Alzahrani, SA, De Silva, KSB, Dowd, A, Arnold, MD & Cortie, MB 2024, 'Effect of precursor composition and heat-treatment on the morphology and physical properties of Ag nanosponges', Results in Surfaces and Interfaces, pp. 100217-100217.
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Angeloski, A, Flower‐Donaldson, K, Matar, F, Hayes, DC, Duman, MN, Oldfield, DT, Westerhausen, MT & McDonagh, AM 2024, 'Gold Microstructures by Thermolysis of Gold(III) Di‐isopropyldithiocarbamate Complexes', ChemNanoMat, vol. 10, no. 3.
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AbstractElemental gold was formed by thermolysis of gold(III) dithiocarbamate single‐source precursors, which exist as two complexes. The complexes were readily synthesised from the reaction between chloroauric acid and sodium di‐isopropyldithiocarbamate and could be isolated from each other. The thermal decomposition processes were evaluated using thermogravimetry and electrical resistance measurements. The structure and purity of the resultant gold was examined using scanning electron microscopy. The resultant gold materials were drastically different and dependent on the thermolysed complex.
Armitage, CW, O'Meara, CP, Bryan, ER, Kollipara, A, Trim, LK, Hickey, D, Carey, AJ, Huston, WM, Donnelly, G, Yazdani, A, Blumberg, RS & Beagley, KW 2024, 'IgG exacerbates genital chlamydial pathology in females by enhancing pathogenic CD8+ T cell responses', Scandinavian Journal of Immunology, vol. 99, no. 1.
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AbstractChlamydia trachomatis infections are an important sexually transmitted infection that can lead to inflammation, scarring and hydrosalpinx/infertility. However, infections are commonly clinically asymptomatic and do not receive treatment. The underlying cause of asymptomatic immunopathology remains unknown. Here, we demonstrate that IgG produced during male infection enhanced the incidence of immunopathology and infertility in females. Human endocervical cells expressing the neonatal Fc Receptor (FcRn) increased translocation of human IgG‐opsonized C. trachomatis. Using total IgG purified from infected male mice, we opsonized C. muridarum and then infected female mice, mimicking sexual transmission. Following infection, IgG‐opsonized Chlamydia was found to transcytose the epithelial barrier in the uterus, where it was phagocytosed by antigen‐presenting cells (APCs) and trafficked to the draining lymph nodes. APCs then expanded both CD4+ and CD8+ T cell populations and caused significantly more infertility in female mice infected with non‐opsonized Chlamydia. Enhanced phagocytosis of IgG‐opsonized Chlamydia significantly increased pro‐inflammatory signalling and T cell proliferation. As IgG is transcytosed by FcRn, we utilized FcRn−/− mice and observed that shedding kinetics of Chlamydia were only affected in FcRn−/− mice infected with IgG‐opsonized Chlamydia. Depletion of CD8+ T cells in FcRn−/− mice lead to a significant reduction in the incidence of infertility. Taken together, these data demonstrate that IgG seroconversion during male infection can amplify female immunopathol...
Ashique, S, Mishra, N, Garg, A, Garg, S, Farid, A, Rai, S, Gupta, G, Kamal, D, Paudel, KR & Taghizadeh-Hesary, F 2024, 'A Critical Review on the Long-term COVID-19 Impacts on Patients with Diabetes', The American Journal of Medicine.
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Bahatheg, G, Kuppusamy, R, Yasir, M, Bridge, S, Mishra, SK, Cranfield, CG, StC. Black, D, Willcox, M & Kumar, N 2024, 'Dimeric peptoids as antibacterial agents', Bioorganic Chemistry, vol. 147, pp. 107334-107334.
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Balzer, MJ, Hitchcock, JN, Kobayashi, T, Westhorpe, DP, Boys, C & Mitrovic, SM 2024, 'Flow event size influences carbon, nutrient and zooplankton dynamics in a highly regulated lowland river', Hydrobiologia, vol. 851, no. 5, pp. 1319-1334.
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AbstractRiver regulation and water extraction has significantly altered flow regimes and reduced flood events in many inland river systems. Environmental flows have been adopted in many systems to mitigate the ecological impacts of river regulation, however a lack of knowledge regarding the interrelationship between flow regimes, carbon transport and instream productivity make prioritising water management difficult. To address this knowledge gap, we conducted a study on the Namoi River in the Murray-Darling Basin, Australia, monitoring changes in dissolved organic carbon (DOC), nutrient dynamics and planktonic food web structure during a period of variable flows. Nutrient and DOC concentrations were positively correlated with river discharge and zooplankton concentrations were highest post flow events. Planktonic chlorophyll-a, increased DOC concentration and higher discharge were the most influential drivers of change in zooplankton communities. Further, our results indicated that flow events increased production through both heterotrophic and autotrophic pathways, significantly boosting zooplankton concentration compared to base flow conditions across all measured flow events. We suggest even small in-channel flow events can be important for increasing basal and zooplankton production in rivers, and therefore should be protected or promoted by environmental flow management, particularly during drought conditions.
Banik, M, Paudel, KR, Majumder, R & Idrees, S 2024, 'Prediction of virus–host interactions and identification of hot spot residues of DENV-2 and SH3 domain interactions', Archives of Microbiology, vol. 206, no. 4.
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AbstractDengue virus, particularly serotype 2 (DENV-2), poses a significant global health threat, and understanding the molecular basis of its interactions with host cell proteins is imperative for developing targeted therapeutic strategies. This study elucidated the interactions between proline-enriched motifs and Src homology 3 (SH3) domain. The SH3 domain is pivotal in mediating protein–protein interactions, particularly by recognizing and binding to proline-rich regions in partner proteins. Through a computational pipeline, we analyzed the interactions and binding modes of proline-enriched motifs with SH3 domains, identified new potential DENV-2 interactions with the SH3 domain, and revealed potential hot spot residues, underscoring their significance in the viral life cycle. This comprehensive analysis provides crucial insights into the molecular basis of DENV-2 infection, highlighting conserved and serotype-specific interactions. The identified hot spot residues offer potential targets for therapeutic intervention, laying the foundation for developing antiviral strategies against Dengue virus infection. These findings contribute to the broader understanding of viral–host interactions and provide a roadmap for future research on Dengue virus pathogenesis and treatment.
Barash, M, McNevin, D, Fedorenko, V & Giverts, P 2024, 'Machine learning applications in forensic DNA profiling: A critical review', Forensic Science International: Genetics, vol. 69, pp. 102994-102994.
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Bartels, N, Camp, EF, Dilernia, NJ & Suggett, DJ 2024, 'Regulation of cultured coral endosymbiont photophysiology by alternate heat stress protocols', Marine Biology, vol. 171, no. 1.
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Bashir, B, Alam, S, Khandale, N, Birla, D, Vishwas, S, Pandey, NK, Gupta, G, Paudel, KR, Dureja, H, Kumar, P, Singh, TG, Kuppusamy, G, Zacconi, FC, Pinto, TDJA, Dhanasekaran, M, Gulati, M, Dua, K & Singh, SK 2024, 'Opening avenues for treatment of neurodegenerative disease using post-biotics: Breakthroughs and bottlenecks in clinical translation', Ageing Research Reviews, vol. 95, pp. 102236-102236.
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Bhat, AA, Afzal, M, Goyal, A, Gupta, G, Thapa, R, almalki, WH, Kazmi, I, Alzarea, SI, Shahwan, M, Paudel, KR, Ali, H, Sahu, D, Prasher, P, Singh, SK & Dua, K 2024, 'The impact of formaldehyde exposure on lung inflammatory disorders: Insights into asthma, bronchitis, and pulmonary fibrosis', Chemico-Biological Interactions, vol. 394, pp. 111002-111002.
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Boyton, I, Valenzuela, SM, Collins-Praino, LE & Care, A 2024, 'Neuronanomedicine for Alzheimer’s and Parkinson’s disease: Current progress and a guide to improve clinical translation', Brain, Behavior, and Immunity, vol. 115, pp. 631-651.
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Neuronanomedicine is an emerging multidisciplinary field that aims to create innovative nanotechnologies to treat major neurodegenerative disorders, such as Alzheimer's (AD) and Parkinson's disease (PD). A key component of neuronanomedicine are nanoparticles, which can improve drug properties and demonstrate enhanced safety and delivery across the blood brain barrier, a major improvement on existing therapeutic approaches. In this review, we critically analyze the latest nanoparticle-based strategies to modify underlying disease pathology to slow or halt AD/PD progression. We find that a major roadblock for neuronanomedicine translation to date is a poor understanding of how nanoparticles interact with biological systems (i.e., bio-nano interactions), which is partly due to inconsistent reporting in published works. Accordingly, this review makes a set of specific recommendations to help guide researchers to harness the unique properties of nanoparticles and thus realise breakthrough treatments for AD/PD.
Bradfield, LA, Becchi, S & Kendig, MD 2024, 'Striatal Acetylcholine and Dopamine Interactions Produce Situationappropriate Action Selection', Current Neuropharmacology, vol. 22, no. 9, pp. 1491-1496.
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Abstract:Individuals often learn how to perform new actions for particular outcomes against a complex background of existing action-outcome associations. As such, this new knowledge can interfere or even compete with existing knowledge, such that individuals must use internal and external cues to determine which action is appropriate to the current situation. The question thus remains as to how this problem is solved at a neural level. Research over the last decade or so has begun to determine how the brain achieves situation-appropriate action selection. Several converging lines of evidence suggest that it is achieved through the complex interactions of acetylcholine and dopamine within the striatum in a manner that relies on glutamatergic inputs from the cortex and thalamus. Here we briefly review this evidence, then relate it to several very recent findings to provide new, speculative insights regarding the precise nature of striatal acetylcholine/dopamine interaction dynamics and their relation to situation-appropriate action selection.
Brown, AO, Green, PJ, Frankham, GJ, Stuart, BH & Ueland, M 2024, 'Correction to “Insights into the Effects of Violating Statistical Assumptions for Dimensionality Reduction for Chemical “-omics” Data with Multiple Explanatory Variables”', ACS Omega, vol. 9, no. 13, pp. 15724-15724.
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Buckley, T, Vuong, T, Karanam, K, Vo, PHN, Shukla, P, Firouzi, M & Rudolph, V 2024, 'Response to ‘Comment on “Using foam fractionation to estimate PFAS air-water interface adsorption behaviour at ng/L and µg/L” by T. Buckley, T. Vuong, K. Karanam, P.H.N. Vo, P. Shukla, M. Firouzi & V. Rudolph, Water research 239, 120028’', Water Research, vol. 249, pp. 120811-120811.
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Carter, DJ, Rahmani, A, Evans, R, Stratigos, A & Brown, J 2024, 'HIV-related Legal Needs, Demographic Change, and Trends in Australia since 1992: A Review of Legal Administrative Data', AIDS and Behavior, vol. 28, no. 2, pp. 574-582.
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Chen, J, Zhang, G, Xiao, J, Li, J, Xiao, Y, Zhang, D, Gao, H, Guo, X, Wang, G & Liu, H 2024, 'A Stress Self‐Adaptive Bimetallic Stellar Nanosphere for High‐Energy Sodium‐Ion Batteries', Advanced Functional Materials, vol. 34, no. 1.
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AbstractBimetallic composites exhibit great potential as anode materials in advanced energy storage systems owing to their inherent tunability, cost‐effectiveness, and simultaneous achievement of high specific capacity and low reaction potential. However, simple biphase mixing often fails to achieve satisfactory performance. Herein, an innovative stress self‐adaptive bimetallic stellar nanosphere (50–200 nm) wherein bismuth (Bi) is fabricated, as a core, is seamlessly encapsulated by a tin (Sn) sneath (Sn‐Bi@C). This well‐integrated stellar configuration with bimetallic nature embodies the synergy between Bi and Sn, offering fortified conductivity and heightened sodium ion diffusion kinetics. Moreover, through meticulous utilization of finite element analysis simulations, a homogeneous stress distribution within the Sn‐enveloped Bi, efficiently mitigating the structural strain raised from the insertion of Na+ ions, is uncovered. The corresponding electrode demonstrates remarkable cyclic stability, as it exhibits no capacity decay after 100 cycles at 0.1 A g−1. Furthermore, it achieves an impressive 86.9% capacity retention even after an extensive 2000 cycles. When employed in a Na3V2(PO4)3 ‖ Sn‐Bi@C full cell configuration, it demonstrates exceptional capacity retention of 97.06% after 300 cycles at 1 A g−1, along with a high energy density of 251.2 W h kg−1.
Choi, V, Park, SB, Lacey, J, Kumar, S, Heller, G & Grimison, P 2024, 'Electroacupuncture use for treatment of taxane-induced peripheral neuropathy in patients with breast cancer: protocol for a pilot, randomised, blinded, sham-controlled trial (EA for CIPN)', BMJ Open, vol. 14, no. 1, pp. e076391-e076391.
