Antoniou, AC, Kartsonaki, C, Sinilnikova, OM, Soucy, P, McGuffog, L, Healey, S, Lee, A, Peterlongo, P, Manoukian, S, Peissel, B, Zaffaroni, D, Cattaneo, E, Barile, M, Pensotti, V, Pasini, B, Dolcetti, R, Giannini, G, Laura Putignano, A, Varesco, L, Radice, P, Mai, PL, Greene, MH, Andrulis, IL, Glendon, G, Ozcelik, H, Thomassen, M, Gerdes, A-M, Kruse, TA, Birk Jensen, U, Crüger, DG, Caligo, MA, Laitman, Y, Milgrom, R, Kaufman, B, Paluch-Shimon, S, Friedman, E, Loman, N, Harbst, K, Lindblom, A, Arver, B, Ehrencrona, H, Melin, B, Nathanson, KL, Domchek, SM, Rebbeck, T, Jakubowska, A, Lubinski, J, Gronwald, J, Huzarski, T, Byrski, T, Cybulski, C, Gorski, B, Osorio, A, Ramón y Cajal, T, Fostira, F, Andrés, R, Benitez, J, Hamann, U, Hogervorst, FB, Rookus, MA, Hooning, MJ, Nelen, MR, van der Luijt, RB, van Os, TAM, van Asperen, CJ, Devilee, P, Meijers-Heijboer, HEJ, Gómez Garcia, EB, Peock, S, Cook, M, Frost, D, Platte, R, Leyland, J, Gareth Evans, D, Lalloo, F, Eeles, R, Izatt, L, Adlard, J, Davidson, R, Eccles, D, Ong, K-R, Cook, J, Douglas, F, Paterson, J, John Kennedy, M, Miedzybrodzka, Z, Godwin, A, Stoppa-Lyonnet, D, Buecher, B, Belotti, M, Tirapo, C, Mazoyer, S, Barjhoux, L, Lasset, C, Leroux, D, Faivre, L, Bronner, M, Prieur, F, Nogues, C, Rouleau, E, Pujol, P, Coupier, I, Frénay, M, Hopper, JL, Daly, MB, Terry, MB, John, EM, Buys, SS, Yassin, Y, Miron, A, Goldgar, D, Singer, CF, Tea, M-K, Pfeiler, G, Catharina Dressler, A, Hansen, TVO, Jønson, L, Ejlertsen, B, Bjork Barkardottir, R, Kirchhoff, T, Offit, K, Piedmonte, M, Rodriguez, G, Small, L, Boggess, J, Blank, S, Basil, J, Azodi, M, Ewart Toland, A, Montagna, M, Tognazzo, S, Agata, S, Imyanitov, E, Janavicius, R, Lazaro, C, Blanco, I, Pharoah, PDP, Sucheston, L, Karlan, BY, Walsh, CS, Olah, E, Bozsik, A, Teo, S-H, Seldon, JL, Beattie, MS, van Rensburg, EJ, Sluiter, MD, Diez, O, Schmutzler, RK, Wappenschmidt, B, Engel, C, Meindl, A, Ruehl, I, Varon-Mateeva, R, Kast, K, Deissler, H, Niederacher, D, Arnold, N, Gadzicki, D, Schönbuchner, I, Caldes, T, de la Hoya, M, Nevanlinna, H, Aittomäki, K, Dumont, M, Chiquette, J, Tischkowitz, M, Chen, X, Beesley, J, Spurdle, AB, Neuhausen, SL, Chun Ding, Y, Fredericksen, Z, Wang, X, Pankratz, VS, Couch, F, Simard, J, Easton, DF & Chenevix-Trench, G 2011, 'Common alleles at 6q25.1 and 1p11.2 are associated with breast cancer risk for BRCA1 and BRCA2 mutation carriers', Human Molecular Genetics, vol. 20, no. 16, pp. 3304-3321.
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Ball, P & Pont, L 2011, 'Addressing the gap', Australian Journal of Pharmacy, vol. 92, no. 1096, p. 42.
Ball, P & Pont, L 2011, 'Divided we fail', Australian Journal of Pharmacy, vol. 92, no. 1088, p. 23.
Ball, P & Pont, L 2011, 'Rural solution can lead change', Australian Journal of Pharmacy, vol. 92, no. 1094, p. 43.
Ball, P & Pont, L 2011, 'Time to move on eHealth', Australian Journal of Pharmacy, vol. 92, no. 1098, p. 36.
Banks, E, Jorm, L, Rogers, K, Clements, M & Bauman, A 2011, 'Screen-time, obesity, ageing and disability: findings from 91 266 participants in the 45 and Up Study', Public Health Nutrition, vol. 14, no. 1, pp. 34-43.
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AbstractObjectiveTo assess the relationship between obesity and sedentary behaviours, such as watching television or using a computer (‘screen-time’), and describe how this relationship varies between population subgroups.DesignCross-sectional analysis of the relationship between obesity (BMI ≥ 30 kg/m2) and screen-time, adjusted for age, sex, income and education and compared according to a range of personal characteristics.SettingNew South Wales, Australia.SubjectsA total of 91 266 men and women aged 45 years and above from the general population of New South Wales in 2006–2007 and providing self-reported information on height and weight and other factors.ResultsObesity prevalence was 21·4 %. Compared to individuals with <2 h of daily screen-time, the adjusted relative risks (RR) of obesity were 1·35 (95 % CI 1·26, 1·44), 1·70 (95 % CI 1·59, 1·82), 1·94 (95 % CI 1·81, 2·08) and 1·92 (95 % CI 1·80, 2·06) for 2–3, 4–5, 6–7 and ≥8 h, respectively. The increase in obesity with increasing screen-time was similar within categories of overall physical activity, but was attenuated in those in full-time paid work, compared to non-workers (P for interaction < 0·0001). Among non-workers, the overall obesity RR per 2 h increase in daily screen-time was 1·23 (95 % CI 1·21, 1·25) and was significantly elevated in all groups examined, ranging from 1·16 to 1·31 accordi...
Berle, D, Starcevic, V, Moses, K, Hannan, A, Milicevic, D & Sammut, P 2011, 'Preliminary validation of an ultra‐brief version of the Penn State Worry Questionnaire', Clinical Psychology & Psychotherapy, vol. 18, no. 4, pp. 339-346.
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AbstractThe Penn State Worry Questionnaire (PSWQ) is widely regarded as the gold standard self‐report questionnaire for pathological worry. However, the factorial structure of the scale remains contentious. We sought to determine whether a psychometrically sound brief version of the PSWQ, which avoids contentious items and yet incorporates the essential features of pathological worry, could be derived from the existing PSWQ item pool. After inspecting items of the PSWQ and the findings of previous factor analytic studies, three items were selected that capture the essence of pathological worry (i.e., high frequency, perceived uncontrollability and multiple domains of worry), according to the Diagnostic and Statistical Manual of Mental Disorders (Fourth Edition). We then compared the psychometric properties of the 3‐item PSWQ with the full PSWQ in a sample of 225 clients attending an anxiety disorders clinic. Despite its brevity, the 3‐item PSWQ had internal consistency comparable with that of the standard PSWQ, and performed equally well with regards to convergent and discriminant validity, in screening for a generalized anxiety disorder diagnosis and in detecting change with treatment. The 3‐item ultra‐brief version of the PSWQ is quick to administer, simple to score and possesses psychometric properties very similar to the 16‐item version. Further research should confirm the psychometric properties of the 3‐item version when administered independently of the other items and assess the scale's test–retest reliability. Copyright © 2010 John Wiley & Sons, Ltd.Key Practitioner Message:• The 3‐item version of the Penn State Worry Questionnaire (PSWQ) captures the essence of pathological worry, as defined by the Diagnostic and Statistical Manual of Mental Health Disorders (Fourth Edition).• The 3‐item version of the PSWQ appears to have similar psy...
BIELEMAN, HJ, BIERMA-ZEINSTRA, SMA, OOSTERVELD, FGJ, RENEMAN, MF, VERHAGEN, AP & GROOTHOFF, JW 2011, 'The Effect of Osteoarthritis of the Hip or Knee on Work Participation', The Journal of Rheumatology, vol. 38, no. 9, pp. 1835-1843.
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In our systematic literature search, we included studies involving patients with hip or knee osteoarthritis (OA) and outcome measures of work participation. Methodological quality was assessed using 11 criteria; a qualitative data analysis was performed. Fifty-three full-text articles were selected out of 1861 abstracts; finally, data were extracted from 14 articles. Design, populations, definitions, and measurements in the studies showed large variations; work outcomes were often only secondary objectives. The outcomes were summarized as showing a mild negative effect of OA on work participation. Many patients had paid work and managed to stay at work despite limitations. However, research on the effect of OA on work participation is scarce and the methodological quality is often insufficient. The longitudinal course of work participation in individuals with OA has not been described completely.
Bierma-Zeinstra, SMA & Verhagen, AP 2011, 'Osteoarthritis subpopulations and implications for clinical trial design', Arthritis Research & Therapy, vol. 13, no. 2, pp. 213-213.
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Blake, HL, Hewat, S & Spencer, E 2011, 'Native Speaker and Non-Native Speaker Communication During Job Interviews', Asia Pacific Journal of Speech, Language and Hearing, vol. 14, no. 3, pp. 171-178.
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Brakoulias, V, Starcevic, V, Sammut, P, Berle, D, Milicevic, D, Moses, K & Hannan, A 2011, 'Obsessive-Compulsive Spectrum Disorders: a Comorbidity and Family History Perspective', Australasian Psychiatry, vol. 19, no. 2, pp. 151-155.
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Objective: The concept of obsessive-compulsive spectrum disorders (OCSDs) has become so influential that there are proposals to introduce it into new diagnostic classificatory systems. The aim of this paper was to assess whether rates of comorbidity and family history of OCSDs in patients with obsessive-compulsive disorder (OCD) supported this concept. Method: Comorbidity and family history were assessed in a group of participants with a primary diagnosis of OCD, using structured clinical interviews. Rates of OCSDs and other anxiety disorders (OADs), excluding OCD, were compared. Results: Of the 77 OCD participants assessed, the most prevalent comorbid conditions were OADs: generalized anxiety disorder (34.6%), specific phobia (26.9%), social phobia (21.8%) and panic disorder (19.2%). The proposed OCSDs were less frequently comorbid: tic disorder (12.8%), trichotillomania (5.1%), hypochondriasis (3.8%) and body dysmorphic disorder (BDD) (3.8%). Similar trends were observed for a family history of these disorders. No participant reported a family history of an OCSD without a family history of an OAD. Conclusions: Although the concept of OCSDs has invigorated thinking in this complex diagnostic field, these results support the current association of OCD with OADs rather than with OCSDs.
