Publications

Bhatt, S, Eri, RE, Goh, B-H, Paudel, KR, Pinto, TDJA & Dua, K 2024, Immunotherapy Against Lung Cancers Emerging Opportunities and Challenges, Springer.
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This book provides insight into the various immunotherapeutic approaches for the treatment of lung cancers.

Choi, AH, Choi, G & Ben-Nissan, B 2024, 'Surface modification and its influence on osseointegration of implants' in Multiscale Cell-Biomaterials Interplay in Musculoskeletal Tissue Engineering and Regenerative Medicine, Elsevier, pp. 93-111.
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Johnston, NP, Krosch, MN, Archer, MS & Wallman, JF 2024, 'Entomology' in Reference Module in Social Sciences, Elsevier.
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Martin, L, Thomas, P, de Silva, P & Sirivivatnanon, V 2024, 'Assessing the Role of ASR Reactive Aggregates in Concrete Mixes Susceptible to DEF' in RILEM Bookseries, Springer Nature Switzerland, pp. 168-175.
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Moore, CE & Griebel, A 2024, 'A Beginner’s Guide to Eddy Covariance: Methodology and Its Applications to Photosynthesis' in Methods in Molecular Biology, Springer US, pp. 227-256.
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Nucera, F, Hansbro, PM, Fairley, LH, Monaco, F, Uwagboe, I, Mumby, S, Adcock, IM & Caramori, G 2024, 'Stem Cells/Lung Organoids and Lung Rejuvenation in the Treatment of Chronic Obstructive Pulmonary Disease and Pulmonary Emphysema' in Reference Module in Biomedical Sciences, Elsevier.
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Platen, E & Tappe, S 2024, 'Exploiting Arbitrage Requires Short Selling' in Jarrow, R & Madan, D (eds), Peter Carr Gedenkschrift: Research Advances in Mathematical Finance, World Scientific, pp. 725-752.

Reimers, JR & Mckemmish, LK 2024, 'Unified Understanding of Structure, Reactivity and Spectroscopy Within General Valence Bond Scenarios, Obtained by Transferring Techniques Developed Within Electron-Transfer Theory' in Shaik, S & Hibberty, PC (eds), Comprehensive Computational Chemistry, Elsevier, pp. 662-682.
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Valence bond theory and electron transfer theory are both widely applied throughout Chemical Science, usually to different applications. Nevertheless, electron transfer theory is just an extensive development of one type of valence bond model. In this article, we demonstrate how electron-transfer theory can be more broadly applied to other valence-bond scenarios. This involves (1) rederivation for Morse oscillators of many key analytical expressions from electron-transfer transfer theory pertinent to harmonic oscillators, (2) renormalization of the key parameters from electron transfer theory to facilitate broad applications, and (3) development of 3 Morse-oscillator applications.

Sankaran, J, Rice, SA & Wohland, T 2024, 'Single Microcolony Diffusion Analysis in Pseudomonas aeruginosa Biofilms' in Methods in Molecular Biology, Springer US, pp. 153-168.
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Saribatir, E, Zurstraßen, N, Hildenbrand, D, Stock, F, Piña, AM, Wegner, FV, Yan, Z, Wen, S & Arnold, M 2024, 'Game Physics Engine Using Optimised Geometric Algebra RISC-V Vector Extensions Code Using Fourier Series Data' in Advances in Computer Graphics, Springer Nature Switzerland, pp. 250-261.
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Thomas, P, Martin, L, De Silva, P, Sirivivatnanon, V & Šimon, P 2024, 'Modelling the Kinetic Behaviour of Delayed Ettringite Formation in Concrete Prisms' in RILEM Bookseries, Springer Nature Switzerland, pp. 201-208.
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Abell-King, C, Pokhrel, A, Rice, SA, Duggin, IG & Söderström, B 2024, 'Multispecies bacterial invasion of human host cells', Pathogens and Disease, vol. 82.
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Abstract Urinary tract infection (UTI), one of the most common bacterial infections worldwide, is a typical example of an infection that is often polymicrobial in nature. While the overall infection course is known on a macroscale, bacterial behavior is not fully understood at the cellular level and bacterial pathophysiology during multispecies infection is not well characterized. Here, using clinically relevant bacteria, human epithelial bladder cells and human urine, we establish co-infection models combined with high resolution imaging to compare single- and multi-species bladder cell invasion events in three common uropathogens: uropathogenic Escherichia coli (UPEC), Klebsiella pneumoniae and Enterococcus faecalis. While all three species invaded the bladder cells, under flow conditions the Gram-positive E. faecalis was significantly less invasive compared to the Gram-negative UPEC and K. pneumoniae. When introduced simultaneously during an infection experiment, all three bacterial species sometimes invaded the same bladder cell, at differing frequencies suggesting complex interactions between bacterial species and bladder cells. Inside host cells, we observed encasement of E. faecalis colonies specifically by UPEC. During subsequent dispersal from the host cells, only the Gram-negative bacteria underwent infection-related filamentation (IRF). Taken together, our data suggest that bacterial multispecies invasions of single bladder cells are frequent and support earlier studies showing intraspecies cooperation on a biochemical level during UTI.

Adil, M, Mahmud, MAP, Kouzani, AZ & Khoo, SY 2024, 'Optimal Location and Pricing of Electric Vehicle Charging Stations Using Machine Learning and Stackelberg Game', IEEE Transactions on Industry Applications, vol. 60, no. 3, pp. 4708-4722.
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Akhileshwar Jha, L, Imran, M, Shrestha, J, Prasad Devkota, H, Bhattacharya, K, Alsayari, A, Wahab, S, Kumar Jha, S, Raj Paudel, K & Kesharwani, P 2024, 'Effectiveness of phytoconstituents and potential of phyto-nanomedicines combination to treat osteoarthritis', European Polymer Journal, pp. 113243-113243.
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Allam, VSRR, Patel, VK, De Rubis, G, Paudel, KR, Gupta, G, Chellappan, DK, Singh, SK, Hansbro, PM, Oliver, BGG & Dua, K 2024, 'Exploring the role of the ocular surface in the lung-eye axis: Insights into respiratory disease pathogenesis', Life Sciences, vol. 349, pp. 122730-122730.
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Alzahrani, SA, De Silva, KSB, Dowd, A, Arnold, MD & Cortie, MB 2024, 'Effect of precursor composition and heat-treatment on the morphology and physical properties of Ag nanosponges', Results in Surfaces and Interfaces, vol. 15, pp. 100217-100217.
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Angeloski, A, Flower‐Donaldson, K, Matar, F, Hayes, DC, Duman, MN, Oldfield, DT, Westerhausen, MT & McDonagh, AM 2024, 'Gold Microstructures by Thermolysis of Gold(III) Di‐isopropyldithiocarbamate Complexes', ChemNanoMat, vol. 10, no. 3.
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AbstractElemental gold was formed by thermolysis of gold(III) dithiocarbamate single‐source precursors, which exist as two complexes. The complexes were readily synthesised from the reaction between chloroauric acid and sodium di‐isopropyldithiocarbamate and could be isolated from each other. The thermal decomposition processes were evaluated using thermogravimetry and electrical resistance measurements. The structure and purity of the resultant gold was examined using scanning electron microscopy. The resultant gold materials were drastically different and dependent on the thermolysed complex.

Ashique, S, Mishra, N, Garg, A, Garg, S, Farid, A, Rai, S, Gupta, G, Dua, K, Paudel, KR & Taghizadeh-Hesary, F 2024, 'A Critical Review on the Long-Term COVID-19 Impacts on Patients With Diabetes', The American Journal of Medicine.
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Bahatheg, G, Kuppusamy, R, Yasir, M, Bridge, S, Mishra, SK, Cranfield, CG, StC. Black, D, Willcox, M & Kumar, N 2024, 'Dimeric peptoids as antibacterial agents', Bioorganic Chemistry, vol. 147, pp. 107334-107334.
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Balzer, MJ, Hitchcock, JN, Kobayashi, T, Westhorpe, DP, Boys, C & Mitrovic, SM 2024, 'Flow event size influences carbon, nutrient and zooplankton dynamics in a highly regulated lowland river', Hydrobiologia, vol. 851, no. 5, pp. 1319-1334.
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AbstractRiver regulation and water extraction has significantly altered flow regimes and reduced flood events in many inland river systems. Environmental flows have been adopted in many systems to mitigate the ecological impacts of river regulation, however a lack of knowledge regarding the interrelationship between flow regimes, carbon transport and instream productivity make prioritising water management difficult. To address this knowledge gap, we conducted a study on the Namoi River in the Murray-Darling Basin, Australia, monitoring changes in dissolved organic carbon (DOC), nutrient dynamics and planktonic food web structure during a period of variable flows. Nutrient and DOC concentrations were positively correlated with river discharge and zooplankton concentrations were highest post flow events. Planktonic chlorophyll-a, increased DOC concentration and higher discharge were the most influential drivers of change in zooplankton communities. Further, our results indicated that flow events increased production through both heterotrophic and autotrophic pathways, significantly boosting zooplankton concentration compared to base flow conditions across all measured flow events. We suggest even small in-channel flow events can be important for increasing basal and zooplankton production in rivers, and therefore should be protected or promoted by environmental flow management, particularly during drought conditions.

Bani Saeid, A, De Rubis, G, Williams, KA, Yeung, S, Chellappan, DK, Singh, SK, Gupta, G, Hansbro, PM, Shahbazi, M-A, Gulati, M, Kaur, IP, Santos, HA, Paudel, KR & Dua, K 2024, 'Revolutionizing lung health: Exploring the latest breakthroughs and future prospects of synbiotic nanostructures in lung diseases', Chemico-Biological Interactions, vol. 395, pp. 111009-111009.
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Banik, M, Paudel, KR, Majumder, R & Idrees, S 2024, 'Prediction of virus–host interactions and identification of hot spot residues of DENV-2 and SH3 domain interactions', Archives of Microbiology, vol. 206, no. 4.
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AbstractDengue virus, particularly serotype 2 (DENV-2), poses a significant global health threat, and understanding the molecular basis of its interactions with host cell proteins is imperative for developing targeted therapeutic strategies. This study elucidated the interactions between proline-enriched motifs and Src homology 3 (SH3) domain. The SH3 domain is pivotal in mediating protein–protein interactions, particularly by recognizing and binding to proline-rich regions in partner proteins. Through a computational pipeline, we analyzed the interactions and binding modes of proline-enriched motifs with SH3 domains, identified new potential DENV-2 interactions with the SH3 domain, and revealed potential hot spot residues, underscoring their significance in the viral life cycle. This comprehensive analysis provides crucial insights into the molecular basis of DENV-2 infection, highlighting conserved and serotype-specific interactions. The identified hot spot residues offer potential targets for therapeutic intervention, laying the foundation for developing antiviral strategies against Dengue virus infection. These findings contribute to the broader understanding of viral–host interactions and provide a roadmap for future research on Dengue virus pathogenesis and treatment.

Barash, M, McNevin, D, Fedorenko, V & Giverts, P 2024, 'Machine learning applications in forensic DNA profiling: A critical review', Forensic Science International: Genetics, vol. 69, pp. 102994-102994.
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Bartels, N, Camp, EF, Dilernia, NJ & Suggett, DJ 2024, 'Regulation of cultured coral endosymbiont photophysiology by alternate heat stress protocols', Marine Biology, vol. 171, no. 1.
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Bashir, B, Alam, S, Khandale, N, Birla, D, Vishwas, S, Pandey, NK, Gupta, G, Paudel, KR, Dureja, H, Kumar, P, Singh, TG, Kuppusamy, G, Zacconi, FC, Pinto, TDJA, Dhanasekaran, M, Gulati, M, Dua, K & Singh, SK 2024, 'Opening avenues for treatment of neurodegenerative disease using post-biotics: Breakthroughs and bottlenecks in clinical translation', Ageing Research Reviews, vol. 95, pp. 102236-102236.
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Bati, ASR, Myagmarsereejid, P, Fronzi, M, Fan, K, Liu, P, Zhong, YL, Burn, PL, Gentle, IR, Shaw, PE & Batmunkh, M 2024, 'Atomically Doped 2D Black Phosphorus for Efficient and Stable Perovskite Solar Cells', Small Structures, vol. 5, no. 2.
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Controlled functionalization of 2D black phosphorus (BP) nanosheets provides unique opportunities to tune their chemical, physical, and electronic properties. Herein, the preparation of single‐atom nickel‐doped BP (Ni–BP) sheets using a simple solution‐based strategy is reported. Using the Ni–BP sheets as a passivation layer on top of a perovskite film leads to standard perovskite solar cells (PSCs) with improved performance. The standard n–i–p PSCs with the Ni–BP interlayer achieve maximum power conversion efficiencies of over 22%, with negligible hysteresis and a modest improvement in stability when subjected to different testing conditions. The perovskite films prepared with Ni–BP sheets‐based passivation are found to have reduced defect densities as well as improved charge‐transfer properties and carrier lifetimes. Density‐functional theory calculations support the experimental results through showing that the atomic Ni‐doping increases the work function of the BP interlayer, enabling better hole extraction, as well as increasing the surface hydrophobicity of the BP layer, hence reducing water sorption into the perovskite film.

Bhat, AA, Afzal, M, Goyal, A, Gupta, G, Thapa, R, almalki, WH, Kazmi, I, Alzarea, SI, Shahwan, M, Paudel, KR, Ali, H, Sahu, D, Prasher, P, Singh, SK & Dua, K 2024, 'The impact of formaldehyde exposure on lung inflammatory disorders: Insights into asthma, bronchitis, and pulmonary fibrosis', Chemico-Biological Interactions, vol. 394, pp. 111002-111002.
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Bhattacharjee, NV, Schumacher, AE, Aali, A, Abate, YH, Abbasgholizadeh, R, Abbasian, M, Abbasi-Kangevari, M, Abbastabar, H, Abd ElHafeez, S, Abd-Elsalam, S, Abdollahi, M, Abdollahifar, M-A, Abdoun, M, Abdullahi, A, Abebe, M, Abebe, SS, Abiodun, O, Abolhassani, H, Abolmaali, M, Abouzid, M, Aboye, GB, Abreu, LG, Abrha, WA, Abrigo, MRM, Abtahi, D, Abualruz, H, Abubakar, B, Abu-Gharbieh, E, Abu-Rmeileh, NME, Adal, TGG, Adane, MM, Adeagbo, OAA, Adedoyin, RA, Adekanmbi, V, Aden, B, Adepoju, AV, Adetokunboh, OO, Adetunji, JB, Adeyinka, DA, Adeyomoye, OI, Adnani, QES, Adra, S, Afolabi, RF, Afyouni, S, Afzal, MS, Afzal, S, Aghamiri, S, Agodi, A, Agyemang-Duah, W, Ahinkorah, BO, Ahlstrom, AJ, Ahmad, A, Ahmad, D, Ahmad, F, Ahmad, MM, Ahmad, S, Ahmad, T, Ahmed, A, Ahmed, A, Ahmed, H, Ahmed, LA, Ahmed, MS, Ahmed, SA, Ajami, M, Aji, B, Akalu, GT, Akbarialiabad, H, Akinyemi, RO, Akkaif, MA, Akkala, S, Al Hamad, H, Al Hasan, SM, Al Qadire, M, AL-Ahdal, TMA, Alalalmeh, SO, Alalwan, TA, Al-Aly, Z, Alam, K, Al-amer, RM, Alanezi, FM, Alanzi, TM, Albakri, A, Albashtawy, M, AlBataineh, MT, Alemi, H, Alemi, S, Alemu, YM, Al-Eyadhy, A, Al-Gheethi, AAS, Alhabib, KF, Alhajri, N, Alhalaiqa, FAN, Alhassan, RK, Ali, A, Ali, BA, Ali, L, Ali, MU, Ali, R, Ali, SSS, Alif, SM, Aligol, M, Alijanzadeh, M, Aljasir, MAM, Aljunid, SM, Al-Marwani, S, Almazan, JU, Al-Mekhlafi, HM, Almidani, O, Alomari, MA, Al-Omari, B, Alqahtani, JS, Alqutaibi, AY, Al-Raddadi, RM, Al-Sabah, SK, Altaf, A, Al-Tawfiq, JA, Altirkawi, KA, Aluh, DO, Alvi, FJ, Alvis-Guzman, N, Alwafi, H, Al-Worafi, YM, Aly, H, Aly, S, Alzoubi, KH, Ameyaw, EK, Amin, TT, Amindarolzarbi, A, Amini-Rarani, M, Amiri, S, Ampomah, IG, Amugsi, DA, Amusa, GA, Ancuceanu, R, Anderlini, D, Andrade, PP, Andrei, CL, Andrei, T, Anil, A, Anil, S, Ansar, A, Ansari-Moghaddam, A, Antony, CM, Antriyandarti, E, Anvari, S, ANWAR, S, Anwer, R, Anyasodor, AE, Arabloo, J, Arabzadeh Bahri, R, Arafa, EA, Arafat, M, Araújo, AM, Aravkin, AY, Aremu, A, Aripov, T, Arkew, M, Armocida, B, Ärnlöv, J, Arooj, M, Artamonov, AA, Arulappan, J, Aruleba, RT, Arumugam, A, Asadi-Lari, M, Asemi, Z, Asgary, S, Asghariahmadabad, M, Asghari-Jafarabadi, M, Ashemo, MY, Ashraf, M, Ashraf, T, Asika, MO, Athari, SS, Atout, MMW, Atreya, A, Aujayeb, A, Ausloos, M, Avan, A, Aweke, AM, Ayele, GM, Ayyoubzadeh, SM, Azadnajafabad, S, Azevedo, RMS, Azzam, AY & et al. 2024, 'Global fertility in 204 countries and territories, 1950–2021, with forecasts to 2100: a comprehensive demographic analysis for the Global Burden of Disease Study 2021', The Lancet, vol. 403, no. 10440, pp. 2057-2099.
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Boyton, I, Valenzuela, SM, Collins-Praino, LE & Care, A 2024, 'Neuronanomedicine for Alzheimer’s and Parkinson’s disease: Current progress and a guide to improve clinical translation', Brain, Behavior, and Immunity, vol. 115, pp. 631-651.
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Neuronanomedicine is an emerging multidisciplinary field that aims to create innovative nanotechnologies to treat major neurodegenerative disorders, such as Alzheimer's (AD) and Parkinson's disease (PD). A key component of neuronanomedicine are nanoparticles, which can improve drug properties and demonstrate enhanced safety and delivery across the blood brain barrier, a major improvement on existing therapeutic approaches. In this review, we critically analyze the latest nanoparticle-based strategies to modify underlying disease pathology to slow or halt AD/PD progression. We find that a major roadblock for neuronanomedicine translation to date is a poor understanding of how nanoparticles interact with biological systems (i.e., bio-nano interactions), which is partly due to inconsistent reporting in published works. Accordingly, this review makes a set of specific recommendations to help guide researchers to harness the unique properties of nanoparticles and thus realise breakthrough treatments for AD/PD.

Bradfield, LA, Becchi, S & Kendig, MD 2024, 'Striatal Acetylcholine and Dopamine Interactions Produce SituationappropriateAction Selection', Current Neuropharmacology, vol. 22, no. 9, pp. 1491-1496.
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Abstract:Individuals often learn how to perform new actions for particular outcomes against a complex background of existing action-outcome associations. As such, this new knowledge can interfere or even compete with existing knowledge, such that individuals must use internal and external cues to determine which action is appropriate to the current situation. The question thus remains as to how this problem is solved at a neural level. Research over the last decade or so has begun to determine how the brain achieves situation-appropriate action selection. Several converging lines of evidence suggest that it is achieved through the complex interactions of acetylcholine and dopamine within the striatum in a manner that relies on glutamatergic inputs from the cortex and thalamus. Here we briefly review this evidence, then relate it to several very recent findings to provide new, speculative insights regarding the precise nature of striatal acetylcholine/dopamine interaction dynamics and their relation to situation-appropriate action selection.

Brauer, M, Roth, GA, Aravkin, AY, Zheng, P, Abate, KH, Abate, YH, Abbafati, C, Abbasgholizadeh, R, Abbasi, MA, Abbasian, M, Abbasifard, M, Abbasi-Kangevari, M, Abd ElHafeez, S, Abd-Elsalam, S, Abdi, P, Abdollahi, M, Abdoun, M, Abdulah, DM, Abdullahi, A, Abebe, M, Abedi, A, Abedi, A, Abegaz, TM, Abeldaño Zuñiga, RA, Abiodun, O, Abiso, TL, Aboagye, RG, Abolhassani, H, Abouzid, M, Aboye, GB, Abreu, LG, Abualruz, H, Abubakar, B, Abu-Gharbieh, E, Abukhadijah, HJJ, Aburuz, S, Abu-Zaid, A, Adane, MM, Addo, IY, Addolorato, G, Adedoyin, RA, Adekanmbi, V, Aden, B, Adetunji, JB, Adeyeoluwa, TE, Adha, R, Adibi, A, Adnani, QES, Adzigbli, LA, Afolabi, AA, Afolabi, RF, Afshin, A, Afyouni, S, Afzal, MS, Afzal, S, Agampodi, SB, Agbozo, F, Aghamiri, S, Agodi, A, Agrawal, A, Agyemang-Duah, W, Ahinkorah, BO, Ahmad, A, Ahmad, D, Ahmad, F, Ahmad, N, Ahmad, S, Ahmad, T, Ahmed, A, Ahmed, A, Ahmed, A, Ahmed, LA, Ahmed, MB, Ahmed, S, Ahmed, SA, Ajami, M, Akalu, GT, Akara, EM, Akbarialiabad, H, Akhlaghi, S, Akinosoglou, K, Akinyemiju, T, Akkaif, MA, Akkala, S, Akombi-Inyang, B, Al Awaidy, S, Al Hasan, SM, Alahdab, F, AL-Ahdal, TMA, Alalalmeh, SO, Alalwan, TA, Al-Aly, Z, Alam, K, Alam, N, Alanezi, FM, Alanzi, TM, Albakri, A, AlBataineh, MT, Aldhaleei, WA, Aldridge, RW, Alemayohu, MA, Alemu, YM, Al-Fatly, B, Al-Gheethi, AAS, Al-Habbal, K, Alhabib, KF, Alhassan, RK, Ali, A, Ali, A, Ali, BA, Ali, I, Ali, L, Ali, MU, Ali, R, Ali, SSS, Ali, W, Alicandro, G, Alif, SM, Aljunid, SM, Alla, F, Al-Marwani, S, Al-Mekhlafi, HM, Almustanyir, S, Alomari, MA, Alonso, J, Alqahtani, JS, Alqutaibi, AY, Al-Raddadi, RM, Alrawashdeh, A, Al-Rifai, RH, Alrousan, SM, Al-Sabah, SK, Alshahrani, NZ, Altaany, Z, Altaf, A, Al-Tawfiq, JA, Altirkawi, KA, Aluh, DO, Alvis-Guzman, N, Alvis-Zakzuk, NJ, Alwafi, H, Al-Wardat, MS, Al-Worafi, YM, Aly, H, Aly, S, Alzoubi, KH, Al-Zyoud, W, Amaechi, UA, Aman Mohammadi, M, Amani, R, Amiri, S, Amirzade-Iranaq, MH, Ammirati, E, Amu, H, Amugsi, DA, Amusa, GA, Ancuceanu, R, Anderlini, D, Anderson, JA, Andrade, PP, Andrei, CL, Andrei, T, Anenberg, SC, Angappan, D, Angus, C, Anil, A, Anil, S, Anjum, A, Anoushiravani, A, Antonazzo, IC, Antony, CM, Antriyandarti, E, Anuoluwa, BS, Anvari, D, Anvari, S, Anwar, S, Anwar, SL, Anwer, R, Anyabolo, EE, Anyasodor, AE, Apostol, GLC, Arabloo, J, Arabzadeh Bahri, R, Arafat, M, Areda, D, Aregawi, BB, Aremu, A & et al. 2024, 'Global burden and strength of evidence for 88 risk factors in 204 countries and 811 subnational locations, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021', The Lancet, vol. 403, no. 10440, pp. 2162-2203.
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Brown, AO, Green, PJ, Frankham, GJ, Stuart, BH & Ueland, M 2024, 'Correction to “Insights into the Effects of Violating Statistical Assumptions for Dimensionality Reduction for Chemical “-omics” Data with Multiple Explanatory Variables”', ACS Omega, vol. 9, no. 13, pp. 15724-15724.
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Buckley, T, Vuong, T, Karanam, K, Vo, PHN, Shukla, P, Firouzi, M & Rudolph, V 2024, 'Response to ‘Comment on “Using foam fractionation to estimate PFAS air-water interface adsorption behaviour at ng/L and µg/L” by T. Buckley, T. Vuong, K. Karanam, P.H.N. Vo, P. Shukla, M. Firouzi & V. Rudolph, Water research 239, 120028’', Water Research, vol. 249, pp. 120811-120811.
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Carr, LM, Mustafa, S, Care, A & Collins-Praino, LE 2024, 'More than a number: Incorporating the aged phenotype to improve in vitro and in vivo modeling of neurodegenerative disease', Brain, Behavior, and Immunity, vol. 119, pp. 554-571.
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Carter, DJ, Rahmani, A, Evans, R, Stratigos, A & Brown, J 2024, 'HIV-related Legal Needs, Demographic Change, and Trends in Australia since 1992: A Review of Legal Administrative Data', AIDS and Behavior, vol. 28, no. 2, pp. 574-582.
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Chang, Z, Liu, W, Feng, J, Lin, Z, Shi, C, Wang, T, Lei, Y, Zhao, X, Song, J & Wang, G 2024, 'Cobalt/MXene‐derived TiO₂ Heterostructure as a Functional Separator Coating to Trap Polysulfide and Accelerate Redox Kinetics for Reliable Lithium‐sulfur Battery', Batteries & Supercaps, vol. 7, no. 4.
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AbstractLithium‐sulfur (Li−S) batteries are one of the most potential new energy storage systems due to their high theoretical capacity (1675 mAh g−1) and high energy density (2600 Wh kg−1). However, the application of Li−S batteries is currently restricted due to the dissolution of polysulfides in the electrolyte, which leads to the shuttle effect of lithium polysulfides (LiPSs). Here, we present a Co@MXene‐derived TiO2 heterostructure decorated on carbon sheets derived from folic acid (Co@M‐TiO2/C) as a functional separator coating to trap polysulfide and accelerate redox kinetics in Li−S batteries. The interconnected porous structure with good electrical conductivity of the heterostructure boasts rapid ion diffusion and efficient electron transfer within the battery. By attaching Co and MXene‐derived dual‐phased TiO2 to two‐dimensional carbon sheets, heterostructures are formed, ensuring complete exposure of the active sites. These heterostructures exhibit catalytic effects on LiPSs and excellent adsorption capabilities, effectively inhibiting the shuttle effect and accelerating the redox kinetics. Considering these advantages, the Li−S battery with the optimized Co@M‐TiO2/C modified separator demonstrates a high specific capacity of 1481.7 mAh g−1 at 0.2 C, superior rate performance of 855.5 mAh g−1 at 2 C, and excellent cycling performance under a high sulfur load of 4.4 mg cm−2.