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IntroductionChemotherapy-induced peripheral neuropathy (CIPN) is a common dose-limiting side effect of neurotoxic chemotherapy. Acute symptoms of CIPN during treatment can lead to dose reduction and cessation. Trials using electroacupuncture (EA) to treat established CIPN postchemotherapy have shown some efficacy. The current trial aims to assess the feasibility and preliminary efficacy of using EA to treat CIPN during chemotherapy.Methods and analysisThe current study is a single-centre, 1:1 randomised, sham-controlled pilot study set in a tertiary cancer hospital in Sydney, Australia, and will recruit 40 adult patients with early breast cancer undergoing adjuvant or neoadjuvant paclitaxel chemotherapy. Patients who develop CIPN within the first 6 weeks of chemotherapy will receive either true EA or sham-EA once a week for 10 weeks. The coprimary endpoints are recruitment and adherence rate, successful blinding of patients and compliance with the follow-up period. Secondary endpoints are mean change of CIPN symptoms from randomisation to end of treatment, sustained change in CIPN symptoms at 8-week and 24-week follow-up postchemotherapy, proportion of subjects attaining completion of 12 weeks of chemotherapy without dose reduction or cessation, change in acupuncture expectancy response pretreatment, during treatment and posttreatment. The primary assessment tool for the secondary endpoints will be a validated patient-reported outcome measure (European Organisation for Research and Treatment of Cancer Quality of Life Chemotherapy-Induced Peripheral Neuropathy) captured weekly from randomisation to week 12 of chemotherapy.Ethics and disseminationThe study protocol (2021/ETH12123) has been approved by the institutional Human Research Ethics Committee at St Vincent’s Hospital Sydney and Chr...
Chowdhury, S, Sais, D, Donnelly, S & Tran, N 2024, 'The knowns and unknowns of helminth–host miRNA cross-kingdom communication', Trends in Parasitology, vol. 40, no. 2, pp. 176-191.
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Clark, K, Boland, JW & Currow, DC 2024, 'Letter to the Editor. A Response to: Palliative Management of Inoperable Malignant Bowel Obstruction: Prospective, Open Label, Phase 2 Study at an NCI Comprehensive Cancer Center.', Journal of pain and symptom management, vol. 8, no. 4, pp. 0885-3924(24)00064-2-5.
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Clover Ree, L, de la Hunty, M, Moret, S & Chadwick, S 2024, 'An investigation into the effect of surfactants on iron oxide powder suspension formulations for fingermark development', Forensic Science International, vol. 358, pp. 112019-112019.
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Cook, AM, Rezende, EL, Petrou, K & Leigh, A 2024, 'Beyond a single temperature threshold: Applying a cumulative thermal stress framework to plant heat tolerance', Ecology Letters, vol. 27, no. 3.
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AbstractMost plant thermal tolerance studies focus on single critical thresholds, which limit the capacity to generalise across studies and predict heat stress under natural conditions. In animals and microbes, thermal tolerance landscapes describe the more realistic, cumulative effects of temperature. We tested this in plants by measuring the decline in leaf photosynthetic efficiency (FV/FM) following a combination of temperatures and exposure times and then modelled these physiological indices alongside recorded environmental temperatures. We demonstrate that a general relationship between stressful temperatures and exposure durations can be effectively employed to quantify and compare heat tolerance within and across plant species and over time. Importantly, we show how FV/FM curves translate to plants under natural conditions, suggesting that environmental temperatures often impair photosynthetic function. Our findings provide more robust descriptors of heat tolerance in plants and suggest that heat tolerance in disparate groups of organisms can be studied with a single predictive framework.
Cotter, DJ, Severson, AL, Kang, JTL, Godrej, HN, Carmi, S & Rosenberg, NA 2024, 'Modeling the effects of consanguinity on autosomal and X-chromosomal runs of homozygosity and identity-by-descent sharing', G3: Genes, Genomes, Genetics, vol. 14, no. 2.
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Abstract Runs of homozygosity (ROH) and identity-by-descent (IBD) sharing can be studied in diploid coalescent models by noting that ROH and IBD-sharing at a genomic site are predicted to be inversely related to coalescence times—which in turn can be mathematically obtained in terms of parameters describing consanguinity rates. Comparing autosomal and X-chromosomal coalescent models, we consider ROH and IBD-sharing in relation to consanguinity that proceeds via multiple forms of first-cousin mating. We predict that across populations with different levels of consanguinity, (1) in a manner that is qualitatively parallel to the increase of autosomal IBD-sharing with autosomal ROH, X-chromosomal IBD-sharing increases with X-chromosomal ROH, owing to the dependence of both quantities on consanguinity levels; (2) even in the absence of consanguinity, X-chromosomal ROH and IBD-sharing levels exceed corresponding values for the autosomes, owing to the smaller population size and lower coalescence time for the X chromosome than for autosomes; (3) with matrilateral consanguinity, the relative increase in ROH and IBD-sharing on the X chromosome compared to the autosomes is greater than in the absence of consanguinity. Examining genome-wide SNPs in human populations for which consanguinity levels have been estimated, we find that autosomal and X-chromosomal ROH and IBD-sharing levels generally accord with the predictions. We find that each 1% increase in autosomal ROH is associated with an increase of 2.1% in X-chromosomal ROH, and each 1% increase in autosomal IBD-sharing is associated with an increase of 1.6% in X-chromosomal IBD-sharing. For each calculation, particularly for ROH, the estimate is reasonably close to the increase of 2% predicted by the population-size difference between autosomes and X chromosomes. The results support the utility of coalescent models for understanding patterns of genomic sharing an...
Dawson, BM, Ueland, M, Carter, DO, Mclntyre, D & Barton, PS 2024, 'Bridging the gap between decomposition theory and forensic research on postmortem interval', International Journal of Legal Medicine, vol. 138, no. 2, pp. 509-518.
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AbstractKnowledge of the decomposition of vertebrate animals has advanced considerably in recent years and revealed complex interactions among biological and environmental factors that affect rates of decay. Yet this complexity remains to be fully incorporated into research or models of the postmortem interval (PMI). We suggest there is both opportunity and a need to use recent advances in decomposition theory to guide forensic research and its applications to understanding the PMI. Here we synthesise knowledge of the biological and environmental factors driving variation in decomposition and the acknowledged limitations among current models of the PMI. To guide improvement in this area, we introduce a conceptual framework that highlights the multiple interdependencies affecting decay rates throughout the decomposition process. Our framework reinforces the need for a multidisciplinary approach to PMI research, and calls for an adaptive research cycle that aims to reduce uncertainty in PMI estimates via experimentation, modelling, and validation.
De Rubis, G, Paudel, KR, Allam, VSRR, Malyla, V, Subramaniyan, V, Singh, SK, Panth, N, Gupta, G, Hansbro, PM, Chellappan, DK & Dua, K 2024, 'Involvement of osteopontin, EpCAM, estrogen receptor-alpha, and carbonic anhydrase IX protein in managing lung cancer via Berberine-loaded liquid crystalline nanoparticles', Pathology - Research and Practice, vol. 253, pp. 154971-154971.
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De Rubis, G, Paudel, KR, Yeung, S, Agarwal, V, Hansbro, PM, Oliver, BGG & Dua, K 2024, 'Ribavirin attenuates carcinogenesis by downregulating IL-6 and IL-8 in vitro in human lung adenocarcinoma', Pathology - Research and Practice, vol. 253, pp. 155038-155038.
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De Rubis, G, Paudel, KR, Yeung, S, Mohamad, S, Sudhakar, S, Singh, SK, Gupta, G, Hansbro, PM, Chellappan, DK, Oliver, BGG & Dua, K 2024, '18-β-glycyrrhetinic acid-loaded polymeric nanoparticles attenuate cigarette smoke-induced markers of impaired antiviral response in vitro', Pathology - Research and Practice, vol. 257, pp. 155295-155295.
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Dilernia, NJ, Woodcock, S, Camp, EF, Hughes, DJ, Kühl, M & Suggett, DJ 2024, 'Intra‐colony spatial variance of oxyregulation and hypoxic thresholds for key Acropora coral species', Ecology and Evolution, vol. 14, no. 3, p. e11100.
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AbstractOxygen (O2) availability is essential for healthy coral reef functioning, yet how continued loss of dissolved O2 via ocean deoxygenation impacts performance of reef building corals remains unclear. Here, we examine how intra‐colony spatial geometry of important Great Barrier Reef (GBR) coral species Acropora may influence variation in hypoxic thresholds for upregulation, to better understand capacity to tolerate future reductions in O2 availability. We first evaluate the application of more streamlined models used to parameterise Hypoxia Response Curve data, models that have been used historically to identify variable oxyregulatory capacity. Using closed‐system respirometry to analyse O2 drawdown rate, we show that a two‐parameter model returns similar outputs as previous 12th‐order models for descriptive statistics such as the average oxyregulation capacity (Tpos) and the ambient O2 level at which the coral exerts maximum regulation effort (Pcmax), for diverse Acropora species. Following an experiment to evaluate whether stress induced by coral fragmentation for respirometry affected O2 drawdown rate, we subsequently identify differences in hypoxic response for the interior and exterior colony locations for the species Acropora abrotanoides, Acropora cf. microphthalma and Acropora elseyi. Average regulation capacity across species was greater (0.78–1.03 ± SE 0.08) at the colony interior compared with exterior (0.60–0.85 ± SE 0.08). Moreover, Pcmax occurred at relatively low pO2 of <30% (±1.24; SE) air saturation for a...
Ding, L, Chen, C, Shan, X, Liu, B, Wang, D, Du, Z, Zhao, G, Su, QP, Yang, Y, Halkon, B, Tran, TT, Liao, J, Aharonovich, I, Zhang, M, Cheng, F, Fu, L, Xu, X & Wang, F 2024, 'Optical Nonlinearity Enabled Super‐Resolved Multiplexing Microscopy', Advanced Materials, vol. 36, no. 2.
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AbstractOptical multiplexing for nanoscale object recognition is of great significance within the intricate domains of biology, medicine, anti‐counterfeiting, and microscopic imaging. Traditionally, the multiplexing dimensions of nanoscopy are limited to emission intensity, color, lifetime, and polarization. Here, a novel dimension, optical nonlinearity, is proposed for super‐resolved multiplexing microscopy. This optical nonlinearity is attributable to the energy transitions between multiple energy levels of the doped lanthanide ions in upconversion nanoparticles (UCNPs), resulting in unique optical fingerprints for UCNPs with different compositions. A vortex beam is applied to transport the optical nonlinearity onto the imaging point‐spread function (PSF), creating a robust super‐resolved multiplexing imaging strategy for differentiating UCNPs with distinctive optical nonlinearities. The composition information of the nanoparticles can be retrieved with variations of the corresponding PSF in the obtained image. Four channels multiplexing super‐resolved imaging with a single scanning, applying emission color and nonlinearity of two orthogonal imaging dimensions with a spatial resolution higher than 150 nm (1/6.5λ), are demonstrated. This work provides a new and orthogonal dimension – optical nonlinearity – to existing multiplexing dimensions, which shows great potential in bioimaging, anti‐counterfeiting, microarray assays, deep tissue multiplexing detection, and high‐density data storage.
Ding, L, Chen, C, Shan, X, Liu, B, Wang, D, Du, Z, Zhao, G, Su, QP, Yang, Y, Halkon, B, Tran, TT, Liao, J, Aharonovich, I, Zhang, M, Cheng, F, Fu, L, Xu, X & Wang, F 2024, 'Optical Nonlinearity Enabled Super‐Resolved Multiplexing Microscopy (Adv. Mater. 2/2024)', Advanced Materials, vol. 36, no. 2.
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Dunbar, A, Drigo, B, Djordjevic, SP, Donner, E & Hoye, BJ 2024, 'Impacts of coprophagic foraging behaviour on the avian gut microbiome', Biological Reviews, vol. 99, no. 2, pp. 582-597.
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ABSTRACTAvian gut microbial communities are complex and play a fundamental role in regulating biological functions within an individual. Although it is well established that diet can influence the structure and composition of the gut microbiota, foraging behaviour may also play a critical, yet unexplored role in shaping the composition, dynamics, and adaptive potential of avian gut microbiota. In this review, we examine the potential influence of coprophagic foraging behaviour on the establishment and adaptability of wild avian gut microbiomes. Coprophagy involves the ingestion of faeces, sourced from either self (autocoprophagy), conspecific animals (allocoprophagy), or heterospecific animals. Much like faecal transplant therapy, coprophagy may (i) support the establishment of the gut microbiota of young precocial species, (ii) directly and indirectly provide nutritional and energetic requirements, and (iii) represent a mechanism by which birds can rapidly adapt the microbiota to changing environments and diets. However, in certain contexts, coprophagy may also pose risks to wild birds, and their microbiomes, through increased exposure to chemical pollutants, pathogenic microbes, and antibiotic‐resistant microbes, with deleterious effects on host health and performance. Given the potentially far‐reaching consequences of coprophagy for avian microbiomes, and the dearth of literature directly investigating these links, we have developed a predictive framework for directing future research to understand better when and why wild birds engage in distinct types of coprophagy, and the consequences of this foraging behaviour. There is a need for comprehensive investigation into the influence of coprophagy on avian gut microbiotas and its effects on host health and performance throughout ontogeny and across a range of environmental perturbations. Fu...