Bridgman, K, Onslow, M, O'Brian, S & Block, S 2011, 'Changes to Stuttering Measurement During the Lidcombe Program Treatment Process', Asia Pacific Journal of Speech, Language and Hearing, vol. 14, no. 3, pp. 147-152.
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Carr Swift, M, O'Brian, S, Hewat, S, Onslow, M, Packman, A & Menzies, R 2011, 'Investigating parent delivery of the Lidcombe Program', International Journal of Speech-Language Pathology, vol. 13, no. 4, pp. 308-316.
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The Lidcombe Program is an early childhood stuttering treatment delivered by parents in the child's everyday environment, under the guidance of a speech-language pathologist (SLP). Given the parents' central role in the treatment delivery, the way it is implemented away from the clinic and away from the SLP's input is very important. And yet, to date there has been very little investigation into this process. This study investigated to what extent parents deliver contingencies for stuttering and stutter-free speech, in structured and unstructured conversations, as directed in the treatment manual. Participants were three mothers and their children who were receiving the Lidcombe Program. They recorded two treatment sessions each week and completed a daily treatment diary. The recordings were analysed for the use of parent verbal contingencies (PVCs). This method detected differences in PVC delivery by the mothers both across and within cases over time. The results show that valuable information can be gained from analysing home treatment sessions in this way and with a few modifications this methodology would be useful in larger scale studies. The strengths and limitations of this methodology are discussed with future larger studies of this type recommended. © 2011 The Speech Pathology Association of Australia Limited.
Chaar, BB, Brien, JA, Hanrahan, J, McLachlan, A, Penm, J & Pont, L 2011, 'Experimental education in Australian pharmacy: Preceptors' perspectives', Pharmacy Education, vol. 11, no. 1, pp. 166-171.
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Background: Experiential education is key to students understanding their future practice settings. The quality and success of experiential education rest largely on volunteer preceptors, who are an essential asset to the education of pharmacy students in Australia. This asset needs constant support and nurturing. Aims: This study aims to explore the perceptions of Australian preceptors' and their needs regarding their role in training future generations of pharmacists. Method: Five focus groups of pharmacist preceptors were conducted, audio-taped and transcribed verbatim. Transcripts were thematically analysed to identify major themes related to pharmacy experiential education. Results: Thirty seven pharmacists participated in the focus group interviews, representing diverse demographics and workplace settings. Pharmacists reported enjoying the role of preceptor however, lack of insight into education techniques, increased workload, lack of time and space, and increased stress levels were identified by participants as obstacles to achieving good educational outcomes. Conclusion: Preceptors are role models for novice practitioners, and the relationships between universities and preceptors need to be robust, supportive and relevant to changing professional and health sector environments. © 2011 FIP.
Cox, DG, Simard, J, Sinnett, D, Hamdi, Y, Soucy, P, Ouimet, M, Barjhoux, L, Verny-Pierre, C, McGuffog, L, Healey, S, Szabo, C, Greene, MH, Mai, PL, Andrulis, IL, Thomassen, M, Gerdes, A-M, Caligo, MA, Friedman, E, Laitman, Y, Kaufman, B, Paluch, SS, Borg, Å, Karlsson, P, Stenmark Askmalm, M, Barbany Bustinza, G, Nathanson, KL, Domchek, SM, Rebbeck, TR, Benítez, J, Hamann, U, Rookus, MA, van den Ouweland, AMW, Ausems, MGEM, Aalfs, CM, van Asperen, CJ, Devilee, P, Gille, HJJP, Peock, S, Frost, D, Evans, DG, Eeles, R, Izatt, L, Adlard, J, Paterson, J, Eason, J, Godwin, AK, Remon, M-A, Moncoutier, V, Gauthier-Villars, M, Lasset, C, Giraud, S, Hardouin, A, Berthet, P, Sobol, H, Eisinger, F, Bressac de Paillerets, B, Caron, O, Delnatte, C, Goldgar, D, Miron, A, Ozcelik, H, Buys, S, Southey, MC, Terry, MB, Singer, CF, Dressler, A-C, Tea, M-K, Hansen, TVO, Johannsson, O, Piedmonte, M, Rodriguez, GC, Basil, JB, Blank, S, Toland, AE, Montagna, M, Isaacs, C, Blanco, I, Gayther, SA, Moysich, KB, Schmutzler, RK, Wappenschmidt, B, Engel, C, Meindl, A, Ditsch, N, Arnold, N, Niederacher, D, Sutter, C, Gadzicki, D, Fiebig, B, Caldes, T, Laframboise, R, Nevanlinna, H, Chen, X, Beesley, J, Spurdle, AB, Neuhausen, SL, Ding, YC, Couch, FJ, Wang, X, Peterlongo, P, Manoukian, S, Bernard, L, Radice, P, Easton, DF, Chenevix-Trench, G, Antoniou, AC, Stoppa-Lyonnet, D, Mazoyer, S, Sinilnikova, OM, Dumont, M, Mai, PL, Greene, MH, Glendon, G, Selander, T, Weerasooriya, N, Karlsson, P, Nordling, M, Bergman, A, Einbeigi, Z, Stenmark-Askmalm, M, Liedgren, S, Borg, Å, Loman, N, Olsson, H, Kristoffersson, U, Soller, M, Jernström, H, Harbst, K, Henriksson, K, Lindblom, A, Arver, B, von Wachenfeldt, A, Liljegren, A, Barbany-Bustinza, G, Rantala, J, Melin, B, Grönberg, H, Stattin, E-L, Emanuelsson, M, Ehrencrona, H, Torres, D, Rashid, MU, Seidel-Renkert, A, Hogervorst, FBL, Verhoef, S, Verheus, M, van't Veer, LJ, van Leeuwen, FE, Rookus, MA, Collée, M, van den Ouweland, AMW, Jager, A, Hooning, MJ, Tilanus-Linthorst, MMA, Seynaeve, C, van Asperen, CJ, Wijnen, JT, Vreeswijk, MP, Tollenaar, RA, Devilee, P, Ligtenberg, MJ, Hoogerbrugge, N, Ausems, MG, van der Luijt, RB, Aalfs, CM, van Os, TA, Gille, JJP, Waisfisz, Q, Meijers-Heijboer, HEJ, Gomez-Garcia, EB, van Roozendaal, CE, Blok, MJ, Caanen, B, Oosterwijk, JC, van der Hout, AH, Mourits, MJ & et al. 2011, 'Common variants of the BRCA1 wild-type allele modify the risk of breast cancer in BRCA1 mutation carriers', Human Molecular Genetics, vol. 20, no. 23, pp. 4732-4747.
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Dancyger, C, Wiseman, M, Jacobs, C, Smith, JA, Wallace, M & Michie, S 2011, 'Communicating BRCA1/2 genetic test results within the family: A qualitative analysis', Psychology & Health, vol. 26, no. 8, pp. 1018-1035.
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de Groot, FM, Voogt-Bode, A, Passchier, J, Berger, MY, Koes, BW & Verhagen, AP 2011, 'Headache: the Placebo Effects in the Control Groups in Randomized Clinical Trials; an Analysis of Systematic Reviews', Journal of Manipulative and Physiological Therapeutics, vol. 34, no. 5, pp. 297-305.
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De Morgan, S, Redman, S, D’Este, C & Rogers, K 2011, 'Knowledge, satisfaction with information, decisional conflict and psychological morbidity amongst women diagnosed with ductal carcinoma in situ (DCIS)', Patient Education and Counseling, vol. 84, no. 1, pp. 62-68.
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Objective: To assess knowledge, satisfaction with information, decisional conflict and psychological morbidity amongst women diagnosed with ductal carcinoma in situ (DCIS) and to explore the factors associated with less knowledge and greater confusion about DCIS. Methods: A cross-sectional survey of women diagnosed with DCIS in Australia (N=144). Results: This study found misunderstanding and confusion amongst women diagnosed with DCIS and a desire for more information about their breast disease. Approximately half of participants worried about their breast disease metastasizing; approximately half expressed high decisional conflict; 12% were anxious and 2% were depressed. Logistic regression analysis demonstrated that worry about dying from the breast disease was significantly associated with not knowing that DCIS could not metastasize (OR 3.9; 95% CI 1.03-14.25); and confusion about whether DCIS could metastasize was significantly associated with dissatisfaction with information (OR 12.5; 95% CI 3.8-40.2). Conclusion: Good communication about how DCIS differs from invasive breast cancer is essential to alleviating the confusion and worry amongst women with DCIS. Practice implications: Recommendations about how best to communicate a diagnosis of DCIS, including the uncertainties, are needed to guide health professionals to promote better understanding about DCIS and increase the well-being of women with DCIS. © 2010.
DYET, KH, ROBERTSON, I, TURBITT, E & CARTER, PE 2011, 'Characterization ofEscherichia coliO157:H7 in New Zealand using multiple-locus variable-number tandem-repeat analysis', Epidemiology and Infection, vol. 139, no. 3, pp. 464-471.
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SUMMARYRecently, multiple-locus variable-number tandem-repeat analysis (MLVA) has been proposed as an alternative to pulsed-field gel electrophoresis (PFGE) for characterization ofEscherichia coliO157:H7. In this study we characterized 118E. coliO157:H7 isolates from cases of gastrointestinal disease in New Zealand usingXbaI PFGE profiles and a MLVA scheme that assessed variability in eight polymorphic loci. The 118 isolates characterized included all 80E. coliO157:H7 referred to New Zealand's Enteric Reference Laboratory in 2006 and 29 phage-type 2 isolates from 2005. When applied to these isolates the discriminatory power of PFGE and MLVA was not significantly different. However, MLVA data may be more epidemiologically relevant as isolates from family clusters of disease had identical MLVA profiles, even when theXbaI PFGE profiles differed slightly. Furthermore, most isolates with indistinguishableXbaI PFGE profiles that did not appear to be epidemiologically related had distinct MLVA profiles.