Chen, J, Zhang, G, Xiao, J, Li, J, Xiao, Y, Zhang, D, Gao, H, Guo, X, Wang, G & Liu, H 2024, 'A Stress Self‐Adaptive Bimetallic Stellar Nanosphere for High‐Energy Sodium‐Ion Batteries', Advanced Functional Materials, vol. 34, no. 1.
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AbstractBimetallic composites exhibit great potential as anode materials in advanced energy storage systems owing to their inherent tunability, cost‐effectiveness, and simultaneous achievement of high specific capacity and low reaction potential. However, simple biphase mixing often fails to achieve satisfactory performance. Herein, an innovative stress self‐adaptive bimetallic stellar nanosphere (50–200 nm) wherein bismuth (Bi) is fabricated, as a core, is seamlessly encapsulated by a tin (Sn) sneath (Sn‐Bi@C). This well‐integrated stellar configuration with bimetallic nature embodies the synergy between Bi and Sn, offering fortified conductivity and heightened sodium ion diffusion kinetics. Moreover, through meticulous utilization of finite element analysis simulations, a homogeneous stress distribution within the Sn‐enveloped Bi, efficiently mitigating the structural strain raised from the insertion of Na+ ions, is uncovered. The corresponding electrode demonstrates remarkable cyclic stability, as it exhibits no capacity decay after 100 cycles at 0.1 A g−1. Furthermore, it achieves an impressive 86.9% capacity retention even after an extensive 2000 cycles. When employed in a Na3V2(PO4)3 ‖ Sn‐Bi@C full cell configuration, it demonstrates exceptional capacity retention of 97.06% after 300 cycles at 1 A g−1, along with a high energy density of 251.2 W h kg−1.

Chen, X, Yang, H, Gu, Y, Wen, C, Sun, Y, Ke, J & Feng, W 2024, 'Interparticle energy transfer between NaNdF4 and NaYbF4 in self-assembled nanostructures', Journal of Rare Earths, vol. 42, no. 6, pp. 1029-1035.
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Chen, Y, Huang, X, Chen, H & Yi, C 2024, 'An easy-to-perform method for microvessel isolation and primary brain endothelial cell culture to study Alzheimer’s Disease', Heliyon, pp. e33077-e33077.
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Chen, Y, Li, X-Y, Chen, Z, Ozden, A, Huang, JE, Ou, P, Dong, J, Zhang, J, Tian, C, Lee, B-H, Wang, X, Liu, S, Qu, Q, Wang, S, Xu, Y, Miao, RK, Zhao, Y, Liu, Y, Qiu, C, Abed, J, Liu, H, Shin, H, Wang, D, Li, Y, Sinton, D & Sargent, EH 2024, 'Efficient multicarbon formation in acidic CO2 reduction via tandem electrocatalysis', Nature Nanotechnology, vol. 19, no. 3, pp. 311-318.
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The electrochemical reduction of CO2 in acidic conditions enables high single-pass carbon efficiency. However, the competing hydrogen evolution reaction reduces selectivity in the electrochemical reduction of CO2, a reaction in which the formation of CO, and its ensuing coupling, are each essential to achieving multicarbon (C2+) product formation. These two reactions rely on distinct catalyst properties that are difficult to achieve in a single catalyst. Here we report decoupling the CO2-to-C2+ reaction into two steps, CO2-to-CO and CO-to-C2+, by deploying two distinct catalyst layers operating in tandem to achieve the desired transformation. The first catalyst, atomically dispersed cobalt phthalocyanine, reduces CO2 to CO with high selectivity. This process increases local CO availability to enhance the C-C coupling step implemented on the second catalyst layer, which is a Cu nanocatalyst with a Cu-ionomer interface. The optimized tandem electrodes achieve 61% C2H4 Faradaic efficiency and 82% C2+ Faradaic efficiency at 800 mA cm-2 at 25 °C. When optimized for single-pass utilization, the system reaches a single-pass carbon efficiency of 90 ± 3%, simultaneous with 55 ± 3% C2H4 Faradaic efficiency and a total C2+ Faradaic efficiency of 76 ± 2%, at 800 mA cm-2 with a CO2 flow rate of 2 ml min-1.

Chen, Y, Xu, L, Yang, X, Li, Q, Yao, M & Wang, G 2024, 'Nanocomposite design for solid-state lithium metal batteries: Progress, challenge, and prospects', Advanced Nanocomposites, vol. 1, no. 1, pp. 120-143.
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Chen, Z, Han, G-F, Mahmood, A, Hou, J, Wei, W, Kyong Shon, H, Wang, G, David Waite, T, Baek, J-B & Ni, B-J 2024, 'Mechanosynthesized electroactive materials for sustainable energy and environmental applications: A critical review', Progress in Materials Science, vol. 145, pp. 101299-101299.
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Choi, V, Park, SB, Lacey, J, Kumar, S, Heller, G & Grimison, P 2024, 'Electroacupuncture use for treatment of taxane-induced peripheral neuropathy in patients with breast cancer: protocol for a pilot, randomised, blinded, sham-controlled trial (EA for CIPN)', BMJ Open, vol. 14, no. 1, pp. e076391-e076391.
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IntroductionChemotherapy-induced peripheral neuropathy (CIPN) is a common dose-limiting side effect of neurotoxic chemotherapy. Acute symptoms of CIPN during treatment can lead to dose reduction and cessation. Trials using electroacupuncture (EA) to treat established CIPN postchemotherapy have shown some efficacy. The current trial aims to assess the feasibility and preliminary efficacy of using EA to treat CIPN during chemotherapy.Methods and analysisThe current study is a single-centre, 1:1 randomised, sham-controlled pilot study set in a tertiary cancer hospital in Sydney, Australia, and will recruit 40 adult patients with early breast cancer undergoing adjuvant or neoadjuvant paclitaxel chemotherapy. Patients who develop CIPN within the first 6 weeks of chemotherapy will receive either true EA or sham-EA once a week for 10 weeks. The coprimary endpoints are recruitment and adherence rate, successful blinding of patients and compliance with the follow-up period. Secondary endpoints are mean change of CIPN symptoms from randomisation to end of treatment, sustained change in CIPN symptoms at 8-week and 24-week follow-up postchemotherapy, proportion of subjects attaining completion of 12 weeks of chemotherapy without dose reduction or cessation, change in acupuncture expectancy response pretreatment, during treatment and posttreatment. The primary assessment tool for the secondary endpoints will be a validated patient-reported outcome measure (European Organisation for Research and Treatment of Cancer Quality of Life Chemotherapy-Induced Peripheral Neuropathy) captured weekly from randomisation to week 12 of chemotherapy.Ethics and disseminationThe study protocol (2021/ETH12123) has been approved by the institutional Human Research Ethics Committee at St Vincent’s Hospital Sydney and Chr...

Chowdhury, S, Sais, D, Donnelly, S & Tran, N 2024, 'The knowns and unknowns of helminth–host miRNA cross-kingdom communication', Trends in Parasitology, vol. 40, no. 2, pp. 176-191.
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Clark, K, Boland, JW & Currow, DC 2024, 'Letter to the Editor. A Response to: Palliative Management of Inoperable Malignant Bowel Obstruction: Prospective, Open Label, Phase 2 Study at an NCI Comprehensive Cancer Center.', Journal of pain and symptom management, vol. 67, no. 6, pp. e919-e920.
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Clover Ree, L, de la Hunty, M, Moret, S & Chadwick, S 2024, 'An investigation into the effect of surfactants on iron oxide powder suspension formulations for fingermark development', Forensic Science International, vol. 358, pp. 112019-112019.
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Cook, AM, Rezende, EL, Petrou, K & Leigh, A 2024, 'Beyond a single temperature threshold: Applying a cumulative thermal stress framework to plant heat tolerance', Ecology Letters, vol. 27, no. 3.
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AbstractMost plant thermal tolerance studies focus on single critical thresholds, which limit the capacity to generalise across studies and predict heat stress under natural conditions. In animals and microbes, thermal tolerance landscapes describe the more realistic, cumulative effects of temperature. We tested this in plants by measuring the decline in leaf photosynthetic efficiency (FV/FM) following a combination of temperatures and exposure times and then modelled these physiological indices alongside recorded environmental temperatures. We demonstrate that a general relationship between stressful temperatures and exposure durations can be effectively employed to quantify and compare heat tolerance within and across plant species and over time. Importantly, we show how FV/FM curves translate to plants under natural conditions, suggesting that environmental temperatures often impair photosynthetic function. Our findings provide more robust descriptors of heat tolerance in plants and suggest that heat tolerance in disparate groups of organisms can be studied with a single predictive framework.

Corletto, A, Fronzi, M, Joannidis, AK, Sherrell, PC, Ford, MJ, Winkler, DA, Shapter, JG, Bullock, J & Ellis, AV 2024, 'A Predictive Model for Monolayer‐Selective Metal‐Mediated MoS₂ Exfoliation Incorporating Electrostatics', Advanced Materials Interfaces, vol. 11, no. 2.
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AbstractThe metal‐mediated exfoliation (MME) method enables monolayer‐selective exfoliation of van der Waals (vdW) crystals, improving the efficacy of large monolayer production. Previous physical models explaining monolayer‐selective MME propose that the main contributors to monolayer‐selectivity are vdW crystal/metal surface binding energy and/or vdW crystal layer strain resulting from lattice mismatch. However, the performance of some metals for MME is inconsistent with these models. Here, a new model is proposed using MoS2 as a representative vdW crystal. The model explains how the MoS2/metal interface electrostatics, in combination with strain, determines monolayer‐selectivity of MME by modulating the MoS2 interlayer energy. Monolayer MoS2/metal interfaces are characterized using in situ Raman spectroscopy and density functional theory calculations to estimate the electrostatics and strain of MoS2 in contact with different metals. The model successfully demonstrates the dependence of MME monolayer‐selectivity on the MoS2/metal interface electrostatics and highlights the significance of electrostatics in nanomaterial vdW interactions.

Cotter, DJ, Severson, AL, Kang, JTL, Godrej, HN, Carmi, S & Rosenberg, NA 2024, 'Modeling the effects of consanguinity on autosomal and X-chromosomal runs of homozygosity and identity-by-descent sharing', G3: Genes, Genomes, Genetics, vol. 14, no. 2.
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Abstract Runs of homozygosity (ROH) and identity-by-descent (IBD) sharing can be studied in diploid coalescent models by noting that ROH and IBD-sharing at a genomic site are predicted to be inversely related to coalescence times—which in turn can be mathematically obtained in terms of parameters describing consanguinity rates. Comparing autosomal and X-chromosomal coalescent models, we consider ROH and IBD-sharing in relation to consanguinity that proceeds via multiple forms of first-cousin mating. We predict that across populations with different levels of consanguinity, (1) in a manner that is qualitatively parallel to the increase of autosomal IBD-sharing with autosomal ROH, X-chromosomal IBD-sharing increases with X-chromosomal ROH, owing to the dependence of both quantities on consanguinity levels; (2) even in the absence of consanguinity, X-chromosomal ROH and IBD-sharing levels exceed corresponding values for the autosomes, owing to the smaller population size and lower coalescence time for the X chromosome than for autosomes; (3) with matrilateral consanguinity, the relative increase in ROH and IBD-sharing on the X chromosome compared to the autosomes is greater than in the absence of consanguinity. Examining genome-wide SNPs in human populations for which consanguinity levels have been estimated, we find that autosomal and X-chromosomal ROH and IBD-sharing levels generally accord with the predictions. We find that each 1% increase in autosomal ROH is associated with an increase of 2.1% in X-chromosomal ROH, and each 1% increase in autosomal IBD-sharing is associated with an increase of 1.6% in X-chromosomal IBD-sharing. For each calculation, particularly for ROH, the estimate is reasonably close to the increase of 2% predicted by the population-size difference between autosomes and X chromosomes. The results support the utility of coalescent models for understanding patterns of genomic sharing an...

D’Amato, ME, Joly, Y, Lynch, V, Machado, H, Scudder, N & Zieger, M 2024, 'Ethical considerations for Forensic Genetic Frequency databases: First Report conception and development', Forensic Science International: Genetics, vol. 71, pp. 103053-103053.
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Dawson, BM, Ueland, M, Carter, DO, Mclntyre, D & Barton, PS 2024, 'Bridging the gap between decomposition theory and forensic research on postmortem interval', International Journal of Legal Medicine, vol. 138, no. 2, pp. 509-518.
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AbstractKnowledge of the decomposition of vertebrate animals has advanced considerably in recent years and revealed complex interactions among biological and environmental factors that affect rates of decay. Yet this complexity remains to be fully incorporated into research or models of the postmortem interval (PMI). We suggest there is both opportunity and a need to use recent advances in decomposition theory to guide forensic research and its applications to understanding the PMI. Here we synthesise knowledge of the biological and environmental factors driving variation in decomposition and the acknowledged limitations among current models of the PMI. To guide improvement in this area, we introduce a conceptual framework that highlights the multiple interdependencies affecting decay rates throughout the decomposition process. Our framework reinforces the need for a multidisciplinary approach to PMI research, and calls for an adaptive research cycle that aims to reduce uncertainty in PMI estimates via experimentation, modelling, and validation.

De Rubis, G, Chakraborty, A, Paudel, KR, Wang, C, Kannaujiya, V, Wich, PR, Hansbro, PM, Samuel, CS, Oliver, B & Dua, K 2024, 'Exploring the anti-inflammatory and anti-fibrotic activity of NFκB decoy oligodeoxynucleotide-loaded spermine-functionalized acetalated nanoparticles', Chemico-Biological Interactions, vol. 396, pp. 111059-111059.
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De Rubis, G, Paudel, KR, Allam, VSRR, Malyla, V, Subramaniyan, V, Singh, SK, Panth, N, Gupta, G, Hansbro, PM, Chellappan, DK & Dua, K 2024, 'Involvement of osteopontin, EpCAM, estrogen receptor-alpha, and carbonic anhydrase IX protein in managing lung cancer via Berberine-loaded liquid crystalline nanoparticles', Pathology - Research and Practice, vol. 253, pp. 154971-154971.
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De Rubis, G, Paudel, KR, Corrie, L, Mehndiratta, S, Patel, VK, Kumbhar, PS, Manjappa, AS, Disouza, J, Patravale, V, Gupta, G, Manandhar, B, Rajput, R, Robinson, AK, Reyes, R-J, Chakraborty, A, Chellappan, DK, Singh, SK, Oliver, BGG, Hansbro, PM & Dua, K 2024, 'Applications and advancements of nanoparticle-based drug delivery in alleviating lung cancer and chronic obstructive pulmonary disease', Naunyn-Schmiedeberg's Archives of Pharmacology, vol. 397, no. 5, pp. 2793-2833.
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Lung cancer (LC) and chronic obstructive pulmonary disease (COPD) are among the leading causes of mortality worldwide. Cigarette smoking is among the main aetiologic factors for both ailments. These diseases share common pathogenetic mechanisms including inflammation, oxidative stress, and tissue remodelling. Current therapeutic approaches are limited by low efficacy and adverse effects. Consequentially, LC has a 5-year survival of < 20%, while COPD is incurable, underlining the necessity for innovative treatment strategies. Two promising emerging classes of therapy against these diseases include plant-derived molecules (phytoceuticals) and nucleic acid-based therapies. The clinical application of both is limited by issues including poor solubility, poor permeability, and, in the case of nucleic acids, susceptibility to enzymatic degradation, large size, and electrostatic charge density. Nanoparticle-based advanced drug delivery systems are currently being explored as flexible systems allowing to overcome these limitations. In this review, an updated summary of the most recent studies using nanoparticle-based advanced drug delivery systems to improve the delivery of nucleic acids and phytoceuticals for the treatment of LC and COPD is provided. This review highlights the enormous relevance of these delivery systems as tools that are set to facilitate the clinical application of novel categories of therapeutics with poor pharmacokinetic properties. This picture was generated with BioRender.

De Rubis, G, Paudel, KR, Vishwas, S, Kokkinis, S, Chellappan, DK, Gupta, G, MacLoughlin, R, Gulati, M, Singh, SK & Dua, K 2024, 'Fecal microbiome extract downregulates the expression of key proteins at the interface between airway remodelling and lung cancer pathogenesis in vitro', Pathology - Research and Practice, vol. 260, pp. 155387-155387.
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De Rubis, G, Paudel, KR, Yeung, S, Agarwal, V, Hansbro, PM, Oliver, BGG & Dua, K 2024, 'Ribavirin attenuates carcinogenesis by downregulating IL-6 and IL-8 in vitro in human lung adenocarcinoma', Pathology - Research and Practice, vol. 253, pp. 155038-155038.
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De Rubis, G, Paudel, KR, Yeung, S, Mohamad, S, Sudhakar, S, Singh, SK, Gupta, G, Hansbro, PM, Chellappan, DK, Oliver, BGG & Dua, K 2024, '18-β-glycyrrhetinic acid-loaded polymeric nanoparticles attenuate cigarette smoke-induced markers of impaired antiviral response in vitro', Pathology - Research and Practice, vol. 257, pp. 155295-155295.
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Denis, V, Ferrier‐Pagès, C, Schubert, N, Coppari, M, Baker, DM, Camp, EF, Gori, A, Grottoli, AG, Houlbrèque, F, Maier, SR, Mancinelli, G, Martinez, S, Yalçın Özdilek, Ş, Radice, VZ, Ribes, M, Richter, C, Viladrich, N & Rossi, S 2024, 'Heterotrophy in marine animal forests in an era of climate change', Biological Reviews, vol. 99, no. 3, pp. 965-978.
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ABSTRACTMarine animal forests (MAFs) are benthic ecosystems characterised by biogenic three‐dimensional structures formed by suspension feeders such as corals, gorgonians, sponges and bivalves. They comprise highly diversified communities among the most productive in the world's oceans. However, MAFs are in decline due to global and local stressors that threaten the survival and growth of their foundational species and associated biodiversity. Innovative and scalable interventions are needed to address the degradation of MAFs and increase their resilience under global change. Surprisingly, few studies have considered trophic interactions and heterotrophic feeding of MAF suspension feeders as an integral component of MAF conservation. Yet, trophic interactions are important for nutrient cycling, energy flow within the food web, biodiversity, carbon sequestration, and MAF stability. This comprehensive review describes trophic interactions at all levels of ecological organisation in tropical, temperate, and cold‐water MAFs. It examines the strengths and weaknesses of available tools for estimating the heterotrophic capacities of the foundational species in MAFs. It then discusses the threats that climate change poses to heterotrophic processes. Finally, it presents strategies for improving trophic interactions and heterotrophy, which can help to maintain the health and resilience of MAFs.

Dilernia, NJ, Woodcock, S, Camp, EF, Hughes, DJ, Kühl, M & Suggett, DJ 2024, 'Intra‐colony spatial variance of oxyregulation and hypoxic thresholds for key Acropora coral species', Ecology and Evolution, vol. 14, no. 3, p. e11100.
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AbstractOxygen (O2) availability is essential for healthy coral reef functioning, yet how continued loss of dissolved O2 via ocean deoxygenation impacts performance of reef building corals remains unclear. Here, we examine how intra‐colony spatial geometry of important Great Barrier Reef (GBR) coral species Acropora may influence variation in hypoxic thresholds for upregulation, to better understand capacity to tolerate future reductions in O2 availability. We first evaluate the application of more streamlined models used to parameterise Hypoxia Response Curve data, models that have been used historically to identify variable oxyregulatory capacity. Using closed‐system respirometry to analyse O2 drawdown rate, we show that a two‐parameter model returns similar outputs as previous 12th‐order models for descriptive statistics such as the average oxyregulation capacity (Tpos) and the ambient O2 level at which the coral exerts maximum regulation effort (Pcmax), for diverse Acropora species. Following an experiment to evaluate whether stress induced by coral fragmentation for respirometry affected O2 drawdown rate, we subsequently identify differences in hypoxic response for the interior and exterior colony locations for the species Acropora abrotanoides, Acropora cf. microphthalma and Acropora elseyi. Average regulation capacity across species was greater (0.78–1.03 ± SE 0.08) at the colony interior compared with exterior (0.60–0.85 ± SE 0.08). Moreover, Pcmax occurred at relatively low pO2 of <30% (±1.24; SE) air saturation for a...

Ding, L, Chen, C, Shan, X, Liu, B, Wang, D, Du, Z, Zhao, G, Su, QP, Yang, Y, Halkon, B, Tran, TT, Liao, J, Aharonovich, I, Zhang, M, Cheng, F, Fu, L, Xu, X & Wang, F 2024, 'Optical Nonlinearity Enabled Super‐Resolved Multiplexing Microscopy', Advanced Materials, vol. 36, no. 2.
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AbstractOptical multiplexing for nanoscale object recognition is of great significance within the intricate domains of biology, medicine, anti‐counterfeiting, and microscopic imaging. Traditionally, the multiplexing dimensions of nanoscopy are limited to emission intensity, color, lifetime, and polarization. Here, a novel dimension, optical nonlinearity, is proposed for super‐resolved multiplexing microscopy. This optical nonlinearity is attributable to the energy transitions between multiple energy levels of the doped lanthanide ions in upconversion nanoparticles (UCNPs), resulting in unique optical fingerprints for UCNPs with different compositions. A vortex beam is applied to transport the optical nonlinearity onto the imaging point‐spread function (PSF), creating a robust super‐resolved multiplexing imaging strategy for differentiating UCNPs with distinctive optical nonlinearities. The composition information of the nanoparticles can be retrieved with variations of the corresponding PSF in the obtained image. Four channels multiplexing super‐resolved imaging with a single scanning, applying emission color and nonlinearity of two orthogonal imaging dimensions with a spatial resolution higher than 150 nm (1/6.5λ), are demonstrated. This work provides a new and orthogonal dimension – optical nonlinearity – to existing multiplexing dimensions, which shows great potential in bioimaging, anti‐counterfeiting, microarray assays, deep tissue multiplexing detection, and high‐density data storage.

Ding, L, Chen, C, Shan, X, Liu, B, Wang, D, Du, Z, Zhao, G, Su, QP, Yang, Y, Halkon, B, Tran, TT, Liao, J, Aharonovich, I, Zhang, M, Cheng, F, Fu, L, Xu, X & Wang, F 2024, 'Optical Nonlinearity Enabled Super‐Resolved Multiplexing Microscopy (Adv. Mater. 2/2024)', Advanced Materials, vol. 36, no. 2.
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Donovan, C, Thorpe, AE, Gomez, HM, Carroll, OR, Feng, M, Bai, X, Chen, H, Horvat, JC, Oliver, BGG & Kim, RY 2024, 'The GPR84 Antagonist GLPG1205 Reduces Features of Disease in Experimental Severe Asthma', American Journal of Respiratory Cell and Molecular Biology, vol. 70, no. 5, pp. 424-427.
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Dooley, AH 2024, 'Gavin Brown: 1942–2010', Historical Records of Australian Science.
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Duncan, RJ, Nielsen, D, Søreide, JE, Varpe, Ø, Tobin, MJ, Pitusi, V, Heraud, P & Petrou, K 2024, 'Biomolecular profiles of Arctic sea-ice diatoms highlight the role of under-ice light in cellular energy allocation', ISME Communications, vol. 4, no. 1.
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Abstract Arctic sea-ice diatoms fuel polar marine food webs as they emerge from winter darkness into spring. Through their photosynthetic activity they manufacture the nutrients and energy that underpin secondary production. Sea-ice diatom abundance and biomolecular composition vary in space and time. With climate change causing short-term extremes and long-term shifts in environmental conditions, understanding how and in what way diatoms adjust biomolecular stores with environmental perturbation is important to gain insight into future ecosystem energy production and nutrient transfer. Using synchrotron-based Fourier transform infrared microspectroscopy, we examined the biomolecular composition of five dominant sea-ice diatom taxa from landfast ice communities covering a range of under-ice light conditions during spring, in Svalbard, Norway. In all five taxa, we saw a doubling of lipid and fatty acid content when light transmitted to the ice–water interface was &gt;5% but &lt;15% (85%–95% attenuation through snow and ice). We determined a threshold around 15% light transmittance after which biomolecular synthesis plateaued, likely because of photoinhibitory effects, except for Navicula spp., which continued to accumulate lipids. Increasing under-ice light availability led to increased energy allocation towards carbohydrates, but this was secondary to lipid synthesis, whereas protein content remained stable. It is predicted that under-ice light availability will change in the Arctic, increasing because of sea-ice thinning and potentially decreasing with higher snowfall. Our findings show that the nutritional content of sea-ice diatoms is taxon-specific and linked to these changes, highlighting potential implications for future energy and nutrient supply for the polar marine food web.

Duncan, RJ, Søreide, JE, Varpe, Ø, Wiktor, J, Pitusi, V, Runge, E & Petrou, K 2024, 'Spatio-temporal dynamics in microalgal communities in Arctic land-fast sea ice', Progress in Oceanography, vol. 224, pp. 103248-103248.
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Ellis, JT & Stothard, JR 2024, 'Celebrating 150 volumes of Parasitology with an outlook towards 2030 production', Parasitology, vol. 151, no. 3, pp. 247-250.
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Espinoza-Corral, R, Iwai, M, Zavřel, T, Lechno-Yossef, S, Sutter, M, Červený, J, Niyogi, KK & Kerfeld, CA 2024, 'Phycobilisome protein ApcG interacts with PSII and regulates energy transfer in Synechocystis', Plant Physiology, vol. 194, no. 3, pp. 1383-1396.
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Abstract Photosynthetic organisms harvest light using pigment–protein complexes. In cyanobacteria, these are water-soluble antennae known as phycobilisomes (PBSs). The light absorbed by PBS is transferred to the photosystems in the thylakoid membrane to drive photosynthesis. The energy transfer between these complexes implies that protein–protein interactions allow the association of PBS with the photosystems. However, the specific proteins involved in the interaction of PBS with the photosystems are not fully characterized. Here, we show in Synechocystis sp. PCC 6803 that the recently discovered PBS linker protein ApcG (sll1873) interacts specifically with PSII through its N-terminal region. Growth of cyanobacteria is impaired in apcG deletion strains under light-limiting conditions. Furthermore, complementation of these strains using a phospho-mimicking version of ApcG causes reduced growth under normal growth conditions. Interestingly, the interaction of ApcG with PSII is affected when a phospho-mimicking version of ApcG is used, targeting the positively charged residues interacting with the thylakoid membrane, suggesting a regulatory role mediated by phosphorylation of ApcG. Low-temperature fluorescence measurements showed decreased PSI fluorescence in apcG deletion and complementation strains. The PSI fluorescence was the lowest in the phospho-mimicking complementation strain, while the pull-down experiment showed no interaction of ApcG with PSI under any tested condition. Our results highlight the importance of ApcG for selectively directing energy harvested by the PBS and imply that the phosphorylation status of ApcG plays a role in regulating energy transfer from PSII to PSI.

Faiz, A, Wiersma, VR, Salzbrunn, JB, Brandsma, C-A, Timens, W, Burgess, JK, van den Berge, M, Slebos, D-J, Guryev, V & Pouwels, SD 2024, 'COPD Patients Display Increased Peripheral Blood Somatic Mutations Which Associate With the Prevalence of Co-morbidities', Archivos de Bronconeumología, vol. 60, no. 2, pp. 119-121.
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Feary, DA, Fowler, AM & Booth, DJ 2024, 'Predator-avoidance behaviour of target and non-target temperate reef fishes is lower in areas protected from fishing', Marine Biology, vol. 171, no. 3.
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AbstractThe effects of hunting on predator-avoidance behaviour are increasingly being recognised on land but have received less attention in marine systems. We examined whether predator-avoidance behaviour of temperate reef fishes differed between areas protected and not protected from recreational fishing by examining the flight-initiation distance (FID; the distance a predator can approach before the prey animal flees) of six common species in southeastern Australia. By testing species that ranged in desirability to recreational fishers, we could determine if behavioural differences were specific to target species or extended more broadly throughout the assemblage. After accounting for potential variability among sites within protection levels, we found that the FID of all species was higher in fished areas than protected areas, with FID up to 2.4 times higher in fished areas. The two commonly targeted species had the greatest FID response to fishing. FID also increased with body size for all but one species. Our findings indicate the potential for assemblage-wide effects of fishing on predator-avoidance behaviour and are consistent with an indirect mechanism of behavioural modification.