Duncan, RJ, Nielsen, D, Søreide, JE, Varpe, Ø, Tobin, MJ, Pitusi, V, Heraud, P & Petrou, K 2024, 'Biomolecular profiles of Arctic sea-ice diatoms highlight the role of under-ice light in cellular energy allocation', ISME Communications, vol. 4, no. 1.
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Abstract Arctic sea-ice diatoms fuel polar marine food webs as they emerge from winter darkness into spring. Through their photosynthetic activity they manufacture the nutrients and energy that underpin secondary production. Sea-ice diatom abundance and biomolecular composition vary in space and time. With climate change causing short-term extremes and long-term shifts in environmental conditions, understanding how and in what way diatoms adjust biomolecular stores with environmental perturbation is important to gain insight into future ecosystem energy production and nutrient transfer. Using synchrotron-based Fourier transform infrared microspectroscopy, we examined the biomolecular composition of five dominant sea-ice diatom taxa from landfast ice communities covering a range of under-ice light conditions during spring, in Svalbard, Norway. In all five taxa, we saw a doubling of lipid and fatty acid content when light transmitted to the ice–water interface was >5% but <15% (85%–95% attenuation through snow and ice). We determined a threshold around 15% light transmittance after which biomolecular synthesis plateaued, likely because of photoinhibitory effects, except for Navicula spp., which continued to accumulate lipids. Increasing under-ice light availability led to increased energy allocation towards carbohydrates, but this was secondary to lipid synthesis, whereas protein content remained stable. It is predicted that under-ice light availability will change in the Arctic, increasing because of sea-ice thinning and potentially decreasing with higher snowfall. Our findings show that the nutritional content of sea-ice diatoms is taxon-specific and linked to these changes, highlighting potential implications for future energy and nutrient supply for the polar marine food web.
Ellis, JT & Stothard, JR 2024, 'Celebrating 150 volumes of Parasitology with an outlook towards 2030 production', Parasitology, vol. 151, no. 3, pp. 247-250.
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Espinoza-Corral, R, Iwai, M, Zavřel, T, Lechno-Yossef, S, Sutter, M, Červený, J, Niyogi, KK & Kerfeld, CA 2024, 'Phycobilisome protein ApcG interacts with PSII and regulates energy transfer in Synechocystis', Plant Physiology, vol. 194, no. 3, pp. 1383-1396.
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Abstract Photosynthetic organisms harvest light using pigment–protein complexes. In cyanobacteria, these are water-soluble antennae known as phycobilisomes (PBSs). The light absorbed by PBS is transferred to the photosystems in the thylakoid membrane to drive photosynthesis. The energy transfer between these complexes implies that protein–protein interactions allow the association of PBS with the photosystems. However, the specific proteins involved in the interaction of PBS with the photosystems are not fully characterized. Here, we show in Synechocystis sp. PCC 6803 that the recently discovered PBS linker protein ApcG (sll1873) interacts specifically with PSII through its N-terminal region. Growth of cyanobacteria is impaired in apcG deletion strains under light-limiting conditions. Furthermore, complementation of these strains using a phospho-mimicking version of ApcG causes reduced growth under normal growth conditions. Interestingly, the interaction of ApcG with PSII is affected when a phospho-mimicking version of ApcG is used, targeting the positively charged residues interacting with the thylakoid membrane, suggesting a regulatory role mediated by phosphorylation of ApcG. Low-temperature fluorescence measurements showed decreased PSI fluorescence in apcG deletion and complementation strains. The PSI fluorescence was the lowest in the phospho-mimicking complementation strain, while the pull-down experiment showed no interaction of ApcG with PSI under any tested condition. Our results highlight the importance of ApcG for selectively directing energy harvested by the PBS and imply that the phosphorylation status of ApcG plays a role in regulating energy transfer from PSII to PSI.
Fairley, LH, Grimm, A, Herff, SA & Eckert, A 2024, 'Translocator protein (TSPO) ligands attenuate mitophagy deficits in the SH-SY5Y cellular model of Alzheimer's disease via the autophagy adaptor P62', Biochimie.
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Faiz, A, Wiersma, VR, Salzbrunn, JB, Brandsma, C-A, Timens, W, Burgess, JK, van den Berge, M, Slebos, D-J, Guryev, V & Pouwels, SD 2024, 'COPD Patients Display Increased Peripheral Blood Somatic Mutations Which Associate With the Prevalence of Co-morbidities', Archivos de Bronconeumología, vol. 60, no. 2, pp. 119-121.
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Feary, DA, Fowler, AM & Booth, DJ 2024, 'Predator-avoidance behaviour of target and non-target temperate reef fishes is lower in areas protected from fishing', Marine Biology, vol. 171, no. 3.
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AbstractThe effects of hunting on predator-avoidance behaviour are increasingly being recognised on land but have received less attention in marine systems. We examined whether predator-avoidance behaviour of temperate reef fishes differed between areas protected and not protected from recreational fishing by examining the flight-initiation distance (FID; the distance a predator can approach before the prey animal flees) of six common species in southeastern Australia. By testing species that ranged in desirability to recreational fishers, we could determine if behavioural differences were specific to target species or extended more broadly throughout the assemblage. After accounting for potential variability among sites within protection levels, we found that the FID of all species was higher in fished areas than protected areas, with FID up to 2.4 times higher in fished areas. The two commonly targeted species had the greatest FID response to fishing. FID also increased with body size for all but one species. Our findings indicate the potential for assemblage-wide effects of fishing on predator-avoidance behaviour and are consistent with an indirect mechanism of behavioural modification.
Fitschen, LJ, Newing, TP, Johnston, NP, Bell, CE & Tolun, G 2024, 'Half a century after their discovery: Structural insights into exonuclease and annealase proteins catalyzing recombineering', Engineering Microbiology, vol. 4, no. 1, pp. 100120-100120.
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Freedman, LS, Wang, C-Y, Commins, J, Barrett, B, Midthune, D, Dodd, KW, Carroll, RJ & Kipnis, V 2024, 'Can sodium and potassium measured in timed voids be used as reference instruments for validating self-report instruments? Results from a urine calibration study', The American Journal of Clinical Nutrition.
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Fursman, H, Finch, E, Xiao, L, Lefrançois, E, Gupta, A, Bartlett, M, Latimer, J, Chadwick, S, Roux, C & Morelato, M 2024, 'A snapshot of injecting drug consumption from the analysis of used syringes within the Medically Supervised Injecting Centre in Sydney, Australia', Drug and Alcohol Review, vol. 43, no. 3, pp. 787-798.
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AbstractIntroductionThe administration of illicit drugs by injection is associated with considerable harm, including an increased risk of overdose. The chemical analysis of used syringes can enhance knowledge on injecting drug consumption beyond traditional data sources (self‐report surveys). This additional information may be useful during significant global events like the COVID‐19 pandemic. This study aimed to examine a snapshot of the drugs injected at the Medically Supervised Injecting Centre (MSIC) in Sydney, Australia, in 2019–2020.MethodsUsed syringes were collected from MSIC across three periods throughout 2019 and 2020 (February 2019, March—April 2020 and June—September 2020). Drug residues were extracted from used syringes using methanol before detection by gas chromatography—mass spectrometry and ultra‐performance liquid chromatography—tandem mass spectrometry. The chemical analysis results were compared to self‐report data obtained from MSIC clients.ResultsHeroin (46–53%), methamphetamine (24–34%) and pharmaceutical opioids (15–27%) were the most common drug residues detected. The chemically detected drugs had declining coherence with the drugs self‐reported by MSIC clients across the time periods examined.Discussion and ConclusionsThere was no significant change in the drugs injected (heroin, methamphetamine and pharmaceutical opioids) across the three periods collected throughout varying COVID‐19 lockdown restrictions. Changes in the frequency of other drugs injected and discrepancies between chemical analysis and self‐report were potentially related to regulatory changes, degradation or misinformed sales. Routine chemical analysis of used syringes has provided an alternative informatio...
Ganio, K, Nasreen, M, Yang, Z, Maunders, EA, Luo, Z, Hossain, SI, Ngu, DHY, Ellis, D, Gu, J, Neville, SL, Wilksch, J, Gunn, AP, Whittall, JJ, Kobe, B, Deplazes, E, Kappler, U & McDevitt, CA 2024, 'Hfe Permease and Haemophilus influenzae Manganese Homeostasis', ACS Infectious Diseases, vol. 10, no. 2, pp. 436-452.
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Gill, RL, Fleck, R, Chau, K, Westerhausen, MT, Lockwood, TE, Violi, JP, Irga, PJ, Doblin, MA & Torpy, FR 2024, 'Fine particle pollution during megafires contains potentially toxic elements', Environmental Pollution, vol. 344, pp. 123306-123306.
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Gomez, HM, Haw, TJ, Ilic, D, Robinson, P, Donovan, C, Croft, AJ, Vanka, KS, Small, E, Carroll, OR, Kim, RY, Mayall, JR, Beyene, T, Palanisami, T, Ngo, DTM, Zosky, GR, Holliday, EG, Jensen, ME, McDonald, VM, Murphy, VE, Gibson, P & Horvat, JC 2024, 'Landscape fire smoke airway exposure impairs respiratory and cardiac function and worsens experimental asthma', Journal of Allergy and Clinical Immunology.
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Gunawan, C, Fleming, C, Irga, PJ, Jien Wong, R, Amal, R, Torpy, FR, Mojtaba Golzan, S & McGrath, KC 2024, 'Neurodegenerative effects of air pollutant Particles: Biological mechanisms implicated for Early-Onset Alzheimer’s disease', Environment International, vol. 185, pp. 108512-108512.
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Hall, LM, Munasinghe, VS, Vella, NGF, Ellis, JT & Stark, D 2024, 'Observations on the transmission of Dientamoeba fragilis and the cyst life cycle stage', Parasitology, vol. 151, no. 3, pp. 337-345.
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AbstractLittle is known about the life cycle and mode of transmission of Dientamoeba fragilis. Recently it was suggested that fecal–oral transmission of cysts may play a role in the transmission of D. fragilis. In order to establish an infection, D. fragilis is required to remain viable when exposed to the pH of the stomach. In this study, we investigated the ability of cultured trophozoites to withstand the extremes of pH. We provide evidence that trophozoites of D. fragilis are vulnerable to highly acidic conditions. We also investigated further the ultrastructure of D. fragilis cysts obtained from mice and rats by transmission electron microscopy. These studies of cysts showed a clear cyst wall surrounding an encysted parasite. The cyst wall was double layered with an outer fibrillar layer and an inner layer enclosing the parasite. Hydrogenosomes, endoplasmic reticulum and nuclei were present in the cysts. Pelta-axostyle structures, costa and axonemes were identifiable and internal flagellar axonemes were present. This study therefore provides additional novel details and knowledge of the ultrastructure of the cyst stage of D. fragilis.
Hayes, C, Mitchell, A, Mellin, C, Booth, DJ, Ravasi, T & Nagelkerken, I 2024, 'Ecological generalism and physiology mediate fish biogeographic ranges under ocean warming', Proceedings of the Royal Society B: Biological Sciences, vol. 291, no. 2015, p. 20232206.
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Climate-driven species redistributions are facilitated by niche modifications that increase a species's chances of establishment in novel communities. It is well understood how range-extending species adjust individual niche traits when entering novel environments, yet whether modification of ecological niche traits collectively alters the pace of range extensions or contractions remains unknown. We quantified habitat niche, abundance, physiological performance and cellular defence/damage of range-extending coral reef fishes and coexisting local temperate fishes along a 2000 km latitudinal gradient. We also assessed their dietary and behavioural niches, and establishment potential, to understand whether ecological generalism facilitates successful range extension of coral reef fishes. The coral reef fish that increased all ecological niches, showed stronger establishment, increased physiological performance and cellular damage, but decreased cellular defence at their cold-range edge, whereas tropical species that showed unmodified ecological niches showed lower establishment. One temperate species showed decreased abundance, habitat niche width and body condition, but increased cellular defence, cellular damage and energy reserves at their warm-trailing range, while other temperate species showed contrasting responses. Therefore, ecological generalists might be more successful than ecological specialists during the initial stages of climate change, with increasing future warming strengthening this pattern by physiologically benefitting tropical generalists but disadvantaging temperate specialists.
He, LX, Deng, K, Wang, J, Zhang, X, Wang, L, Zhang, HP, Xie, M, Chen, ZH, Zhang, J, Chen-Yu Hsu, A, Zhang, L, Oliver, BG, Wark, PAB, Qin, L, Gao, P, Wan, HJ, Liu, D, Luo, FM, Li, WM, Wang, G & Gibson, PG 2024, 'Clinical Subtypes of Neutrophilic Asthma: A Cluster Analysis From Australasian Severe Asthma Network', The Journal of Allergy and Clinical Immunology: In Practice, vol. 12, no. 3, pp. 686-698.e8.