DYET, KH, TURBITT, E & CARTER, PE 2011, 'Multiple-locus variable-number tandem-repeat analysis for discriminating withinSalmonella entericaserovar Typhimurium definitive types and investigation of outbreaks', Epidemiology and Infection, vol. 139, no. 7, pp. 1050-1059.
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SUMMARYThe discriminatory power of multiple-locus variable-number tandem-repeat analysis (MLVA) needs to be evaluated for allSalmonella entericasubspeciesentericaserovar Typhimurium (S. Typhimurium) phage types so that the power of this methodology is understood and results can be interpreted correctly during outbreak investigations. We evaluated the ability of MLVA to characterize four definitive phage types (DT) problematic in New Zealand. MLVA discriminated between DT104 isolates although there was very limited variation in the MLVA profiles for isolates with an RDNC phage type (reacts but does not conform to a recognized Typhimurium phage pattern) first observed in New Zealand's Enteric Reference Laboratory in May 2006. Most DT101 isolates had indistinguishable MLVA profiles or profiles that differed at one or two loci. This was also observed in DT160 isolates. MLVA may not identify all common-source outbreaks although it provided valuable data when applied to case isolates from twoS. Typhimurium outbreaks.
Einstein, DA, Menzies, RG, St Clare, T, Drobny, J & Helgadottir, FD 2011, 'The treatment of magical ideation in two individuals with obsessive compulsive disorder', The Cognitive Behaviour Therapist, vol. 4, no. 1, pp. 16-29.
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AbstractData collected from clinical populations indicate that magical ideation (MI) may play a causal or a mediating role in the expression of obsessive compulsive symptoms. If this is the case then when targeted in treatment, symptoms of obsessive compulsive disorder (OCD) should be altered. Two individuals diagnosed with OCD received a trial treatment targeting magical thinking. The intervention consisted of a series of procedures designed to undermine superstitious/MI without targeting obsessions or compulsions. The procedures involved critical analysis of the following material: (1) a free astrology offer; (2) a horoscope prediction exercise; (3) a description of four different cultural explanations of the origin of fire; (4) an instructive guide for Tarot card readers; (5) a report of a UFO sighting; (6) a video-clip describing a cult festival; (7) a description of a ‘hoax’ channeler and (8) a superstition exercise. Measures of obsessive compulsive symptoms, superstition, MI and thought–action fusion were administered pre-treatment, post-treatment and at 3 months’ follow-up. According to the twofold criterion of Jacobson et al. (Behaviour Therapy 1984, 15, 336–352), following treatment the patients were identified as being recovered on measures of magical and superstitious thinking and on the Padua Inventory.
Firth, C, Jacobs, C, Evison, M, Pichert, G, Izatt, L & Hunter, MS 2011, 'Novel one‐stop multidisciplinary follow‐up clinic for BRCA1/2 carriers: patient satisfaction and decision making', Psycho-Oncology, vol. 20, no. 12, pp. 1301-1308.
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AbstractObjective: To evaluate patient' satisfaction and cancer risk management decision making, following attendance at a novel multidisciplinary one‐stop follow‐up clinic (MDOSC) for BRCA1/2 carriers.Patients and Methods: 172 patients attended the MDOSC over a 2‐year period between 2006 and 2008. A total of 96 and 76 patients were seen in the first and second year, respectively. All patients who attended the MDOSC were sent a 17‐item Satisfaction Questionnaire (SQ) designed to examine their views about the MDOSC, using rating scales and open questions after the first year. Patients were asked to comment on the most helpful aspects of the MDOSC and on how the service might be improved. Changes were made based on this feedback. During the second year, all patients were given the SQ with three questions about cancer risk management decision making on the day of the MDOSC.Results: In total, 132 (77%) patients responded and overall satisfaction was high with a mean of 8.94 (range 1–10). BRCA1/2 carriers were pleased to see a range of health care professionals on the same day, who they viewed gave consistent information, considered every aspect of care and addressed psychosocial needs. Following improvements, based on patients' feedback, satisfaction significantly increased in year 2. Furthermore, the MDOSC also helped patients to move forward with their cancer risk management decisions.Conclusions: BRCA1/2 carriers were highly satisfied with the MDOSC, which met their needs and helped them to make informed decisions regarding their cancer risk management. Copyright © 2010 John Wiley & Sons, Ltd.
Freeman-Sanderson, A, Togher, L, Phipps, P & Elkins, M 2011, 'A clinical audit of the management of patients with a tracheostomy in an Australian tertiary hospital intensive care unit: Focus on speech-language pathology', International Journal of Speech-Language Pathology, vol. 13, no. 6, pp. 518-525.
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Golzan, SM, Avolio, A & Graham, SL 2011, 'Minimising retinal vessel artefacts in optical coherence tomography images', Computer Methods and Programs in Biomedicine, vol. 104, no. 2, pp. 206-211.
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Golzan, SM, Graham, SL, Leaney, J & Avolio, A 2011, 'Dynamic Association between Intraocular Pressure and Spontaneous Pulsations of Retinal Veins', Current Eye Research, vol. 36, no. 1, pp. 53-59.
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Gu, P, Williams, KA, Aslani, P & Chaar, BB 2011, 'Direct–to–Consumer Advertising of Prescription Medicines on the Internet: An Australian Consumer Perspective', Journal of Pharmacy Practice and Research, vol. 41, no. 3, pp. 196-202.
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ABSTRACTBackgroundIn Australia there are strict regulations in place to protect the consumer from direct–to–consumer advertising (DTCA) of prescription medicines. However, the degree of infallibility of these restrictions is unclear.AimTo investigate the DTCA encountered by Australian consumers when searching the Internet for common health‐ or medicine‐related questions.Method2 health topics, weight loss and impotence, were chosen and explored from 2 perspectives – the health condition and a commonly used medicine (brand name). Key words were chosen to simulate the language and search style of a consumer. The first 10 hits from each search were evaluated using the validated DISCERN scale, and a descriptive report of each web site was conducted with a specific focus on evidence for DTCA.ResultsOf the 70 web sites visited, 10 sites originating from the USA or New Zealand exhibited DTCA. The scale and intensity of DTCA varied between search topics and strategies and ranged in appearance from simple, pictorial advertising to subtle forms of persuasive language. DTCA of some pharmaceuticals was often hidden within disease awareness campaigns, ePharmacy web pages and online communities.ConclusionAustralian consumers are exposed to DTCA of prescription medicines on the Internet. Clearly, DTCA restrictions in Australia are not infallible. Australian policy makers in the interests of public health must take measures to address the gaps.
Hämmerlein, A, Müller, U & Schulz, M 2011, 'Pharmacist‐led intervention study to improve inhalation technique in asthma and COPD patients', Journal of Evaluation in Clinical Practice, vol. 17, no. 1, pp. 61-70.
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AbstractRational and aims Inhaled therapy is the mainstay of treatment in patients with asthma and chronic obstructive pulmonary disease (COPD). For effectiveness of pharmacotherapy, correct use of medication is required. The aims of this study were to survey the quality of inhalation technique in patients and to determine the effect of a single intervention in community pharmacies by means of standardized procedures.Methods A total of 757 patients with asthma or COPD were randomly selected by 55 community pharmacies. At baseline, patients were interviewed and their inhalation technique was assessed with a 21‐items checklist. Any error was recorded and, if necessary, patients were instructed in the proper use of their device. After 4–6 weeks, demonstration of inhalation technique was repeated in the community pharmacies and a pre–post comparison was performed.Results A total of 597 patients (78.9%) made at least one mistake in performing the inhalation technique at baseline. This number dropped to 214 (28.3%) from the first to the second appointment. All patients did benefit from the pharmacists' intervention regardless of their former training experiences.Conclusions Inhalation technique of asthma and COPD patients is poor. In daily practice, community pharmacy‐based pharmacists are well suited to significantly supplement doctor‐based education in inhalation technique.
Hemsley, B, Balandin, S & Togher, L 2011, 'Caregivers of Adults with Developmental Disabilities'.
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Hemsley, B, Balandin, S & Worrall, L 2011, 'Nursing the Patient With Developmental Disability in Hospital', Qualitative Health Research, vol. 21, no. 12, pp. 1632-1642.
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Our aim in this narrative inquiry was to understand the roles of paid carers supporting adults with developmental disability and complex communication needs in hospital, from the perspectives of 15 paid carers, 15 adults with developmental disability, and 15 hospital nurses. Results demonstrated that paid carers have an important role in supporting the adult with disability, providing information, delivering basic care, and facilitating communication. Stories reflected paid carer volunteerism; lack of orientation of carers and hospital staff to the paid carers’ roles; blurred role boundaries between paid carers, family carers, and nurses; and paid carers being uncertain about their own responsibilities for staff and patient safety. New policies and practice guidelines are needed to guide both health and disability services in clarifying paid carer roles and role boundaries, and to enable paid carers and hospital staff to work together effectively on the ward in the care of adults with developmental disability.
Hemsley, B, Balandin, S & Worrall, L 2011, 'The “Big 5” and beyond: Nurses, paid carers, and adults with developmental disability discuss communication needs in hospital', Applied Nursing Research, vol. 24, no. 4, pp. e51-e58.
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Adults with developmental disability and little or no speech need to communicate with nurses in hospital to (a) express physical needs, (b) discuss health, (c) convey intelligence and emotions, (d) connect socially, and (e) control the environment. All stakeholders need access to a variety of communication strategies to support communication of these needs. © 2011.
Hodge, C, Lawless, M & Sutton, G 2011, 'Keratectasia following LASIK in a patient with uncomplicated PRK in the fellow eye', Journal of Cataract and Refractive Surgery, vol. 37, no. 3, pp. 603-607.
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We present a case of unilateral keratectasia in a laser refractive surgery patient. Laser in situ keratomileusis (LASIK) was performed in the first eye, but because of difficulty lifting the femtosecond-created cap in the second eye, photorefractive keratectomy was performed in that eye. Neither eye had risk factors for keratectasia; both had identical low scores on the Randleman risk factor score. Although femtosecond laser caps were created in both eyes, ectasia developed in only the LASIK eye, in which the cap was lifted. We believe this is the first case of this complication reported in the literature. It highlights our incomplete knowledge of the risk factors for keratectasia following LASIK and suggests that unlifted flaps do not undergo the same biomechanical weakening as flaps that are lifted. © 2011 ASCRS and ESCRS.