Ferrari, AJ, Santomauro, DF, Aali, A, Abate, YH, Abbafati, C, Abbastabar, H, Abd ElHafeez, S, Abdelmasseh, M, Abd-Elsalam, S, Abdollahi, A, Abdullahi, A, Abegaz, KH, Abeldaño Zuñiga, RA, Aboagye, RG, Abolhassani, H, Abreu, LG, Abualruz, H, Abu-Gharbieh, E, Abu-Rmeileh, NME, Ackerman, IN, Addo, IY, Addolorato, G, Adebiyi, AO, Adepoju, AV, Adewuyi, HO, Afyouni, S, Afzal, S, Afzal, S, Agodi, A, Ahmad, A, Ahmad, D, Ahmad, F, Ahmad, S, Ahmed, A, Ahmed, LA, Ahmed, MB, Ajami, M, Akinosoglou, K, Akkaif, MA, Al Hasan, SM, Alalalmeh, SO, Al-Aly, Z, Albashtawy, M, Aldridge, RW, Alemu, MD, Alemu, YM, Alene, KA, Al-Gheethi, AAS, Alharrasi, M, Alhassan, RK, Ali, MU, Ali, R, Ali, SSS, Alif, SM, Aljunid, SM, Al-Marwani, S, Almazan, JU, Alomari, MA, Al-Omari, B, Altaany, Z, Alvis-Guzman, N, Alvis-Zakzuk, NJ, Alwafi, H, Al-Wardat, MS, Al-Worafi, YM, Aly, S, Alzoubi, KH, Amare, AT, Amegbor, PM, Ameyaw, EK, Amin, TT, Amindarolzarbi, A, Amiri, S, Amugsi, DA, Ancuceanu, R, Anderlini, D, Anderson, DB, Andrade, PP, Andrei, CL, Ansari, H, Antony, CM, Anwar, S, Anwar, SL, Anwer, R, Anyanwu, PE, Arab, JP, Arabloo, J, Arafat, M, Araki, DT, Aravkin, AY, Arkew, M, Armocida, B, Arndt, MB, Arooj, M, Artamonov, AA, Aruleba, RT, Arumugam, A, Ashbaugh, C, Ashemo, MY, Ashraf, M, Asika, MO, Askari, E, Astell-Burt, T, Athari, SS, Atorkey, P, Atout, MMW, Atreya, A, Aujayeb, A, Ausloos, M, Avan, A, Awotidebe, AW, Awuviry-Newton, K, Ayala Quintanilla, BP, Ayuso-Mateos, JL, Azadnajafabad, S, Azevedo, RMS, Babu, AS, Badar, M, Badiye, AD, Baghdadi, S, Bagheri, N, Bah, S, Bai, R, Baker, JL, Bakkannavar, SM, Bako, AT, Balakrishnan, S, Bam, K, Banik, PC, Barchitta, M, Bardhan, M, Bardideh, E, Barker-Collo, SL, Barqawi, HJ, Barrow, A, Barteit, S, Barua, L, Bashiri Aliabadi, S, Basiru, A, Basu, S, Basu, S, Bathini, PP, Batra, K, Baune, BT, Bayileyegn, NS, Behnam, B, Behnoush, AH, Beiranvand, M, Bejarano Ramirez, DF, Bell, ML, Bello, OO, Beloukas, A, Bensenor, IM, Berezvai, Z, Bernabe, E, Bernstein, RS, Bettencourt, PJG, Bhagavathula, AS, Bhala, N, Bhandari, D, Bhargava, A, Bhaskar, S, Bhat, V, Bhatti, GK, Bhatti, JS, Bhatti, MS, Bhatti, R, Bhutta, ZA, Bikbov, B, Bishai, JD, Bisignano, C, Bitra, VR, Bjørge, T, Bodolica, V, Bodunrin, AO, Bogale, EK, Bonakdar Hashemi, M, Bonny, A, Bora Basara, B, Borhany, H, Boxe, C, Brady, OJ, Bragazzi, NL, Braithwaite, D, Brant, LC & et al. 2024, 'Global incidence, prevalence, years lived with disability (YLDs), disability-adjusted life-years (DALYs), and healthy life expectancy (HALE) for 371 diseases and injuries in 204 countries and territories and 811 subnational locations, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021', The Lancet, vol. 403, no. 10440, pp. 2133-2161.
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Fitschen, LJ, Newing, TP, Johnston, NP, Bell, CE & Tolun, G 2024, 'Half a century after their discovery: Structural insights into exonuclease and annealase proteins catalyzing recombineering', Engineering Microbiology, vol. 4, no. 1, pp. 100120-100120.
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Freedman, LS, Wang, C-Y, Commins, J, Barrett, B, Midthune, D, Dodd, KW, Carroll, RJ & Kipnis, V 2024, 'Can sodium and potassium measured in timed voids be used as reference instruments for validating self-report instruments? Results from a urine calibration study', The American Journal of Clinical Nutrition, vol. 119, no. 5, pp. 1321-1328.
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Fursman, H, Finch, E, Xiao, L, Lefrançois, E, Gupta, A, Bartlett, M, Latimer, J, Chadwick, S, Roux, C & Morelato, M 2024, 'A snapshot of injecting drug consumption from the analysis of used syringes within the Medically Supervised Injecting Centre in Sydney, Australia', Drug and Alcohol Review, vol. 43, no. 3, pp. 787-798.
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AbstractIntroductionThe administration of illicit drugs by injection is associated with considerable harm, including an increased risk of overdose. The chemical analysis of used syringes can enhance knowledge on injecting drug consumption beyond traditional data sources (self‐report surveys). This additional information may be useful during significant global events like the COVID‐19 pandemic. This study aimed to examine a snapshot of the drugs injected at the Medically Supervised Injecting Centre (MSIC) in Sydney, Australia, in 2019–2020.MethodsUsed syringes were collected from MSIC across three periods throughout 2019 and 2020 (February 2019, March—April 2020 and June—September 2020). Drug residues were extracted from used syringes using methanol before detection by gas chromatography—mass spectrometry and ultra‐performance liquid chromatography—tandem mass spectrometry. The chemical analysis results were compared to self‐report data obtained from MSIC clients.ResultsHeroin (46–53%), methamphetamine (24–34%) and pharmaceutical opioids (15–27%) were the most common drug residues detected. The chemically detected drugs had declining coherence with the drugs self‐reported by MSIC clients across the time periods examined.Discussion and ConclusionsThere was no significant change in the drugs injected (heroin, methamphetamine and pharmaceutical opioids) across the three periods collected throughout varying COVID‐19 lockdown restrictions. Changes in the frequency of other drugs injected and discrepancies between chemical analysis and self‐report were potentially related to regulatory changes, degradation or misinformed sales. Routine chemical analysis of used syringes has provided an alternative informatio...

Gadhave, DG, Sugandhi, VV, Jha, SK, Nangare, SN, Gupta, G, Singh, SK, Dua, K, Cho, H, Hansbro, PM & Paudel, KR 2024, 'Neurodegenerative disorders: Mechanisms of degeneration and therapeutic approaches with their clinical relevance', Ageing Research Reviews, vol. 99, pp. 102357-102357.
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Gangavarapu, K, Ji, X, Baele, G, Fourment, M, Lemey, P, Matsen, FA & Suchard, MA 2024, 'Many-core algorithms for high-dimensional gradients on phylogenetic trees', Bioinformatics, vol. 40, no. 2.
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Abstract Motivation Advancements in high-throughput genomic sequencing are delivering genomic pathogen data at an unprecedented rate, positioning statistical phylogenetics as a critical tool to monitor infectious diseases globally. This rapid growth spurs the need for efficient inference techniques, such as Hamiltonian Monte Carlo (HMC) in a Bayesian framework, to estimate parameters of these phylogenetic models where the dimensions of the parameters increase with the number of sequences N. HMC requires repeated calculation of the gradient of the data log-likelihood with respect to (wrt) all branch-length-specific (BLS) parameters that traditionally takes O(N2) operations using the standard pruning algorithm. A recent study proposes an approach to calculate this gradient in O(N), enabling researchers to take advantage of gradient-based samplers such as HMC. The CPU implementation of this approach makes the calculation of the gradient computationally tractable for nucleotide-based models but falls short in performance for larger state-space size models, such as Markov-modulated and codon models. Here, we describe novel massively parallel algorithms to calculate the gradient of the log-likelihood wrt all BLS parameters that take advantage of graphics processing units (GPUs) and result in many fold higher speedups over previous CPU implementations. Results We benchmark these GPU algorithms on three computing systems using three evolutionary inference examples exploring complete genomes from 997 dengue viruses, 62 carnivore mitochondria and 49 yeasts, and observe a &gt;128-fold speedup over the CPU implementation for codon-based models and &gt;8-fold speedup for nucleotide-based models. As a practical d...

Ganio, K, Nasreen, M, Yang, Z, Maunders, EA, Luo, Z, Hossain, SI, Ngu, DHY, Ellis, D, Gu, J, Neville, SL, Wilksch, J, Gunn, AP, Whittall, JJ, Kobe, B, Deplazes, E, Kappler, U & McDevitt, CA 2024, 'Hfe Permease and Haemophilus influenzae Manganese Homeostasis', ACS Infectious Diseases, vol. 10, no. 2, pp. 436-452.
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Gao, H, Li, J, Zhang, F, Li, C, Xiao, J, Nie, X, Zhang, G, Xiao, Y, Zhang, D, Guo, X, Wang, Y, Kang, Y, Wang, G & Liu, H 2024, 'Revealing the Potential and Challenges of High‐Entropy Layered Cathodes for Sodium‐Based Energy Storage', Advanced Energy Materials, vol. 14, no. 20.
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AbstractSodium‐ion batteries (SIBs) reflect a strategic move for scalable and sustainable energy storage. The focus on high‐entropy (HE) cathode materials, particularly layered oxides, has ignited scientific interest due to the unique characteristics and effects to tackle their shortcomings, such as inferior structural stability, sluggish reaction kinetics, severe Jahn‐Teller effects induced lattice distortion, and poor oxygen reversibility at high voltage. This review focuses on high‐entropy oxide materials, highlighting their fundamentals, design principles, and application in layered oxide cathodes for SIBs. It delves into the growth mechanism, composition‐properties correlations, and the functional roles of high‐entropy design in enhancing the performance of layered oxide cathodes. Furthermore, it furnishes a comprehensive survey of recent advancements and persisting challenges within the domain of layered high‐entropy cathode materials, as well as offers insights into potential future research directions in line with the current state of knowledge.

Gill, RL, Fleck, R, Chau, K, Westerhausen, MT, Lockwood, TE, Violi, JP, Irga, PJ, Doblin, MA & Torpy, FR 2024, 'Fine particle pollution during megafires contains potentially toxic elements', Environmental Pollution, vol. 344, pp. 123306-123306.
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Gomez, HM, Haw, TJ, Ilic, D, Robinson, P, Donovan, C, Croft, AJ, Vanka, KS, Small, E, Carroll, OR, Kim, RY, Mayall, JR, Beyene, T, Palanisami, T, Ngo, DTM, Zosky, GR, Holliday, EG, Jensen, ME, McDonald, VM, Murphy, VE, Gibson, PG & Horvat, JC 2024, 'Landscape fire smoke airway exposure impairs respiratory and cardiac function and worsens experimental asthma', Journal of Allergy and Clinical Immunology.
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Gonzalez de Vega, R, Clases, D, Cunningham, BA, Ganio, K, Neville, SL, McDevitt, CA & Doble, PA 2024, 'Spatial distribution of trace metals and associated transport proteins during bacterial infection', Analytical and Bioanalytical Chemistry, vol. 416, no. 11, pp. 2783-2796.
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Innate immune systems alter the concentrations of trace elements in host niches in response to invading pathogens during infection. This work reports the interplay between d-block metal ions and their associated biomolecules using hyphenated elemental techniques to spatially quantify both elemental distributions and the abundance of specific transport proteins. Here, lung tissues were collected for analyses from naïve and Streptococcus pneumoniae-infected mice fed on a zinc-restricted or zinc-supplemented diet. Spatiotemporal distributions of manganese (55Mn), iron (56Fe), copper (63Cu), and zinc (66Zn) were determined by quantitative laser ablation-inductively coupled plasma-mass spectrometry. The murine transport proteins ZIP8 and ZIP14, which are associated with zinc transport, were also imaged by incorporation of immunohistochemistry techniques into the analytical workflow. Collectively, this work demonstrates the potential of a single instrumental platform suitable for multiplex analyses of tissues and labelled antibodies to investigate complex elemental interactions at the host-pathogen interface. Further, these methods have the potential for broad application to investigations of biological pathways where concomitant measurement of elements and biomolecules is crucial to understand the basis of disease and aid in development of new therapeutic approaches.

Gulati, N, Chellappan, DK, MacLoughlin, R, Gupta, G, Singh, SK, Oliver, BG, Dua, K & Dureja, H 2024, 'Advances in nano-based drug delivery systems for the management of cytokine influx-mediated inflammation in lung diseases', Naunyn-Schmiedeberg's Archives of Pharmacology, vol. 397, no. 6, pp. 3695-3707.
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Gunawan, C, Fleming, C, Irga, PJ, Jien Wong, R, Amal, R, Torpy, FR, Mojtaba Golzan, S & McGrath, KC 2024, 'Neurodegenerative effects of air pollutant Particles: Biological mechanisms implicated for Early-Onset Alzheimer’s disease', Environment International, vol. 185, pp. 108512-108512.
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Haider, AA, Zhao, H, Zi, Y, Xu, Z, Bai, X, Cun, Y, Liu, Y, Babeker, H, Saeed, A, Song, Z, Qiu, J, Huang, A, Liao, J & Yang, Z 2024, 'Advances in Reversible Luminescence Modification and Applications of Inorganic Phosphors Based on Chromism Reaction', Advanced Optical Materials, vol. 12, no. 5.
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AbstractThe reversible luminescence modification of inorganic phosphors has emerged as a promising field, enabling innovative applications such as optical memory, multiple anti‐counterfeiting, and photoswitches. Traditional luminescence modulation techniques, such as core–shell structure design and energy transfer‐related luminescent ions regulation, face challenges in achieving reversible luminescence modification. Chromism induces reversible color changes in materials when stimulated by external fields such as electricity, heat, and light. Combining chromism with luminescence enables the creation of chromism‐driven reversible luminescence manipulation in a single material. This review summarizes recent advances in reversible luminescence modification of inorganic phosphors based on chromism reaction and highlights their potential applications in optical data storage, fingerprint acquisition, and anti‐counterfeiting areas. The potential prospective research directions are also discussed and the challenges and opportunities of chromism‐based reversible luminescent materials are presented for further extended applications.

Hall, LM, Munasinghe, VS, Vella, NGF, Ellis, JT & Stark, D 2024, 'Observations on the transmission of Dientamoeba fragilis and the cyst life cycle stage', Parasitology, vol. 151, no. 3, pp. 337-345.
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AbstractLittle is known about the life cycle and mode of transmission of Dientamoeba fragilis. Recently it was suggested that fecal–oral transmission of cysts may play a role in the transmission of D. fragilis. In order to establish an infection, D. fragilis is required to remain viable when exposed to the pH of the stomach. In this study, we investigated the ability of cultured trophozoites to withstand the extremes of pH. We provide evidence that trophozoites of D. fragilis are vulnerable to highly acidic conditions. We also investigated further the ultrastructure of D. fragilis cysts obtained from mice and rats by transmission electron microscopy. These studies of cysts showed a clear cyst wall surrounding an encysted parasite. The cyst wall was double layered with an outer fibrillar layer and an inner layer enclosing the parasite. Hydrogenosomes, endoplasmic reticulum and nuclei were present in the cysts. Pelta-axostyle structures, costa and axonemes were identifiable and internal flagellar axonemes were present. This study therefore provides additional novel details and knowledge of the ultrastructure of the cyst stage of D. fragilis.

Harris, RJ, Alvarez, PR, Bryant, C, Briceño, VF, Cook, AM, Leigh, A & Nicotra, AB 2024, 'Acclimation of thermal tolerance in juvenile plants from three biomes is suppressed when extremes co-occur', Conservation Physiology, vol. 12, no. 1.
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Abstract Given the rising frequency of thermal extremes (heatwaves and cold snaps) due to climate change, comprehending how a plant’s origin affects its thermal tolerance breadth (TTB) becomes vital. We studied juvenile plants from three biomes: temperate coastal rainforest, desert and alpine. In controlled settings, plants underwent hot days and cold nights in a factorial design to examine thermal tolerance acclimation. We assessed thermal thresholds (Tcrit-hot and Tcrit-cold) and TTB. We hypothesized that (i) desert species would show the highest heat tolerance, alpine species the greatest cold tolerance and temperate species intermediate tolerance; (ii) all species would increase heat tolerance after hot days and cold tolerance after cold nights; (iii) combined exposure would broaden TTB more than individual conditions, especially in desert and alpine species. We found that biome responses were minor compared to the responses to the extreme temperature treatments. All plants increased thermal tolerance in response to hot 40°C days (Tcrit-hot increased by ~3.5°C), but there was minimal change in Tcrit-cold in response to the cold −2°C nights. In contrast, when exposed to both hot days and cold nights, on average, plants exhibited an antagonistic response in TTB, where cold tolerance decreased and heat tolerance was reduced, and so we did not see the bi-directional expansion we hypothesized. There was, however, considerable variation among species in these responses. As climate change intensifies, plant communities, especially in transitional seasons, will regularly face such temperature swings. Our results shed light on potential plant responses under these extremes, emphasizing the need for deeper species-specific thermal acclimation insights, ultimately guiding conservation efforts.

He, LX, Deng, K, Wang, J, Zhang, X, Wang, L, Zhang, HP, Xie, M, Chen, ZH, Zhang, J, Chen-Yu Hsu, A, Zhang, L, Oliver, BG, Wark, PAB, Qin, L, Gao, P, Wan, HJ, Liu, D, Luo, FM, Li, WM, Wang, G & Gibson, PG 2024, 'Clinical Subtypes of Neutrophilic Asthma: A Cluster Analysis From Australasian Severe Asthma Network', The Journal of Allergy and Clinical Immunology: In Practice, vol. 12, no. 3, pp. 686-698.e8.
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He, Q, Liu, DL, Wang, B, Wang, Z, Cowie, A, Simmons, A, Xu, Z, Li, L, Shi, Y, Liu, K, Harrison, MT, Waters, C, Huete, A & Yu, Q 2024, 'A food-energy-water-carbon nexus framework informs region-specific optimal strategies for agricultural sustainability', Resources, Conservation and Recycling, vol. 203, pp. 107428-107428.
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Hem, S, Cummins, ML, Wyrsch, ER, Drigo, B, Hoye, BJ, Maute, K, Sanderson-Smith, M, Gorman, J, Bogema, DR, Jenkins, C, Deutscher, AT, Yam, J, Hai, F, Donner, E, Jarocki, VM & Djordjevic, SP 2024, 'Genomic analysis of Citrobacter from Australian wastewater and silver gulls reveals novel sequence types carrying critically important antibiotic resistance genes', Science of The Total Environment, vol. 909, pp. 168608-168608.
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Hilton, JBW, Kysenius, K, Liddell, JR, Mercer, SW, Hare, DJ, Buncic, G, Paul, B, Wang, Y, Murray, SS, Kilpatrick, TJ, White, AR, Donnelly, PS & Crouch, PJ 2024, 'Evidence for decreased copper associated with demyelination in the corpus callosum of cuprizone-treated mice', Metallomics, vol. 16, no. 1.
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Abstract Demyelination within the central nervous system (CNS) is a significant feature of debilitating neurological diseases such as multiple sclerosis and administering the copper-selective chelatorcuprizone to mice is widely used to model demyelination in vivo. Conspicuous demyelination within the corpus callosum is generally attributed to cuprizone's ability to restrict copper availability in this vulnerable brain region. However, the small number of studies that have assessed copper in brain tissue from cuprizone-treated mice have produced seemingly conflicting outcomes, leaving the role of CNS copper availability in demyelination unresolved. Herein we describe our assessment of copper concentrations in brain samples from mice treated with cuprizone for 40 d. Importantly, we applied an inductively coupled plasma mass spectrometry methodology that enabled assessment of copper partitioned into soluble and insoluble fractions within distinct brain regions, including the corpus callosum. Our results show that cuprizone-induced demyelination in the corpus callosum was associated with decreased soluble copper in this brain region. Insoluble copper in the corpus callosum was unaffected, as were pools of soluble and insoluble copper in other brain regions. Treatment with the blood–brain barrier permeant copper compound CuII(atsm) increased brain copper levels and this was most pronounced in the soluble fraction of the corpus callosum. This effect was associated with significant mitigation of cuprizone-induced demyelination. These results provide support for the involvement of decreased CNS copper availability in demyelination in the cuprizone model. Relevance to human demyelinating disease is discussed.

Hinners, J, Argyle, PA, Walworth, NG, Doblin, MA, Levine, NM & Collins, S 2024, 'Multi-trait diversification in marine diatoms in constant and warmed environments', Proceedings of the Royal Society B: Biological Sciences, vol. 291, no. 2019, p. 20232564.
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Phytoplankton are photosynthetic marine microbes that affect food webs, nutrient cycles and climate regulation. Their roles are determined by correlated phytoplankton functional traits including cell size, chlorophyll content and cellular composition. Here, we explore patterns of evolution in interrelated trait values and correlations. Because both chance events and natural selection contribute to phytoplankton trait evolution, we used population bottlenecks to diversify six genotypes of Thalassiosirid diatoms. We then evolved them as large populations in two environments. Interspecific variation and within-species evolution were visualized for nine traits and their correlations using reduced axes (a trait-scape). Our main findings are that shifts in trait values resulted in movement of evolving populations within the trait-scape in both environments, but were more frequent when large populations evolved in a novel environment. Which trait relationships evolved was population-specific, but greater departures from ancestral trait correlations were associated with lower population growth rates. There was no single master trait that could be used to understand multi-trait evolution. Instead, repeatable multi-trait evolution occurred along a major axis of variation defined by several diatom traits and trait relationships. Because trait-scapes capture changes in trait relationships and values together, they offer an insightful way to study multi-trait variation.

Horder, J & Aharonovich, I 2024, 'Optical manipulation of spin resonance in gallium nitride', Nature Photonics, vol. 18, no. 4, pp. 309-310.
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Hossain, MS, Bacaoco, M, Mai, TNA, Ponchon, G, Chen, C, Ding, L, Chen, Y, Ekimov, E, Xu, X, Solntsev, AS & Tran, TT 2024, 'Fiber-Based Ratiometric Optical Thermometry with Silicon Vacancy in Microdiamonds', ACS Applied Optical Materials, vol. 2, no. 1, pp. 97-107.
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Htet, CS, Manjón-Sanz, AM, Liu, J, Babori, C, Barati, M, Marlton, FP, Daniel, L, Jørgensen, MRV & Pramanick, A 2024, 'Local structural mechanism for enhanced energy storage properties in heterovalent doped NaNbO3 ceramics', Journal of the European Ceramic Society, vol. 44, no. 3, pp. 1597-1609.
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Hu, X, Yu, J, Wang, Y, Guo, W, Zhang, X, Armand, M, Kang, F, Wang, G, Zhou, D & Li, B 2024, 'A Lithium Intrusion‐Blocking Interfacial Shield for Wide‐Pressure‐Range Solid‐State Lithium Metal Batteries', Advanced Materials, vol. 36, no. 7.
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AbstractLithium garnets are considered as promising solid‐state electrolytes for next‐generation solid‐state Li metal batteries (SSLBs). However, the Li intrusion driven by external stack pressure triggers premature of Li metal batteries. Herein, for the first time, an in situ constructed interfacial shield is reported to efficiently inhibit the pressure‐induced Li intrusion in SSLBs. Theoretical modeling and experimental investigations reveal that high‐hardness metallic Mo nanocrystals inside the shield effectively suppress Li dendrite growth without alloy hardening‐derived interfacial contact deterioration. Meanwhile the electrically insulated Li2S as a shield component considerably promotes interfacial wettability and hinders Li dendrite penetration into the bulk of garnet electrolyte. Interfacial shield‐protected Li6.4La3Zr1.4Ta0.6O12 (LLZTO)‐based cells exhibit significantly enhanced cyclability without short circuits under conventional pressures of ≈0.2 MPa and even at high pressure of up to 70 MPa; which is the highest endurable stack pressure reported for SSLBs using garnet electrolytes. These key findings are expected to promote the wide‐pressure‐range applications of SSLBs.

Huang, D, Zhang, L, Liu, Y, Wang, J, Zhang, J, Baines, KJ, Liu, G, Hsu, AC-Y, Wang, F, Chen, Z, Oliver, BG, Xie, M, Qin, L, Liu, D, Wan, H, Luo, F, Li, W, Wang, G & Gibson, PG 2024, 'Activated non-neuronal cholinergic system correlates with non-type 2 inflammation and exacerbations in severe asthma', Annals of Allergy, Asthma & Immunology.
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Huang, JE, Chen, Y, Ou, P, Ding, X, Yan, Y, Dorakhan, R, Lum, Y, Li, X-Y, Bai, Y, Wu, C, Fan, M, Lee, MG, Miao, RK, Liu, Y, O’Brien, C, Zhang, J, Tian, C, Liang, Y, Xu, Y, Luo, M, Sinton, D & Sargent, EH 2024, 'Selective Electrified Propylene-to-Propylene Glycol Oxidation on Activated Rh-Doped Pd', Journal of the American Chemical Society, vol. 146, no. 12, pp. 8641-8649.
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Huang, Z, Farahmandjou, M, Marlton, F, Guo, X, Gao, H, Sun, B & Wang, G 2024, 'Surface and structure engineering of MXenes for rechargeable batteries beyond lithium', Journal of Materiomics, vol. 10, no. 1, pp. 253-268.
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Hussain, MS, Gupta, G, Shahwan, M, Bansal, P, Kaur, H, Deorari, M, Pant, K, Ali, H, Singh, SK, Rama Raju Allam, VS, Paudel, KR, Dua, K, Kumarasamy, V & Subramaniyan, V 2024, 'Non-Coding RNA: A Key Regulator in the Glutathione-GPX4 Pathway of Ferroptosis', Non-coding RNA Research.
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Huston, W 2024, 'Immunological responses in a Chlamydia trachomatis vaccine trial', The Lancet Infectious Diseases.
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Idrees, S & Paudel, KR 2024, 'Bioinformatics prediction and screening of viral mimicry candidates through integrating known and predicted DMI data', Archives of Microbiology, vol. 206, no. 1.
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Idrees, S & Paudel, KR 2024, 'Proteome‐wide assessment of human interactome as a source of capturing domain–motif and domain‐domain interactions', Journal of Cell Communication and Signaling, vol. 18, no. 1.
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AbstractProtein–protein interactions (PPIs) play a crucial role in various biological processes by establishing domain–motif (DMI) and domain–domain interactions (DDIs). While the existence of real DMIs/DDIs is generally assumed, it is rarely tested; therefore, this study extensively compared high‐throughput methods and public PPI repositories as sources for DMI and DDI prediction based on the assumption that the human interactome provides sufficient data for the reliable identification of DMIs and DDIs. Different datasets from leading high‐throughput methods (Yeast two‐hybrid [Y2H], Affinity Purification coupled Mass Spectrometry [AP‐MS], and Co‐fractionation‐coupled Mass Spectrometry) were assessed for their ability to capture DMIs and DDIs using known DMI/DDI information. High‐throughput methods were not notably worse than PPI databases and, in some cases, appeared better. In conclusion, all PPI datasets demonstrated significant enrichment in DMIs and DDIs (p‐value <0.001), establishing Y2H and AP‐MS as reliable methods for predicting these interactions. This study provides valuable insights for biologists in selecting appropriate methods for predicting DMIs, ultimately aiding in SLiM discovery.