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He, Q, Liu, DL, Wang, B, Wang, Z, Cowie, A, Simmons, A, Xu, Z, Li, L, Shi, Y, Liu, K, Harrison, MT, Waters, C, Huete, A & Yu, Q 2024, 'A food-energy-water-carbon nexus framework informs region-specific optimal strategies for agricultural sustainability', Resources, Conservation and Recycling, vol. 203, pp. 107428-107428.
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Hem, S, Cummins, ML, Wyrsch, ER, Drigo, B, Hoye, BJ, Maute, K, Sanderson-Smith, M, Gorman, J, Bogema, DR, Jenkins, C, Deutscher, AT, Yam, J, Hai, F, Donner, E, Jarocki, VM & Djordjevic, SP 2024, 'Genomic analysis of Citrobacter from Australian wastewater and silver gulls reveals novel sequence types carrying critically important antibiotic resistance genes', Science of The Total Environment, vol. 909, pp. 168608-168608.
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Hinners, J, Argyle, PA, Walworth, NG, Doblin, MA, Levine, NM & Collins, S 2024, 'Multi-trait diversification in marine diatoms in constant and warmed environments.', Proc Biol Sci, vol. 291, no. 2019, p. 20232564.
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Phytoplankton are photosynthetic marine microbes that affect food webs, nutrient cycles and climate regulation. Their roles are determined by correlated phytoplankton functional traits including cell size, chlorophyll content and cellular composition. Here, we explore patterns of evolution in interrelated trait values and correlations. Because both chance events and natural selection contribute to phytoplankton trait evolution, we used population bottlenecks to diversify six genotypes of Thalassiosirid diatoms. We then evolved them as large populations in two environments. Interspecific variation and within-species evolution were visualized for nine traits and their correlations using reduced axes (a trait-scape). Our main findings are that shifts in trait values resulted in movement of evolving populations within the trait-scape in both environments, but were more frequent when large populations evolved in a novel environment. Which trait relationships evolved was population-specific, but greater departures from ancestral trait correlations were associated with lower population growth rates. There was no single master trait that could be used to understand multi-trait evolution. Instead, repeatable multi-trait evolution occurred along a major axis of variation defined by several diatom traits and trait relationships. Because trait-scapes capture changes in trait relationships and values together, they offer an insightful way to study multi-trait variation.
Horder, J & Aharonovich, I 2024, 'Optical manipulation of spin resonance in gallium nitride', Nature Photonics, vol. 18, no. 4, pp. 309-310.
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Hossain, MS, Bacaoco, M, Mai, TNA, Ponchon, G, Chen, C, Ding, L, Chen, Y, Ekimov, E, Xu, X, Solntsev, AS & Tran, TT 2024, 'Fiber-Based Ratiometric Optical Thermometry with Silicon Vacancy in Microdiamonds', ACS Applied Optical Materials, vol. 2, no. 1, pp. 97-107.
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Hou, S, Gao, X, Lv, X, Zhao, Y, Yin, X, Liu, Y, Fang, J, Yu, X, Ma, X, Ma, T & Su, D 2024, 'Decade Milestone Advancement of Defect-Engineered g-C3N4 for Solar Catalytic Applications', Nano-Micro Letters, vol. 16, no. 1.
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AbstractOver the past decade, graphitic carbon nitride (g-C3N4) has emerged as a universal photocatalyst toward various sustainable carbo-neutral technologies. Despite solar applications discrepancy, g-C3N4 is still confronted with a general fatal issue of insufficient supply of thermodynamically active photocarriers due to its inferior solar harvesting ability and sluggish charge transfer dynamics. Fortunately, this could be significantly alleviated by the “all-in-one” defect engineering strategy, which enables a simultaneous amelioration of both textural uniqueness and intrinsic electronic band structures. To this end, we have summarized an unprecedently comprehensive discussion on defect controls including the vacancy/non-metallic dopant creation with optimized electronic band structure and electronic density, metallic doping with ultra-active coordinated environment (M–Nx, M–C2N2, M–O bonding), functional group grafting with optimized band structure, and promoted crystallinity with extended conjugation π system with weakened interlayered van der Waals interaction. Among them, the defect states induced by various defect types such as N vacancy, P/S/halogen dopants, and cyano group in boosting solar harvesting and accelerating photocarrier transfer have also been emphasized. More importantly, the shallow defect traps identified by femtosecond transient absorption spectra (fs-TAS) have also been highlighted. It is believed that this review would pave the way for future readers with a unique insight into a more precise defective g-C3N4 “customization”, motivating more profound thinking and flourishing research outputs on g-C3N4-based photoca...
Huang, JE, Chen, Y, Ou, P, Ding, X, Yan, Y, Dorakhan, R, Lum, Y, Li, X-Y, Bai, Y, Wu, C, Fan, M, Lee, MG, Miao, RK, Liu, Y, O’Brien, C, Zhang, J, Tian, C, Liang, Y, Xu, Y, Luo, M, Sinton, D & Sargent, EH 2024, 'Selective Electrified Propylene-to-Propylene Glycol Oxidation on Activated Rh-Doped Pd', Journal of the American Chemical Society, vol. 146, no. 12, pp. 8641-8649.
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Huang, Z, Farahmandjou, M, Marlton, F, Guo, X, Gao, H, Sun, B & Wang, G 2024, 'Surface and structure engineering of MXenes for rechargeable batteries beyond lithium', Journal of Materiomics, vol. 10, no. 1, pp. 253-268.
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Hussain, MS, Altamimi, ASA, Afzal, M, almalki, WH, Kazmi, I, Alzarea, SI, Saleem, S, Prasher, P, Oliver, B, Singh, SK, MacLoughlin, R, Dua, K & Gupta, G 2024, 'From carcinogenesis to therapeutic avenues: lncRNAs and mTOR crosstalk in lung cancer', Pathology - Research and Practice, vol. 253, pp. 155015-155015.
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Idrees, S & Paudel, KR 2024, 'Bioinformatics prediction and screening of viral mimicry candidates through integrating known and predicted DMI data', Archives of Microbiology, vol. 206, no. 1.
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Idrees, S & Paudel, KR 2024, 'Proteome‐wide assessment of human interactome as a source of capturing domain–motif and domain‐domain interactions', Journal of Cell Communication and Signaling, vol. 18, no. 1.
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AbstractProtein–protein interactions (PPIs) play a crucial role in various biological processes by establishing domain–motif (DMI) and domain–domain interactions (DDIs). While the existence of real DMIs/DDIs is generally assumed, it is rarely tested; therefore, this study extensively compared high‐throughput methods and public PPI repositories as sources for DMI and DDI prediction based on the assumption that the human interactome provides sufficient data for the reliable identification of DMIs and DDIs. Different datasets from leading high‐throughput methods (Yeast two‐hybrid [Y2H], Affinity Purification coupled Mass Spectrometry [AP‐MS], and Co‐fractionation‐coupled Mass Spectrometry) were assessed for their ability to capture DMIs and DDIs using known DMI/DDI information. High‐throughput methods were not notably worse than PPI databases and, in some cases, appeared better. In conclusion, all PPI datasets demonstrated significant enrichment in DMIs and DDIs (p‐value <0.001), establishing Y2H and AP‐MS as reliable methods for predicting these interactions. This study provides valuable insights for biologists in selecting appropriate methods for predicting DMIs, ultimately aiding in SLiM discovery.
Idrees, S, Paudel, KR & Hansbro, PM 2024, 'Prediction of motif-mediated viral mimicry through the integration of host–pathogen interactions', Archives of Microbiology, vol. 206, no. 3.
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AbstractOne of the mechanisms viruses use in hijacking host cellular machinery is mimicking Short Linear Motifs (SLiMs) in host proteins to maintain their life cycle inside host cells. In the face of the escalating volume of virus-host protein–protein interactions (vhPPIs) documented in databases; the accurate prediction of molecular mimicry remains a formidable challenge due to the inherent degeneracy of SLiMs. Consequently, there is a pressing need for computational methodologies to predict new instances of viral mimicry. Our present study introduces a DMI-de-novo pipeline, revealing that vhPPIs catalogued in the VirHostNet3.0 database effectively capture domain-motif interactions (DMIs). Notably, both affinity purification coupled mass spectrometry and yeast two-hybrid assays emerged as good approaches for delineating DMIs. Furthermore, we have identified new vhPPIs mediated by SLiMs across different viruses. Importantly, the de-novo prediction strategy facilitated the recognition of several potential mimicry candidates implicated in the subversion of host cellular proteins. The insights gleaned from this research not only enhance our comprehension of the mechanisms by which viruses co-opt host cellular machinery but also pave the way for the development of novel therapeutic interventions.
Idrees, S, Paudel, KR, Sadaf, T & Hansbro, PM 2024, 'Uncovering domain motif interactions using high‐throughput protein–protein interaction detection methods', FEBS Letters, vol. 598, no. 7, pp. 725-742.
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Protein–protein interactions (PPIs) are often mediated by short linear motifs (SLiMs) in one protein and domain in another, known as domain–motif interactions (DMIs). During the past decade, SLiMs have been studied to find their role in cellular functions such as post‐translational modifications, regulatory processes, protein scaffolding, cell cycle progression, cell adhesion, cell signalling and substrate selection for proteasomal degradation. This review provides a comprehensive overview of the current PPI detection techniques and resources, focusing on their relevance to capturing interactions mediated by SLiMs. We also address the challenges associated with capturing DMIs. Moreover, a case study analysing the BioGrid database as a source of DMI prediction revealed significant known DMI enrichment in different PPI detection methods. Overall, it can be said that current high‐throughput PPI detection methods can be a reliable source for predicting DMIs.
Jessamine, V, Mehndiratta, S, De Rubis, G, Paudel, KR, Shetty, S, Suares, D, Chellappan, DK, Oliver, BG, Hansbro, PM & Dua, K 2024, 'The application of nanoparticles as advanced drug delivery systems in Attenuating COPD', Heliyon, vol. 10, no. 3, pp. e25393-e25393.
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Jha, LA, Kumar, B, Jha, SK & Paudel, KR 2024, 'Futuristic senolytic drug incorporated nanomedicine therapy to treat osteoarthritis', Nanomedicine, vol. 19, no. 10, pp. 837-840.
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Jing, L, Deplazes, E, Clegg, JK & Wu, X 2024, 'A charge-neutral organic cage selectively binds strongly hydrated sulfate anions in water', Nature Chemistry, vol. 16, no. 3, pp. 335-342.
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Johnston, NP, Pape, T, Piwczyński, M, Wallman, JF, Wiegmann, BM, Cassel, BK, Akbarzadeh, K & Szpila, K 2024, 'Anchored phylogenomics and revised classification of the Miltogramminae (Diptera: Sarcophagidae)', Systematic Entomology, vol. 49, no. 1, pp. 138-155.
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AbstractThe Miltogramminae (Diptera: Sarcophagidae) includes ~600 species across >40 genera, which constitute ~20% of global Sarcophagidae. While molecular phylogenetic hypotheses have been produced for this group, critical problems persist, including the presence of paraphyletic genera, uncertain relationships between genera, a bias of sampling towards Palaearctic taxa, and low support for many branches. The present study remedies these issues through the application of Anchored Hybrid Enrichment (AHE) to a sample including ~60% of the currently recognised genera (16% of known species) representing all biogeographic regions except the Neotropical. An alignment of 1,281 concatenated loci was analysed with maximum likelihood (RAxML, IQ‐TREE), Bayesian inference (ExaBayes) and coalescent‐based approaches (ASTRAL, SVDquartets), which resulted in highly supported and concordant topologies, providing unprecedented insight into the relationships of this subfamily of flesh flies, allowing a major update to miltogrammine classification. The AHE phylogenetic hypothesis supports the monophyly of a large proportion of genera. The monophyly of Metopia Meigen is restored by synonymy with Aenigmetopia Malloch, syn.n. To achieve monophyly of Miltogramma Meigen, eight species are transferred from Pterella Robineau‐Desvoidy. The genus Pterella is shown to be paraphyletic in its current circumscription, and to restore generic monophyly Pterella is restricted to contain only Pt. grisea (Meigen). Erioprocta Enderlein, stat.rev., is resurrected. The genus Senotainia Macquart is reconstructed as paraphyletic. The monotypic genus Metopodia
Kakoty, V, Sarathlal, KC, Kaur, P, Wadhwa, P, Vishwas, S, Khan, FR, Alhazmi, AYM, Almasoudi, HH, Gupta, G, Chellappan, DK, Paudel, KR, Kumar, D, Dua, K & Singh, SK 2024, 'Unraveling the role of glial cell line–derived neurotrophic factor in the treatment of Parkinson’s disease', Neurological Sciences, vol. 45, no. 4, pp. 1409-1418.
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Karami, H, Kamruzzaman, M, Covington, JA, Hassouna, MÉ, Darvishi, Y, Ueland, M, Fuentes, S & Gancarz, M 2024, 'Advanced evaluation techniques: Gas sensor networks, machine learning, and chemometrics for fraud detection in plant and animal products', Sensors and Actuators A: Physical, vol. 370, pp. 115192-115192.
