreting the methodological quality of the clinical studies of relevance to speech pathologists. © 2010 Psychology Press, an imprint of the Taylor & Francis Group.
Taylor, S, Maharaj, P, Williams, K, Chetty, M & Sheldrake, C 2010, 'Pharmacy students' perspectives and performance following inter-campus lecture delivery via video conferencing', FOCUS ON HEALTH PROFESSIONAL EDUCATION: A MULTI-DISCIPLINARY JOURNAL, vol. 12, no. 1, pp. 39-51.
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The University of Sydney offered the Bachelor of Pharmacy (Rural) from 2003 at its campus in Orange, New South Wales. The degree was designed to help address a shortfall in the rural pharmacy workforce by training pharmacists in a rural setting and by providing greater rural content in the curriculum. Where appropriate, lectures given to students enrolled in the Bachelor of Pharmacy in Sydney were delivered via video-conferencing to the campus in Orange. Aims: To evaluate four units of study with respect to students' views on video-conferencing of lectures, and to compare students' performance to determine whether students receiving tuition via video-conferencing were disadvantaged compared to students receiving face-to-face tuition. Methods: Students in Sydney and Orange were surveyed using a six-item questionnaire. All statements focused on video-conferencing and required students to score their responses on a 5-point Likert-type rating scale. Means were calculated for each item. End of semester mean marks were compared, as well as the proportion of students passing in each cohort. Results: Students in Orange felt it was difficult to ask questions via video-conferencing. They also felt that lectures needed to be supplemented with face-to-face tutorials and that some lectures should be delivered from Orange. Students in Sydney felt that video-conferencing to Orange disrupted their classes and did not want to receive lectures video-conferenced from Orange. Marks for students in Orange were generally lower than those of the Sydney cohort, but there were no statistically significant differences in the proportion of students who passed each unit. Conclusion: The configuration of the lecture theatre and the opportunity for the remote students to interact with lecturers strongly affects student satisfaction. In addition, there is a need for expert technical back-up at all sites and for staff development and support on ways to effectively use this technology
Togher, L, Power, E, Tate, R, McDonald, S & Rietdijk, R 2010, 'Measuring the social interactions of people with traumatic brain injury and their communication partners: The adapted Kagan scales', Aphasiology, vol. 24, no. 6-8, pp. 914-927.
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Trajkovski, N, Andrews, C & Packman, A 2010, 'Parents as therapists in early stuttering intervention', ACQuiring Knowledge in Speech, Language and Hearing, vol. 12, no. 2.
Vaccaro, LD, Jones, MK, Menzies, RG & Wootton, BM 2010, 'Danger Ideation Reduction Therapy for Obsessive–Compulsive Checking: Preliminary Findings', Cognitive Behaviour Therapy, vol. 39, no. 4, pp. 293-301.
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Danger Ideation Reduction Therapy (DIRT) is a cognitive treatment package developed in the mid-1990s to treat obsessive-compulsive (OC) washing. DIRT is solely directed at decreasing threat expectancies and does not involve direct or indirect exposure. The effectiveness of the DIRT package for OC washers has been examined, and to date a number of publications, including two randomised controlled trials, support its efficacy. Recently, the DIRT package was modified to treat people with the OC checking subtype. In the current study, three adult OC checkers received DIRT in 12 to 14 individual 1-hr sessions conducted by a clinical psychologist. At posttreatment, substantial and clinically significant reductions in scores on a range of standardized outcome measures of obsessive-compulsive disorder symptom severity were apparent for all three participants. Crucially, these improvements were maintained at 4-month follow-up. Although further research is clearly warranted, these preliminary findings suggest that DIRT for checkers may prove as effective as DIRT for OC washers. © 2010 Taylor & Francis.
van der Windt, DAWM, Simons, E, Riphagen, II, Ammendolia, C, Verhagen, AP, Laslett, M, Devillé, W, Deyo, RA, Bouter, LM, de Vet, HCW & Aertgeerts, B 2010, 'Physical examination for lumbar radiculopathy due to disc herniation in patients with low-back pain', Cochrane Database of Systematic Reviews, no. 2.
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van Middelkoop, M, Rubinstein, SM, Verhagen, AP, Ostelo, RW, Koes, BW & van Tulder, MW 2010, 'Exercise therapy for chronic nonspecific low-back pain', Best Practice & Research Clinical Rheumatology, vol. 24, no. 2, pp. 193-204.
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VARCIN, KJ, BAILEY, PE & HENRY, JD 2010, 'Empathic deficits in schizophrenia: The potential role of rapid facial mimicry', Journal of the International Neuropsychological Society, vol. 16, no. 4, pp. 621-629.
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AbstractEmotional facial expressions evoke rapid, involuntary, and covert facial reactions in the perceiver that are consistent with the emotional valence of the observed expression. These responses are believed to be an important low-level mechanism contributing to the experience of empathy, which some have argued rely on a simulation mechanism subserved by the human mirror neuron system (MNS). Because schizophrenia is associated with pervasive social cognitive difficulties which have been linked to structural abnormalities in the MNS network, the aim of the present study was to provide the first assessment of how rapid facial mimicry reactions (within 1000 ms poststimulus onset) are affected in schizophrenia. Activity in thecorrugator superciliiandzygomaticus majormuscle regions was quantified using electromyography while individuals with schizophrenia (n= 25) and controls (n= 25) viewed images of happy and angry facial expressions. In contrast to controls, individuals with schizophrenia demonstrated atypical facial mimicry reactions which were not associated with any clinical features of the disorder. These data provide evidence for a low-level disruption that may be contributing to empathizing deficits in schizophrenia and are discussed in relation to neuropsychological models of empathy and schizophrenia. (JINS, 2010,16, 621–629.)