Idrees, S, Paudel, KR & Hansbro, PM 2024, 'Prediction of motif-mediated viral mimicry through the integration of host–pathogen interactions', Archives of Microbiology, vol. 206, no. 3.
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AbstractOne of the mechanisms viruses use in hijacking host cellular machinery is mimicking Short Linear Motifs (SLiMs) in host proteins to maintain their life cycle inside host cells. In the face of the escalating volume of virus-host protein–protein interactions (vhPPIs) documented in databases; the accurate prediction of molecular mimicry remains a formidable challenge due to the inherent degeneracy of SLiMs. Consequently, there is a pressing need for computational methodologies to predict new instances of viral mimicry. Our present study introduces a DMI-de-novo pipeline, revealing that vhPPIs catalogued in the VirHostNet3.0 database effectively capture domain-motif interactions (DMIs). Notably, both affinity purification coupled mass spectrometry and yeast two-hybrid assays emerged as good approaches for delineating DMIs. Furthermore, we have identified new vhPPIs mediated by SLiMs across different viruses. Importantly, the de-novo prediction strategy facilitated the recognition of several potential mimicry candidates implicated in the subversion of host cellular proteins. The insights gleaned from this research not only enhance our comprehension of the mechanisms by which viruses co-opt host cellular machinery but also pave the way for the development of novel therapeutic interventions.

Idrees, S, Paudel, KR, Sadaf, T & Hansbro, PM 2024, 'Uncovering domain motif interactions using high‐throughput protein–protein interaction detection methods', FEBS Letters, vol. 598, no. 7, pp. 725-742.
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Protein–protein interactions (PPIs) are often mediated by short linear motifs (SLiMs) in one protein and domain in another, known as domain–motif interactions (DMIs). During the past decade, SLiMs have been studied to find their role in cellular functions such as post‐translational modifications, regulatory processes, protein scaffolding, cell cycle progression, cell adhesion, cell signalling and substrate selection for proteasomal degradation. This review provides a comprehensive overview of the current PPI detection techniques and resources, focusing on their relevance to capturing interactions mediated by SLiMs. We also address the challenges associated with capturing DMIs. Moreover, a case study analysing the BioGrid database as a source of DMI prediction revealed significant known DMI enrichment in different PPI detection methods. Overall, it can be said that current high‐throughput PPI detection methods can be a reliable source for predicting DMIs.

Insuasty, A, Carrara, S, Xuechen, J, McNeill, CR, Hogan, C & Langford, SJ 2024, 'Aggregation‐Induced Emission of Naphthalene Diimides: Effect of Chain Length on Liquid and Solid‐Phase Emissive Properties', Chemistry – An Asian Journal, vol. 19, no. 9.
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AbstractThe aggregation‐induced emission (AIE) properties of a systematic series of naphthalene diimides (NDIs) varying the chain length at the imide positions have been studied. A solvophobic collapse of NDI units through the flash injection of THF NDI solutions in sonicating water triggers the formation of stable suspensions with enhanced fluorescence emissions. Shorter chains favor the π‐π stacking of NDI units through H‐aggregation producing a strong AIE effect showing remarkably high quantum yields that have not been observed for non core‐substitued NDIs previously. On the other hand, NDIs functionalized with longer chains lead to more disordered domains where π‐π stacking between NDI units is mainly given by J‐aggregation unfavoring the AIE effect.

Jacobson, JL, Akkaya‐Hocagil, T, Jacobson, SW, Coles, CD, Richardson, GA, Olson, HC, Day, NL, Carter, RC, Dodge, NC, Dang, K, Cook, RJ & Ryan, LM 2024, 'A dose–response analysis of the effects of prenatal alcohol exposure on cognitive development', Alcohol, Clinical and Experimental Research, vol. 48, no. 4, pp. 623-639.
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AbstractBackgroundMost studies of the effects of prenatal alcohol exposure (PAE) on cognitive function have assumed that the dose–response curve is linear. However, data from a few animal and human studies suggest that there may be an inflection point in the dose–response curve above which PAE effects are markedly stronger and that there may be differences associated with pattern of exposure, assessed in terms of alcohol dose per drinking occasion and drinking frequency.MethodsWe performed second‐order confirmatory factor analysis on data obtained at school age, adolescence, and early adulthood from 2227 participants in six US longitudinal cohorts to derive a composite measure of cognitive function. Regression models were constructed to examine effects of PAE on cognitive function, adjusted for propensity scores. Analyses based on a single predictor (absolute alcohol (AA)/day) were compared with analyses based on two predictors (dose/occasion and drinking frequency), using (1) linear models and (2) nonparametric general additive models (GAM) that allow for both linear and nonlinear effects.ResultsThe single‐predictor GAM model showed virtually no nonlinearity in the effect of AA/day on cognitive function. However, the two‐predictor GAM model revealed differential effects of maternal drinking pattern. Among offspring of infrequent drinkers, PAE effects on cognitive function were markedly stronger in those whose mothers drank more than ~3 drinks/occasion, and the effect of dose/occasion was strongest among the very frequent drinkers. Frequency of drinking did not appear to alter the PAE effect on cognitive function among participants born to mothers who limited their drinking to ~1 drink/occasion or less.Conclusions

Jessamine, V, Mehndiratta, S, De Rubis, G, Paudel, KR, Shetty, S, Suares, D, Chellappan, DK, Oliver, BG, Hansbro, PM & Dua, K 2024, 'The application of nanoparticles as advanced drug delivery systems in Attenuating COPD', Heliyon, vol. 10, no. 3, pp. e25393-e25393.
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Jha, LA, Kumar, B, Jha, SK & Paudel, KR 2024, 'Futuristic Senolytic Drug Incorporated Nanomedicine Therapy to Treat Osteoarthritis', Nanomedicine, vol. 19, no. 10, pp. 837-840.
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Jing, L, Deplazes, E, Clegg, JK & Wu, X 2024, 'A charge-neutral organic cage selectively binds strongly hydrated sulfate anions in water', Nature Chemistry, vol. 16, no. 3, pp. 335-342.
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Johnston, NP, Pape, T, Piwczyński, M, Wallman, JF, Wiegmann, BM, Cassel, BK, Akbarzadeh, K & Szpila, K 2024, 'Anchored phylogenomics and revised classification of the Miltogramminae (Diptera: Sarcophagidae)', Systematic Entomology, vol. 49, no. 1, pp. 138-155.
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AbstractThe Miltogramminae (Diptera: Sarcophagidae) includes ~600 species across >40 genera, which constitute ~20% of global Sarcophagidae. While molecular phylogenetic hypotheses have been produced for this group, critical problems persist, including the presence of paraphyletic genera, uncertain relationships between genera, a bias of sampling towards Palaearctic taxa, and low support for many branches. The present study remedies these issues through the application of Anchored Hybrid Enrichment (AHE) to a sample including ~60% of the currently recognised genera (16% of known species) representing all biogeographic regions except the Neotropical. An alignment of 1,281 concatenated loci was analysed with maximum likelihood (RAxML, IQ‐TREE), Bayesian inference (ExaBayes) and coalescent‐based approaches (ASTRAL, SVDquartets), which resulted in highly supported and concordant topologies, providing unprecedented insight into the relationships of this subfamily of flesh flies, allowing a major update to miltogrammine classification. The AHE phylogenetic hypothesis supports the monophyly of a large proportion of genera. The monophyly of Metopia Meigen is restored by synonymy with Aenigmetopia Malloch, syn.n. To achieve monophyly of Miltogramma Meigen, eight species are transferred from Pterella Robineau‐Desvoidy. The genus Pterella is shown to be paraphyletic in its current circumscription, and to restore generic monophyly Pterella is restricted to contain only Pt. grisea (Meigen). Erioprocta Enderlein, stat.rev., is resurrected. The genus Senotainia Macquart is reconstructed as paraphyletic. The monotypic genus Metopodia

Kakoty, V, Sarathlal, KC, Kaur, P, Wadhwa, P, Vishwas, S, Khan, FR, Alhazmi, AYM, Almasoudi, HH, Gupta, G, Chellappan, DK, Paudel, KR, Kumar, D, Dua, K & Singh, SK 2024, 'Unraveling the role of glial cell line–derived neurotrophic factor in the treatment of Parkinson’s disease', Neurological Sciences, vol. 45, no. 4, pp. 1409-1418.
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Karami, H, Kamruzzaman, M, Covington, JA, Hassouna, MÉ, Darvishi, Y, Ueland, M, Fuentes, S & Gancarz, M 2024, 'Advanced evaluation techniques: Gas sensor networks, machine learning, and chemometrics for fraud detection in plant and animal products', Sensors and Actuators A: Physical, vol. 370, pp. 115192-115192.
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Khalenkow, D, Brandsma, C-A, Timens, W, Choy, DF, Grimbaldeston, MA, Rosenberger, CM, Slebos, D-J, Kerstjens, HAM, Faiz, A, Koppelman, GH, Nawijn, MC, van den Berge, M & Guryev, V 2024, 'Alternative Splicing Is a Major Factor Shaping Transcriptome Diversity in Mild and Severe Chronic Obstructive Pulmonary Disease', American Journal of Respiratory Cell and Molecular Biology, vol. 70, no. 5, pp. 414-423.
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Kim, J, Rose, ML, Pierce, JE, Nickels, L, Copland, DA, Togher, L, Godecke, E, Meinzer, M, Rai, T, Hurley, M, Foster, A, Carragher, M, Wilcox, C & Cadilhac, DA 2024, 'High-Intensity Aphasia Therapy Is Cost-Effective in People With Poststroke Aphasia: Evidence From the COMPARE Trial', Stroke, vol. 55, no. 3, pp. 705-714.
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BACKGROUND: Evidence from systematic reviews confirms that speech and language interventions for people with aphasia during the chronic phase after stroke (>6 months) improve word retrieval, functional communication, and communication-related quality of life. However, there is limited evidence of their cost-effectiveness. We aimed to estimate the cost per quality-adjusted life year gained from 2 speech and language therapies compared with usual care in people with aphasia during the chronic phase (median, 2.9 years) after stroke. METHODS: A 3-arm, randomized controlled trial compared constraint-induced aphasia therapy plus (CIAT-Plus) and multimodality aphasia therapy (M-MAT) with usual care in 216 people with chronic aphasia. Participants were administered a standardized questionnaire before intervention and at 12 weeks after the 2-week intervention/control period to ascertain health service utilization, employment changes, and informal caregiver burden. Unit prices from Australian sources were used to estimate costs in 2020. Quality-adjusted life years were estimated using responses to the EuroQol-5 Dimension-3 Level questionnaire. To test uncertainty around the differences in costs and outcomes between groups, bootstrapping was used with the cohorts resampled 1000 times. RESULTS: Overall 201/216 participants were included (mean age, 63 years, 29% moderate or severe aphasia, 61 usual care, 70 CIAT-Plus, 70 M-MAT). There were no statistically significant differences in mean total costs ($13 797 usual care, $17 478 CIAT-Plus, $11 113 M-MAT) and quality-adjusted life years (0.19 usual care, 0.20 CIAT-Plus, 0.20 M-MAT) between groups. In bootstrapped analysis of CIAT-Plus...

Kim, J, Sookram, G, Godecke, E, Brogan, E, Armstrong, E, Ellery, F, Rai, T, Rose, ML, Ciccone, N, Middleton, S, Holland, A, Hankey, GJ, Bernhardt, J & Cadilhac, DA 2024, 'Economic evaluation of the Very Early Rehabilitation in SpEech (VERSE) intervention', Topics in Stroke Rehabilitation, vol. 31, no. 2, pp. 157-166.
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Knights, AM, Lemasson, AJ, Firth, LB, Beaumont, N, Birchenough, S, Claisse, J, Coolen, JWP, Copping, A, De Dominicis, M, Degraer, S, Elliott, M, Fernandes, PG, Fowler, AM, Frost, M, Henry, L-A, Hicks, N, Hyder, K, Jagerroos, S, Love, M, Lynam, C, Macreadie, PI, McLean, D, Marlow, J, Mavraki, N, Montagna, PA, Paterson, DM, Perrow, MR, Porter, J, Bull, AS, Schratzberger, M, Shipley, B, van Elden, S, Vanaverbeke, J, Want, A, Watson, SCL, Wilding, TA & Somerfield, PJ 2024, 'To what extent can decommissioning options for marine artificial structures move us toward environmental targets?', Journal of Environmental Management, vol. 350, pp. 119644-119644.
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Switching from fossil fuels to renewable energy is key to international energy transition efforts and the move toward net zero. For many nations, this requires decommissioning of hundreds of oil and gas infrastructure in the marine environment. Current international, regional and national legislation largely dictates that structures must be completely removed at end-of-life although, increasingly, alternative decommissioning options are being promoted and implemented. Yet, a paucity of real-world case studies describing the impacts of decommissioning on the environment make decision-making with respect to which option(s) might be optimal for meeting international and regional strategic environmental targets challenging. To address this gap, we draw together international expertise and judgment from marine environmental scientists on marine artificial structures as an alternative source of evidence that explores how different decommissioning options might ameliorate pressures that drive environmental status toward (or away) from environmental objectives. Synthesis reveals that for 37 United Nations and Oslo-Paris Commissions (OSPAR) global and regional environmental targets, experts consider repurposing or abandoning individual structures, or abandoning multiple structures across a region, as the options that would most strongly contribute toward targets. This collective view suggests complete removal may not be best for the environment or society. However, different decommissioning options act in different ways and make variable contributions toward environmental targets, such that policy makers and managers would likely need to prioritise some targets over others considering political, social, economic, and ecological contexts. Current policy may not result in optimal outcomes for the environment or society.

Knights, AM, Lemasson, AJ, Firth, LB, Bond, T, Claisse, J, Coolen, JWP, Copping, A, Dannheim, J, De Dominicis, M, Degraer, S, Elliott, M, Fernandes, PG, Fowler, AM, Frost, M, Henry, L-A, Hicks, N, Hyder, K, Jagerroos, S, Jones, DOB, Love, M, Lynam, CP, Macreadie, PI, Marlow, J, Mavraki, N, McLean, D, Montagna, PA, Paterson, DM, Perrow, M, Porter, J, Russell, DJF, Bull, AS, Schratzberger, M, Shipley, B, van Elden, S, Vanaverbeke, J, Want, A, Watson, SCL, Wilding, TA & Somerfield, P 2024, 'Developing expert scientific consensus on the environmental and societal effects of marine artificial structures prior to decommissioning', Journal of Environmental Management, vol. 352, pp. 119897-119897.
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Kokkinis, S, De Rubis, G, Paudel, KR, Patel, VK, Yeung, S, Jessamine, V, MacLoughlin, R, Hansbro, PM, Oliver, B & Dua, K 2024, 'Liposomal curcumin inhibits cigarette smoke induced senescence and inflammation in human bronchial epithelial cells', Pathology - Research and Practice, pp. 155423-155423.
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Kokkinis, S, Singh, M, Paudel, KR, De Rubis, G, Bani Saeid, A, Jessamine, V, Datsyuk, J, Singh, SK, Vishwas, S, Adams, J, Hansbro, PM, Oliver, B, Gupta, G, Dureja, H & Dua, K 2024, 'Plant-based therapeutics for chronic obstructive pulmonary diseases: Nanoformulation strategies to overcome delivery challenges', Food Bioscience, vol. 58, pp. 103761-103761.
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Kwak, ML, Wallman, JF, Yeo, D, Archer, MS & Nakao, R 2024, 'Forensic parasitology: a new frontier in criminalistics', Forensic Sciences Research, vol. 9, no. 2.
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Abstract Parasites are ubiquitous, diverse, and have close interactions with humans and other animals. Despite this, they have not garnered significant interest from forensic scientists, and their utility as indicators in criminal investigations has been largely overlooked. To foster the development of forensic parasitology we explore the utility of parasites as forensic indicators in five broad areas: (i) wildlife trafficking and exploitation, (ii) biological attacks, (iii) sex crimes, (iv) criminal neglect of humans and other animals, and (v) indicators of movement and travel. To encourage the development and growth of forensic parasitology as a field, we lay out a four-step roadmap to increase the use and utility of parasites in criminal investigations.

Lai, N, Chang, G, Yang, Y, He, M, Tang, W, Huang, Q, Zhang, Q, Su, QP, Liao, J, Yang, Y, Wang, C & Wang, R 2024, 'CsPbX3 quantum Dots@ZIF-8 composites with enhanced luminescence emission and stability', Journal of Luminescence, vol. 266, pp. 120280-120280.
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Lean, I, Zadoks, R, Brito, B & Golder, H 2024, 'Milk as a diagnostic fluid', Australian Veterinary Journal, vol. 102, no. 1-2, pp. 3-4.
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Leong, RC, Bugnot, AB, Ross, PM, Erickson, KR, Gibbs, MC, Marzinelli, EM, O'Connor, WA, Parker, LM, Poore, AGB, Scanes, E & Gribben, PE 2024, 'Recruitment of a threatened foundation oyster species varies with large and small spatial scales', Ecological Applications, vol. 34, no. 4.
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AbstractUnderstanding how habitat attributes (e.g., patch area and sizes, connectivity) control recruitment and how this is modified by processes operating at larger spatial scales is fundamental to understanding population sustainability and developing successful long‐term restoration strategies for marine foundation species—including for globally threatened reef‐forming oysters. In two experiments, we assessed the recruitment and energy reserves of oyster recruits onto remnant reefs of the oyster Saccostrea glomerata in estuaries spanning 550 km of coastline in southeastern Australia. In the first experiment, we determined whether recruitment of oysters to settlement plates in three estuaries was correlated with reef attributes within patches (distances to patch edges and surface elevation), whole‐patch attributes (shape and size of patches), and landscape attributes (connectivity). We also determined whether environmental factors (e.g., sedimentation and water temperature) explained the differences among recruitment plates. We also tested whether differences in energy reserves of recruits could explain the differences between two of the estuaries (one high‐ and one low‐sedimentation estuary). In the second experiment, across six estuaries (three with nominally high and three with nominally low sedimentation rates), we tested the hypothesis that, at the estuary scale, recruitment and survival were negatively correlated to sedimentation. Overall, total oyster recruitment varied mostly at the scale of estuaries rather than with reef attributes and was negatively correlated with sedimentation. Percentage recruit survival was, however, similar among estuaries, although energy reserves and condition of recruits were lower at a high‐ compared to a low‐sediment estuary. Within each estuary, total oyster recruitment increased with patch area and decreased with increasing tidal height. Our results sho...

Li, D, Jia, J, Zeng, H, Zhong, X, Chen, H & Yi, C 2024, 'Efficacy of exercise rehabilitation for managing patients with Alzheimer’s disease', Neural Regeneration Research, vol. 19, no. 10, pp. 2175-2188.
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Alzheimer’s disease (AD) is a progressive and degenerative neurological disease characterized by the deterioration of cognitive functions. While a definitive cure and optimal medication to impede disease progression are currently unavailable, a plethora of studies have highlighted the potential advantages of exercise rehabilitation for managing this condition. Those studies show that exercise rehabilitation can enhance cognitive function and improve the quality of life for individuals affected by AD. Therefore, exercise rehabilitation has been regarded as one of the most important strategies for managing patients with AD. Herein, we provide a comprehensive analysis of the currently available findings on exercise rehabilitation in patients with AD, with a focus on the exercise types which have shown efficacy when implemented alone or combined with other treatment methods, as well as the potential mechanisms underlying these positive effects. Specifically, we explain how exercise may improve the brain microenvironment and neuronal plasticity. In conclusion, exercise is a cost-effective intervention to enhance cognitive performance and improve quality of life in patients with mild to moderate cognitive dysfunction. Therefore, it can potentially become both a physical activity and a tailored intervention. This review may aid the development of more effective and individualized treatment strategies to address the challenges imposed by this debilitating disease, especially in low- and middle-income countries.

Li, J, Gao, L, Pan, F, Gong, C, Sun, L, Gao, H, Zhang, J, Zhao, Y, Wang, G & Liu, H 2024, 'Engineering Strategies for Suppressing the Shuttle Effect in Lithium–Sulfur Batteries', Nano-Micro Letters, vol. 16, no. 1.
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AbstractLithium–sulfur (Li–S) batteries are supposed to be one of the most potential next-generation batteries owing to their high theoretical capacity and low cost. Nevertheless, the shuttle effect of firm multi-step two-electron reaction between sulfur and lithium in liquid electrolyte makes the capacity much smaller than the theoretical value. Many methods were proposed for inhibiting the shuttle effect of polysulfide, improving corresponding redox kinetics and enhancing the integral performance of Li–S batteries. Here, we will comprehensively and systematically summarize the strategies for inhibiting the shuttle effect from all components of Li–S batteries. First, the electrochemical principles/mechanism and origin of the shuttle effect are described in detail. Moreover, the efficient strategies, including boosting the sulfur conversion rate of sulfur, confining sulfur or lithium polysulfides (LPS) within cathode host, confining LPS in the shield layer, and preventing LPS from contacting the anode, will be discussed to suppress the shuttle effect. Then, recent advances in inhibition of shuttle effect in cathode, electrolyte, separator, and anode with the aforementioned strategies have been summarized to direct the further design of efficient materials for Li–S batteries. Finally, we present prospects for inhibition of the LPS shuttle and potential development directions in Li–S batteries.

Li, K, Akkaya-Hocagil, T, Cook, RJ, Ryan, LM, Carter, RC, Dang, K-D, Jacobson, JL & Jacobson, SW 2024, 'Use of Generalized Propensity Scores for Assessing Effects of Multiple Exposures', Statistics in Biosciences, vol. 16, no. 2, pp. 347-376.
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Li, S, Wang, B, Liu, DL, Chen, C, Feng, P, Huang, M, Wang, X, Shi, L, Waters, C, Huete, A & Yu, Q 2024, 'Can agronomic options alleviate the risk of compound drought-heat events during the wheat flowering period in southeastern Australia?', European Journal of Agronomy, vol. 153, pp. 127030-127030.
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Liu, C, Ye, C, Zhang, T, Tang, J, Mao, K, Chen, L, Xue, L, Sun, J, Zhang, W, Wang, X, Xiong, P, Wang, G & Zhu, J 2024, 'Bio‐inspired Double Angstrom‐Scale Confinement in Ti‐deficient Ti_0.87O₂ Nanosheet Membranes for Ultrahigh‐performance Osmotic Power Generation', Angewandte Chemie International Edition, vol. 63, no. 4.
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AbstractOsmotic power, a clean energy source, can be harvested from the salinity difference between seawater and river water. However, the output power densities are hampered by the trade‐off between ion selectivity and ion permeability. Here we propose an effective strategy of double angstrom‐scale confinement (DAC) to design ion‐permselective channels with enhanced ion selectivity and permeability simultaneously. The fabricated DAC‐Ti0.87O2 membranes possess both Ti atomic vacancies and an interlayer free spacing of ≈2.2 Å, which not only generates a profitable confinement effect for Na+ ions to enable high ion selectivity but also induces a strong interaction with Na+ ions to benefit high ion permeability. Consequently, when applied to osmotic power generation, the DAC‐Ti0.87O2 membranes achieved an ultrahigh power density of 17.8 W m−2 by mixing 0.5/0.01 M NaCl solution and up to 114.2 W m−2 with a 500‐fold salinity gradient, far exceeding all the reported macroscopic‐scale membranes. This work highlights the potential of the construction of DAC ion‐permselective channels for two‐dimensional materials in high‐performance nanofluidic energy systems.

Liu, C, Ye, C, Zhang, T, Tang, J, Mao, K, Chen, L, Xue, L, Sun, J, Zhang, W, Wang, X, Xiong, P, Wang, G & Zhu, J 2024, 'Bio‐inspired Double Angstrom‐Scale Confinement in Ti‐deficient Ti_0.87O₂ Nanosheet Membranes for Ultrahigh‐performance Osmotic Power Generation', Angewandte Chemie, vol. 136, no. 4.
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AbstractOsmotic power, a clean energy source, can be harvested from the salinity difference between seawater and river water. However, the output power densities are hampered by the trade‐off between ion selectivity and ion permeability. Here we propose an effective strategy of double angstrom‐scale confinement (DAC) to design ion‐permselective channels with enhanced ion selectivity and permeability simultaneously. The fabricated DAC‐Ti0.87O2 membranes possess both Ti atomic vacancies and an interlayer free spacing of ≈2.2 Å, which not only generates a profitable confinement effect for Na+ ions to enable high ion selectivity but also induces a strong interaction with Na+ ions to benefit high ion permeability. Consequently, when applied to osmotic power generation, the DAC‐Ti0.87O2 membranes achieved an ultrahigh power density of 17.8 W m−2 by mixing 0.5/0.01 M NaCl solution and up to 114.2 W m−2 with a 500‐fold salinity gradient, far exceeding all the reported macroscopic‐scale membranes. This work highlights the potential of the construction of DAC ion‐permselective channels for two‐dimensional materials in high‐performance nanofluidic energy systems.

Liu, T, Zhang, W, Wang, L, Ueland, M, Forbes, SL, Zheng, WX & Su, SW 2024, 'Numerical Differentiation From Noisy Signals: A Kernel Regularization Method to Improve Transient-State Features for the Electronic Nose', IEEE Transactions on Systems, Man, and Cybernetics: Systems, vol. 54, no. 6, pp. 3497-3511.
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Liu, Z, Sun, B, Zhang, Y, Zhang, Q & Fan, L 2024, 'Polymer-adjusted zinc anode towards high-performance aqueous zinc ion batteries', Progress in Polymer Science, vol. 152, pp. 101817-101817.
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Lockwood, TE, Banati, RB, Nikagolla, C, Violi, JP & Bishop, DP 2024, 'Concentration and Distribution of Toxic and Essential Elements in Traditional Rice Varieties of Sri Lanka Grown on an Anuradhapura District Farm', Biological Trace Element Research, vol. 202, no. 6, pp. 2891-2899.
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AbstractToxic heavy metals have been the focus of many investigations into chronic kidney disease of unknown aetiology (CKDu) within Sri Lanka. It has been hypothesised that exposure to nephrotoxic arsenic, cadmium and lead could play a role in the development of CKDu, and these metals have previously been found in unsafe concentrations in Sri Lankan rice. Traditional varieties of Sri Lankan rice remain popular due to their perceived health benefits, but their uptake of trace and toxic heavy metals remained unexplored. Here, we report a one-time, cross-sectional dataset on the concentrations of essential and toxic elements present in eleven samples of polished and unpolished traditional rice varieties, all regularly grown and sold in the Anuradhapura district, a CKDu hotspot. All rice was sourced from the same farm, with the exception of one store bought sample grown on another, unidentified farm. Cadmium concentrations varied significantly between varieties, and potentially unsafe concentrations of cadmium were detected in the store-bought sample (Suwadel, 113±13 μg kg−1). Elemental imaging of the grains revealed lead to be stored mainly in the rice bran, which is removed during polishing, while cadmium was distributed in the edible portion of the grain. Essential elements were generally higher in the traditional rice varieties than those reported for non-traditional varieties and are a potential source of trace elements for nutrient-deficient communities. The concentration of selenium, an element that plays a protective role in the kidneys, was too low to provide the minimum recommended intake. The methods developed in this study could be applied to a more comprehensive study of elemental uptake of rice under controlled growing conditions.