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Kim, J, Rose, ML, Pierce, JE, Nickels, L, Copland, DA, Togher, L, Godecke, E, Meinzer, M, Rai, T, Hurley, M, Foster, A, Carragher, M, Wilcox, C & Cadilhac, DA 2024, 'High-Intensity Aphasia Therapy Is Cost-Effective in People With Poststroke Aphasia: Evidence From the COMPARE Trial', Stroke, vol. 55, no. 3, pp. 705-714.
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BACKGROUND: Evidence from systematic reviews confirms that speech and language interventions for people with aphasia during the chronic phase after stroke (>6 months) improve word retrieval, functional communication, and communication-related quality of life. However, there is limited evidence of their cost-effectiveness. We aimed to estimate the cost per quality-adjusted life year gained from 2 speech and language therapies compared with usual care in people with aphasia during the chronic phase (median, 2.9 years) after stroke. METHODS: A 3-arm, randomized controlled trial compared constraint-induced aphasia therapy plus (CIAT-Plus) and multimodality aphasia therapy (M-MAT) with usual care in 216 people with chronic aphasia. Participants were administered a standardized questionnaire before intervention and at 12 weeks after the 2-week intervention/control period to ascertain health service utilization, employment changes, and informal caregiver burden. Unit prices from Australian sources were used to estimate costs in 2020. Quality-adjusted life years were estimated using responses to the EuroQol-5 Dimension-3 Level questionnaire. To test uncertainty around the differences in costs and outcomes between groups, bootstrapping was used with the cohorts resampled 1000 times. RESULTS: Overall 201/216 participants were included (mean age, 63 years, 29% moderate or severe aphasia, 61 usual care, 70 CIAT-Plus, 70 M-MAT). There were no statistically significant differences in mean total costs ($13 797 usual care, $17 478 CIAT-Plus, $11 113 M-MAT) and quality-adjusted life years (0.19 usual care, 0.20 CIAT-Plus, 0.20 M-MAT) between groups. In bootstrapped analysis of CIAT-Plus...
Kim, J, Sookram, G, Godecke, E, Brogan, E, Armstrong, E, Ellery, F, Rai, T, Rose, ML, Ciccone, N, Middleton, S, Holland, A, Hankey, GJ, Bernhardt, J & Cadilhac, DA 2024, 'Economic evaluation of the Very Early Rehabilitation in SpEech (VERSE) intervention', Topics in Stroke Rehabilitation, vol. 31, no. 2, pp. 157-166.
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Knights, AM, Lemasson, AJ, Firth, LB, Beaumont, N, Birchenough, S, Claisse, J, Coolen, JWP, Copping, A, De Dominicis, M, Degraer, S, Elliott, M, Fernandes, PG, Fowler, AM, Frost, M, Henry, L-A, Hicks, N, Hyder, K, Jagerroos, S, Love, M, Lynam, C, Macreadie, PI, McLean, D, Marlow, J, Mavraki, N, Montagna, PA, Paterson, DM, Perrow, MR, Porter, J, Bull, AS, Schratzberger, M, Shipley, B, van Elden, S, Vanaverbeke, J, Want, A, Watson, SCL, Wilding, TA & Somerfield, PJ 2024, 'To what extent can decommissioning options for marine artificial structures move us toward environmental targets?', Journal of Environmental Management, vol. 350, pp. 119644-119644.
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Switching from fossil fuels to renewable energy is key to international energy transition efforts and the move toward net zero. For many nations, this requires decommissioning of hundreds of oil and gas infrastructure in the marine environment. Current international, regional and national legislation largely dictates that structures must be completely removed at end-of-life although, increasingly, alternative decommissioning options are being promoted and implemented. Yet, a paucity of real-world case studies describing the impacts of decommissioning on the environment make decision-making with respect to which option(s) might be optimal for meeting international and regional strategic environmental targets challenging. To address this gap, we draw together international expertise and judgment from marine environmental scientists on marine artificial structures as an alternative source of evidence that explores how different decommissioning options might ameliorate pressures that drive environmental status toward (or away) from environmental objectives. Synthesis reveals that for 37 United Nations and Oslo-Paris Commissions (OSPAR) global and regional environmental targets, experts consider repurposing or abandoning individual structures, or abandoning multiple structures across a region, as the options that would most strongly contribute toward targets. This collective view suggests complete removal may not be best for the environment or society. However, different decommissioning options act in different ways and make variable contributions toward environmental targets, such that policy makers and managers would likely need to prioritise some targets over others considering political, social, economic, and ecological contexts. Current policy may not result in optimal outcomes for the environment or society.
Knights, AM, Lemasson, AJ, Firth, LB, Bond, T, Claisse, J, Coolen, JWP, Copping, A, Dannheim, J, De Dominicis, M, Degraer, S, Elliott, M, Fernandes, PG, Fowler, AM, Frost, M, Henry, L-A, Hicks, N, Hyder, K, Jagerroos, S, Jones, DOB, Love, M, Lynam, CP, Macreadie, PI, Marlow, J, Mavraki, N, McLean, D, Montagna, PA, Paterson, DM, Perrow, M, Porter, J, Russell, DJF, Bull, AS, Schratzberger, M, Shipley, B, van Elden, S, Vanaverbeke, J, Want, A, Watson, SCL, Wilding, TA & Somerfield, P 2024, 'Developing expert scientific consensus on the environmental and societal effects of marine artificial structures prior to decommissioning', Journal of Environmental Management, vol. 352, pp. 119897-119897.
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Kokkinis, S, Singh, M, Paudel, KR, De Rubis, G, Bani Saeid, A, Jessamine, V, Datsyuk, J, Singh, SK, Vishwas, S, Adams, J, Hansbro, PM, Oliver, B, Gupta, G, Dureja, H & Dua, K 2024, 'Plant-based therapeutics for chronic obstructive pulmonary diseases: Nanoformulation strategies to overcome delivery challenges', Food Bioscience, vol. 58, pp. 103761-103761.
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Lean, I, Zadoks, R, Brito, B & Golder, H 2024, 'Milk as a diagnostic fluid', Australian Veterinary Journal, vol. 102, no. 1-2, pp. 3-4.
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Li, J, Gao, L, Pan, F, Gong, C, Sun, L, Gao, H, Zhang, J, Zhao, Y, Wang, G & Liu, H 2024, 'Engineering Strategies for Suppressing the Shuttle Effect in Lithium–Sulfur Batteries', Nano-Micro Letters, vol. 16, no. 1.
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AbstractLithium–sulfur (Li–S) batteries are supposed to be one of the most potential next-generation batteries owing to their high theoretical capacity and low cost. Nevertheless, the shuttle effect of firm multi-step two-electron reaction between sulfur and lithium in liquid electrolyte makes the capacity much smaller than the theoretical value. Many methods were proposed for inhibiting the shuttle effect of polysulfide, improving corresponding redox kinetics and enhancing the integral performance of Li–S batteries. Here, we will comprehensively and systematically summarize the strategies for inhibiting the shuttle effect from all components of Li–S batteries. First, the electrochemical principles/mechanism and origin of the shuttle effect are described in detail. Moreover, the efficient strategies, including boosting the sulfur conversion rate of sulfur, confining sulfur or lithium polysulfides (LPS) within cathode host, confining LPS in the shield layer, and preventing LPS from contacting the anode, will be discussed to suppress the shuttle effect. Then, recent advances in inhibition of shuttle effect in cathode, electrolyte, separator, and anode with the aforementioned strategies have been summarized to direct the further design of efficient materials for Li–S batteries. Finally, we present prospects for inhibition of the LPS shuttle and potential development directions in Li–S batteries.
Li, S, Wang, B, Liu, DL, Chen, C, Feng, P, Huang, M, Wang, X, Shi, L, Waters, C, Huete, A & Yu, Q 2024, 'Can agronomic options alleviate the risk of compound drought-heat events during the wheat flowering period in southeastern Australia?', European Journal of Agronomy, vol. 153, pp. 127030-127030.
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Liu, T, Zhang, W, Wang, L, Ueland, M, Forbes, SL, Zheng, WX & Su, SW 2024, 'Numerical Differentiation From Noisy Signals: A Kernel Regularization Method to Improve Transient-State Features for the Electronic Nose', IEEE Transactions on Systems, Man, and Cybernetics: Systems, pp. 1-15.
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Liu, Z, Sun, B, Zhang, Y, Zhang, Q & Fan, L 2024, 'Polymer-adjusted zinc anode towards high-performance aqueous zinc ion batteries', Progress in Polymer Science, vol. 152, pp. 101817-101817.
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Luong, HA, Rohlfs, A-M, Facey, JA, Colville, A & Mitrovic, SM 2024, 'Long-term study of phytoplankton dynamics in a supply reservoir reveals signs of trophic state shift linked to changes in hydrodynamics associated with flow management and extreme events', Water Research, vol. 256, pp. 121547-121547.
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Mahmodi, H, Poulton, CG, Leslie, MN, Oldham, G, Ong, HX, Langford, SJ & Kabakova, IV 2024, 'Principal component analysis in application to Brillouin microscopy data', Journal of Physics: Photonics, vol. 6, no. 2, pp. 025009-025009.
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Abstract Brillouin microscopy has recently emerged as a new bio-imaging modality that provides information on the microscale mechanical properties of biological materials, cells and tissues. The data collected in a typical Brillouin microscopy experiment represents the high-dimensional set of spectral information, i.e. each pixel within a 2D/3D Brillouin image is associated with hundreds of points of spectral data. Its analysis requires non-trivial approaches due to subtlety in spectral variations as well as spatial and spectral overlaps of measured features. This article offers a guide to the application of Principal Component Analysis (PCA) for processing Brillouin imaging data. Being unsupervised multivariate analysis, PCA is well-suited to tackle processing of complex Brillouin spectra from heterogeneous biological samples with minimal a priori information requirements. We point out the importance of data pre-processing steps in order to improve outcomes of PCA. We also present a strategy where PCA combined with k-means clustering method can provide a working solution to data reconstruction and deeper insights into sample composition, structure and mechanics.
Mahmood, A, Zheng, Z & Chen, Y 2024, 'Zinc–Bromine Batteries: Challenges, Prospective Solutions, and Future', Advanced Science, vol. 11, no. 3, p. e2305561.
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AbstractZinc‐bromine batteries (ZBBs) have recently gained significant attention as inexpensive and safer alternatives to potentially flammable lithium‐ion batteries. Zn metal is relatively stable in aqueous electrolytes, making ZBBs safer and easier to handle. However, Zn metal anodes are still affected by several issues, including dendrite growth, Zn dissolution, and the crossover of Br species from cathodes to corrode anodes, resulting in self‐discharge and fast performance fading. Similarly, Br2 undergoes sluggish redox reactions on cathodes, which brings several issues such as poor reaction kinetics, the highly corrosive nature of Br species leading to corrosion of separators and poisoning of anodes, and the volatile nature of Br species causing increased internal pressures, etc. These issues are compounded in flowless ZBB configuration as no fresh electrolyte is available to provide extra/fresh reaction species. In this review, the factors controlling the performance of ZBBs in flow and flowless configurations are thoroughly reviewed, along with the status of ZBBs in the commercial sector. The review also summarizes various novel methodologies to mitigate these challenges and presents research areas for future studies. In summary, this review will offer a perspective on the historical evolution, recent advancements, and prospects of ZBBs.
Mai, TNA, Ali, S, Hossain, MS, Chen, C, Ding, L, Chen, Y, Solntsev, AS, Mou, H, Xu, X, Medhekar, N & Tran, TT 2024, 'Cryogenic Thermal Shock Effects on Optical Properties of Quantum Emitters in Hexagonal Boron Nitride', ACS Applied Materials & Interfaces, vol. 16, no. 15, pp. 19340-19349.
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Solid-state quantum emitters are vital building blocks for quantum information science and quantum technology. Among various types of solid-state emitters discovered to date, color centers in hexagonal boron nitride have garnered tremendous traction in recent years, thanks to their environmental robustness, high brightness, and room-temperature operation. Most recently, these quantum emitters have been employed for satellite-based quantum key distribution. One of the most important requirements to qualify these emitters for space-based applications is their optical stability against cryogenic thermal shock. Such an understanding has, however, remained elusive to date. Here, we report on the effects caused by such thermal shock that induces random, irreversible changes in the spectral characteristics of the quantum emitters. By employing a combination of structural characterizations and density functional calculations, we attribute the observed changes to lattice strain caused by cryogenic temperature shock. Our study sheds light on the stability of the quantum emitters under extreme conditions─similar to those countered in outer space.
Mamun, SMN, Kumar Paul, D, Matar, F, Ton-That, C & Rahman, MA 2024, 'Zinc Dopant-Induced Modulation of Electronic Structure and Defect Emissions in Monoclinic Gallium Oxide', The Journal of Physical Chemistry C, vol. 128, no. 11, pp. 4722-4728.