Hodge, C, Sutton, G, Lawless, M & Rogers, C 2011, 'Photorefractive keratectomy with mitomycin-C after corneal transplantation for keratoconus', Journal of Cataract and Refractive Surgery, vol. 37, no. 10, pp. 1884-1894.
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Purpose: To evaluate the efficacy of photorefractive keratectomy (PRK) for residual refractive error after penetrating keratoplasty (PKP) for keratoconus. Setting: Private ophthalmic clinic. Design: Case series. Method: Consecutive patients who had PRK augmented with topical mitomycin-C (MMC) after PKP for keratoconus were retrospectively reviewed. Patients were divided into a a low cylinder group (refractive cylinder ≤6.00 D) and a high cylinder group (refractive cylinder >6.00 D). Visual acuity, refraction, and keratometry were analyzed preoperatively and 1, 3, 6, and 12 months postoperatively. Results: The study comprised 47 eyes (41 patients). The spherical equivalent (SE) decreased from -4.24 D ± 3.23 (SD) preoperatively to -0.71 ± 1.03 D 12 months postoperatively in the low cylinder group and from -4.19 ± 3.54 D to -2.45 ± 3.42 D, respectively, in the high cylinder group. The refractive cylinder decreased from -4.27 ± 1.4 D to -1.71 ± 1.55 D, respectively, in the low cylinder group and from -7.78 ± 1.21 D to -4.6 ± 2.54 D, respectively, in the high cylinder group. By the last follow-up, 8.3% of patients had lost 2 lines of corrected distance visual acuity. There were no cases of corneal haze greater than 2+ or of graft rejection. Conclusions: Penetrating keratoplasty with adjunctive MMC decreased several refractive variables in patients with previous PKP. These results compare well with those in the published literature and suggest PRK is as effective as, and probably safer than, laser in situ keratomileusis in treating refractive error in these cases. Financial Disclosure: No author has financial or proprietary interests in any material or method mentioned. © 2011 ASCRS and ESCRS.
Hush, JM, Lin, CC, Michaleff, ZA, Verhagen, A & Refshauge, KM 2011, 'Prognosis of Acute Idiopathic Neck Pain is Poor: A Systematic Review and Meta-Analysis', Archives of Physical Medicine and Rehabilitation, vol. 92, no. 5, pp. 824-829.
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Iverach, L, Jones, M, Menzies, RG, O’Brian, S, Packman, A & Onslow, M 2011, 'Response to Walter Manning and J. Gayle Beck: Comments concerning Iverach, Jones et al. (2009a)', Journal of Fluency Disorders, vol. 36, no. 1, pp. 66-71.
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Iverach, L, Menzies, R, Jones, M, O'Brian, S, Packman, A & Onslow, M 2011, 'Further development and validation of the Unhelpful Thoughts and Beliefs About Stuttering (UTBAS) scales: relationship to anxiety and social phobia among adults who stutter', International Journal of Language & Communication Disorders, vol. 46, no. 3, pp. 286-299.
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Abstract Background: In an initial validation study, the Unhelpful Thoughts and Beliefs About Stuttering (UTBAS I) scale, demonstrated excellent psychometric properties as a self‐report measure of the frequency of unhelpful cognitions associated with social anxiety for adults who stutter. Aims: The aim was to further validate the original UTBAS I scale, and to develop two additional scales to assess beliefs (UTBAS II) and anxiety (UTBAS III) associated with negative thoughts. Methods & Procedures: A total of 140 adults seeking speech‐restructuring treatment for stuttering completed the original UTBAS I scale, the newly developed UTBAS II and III scales, and self‐report measures of psychological functioning. Participants also completed a first‐stage screener for the presence of anxious personality disorder, and a diagnostic assessment to evaluate the presence of social phobia, according to criteria of the Diagnostic and Statistical Manual of Mental Disorders (DSM‐IV) and the International Classification of Diseases (ICD‐10). Outcomes & Results: The mean UTBAS I score for the present sample did not differ significantly from the mean score reported in the original UTBAS I validation study. Convergent validity was confirmed by significant correlations between the UTBAS Total score and all anxiety‐related measures. Discriminant validity was established by the absence of strong correlations between the UTBAS Total score and some of the self‐report measures of unrelated constructs, although it was found to tap into the negative cognitions associated with depression and life problems. Approximately one‐quarter of participants met criteria for a diagnosis of DSM‐IV or ICD‐10 social phobia (23.5% and 27.2% respectively), and nearly one‐third met first‐stage screening...
Iverach, L, Menzies, RG, O’Brian, S, Packman, A & Onslow, M 2011, 'Anxiety and Stuttering: Continuing to Explore a Complex Relationship', American Journal of Speech-Language Pathology, vol. 20, no. 3, pp. 221-232.
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PurposeThe relationship between anxiety and stuttering has been widely studied. However, a review conducted more than 10 years ago (Menzies, Onslow, & Packman, 1999) identified 5 methodological issues thought to preclude consistent research findings regarding the nature of this relationship. The purpose of the present review was to determine whether methodological improvements have occurred since the Menzies et al. (1999) review.MethodLiterature published since the Menzies et al. review was evaluated with regard to the 5 methodological issues identified in that review: (a) the construct of anxiety, (b) trait anxiety measures, (c) participant numbers, (d) treatment status of participants, and (e) speaking tasks.ResultsDespite some remaining ambiguous findings, research published since the Menzies et al. review has provided far stronger evidence of a relationship between stuttering and anxiety, and has focused more on social anxiety, expectancies of social harm, and fear of negative evaluation.ConclusionThe aims of future research should be to improve research design, increase statistical power, employ multidimensional measures of anxiety, and further develop anxiolytic treatment options for people who stutter.
Jacobs, WCH, van Tulder, M, Arts, M, Rubinstein, SM, van Middelkoop, M, Ostelo, R, Verhagen, A, Koes, B & Peul, WC 2011, 'Surgery versus conservative management of sciatica due to a lumbar herniated disc: a systematic review', European Spine Journal, vol. 20, no. 4, pp. 513-522.
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Jones, M, Dobson, A & O’Brian, S 2011, 'A graphical method for assessing agreement with the mean between multiple observers using continuous measures', International Journal of Epidemiology, vol. 40, no. 5, pp. 1308-1313.
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Background: Currently, we are not aware of a method to assess graphically on one simple plot agreement between more than two observers making continuous measurements on the same subjects. Methods: We aimed to develop a simple graphical method to assess agreement between multiple observers using continuous measurements. The Bland-Altman graphical method for assessing agreement between two observers using continuous measures was modified and extended to accommodate multiple observers. Mathematical formulae are derived and real data examples used to illustrate the proposed method. Results: The examples show that the proposed graphical method of assessing agreement provides clinically useful information. This information includes estimates of the limits of agreement with the mean and a visual means for determining these limits over the range of measurements. In a data example that included five readers' measurements of 40 lung lesions, the intra-class correlation (ICC) was 0.84 indicating readers can reliably measure the lesions. However, the estimated limits of agreement with the mean were -1.1 to 1.1 cm implying that the readers' measurements can plausibly differ from the mean estimated tumour size by more than 1 cm. This is a clinically significant difference according to the study authors. In addition, a plot of the limits of agreement with the mean by mean tumour size shows heterogeneous agreement presumably due to the varying degrees of definition at the edge of the lesions. Conclusions The proposed graphical method of assessing agreement can be used alongside other measures such as ICC for reporting on reproducibility in studies of multiple observers making continuous measurements. © The Author 2011; all rights reserved.
Kelly, F, Sare, AT, Williams, KA & Benrimoj, SI 2011, 'Non-prescription medicine supply: protocols and practice', International Journal of Pharmacy Practice, vol. 10, no. Supplement_1, pp. R72-R72.
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Abstract Focal points
Koenig-Robert, R & VanRullen, R 2011, 'Spatiotemporal mapping of visual attention', Journal of Vision, vol. 11, no. 14, pp. 12-12.
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Koushik, S, Hewat, S, Shenker, RC, Jones, M & Onslow, M 2011, 'North-American Lidcombe Program file audit: Replication and meta-analysis', International Journal of Speech-Language Pathology, vol. 13, no. 4, pp. 301-307.
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Thousands of North American clinicians have trained for the Lidcombe Program of Early Stuttering Intervention, yet there are no benchmark data for that continent. This retrospective file audit includes logistical regression of variables from files of 134 children younger than 6 years who completed Stage 1 of the Lidcombe Program. Benchmarking data for clinic visits to Stage 2 is available for these files. Meta-analysis supplements worldwide Lidcombe Program benchmark data. The median number of clinic visits to Stage 2 was 11. High pre-treatment stuttering severity predicted more clinic visits than low severity. A trend toward statistical significance was found for the frequency of clinic visits. Frequent attendance of mean less than 11 days was associated with longer treatment times than infrequent attendance of mean 11 days or more. Results for North America were consistent with benchmark data from the UK and Australia. The mean attendance trend is clinically important and requires further investigation because of its potential clinical significance. © 2011 The Speech Pathology Association of Australia Limited.
Kuijpers, T, van Middelkoop, M, Rubinstein, SM, Ostelo, R, Verhagen, A, Koes, BW & van Tulder, MW 2011, 'A systematic review on the effectiveness of pharmacological interventions for chronic non-specific low-back pain', European Spine Journal, vol. 20, no. 1, pp. 40-50.
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Laufs, U, Böhm, M, Kroemer, H, Schüssel, K, Griese, N & Schulz, M 2011, 'Strategien zur Verbesserung der Einnahmetreue von Medikamenten', DMW - Deutsche Medizinische Wochenschrift, vol. 136, no. 31/32, pp. 1616-1621.
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Logghe, IHJ, Verhagen, AP, Rademaker, ACHJ, Zeeuwe, PEM, Bierma-Zeinstra, SMA, Van Rossum, E, Faber, MJ, Van Haastregt, JCM & Koes, BW 2011, 'Explaining the ineffectiveness of a Tai Chi fall prevention training for community-living older people: A process evaluation alongside a randomized clinical trial (RCT)', Archives of Gerontology and Geriatrics, vol. 52, no. 3, pp. 357-362.