Luong, HA, Rohlfs, A-M, Facey, JA, Colville, A & Mitrovic, SM 2024, 'Long-term study of phytoplankton dynamics in a supply reservoir reveals signs of trophic state shift linked to changes in hydrodynamics associated with flow management and extreme events', Water Research, vol. 256, pp. 121547-121547.
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Ma, J, Chen, Y, Li, T, Cao, Y, Hu, B, Liu, Y, Zhang, Y, Li, X, Liu, J, Zhang, W, Niu, H, Gao, J, Zhang, Z, Yue, K, Wang, J, Bao, G, Wang, C, Wang, PG, Zou, T & Xie, S 2024, 'Suppression of lysosome metabolism-meditated GARP/TGF-β1 complexes specifically depletes regulatory T cells to inhibit breast cancer metastasis', Oncogene, vol. 43, no. 25, pp. 1930-1940.
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Ma, J, Zhang, J, Horder, J, Sukhorukov, AA, Toth, M, Neshev, DN & Aharonovich, I 2024, 'Engineering Quantum Light Sources with Flat Optics', Advanced Materials, vol. 36, no. 23.
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AbstractQuantum light sources are essential building blocks for many quantum technologies, enabling secure communication, powerful computing, and precise sensing and imaging. Recent advancements have witnessed a significant shift toward the utilization of “flat” optics with thickness at subwavelength scales for the development of quantum light sources. This approach offers notable advantages over conventional bulky counterparts, including compactness, scalability, and improved efficiency, along with added functionalities. This review focuses on the recent advances in leveraging flat optics to generate quantum light sources. Specifically, the generation of entangled photon pairs through spontaneous parametric down‐conversion in nonlinear metasurfaces, and single photon emission from quantum emitters including quantum dots and color centers in 3D and 2D materials are explored. The review covers theoretical principles, fabrication techniques, and properties of these sources, with particular emphasis on the enhanced generation and engineering of quantum light sources using optical resonances supported by nanostructures. The diverse application range of these sources is discussed and the current challenges and perspectives in the field are highlighted.

Mahmodi, H, Poulton, CG, Leslie, MN, Oldham, G, Ong, HX, Langford, SJ & Kabakova, IV 2024, 'Principal component analysis in application to Brillouin microscopy data', Journal of Physics: Photonics, vol. 6, no. 2, pp. 025009-025009.
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Abstract Brillouin microscopy has recently emerged as a new bio-imaging modality that provides information on the microscale mechanical properties of biological materials, cells and tissues. The data collected in a typical Brillouin microscopy experiment represents the high-dimensional set of spectral information, i.e. each pixel within a 2D/3D Brillouin image is associated with hundreds of points of spectral data. Its analysis requires non-trivial approaches due to subtlety in spectral variations as well as spatial and spectral overlaps of measured features. This article offers a guide to the application of Principal Component Analysis (PCA) for processing Brillouin imaging data. Being unsupervised multivariate analysis, PCA is well-suited to tackle processing of complex Brillouin spectra from heterogeneous biological samples with minimal a priori information requirements. We point out the importance of data pre-processing steps in order to improve outcomes of PCA. We also present a strategy where PCA combined with k-means clustering method can provide a working solution to data reconstruction and deeper insights into sample composition, structure and mechanics.

Mahmood, A, Zheng, Z & Chen, Y 2024, 'Zinc–Bromine Batteries: Challenges, Prospective Solutions, and Future', Advanced Science, vol. 11, no. 3, p. e2305561.
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AbstractZinc‐bromine batteries (ZBBs) have recently gained significant attention as inexpensive and safer alternatives to potentially flammable lithium‐ion batteries. Zn metal is relatively stable in aqueous electrolytes, making ZBBs safer and easier to handle. However, Zn metal anodes are still affected by several issues, including dendrite growth, Zn dissolution, and the crossover of Br species from cathodes to corrode anodes, resulting in self‐discharge and fast performance fading. Similarly, Br2 undergoes sluggish redox reactions on cathodes, which brings several issues such as poor reaction kinetics, the highly corrosive nature of Br species leading to corrosion of separators and poisoning of anodes, and the volatile nature of Br species causing increased internal pressures, etc. These issues are compounded in flowless ZBB configuration as no fresh electrolyte is available to provide extra/fresh reaction species. In this review, the factors controlling the performance of ZBBs in flow and flowless configurations are thoroughly reviewed, along with the status of ZBBs in the commercial sector. The review also summarizes various novel methodologies to mitigate these challenges and presents research areas for future studies. In summary, this review will offer a perspective on the historical evolution, recent advancements, and prospects of ZBBs.

Mai, TNA, Ali, S, Hossain, MS, Chen, C, Ding, L, Chen, Y, Solntsev, AS, Mou, H, Xu, X, Medhekar, N & Tran, TT 2024, 'Cryogenic Thermal Shock Effects on Optical Properties of Quantum Emitters in Hexagonal Boron Nitride', ACS Applied Materials & Interfaces, vol. 16, no. 15, pp. 19340-19349.
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Solid-state quantum emitters are vital building blocks for quantum information science and quantum technology. Among various types of solid-state emitters discovered to date, color centers in hexagonal boron nitride have garnered tremendous traction in recent years, thanks to their environmental robustness, high brightness, and room-temperature operation. Most recently, these quantum emitters have been employed for satellite-based quantum key distribution. One of the most important requirements to qualify these emitters for space-based applications is their optical stability against cryogenic thermal shock. Such an understanding has, however, remained elusive to date. Here, we report on the effects caused by such thermal shock that induces random, irreversible changes in the spectral characteristics of the quantum emitters. By employing a combination of structural characterizations and density functional calculations, we attribute the observed changes to lattice strain caused by cryogenic temperature shock. Our study sheds light on the stability of the quantum emitters under extreme conditions─similar to those countered in outer space.

Mamun, SMN, Kumar Paul, D, Matar, F, Ton-That, C & Rahman, MA 2024, 'Zinc Dopant-Induced Modulation of Electronic Structure and Defect Emissions in Monoclinic Gallium Oxide', The Journal of Physical Chemistry C, vol. 128, no. 11, pp. 4722-4728.
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Manandhar, B, Paudel, KR, Clarence, DD, De Rubis, G, Madheswaran, T, Panneerselvam, J, Zacconi, FC, Williams, KA, Pont, LG, Warkiani, ME, MacLoughlin, R, Oliver, BG, Gupta, G, Singh, SK, Chellappan, DK, Hansbro, PM & Dua, K 2024, 'Zerumbone-incorporated liquid crystalline nanoparticles inhibit proliferation and migration of non-small-cell lung cancer in vitro', Naunyn-Schmiedeberg's Archives of Pharmacology, vol. 397, no. 1, pp. 343-356.
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AbstractLung cancer is the second most prevalent type of cancer and is responsible for the highest number of cancer-related deaths worldwide. Non-small-cell lung cancer (NSCLC) makes up the majority of lung cancer cases. Zerumbone (ZER) is natural compound commonly found in the roots of Zingiber zerumbet which has recently demonstrated anti-cancer activity in both in vitro and in vivo studies. Despite their medical benefits, ZER has low aqueous solubility, poor GI absorption and oral bioavailability that hinders its effectiveness. Liquid crystalline nanoparticles (LCNs) are novel drug delivery carrier that have tuneable characteristics to enhance and ease the delivery of bioactive compounds. This study aimed to formulate ZER-loaded LCNs and investigate their effectiveness against NSCLC in vitro using A549 lung cancer cells. ZER-LCNs, prepared in the study, inhibited the proliferation and migration of A549 cells. These inhibitory effects were superior to the effects of ZER alone at a concentration 10 times lower than that of free ZER, demonstrating a potent anti-cancer activity of ZER-LCNs. The underlying mechanisms of the anti-cancer effects by ZER-LCNs were associated with the transcriptional regulation of tumor suppressor genes P53 and PTEN, and metastasis-associated gene KRT18. The protein array data showed downregulation of several proliferation associated proteins such as AXL, HER1, PGRN, and BIRC5 and metastasis-associated proteins such as DKK1, CAPG, CTSS, CTSB, CTSD, and PLAU. This study provides evidence of potential for increasing the potency and effectiveness of ZER with LCN formulation and developing ZER-LCNs as a treatment strategy for mitigation and treatment of NSCLC.

McKnight, DJE, Wong-Bajracharya, J, Okoh, EB, Snijders, F, Lidbetter, F, Webster, J, Haughton, M, Darling, AE, Djordjevic, SP, Bogema, DR & Chapman, TA 2024, 'Xanthomonas rydalmerensis sp. nov., a non-pathogenic member of Group 1 Xanthomonas', International Journal of Systematic and Evolutionary Microbiology, vol. 74, no. 3.
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Five bacterial isolates were isolated from Fragaria × ananassa in 1976 in Rydalmere, Australia, during routine biosecurity surveillance. Initially, the results of biochemical characterisation indicated that these isolates represented members of the genus Xanthomonas. To determine their species, further analysis was conducted using both phenotypic and genotypic approaches. Phenotypic analysis involved using MALDI-TOF MS and BIOLOG GEN III microplates, which confirmed that the isolates represented members of the genus Xanthomonas but did not allow them to be classified with respect to species. Genome relatedness indices and the results of extensive phylogenetic analysis confirmed that the isolates were members of the genus Xanthomonas and represented a novel species. On the basis the minimal presence of virulence-associated factors typically found in genomes of members of the genus Xanthomonas, we suggest that these isolates are non-pathogenic. This conclusion was supported by the results of a pathogenicity assay. On the basis of these findings, we propose the name Xanthomonas rydalmerensis, with DAR 34855T = ICMP 24941 as the type strain.

Meakin, GE, Jacques, GS & Morgan, RM 2024, 'Comparison of DNA recovery methods and locations from regularly-worn hooded jumpers before and after use by a second wearer', Science & Justice, vol. 64, no. 2, pp. 232-242.
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Mediati, DG, Dan, W, Lalaouna, D, Dinh, H, Pokhrel, A, Rowell, KN, Michie, KA, Stinear, TP, Cain, AK & Tree, JJ 2024, 'The 3′ UTR of vigR is required for virulence in Staphylococcus aureus and has expanded through STAR sequence repeat insertions', Cell Reports, vol. 43, no. 4, pp. 114082-114082.
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Mehta, M, Bui, TA, Care, A & Deng, W 2024, 'Targeted polymer lipid hybrid nanoparticles for in-vitro siRNA therapy in triple-negative breast cancer', Journal of Drug Delivery Science and Technology, pp. 105911-105911.
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Mello, MG, Westerhausen, MT, Lockwood, TE, Singh, P, Wanagat, J & Bishop, DP 2024, 'Immunolabelling perturbs the endogenous and antibody-conjugated elemental concentrations during immuno-mass spectrometry imaging', Analytical and Bioanalytical Chemistry, vol. 416, no. 11, pp. 2725-2735.
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AbstractImmuno-mass spectrometry imaging uses lanthanide-conjugated antibodies to spatially quantify biomolecules via laser ablation-inductively coupled plasma-mass spectrometry (LA-ICP-MS). The multi-element capabilities allow for highly multiplexed analyses that may include both conjugated antibodies and endogenous metals to reveal relationships between disease and chemical composition. Sample handling is known to perturb the composition of the endogenous elements, but there has been little investigation into the effects of immunolabelling and coverslipping. Here, we used cryofixed muscle sections to examine the impact of immunolabelling steps on the concentrations of a Gd-conjugated anti-dystrophin primary antibody, and the endogenous metals Cu and Zn. Primary antibody incubation resulted in a decrease in Zn, and an increase in Cu. Zn was removed from the cytoplasm where it was hypothesised to be more labile, whereas concentrated locations of Zn remained in the cell membrane in all samples that underwent the immunostaining process. Cu increased in concentration and was found mostly in the cell membrane. The concentration of the Gd-conjugated antibody when compared to the standard air-dried sample was not significantly different when coverslipped using an organic mounting medium, whereas use of an aqueous mounting medium significantly reduced the concentration of Gd. These results build on the knowledge of how certain sample handling techniques change elemental concentrations and distributions in tissue sections. Immunolabelling steps impact the concentration of endogenous elements, and separate histological sections are required for the quantitative analysis of endogenous elements and biomolecules. Additionally, coverslipping tissue sections for complementary immunohistochemical/immunofluorescent imaging may compromise the integrity of the elemental label, and organic mounting media are recommended over aqueous mounti...

Merklein, M, Goulden, L, Kiewiet, M, Liu, Y, Lai, CK, Choi, D-Y, Madden, SJ, Poulton, CG & Eggleton, BJ 2024, 'On-chip quasi-light storage for long optical delays using Brillouin scattering', APL Photonics, vol. 9, no. 5.
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Efficient and extended light storage mechanisms are pivotal in photonics, particularly in optical communications, microwave photonics, and quantum networks, as they offer a direct route to circumvent electrical conversion losses and surmount bandwidth constraints. Stimulated Brillouin Scattering (SBS) is an established method to store optical information by transferring it to the acoustic domain, but current on-chip SBS efforts have limited bandwidth or storage time due to the phonon lifetime of several nanoseconds. An alternate approach known as quasi-light storage (QLS), which involves the creation of delayed replicas of optical data pulses via SBS in conjunction with a frequency comb, has been proposed to lift the storage time constraint; however, its realization has been confined to lengthy optical fibers, constraining integration with on-chip optical elements and form factors. Here, we present an experimental demonstration of QLS on a photonic chip leveraging the large SBS gain of chalcogenide glass, achieving delays of up to 500 ns for 1 ns long signal pulses, surpassing typical Brillouin storage processes' acoustic lifetime by more than an order of magnitude and waveguide transit time by two orders of magnitude. We experimentally and numerically investigate the dynamics of on-chip QLS and reveal that the interplay between the acoustic wave that stores the optical signal and subsequent optical pump pulses leads to a reshaping of the acoustic field. Our demonstrations illustrate the potential for achieving ultra-long storage times of individual pulses by several hundred pulse widths, marking a significant stride toward advancing the field of all-optical storage and delay mechanisms.

Mills, J, Gebhard, LJ, Schubotz, F, Shevchenko, A, Speth, DR, Liao, Y, Duggin, IG, Marchfelder, A & Erdmann, S 2024, 'Extracellular vesicle formation in Euryarchaeota is driven by a small GTPase', Proceedings of the National Academy of Sciences, vol. 121, no. 10.
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Since their discovery, extracellular vesicles (EVs) have changed our view on how organisms interact with their extracellular world. EVs are able to traffic a diverse array of molecules across different species and even domains, facilitating numerous functions. In this study, we investigate EV production in Euryarchaeota, using the model organism Haloferax volcanii . We uncover that EVs enclose RNA, with specific transcripts preferentially enriched, including those with regulatory potential, and conclude that EVs can act as an RNA communication system between haloarchaea. We demonstrate the key role of an EV-associated small GTPase for EV formation in H. volcanii that is also present across other diverse evolutionary branches of Archaea. We propose the name, ArvA, for the identified family of archaeal vesiculating GTPases. Additionally, we show that two genes in the same operon with arvA ( arvB and arvC ) are also involved in EV formation. Both, arvB and arvC , are closely associated with arvA in the majority of other archaea encoding ArvA. Our work demonstrates that small GTPases involved in membrane deformation and vesiculation, ubiquitous in Eukaryotes, are also present in Archaea and are widely distributed across diverse archaeal phyla.

Missen, OP, Mills, SJ, Thaise Moro, T, Villalobos-Portillo, EE, Castillo-Michel, H, Lockwood, TE, Gonzalez de Vega, R & Clases, D 2024, 'Natural cobalt–manganese oxide nanoparticles: speciation, detection and implications for cobalt cycling', Environmental Chemistry, vol. 21, no. 2.
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Mullens, BG, Marlton, FP, Nicholas, MK, Permana, AJ, Avdeev, M, Mukherjee, S, Vaitheeswaran, G, Li, C, Liu, J, Chater, PA & Kennedy, BJ 2024, 'Seeing the Unseen: The Structural Influence of the Lone Pair Electrons in PbWO₄', Inorganic Chemistry, vol. 63, no. 24, pp. 11176-11186.
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Mullens, BG, Marlton, FP, Saura-Múzquiz, M, Chater, PA & Kennedy, BJ 2024, 'Tetrahedra Rotational and Displacive Disorder in the Scheelite-Type Oxide CsReO₄', Inorganic Chemistry, vol. 63, no. 22, pp. 10386-10396.
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Mullens, BG, Saura-Múzquiz, M, Cordaro, G, Marlton, FP, Maynard-Casely, HE, Zhang, Z, Baldinozzi, G & Kennedy, BJ 2024, 'Variable Temperature In Situ Neutron Powder Diffraction and Conductivity Studies of Undoped HoNbO₄ and HoTaO₄', Chemistry of Materials, vol. 36, no. 10, pp. 5002-5016.
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Naeem, U, Zahra, SA, Ali, I, Li, H, Mahmood, A & Rizwan, S 2024, 'Unleashing the potential of NiO@V2CTx MXene-derived electrocatalyst for hydrogen and oxygen evolution', International Journal of Hydrogen Energy, vol. 59, pp. 635-644.
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Naghavi, M, Ong, KL, Aali, A, Ababneh, HS, Abate, YH, Abbafati, C, Abbasgholizadeh, R, Abbasian, M, Abbasi-Kangevari, M, Abbastabar, H, Abd ElHafeez, S, Abdelmasseh, M, Abd-Elsalam, S, Abdelwahab, A, Abdollahi, M, Abdollahifar, M-A, Abdoun, M, Abdulah, DM, Abdullahi, A, Abebe, M, Abebe, SS, Abedi, A, Abegaz, KH, Abhilash, ES, Abidi, H, Abiodun, O, Aboagye, RG, Abolhassani, H, Abolmaali, M, Abouzid, M, Aboye, GB, Abreu, LG, Abrha, WA, Abtahi, D, Abu Rumeileh, S, Abualruz, H, Abubakar, B, Abu-Gharbieh, E, Abu-Rmeileh, NME, Aburuz, S, Abu-Zaid, A, Accrombessi, MMK, Adal, TG, Adamu, AA, Addo, IY, Addolorato, G, Adebiyi, AO, Adekanmbi, V, Adepoju, AV, Adetunji, CO, Adetunji, JB, Adeyeoluwa, TE, Adeyinka, DA, Adeyomoye, OI, Admass, BAA, Adnani, QES, Adra, S, Afolabi, AA, Afzal, MS, Afzal, S, Agampodi, SB, Agasthi, P, Aggarwal, M, Aghamiri, S, Agide, FD, Agodi, A, Agrawal, A, Agyemang-Duah, W, Ahinkorah, BO, Ahmad, A, Ahmad, D, Ahmad, F, Ahmad, MM, Ahmad, S, Ahmad, S, Ahmad, T, Ahmadi, K, Ahmadzade, AM, Ahmed, A, Ahmed, A, Ahmed, H, Ahmed, LA, Ahmed, MS, Ahmed, MS, Ahmed, MB, Ahmed, SA, Ajami, M, Aji, B, Akara, EM, Akbarialiabad, H, Akinosoglou, K, Akinyemiju, T, Akkaif, MA, Akyirem, S, Al Hamad, H, Al Hasan, SM, Alahdab, F, Alalalmeh, SO, Alalwan, TA, Al-Aly, Z, Alam, K, Alam, M, Alam, N, Al-amer, RM, Alanezi, FM, Alanzi, TM, Al-Azzam, S, Albakri, A, Albashtawy, M, AlBataineh, MT, Alcalde-Rabanal, JE, Aldawsari, KA, Aldhaleei, WA, Aldridge, RW, Alema, HB, Alemayohu, MA, Alemi, S, Alemu, YM, Al-Gheethi, AAS, Alhabib, KF, Alhalaiqa, FAN, Al-Hanawi, MK, Ali, A, Ali, A, Ali, L, Ali, MU, Ali, R, Ali, S, Ali, SSS, Alicandro, G, Alif, SM, Alikhani, R, Alimohamadi, Y, Aliyi, AA, Aljasir, MAM, Aljunid, SM, Alla, F, Allebeck, P, Al-Marwani, S, Al-Maweri, SAA, Almazan, JU, Al-Mekhlafi, HM, Almidani, L, Almidani, O, Alomari, MA, Al-Omari, B, Alonso, J, Alqahtani, JS, Alqalyoobi, S, Alqutaibi, AY, Al-Sabah, SK, Altaany, Z, Altaf, A, Al-Tawfiq, JA, Altirkawi, KA, Aluh, DO, Alvis-Guzman, N, Alwafi, H, Al-Worafi, YM, Aly, H, Aly, S, Alzoubi, KH, Amani, R, Amare, AT, Amegbor, PM, Ameyaw, EK, Amin, TT, Amindarolzarbi, A, Amiri, S, Amirzade-Iranaq, MH, Amu, H, Amugsi, DA, Amusa, GA, Ancuceanu, R, Anderlini, D, Anderson, DB, Andrade, PP, Andrei, CL, Andrei, T, Angus, C, Anil, A, Anil, S, Anoushiravani, A, Ansari, H, Ansariadi, A & et al. 2024, 'Global burden of 288 causes of death and life expectancy decomposition in 204 countries and territories and 811 subnational locations, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021', The Lancet, vol. 403, no. 10440, pp. 2100-2132.
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Neuper, C, Šimić, M, Lockwood, TE, Gonzalez de Vega, R, Hohenester, U, Fitzek, H, Schlatt, L, Hill, C & Clases, D 2024, 'Optofluidic Force Induction Meets Raman Spectroscopy and Inductively Coupled Plasma-Mass Spectrometry: A New Hyphenated Technique for Comprehensive and Complementary Characterizations of Single Particles', Analytical Chemistry, vol. 96, no. 21, pp. 8291-8299.
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Neuteboom, W, Ross, A, Bugeja, L, Willis, S, Roux, C & Lothridge, K 2024, 'Quality Management in forensic science: A closer inspection', Forensic Science International, vol. 358, pp. 111779-111779.
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Nguyen, HM, Hong, UVT, Ruocco, M, Dattolo, E, Marín-Guirao, L, Pernice, M & Procaccini, G 2024, 'Thermo-priming triggers species-specific physiological and transcriptome responses in Mediterranean seagrasses', Plant Physiology and Biochemistry, vol. 210, pp. 108614-108614.
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Panthi, VK, Bashyal, S & Paudel, KR 2024, 'Docetaxel-loaded nanoformulations delivery for breast cancer management: Challenges, recent advances, and future perspectives', Journal of Drug Delivery Science and Technology, vol. 92, pp. 105314-105314.
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Parker, LM, Scanes, E, O'Connor, WA, Dove, M, Elizur, A, Pörtner, H-O & Ross, PM 2024, 'Resilience against the impacts of climate change in an ecologically and economically significant native oyster', Marine Pollution Bulletin, vol. 198, pp. 115788-115788.
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Passarelli, N, Palomba, S, Kabakova, I & de Sterke, CM 2024, 'Rational design of an integrated directional coupler for wideband operation', Applied Optics, vol. 63, no. 14, pp. D28-D28.
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We consider a design procedure for directional couplers for which the coupling length is approximately wavelength-independent over a wide bandwidth. We show analytically that two coupled planar waveguides exhibit a maximum in the coupling strength, which ensures both wideband transmission and minimal device footprint. This acts as a starting point for mapping out the relevant part of phase space. This analysis is then generalized to the fully three-dimensional geometry of rib waveguides using an effective medium approximation. This forms an excellent starting point for fully numerical calculations and leads to designs with unprecedented bandwidths and compactness.

Patel, VK, Kokkinis, S, De Rubis, G, Hansbro, PM, Paudel, KR & Dua, K 2024, 'CURCUMIN LIPOSOMES ATTENUATE THE EXPRESSION OF CIGARETTE SMOKE EXTRACT-INDUCED INFLAMMATORY MARKERS IL-8 AND IL-24 IN VITRO', EXCLI JOURNAL, vol. 23, pp. 904-907.
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Paudel, KR, Clarence, DD, Panth, N, Manandhar, B, De Rubis, G, Devkota, HP, Gupta, G, Zacconi, FC, Williams, KA, Pont, LG, Singh, SK, Warkiani, ME, Adams, J, MacLoughlin, R, Oliver, BG, Chellappan, DK, Hansbro, PM & Dua, K 2024, 'Zerumbone liquid crystalline nanoparticles protect against oxidative stress, inflammation and senescence induced by cigarette smoke extract in vitro', Naunyn-Schmiedeberg's Archives of Pharmacology, vol. 397, no. 4, pp. 2465-2483.
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AbstractThe purpose of this study was to evaluate the potential of zerumbone-loaded liquid crystalline nanoparticles (ZER-LCNs) in the protection of broncho-epithelial cells and alveolar macrophages against oxidative stress, inflammation and senescence induced by cigarette smoke extract in vitro. The effect of the treatment of ZER-LCNs on in vitro cell models of cigarette smoke extract (CSE)-treated mouse RAW264.7 and human BCi-NS1.1 basal epithelial cell lines was evaluated for their anti-inflammatory, antioxidant and anti-senescence activities using colorimetric and fluorescence-based assays, fluorescence imaging, RT-qPCR and proteome profiler kit. The ZER-LCNs successfully reduced the expression of pro-inflammatory markers including Il-6, Il-1β and Tnf-α, as well as the production of nitric oxide in RAW 264.7 cells. Additionally, ZER-LCNs successfully inhibited oxidative stress through reduction of reactive oxygen species (ROS) levels and regulation of genes, namely GPX2 and GCLC in BCi-NS1.1 cells. Anti-senescence activity of ZER-LCNs was also observed in BCi-NS1.1 cells, with significant reductions in the expression of SIRT1, CDKN1A and CDKN2A. This study demonstrates strong in vitro anti-inflammatory, antioxidative and anti-senescence activities of ZER-LCNs paving the path for this formulation to be translated into a promising therapeutic agent for chronic respiratory inflammatory conditions including COPD and asthma.