Verhagen, AP & Schellingerhout, JM 2010, 'Low-level laser therapy for neck pain', The Lancet, vol. 375, no. 9716, pp. 721-721.
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Verhagen, AP, Damen, L, Berger, MY, Lenssinck, MLB, Passchier, J & Koes, BW 2010, 'Treatment of tension headache: Paracetamol and NSAIDs do work - A systematic review', Nederlands Tijdschrift voor Geneeskunde, vol. 154, no. 27, pp. 1268-1273.
Verhagen, AP, Damen, L, Berger, MY, Lenssinck, M-LB, Passchier, J & Kroes, BW 2010, '[Treatment of tension type headache: paracetamol and NSAIDs work: a systematic review].', Ned Tijdschr Geneeskd, vol. 154, no. 27, p. A1924.
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OBJECTIVE: Tension-type headache (TTH), also known as tension headache or muscle contraction headache is the most commonly experienced type of headache. Our aim was to evaluate the effectiveness of interventions in patients with TTH. METHOD: We performed a systematic review according to the guidelines of the Cochrane Collaboration. Randomised trials reporting conservative treatments in patients with TTH with headache as outcome were included. In the analysis studies were grouped according to type of intervention: acute pain medication, preventive medication, physiotherapy interventions, behavioural interventions and interventions in children. RESULTS: A total of 152 trials were included in this review with 17.523 patients, of which 37 studies (24.3%) were considered to be of high quality. Nine studies could not be included in one of the five subgroups. ACUTE MEDICATION: (41 trials). The pooled analyses showed that NSAIDs and acetaminophen are more effective than placebo. No significant differences could be found between different types of NSAIDs, but ibuprofen showed fewer short-term side effects when compared to other NSAIDs. There was a significant difference in favour of NSAIDs when compared to acetaminophen. PREVENTIVE MEDICATION: (44 trials). Overall, the use of antidepressants does not show to be more effective than placebo, and no significant differences between different types of antidepressants were found. Furthermore there is limited evidence concerning the negative effects of propranolol on depression in TTH patients, when compared to placebo or biofeedback. There is conflicting evidence about the effectiveness of benzodiazepines and vasodilator agents compared to placebo. There is no evidence concerning the effectiveness of muscle relaxants compared to placebo. BEHAVIOURAL THERAPY: (44 trials). Eight studies compared relaxation treatment with a waiting list or attention placebo control, and 11 studies compared EMG biofeedback with placebo an...
Verhagen, AP, Damen, L, Berger, MY, Passchier, J & Koes, BW 2010, 'Lack of benefit for prophylactic drugs of tension-type headache in adults: a systematic review', Family Practice, vol. 27, no. 2, pp. 151-165.
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Verhagen, AP, Karels, CH, Schellingerhout, JM, Willemsen, SP, Koes, BW & Bierma-Zeinstra, SMA 2010, 'Pain severity and catastrophising modify treatment success in neck pain patients in primary care', Manual Therapy, vol. 15, no. 3, pp. 267-272.
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Weaver, MD, Phillips, J & Lauwereyns, J 2010, 'Semantic Influences from a Brief Peripheral Cue Depend on Task Set', Quarterly Journal of Experimental Psychology, vol. 63, no. 7, pp. 1249-1255.
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Previous research has shown semantic influence from irrelevant peripheral cues on the spatial allocation of covert visual attention. The present study explored whether the task set determines the extent of such semantic influence. A spatial cueing paradigm with strict eye movement control was used, where cues were either first names (male or female) or emotionally charged words (positive or negative) followed by a face target. Participants discriminated either the gender (male or female) or the emotion (positive or negative) of the face. When there was high information overlap between cue and task set, responses were faster when the cue and target value were semantically congruent than when they were incongruent. It was concluded that the semantically related cues primed a task-influencing response independently of spatial attention allocation processes, showing that semantic influences from brief peripheral cues depend on the degree of information overlap between cue and task set.
Wootton, BM & Titov, N 2010, 'Distance Treatment of Obsessive–Compulsive Disorder', Behaviour Change, vol. 27, no. 2, pp. 112-118.
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AbstractObsessive–compulsive disorder (OCD) is an important mental health problem. The Australian National Survey of Mental Health and Wellbeing estimates the 12-month prevalence of OCD is 1.9% (Australian Bureau of Statistics, 2007). Individuals with OCD experience considerable impairment in daily functioning. Cognitive and behavioural therapy for OCD has been shown to be effective, however, accessibility to evidence based treatments is limited in Australia, especially for those living in rural and remote communities. Treatment delivered in a remote fashion may improve accessibility to such treatments. The present review aimed to evaluate the current status of evidence based treatments for OCD delivered remotely.