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Manandhar, B, Paudel, KR, Clarence, DD, De Rubis, G, Madheswaran, T, Panneerselvam, J, Zacconi, FC, Williams, KA, Pont, LG, Warkiani, ME, MacLoughlin, R, Oliver, BG, Gupta, G, Singh, SK, Chellappan, DK, Hansbro, PM & Dua, K 2024, 'Zerumbone-incorporated liquid crystalline nanoparticles inhibit proliferation and migration of non-small-cell lung cancer in vitro', Naunyn-Schmiedeberg's Archives of Pharmacology, vol. 397, no. 1, pp. 343-356.
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AbstractLung cancer is the second most prevalent type of cancer and is responsible for the highest number of cancer-related deaths worldwide. Non-small-cell lung cancer (NSCLC) makes up the majority of lung cancer cases. Zerumbone (ZER) is natural compound commonly found in the roots of Zingiber zerumbet which has recently demonstrated anti-cancer activity in both in vitro and in vivo studies. Despite their medical benefits, ZER has low aqueous solubility, poor GI absorption and oral bioavailability that hinders its effectiveness. Liquid crystalline nanoparticles (LCNs) are novel drug delivery carrier that have tuneable characteristics to enhance and ease the delivery of bioactive compounds. This study aimed to formulate ZER-loaded LCNs and investigate their effectiveness against NSCLC in vitro using A549 lung cancer cells. ZER-LCNs, prepared in the study, inhibited the proliferation and migration of A549 cells. These inhibitory effects were superior to the effects of ZER alone at a concentration 10 times lower than that of free ZER, demonstrating a potent anti-cancer activity of ZER-LCNs. The underlying mechanisms of the anti-cancer effects by ZER-LCNs were associated with the transcriptional regulation of tumor suppressor genes P53 and PTEN, and metastasis-associated gene KRT18. The protein array data showed downregulation of several proliferation associated proteins such as AXL, HER1, PGRN, and BIRC5 and metastasis-associated proteins such as DKK1, CAPG, CTSS, CTSB, CTSD, and PLAU. This study provides evidence of potential for increasing the potency and effectiveness of ZER with LCN formulation and developing ZER-LCNs as a treatment strategy for mitigation and treatment of NSCLC.
McKnight, DJE, Wong-Bajracharya, J, Okoh, EB, Snijders, F, Lidbetter, F, Webster, J, Haughton, M, Darling, AE, Djordjevic, SP, Bogema, DR & Chapman, TA 2024, 'Xanthomonas rydalmerensis sp. nov., a non-pathogenic member of Group 1 Xanthomonas', International Journal of Systematic and Evolutionary Microbiology, vol. 74, no. 3.
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Five bacterial isolates were isolated from Fragaria × ananassa in 1976 in Rydalmere, Australia, during routine biosecurity surveillance. Initially, the results of biochemical characterisation indicated that these isolates represented members of the genus Xanthomonas. To determine their species, further analysis was conducted using both phenotypic and genotypic approaches. Phenotypic analysis involved using MALDI-TOF MS and BIOLOG GEN III microplates, which confirmed that the isolates represented members of the genus Xanthomonas but did not allow them to be classified with respect to species. Genome relatedness indices and the results of extensive phylogenetic analysis confirmed that the isolates were members of the genus Xanthomonas and represented a novel species. On the basis the minimal presence of virulence-associated factors typically found in genomes of members of the genus Xanthomonas, we suggest that these isolates are non-pathogenic. This conclusion was supported by the results of a pathogenicity assay. On the basis of these findings, we propose the name Xanthomonas rydalmerensis, with DAR 34855T = ICMP 24941 as the type strain.
Mediati, DG, Dan, W, Lalaouna, D, Dinh, H, Pokhrel, A, Rowell, KN, Michie, KA, Stinear, TP, Cain, AK & Tree, JJ 2024, 'The 3′ UTR of vigR is required for virulence in Staphylococcus aureus and has expanded through STAR sequence repeat insertions', Cell Reports, vol. 43, no. 4, pp. 114082-114082.
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Mills, J, Gebhard, LJ, Schubotz, F, Shevchenko, A, Speth, DR, Liao, Y, Duggin, IG, Marchfelder, A & Erdmann, S 2024, 'Extracellular vesicle formation in Euryarchaeota is driven by a small GTPase', Proceedings of the National Academy of Sciences, vol. 121, no. 10.
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Since their discovery, extracellular vesicles (EVs) have changed our view on how organisms interact with their extracellular world. EVs are able to traffic a diverse array of molecules across different species and even domains, facilitating numerous functions. In this study, we investigate EV production in Euryarchaeota, using the model organism Haloferax volcanii . We uncover that EVs enclose RNA, with specific transcripts preferentially enriched, including those with regulatory potential, and conclude that EVs can act as an RNA communication system between haloarchaea. We demonstrate the key role of an EV-associated small GTPase for EV formation in H. volcanii that is also present across other diverse evolutionary branches of Archaea. We propose the name, ArvA, for the identified family of archaeal vesiculating GTPases. Additionally, we show that two genes in the same operon with arvA ( arvB and arvC ) are also involved in EV formation. Both, arvB and arvC , are closely associated with arvA in the majority of other archaea encoding ArvA. Our work demonstrates that small GTPases involved in membrane deformation and vesiculation, ubiquitous in Eukaryotes, are also present in Archaea and are widely distributed across diverse archaeal phyla.
Missen, OP, Mills, SJ, Thaise Moro, T, Villalobos-Portillo, EE, Castillo-Michel, H, Lockwood, TE, Gonzalez de Vega, R & Clases, D 2024, 'Natural cobalt–manganese oxide nanoparticles: speciation, detection and implications for cobalt cycling', Environmental Chemistry, vol. 21, no. 2.
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Naeem, U, Zahra, SA, Ali, I, Li, H, Mahmood, A & Rizwan, S 2024, 'Unleashing the potential of NiO@V2CTx MXene-derived electrocatalyst for hydrogen and oxygen evolution', International Journal of Hydrogen Energy, vol. 59, pp. 635-644.
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Neuteboom, W, Ross, A, Bugeja, L, Willis, S, Roux, C & Lothridge, K 2024, 'Quality Management in forensic science: A closer inspection', Forensic Science International, vol. 358, pp. 111779-111779.
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Panthi, VK, Bashyal, S & Paudel, KR 2024, 'Docetaxel-loaded nanoformulations delivery for breast cancer management: Challenges, recent advances, and future perspectives', Journal of Drug Delivery Science and Technology, vol. 92, pp. 105314-105314.
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Parker, LM, Scanes, E, O'Connor, WA, Dove, M, Elizur, A, Pörtner, H-O & Ross, PM 2024, 'Resilience against the impacts of climate change in an ecologically and economically significant native oyster', Marine Pollution Bulletin, vol. 198, pp. 115788-115788.
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Passarelli, N, Palomba, S, Kabakova, I & de Sterke, CM 2024, 'Rational design of an integrated directional coupler for wideband operation', Applied Optics, vol. 63, no. 14, pp. D28-D28.
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We consider a design procedure for directional couplers for which the coupling length is approximately wavelength-independent over a wide bandwidth. We show analytically that two coupled planar waveguides exhibit a maximum in the coupling strength, which ensures both wideband transmission and minimal device footprint. This acts as a starting point for mapping out the relevant part of phase space. This analysis is then generalized to the fully three-dimensional geometry of rib waveguides using an effective medium approximation. This forms an excellent starting point for fully numerical calculations and leads to designs with unprecedented bandwidths and compactness.
Paudel, KR, Clarence, DD, Panth, N, Manandhar, B, De Rubis, G, Devkota, HP, Gupta, G, Zacconi, FC, Williams, KA, Pont, LG, Singh, SK, Warkiani, ME, Adams, J, MacLoughlin, R, Oliver, BG, Chellappan, DK, Hansbro, PM & Dua, K 2024, 'Zerumbone liquid crystalline nanoparticles protect against oxidative stress, inflammation and senescence induced by cigarette smoke extract in vitro', Naunyn-Schmiedeberg's Archives of Pharmacology, vol. 397, no. 4, pp. 2465-2483.
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AbstractThe purpose of this study was to evaluate the potential of zerumbone-loaded liquid crystalline nanoparticles (ZER-LCNs) in the protection of broncho-epithelial cells and alveolar macrophages against oxidative stress, inflammation and senescence induced by cigarette smoke extract in vitro. The effect of the treatment of ZER-LCNs on in vitro cell models of cigarette smoke extract (CSE)-treated mouse RAW264.7 and human BCi-NS1.1 basal epithelial cell lines was evaluated for their anti-inflammatory, antioxidant and anti-senescence activities using colorimetric and fluorescence-based assays, fluorescence imaging, RT-qPCR and proteome profiler kit. The ZER-LCNs successfully reduced the expression of pro-inflammatory markers including Il-6, Il-1β and Tnf-α, as well as the production of nitric oxide in RAW 264.7 cells. Additionally, ZER-LCNs successfully inhibited oxidative stress through reduction of reactive oxygen species (ROS) levels and regulation of genes, namely GPX2 and GCLC in BCi-NS1.1 cells. Anti-senescence activity of ZER-LCNs was also observed in BCi-NS1.1 cells, with significant reductions in the expression of SIRT1, CDKN1A and CDKN2A. This study demonstrates strong in vitro anti-inflammatory, antioxidative and anti-senescence activities of ZER-LCNs paving the path for this formulation to be translated into a promising therapeutic agent for chronic respiratory inflammatory conditions including COPD and asthma.
Paudel, KR, Mohamad, MSB, De Rubis, G, Reyes, R-J, Panth, N, Dureja, H, Gupta, G, Singh, SK, Madheswaran, T, Collet, T, Hansbro, PM, Dua, K & Chellappan, DK 2024, '18-β-Glycyrrhetinic acid encapsulated PLGA nanoparticles attenuate lung cancer proliferation and migration', Journal of Drug Delivery Science and Technology, vol. 95, pp. 105523-105523.
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Perveen, S, Padula, MP, Safdar, N & Abbas, S 2024, 'Functional annotation of proteins in Catharanthus roseus shoot cultures under biogenic zinc nanotreatment', Plant Molecular Biology, vol. 114, no. 2.
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Pham, NHT, Joglekar, MV, Wong, WKM, Nassif, NT, Simpson, AM & Hardikar, AA 2024, 'Short-chain fatty acids and insulin sensitivity: a systematic review and meta-analysis', Nutrition Reviews, vol. 82, no. 2, pp. 193-209.
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Abstract Context There is substantial evidence that reduced short-chain fatty acids (SCFAs) in the gut are associated with obesity and type 2 diabetes, although findings from clinical interventions that can increase SCFAs are inconsistent. Objective This systematic review and meta-analysis aimed to assess the effect of SCFA interventions on fasting glucose, fasting insulin, and homeostatic model assessment of insulin resistance (HOMA-IR). Data Sources Relevant articles published up to July 28, 2022, were extracted from PubMed and Embase using the MeSH (Medical Subject Headings) terms of the defined keywords [(short-chain fatty acids) AND (obesity OR diabetes OR insulin sensitivity)] and their synonyms. Data analyses were performed independently by two researchers who used the Cochrane meta-analysis checklist and the PRISMA guidelines. Data Extraction Clinical studies and trials that measured SCFAs and reported glucose homeostasis parameters were included in the analysis. Standardized mean differences (SMDs) with 95%CIs were calculated using a random-effects model in the data extraction tool Review Manager version 5.4 (RevMan 5.4). The risk-of-bias assessment was performed following the Cochrane checklist for randomized and crossover studies. Data Analysis In total, 6040 nonduplicate studies were identified, 23 of which me...
Picci, G, Montis, R, Gilchrist, AM, Gale, PA & Caltagirone, C 2024, 'Fluorescent and colorimetric sensors for anions: Highlights from 2020 to 2022', Coordination Chemistry Reviews, vol. 501, pp. 215561-215561.
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Pierce, JE, OHalloran, R, Togher, L, Nickels, L, Copland, D, Godecke, E, Meinzer, M, Rai, T, Cadilhac, DA, Kim, J, Hurley, M, Foster, A, Carragher, M, Wilcox, C, Steel, G & Rose, ML 2024, 'Acceptability, feasibility and preliminary efficacy of low-moderate intensity Constraint Induced Aphasia Therapy and Multi-Modality Aphasia Therapy in chronic aphasia after stroke', Topics in Stroke Rehabilitation, vol. 31, no. 1, pp. 44-56.
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Qashlan, A, Nanda, P & Mohanty, M 2024, 'Differential privacy model for blockchain based smart home architecture', Future Generation Computer Systems, vol. 150, pp. 49-63.
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Qian, C, Zhou, Y, Zhang, T, Dong, G, Song, M, Tang, Y, Wei, Z, Yu, S, Shen, Q, Chen, W, Choi, JP, Yan, J, Zhong, C, Wan, L, Li, J, Wang, A, Lu, Y & Zhao, Y 2024, 'Targeting PKM2 signaling cascade with salvianic acid A normalizes tumor blood vessels to facilitate chemotherapeutic drug delivery', Acta Pharmaceutica Sinica B.