Paudel, KR, Mohamad, MSB, De Rubis, G, Reyes, R-J, Panth, N, Dureja, H, Gupta, G, Singh, SK, Madheswaran, T, Collet, T, Hansbro, PM, Dua, K & Chellappan, DK 2024, '18-β-Glycyrrhetinic acid encapsulated PLGA nanoparticles attenuate lung cancer proliferation and migration', Journal of Drug Delivery Science and Technology, vol. 95, pp. 105523-105523.
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Paudel, KR, Singh, M, De Rubis, G, Kumbhar, P, Mehndiratta, S, Kokkinis, S, El-Sherkawi, T, Gupta, G, Singh, SK, Malik, MZ, Mohammed, Y, Oliver, BG, Disouza, J, Patravale, V, Hansbro, PM & Dua, K 2024, 'Computational and biological approaches in repurposing ribavirin for lung cancer treatment: Unveiling antitumorigenic strategies', Life Sciences, pp. 122859-122859.
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Perveen, S, Padula, MP, Safdar, N & Abbas, S 2024, 'Functional annotation of proteins in Catharanthus roseus shoot cultures under biogenic zinc nanotreatment', Plant Molecular Biology, vol. 114, no. 2.
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Pham, NHT, Joglekar, MV, Wong, WKM, Nassif, NT, Simpson, AM & Hardikar, AA 2024, 'Short-chain fatty acids and insulin sensitivity: a systematic review and meta-analysis', Nutrition Reviews, vol. 82, no. 2, pp. 193-209.
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Abstract Context There is substantial evidence that reduced short-chain fatty acids (SCFAs) in the gut are associated with obesity and type 2 diabetes, although findings from clinical interventions that can increase SCFAs are inconsistent. Objective This systematic review and meta-analysis aimed to assess the effect of SCFA interventions on fasting glucose, fasting insulin, and homeostatic model assessment of insulin resistance (HOMA-IR). Data Sources Relevant articles published up to July 28, 2022, were extracted from PubMed and Embase using the MeSH (Medical Subject Headings) terms of the defined keywords [(short-chain fatty acids) AND (obesity OR diabetes OR insulin sensitivity)] and their synonyms. Data analyses were performed independently by two researchers who used the Cochrane meta-analysis checklist and the PRISMA guidelines. Data Extraction Clinical studies and trials that measured SCFAs and reported glucose homeostasis parameters were included in the analysis. Standardized mean differences (SMDs) with 95%CIs were calculated using a random-effects model in the data extraction tool Review Manager version 5.4 (RevMan 5.4). The risk-of-bias assessment was performed following the Cochrane checklist for randomized and crossover studies. Data Analysis In total, 6040 nonduplicate studies were identified, 23 of which me...

Picci, G, Montis, R, Gilchrist, AM, Gale, PA & Caltagirone, C 2024, 'Fluorescent and colorimetric sensors for anions: Highlights from 2020 to 2022', Coordination Chemistry Reviews, vol. 501, pp. 215561-215561.
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Pierce, JE, OHalloran, R, Togher, L, Nickels, L, Copland, D, Godecke, E, Meinzer, M, Rai, T, Cadilhac, DA, Kim, J, Hurley, M, Foster, A, Carragher, M, Wilcox, C, Steel, G & Rose, ML 2024, 'Acceptability, feasibility and preliminary efficacy of low-moderate intensity Constraint Induced Aphasia Therapy and Multi-Modality Aphasia Therapy in chronic aphasia after stroke', Topics in Stroke Rehabilitation, vol. 31, no. 1, pp. 44-56.
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Qashlan, A, Nanda, P & Mohanty, M 2024, 'Differential privacy model for blockchain based smart home architecture', Future Generation Computer Systems, vol. 150, pp. 49-63.
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Qian, C, Zhou, Y, Zhang, T, Dong, G, Song, M, Tang, Y, Wei, Z, Yu, S, Shen, Q, Chen, W, Choi, JP, Yan, J, Zhong, C, Wan, L, Li, J, Wang, A, Lu, Y & Zhao, Y 2024, 'Targeting PKM2 signaling cascade with salvianic acid A normalizes tumor blood vessels to facilitate chemotherapeutic drug delivery', Acta Pharmaceutica Sinica B, vol. 14, no. 5, pp. 2077-2096.
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Qiao, L, Li, M, Cui, Y, Xu, S, Reimers, JR & Ren, W 2024, 'Giant Carrier Mobility in a Room-Temperature Ferromagnetic VSi₂N₄ Monolayer', Nano Letters, vol. 24, no. 21, pp. 6403-6409.
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Using density functional theory (DFT), we investigate that two possible phases of VSi2N4 (VSN) may be realized, one called the 'H phase' corresponding to what is known from calculation and herein the other new 'T phase' being stabilized by a biaxial tensile strain of 3%. Significantly, the H phase is predicted to display a giant carrier mobility of 1 × 106 cm2 V-1 s-1, which exceeds that for most 2D magnetic materials, with a Curie temperature (TC) exceeding room temperature and a band gap of 2.01 eV at the K point. Following the H-T phase transition, the direct band gap shifts to the Γ point and increases to 2.59 eV. The Monte Carlo (MC) simulations also indicate that TC of the T phase VSN can be effectively modulated by strain, reaching room temperature under a biaxial strain of -4%. These results show that VSN should be a promising functional material for future nanoelectronics.

Quan, X, Chen, R, Yebra, M, Riaño, D, Resco de Dios, V, Li, X, He, B, Nolan, RH, Griebel, A, Boer, MM & Sun, Y 2024, 'Sub-daily live fuel moisture content estimation from Himawari-8 data', Remote Sensing of Environment, vol. 308, pp. 114170-114170.
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Quinteros, SL, Snyder, NW, Chatoff, A, Ryan, F, O'Brien, B & Donnelly, S 2024, 'The helminth‐derived peptide, FhHDM‐1, reverses the trained phenotype of NOD bone‐marrow‐derived macrophages and regulates proinflammatory responses', European Journal of Immunology, vol. 54, no. 6.
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Rahman, MK, Umashankar, B, Choucair, H, Bourget, K, Rawling, T & Murray, M 2024, 'The inositol-requiring enzyme 1 (IRE1) endoplasmic reticulum stress pathway promotes MDA-MB-231 cell survival and renewal in response to the aryl-ureido fatty acid CTU', The International Journal of Biochemistry & Cell Biology, vol. 171, pp. 106571-106571.
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REDMOND, G, MAIN, G, O’DONNELL, AW, SKATTEBOL, J, WOODMAN, R, MOONEY, A, WANG, J, TURKMANI, S, THOMSON, C & BROOKS, F 2024, 'Who excludes? Young People’s Experience of Social Exclusion', Journal of Social Policy, vol. 53, no. 1, pp. 236-259.
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AbstractExisting policy research has not comprehensively examined the processes by which young people experience social exclusion: that is, the relationships among different risk factors for exclusion, their actual experiences of exclusion, and outcomes that matter for their life chances. Drawing on data from a survey of Australian 13-14 year olds (N=3,535), this paper adapts the Bristol Social Exclusion Matrix to examine pathways from young people’s personal and family resources, their experience of participation (school engagement; bullying victimization; teacher support), and their life satisfaction – a predictive indicator of wellbeing and mental health in adulthood. The effects of other characteristics or risk factors for young people’s social exclusion (living with disability, being a young carer, identifying as Indigenous, and speaking a language other than English at home), are also examined. This paper shows that experience of exclusion mediates the relationship between young people’s personal and family resources and life satisfaction. Controlling for characteristics or risk factors does not change this relationship, suggesting that processes of social exclusion, enacted in interpersonal encounters, are driven by overarching structural factors. These findings are relevant for policy in Australia, and in other countries with similar policy regimes.

Rennie, C, Sives, C, Boyton, I, Diaz, D, Gorrie, C, Vittorio, O, Collins‐Praino, L & Care, A 2024, 'In Vivo Behavior of Systemically Administered Encapsulin Protein Nanocages and Implications for their use in Targeted Drug Delivery', Advanced Therapeutics, vol. 7, no. 2.
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AbstractEncapsulins, self‐assembling protein nanocages derived from prokaryotes, are promising nanoparticle‐based drug delivery systems (NDDS). However, the in vivo behavior and fate of encapsulins are poorly understood. In this study, the interactions between the model encapsulin from Thermotoga maritima (TmEnc) and key biological barriers encountered by NDDS are probed. Here, a purified TmEnc formulation that exhibits colloidal stability, storability, and blood compatibility is intravenously injected into BALB/c mice. TmEnc has an excellent nanosafety profile, with no abnormal weight loss or gross pathology observed, and only temporary alterations in toxicity biomarkers are detected. Notably, TmEnc demonstrates immunogenic properties, inducing the generation of nanocage‐specific IgM and IgG antibodies, but without any prolonged pro‐inflammatory effects. An absence of antibody cross‐reactivity also suggests immune‐orthogonality among encapsulin systems. Moreover, TmEnc forms a serum‐derived protein corona on its surface which changes dynamically and appears to play a role in immune recognition. TmEnc's biodistribution profile further reveals its sequestration from the blood circulation by the liver and then biodegrades within Kupffer cells, thus indicating clearance via the mononuclear phagocyte system. Collectively, these findings provide critical insights into how encapsulins behave in vivo, thereby informing their future design, modification, and application in targeted drug delivery.

Rennie, C, Sives, C, Boyton, I, Diaz, D, Gorrie, C, Vittorio, O, Collins‐Praino, L & Care, A 2024, 'In Vivo Behavior of Systemically Administered Encapsulin Protein Nanocages and Implications for their use in Targeted Drug Delivery (Adv. Therap. 2/2024)', Advanced Therapeutics, vol. 7, no. 2.
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Rigg, AL, Bellotto, C, Fowler, AM & Booth, DJ 2024, 'Staining protocols affect use of otolith to estimate the demography of the damselfish sergeant major (Abudefduf vaigiensis)', Journal of Fish Biology, vol. 104, no. 3, pp. 878-882.
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AbstractThis study assessed the otolith (sagittae, lapilli, and asterisci) increment deposition rate in the range‐shifting damselfish, A. vaigiensis, using different concentrations of Alizain Red S and evaluated the impact of staining on increment width. Daily increment deposition was verified in all otolith types and presented clearer fluorescent markings in the lapilli and sagittae than the asterisci, with high stain concentration showing the best clarity. Higher stain concentrations were found to decrease increment width, suggesting care is needed when using stained otoliths as a proxy for growth for this species.

Ritchie, RJ, Sma-Air, S, Johnson, MS, Murray, SA, Nguyen, A, Larkum, AWD & Dummee, V 2024, 'Photosynthesis in a green alga (zoochlorella), Chlorella cf. vulgaris in the soft coral Sarcophyton sp.', Phycologia, vol. 63, no. 1, pp. 60-73.
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Roy Chowdhury, P, Alhamami, T, Venter, H, Veltman, T, Carr, M, Mollinger, J, Trott, DJ & Djordjevic, SP 2024, 'Identification and evolution of ICE-PmuST394: a novel integrative conjugative element in Pasteurella multocida ST394', Journal of Antimicrobial Chemotherapy, vol. 79, no. 4, pp. 851-858.
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Abstract Background The emergence of macrolide and tetracycline resistance within Pasteurella multocida isolated from feedlot cattle and the dominance of ST394 in Australia was reported recently. Objectives To establish the genetic context of the resistance genes in P. multocida 17BRD-035, the ST394 reference genome, and conduct a molecular risk assessment of their ability to disperse laterally. Methods A bioinformatic analysis of the P. multocida 17BRD-035 genome was conducted to determine if integrative conjugative elements (ICEs) carrying resistance genes, which hamper antibiotic treatment options locally, are in circulation in Australian feedlots. Results A novel element, ICE-PmuST394, was characterized in P. multocida 17BRD-035. It was also identified in three other isolates (two ST394s and a ST125) in Australia and is likely present in a genome representing P. multocida ST79 from the USA. ICE-PmuST394 houses a resistance module carrying two variants of the blaROB gene, blaROB-1 and blaROB-13, and the macrolide esterase gene, estT. The resistance gene combination on ICE-PmuST394 confers resistance to ampicillin and tilmicosin, but not to tulathromycin and tildipirosin. Our analysis suggests that ICE-PmuST394 is circulating both by clonal expansion and horizontal transfer but is currently restricted to a single feedlot in Australia. Conclusions

Roy, R, Chick, P, York, E & Rawling, T 2024, 'Cytotoxicity of acridinium-based ionic liquids: Structure-activity relationship and mechanistic studies', Chemico-Biological Interactions, vol. 396, pp. 111042-111042.
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Roy, R, York, E, Pacchini, E & Rawling, T 2024, 'Effects of cationic head group structure on cytotoxicity and mitochondrial actions of amphiphilic ionic liquids', Food and Chemical Toxicology, vol. 183, pp. 114202-114202.
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Ionic liquids (ILs) are a class of low melting point salts with physicochemical properties that make them suitable for a range of industrial applications. Accumulating evidence suggests that certain ILs are cytotoxic and potential environmental pollutants, thus understanding the structural features that promote IL cytotoxicity is important. Amphiphilic ionic liquids (AmILs), a class of ILs with lipophilic N-alkyl chains, containing aromatic head groups are generally more cytotoxic than their aliphatic counterparts, however the impact of other head group properties are less clear. This study therefore sought to provide new structure activity relationship (SAR) insights regarding the role of the cationic head group on AmIL cytotoxicity. A series of AmILs bearing a range of structurally diverse aromatic cations varying in size, charge, and lipophilicity was synthesised and screened against human MDA-MB-231 breast cancer cells. It was found that larger and more lipophilic head groups increased cytotoxicity, although the magnitude of the changes were modest. The mitochondrial effects of representative ILs were assessed. The AmILs induced mitochondrial dysfunction in MDA-MB-231 cells at cytotoxic concentrations, suggesting that they target mitochondria. The new SAR information from this study may assist in the design of AmILs with controlled cytotoxicity.

Ruvindy, R, Ajani, PA, Ashlin, S, Hallegraeff, G, Klemm, K, Bolch, CJ, Ugalde, S, Van Asten, M, Woodcock, S, Tesoriero, M & Murray, SA 2024, 'An On-Farm Workflow for Predictive Management of Paralytic Shellfish Toxin-Producing Harmful Algal Blooms for the Aquaculture Industry', Environmental Science & Technology, vol. 58, no. 16, pp. 6924-6933.
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Sadraeian, M, Kabakova, I, Zhou, J & Jin, D 2024, 'Virus inactivation by matching the vibrational resonance', Applied Physics Reviews, vol. 11, no. 2.
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Physical approaches based on irradiation provide advances for the prevention and treatment of viral infections, while recognizing that certain chemical inactivation techniques demonstrate significant effectiveness alongside physical methods. By generating resonant vibrations of complete virus particles, which are in the GHz range and quite high compared to that of human cells, viruses can be inactivated. Therefore, exposure to ultrasound waves or non-thermal microwaves with a suitable resonant frequency oscillating electric field holds the potential to neutralize the virus particle with no damage to human. The deactivation mechanism could be a result of the mechanical effect or oxidation stress, and in this article, we discuss the elucidation of these effects on the virus' structure. We also explore the current state and future prospects of the anti-viral methods based on acoustic cavitation via ultrasound and non-thermal microwave, addressing critical needs in virology.

Salih, AK, Aditya, L, Matar, F, Nghiem, LD & Ton-That, C 2024, 'Improved flux and anti-fouling performance of a photocatalytic ZnO membrane on porous stainless steel substrate for microalgae harvesting', Journal of Membrane Science, vol. 694, pp. 122405-122405.
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Scanes, E, Kutti, T, Fang, JKH, Johnston, EL, Ross, PM & Bannister, RJ 2024, 'The long-lived deep-sea bivalve Acesta excavata is sensitive to the dual stressors of sediment and warming', Marine Pollution Bulletin, vol. 202, pp. 116323-116323.
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Scardifield, K, McLean, N, Kuzhiumparambil, U, Ralph, PJ, Neveux, N, Isaac, G & Schork, T 2024, 'Biomasonry products from macroalgae: A design driven approach to developing biomaterials for carbon storage', Journal of Applied Phycology, vol. 36, no. 2, pp. 935-950.
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AbstractLowering the embodied carbon of building materials requires a transition away from fossil derived products towards bio-based alternatives, alongside the design and development of new clean tech biomaterials that can function as carbon sinks. This paper presents an overview of historical and existing uses of seaweeds in construction to identify gaps and opportunities for the development of seaweed-based construction materials that can support atmospheric carbon removal through algal photosynthesis. This study highlights the value of interdisciplinary research collaborations that can be situated within the expanding field of biodesign where design research and methods are used to influence the development materials science. It presents as a case study the design of seaweed bricks utilising a biorefinery framework that aims to valorise residual seaweed biomass being grown for waste-water management, identifying value-adding opportunities for this seaweed by-product and new possibilities for carbon storage in the built environment. It details the development of a 1:1 scale prototype for the purposes of an exhibition at the Art Gallery of South Australia in order to demonstrate what biomasonry products from macroalgae can look like, to build social acceptance and to encourage future uptake of sustainable seaweed construction products.

Schlotheuber, M, Voolstra, CR, de Beer, D, Camp, EF, Klatt, JM, Ghilardi, M, Neumüller, K, Ousley, S & Bejarano, S 2024, 'High temporal resolution of hydrogen peroxide (H2O2) dynamics during heat stress does not support a causative role in coral bleaching', Coral Reefs, vol. 43, no. 1, pp. 119-133.
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AbstractHuman-induced climate change is causing ocean warming that triggers the breakdown of the coral–algal symbiosis. The proximate cause of this phenomenon, known as coral bleaching, is commonly attributed to the overproduction of reactive oxygen species (ROS) by the thermally stressed photosynthetic algal symbionts. However, direct evidence that algal ROS production (e.g., in the form of H2O2) and coral physiological stress are the ultimate cause of bleaching remains ambiguous. Here, we investigated the temporal dynamics of H2O2 and oxygen (O2) concentrations during thermally induced coral bleaching to disentangle cause from consequence. Microsensors at the tissue interface of Pocillopora damicornis measured H2O2 and O2 concentrations while exposing single nubbins to baseline temperatures (30 °C) and to minor (33 °C), moderate (36 °C), and high (39 °C) levels of acute heat stress using the Coral Bleaching Automated Stress System (CBASS). We show that a temporary decline in O2 concentration, accompanied by a declining photosynthetic efficiency and loss of Symbiodiniaceae and pigmentation, is the initial response to moderate thermal stress. This response was neither provoked nor followed by an increased H2O2 concentration at the coral tissue interface. A steady light-independent increase of H2O2 was only detected during high heat stress, resulting in the complete and permanent loss of photosynthetic activity. Our findings do not support a direct connection between algal photodamage and an increase in H2O2 concentration during thermally induced bleaching and suggest that more research...

Scognamiglio, D, Gale, A, Al-Juboori, A, Toth, M & Aharonovich, I 2024, 'On-demand quantum light sources for underwater communications', Materials for Quantum Technology, vol. 4, no. 2, pp. 025402-025402.
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Abstract Quantum communication has been at the forefront of modern research for decades, however it is severely hampered in underwater applications, where the properties of water absorb nearly all useful optical wavelengths and prevent them from propagating more than, in most cases, a few metres. This research reports on-demand quantum light sources, suitable for underwater optical communication. The single photon emitters, which can be engineered using an electron beam, are based on impurities in hexagonal boron nitride. They have a zero phonon line at ∼436 nm, near the minimum value of water absorption and are shown to suffer negligible transmission and purity loss when travelling through water channels. These emitters are also shown to possess exceptional underwater transmission properties compared to emitters at other optical wavelengths and are utilised in a completely secure quantum key distribution experiment with rates of kbits s−1.

Scott, RI, Edmondson, J, Camp, EF, Agius, T, Coulthard, P, Edmondson, J, Edmondson, K, Hosp, R, Howlett, L, Roper, CD & Suggett, DJ 2024, 'Cost‐effectiveness of tourism‐led coral planting at scale on the northern Great Barrier Reef', Restoration Ecology, vol. 32, no. 4.
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Stakeholder‐led coral reef restoration efforts, aimed at locally retaining or rebuilding coral populations, have rapidly grown over the last two decades. However, the cost‐effectiveness—and in turn viability—of coral restoration projects remains rarely reported. We therefore evaluated coral planting (often termed “outplanting”) cost‐effectiveness across the first 3.5 years of the Coral Nurture Program (CNP), a coral restoration approach integrated within tourism operations on Australia's Great Barrier Reef. CNP operator activity reporting forms (63,632 corals planted, 5 tourism operators, and 23 reef sites) were used to opportunistically calculate coral planting costs (PC; US$ coral−1 trip−1) for “routine” planting versus when additional stewardship activities—that regulate planting effectiveness—were undertaken (e.g., nursery maintenance). Mean PC (±standard error) was US$2.34 ± 0.20 coral−1 trip−1 (ranging US$0.78–6.03, 5th–95th percentile), but increased 2‐ to ‐6‐fold on trips where nursery propagation, site maintenance, or staff training was conducted to support planting efforts. The “realized” cost (PCR) of establishing coral biomass was subsequently determined by evaluating survivorship of planted corals across space (9 sites, single survey timepoint, n = 4,723 corals up to 3 years old) or over time (2 sites, over 9–12 months, n = 600 corals), resulting in costs increasing from PC to PCR by 25–71%. We demonstrate how integration of practices into tourism operations creates potential for cost‐effective coral planting at “high‐value” tourism reef sites, and discuss important steps for improving cost‐accounting in stakeholder‐led restoration programs that may be similarly positioned to routinely determine their cost‐effectiveness.

Seymour, JR, Brumley, DR, Stocker, R & Raina, J-B 2024, 'Swimming towards each other: the role of chemotaxis in bacterial interactions', Trends in Microbiology.
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Siboni, N, King, WL, Williams, NLR, Scanes, E, Giardina, M, Green, TJ, Ostrowski, M, O'Connor, W, Dove, M, Labbate, M & Seymour, JR 2024, 'Increased abundance of potentially pathogenic Vibrio and a marine heatwave co-occur with a Pacific Oyster summer mortality event', Aquaculture, vol. 583, pp. 740618-740618.
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Siddique, MAB, Imran, M, Haider, A, Shahzadi, A, Ul-Hamid, A, Nabgan, W, Batool, M, Khan, K, Ikram, M, Somaily, HH & Mahmood, A 2024, 'Enhancing catalytic and antibacterial activity with size-controlled yttrium and graphene quantum dots doped MgO nanostructures: A molecular docking analysis', Materials Today Sustainability, vol. 25, pp. 100690-100690.
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Sim, DZH, Mowe, MAD, Mitrovic, SM, Tulsian, NK, Anand, GS & Yeo, DCJ 2024, 'Nutrient conditions influence allelopathic capabilities of Ludwigia adscendens and other tropical macrophytes against Microcystis aeruginosa', Freshwater Biology, vol. 69, no. 4, pp. 538-555.
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AbstractMacrophytes may release allelochemicals that suppress competing phytoplankton, although it is unclear how their effectiveness could be influenced by environmental nutrient conditions. To approach this, we conducted a series of bioassays against the bloom‐forming cyanobacterium Microcystis aeruginosa using extracts and exudates from potentially allelopathic macrophytes under varying nutrient conditions.We screened six different tropical macrophytes and identified antialgal effects in both extracts and exudates of Ludwigia adscendens, Persicaria barbata, Pontederia crassipes and Vallisneria spiralis. Growth assays indicated that extract inhibitory effectiveness decreased as nutrient concentration increased from 5% to 50% strength.Focusing on the potent antialgal extract of L. adscendens, we determined that its inhibitory effects were enhanced by specifically reducing the availability of either micronutrient or bicarbonate availability, indicating a role of these nutrients in protecting algal cells from allelochemicals.Bioactivity‐guided fractionation and ultra‐performance liquid chromatography – mass spectrometry analyses of L. adscendens extract indicated that ellagitannins were the major constituent of bioactive extract fractions, suggesting an antialgal mechanism common to other tannic compounds. Novel allelopathic alkaloids and terpenoid compounds also were described, although their mechanisms of action are unknown.Our findings provide evidence that the availability of carbon and micr...

Singh, M, De Rubis, G, Kokkinis, S, Paudel, KR, Yeung, S, Hansbro, PM, Oliver, BGG & Dua, K 2024, 'Curcumin-loaded liposomes modulating the synergistic role of EpCAM and estrogen receptor alpha in lung cancer management', Pathology - Research and Practice, vol. 257, pp. 155317-155317.
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Singh, S, Saxena, S, Sharma, H, Paudel, KR, Chakraborty, A, MacLoughlin, R, Oliver, BG, Gupta, G, Negi, P, Singh, SK & Dua, K 2024, 'Emerging role of tumor suppressing microRNAs as therapeutics in managing non-small cell lung cancer', Pathology - Research and Practice, vol. 256, pp. 155222-155222.
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Sofian, M, Nasim, F, Ali, H, Kanodarwala, FK & Nadeem, MA 2024, 'Efficient formic acid oxidation over gallium oxide incorporated Pd containing electrocatalyst', International Journal of Hydrogen Energy, vol. 51, pp. 1277-1285.
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Solanki, N, Gupta, G, Chellappan, DK, Singh, SK, Gulati, M, Paudel, KR, Hansbro, PM, Dua, K, Bhan, S, Saini, M & Dureja, H 2024, 'Boswellic Acids: A Critical Appraisal of Their Therapeutic and Nutritional Benefits in Chronic Inflammatory Diseases', Endocrine, Metabolic & Immune Disorders - Drug Targets, vol. 24, no. 1, pp. 116-129.
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Background:In the last few decades, it has been largely perceived that the factors affecting the immune system and its varying pathways lead to the pathological progression of inflammation and inflammatory conditions. Chronic inflammation also contributes to common diseases, such as diabetes mellitus, ischemic heart disease, cancer, chronic renal inflammatory disease, non-alcoholic fatty hepat-ic disease, autoimmune diseases and neurodegenerative diseases.Objective:Interestingly, plant sources and secondary metabolites from plants have been increasingly employed in managing acute and chronic inflammatory diseases for centuries. Boswellic acids are pentacyclic triterpenoidal moieties obtained from the oleo gum resin of different Boswellia species.Methods:Detailed data was collected revealing the anti-inflammatory potential of Boswellic acids through various databases.Results:These are pharmacologically active agents that possess promising anti-inflammatory, anti-arthritic, antirheumatic, anti-diarrheal, anti-hyperlipidemic, anti-asthmatic, anti-cancer, and anti-microbial effects.Conclusion:Boswellic acids have been in use since ancient times primarily to treat acute and chronic inflammatory diseases. This review discusses the various mechanisms underlying the inflammatory process and the necessity of such natural products as a medication to treat inflammatory diseases. In addition, a discussion has also been extended to understand the primary targets involved in inflamma-tion. The review further explores the therapeutic potential of boswellic acids in

Spina, N, Raimondi, M, Castorina, A, Ragonese, E & Palmisano, G 2024, 'A Three-Channel Package-Scale Galvanic Isolation Interface for Wide Bandgap Gate Drivers', IEEE Transactions on Very Large Scale Integration (VLSI) Systems, pp. 1-11.
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Strader, ME, Wright, RM, Pezner, AK, Nuttall, MF, Aichelman, HE & Davies, SW 2024, 'Intersection of coral molecular responses to a localized mortality event and ex situ deoxygenation', Ecology and Evolution, vol. 14, no. 4.
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AbstractIn July 2016, East Bank of Flower Garden Banks (FGB) National Marine Sanctuary experienced a localized mortality event (LME) of multiple invertebrate species that ultimately led to reductions in coral cover. Abiotic data taken directly after the event suggested that acute deoxygenation contributed to the mortality. Despite the large impact of this event on the coral community, there was no direct evidence that this LME was driven by acute deoxygenation, and thus we explored whether gene expression responses of corals to the LME would indicate what abiotic factors may have contributed to the LME. Gene expression of affected and unaffected corals sampled during the mortality event revealed evidence of the physiological consequences of the LME on coral hosts and their algal symbionts from two congeneric species (Orbicella franksi and Orbicella faveolata). Affected colonies of both species differentially regulated genes involved in mitochondrial regulation and oxidative stress. To further test the hypothesis that deoxygenation led to the LME, we measured coral host and algal symbiont gene expression in response to ex situ experimental deoxygenation (control = 6.9 ± 0.08 mg L−1, anoxic = 0.083 ± 0.017 mg L−1) in healthy O. faveolata colonies from the FGB. However, this deoxygenation experiment revealed divergent gene expression patterns compared to the corals sampled during the LME and was more similar to a generalized coral environmental stress response. It is therefore likely that while the LME was connected to low oxygen, it was a series of interconnected stressors that elicited the unique gene expression responses observed here. These in situ and ex situ data highlight how field responses to stressors are unique from those in controlled laboratory conditions, and that the complexities of deoxy...