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Lopes, AD, Costa, LOP, Saragiotto, BT, Yamato, TP, Adami, F & Verhagen, E 2011, 'Musculoskeletal pain is prevalent among recreational runners who are about to compete: an observational study of 1049 runners', Journal of Physiotherapy, vol. 57, no. 3, pp. 179-182.
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McGurk, R, Kneebone, II & Pit ten Cate, IM 2011, '“Sometimes we get it wrong but we keep on trying”: A cross-sectional study of coping with communication problems by informal carers of stroke survivors with aphasia', Aphasiology, vol. 25, no. 12, pp. 1507-1522.
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Background: The need to support carers of stroke survivors is widely recognised. However, research on which to base recommendations is scarce. Little research has focused on carers of stroke survivors with aphasia, and that which exists suffers from problems with sample size and methodology. More information is needed about methods used by carers to manage communication difficulties and about coping strategies that promote emotional wellbeing. Aims: To assess the coping strategies used by informal carers of stroke survivors with aphasia to manage communication problems, and their association with depressive symptoms. To assess whether a problem-specific coping inventory offers an advantage over a generic coping questionnaire for this purpose. Methods & Procedures: Questionnaires were completed by 150 informal caregivers of stroke survivors with aphasia. The Centre for Epidemiologic Studies Depression Scale measured depressive symptoms. Coping was assessed with the Brief COPE and a problem-specific questionnaire on coping with communication difficulties. Level of social support was also assessed. Multiple regression analysis explored associations between coping and depressive symptoms. Mediation analysis assessed the significance of the indirect effect of coping between the level of communication impairment in the stroke survivor and the degree of depressive symptoms in the carer. Outcomes & Results: Participants reported a wide range of coping strategies. Avoidant styles of coping were associated with increased depressive symptomatology. Coping by use of positive reframing was linked with fewer symptoms of depression. Anticipated level of social support was also associated with less depressive symptomology. The level of communication impairment of the stroke survivor was not predictive of depressive symptoms in carers after controlling for coping and social support. Limited support was found for a mediating model of coping. Inclusion of one subscale fro...
Mehta, P 2011, 'Effectiveness of Multiple Plane Relaxed Passive Movements given along with Conventional Treatment in Cervical Spondylosis', Indian journal of physiotherapy and occupational therapy.
Metten, C, Bosshardt, H-G, Jones, M, Eisenhuth, J, Block, S, Carey, B, O'brian, S, Packman, A, Onslow, M & Menzies, R 2011, 'Dual tasking and stuttering: from the laboratory to the clinic', Disability and Rehabilitation, vol. 33, no. 11, pp. 933-944.
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Purpose: The aim of the three studies in this article was to develop a way to include dual tasking in speech restructuring treatment for persons who stutter (PWS). It is thought that this may help clients maintain the benefits of treatment in the real world, where attentional resources are frequently diverted away from controlling fluency by the demands of other tasks. Method. In Part 1, 17 PWS performed a story-telling task and a computer semantic task simultaneously. Part 2 reports the incorporation of the Part 1 protocol into a handy device for use in a clinical setting (the Dual Task and Stuttering Device, DAS-D). Part 3 is a proof of concept study in which three PWS reported on their experiences of using the device during treatment. Results. In Part 1, stuttering frequency and errors on the computer task both increased under dual task conditions, indicating that the protocol would be appropriate for use in a clinical setting. All three participants in Part 3 reported positively on their experiences using the DAS-D. Conclusions. Dual tasking during treatment using the DAS-D appears to be a viable clinical procedure. Further research is required to establish effectiveness. © 2011 Informa UK, Ltd.
Mulligan, AM, Couch, FJ, Barrowdale, D, Domchek, SM, Eccles, D, Nevanlinna, H, Ramus, SJ, Robson, M, Sherman, M, Spurdle, AB, Wappenschmidt, B, Lee, A, McGuffog, L, Healey, S, Sinilnikova, OM, Janavicius, R, Hansen, TV, Nielsen, FC, Ejlertsen, B, Osorio, A, Muñoz-Repeto, I, Durán, M, Godino, J, Pertesi, M, Benítez, J, Peterlongo, P, Manoukian, S, Peissel, B, Zaffaroni, D, Cattaneo, E, Bonanni, B, Viel, A, Pasini, B, Papi, L, Ottini, L, Savarese, A, Bernard, L, Radice, P, Hamann, U, Verheus, M, Meijers-Heijboer, HEJ, Wijnen, J, Gómez García, EB, Nelen, MR, Kets, CM, Seynaeve, C, Tilanus-Linthorst, MMA, van der Luijt, RB, Os, TV, Rookus, M, Frost, D, Jones, JL, Evans, DG, Lalloo, F, Eeles, R, Izatt, L, Adlard, J, Davidson, R, Cook, J, Donaldson, A, Dorkins, H, Gregory, H, Eason, J, Houghton, C, Barwell, J, Side, LE, McCann, E, Murray, A, Peock, S, Godwin, AK, Schmutzler, RK, Rhiem, K, Engel, C, Meindl, A, Ruehl, I, Arnold, N, Niederacher, D, Sutter, C, Deissler, H, Gadzicki, D, Kast, K, Preisler-Adams, S, Varon-Mateeva, R, Schoenbuchner, I, Fiebig, B, Heinritz, W, Schäfer, D, Gevensleben, H, Caux-Moncoutier, V, Fassy-Colcombet, M, Cornelis, F, Mazoyer, S, Léoné, M, Boutry-Kryza, N, Hardouin, A, Berthet, P, Muller, D, Fricker, J-P, Mortemousque, I, Pujol, P, Coupier, I, Lebrun, M, Kientz, C, Longy, M, Sevenet, N, Stoppa-Lyonnet, D, Isaacs, C, Caldes, T, de la Hoya, M, Heikkinen, T, Aittomäki, K, Blanco, I, Lazaro, C, Barkardottir, RB, Soucy, P, Dumont, M, Simard, J, Montagna, M, Tognazzo, S, D'Andrea, E, Fox, S, Yan, M, Rebbeck, T, Olopade, OI, Weitzel, JN, Lynch, HT, Ganz, PA, Tomlinson, GE, Wang, X, Fredericksen, Z, Pankratz, VS, Lindor, NM, Szabo, C, Offit, K, Sakr, R, Gaudet, M, Bhatia, J, Kauff, N, Singer, CF, Tea, M-K, Gschwantler-Kaulich, D, Fink-Retter, A, Mai, PL, Greene, MH, Imyanitov, E, O'Malley, FP, Ozcelik, H, Glendon, G, Toland, AE, Gerdes, A-M, Thomassen, M, Kruse, TA, Jensen, UB, Skytte, A-B, Caligo, MA, Soller, M, Henriksson, K, Wachenfeldt, VA, Arver, B, Stenmark-Askmalm, M, Karlsson, P, Ding, YC, Neuhausen, SL, Beattie, M, Pharoah, PDP, Moysich, KB, Nathanson, KL, Karlan, BY, Gross, J, John, EM, Daly, MB, Buys, SM, Southey, MC, Hopper, JL, Terry, MB, Chung, W, Miron, AF, Goldgar, D, Chenevix-Trench, G, Easton, DF, Andrulis, IL & Antoniou, AC 2011, 'Common breast cancer susceptibility alleles are associated with tumour subtypes in BRCA1 and BRCA2 mutation carriers: results from the Consortium of Investigators of Modifiers of BRCA1/2', Breast Cancer Research, vol. 13, no. 6.
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Ng, SP, Korda, R, Clements, M, Latz, I, Bauman, A, Bambrick, H, Liu, B, Rogers, K, Herbert, N & Banks, E 2011, 'Validity of self‐reported height and weight and derived body mass index in middle‐aged and elderly individuals in Australia', Australian and New Zealand Journal of Public Health, vol. 35, no. 6, pp. 557-563.
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Background: Body mass index (BMI) is an important measure of adiposity. While BMI derived from self-reported data generally agrees well with that derived from measured values, evidence from Australia is limited, particularly for the elderly. Methods: We compared self-reported with measured height and weight in a random sample of 608 individuals aged ≥45 from the 45 and Up Study, an Australian population-based cohort study. We assessed degree of agreement and correlation between measures, and calculated sensitivity and specificity to quantify BMI category misclassification. Results: On average, in males and females respectively, height was overestimated by 1.24cm (95% CI: 0.75-1.72) and 0.59cm (0.26-0.92); weight was underestimated by 1.68kg (-1.99-1.36) and 1.02kg (-1.24-0.80); and BMI based on self-reported measures was underestimated by 0.90kg/m2 (-1.09-0.70) and 0.60 kg/m2 (-0.75-0.45). Underestimation increased with increasing measured BMI. There were strong correlations between self-reported and measured height, weight and BMI (r=0.95, 0.99 and 0.95, respectively, p<0.001). While there was excellent agreement between BMI categories from self-reported and measured data (kappa=0.80), obesity prevalence was underestimated. Findings did not differ substantially between middleaged and elderly participants. Conclusions: Self-reported data on height and weight quantify body size appropriately in middle-aged and elderly individuals for relative measures, such as quantiles of BMI. However, caution is necessary when reporting on absolute BMI and standard BMI categories, based on self-reported data, particularly since use of such data is likely to result in underestimation of the prevalence of obesity. © 2011 The Authors.
O’Brian, S, Jones, M, Packman, A, Menzies, R & Onslow, M 2011, 'Stuttering severity and educational attainment', Journal of Fluency Disorders, vol. 36, no. 2, pp. 86-92.
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Purpose: This study investigated the relationship between self-reported stuttering severity ratings and educational attainment. Method: Participants were 147 adults seeking treatment for stuttering. At pretreatment assessment, each participant reported the highest educational level they had attained and rated their typical and worst stuttering severity on a 9-point scale for a range of speaking situations. These included: (1) talking with a family member, (2) talking with a familiar person, not a family member, (3) talking in a group of people, (4) talking with a stranger, (5) talking with an authority figure such as a work manager or teacher, (6) talking on the telephone, (7) ordering food or drink, and (8) giving their name and address. Results: There was a significant negative relationship between highest educational achievement and mean self-reported stuttering severity rating for the eight situations. Conclusions: Future research is needed to investigate how this result should be addressed in educational institutions.Educational objectives: The reader will be able to: (1) describe the negative effects of stuttering through childhood to adulthood; (2) identify some of the negative consequences associated with stuttering on peer and teacher relationships, and academic performance at school; and (3) summarise the relationship between stuttering severity and educational attainment. © 2011 Elsevier Inc.