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REDMOND, G, MAIN, G, O’DONNELL, AW, SKATTEBOL, J, WOODMAN, R, MOONEY, A, WANG, J, TURKMANI, S, THOMSON, C & BROOKS, F 2024, 'Who excludes? Young People’s Experience of Social Exclusion', Journal of Social Policy, vol. 53, no. 1, pp. 236-259.
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AbstractExisting policy research has not comprehensively examined the processes by which young people experience social exclusion: that is, the relationships among different risk factors for exclusion, their actual experiences of exclusion, and outcomes that matter for their life chances. Drawing on data from a survey of Australian 13-14 year olds (N=3,535), this paper adapts the Bristol Social Exclusion Matrix to examine pathways from young people’s personal and family resources, their experience of participation (school engagement; bullying victimization; teacher support), and their life satisfaction – a predictive indicator of wellbeing and mental health in adulthood. The effects of other characteristics or risk factors for young people’s social exclusion (living with disability, being a young carer, identifying as Indigenous, and speaking a language other than English at home), are also examined. This paper shows that experience of exclusion mediates the relationship between young people’s personal and family resources and life satisfaction. Controlling for characteristics or risk factors does not change this relationship, suggesting that processes of social exclusion, enacted in interpersonal encounters, are driven by overarching structural factors. These findings are relevant for policy in Australia, and in other countries with similar policy regimes.
Rennie, C, Sives, C, Boyton, I, Diaz, D, Gorrie, C, Vittorio, O, Collins‐Praino, L & Care, A 2024, 'In Vivo Behavior of Systemically Administered Encapsulin Protein Nanocages and Implications for their use in Targeted Drug Delivery', Advanced Therapeutics, vol. 7, no. 2.
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AbstractEncapsulins, self‐assembling protein nanocages derived from prokaryotes, are promising nanoparticle‐based drug delivery systems (NDDS). However, the in vivo behavior and fate of encapsulins are poorly understood. In this study, the interactions between the model encapsulin from Thermotoga maritima (TmEnc) and key biological barriers encountered by NDDS are probed. Here, a purified TmEnc formulation that exhibits colloidal stability, storability, and blood compatibility is intravenously injected into BALB/c mice. TmEnc has an excellent nanosafety profile, with no abnormal weight loss or gross pathology observed, and only temporary alterations in toxicity biomarkers are detected. Notably, TmEnc demonstrates immunogenic properties, inducing the generation of nanocage‐specific IgM and IgG antibodies, but without any prolonged pro‐inflammatory effects. An absence of antibody cross‐reactivity also suggests immune‐orthogonality among encapsulin systems. Moreover, TmEnc forms a serum‐derived protein corona on its surface which changes dynamically and appears to play a role in immune recognition. TmEnc's biodistribution profile further reveals its sequestration from the blood circulation by the liver and then biodegrades within Kupffer cells, thus indicating clearance via the mononuclear phagocyte system. Collectively, these findings provide critical insights into how encapsulins behave in vivo, thereby informing their future design, modification, and application in targeted drug delivery.
Rennie, C, Sives, C, Boyton, I, Diaz, D, Gorrie, C, Vittorio, O, Collins‐Praino, L & Care, A 2024, 'In Vivo Behavior of Systemically Administered Encapsulin Protein Nanocages and Implications for their use in Targeted Drug Delivery (Adv. Therap. 2/2024)', Advanced Therapeutics, vol. 7, no. 2.
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Rigg, AL, Bellotto, C, Fowler, AM & Booth, DJ 2024, 'Staining protocols affect use of otolith to estimate the demography of the damselfish sergeant major (Abudefduf vaigiensis)', Journal of Fish Biology, vol. 104, no. 3, pp. 878-882.
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AbstractThis study assessed the otolith (sagittae, lapilli, and asterisci) increment deposition rate in the range‐shifting damselfish, A. vaigiensis, using different concentrations of Alizain Red S and evaluated the impact of staining on increment width. Daily increment deposition was verified in all otolith types and presented clearer fluorescent markings in the lapilli and sagittae than the asterisci, with high stain concentration showing the best clarity. Higher stain concentrations were found to decrease increment width, suggesting care is needed when using stained otoliths as a proxy for growth for this species.
Ritchie, RJ, Sma-Air, S, Johnson, MS, Murray, SA, Nguyen, A, Larkum, AWD & Dummee, V 2024, 'Photosynthesis in a green alga (zoochlorella), Chlorella cf. vulgaris in the soft coral Sarcophyton sp.', Phycologia, vol. 63, no. 1, pp. 60-73.
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Roy Chowdhury, P, Alhamami, T, Venter, H, Veltman, T, Carr, M, Mollinger, J, Trott, DJ & Djordjevic, SP 2024, 'Identification and evolution of ICE-PmuST394: a novel integrative conjugative element in Pasteurella multocida ST394', Journal of Antimicrobial Chemotherapy, vol. 79, no. 4, pp. 851-858.
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Abstract Background The emergence of macrolide and tetracycline resistance within Pasteurella multocida isolated from feedlot cattle and the dominance of ST394 in Australia was reported recently. Objectives To establish the genetic context of the resistance genes in P. multocida 17BRD-035, the ST394 reference genome, and conduct a molecular risk assessment of their ability to disperse laterally. Methods A bioinformatic analysis of the P. multocida 17BRD-035 genome was conducted to determine if integrative conjugative elements (ICEs) carrying resistance genes, which hamper antibiotic treatment options locally, are in circulation in Australian feedlots. Results A novel element, ICE-PmuST394, was characterized in P. multocida 17BRD-035. It was also identified in three other isolates (two ST394s and a ST125) in Australia and is likely present in a genome representing P. multocida ST79 from the USA. ICE-PmuST394 houses a resistance module carrying two variants of the blaROB gene, blaROB-1 and blaROB-13, and the macrolide esterase gene, estT. The resistance gene combination on ICE-PmuST394 confers resistance to ampicillin and tilmicosin, but not to tulathromycin and tildipirosin. Our analysis suggests that ICE-PmuST394 is circulating both by clonal expansion and horizontal transfer but is currently restricted to a single feedlot in Australia. Conclusions
Roy, R, York, E, Pacchini, E & Rawling, T 2024, 'Effects of cationic head group structure on cytotoxicity and mitochondrial actions of amphiphilic ionic liquids', Food and Chemical Toxicology, vol. 183, pp. 114202-114202.
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Ionic liquids (ILs) are a class of low melting point salts with physicochemical properties that make them suitable for a range of industrial applications. Accumulating evidence suggests that certain ILs are cytotoxic and potential environmental pollutants, thus understanding the structural features that promote IL cytotoxicity is important. Amphiphilic ionic liquids (AmILs), a class of ILs with lipophilic N-alkyl chains, containing aromatic head groups are generally more cytotoxic than their aliphatic counterparts, however the impact of other head group properties are less clear. This study therefore sought to provide new structure activity relationship (SAR) insights regarding the role of the cationic head group on AmIL cytotoxicity. A series of AmILs bearing a range of structurally diverse aromatic cations varying in size, charge, and lipophilicity was synthesised and screened against human MDA-MB-231 breast cancer cells. It was found that larger and more lipophilic head groups increased cytotoxicity, although the magnitude of the changes were modest. The mitochondrial effects of representative ILs were assessed. The AmILs induced mitochondrial dysfunction in MDA-MB-231 cells at cytotoxic concentrations, suggesting that they target mitochondria. The new SAR information from this study may assist in the design of AmILs with controlled cytotoxicity.
Saeid, AB, De Rubis, G, Williams, KA, Yeung, S, Chellappan, DK, Singh, SK, Gupta, G, Hansbro, PM, Shahbazi, M-A, Gulati, M, Kaur, IP, Santos, HA, Paudel, KR & Dua, K 2024, 'Revolutionising Lung Health: Exploring the Latest Breakthroughs and Future Prospects of Synbiotic Nanostructures in Lung Diseases', Chemico-Biological Interactions, pp. 111009-111009.
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Salih, AK, Aditya, L, Matar, F, Nghiem, LD & Ton-That, C 2024, 'Improved flux and anti-fouling performance of a photocatalytic ZnO membrane on porous stainless steel substrate for microalgae harvesting', Journal of Membrane Science, vol. 694, pp. 122405-122405.
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Sasaki, M, Mitchell, A, Booth, DJ & Nagelkerken, I 2024, 'Novel ecological interactions alter physiological responses of range-extending tropical and local temperate fishes under ocean warming', Science of The Total Environment, vol. 913, pp. 169413-169413.
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Scanes, E, Kutti, T, Fang, JKH, Johnston, EL, Ross, PM & Bannister, RJ 2024, 'The long-lived deep-sea bivalve Acesta excavata is sensitive to the dual stressors of sediment and warming', Marine Pollution Bulletin, vol. 202, pp. 116323-116323.
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Seymour, JR, Brumley, DR, Stocker, R & Raina, J-B 2024, 'Swimming towards each other: the role of chemotaxis in bacterial interactions', Trends in Microbiology.
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Siboni, N, King, WL, Williams, NLR, Scanes, E, Giardina, M, Green, TJ, Ostrowski, M, O'Connor, W, Dove, M, Labbate, M & Seymour, JR 2024, 'Increased abundance of potentially pathogenic Vibrio and a marine heatwave co-occur with a Pacific Oyster summer mortality event', Aquaculture, vol. 583, pp. 740618-740618.
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Siddique, MAB, Imran, M, Haider, A, Shahzadi, A, Ul-Hamid, A, Nabgan, W, Batool, M, Khan, K, Ikram, M, Somaily, HH & Mahmood, A 2024, 'Enhancing catalytic and antibacterial activity with size-controlled yttrium and graphene quantum dots doped MgO nanostructures: A molecular docking analysis', Materials Today Sustainability, vol. 25, pp. 100690-100690.
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Singh, M, De Rubis, G, Kokkinis, S, Paudel, KR, Yeung, S, Hansbro, PM, Oliver, BGG & Dua, K 2024, 'Curcumin-Loaded Liposomes modulating the synergistic role of EpCAM and Estrogen Receptor Alpha in Lung Cancer Management', Pathology - Research and Practice, pp. 155317-155317.
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Singh, S, Saxena, S, Sharma, H, Paudel, KR, Chakraborty, A, MacLoughlin, R, Oliver, BG, Gupta, G, Negi, P, Singh, SK & Dua, K 2024, 'Emerging role of tumor suppressing microRNAs as therapeutics in managing non-small cell lung cancer', Pathology - Research and Practice, vol. 256, pp. 155222-155222.
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Sofian, M, Nasim, F, Ali, H, Kanodarwala, FK & Nadeem, MA 2024, 'Efficient formic acid oxidation over gallium oxide incorporated Pd containing electrocatalyst', International Journal of Hydrogen Energy, vol. 51, pp. 1277-1285.
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Solanki, N, Gupta, G, Chellappan, DK, Singh, SK, Gulati, M, Paudel, KR, Hansbro, PM, Dua, K, Bhan, S, Saini, M & Dureja, H 2024, 'Boswellic Acids: A Critical Appraisal of Their Therapeutic and Nutritional Benefits in Chronic Inflammatory Diseases', Endocrine, Metabolic & Immune Disorders - Drug Targets, vol. 24, no. 1, pp. 116-129.
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Background:In the last few decades, it has been largely perceived that the factors affecting the immune system and its varying pathways lead to the pathological progression of inflammation and inflammatory conditions. Chronic inflammation also contributes to common diseases, such as diabetes mellitus, ischemic heart disease, cancer, chronic renal inflammatory disease, non-alcoholic fatty hepat-ic disease, autoimmune diseases and neurodegenerative diseases.Objective:Interestingly, plant sources and secondary metabolites from plants have been increasingly employed in managing acute and chronic inflammatory diseases for centuries. Boswellic acids are pentacyclic triterpenoidal moieties obtained from the oleo gum resin of different Boswellia species.Methods:Detailed data was collected revealing the anti-inflammatory potential of Boswellic acids through various databases.Results:These are pharmacologically active agents that possess promising anti-inflammatory, anti-arthritic, antirheumatic, anti-diarrheal, anti-hyperlipidemic, anti-asthmatic, anti-cancer, and anti-microbial effects.Conclusion:Boswellic acids have been in use since ancient times primarily to treat acute and chronic inflammatory diseases. This review discusses the various mechanisms underlying the inflammatory process and the necessity of such natural products as a medication to treat inflammatory diseases. In addition, a discussion has also been extended to understand the primary targets involved in inflamma-tion. The review further explores the therapeutic potential of boswellic acids in
Strudwick, P, Camp, EF, Seymour, J, Roper, C, Edmondson, J, Howlett, L & Suggett, DJ 2024, 'Impacts of plastic‐free materials on coral‐associated bacterial communities during reef restoration', Environmental Microbiology Reports, vol. 16, no. 1.