Strange, N, Luu, L, Ong, V, Wee, BA, Phillips, MJA, McCaughey, L, Steele, JR, Barlow, CK, Cranfield, CG, Myers, G, Mazraani, R, Rock, C, Timms, P & Huston, WM 2024, 'HtrA, fatty acids, and membrane protein interplay in Chlamydia trachomatis to impact stress response and trigger early cellular exit', Journal of Bacteriology, vol. 206, no. 4.
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ABSTRACT Chlamydia trachomatis is an intracellular bacterial pathogen that undergoes a biphasic developmental cycle, consisting of intracellular reticulate bodies and extracellular infectious elementary bodies. A conserved bacterial protease, HtrA, was shown previously to be essential for Chlamydia during the reticulate body phase, using a novel inhibitor (JO146). In this study, isolates selected for the survival of JO146 treatment were found to have polymorphisms in the acyl-acyl carrier protein synthetase gene ( aasC ) . AasC encodes the enzyme responsible for activating fatty acids from the host cell or synthesis to be incorporated into lipid bilayers. The isolates had distinct lipidomes with varied fatty acid compositions. A reduction in the lipid compositions that HtrA prefers to bind to was detected, yet HtrA and MOMP (a key outer membrane protein) were present at higher levels in the variants. Reduced progeny production and an earlier cellular exit were observed. Transcriptome analysis identified that multiple genes were downregulated in the variants especially stress and DNA processing factors. Here, we have shown that the fatty acid composition of chlamydial lipids, HtrA, and membrane proteins interplay and, when disrupted, impact chlamydial stress response that could trigger early cellular exit. IMPORTANCE Chlamydia trachomatis is an important obligate intracellular pathogen that has a unique biphasic developmental cycle. HtrA is an essential stress or virulence...

Strudwick, P, Camp, EF, Seymour, J, Roper, C, Edmondson, J, Howlett, L & Suggett, DJ 2024, 'Impacts of plastic‐free materials on coral‐associated bacterial communities during reef restoration', Environmental Microbiology Reports, vol. 16, no. 1.
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AbstractCoral propagation and out‐planting based restoration approaches are increasingly being applied to assist natural recovery of coral reefs. However, many restoration methods rely on plastic zip‐ties to secure coral material which is potentially problematic for the marine environment. Plastic‐free biodegradable alternatives may however pose unique risks to coral‐associated bacterial communities integral to coral health. Therefore, to identify whether biodegradable materials differentially impact coral‐associated bacterial communities we examined Acropora millepora coral‐associated bacterial communities during propagation in two experiments on the Great Barrier Reef. Coral fragments were secured to coral nurseries with conventional plastic, metal, or biodegradable (polyester and polycaprolactone) ties. Tie failure and coral‐associated bacterial communities were then characterized over six months. Minimal coral mortality was observed (3.6%–8%) and all ties had low failure rates (0%–4.2%) except for biodegradable polyester ties (29.2% failure). No differences were observed between coral‐associated bacterial communities of fragments secured with different ties, and no proliferation of putatively pathogenic bacteria was recorded. Overall, our findings suggest that reducing reliance on conventional plastic is feasible through transitions to biodegradable materials, without any notable impacts on coral‐associated bacterial communities. However, we caution the need to examine more coral taxa of different morphologies and new plastic‐free materials prior to application.

Stuart, B, Frankham, GJ, Mangion, G & Ueland, M 2024, 'A rapid and non-destructive identification method for tortoiseshell products using attenuated total reflectance infrared spectroscopy', Forensic Science International: Animals and Environments, vol. 5, pp. 100079-100079.
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Stuart, B, Guan, J, Collins, S, Thomas, P & Ueland, M 2024, 'A preliminary study of non-woven fabrics for forensic identification purposes', Australian Journal of Forensic Sciences, vol. 56, no. 2, pp. 144-153.
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While traditional woven textiles have been the subject of many forensic investigations, non-woven fabrics have received minimal attention thus far. Given the expansion of commercial applications of non-woven fabrics, a preliminary investigation of household wipes has been carried out to characterize the compositions of these widely available non-woven fabrics. Infrared spectroscopy and thermogravimetric analysis were employed to identify the fibre type and additives of three types of commercial wipes. Polyester and/or viscose fibres were found to be the main components and, along with the identification of binders, enable source types to be differentiated. The predicted different sensitivities of the fibre types to biodeterioration highlights the importance of future environmental studies for the correct characterization of non-woven fabrics in evidence.

Stylianou, N, Sebina, I, Matigian, N, Monkman, J, Doehler, H, Röhl, J, Allenby, M, Nam, A, Pan, L, Rockstroh, A, Sadeghirad, H, Chung, K, Sobanski, T, O'Byrne, K, Almeida, ACSF, Rebutini, PZ, Machado‐Souza, C, Stonoga, ETS, Warkiani, ME, Salomon, C, Short, K, McClements, L, de Noronha, L, Huang, R, Belz, GT, Souza‐Fonseca‐Guimaraes, F, Clifton, V & Kulasinghe, A 2024, 'Whole transcriptome profiling of placental pathobiology in SARS‐CoV‐2 pregnancies identifies placental dysfunction signatures', Clinical & Translational Immunology, vol. 13, no. 2.
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AbstractObjectivesSevere Acute Respiratory Syndrome Coronavirus 2 (SARS‐CoV‐2) virus infection in pregnancy is associated with higher incidence of placental dysfunction, referred to by a few studies as a ‘preeclampsia‐like syndrome’. However, the mechanisms underpinning SARS‐CoV‐2‐induced placental malfunction are still unclear. Here, we investigated whether the transcriptional architecture of the placenta is altered in response to SARS‐CoV‐2 infection.MethodsWe utilised whole‐transcriptome, digital spatial profiling, to examine gene expression patterns in placental tissues from participants who contracted SARS‐CoV‐2 in the third trimester of their pregnancy (n = 7) and those collected prior to the start of the coronavirus disease 2019 (COVID‐19) pandemic (n = 9).ResultsThrough comprehensive spatial transcriptomic analyses of the trophoblast and villous core stromal cell subpopulations in the placenta, we identified SARS‐CoV‐2 to promote signatures associated with hypoxia and placental dysfunction. Notably, genes associated with vasodilation (NOS3), oxidative stress (GDF15, CRH) and preeclampsia (FLT1, EGFR, KISS1, PAPPA2) were enriched with SARS‐CoV‐2. Pathways related to increased nutrient uptake, vascular tension, hypertension and inflammation were also enriched in SARS‐CoV‐2 samples compared to uninfected controls.ConclusionsOur findings demonstrate the utility of spatially resolved transcriptomic analysis in defining the underlying pathogenic mechanisms of S...

Su, F, Chen, S, Liu, Y, Zhou, J, Du, Z, Luo, X, Wen, S & Jin, D 2024, 'Lanthanide Complex for Single-Molecule Fluorescent in Situ Hybridization and Background-Free Imaging', Analytical Chemistry, vol. 96, no. 11, pp. 4430-4436.
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Sullivan, E, Zeki, R, Ward, S, Sherwood, J, Remond, M, Chang, S, Kypri, K & Brown, J 2024, 'Effects of the Connections program on return‐to‐custody, mortality and treatment uptake among people with a history of opioid use: Retrospective cohort study in an Australian prison system', Addiction, vol. 119, no. 1, pp. 169-179.
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AbstractBackground and AimsConnections is a voluntary health program that facilitates access to opioid agonist treatment (OAT) and social services for people with opioid use exiting prison. This study aimed to measure the effectiveness of Connections in reducing recidivism and improving health outcomes for people with a history of opioid use on leaving prison.DesignRetrospective cohort study with quasi‐random allocation to the program.SettingPublic adult prisons in New South Wales, Australia, 2008–2015.ParticipantsAdults released from custody with a history of opioid use. Of 5549 eligible releasees, 3973 were allocated to Connections and 1576 to treatment‐as‐usual.MeasurementsOutcomes were return‐to‐custody, all‐cause mortality, and OAT participation.FindingsRegression analyses on an intention‐to‐treat basis, and adjusting for baseline propensity scores, comparing patients allocated to Connections versus treatment‐as‐usual showed no difference in rates of return‐to‐custody within 2 years (hazard ratio [HR]: 1.01; 95% confidence interval [CI]: 0.92 –1.12). Patients allocated to the Connections program were more likely to access OAT (odds ratio [OR]: 1.21; 95% CI: 1.06–1.39) and had lower mortality within 28 days of release (0.25% vs. 0.66%; HR: 0.38; 95% CI: 0.14–1.03). Differences in mortality did not persist beyond 28 days. Subgroup analyses showed that allocation to Connections was associated with higher risk of return‐to‐custody within 28 days for Aboriginal and/or Torres Strait Islander (Indigenous) and female releasees.Conclusions<...

Summers, BS, Thomas Broome, S, Pang, TWR, Mundell, HD, Koh Belic, N, Tom, NC, Ng, ML, Yap, M, Sen, MK, Sedaghat, S, Weible, MW, Castorina, A, Lim, CK, Lovelace, MD & Brew, BJ 2024, 'A Review of the Evidence for Tryptophan and the Kynurenine Pathway as a Regulator of Stem Cell Niches in Health and Disease', International Journal of Tryptophan Research, vol. 17.
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Stem cells are ubiquitously found in various tissues and organs in the body, and underpin the body’s ability to repair itself following injury or disease initiation, though repair can sometimes be compromised. Understanding how stem cells are produced, and functional signaling systems between different niches is critical to understanding the potential use of stem cells in regenerative medicine. In this context, this review considers kynurenine pathway (KP) metabolism in multipotent adult progenitor cells, embryonic, haematopoietic, neural, cancer, cardiac and induced pluripotent stem cells, endothelial progenitor cells, and mesenchymal stromal cells. The KP is the major enzymatic pathway for sequentially catabolising the essential amino acid tryptophan (TRP), resulting in key metabolites including kynurenine, kynurenic acid, and quinolinic acid (QUIN). QUIN metabolism transitions into the adjoining de novo pathway for nicotinamide adenine dinucleotide (NAD) production, a critical cofactor in many fundamental cellular biochemical pathways. How stem cells uptake and utilise TRP varies between different species and stem cell types, because of their expression of transporters and responses to inflammatory cytokines. Several KP metabolites are physiologically active, with either beneficial or detrimental outcomes, and evidence of this is presented relating to several stem cell types, which is important as they may exert a significant impact on surrounding differentiated cells, particularly if they metabolise or secrete metabolites differently. Interferon-gamma (IFN-γ) in mesenchymal stromal cells, for instance, highly upregulates rate-limiting enzyme indoleamine-2,3-dioxygenase (IDO-1), initiating TRP depletion and production of metabolites including kynurenine/kynurenic acid, known agonists of the Aryl hydrocarbon receptor (AhR) transcription factor. AhR transcriptionally regulates an immunosuppressive phenotype, making them attractive for regenera...

Thapa, R, Moglad, E, Afzal, M, Gupta, G, Bhat, AA, almalki, WH, Kazmi, I, Alzarea, SI, Pant, K, Ali, H, Paudel, KR, Dureja, H, Singh, TG, Singh, SK & Dua, K 2024, 'ncRNAs and their impact on dopaminergic neurons: Autophagy pathways in Parkinson's disease', Ageing Research Reviews, vol. 98, pp. 102327-102327.
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Thurn, B, Schotsmans, EMJ & Ueland, M 2024, 'Lime and odour: A preliminary investigation into the effect of hydrated lime on the volatiles emitted from human remains', Forensic Science International, vol. 358, pp. 111745-111745.
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Tobin, LA, Jarocki, VM, Kenyon, J, Drigo, B, Donner, E, Djordjevic, SP & Hamidian, M 2024, 'Genomic analysis of diverse environmental Acinetobacter isolates identifies plasmids, antibiotic resistance genes, and capsular polysaccharides shared with clinical strains', Applied and Environmental Microbiology, vol. 90, no. 2.
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ABSTRACT Acinetobacter baumannii, an important pathogen known for its widespread antibiotic resistance, has been the focus of extensive research within its genus, primarily involving clinical isolates. Consequently, data on environmental A. baumannii and other Acinetobacter species remain limited. Here, we utilized Illumina and Nanopore sequencing to analyze the genomes of 10 Acinetobacter isolates representing 6 different species sourced from aquatic environments in South Australia. All 10 isolates were phylogenetically distinct compared to clinical and other non-clinical Acinetobacter strains, often tens of thousands of single-nucleotide polymorphisms from their nearest neighbors. Despite the genetic divergence, we identified p dif modules (sections of mobilized DNA) carrying clinically important antimicrobial resistance genes in species other than A. baumannii , including carbapenemase oxa58, tetracycline resistance gene tet(39 ), and macrolide resistance genes msr(E)-mph(E ). These p dif modules were located on plasmids with high sequence identity to those circulating in globally distributed A. baumannii ST1 and ST2 clones. The environmental A. baumannii is...

Ueland, M, Bae, H, Udomkijmongkol, A, Kotmool, K, Gulati, V & Hussain, T 2024, 'Single atom dispersed tungsten disulfide (WS2) based nanosensors for VOCs detection related to decomposed humans in disaster events', FlatChem, vol. 45, pp. 100666-100666.
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van den Berge, M & Faiz, A 2024, 'Blood Biomarkers of Emphysema: What Can They Really Tell Us?', American Journal of Respiratory and Critical Care Medicine, vol. 209, no. 3, pp. 235-237.
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Van Haeften, S, Campbell, BC, Milic, A, Addison-Smith, E, Al Kouba, J, Huete, A, Beggs, PJ & Davies, JM 2024, 'Environmental DNA analysis of airborne poaceae (grass) pollen reveals taxonomic diversity across seasons and climate zones', Environmental Research, vol. 247, pp. 117983-117983.
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Vettori, L, Tran, HA, Mahmodi, H, Filipe, EC, Wyllie, K, Liu Chung Ming, C, Cox, TR, Tipper, J, Kabakova, IV, Rnjak-Kovacina, J & Gentile, C 2024, 'Silk fibroin increases the elasticity of alginate-gelatin hydrogels and regulates cardiac cell contractile function in cardiac bioinks', Biofabrication, vol. 16, no. 3, pp. 035025-035025.
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Abstract Silk fibroin (SF) is a natural protein extracted from Bombyx mori silkworm thread. From its common use in the textile industry, it emerged as a biomaterial with promising biochemical and mechanical properties for applications in the field of tissue engineering and regenerative medicine. In this study, we evaluate for the first time the effects of SF on cardiac bioink formulations containing cardiac spheroids (CSs). First, we evaluate if the SF addition plays a role in the structural and elastic properties of hydrogels containing alginate (Alg) and gelatin (Gel). Then, we test the printability and durability of bioprinted SF-containing hydrogels. Finally, we evaluate whether the addition of SF controls cell viability and function of CSs in Alg–Gel hydrogels. Our findings show that the addition of 1% (w/v) SF to Alg–Gel hydrogels makes them more elastic without affecting cell viability. However, fractional shortening (FS%) of CSs in SF–Alg–Gel hydrogels increases without affecting their contraction frequency, suggesting an improvement in contractile function in the 3D cultures. Altogether, our findings support a promising pathway to bioengineer bioinks containing SF for cardiac applications, with the ability to control mechanical and cellular features in cardiac bioinks.

Vo, PHN, Danaee, S, Hai, HTN, Huy, LN, Nguyen, TAH, Nguyen, HTM, Kuzhiumparambil, U, Kim, M, Nghiem, LD & Ralph, PJ 2024, 'Biomining for sustainable recovery of rare earth elements from mining waste: A comprehensive review', Science of The Total Environment, vol. 908, pp. 168210-168210.
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Vo, PHN, Ky Le, G, Huy, LN, Zheng, L, Chaiwong, C, Nguyen, NN, Nguyen, HTM, Ralph, PJ, Kuzhiumparambil, U, Danaee, S, Toft, S, Madsen, C, Kim, M, Fenstermacher, J, Hai, HTN, Duan, H & Tscharke, B 2024, 'Occurrence, spatiotemporal trends, fate, and treatment technologies for microplastics and organic contaminants in biosolids: A review', Journal of Hazardous Materials, vol. 466, pp. 133471-133471.
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Vo, PHN, Nguyen, TTP, Nguyen, HTM, Baulch, J, Dong, S, Nguyen, CV, Thai, PK & Nguyen, AV 2024, 'PFAS removal from landfill leachate by ozone foam fractionation: System optimization and adsorption quantification', Water Research, vol. 253, pp. 121300-121300.
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Vollset, SE, Ababneh, HS, Abate, YH, Abbafati, C, Abbasgholizadeh, R, Abbasian, M, Abbastabar, H, Abd Al Magied, AHA, Abd ElHafeez, S, Abdelkader, A, Abdelmasseh, M, Abd-Elsalam, S, Abdi, P, Abdollahi, M, Abdoun, M, Abdullahi, A, Abebe, M, Abiodun, O, Aboagye, RG, Abolhassani, H, Abouzid, M, Aboye, GB, Abreu, LG, Absalan, A, Abualruz, H, Abubakar, B, Abukhadijah, HJJ, Addolorato, G, Adekanmbi, V, Adetunji, CO, Adetunji, JB, Adeyeoluwa, TE, Adha, R, Adhikary, RK, Adnani, QES, Adzigbli, LA, Afrashteh, F, Afzal, MS, Afzal, S, Agbozo, F, Agodi, A, Agrawal, A, Agyemang-Duah, W, Ahinkorah, BO, Ahlstrom, AJ, Ahmad, A, Ahmad, F, Ahmad, MM, Ahmad, S, Ahmad, S, Ahmed, A, Ahmed, A, Ahmed, H, Ahmed, S, Ahmed, SA, Akinosoglou, K, Akkaif, MA, Akrami, AE, Akter, E, Al Awaidy, S, Al Hasan, SM, Al Mosa, AS, Al Ta'ani, O, Al Zaabi, OAM, Alahdab, F, Alajlani, MM, Al-Ajlouni, Y, Alalalmeh, SO, Al-Aly, Z, Alam, K, Alam, N, Alam, T, Alam, Z, Al-amer, RM, Alanezi, FM, Alanzi, TM, Albakri, A, Aldhaleei, WA, Aldridge, RW, Alemohammad, SY, Alemu, YM, Al-Gheethi, AAS, Al-Hanawi, MK, Ali, A, Ali, A, Ali, I, Ali, MU, Ali, R, Ali, SSS, Ali, VE, Ali, W, Al-Ibraheem, A, Alicandro, G, Alif, SM, Aljunid, SM, Alla, F, Almazan, JU, Al-Mekhlafi, HM, Alqutaibi, AY, Alrawashdeh, A, Alrousan, SM, Al-Sabah, SK, Alsabri, MA, Altaany, Z, Al-Tammemi, AB, Al-Tawfiq, JA, Altirkawi, KA, Aluh, DO, Alvis-Guzman, N, Al-Wardat, MS, Al-Worafi, YM, Aly, H, Alyahya, MS, Alzoubi, KH, Al-Zyoud, W, Amani, R, Ameyaw, EK, Amin, TT, Amindarolzarbi, A, Amiri, S, Amirzade-Iranaq, MH, Amu, H, Amugsi, DA, Ancuceanu, R, Anderlini, D, Anderson, DB, Andrade, PP, Andrei, CL, Andrei, T, Andrews, EA, Anil, A, Anil, S, Anoushiravani, A, Antony, CM, Antriyandarti, E, Anuoluwa, BS, Anvari, S, Anyasodor, AE, Appiah, F, Aquilano, M, Arab, JP, Arabloo, J, Arafa, EA, Arafat, M, Aravkin, AY, Ardekani, A, Areda, D, Aregawi, BB, Aremu, A, Ariffin, H, Arkew, M, Armani, K, Artamonov, AA, Arumugam, A, Asghari-Jafarabadi, M, Ashbaugh, C, Astell-Burt, T, Athari, SS, Atorkey, P, Atout, MMW, Aujayeb, A, Ausloos, M, Awad, H, Awotidebe, AW, Ayatollahi, H, Ayuso-Mateos, JL, Azadnajafabad, S, Azeez, FK, Azevedo, RMS, Badar, M, Baghdadi, S, Bagheri, M, Bagheri, N, Bai, R, Baker, JL, Bako, AT, Balakrishnan, S, Balcha, WF, Baltatu, OC, Barchitta, M, Bardideh, E, Barker-Collo, SL, Bärnighausen, TW, Barqawi, HJ & et al. 2024, 'Burden of disease scenarios for 204 countries and territories, 2022–2050: a forecasting analysis for the Global Burden of Disease Study 2021', The Lancet, vol. 403, no. 10440, pp. 2204-2256.
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Wajahat, M, Kouzani, AZ, Khoo, SY & Mahmud, MAP 2024, 'Development of Triboelectric Nanogenerators Using Novel 3D Printed Polymer Materials', Advanced Engineering Materials, vol. 26, no. 3.
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Triboelectric nanogenerators (TENGs) are becoming attractive devices for harvesting mechanical energy. 3D printing (3DP) is a newly reported technique for the development of this device. This technique is not fully explored for the fabrication of triboelectric materials and compatible printing processes. Herein, three main 3DP techniques including powder‐based multijet fusion, resin‐based polyjet fusion, and filament‐based fused deposition modeling are utilized to investigate new sets of 3DP triboelectric materials. Mechanical to electrical conversion efficiency of 3D printed and commercially available negative and positive triboelectric materials are compared and investigated. Polyamide ‐12 (PA12), Veroclear, acrylonitrile‐styrene‐acrylate (ASA), copper‐coated polylactic acid (Cu‐PLA), polycarbonate (PC), and polyethylene terephthalate glycol (PETG) are fabricated using compatible 3D printing techniques. 3D‐printed PA12 is considered as a reference positive triboelectric layer. Meanwhile, 3D‐printed Veroclear, ASA, Cu‐PLA, PC, PETG, and commercial materials like Teflon sheets, PA6,6 conductive sheets, indium tin oxide‐coated polyethylene terephthalate, conductive‐nylon sheets, and PVDF membrane are selected as negative triboelectric materials. The maximum AC voltage of 80 V and maximum instantaneous current of 0.9 μA are produced by pairing 3DP‐PA12 and 3DP‐Veroclear under open circuit condition. This AC output is further converted to DC output using brdige rectifier circuitry to efficiently charge up the capacitor and glow series of 16 LEDs.

Wang, Q, Zhang, Y, Li, H, Ying, S, Ding, Z, Wang, Y, Fang, T, Wei, C, Ma, C, Sun, B, Liu, X & Tang, X 2024, 'Unlocking the potential of ionic liquid-functionalized aqueous electrolytes for aqueous ammonium-bromine/ion batteries', Energy Storage Materials, vol. 70, pp. 103553-103553.
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Wang, Y, Thaler, M, Salgado‐Benvindo, C, Ly, N, Leijs, AA, Ninaber, DK, Hansbro, PM, Boedijono, F, van Hemert, MJ, Hiemstra, PS, van der Does, AM & Faiz, A 2024, 'SARS‐CoV‐2‐infected human airway epithelial cell cultures uniquely lack interferon and immediate early gene responses caused by other coronaviruses', Clinical & Translational Immunology, vol. 13, no. 4.
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AbstractObjectivesSevere acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) is a member of a class of highly pathogenic coronaviruses. The large family of coronaviruses, however, also includes members that cause only mild symptoms, like human coronavirus‐229E (HCoV‐229E) or OC43 (HCoV‐OC43). Unravelling how molecular (and cellular) pathophysiology differs between highly and low pathogenic coronaviruses is important for the development of therapeutic strategies.MethodsHere, we analysed the transcriptome of primary human bronchial epithelial cells (PBEC), differentiated at the air–liquid interface (ALI) after infection with SARS‐CoV‐2, SARS‐CoV, Middle East Respiratory Syndrome (MERS)‐CoV and HCoV‐229E using bulk RNA sequencing.ResultsALI‐PBEC were efficiently infected by all viruses, and SARS‐CoV, MERS‐CoV and HCoV‐229E infection resulted in a largely similar transcriptional response. The response to SARS‐CoV‐2 infection differed markedly as it uniquely lacked the increase in expression of immediate early genes, including FOS, FOSB and NR4A1 that was observed with all other coronaviruses. This finding was further confirmed in publicly available experimental and clinical datasets. Interfering with NR4A1 signalling in Calu‐3 lung epithelial cells resulted in a 100‐fold reduction in extracellular RNA copies of SARS‐CoV‐2 and MERS‐CoV, suggesting an involvement in virus replication. Furthermore, a lack in induction of interferon‐related gene expression characterised the main difference between the highly pathogenic coronaviruses and low pathogenic viruses HCoV‐229E and HCoV‐OC43.ConclusionOur results demonstrate a previousl...

Wang, Y, Weng, S, Tang, Y, Lin, S, Liu, X, Zhang, W, Liu, G, Pandi, B, Wu, Y, Ma, L & Wang, L 2024, 'A transmembrane scaffold from CD20 helps recombinant expression of a chimeric claudin 18.2 in an in vitro coupled transcription and translation system', Protein Expression and Purification, vol. 215, pp. 106392-106392.
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Wang, Y, Yang, X, Meng, Y, Wen, Z, Han, R, Hu, X, Sun, B, Kang, F, Li, B, Zhou, D, Wang, C & Wang, G 2024, 'Fluorine Chemistry in Rechargeable Batteries: Challenges, Progress, and Perspectives', Chemical Reviews, vol. 124, no. 6, pp. 3494-3589.
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Ward, J 2024, 'The operationalization of a multifaceted, multijurisdictional, multiagency and multidisciplinary capability for unidentified and missing persons investigations in Australia', Australian Journal of Forensic Sciences, vol. 56, no. sup1, pp. 65-70.
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Ward, J, Coakley, L, Grisedale, K, Seddon, S, Spiden, M, Watson, JL & McNevin, D 2024, 'Operationalization of the National DNA Program for Unidentified and Missing Persons' Forensic Investigative Genetic Genealogy Capability for Human Remains Identification in Australia', Forensic Genomics, vol. 4, no. 1, pp. 32-40.
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Waszczuk, JR, Peacock, L, Chadwick, S, Maynard, P, Raymond, J & Roux, C 2024, 'Misidentifications of alphanumeric characters in serial number restorations', Australian Journal of Forensic Sciences, vol. 56, no. 2, pp. 168-188.
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Chemical etching has long been established as a reliable means of recovering defaced characters such as serial numbers. Although successful restorations can present clearly defined characters, a preliminary assessment of proficiency test results shows varied participant interpretations of samples marked with the same characters. Thus, a study was completed to determine if specific alphanumeric characters are more likely to be misidentified, comprising a practical exercise and analysis of 16 compiled proficiency test results. The practical exercise involved 64 steel plates stamped with six randomized characters that were removed and chemically restored. Participants individually assessed the plates and provided their interpretations. A total of 39 participants of various backgrounds and experience in serial number restorations were used in this study. After comparing participant interpretations with the ground truth, characters more prone to be misidentified were determined. The proficiency test results showed that the most frequently misidentified characters were the letters B and N, among a limited set. Whilst the practical assessment found a notable increase in misidentifications for the letters G, Q and S. Interestingly, none of these characters were used in the proficiency tests. It is hoped that the results of this study raise awareness for forensic examiners undertaking restorations.