O'Brian, S & Onslow, M 2011, 'Clinical management of stuttering in children and adults', BMJ, vol. 342, no. jun24 1, pp. d3742-d3742.
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Ohnesorg, T, Turbitt, E & White, SJ 2011, 'The Many Faces of MLPA', Methods in molecular biology (Clifton, N.J.), vol. 687, pp. 193-205.
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Multiplex Ligation-dependent Probe Amplification (MLPA) is a PCR-based technique that was developed for identifying deletions and duplications in genomic DNA. The simplicity and sensitivity of this approach has led to it being implemented in many laboratories around the world. Since the original publication, there have been several variants of MLPA described, allowing the quantitative analysis of mRNA transcript levels, CpG methylation, complex genomic regions, and DNaseI hypersensitive sites. This chapter outlines the basic MLPA protocol, describes the different modifications and applications that have been published, and discusses the critical points during each of the steps.
Onslow, M, Packman, A & Howell, P 2011, 'Stuttering studies support treatment', Nature, vol. 470, no. 7335, pp. 465-465.
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Pont, L & Ball, P 2011, 'In the face of adversity', Australian Journal of Pharmacy, vol. 92, no. 1090, p. 36.
Power, E, Anderson, A & Togher, L 2011, 'Applying the WHO ICF framework to communication assessment and goal setting in Huntington's Disease: A case discussion', Journal of Communication Disorders, vol. 44, no. 3, pp. 261-275.
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Queddeng, K, Chaar, B & Williams, K 2011, 'Emergency contraception in Australian community pharmacies: a simulated patient study', Contraception, vol. 83, no. 2, pp. 176-182.
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Background: Australia joined the worldwide movement to increase the availability of the emergency contraceptive pill (ECP) by rescheduling from Prescription to Pharmacist Only status in 2004. However a protocol developed to aid in the provision of the ECP placed extensive requirements on the pharmacist. This study investigated the provision of the ECP by community pharmacists in Sydney, Australia. Study Design: Using a simulated patient methodology, 100 community pharmacies were visited over a five week period (AugOct 2008). The simulated patient specifically requested the ECP, and details of the consultation were recorded on a standardised data collection form. Results: The ECP was supplied in 95% of the pharmacies visited. Patient privacy was observed in 90% of consultations, which in general were succinct and friendly. Clinical assessment of the patient that met all the requirements was observed in 18%, partial assessment in 69%, and inadequate assessment in 13% of consultations. Provision of required information to the patient was sufficient in 42%, partial in 55%, and inadequate in 3% of consultations. Conclusions: This study highlighted a need to standardize procedures in regard to the ECP service to present a more consistent level of service to the public. Suggestions to improve the service include complete revision and simplification of the current protocol and improved training. Additionally, mandatory provision of private consultation areas and continuing professional education may facilitate and enhance quality counselling.
Ramus, SJ, Kartsonaki, C, Gayther, SA, Pharoah, PDP, Sinilnikova, OM, Beesley, J, Chen, X, McGuffog, L, Healey, S, Couch, FJ, Wang, X, Fredericksen, Z, Peterlongo, P, Manoukian, S, Peissel, B, Zaffaroni, D, Roversi, G, Barile, M, Viel, A, Allavena, A, Ottini, L, Papi, L, Gismondi, V, Capra, F, Radice, P, Greene, MH, Mai, PL, Andrulis, IL, Glendon, G, Ozcelik, H, Thomassen, M, Gerdes, A-M, Kruse, TA, Cruger, D, Jensen, UB, Caligo, MA, Olsson, H, Kristoffersson, U, Lindblom, A, Arver, B, Karlsson, P, Stenmark Askmalm, M, Borg, A, Neuhausen, SL, Ding, YC, Nathanson, KL, Domchek, SM, Jakubowska, A, Lubinski, J, Huzarski, T, Byrski, T, Gronwald, J, Gorski, B, Cybulski, C, Debniak, T, Osorio, A, Duran, M, Tejada, M-I, Benitez, J, Hamann, U, Rookus, MA, Verhoef, S, Tilanus-Linthorst, MA, Vreeswijk, MP, Bodmer, D, Ausems, MGEM, van Os, TA, Asperen, CJ, Blok, MJ, Meijers-Heijboer, HEJ, Peock, S, Cook, M, Oliver, C, Frost, D, Dunning, AM, Evans, DG, Eeles, R, Pichert, G, Cole, T, Hodgson, S, Brewer, C, Morrison, PJ, Porteous, M, Kennedy, MJ, Rogers, MT, Side, LE, Donaldson, A, Gregory, H, Godwin, A, Stoppa-Lyonnet, D, Moncoutier, V, Castera, L, Mazoyer, S, Barjhoux, L, Bonadona, V, Leroux, D, Faivre, L, Lidereau, R, Nogues, C, Bignon, Y-J, Prieur, F, Collonge-Rame, M-A, Venat-Bouvet, L, Fert-Ferrer, S, Miron, A, Buys, SS, Hopper, JL, Daly, MB, John, EM, Terry, MB, Goldgar, D, Hansen, TVO, Jonson, L, Ejlertsen, B, Agnarsson, BA, Offit, K, Kirchhoff, T, Vijai, J, Dutra-Clarke, AVC, Przybylo, JA, Montagna, M, Casella, C, Imyanitov, EN, Janavicius, R, Blanco, I, Lazaro, C, Moysich, KB, Karlan, BY, Gross, J, Beattie, MS, Schmutzler, R, Wappenschmidt, B, Meindl, A, Ruehl, I, Fiebig, B, Sutter, C, Arnold, N, Deissler, H, Varon-Mateeva, R, Kast, K, Niederacher, D, Gadzicki, D, Caldes, T, de la Hoya, M, Nevanlinna, H, Aittomaki, K, Simard, J, Soucy, P, Spurdle, AB, Holland, H, Chenevix-Trench, G, Easton, DF & Antoniou, AC 2011, 'Genetic Variation at 9p22.2 and Ovarian Cancer Risk for BRCA1 and BRCA2 Mutation Carriers', JNCI Journal of the National Cancer Institute, vol. 103, no. 2, pp. 105-116.
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Roberts, TV, Sutton, G, Lawless, MA, Jindal-Bali, S & Hodge, C 2011, 'Capsular block syndrome associated with femtosecond laser–assisted cataract surgery', Journal of Cataract and Refractive Surgery, vol. 37, no. 11, pp. 2068-2070.
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We report intraoperative capsular block syndrome occuring during the first 50 femtosecond laser-assisted cataract surgeries performed in our facility. Two patients had uneventful combined laser fragmentation, capsulotomy, and corneal incision procedures. In both cases, following transfer to the operating room and manual removal of the laser-cut capsulotomy, posterior capsule rupture was noted during hydrodissection, resulting in posterior dislocation of the lens. Pars plana vitrectomy, removal of the crystalline lens, and sulcus implantation of an intraocular lens were performed in both patients with good visual outcomes. Femtosecond laser-assisted cataract surgery changes the intraoperative environment with the generation of intracapsular gas and laser-induced changes in the cortex. With awareness of the changed intraocular environment following laser lens fragmentation and capsulotomy and a modification of the surgical technique, no additional cases of intraoperative CBS have been seen in more than 600 laser-assisted cataract surgery procedures performed to date at our facility. Financial Disclosure: No author has a financial or proprietary interest in any material or method mentioned. Additional disclosure is found in the footnotes. © 2011 ASCRS and ESCRS.
Rose, TA, Worrall, LE, Hickson, LM & Hoffmann, TC 2011, 'Aphasia friendly written health information: Content and design characteristics', International Journal of Speech-Language Pathology, vol. 13, no. 4, pp. 335-347.
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Rose, TA, Worrall, LE, Hickson, LM & Hoffmann, TC 2011, 'Exploring the use of graphics in written health information for people with aphasia', Aphasiology, vol. 25, no. 12, pp. 1579-1599.
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Saad, A, Hodge, C, Lawless, M & Gatinel, D 2011, 'Retrospective testing of a new method for detecting ectasia-susceptible corneas', Journal of Cataract and Refractive Surgery, vol. 37, no. 10, pp. 1907-1908.
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Schellingerhout, JM, Heymans, MW, Verhagen, AP, de Vet, HC, Koes, BW & Terwee, CB 2011, 'Measurement properties of translated versions of neck-specific questionnaires: a systematic review', BMC Medical Research Methodology, vol. 11, no. 1.
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Smith, JA, Dancyger, C, Wallace, M, Jacobs, C & Michie, S 2011, 'The Development of a Methodology for Examining the Process of Family Communication of Genetic Test Results', Journal of Genetic Counseling, vol. 20, no. 1, pp. 23-34.
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AbstractIt is important to study communication processes in families where members are undergoing testing for genetic conditions because the information received from such testing is crucial not just to the individual concerned but also to other members of the biological family. This topic has received little research attention, in part because of the complexities of methodology required. In this paper we present the development of a method specifically designed for the examination of the content and process of communication of genetic information in families. The method aims to maximize ecological validity as far as is possible. We describe how participants and other family members are recruited and how data were collected. We outline three main data analytic strategies: a graphic to show how genetic information changes as it flows from clinic and through the family, an intensive qualitative analysis of the meaning and impact of the genetic information to different family members, and an informative genogram which plots key family dynamics. This method will be illustrated in relation to a study of ten family‐groups where one individual has been found to carry a genetic mutation predisposing them to hereditary breast and ovarian cancer.
Spence, J, Titov, N, Dear, BF, Johnston, L, Solley, K, Lorian, C, Wootton, B, Zou, J & Schwenke, G 2011, 'Randomized controlled trial of Internet-delivered cognitive behavioral therapy for posttraumatic stress disorder', Depression and Anxiety, vol. 28, no. 7, pp. 541-550.
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Spence, J, Titov, N, Solley, K, Dear, BF, Johnston, L, Wootton, B, Kemp, A, Andrews, G, Zou, J, Lorian, C & Choi, I 2011, 'Characteristics and Treatment Preferences of People with Symptoms of Posttraumatic Stress Disorder: An Internet Survey', PLoS ONE, vol. 6, no. 7, pp. e21864-e21864.
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Background: Although Posttraumatic Stress Disorder (PTSD) is a severe and disabling anxiety disorder, relatively few people with this condition access evidence-based care. Barriers to treatment are multiple and complex, but the emerging field of Internet therapy for PTSD may improve access to evidence-based treatment. However, little is known about the characteristics of people with PTSD who seek online treatment, or whether they perceive internet treatment as an acceptable treatment option. Methodology: An online survey was used to collect information about the demographic and symptom characteristics of individuals with elevated levels of PTSD symptoms, and this was compared to data from corresponding sample from a national survey. Previous treatment experiences, perceived barriers to treatment and treatment preferences for Internet therapy and face-to-face treatment were also compared. Principal Findings: High levels of PTSD symptoms were reported by survey respondents. Psychological distress and disability was greater than reported by individuals with PTSD from a national survey. Half of the sample reported not having received treatment for PTSD; however, 88% of those who reported receiving treatment stated they received an evidence-based treatment. Primary barriers to treatment included cost, poor awareness of service availability, lack of prior treatment response and not perceiving personal distress as severe enough to warrant treatment. Most survey respondents indicated they were willing to try Internet treatment for PTSD. Conclusions: The Internet sample was symptomatically severe and multiple barriers existed to treatment. Internet therapy is an acceptable option for the treatment of PTSD in an internet sample. © 2011 Spence et al.
Starcevic, V, Berle, D, Brakoulias, V, Sammut, P, Moses, K, Milicevic, D & Hannan, A 2011, 'Functions of Compulsions in Obsessive–Compulsive Disorder', Australian & New Zealand Journal of Psychiatry, vol. 45, no. 6, pp. 449-457.
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Objectives: The key function of compulsions in obsessive–compulsive disorder (OCD) is to alleviate anxiety or distress caused by the obsessions, but compulsions may also have other functions. The main aim of this study was to systematically ascertain what motivates individuals with OCD to perform compulsions.Method: A total of 108 adults with OCD were assessed with the Yale-Brown Obsessive Compulsive Scale (Y-BOCS) and the Functions of Compulsions Interview. The latter instrument elicits the functions of identified compulsions.Results: The functions of 218 compulsions were identified. The mean number of functions per compulsion in the whole sample was 2.94 and the vast majority of compulsions (85.3%) were performed for more than one reason. The total number of functions of compulsions endorsed for the three main compulsions correlated with Y-BOCS total scores (r = 0.37, p < 0.001). Compulsions were most frequently performed automatically and to decrease distress or anxiety, but there was substantial variation, depending on the type of compulsion. Hoarding was often performed for reasons not related to any other compulsion (involving a perceived need for collected objects), whereas ordering/symmetry/repeating compulsions were frequently performed to achieve a ‘just right’ feeling. Checking was frequently performed because of the belief that something bad or unpleasant would happen if one failed to check; washing/cleaning compulsions were most frequently performed to decrease distress or anxiety and automatically, and mental compulsions were performed automatically far more often than for other reasons.Conclusions: The majority of compulsions have more than one function and they are often performed automatically. The finding of different functions of compulsions in different types of compulsions provides some support to the subtyping of OCD on the basis of obsessions and compulsions. Identifyin...
Starcevic, V, Berle, D, Brakoulias, V, Sammut, P, Moses, K, Milicevic, D & Hannan, A 2011, 'The Nature and Correlates of Avoidance in Obsessive–Compulsive Disorder', Australian & New Zealand Journal of Psychiatry, vol. 45, no. 10, pp. 871-879.
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Objectives: Avoidance in obsessive–compulsive disorder (OCD) has been neglected by research. This study aimed (i) to collect information on the nature and frequency of avoidance in people with OCD and ascertain the types of obsessions related to avoidance; (ii) compare OCD individuals with and without avoidance, and (iii) determine predictors of avoidance in people with OCD. Method: A total of 124 OCD adults underwent a comprehensive assessment. Participants were asked whether they engaged in any avoidance behaviour because of their OCD, and the nature and number of instances of such avoidance were recorded. The instances of avoidance were grouped according to the type of obsession and compulsion that they were related to. Results: A total of 74 (59.7%) participants reported OCD-related avoidance. Avoidance was most commonly related to contamination obsessions. Almost 80% of all contamination obsessions and more than 50% of all aggressive obsessions were associated with avoidance, and contamination obsessions were significantly more common among the participants with avoidance. In contrast, very few obsessions about a need to collect and keep objects and obsessions about a need for ordering, arranging and doing things right or in an exact way were associated with avoidance; these types of obsessions were also significantly more common among the participants without avoidance. The strongest predictor of avoidance was the presence of contamination obsessions. Participants with avoidance had a significantly more severe OCD than those without avoidance. Conclusions: Avoidance is common in OCD, and it is particularly frequently associated with contamination obsessions. There is a weak link between avoidance and hoarding and between avoidance and ordering/arranging/symmetry obsessions and compulsions. These results, along with the finding that OCD with avoidance is a more severe illness, have impl...
Starcevic, V, Berle, D, Porter, G & Fenech, P 2011, 'Problem Video Game Use and Dimensions of Psychopathology', International Journal of Mental Health and Addiction, vol. 9, no. 3, pp. 248-256.
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Stubbs, PW, Nielsen, JF, Sinkjær, T & Mrachacz-Kersting, N 2011, 'Phase Modulation of the Short-Latency Crossed Spinal Response in the Human Soleus Muscle', Journal of Neurophysiology, vol. 105, no. 2, pp. 503-511.
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Short-latency spinally mediated interlimb reflex pathways were recently reported between the left and right soleus muscles in the human lower-limb during sitting. The aim of the current study was to establish if these pathways were observed during a functional motor task such as human gait and modulated by the gait cycle phase and/or electrical stimulation intensity. The second aim was to elucidate on the afferents involved. Two interventions were investigated. First was ipsilateral tibial nerve (iTN) stimulation at motor threshold (MT), 35% of the maximal peak-to-peak M-wave (M-Max) and 85% M-Max (85M-Max) with stimuli applied at 60×, 70×, 80×, 90×, and 100% of the gait cycle of the ipsilateral leg. Second was ipsilateral sural nerve (SuN) and medial plantar nerve (MpN) stimulation at 1, 2, and 3 perceptual threshold at 90% of the gait cycle. The root mean squared (RMS) of the contralateral soleus (cSOL) responses were analyzed in a time window, 40–55 ms (or 45–60 ms for subjects >50 y/o) following iTN stimulation. The most consistent responses occurred at 90 and 100% of the gait cycle at higher stimulation intensities of the iTN. Significantly inhibitory responses ( P = 0.006) were reported at 60 versus 80% ( P = 0.03), 90% ( P = 0.006), and 100% ( P = 0.002) and 70 versus 90% ( P = 0.02) and 100% ( P = 0.009) of the gait cycle at 85M-Max. The responses became more inhibitory with increasing stimulation intensities at 80% ( P = 0.01), 90% ( P = 0.001), and 100% ( P = 0.004) of the gait cycle. Stimulation of the MpN and SuN at all stimulation intensities demonstrated no short-latency responses. Therefore, it is unlikely that afferents within these nerves contribute to the response. This is the first study to show short-latency spinally mediated responses in the cSOL following iTN stimulation, during walking. It provides evidence for a new spinal pathway contributing to motor control and demonstrates that the response likely has functional r...
Stubbs, PW, Nielsen, JF, Sinkjær, T & Mrachacz‐Kersting, N 2011, 'Crossed spinal soleus muscle communication demonstrated by H‐reflex conditioning', Muscle & Nerve, vol. 43, no. 6, pp. 845-850.
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AbstractIntroduction: A conditioning volley to the ipsilateral tibial nerve (iTN) inhibits contralateral soleus (cSOL) electromyographic activity at latencies of 37–41 ms. This is evidence for spinal muscular communication in opposing limbs. The aim of our study was to determine whether the cSOL H‐reflex would be inhibited in a similar manner. Methods: Thirteen subjects participated in two experiments: (1) stimuli delivered to the iTN at 85% of the maximal peak‐to‐peak M‐wave (85% M‐max) with a pre‐contracted cSOL; (2) 510 stimuli delivered at 85% M‐max to the iTN with a test volley delivered to the contralateral tibial nerve at interstimulus intervals of −6 to 100 ms. Results: Significant inhibition was observed in the cSOL H‐reflex when conditioning stimuli were delivered 3–33 ms before the test H‐reflex. Conclusions: The activity of this spinal pathway can be quantified using H‐reflex conditioning to provide a controlled model for further studies of this response. Muscle Nerve, 2011
Sutton, E, Hughes, J, White, S, Sekido, R, Tan, J, Arboleda, V, Rogers, N, Knower, K, Rowley, L, Eyre, H, Rizzoti, K, McAninch, D, Goncalves, J, Slee, J, Turbitt, E, Bruno, D, Bengtsson, H, Harley, V, Vilain, E, Sinclair, A, Lovell-Badge, R & Thomas, P 2011, 'Identification of SOX3 as an XX male sex reversal gene in mice and humans', Journal of Clinical Investigation, vol. 121, no. 1, pp. 328-341.
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Taş, Ü, Steyerberg, EW, Bierma-Zeinstra, SMA, Hofman, A, Koes, BW & Verhagen, AP 2011, 'Age, gender and disability predict future disability in older people: the Rotterdam Study', BMC Geriatrics, vol. 11, no. 1.