Watson, J, McNevin, D, Grisedale, K, Spiden, M, Seddon, S & Ward, J 2024, 'Operationalisation of the ForenSeq® Kintelligence Kit for Australian unidentified and missing persons casework', Forensic Science International: Genetics, vol. 68, pp. 102972-102972.
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Single nucleotide polymorphism (SNP) genotyping technologies can generate investigative leads for human remains identification, including estimation of biological sex, biogeographical ancestry (BGA), externally visible characteristics (EVCs), identity, uniparental lineage and extended kinship. The ForenSeq® Kintelligence Kit provides forensic laboratories with the ability to apply this suite of genetic tools to forensic samples using one panel targeting 10,230 SNPs (including 56 ancestry-informative, 24 phenotype-informative, 94 identity-informative, 106 X chromosome, 85 Y chromosome and 9867 kinship-informative SNPs) sequenced on the MiSeq FGx® Sequencing System. The ForenSeq® Kintelligence Kit has been internally validated, optimised and operationalised by the Australian Federal Police National DNA Program for Unidentified and Missing Persons (AFP Program) for coronial casework. The internal validation was conducted according to the Scientific Working Group on DNA Analysis Methods guidelines (excluding mixture analysis), focussing on sample types typically encountered in human remains identification casework, such as bones, teeth, nail, blood and hair. The workflow was optimised for a high throughput library preparation and sequencing workflow, and additional analytical thresholds were developed to improve genotyping accuracy for low DNA input samples. Additionally, the genetic intelligence generated from the kit was compared to the self-declared biological sex, EVCs and BGA of the DNA donors to assess concordance. The kit was able to produce high quality SNP profiles from 1.0 ng down to 0.1 ng of DNA, with high repeatability and reproducibility, and minimal background noise. The prediction accuracy for biological sex (95%), hair colour (58%), eye colour (74%) and BGA inferences (consistent: 74%; partially consistent: 10%; inconclusive: 16%) was determined based on self-declared data. Additionally, SNP profiles from a volunteer family group of ten rel...

Watson, JL, McNevin, D & Ward, J 2024, 'Genetic Kinship Testing Techniques for Human Remains Identification and Missing Persons Investigations', Forensic Genomics, vol. 4, no. 1, pp. 4-23.
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Weyermann, C, Willis, S, Margot, P & Roux, C 2024, 'Response to the letter to the Editor commenting on “Towards more relevance in forensic science research and development” by Weyermann et al.', Forensic Science International, vol. 355, pp. 111928-111928.
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Windhagauer, M, Doblin, MA, Signal, B, Kuzhiumparambil, U, Fabris, M & Abbriano, RM 2024, 'Metabolic response to a heterologous poly-3-hydroxybutyrate (PHB) pathway in Phaeodactylum tricornutum', Applied Microbiology and Biotechnology, vol. 108, no. 1, pp. 1-16.
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Wong‐Bajracharya, J, Webster, J, Rigano, LA, Kant, P, Englezou, A, Snijders, F, Roach, R, Wang, C, Kehoe, M, Mann, R, Constable, FE & Chapman, TA 2024, 'All‐in‐one Xylella detection and identification: A nanopore sequencing‐compatible conventional PCR', Plant Pathology, vol. 73, no. 5, pp. 1072-1089.
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AbstractXylella fastidiosa is a plant‐pathogenic bacterium that poses a serious threat to the production of economically important plant species including grapes, almonds, olives and a broad range of amenity plants, causing significant economic losses worldwide. While multiple molecular detection assays have been developed for X. fastidiosa, there is a lack of molecular tools available for detection and differentiation of the closely related pear pathogen, Xylella taiwanensis. In this study, we present a novel conventional PCR assay with primers that can amplify both Xylella species. The amplified product could be sequenced and used for discrimination between the two species and the subspecies within the fastidiosa species. This PCR assay was designed using a genome‐informed approach to target the ComEC/Rec2 gene of both Xylella species, ensuring a higher specificity than other previously developed PCR assays. A test performance study across five national plant diagnostic laboratories in Australia and New Zealand demonstrated this assay's high sensitivity and specificity to all known species and subspecies within the Xylella genus. This PCR assay can be used for Xylella identification at the species and subspecies level and is compatible with Sanger sequencing and nanopore sequencing for rapid turnaround time. The newly developed conventional PCR assay presented here offers rapid detection and accurate identification of both Xylella species from plant, insect vector or bacterial samples, enabling timely implementation of biosecurity measures or disease management responses.

Wright, K, Han, DJY, Song, R, de Silva, K, Plain, KM, Purdie, AC, Shepherd, A, Chin, M, Hortle, E, Wong, JJ-L, Britton, WJ & Oehlers, SH 2024, 'Zebrafishtsc1andcxcl12aincrease susceptibility to mycobacterial infection', Life Science Alliance, vol. 7, no. 4, pp. e202302523-e202302523.
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Regulation of host miRNA expression is a contested node that controls the host immune response to mycobacterial infection. The host must counter subversive efforts of pathogenic mycobacteria to launch a protective immune response. Here, we examine the role of miR-126 in the zebrafish–Mycobacterium marinuminfection model and identify a protective role for infection-induced miR-126 through multiple effector pathways. We identified a putative link between miR-126 and thetsc1aandcxcl12a/ccl2/ccr2signalling axes resulting in the suppression of non-tnfaexpressing macrophage accumulation at earlyM. marinumgranulomas. Mechanistically, we found a detrimental effect oftsc1aexpression that renders zebrafish embryos susceptible to higher bacterial burden and increased cell death via mTOR inhibition. We found that macrophage recruitment driven by thecxcl12a/ccl2/ccr2signalling axis was at the expense of the recruitment of classically activatedtnfa-expressing macrophages and increased cell death around granulomas. Together, our results delineate putative pathways by which infection-induced miR-126 may shape an effective immune response toM. marinuminfection in zebrafish embryos.

Wyrsch, ER, Hoye, BJ, Sanderson-Smith, M, Gorman, J, Maute, K, Cummins, ML, Jarocki, VM, Marenda, MS, Dolejska, M & Djordjevic, SP 2024, 'The faecal microbiome of the Australian silver gull contains phylogenetically diverse ExPEC, aEPEC and Escherichia coli carrying the transmissible locus of stress tolerance', Science of The Total Environment, vol. 919, pp. 170815-170815.
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Xiang, M, Jiang, Y, Zhou, J, Bao, G, Luo, X, Zhang, L, Jin, D, Xian, Y & Zhang, C 2024, 'NIR light-controlled DNA nanodevice for amplified mRNA imaging and precise gene therapy', Nano Today, vol. 54, pp. 102110-102110.
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Xiao, J, Xiao, Y, Wang, S, Huang, Z, Li, J, Gong, C, Zhang, G, Sun, B, Gao, H, Li, H, Guo, X, Wang, Y, Liu, H & Wang, G 2024, 'Surface engineering of P2-type cathode material targeting long-cycling and high-rate sodium-ion batteries', Journal of Energy Chemistry.
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Xu, J, Li, H, Jin, Y, Zhou, D, Sun, B, Armand, M & Wang, G 2024, 'Understanding the Electrical Mechanisms in Aqueous Zinc Metal Batteries: From Electrostatic Interactions to Electric Field Regulation', Advanced Materials, vol. 36, no. 3, p. e2309726.
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AbstractAqueous Zn metal batteries are considered as competitive candidates for next‐generation energy storage systems due to their excellent safety, low cost, and environmental friendliness. However, the inevitable dendrite growth, severe hydrogen evolution, surface passivation, and sluggish reaction kinetics of Zn metal anodes hinder the practical application of Zn metal batteries. Detailed summaries and prospects have been reported focusing on the research progress and challenges of Zn metal anodes, including electrolyte engineering, electrode structure design, and surface modification. However, the essential electrical mechanisms that significantly influence Zn2+ ions migration and deposition behaviors have not been reviewed yet. Herein, in this review, the regulation mechanisms of electrical‐related electrostatic repulsive/attractive interactions on Zn2+ ions migration, desolvation, and deposition behaviors are systematically discussed. Meanwhile, electric field regulation strategies to promote the Zn2+ ions diffusion and uniform Zn deposition are comprehensively reviewed, including enhancing and homogenizing electric field intensity inside the batteries and adding external magnetic/pressure/thermal field to couple with the electric field. Finally, future perspectives on the research directions of the electrical‐related strategies for building better Zn metal batteries in practical applications are offered.

Xu, J, Qiu, Y, Yang, J, Li, H, Han, P, Jin, Y, Liu, H, Sun, B & Wang, G 2024, 'Review of Separator Modification Strategies: Targeting Undesired Anion Transport in Room Temperature Sodium–Sulfur/Selenium/Iodine Batteries', Advanced Functional Materials, vol. 34, no. 2.
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AbstractRechargeable sodium–sulfur/selenium/iodine (Na–S/Se/I2) batteries are regarded as promising candidates for large‐scale energy storage systems, with the advantages of high energy density, low cost, and environmental friendliness. However, the electrochemical performances of Na–S/Se/I2 batteries are still restricted by several inherent issues, including the “shuttle effect” of polysulfides/polyselenides/polyiodides (PSs/PSes/PIs), sluggish kinetics of the conversion reactions at the cathodes, and Na dendrite growth at the anodes. Among these challenges, uncontrolled “shuttle effect” of PSs/PSes/PIs is a major contributing factor for the irreversible loss of active cathode materials and severe side reactions on Na metal anodes, leading to rapid failure of the batteries. Separator modification has been demonstrated to be an effective strategy to suppress the shuttling of PSs/PSes/PIs. Herein, the latest achievement in modifying separators for high‐performance Na–S/Se/I2 batteries is comprehensively reviewed. The reaction mechanisms of each battery system are first discussed. Then, strategies of separator modification based on the different functions for regulating the transportation of PSs/PSes/PIs are summarized, including applying electrostatic repulsive interaction, introducing conductive layers, improving sieving effects, enhancing chemisorption capability, and adding efficient electrocatalysts. Finally, future perspectives on the practical application of modified separators in high‐energy rechargeable batteries are provided.

Xu, J, Yang, J, Qiu, Y, Jin, Y, Wang, T, Sun, B & Wang, G 2024, 'Achieving high-performance sodium metal anodes: From structural design to reaction kinetic improvement', Nano Research, vol. 17, no. 3, pp. 1288-1312.
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AbstractSodium metal is one of the ideal anodes for high-performance rechargeable batteries because of its high specific capacity (~ 1166 mAh·g−1), low reduction potential (−2.71 V compared to standard hydrogen electrodes), and low cost. However, the unstable solid electrolyte interphase, uncontrolled dendrite growth, and inevitable volume expansion hinder the practical application of sodium metal anodes. At present, many strategies have been developed to achieve stable sodium metal anodes. Here, we systematically summarize the latest strategies adopted in interface engineering, current collector design, and the emerging methods to improve the reaction kinetics of sodium deposition processes. First, the strategies of constructing protective layers are reviewed, including inorganic, organic, and mixed protective layers through electrolyte additives or pretreatments. Then, the classification of metal-based, carbon-based, and composite porous frames is discussed, including their function in reducing local deposition current density and the effect of introducing sodiophilic sites. Third, the recent progress of alloys, nanoparticles, and single atoms in improving Na deposition kinetics is systematically reviewed. Finally, the future research direction and the prospect of high-performance sodium metal batteries are proposed.

Xu, X, Wang, W, Qiao, L, Fu, Y, Ge, X, Zhao, K, Zhanghao, K, Guan, M, Chen, X, Li, M, Jin, D & Xi, P 2024, 'Ultra-high spatio-temporal resolution imaging with parallel acquisition-readout structured illumination microscopy (PAR-SIM)', Light: Science & Applications, vol. 13, no. 1, p. 125.
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AbstractStructured illumination microscopy (SIM) has emerged as a promising super-resolution fluorescence imaging technique, offering diverse configurations and computational strategies to mitigate phototoxicity during real-time imaging of biological specimens. Traditional efforts to enhance system frame rates have concentrated on processing algorithms, like rolling reconstruction or reduced frame reconstruction, or on investments in costly sCMOS cameras with accelerated row readout rates. In this article, we introduce an approach to elevate SIM frame rates and region of interest (ROI) coverage at the hardware level, without necessitating an upsurge in camera expenses or intricate algorithms. Here, parallel acquisition-readout SIM (PAR-SIM) achieves the highest imaging speed for fluorescence imaging at currently available detector sensitivity. By using the full frame-width of the detector through synchronizing the pattern generation and image exposure-readout process, we have achieved a fundamentally stupendous information spatial-temporal flux of 132.9 MPixels · s−1, 9.6-fold that of the latest techniques, with the lowest SNR of −2.11 dB and 100 nm resolution. PAR-SIM demonstrates its proficiency in successfully reconstructing diverse cellular organelles in dual excitations, even under conditions of low signal due to ultra-short exposure times. Notably, mitochondrial dynamic tubulation and ongoing membrane fusion processes have been captured in live COS-7 cell, recorded with PAR-SIM at an impressive 408 Hz. We posit that this novel parallel exposure-readout mode not only augments SIM pattern modulation for superior frame rates but also holds the potential to benefit other complex imaging systems with a strategic controlling approach.

Yeung, S, Paudel, KR, Rubis, GD, Williams, KA, Hansbro, PM & Dua, K 2024, 'Exploring the current advancements of quercetin nanoformulations alleviating respiratory diseases', Future Medicinal Chemistry, vol. 16, no. 10, pp. 925-928.
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Yin, M, Wadhwa, R, Marshall, JE, Gillis, CM, Kim, RY, Dua, K, Palsson-McDermott, EM, Fallon, PG, Hansbro, PM & O’Neill, LAJ 2024, '4-Octyl Itaconate Alleviates Airway Eosinophilic Inflammation by Suppressing Chemokines and Eosinophil Development', The Journal of Immunology, vol. 212, no. 1, pp. 13-23.
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Abstract 4-Octyl itaconate (4-OI) is a derivative of the Krebs cycle–derived metabolite itaconate and displays an array of antimicrobial and anti-inflammatory properties through modifying cysteine residues within protein targets. We have found that 4-OI significantly reduces the production of eosinophil-targeted chemokines in a variety of cell types, including M1 and M2 macrophages, Th2 cells, and A549 respiratory epithelial cells. Notably, the suppression of these chemokines in M1 macrophages was found to be NRF2-dependent. In addition, 4-OI can interfere with IL-5 signaling and directly affect eosinophil differentiation. In a model of eosinophilic airway inflammation in BALB/c mice, 4-OI alleviated airway resistance and reduced eosinophil recruitment to the lungs. Our findings suggest that itaconate derivatives could be promising therapeutic agents for the treatment of eosinophilic asthma.

Yuen, ZW-S, Shanmuganandam, S, Stanley, M, Jiang, S, Hein, N, Daniel, R, McNevin, D, Jack, C & Eyras, E 2024, 'Profiling age and body fluid DNA methylation markers using nanopore adaptive sampling', Forensic Science International: Genetics, vol. 71, pp. 103048-103048.
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Zhang, L, Jiang, M, Tian, H, Liu, S, Zhou, X, Liu, H, Gan, S, Che, S, Chen, Z, Li, Y, Wang, T, Wang, G & Wang, C 2024, 'Oxygen and Nitrogen Vacancies in a BiOBr/g-C₃N₄ Heterojunction for Sustainable Solar Ammonia Fertilizer Synthesis', ACS Sustainable Chemistry & Engineering, vol. 12, no. 5, pp. 2028-2040.
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Zhang, Q, Lai, N, He, M, Yang, Y, Huang, Q, Quan, Y, Hou, S, Gao, X, Song, Y, Liao, J & Wang, R 2024, 'Tunable broadband luminescence of Bi‐ion‐doped glasses via Gd₂O₃ co‐doping', Journal of the American Ceramic Society, vol. 107, no. 6, pp. 3837-3844.
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AbstractThe doping of bismuth (Bi) ions in borosilicate glasses has gained attention for its potential applications in LED light sources and imaging displays. Here, gadolinium oxide (Gd2O3) was introduced into the glass matrix in varying concentrations using a high‐temperature melting method to investigate its impact on the luminescence properties of Bi ions. The resulting glass exhibited bimodal emission peaks at 465 and 750 nm when excited with 325 nm light. The luminescence intensity and fluorescence half width at half height initially increased, followed by a subsequent decrease as the Gd2O3 content in the glass increased from 10 to 43 mol%. Additionally, the color of the luminescence transformed from purple–red to green under white light irradiation. The composition and excitation wavelength of the glass can be adjusted to achieve selective tuning of the luminescence.

Zhao, F, Guan, Y, Su, F, Du, Z, Wen, S, Zhang, L & Jin, D 2024, 'Lanthanide-Complex-Enhanced Bioorthogonal Branched DNA Amplification', Analytical Chemistry, vol. 96, no. 4, pp. 1556-1564.
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Zhao, S, Li, G, Zhang, B, Li, T, Luo, M, Sun, B, Wang, G & Guo, S 2024, 'Technological roadmap for potassium-ion hybrid capacitors', Joule, vol. 8, no. 4, pp. 922-943.
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Zheng, J, Xue, C, Wang, G, Mahmud, MA, Sun, Z, Liao, C, Yi, J, Qu, J, Yang, L, Wang, L, Bremner, S, Cairney, JM, Zhang, J & Ho-Baillie, AWY 2024, 'Efficient Flexible Monolithic Perovskite–CIGS Tandem Solar Cell on Conductive Steel Substrate', ACS Energy Letters, vol. 9, no. 4, pp. 1545-1547.
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Zhu, X, Ma, X, Zhang, Z, Liu, Y, Luo, Y, Yan, K, Pei, T & Huete, A 2024, 'Floating in the air: forecasting allergenic pollen concentration for managing urban public health', International Journal of Digital Earth, vol. 17, no. 1.
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Chen, H, Galvao, I, Donovan, C, Kim, RY, Ortega, DG, Idrees, S, Gillis, CM, Faiz, A & Hansbro, P 1970, 'Revealing Lung Periphery Alterations in COPD Via Spatial Transcriptomics', C19. CHARTING THE LUNG: INNOVATION IN MULTIOMICS, American Thoracic Society 2024 International Conference, May 17-22, 2024 - San Diego, CA, American Thoracic Society.
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Etminaniesfahani, A, Gu, H, Naeni, L & Salehipour, A 1970, 'An Efficient Approximate Dynamic Programming Approach for Resource-Constrained Project Scheduling with Uncertain Task Duration', Proceedings of the 13th International Conference on Operations Research and Enterprise Systems, 13th International Conference on Operations Research and Enterprise Systems, SCITEPRESS - Science and Technology Publications.
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Ajani, P, Dove, M, Farrell, H, O'Connor, W, Tesoriero, M, Verma, A, Zammit, A, Hughes, B, Parker, L & Murray, S University of Technology Sydney 2024, Transforming Australian Shellfish Production: Lower Limeburners Creek Harvest Area, Hastings River Report on Stage 1, May 2018 - March 2021, Sydney, Australia., Sydney.

Ajani, P, Vig, D, Dove, M, Farrell, H, O'Connor, W, Tesoriero, M, Verma, A, Zammit, A, Hughes, B, Parker, L & Murray, S UTS 2024, 2023 Transforming Australian Shellfish Production: Coba Bay Harvest Area, Hawkesbury River Report on Stage 1, May 2018 - March 2021, Sydney, Australia., Sydney Australia.

Bollati, E, Hughes, DJ, Suggett, DJ, Raina, J-B & Kühl, M 2024, 'Microscale sampling of the coral gastric cavity reveals a gut-like microbial community', Cold Spring Harbor Laboratory.
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Brown, HJ, Islam, MI, Ruan, J, Baker, MAB, Ithurbide, S & Duggin, IG 2024, 'CetZ1-dependent assembly and positioning of the motility machinery inhaloarchaea', Cold Spring Harbor Laboratory.
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Chen, Y-C, Fang, G, Qiao, Z, Zhu, H, Xie, J, Zhou, T, Xiong, Z & Jin, D 2024, 'Single-Cell Laser Emitting Cytometry for Label-Free Nucleolus Fingerprinting', Research Square Platform LLC.
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de Silva, RT, Shinde, V, Brown, HJ, Liao, Y & Duggin, IG 2024, 'Dynamic self-association of archaeal tubulin-like protein CetZ1 drivesHaloferax volcaniimorphogenesis', Cold Spring Harbor Laboratory.
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Elder, M, Piggott, A, Stober, F, Thumm, A & Weiß, A 2024, 'Finite groups with geodetic Cayley graphs'.

Ganesan, K, Ghorbanpour, S, Kendall, W, Broome, ST, Gladding, JM, Dhungana, A, Abiero, AR, Mahmoudi, M, Castorina, A, Kendig, MD, Becchi, S, Valova, V, Cole, L & Bradfield, LA 2024, 'Hippocampal neuroinflammation causes sex-specific disruptions in action selection, food approach memories, and neuronal excitation', Cold Spring Harbor Laboratory.
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Gaya, MS, Felgate, H, Siani, H, Whitchurch, CB & Webber, MA 2024, 'FakA impacts antiseptic susceptibility inStaphylococcus aureusandEnterococcus faecalis', Cold Spring Harbor Laboratory.
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Hasebe, K, Kendig, MD, Kaakoush, NO, Tajaddini, A, Westbrook, RF & Morris, MJ 2024, 'Impact of maternal obesogenic diet on maternal and offspring microbiome development', Cold Spring Harbor Laboratory.
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Horder, J, Scognamiglio, D, Ganyecz, Á, Ivády, V, Kianinia, M, Toth, M & Aharonovich, I 2024, 'Near-coherent quantum emitters in hexagonal boron nitride with discrete polarization axes'.

Ithurbide, S, de Silva, RT, Brown, HJ, Shinde, V & Duggin, IG 2024, 'A vector system for single and tandem expression of cloned genes and multi-colour fluorescent tagging inHaloferax volcanii', Cold Spring Harbor Laboratory.
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Liu, Y, Cao, Q, Xu, H & Lin, G 2024, 'Flow Tweezing of Anisotropic Magnetic Microrobots in a Dynamic Magnetic Trap for Active Retention and Localized Flow Sensing', Research Square Platform LLC.
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Liu, Y, Huete, A, Xie, Q, Davies, JM, Beggs, PJ, Abdollahi, A, Pradhan, B & Zhang, X 2024, 'Informing spatial distributions and temporal variations of grass pollen sources in urban landscapes using 10 m Sentinel-2 data', Research Square Platform LLC.
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Ma, Y, Dickson, KA, Field, N, Xie, T, Tran, N & Marsh, DJ 2024, 'Abstract A038: Epigenetic compound library screen of ovarian clear cell carcinoma cell line models identifies decreased cell viability following treatment with the Bruton tyrosine kinase inhibitor ibrutinib', American Association for Cancer Research (AACR), pp. A038-A038.
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Abstract Ovarian clear cell carcinoma (OCCC) is a difficult to treat histological subtype of ovarian cancer, demonstrating resistance to standard chemotherapy. New approaches are required in order to identify compounds with the potential to target this tumor. OCCC are characterized by mutations in ARID1A and/or ARID1B (AT-rich interactive domain-containing proteins) that encode for members of the mammalian SWI/SNF (SWItch/Sucrose Non-Fermentable) chromatin remodeling complex. We have used an epigenetic library consisting of 160 compounds that targets epigenetic readers, writers, erasers, and transcriptional modulators, to screen seven OCCC cell line models (RMG1, JHOC5, OVTOKO, OVMANA, OVISE, OV207 and TOV21G) and three non-OCCC ovarian cancer cell line models (A2780, COV434 and OVCAR8). Cell lines were seeded in triplicate into 96-well plates and treated with all 160 compounds at both 5 µM and 0.5 µM, as well as with a DMSO vehicle control, for 72 hours. Following treatment, cell viability was determined using a MTS assay and each data point normalized to the DMSO control. Based on the results of viability assays, drugs were sought that preferentially targeted OCCC relative to non-OCCC cell lines. Drugs that increased cell proliferation in two or more of the OCCC lines were removed from the analysis, as were drugs that did not impact upon viability. Drug 152, ibrutinib, inhibited cell viability between 53 to 78% in 6 of the 7 OCCC cell lines at 5 µM, with an average inhibition of 64%. In non-OCCC cell lines, the average cell viability after treatment with 5 µM ibrutinib was 91% (range, 84 – 103%). Ibrutinib is a small molecule inhibitor of Bruton tyrosine kinase (BTK) that has been approved by the FDA for treatment of a number of hematological malignancies including mantle cell lymphoma, small lymphocytic lymphoma and chronic lymphocytic leukemia. BTK functions in B-cell receptor signaling, regulating B c...

Mahmodi, H, Poulton, CG, Lesley, MN, Oldham, G, Ong, HX, Langford, SJ & Kabakova, IV 2024, 'Principal Component Analysis in Application to Brillouin Microscopy Data'.

Mor, S, Singh, V, Neira, V, Brito, BP, Ariyama, N & Sturos, M 2024, 'Genetic characterization of a novel bovine Rotavirus A G37P[52] closely related to human strains', Authorea, Inc..
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Morshed, N, Rennie, C, Faria, M, Collins-Praino, L & Care, A 2024, 'Protein Coronas Derived from Cerebrospinal Fluid Enhance the Interactions Between Nanoparticles and Brain Cells', Cold Spring Harbor Laboratory.
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Pearmain, L, Jokl, E, Simpson, K, Birchall, L, Ou, Y, Lawless, C, Simpson, A, Mann, L, Scott, N, Shah, R, Venkateswaran, R, Stanel, S, Hayton, C, Rivera-Ortega, P, Hansbro, P, Hanley, NA, Blaikley, JF & Hanley, KP 2024, 'SOX9-regulated matrix proteins predict poor outcomes in patients with COVID-19 and pulmonary fibrosis', Cold Spring Harbor Laboratory.
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Pokhrel, A, Costas, A, Pittorino, M, Duggin, I & Söderström, B 2024, 'E. colidivision machinery drives cocci development inside host cells', Cold Spring Harbor Laboratory.
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Rudolf, D, Smith, A & Quiroz, M 2024, 'Perturbations of Markov Chains'.

Ryder, WG, Graziotto, ME, Levina, A, Hawkins, B, Hibbs, DE, New, EJ & Gale, PA 2024, 'Subcellular targeted anion transporters', American Chemical Society (ACS).
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Salih, AK, Khan, AZ, Drmosh, QA, Kandiel, TA, Qamar, M, Jahangir, TN, Ton-That, C & Yamani, ZH 2024, 'Nanostructured BiVO4 Photoanodes Fabricated by Vanadium-infused Interaction for Efficient Solar Water Splitting'.

Suyama, H, Luu, LDW, Zhong, L, Raftery, MJ & Lan, R 2024, 'Proteomic comparison of epidemic AustralianBordetella pertussisbiofilm cells', Cold Spring Harbor Laboratory.
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Vyas, HKN, Hoque, MM, Xia, B, Alam, D, Cullen, PJ, Rice, SA & Mai-Prochnow, A 2024, 'Transcriptional Signatures Associated with the Survival ofEscherichia coliBiofilm During Treatment with Plasma-Activated Water', Cold Spring Harbor Laboratory.
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Webb, C 2024, 'If you win $150 million, odds are you’ll have big decisions to make. Here’s what to do', Sydney Morning Herald.