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Abstract Background To develop a prediction model that predicts disability in community-dwelling older people. Insight in the predictors of disability is needed to target preventive strategies for people at increased risk. Methods Data were obtained from the Rotterdam Study, including subjects of 55 years and over. Subjects who had complete data for sociodemographic factors, life style variables, health conditions, disability status at baseline and complete data for disability at follow-up were included in the analysis. Disability was expressed as a Disability Index (DI) measured with the Health Assessment Questionnaire. We used a multivariable polytomous logistic regression to derive a basic prediction model and an extended prediction model. Finally we developed readily applicable score charts for the calculation of outcome probabilities. Results Of the 5027 subjects included, 49% had no disability, 18% had mild disability, 16% had severe disability and 18% had deceased at follow-up after six years. The strongest predictors were age and prior disability. The contribution of other predictors was relatively small. The discriminative ability of the basic model was high; the extended model did not enhance predictive ability. Conclusion As prior disability status predicts future disability status, interventive strategies should be aimed at preventing disability in the first place.
Terwee, CB, Schellingerhout, JM, Verhagen, AP, Koes, BW & de Vet, HCW 2011, 'Methodological Quality of Studies on the Measurement Properties of Neck Pain and Disability Questionnaires: A Systematic Review', Journal of Manipulative and Physiological Therapeutics, vol. 34, no. 4, pp. 261-272.
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Teske, PR, Rius, M, McQuaid, CD, Styan, CA, Piggott, MP, Benhissoune, S, Fuentes-Grünewald, C, Walls, K, Page, M, Attard, CRM, Cooke, GM, McClusky, CF, Banks, SC, Barker, NP & Beheregaray, LB 2011, ''Nested' cryptic diversity in a widespread marine ecosystem engineer: a challenge for detecting biological invasions', BMC Evolutionary Biology, vol. 11, no. 1.
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Togher, L, Yiannoukas, C, Lincoln, M, Power, E, Munro, N, Mccabe, P, Ghosh, P, Worrall, L, Ward, E, Ferguson, A, Harrison, E & Douglas, J 2011, 'Evidence-based practice in speech-language pathology curricula: A scoping study', International Journal of Speech-Language Pathology, vol. 13, no. 6, pp. 459-468.
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Trajkovski, N, Andrews, C, Onslow, M, O'Brian, S, Packman, A & Menzies, R 2011, 'A phase II trial of the Westmead Program: Syllable-timed speech treatment for pre-school children who stutter', International Journal of Speech-Language Pathology, vol. 13, no. 6, pp. 500-509.
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This report presents a Phase II clinical trial of a syllable-timed speech treatment for early stuttering known as The Westmead Program. Of 17 children recruited, eight children aged between 34.5 years (mean 3 years 8 months) completed the treatment. The primary outcome measure was percentage syllables stuttered (%SS) measured from independent, blinded speech assessments of beyond-clinic audio recordings. Secondary outcomes were measures of treatment time, speech quality, and parent severity ratings. Dropouts occurred, but at a similar rate to other clinical trials of this nature. For the eight children who completed the treatment, mean pre-treatment stuttering was 6.0%SS and at 12-months post-Stage 2 entry stuttering had decreased to 0.2%SS, representing a mean stuttering reduction of 96%. A large effect size was obtained with a mean of 8.0 clinical hours required for these children to reach Stage 2. Independent listeners judged the everyday speech of all children to be not unnatural in any way. Stuttering reductions were attained with clinical efficiency and simplicity compared to other early stuttering interventions. Further clinical trials development of the treatment is warranted. © 2011 The Speech Pathology Association of Australia Limited.
Tu, LV, Togher, L & Power, E 2011, 'The impact of communication partner and discourse task on a person with traumatic brain injury: The use of multiple perspectives', Brain Injury, vol. 25, no. 6, pp. 560-580.
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Ude, M, Schuessel, K, Quinzler, R, Leuner, K, Müller, WE & Schulz, M 2011, 'Generic switch after ramipril patent expiry is not associated with decreased pharmacy refill compliance', Journal of Hypertension, vol. 29, no. 9, pp. 1837-1845.
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van Middelkoop, M, Rubinstein, SM, Kuijpers, T, Verhagen, AP, Ostelo, R, Koes, BW & van Tulder, MW 2011, 'A systematic review on the effectiveness of physical and rehabilitation interventions for chronic non-specific low back pain', European Spine Journal, vol. 20, no. 1, pp. 19-39.
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van Rijn, RM, Willemsen, SP, Verhagen, AP, Koes, BW & Bierma-Zeinstra, SMA 2011, 'Explanatory Variables for Adult Patients' Self-Reported Recovery After Acute Lateral Ankle Sprain', Physical Therapy, vol. 91, no. 1, pp. 77-84.
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Background Longitudinal research on musculoskeletal disorders often makes use of a single measure of recovery, despite the large variation in reported recovery that exists. Patients with an acute ankle sprain often experience no pain or functional disability following treatment, yet report not being fully recovered, or vice versa. Objective The purpose of this study was to find explanatory variables for reporting recovery by analyzing the extent to which different outcomes (eg, pain intensity) were associated with recovery and how baseline scores of different variables influence this association in adult patients after acute lateral ankle sprain. Design This was a cohort study based on data collected in a randomized controlled trial (RCT). Methods This study was constructed within the framework of an RCT. One hundred two patients who incurred an acute ankle sprain were included. Recovery, pain intensity, giving way of the ankle, and Ankle Function Score (AFS) were assessed during the RCT at baseline and at 4 weeks, 8 weeks, 3 months, and 12 months postinjury. Mean differences were calculated between baseline and follow-up. Associations were calculated using linear mixed models, and the influence of baseline scores on these associations was determined using linear regression with interaction. Results Associations were found between recovery and the mean differen...
Vassallo, S, Douglas, J & White, E 2011, 'Visual Scanning in the Recognition of Facial Affect in Traumatic Brain Injury', i-Perception, vol. 2, no. 4, pp. 250-250.
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Verhagen, AP, Lewis, M, Schellingerhout, JM, Heymans, MW, Dziedzic, K, de Vet, HCW & Koes, BW 2011, 'Do whiplash patients differ from other patients with non-specific neck pain regarding pain, function or prognosis?', Manual Therapy, vol. 16, no. 5, pp. 456-462.
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Vijfvinkel, FA, Schiphof, D & Verhagen, AP 2011, 'Further questions remain concerning osteoarthritis risk and index finger-to-ring finger length ratios: Comment on the article by Haugen et al', Arthritis & Rheumatism, vol. 63, no. 12, pp. 4038-4038.
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White, S, Ohnesorg, T, Notini, A, Roeszler, K, Hewitt, J, Daggag, H, Smith, C, Turbitt, E, Gustin, S, van den Bergen, J, Miles, D, Western, P, Arboleda, V, Schumacher, V, Gordon, L, Bell, K, Bengtsson, H, Speed, T, Hutson, J, Warne, G, Harley, V, Koopman, P, Vilain, E & Sinclair, A 2011, 'Copy Number Variation in Patients with Disorders of Sex Development Due to 46,XY Gonadal Dysgenesis', PLoS ONE, vol. 6, no. 3, pp. e17793-e17793.
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Williams, KA, Emmerton, LM, Taylor, R, Werner, J & Benrimoj, SI 2011, 'Non-prescription medicines and Australian community pharmacy interventions: rates and clinical significance', International Journal of Pharmacy Practice, vol. 19, no. 3, pp. 156-165.
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Abstract Objective To quantify pharmacy intervention rates for non-prescription medications (pharmacist-only and pharmacy medicines), to document the clinical significance of these interventions and to determine the adverse health consequences and subsequent health care avoided as a result of the interventions. Methods Non-prescription medicines interventions undertaken by community pharmacy staff were recorded in two field studies: a study of all Australian pharmacies to determine incidence rates for low-incidence, highly significant interventions, and a study of a sample of pharmacies to collect data on all non-prescription interventions. Recorded interventions were assessed by a clinical panel for clinical significance, potential adverse health consequence avoided, probability and likely duration of the adverse health consequence. Key findings The rate of professional intervention that occurs in Australia for pharmacist-only and pharmacy medicines is 5.66 per 1000 unit sales (95% confidence interval 4.79–6.64). Rates of intervention varied by clinical significance. When considering health care avoided, the main impact of the interventions was avoidance of urgent general practitioner (GP) visits, followed by avoidance of regular GP visits and accident and emergency treatment. The most common adverse health consequences avoided were exacerbations of an existing condition (e.g. hypertension, asthma) and adverse drug effects. Conclusions This study de...
Wootton, BM, Titov, N, Dear, BF, Spence, J & Kemp, A 2011, 'The Acceptability of Internet-Based Treatment and Characteristics of an Adult Sample with Obsessive Compulsive Disorder: An Internet Survey', PLoS ONE, vol. 6, no. 6, pp. e20548-e20548.
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Background: Obsessive-compulsive disorder (OCD) is a disabling anxiety disorder, but most individuals delay seeking treatment. Internet-based cognitive behavioural therapy (iCBT) is an innovative service delivery method that may help to improve access to care, but the acceptability to consumers of such programs has not yet been established. Methodology: People with symptoms of OCD were invited to complete an online survey enquiring about demographic characteristics, symptom severity, and acceptability of Internet-based treatment. Demographic and symptom severity data were compared with people with OCD identified in a national epidemiological survey and with a sample of patients with OCD from a specialist outpatient anxiety clinic. Participants: 129 volunteers to an online Internet survey, 135 patients at a specialist anxiety disorders outpatient clinic, and 297 cases identified in a national epidemiological survey. Main Measures: Demographic characteristics, and severity of symptoms as measured by the Kessler 10-Item scale, the 12-item World Health Organisation Disability Assessment Schedule - Second Edition and the Yale Brown Obsessive Compulsive Scale - Self Report Version. Principal Findings: The Internet sample was similar demographically but reported more severe symptoms than the comparison groups, although had similar severity of symptoms of OCD compared with other clinical samples reported in the literature. Participants reported Internet-based treatment for OCD would be highly acceptable. Conclusions: Internet-based treatment may reduce barriers to accessing treatment to people with OCD. Individuals in this study were similar demographically to other samples and had similar severity of symptoms as those identified in other clinical samples, suggesting that Internet-based treatment using techniques employed in face-to-face treatment may be effective in this group. Internet-based treatments for OCD need to be developed and evaluated. © 2011 Wootton et al.
Wootton, BM, Titov, N, Dear, BF, Spence, J, Andrews, G, Johnston, L & Solley, K 2011, 'An Internet administered treatment program for obsessive–compulsive disorder: A feasibility study', Journal of Anxiety Disorders, vol. 25, no. 8, pp. 1102-1107.
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