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AbstractCoral propagation and out‐planting based restoration approaches are increasingly being applied to assist natural recovery of coral reefs. However, many restoration methods rely on plastic zip‐ties to secure coral material which is potentially problematic for the marine environment. Plastic‐free biodegradable alternatives may however pose unique risks to coral‐associated bacterial communities integral to coral health. Therefore, to identify whether biodegradable materials differentially impact coral‐associated bacterial communities we examined Acropora millepora coral‐associated bacterial communities during propagation in two experiments on the Great Barrier Reef. Coral fragments were secured to coral nurseries with conventional plastic, metal, or biodegradable (polyester and polycaprolactone) ties. Tie failure and coral‐associated bacterial communities were then characterized over six months. Minimal coral mortality was observed (3.6%–8%) and all ties had low failure rates (0%–4.2%) except for biodegradable polyester ties (29.2% failure). No differences were observed between coral‐associated bacterial communities of fragments secured with different ties, and no proliferation of putatively pathogenic bacteria was recorded. Overall, our findings suggest that reducing reliance on conventional plastic is feasible through transitions to biodegradable materials, without any notable impacts on coral‐associated bacterial communities. However, we caution the need to examine more coral taxa of different morphologies and new plastic‐free materials prior to application.
Stuart, B, Frankham, GJ, Mangion, G & Ueland, M 2024, 'A rapid and non-destructive identification method for tortoiseshell products using attenuated total reflectance infrared spectroscopy', Forensic Science International: Animals and Environments, vol. 5, pp. 100079-100079.
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Stuart, B, Guan, J, Collins, S, Thomas, P & Ueland, M 2024, 'A preliminary study of non-woven fabrics for forensic identification purposes', Australian Journal of Forensic Sciences, vol. 56, no. 2, pp. 144-153.
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While traditional woven textiles have been the subject of many forensic investigations, non-woven fabrics have received minimal attention thus far. Given the expansion of commercial applications of non-woven fabrics, a preliminary investigation of household wipes has been carried out to characterize the compositions of these widely available non-woven fabrics. Infrared spectroscopy and thermogravimetric analysis were employed to identify the fibre type and additives of three types of commercial wipes. Polyester and/or viscose fibres were found to be the main components and, along with the identification of binders, enable source types to be differentiated. The predicted different sensitivities of the fibre types to biodeterioration highlights the importance of future environmental studies for the correct characterization of non-woven fabrics in evidence.
Stylianou, N, Sebina, I, Matigian, N, Monkman, J, Doehler, H, Röhl, J, Allenby, M, Nam, A, Pan, L, Rockstroh, A, Sadeghirad, H, Chung, K, Sobanski, T, O'Byrne, K, Almeida, ACSF, Rebutini, PZ, Machado‐Souza, C, Stonoga, ETS, Warkiani, ME, Salomon, C, Short, K, McClements, L, de Noronha, L, Huang, R, Belz, GT, Souza‐Fonseca‐Guimaraes, F, Clifton, V & Kulasinghe, A 2024, 'Whole transcriptome profiling of placental pathobiology in SARS‐CoV‐2 pregnancies identifies placental dysfunction signatures', Clinical & Translational Immunology, vol. 13, no. 2.
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AbstractObjectivesSevere Acute Respiratory Syndrome Coronavirus 2 (SARS‐CoV‐2) virus infection in pregnancy is associated with higher incidence of placental dysfunction, referred to by a few studies as a ‘preeclampsia‐like syndrome’. However, the mechanisms underpinning SARS‐CoV‐2‐induced placental malfunction are still unclear. Here, we investigated whether the transcriptional architecture of the placenta is altered in response to SARS‐CoV‐2 infection.MethodsWe utilised whole‐transcriptome, digital spatial profiling, to examine gene expression patterns in placental tissues from participants who contracted SARS‐CoV‐2 in the third trimester of their pregnancy (n = 7) and those collected prior to the start of the coronavirus disease 2019 (COVID‐19) pandemic (n = 9).ResultsThrough comprehensive spatial transcriptomic analyses of the trophoblast and villous core stromal cell subpopulations in the placenta, we identified SARS‐CoV‐2 to promote signatures associated with hypoxia and placental dysfunction. Notably, genes associated with vasodilation (NOS3), oxidative stress (GDF15, CRH) and preeclampsia (FLT1, EGFR, KISS1, PAPPA2) were enriched with SARS‐CoV‐2. Pathways related to increased nutrient uptake, vascular tension, hypertension and inflammation were also enriched in SARS‐CoV‐2 samples compared to uninfected controls.ConclusionsOur findings demonstrate the utility of spatially resolved transcriptomic analysis in defining the underlying pathogenic mechanisms of S...
Su, F, Chen, S, Liu, Y, Zhou, J, Du, Z, Luo, X, Wen, S & Jin, D 2024, 'Lanthanide Complex for Single-Molecule Fluorescent in Situ Hybridization and Background-Free Imaging', Analytical Chemistry, vol. 96, no. 11, pp. 4430-4436.
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Sullivan, E, Zeki, R, Ward, S, Sherwood, J, Remond, M, Chang, S, Kypri, K & Brown, J 2024, 'Effects of the Connections program on return‐to‐custody, mortality and treatment uptake among people with a history of opioid use: Retrospective cohort study in an Australian prison system', Addiction, vol. 119, no. 1, pp. 169-179.
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AbstractBackground and AimsConnections is a voluntary health program that facilitates access to opioid agonist treatment (OAT) and social services for people with opioid use exiting prison. This study aimed to measure the effectiveness of Connections in reducing recidivism and improving health outcomes for people with a history of opioid use on leaving prison.DesignRetrospective cohort study with quasi‐random allocation to the program.SettingPublic adult prisons in New South Wales, Australia, 2008–2015.ParticipantsAdults released from custody with a history of opioid use. Of 5549 eligible releasees, 3973 were allocated to Connections and 1576 to treatment‐as‐usual.MeasurementsOutcomes were return‐to‐custody, all‐cause mortality, and OAT participation.FindingsRegression analyses on an intention‐to‐treat basis, and adjusting for baseline propensity scores, comparing patients allocated to Connections versus treatment‐as‐usual showed no difference in rates of return‐to‐custody within 2 years (hazard ratio [HR]: 1.01; 95% confidence interval [CI]: 0.92 –1.12). Patients allocated to the Connections program were more likely to access OAT (odds ratio [OR]: 1.21; 95% CI: 1.06–1.39) and had lower mortality within 28 days of release (0.25% vs. 0.66%; HR: 0.38; 95% CI: 0.14–1.03). Differences in mortality did not persist beyond 28 days. Subgroup analyses showed that allocation to Connections was associated with higher risk of return‐to‐custody within 28 days for Aboriginal and/or Torres Strait Islander (Indigenous) and female releasees.Conclusions<...
Thurn, B, Schotsmans, EMJ & Ueland, M 2024, 'Lime and odour: A preliminary investigation into the effect of hydrated lime on the volatiles emitted from human remains', Forensic Science International, vol. 358, pp. 111745-111745.
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Tobin, LA, Jarocki, VM, Kenyon, J, Drigo, B, Donner, E, Djordjevic, SP & Hamidian, M 2024, 'Genomic analysis of diverse environmental Acinetobacter isolates identifies plasmids, antibiotic resistance genes, and capsular polysaccharides shared with clinical strains', Applied and Environmental Microbiology, vol. 90, no. 2.
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ABSTRACT Acinetobacter baumannii, an important pathogen known for its widespread antibiotic resistance, has been the focus of extensive research within its genus, primarily involving clinical isolates. Consequently, data on environmental A. baumannii and other Acinetobacter species remain limited. Here, we utilized Illumina and Nanopore sequencing to analyze the genomes of 10 Acinetobacter isolates representing 6 different species sourced from aquatic environments in South Australia. All 10 isolates were phylogenetically distinct compared to clinical and other non-clinical Acinetobacter strains, often tens of thousands of single-nucleotide polymorphisms from their nearest neighbors. Despite the genetic divergence, we identified p dif modules (sections of mobilized DNA) carrying clinically important antimicrobial resistance genes in species other than A. baumannii , including carbapenemase oxa58, tetracycline resistance gene tet(39 ), and macrolide resistance genes msr(E)-mph(E ). These p dif modules were located on plasmids with high sequence identity to those circulating in globally distributed A. baumannii ST1 and ST2 clones. The environmental A. baumannii i...
van den Berge, M & Faiz, A 2024, 'Blood Biomarkers of Emphysema: What Can They Really Tell Us?', American Journal of Respiratory and Critical Care Medicine, vol. 209, no. 3, pp. 235-237.
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Van Haeften, S, Campbell, BC, Milic, A, Addison-Smith, E, Al Kouba, J, Huete, A, Beggs, PJ & Davies, JM 2024, 'Environmental DNA analysis of airborne poaceae (grass) pollen reveals taxonomic diversity across seasons and climate zones', Environmental Research, vol. 247, pp. 117983-117983.
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Vo, PHN, Danaee, S, Hai, HTN, Huy, LN, Nguyen, TAH, Nguyen, HTM, Kuzhiumparambil, U, Kim, M, Nghiem, LD & Ralph, PJ 2024, 'Biomining for sustainable recovery of rare earth elements from mining waste: A comprehensive review', Science of The Total Environment, vol. 908, pp. 168210-168210.
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Vo, PHN, Ky Le, G, Huy, LN, Zheng, L, Chaiwong, C, Nguyen, NN, Nguyen, HTM, Ralph, PJ, Kuzhiumparambil, U, Danaee, S, Toft, S, Madsen, C, Kim, M, Fenstermacher, J, Hai, HTN, Duan, H & Tscharke, B 2024, 'Occurrence, spatiotemporal trends, fate, and treatment technologies for microplastics and organic contaminants in biosolids: A review', Journal of Hazardous Materials, vol. 466, pp. 133471-133471.
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Vo, PHN, Nguyen, TTP, Nguyen, HTM, Baulch, J, Dong, S, Nguyen, CV, Thai, PK & Nguyen, AV 2024, 'PFAS removal from landfill leachate by ozone foam fractionation: System optimization and adsorption quantification', Water Research, vol. 253, pp. 121300-121300.
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Wajahat, M, Kouzani, AZ, Khoo, SY & Mahmud, MAP 2024, 'Development of Triboelectric Nanogenerators Using Novel 3D Printed Polymer Materials', Advanced Engineering Materials, vol. 26, no. 3.
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Triboelectric nanogenerators (TENGs) are becoming attractive devices for harvesting mechanical energy. 3D printing (3DP) is a newly reported technique for the development of this device. This technique is not fully explored for the fabrication of triboelectric materials and compatible printing processes. Herein, three main 3DP techniques including powder‐based multijet fusion, resin‐based polyjet fusion, and filament‐based fused deposition modeling are utilized to investigate new sets of 3DP triboelectric materials. Mechanical to electrical conversion efficiency of 3D printed and commercially available negative and positive triboelectric materials are compared and investigated. Polyamide ‐12 (PA12), Veroclear, acrylonitrile‐styrene‐acrylate (ASA), copper‐coated polylactic acid (Cu‐PLA), polycarbonate (PC), and polyethylene terephthalate glycol (PETG) are fabricated using compatible 3D printing techniques. 3D‐printed PA12 is considered as a reference positive triboelectric layer. Meanwhile, 3D‐printed Veroclear, ASA, Cu‐PLA, PC, PETG, and commercial materials like Teflon sheets, PA6,6 conductive sheets, indium tin oxide‐coated polyethylene terephthalate, conductive‐nylon sheets, and PVDF membrane are selected as negative triboelectric materials. The maximum AC voltage of 80 V and maximum instantaneous current of 0.9 μA are produced by pairing 3DP‐PA12 and 3DP‐Veroclear under open circuit condition. This AC output is further converted to DC output using brdige rectifier circuitry to efficiently charge up the capacitor and glow series of 16 LEDs.
Wang, Y, Weng, S, Tang, Y, Lin, S, Liu, X, Zhang, W, Liu, G, Pandi, B, Wu, Y, Ma, L & Wang, L 2024, 'A transmembrane scaffold from CD20 helps recombinant expression of a chimeric claudin 18.2 in an in vitro coupled transcription and translation system', Protein Expression and Purification, vol. 215, pp. 106392-106392.
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Wang, Y, Yang, X, Meng, Y, Wen, Z, Han, R, Hu, X, Sun, B, Kang, F, Li, B, Zhou, D, Wang, C & Wang, G 2024, 'Fluorine Chemistry in Rechargeable Batteries: Challenges, Progress, and Perspectives', Chemical Reviews, vol. 124, no. 6, pp. 3494-3589.
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Ward, J, Coakley, L, Grisedale, K, Seddon, S, Spiden, M, Watson, JL & McNevin, D 2024, 'Operationalization of the National DNA Program for Unidentified and Missing Persons' Forensic Investigative Genetic Genealogy Capability for Human Remains Identification in Australia', Forensic Genomics, vol. 4, no. 1, pp. 32-40.
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Waszczuk, JR, Peacock, L, Chadwick, S, Maynard, P, Raymond, J & Roux, C 2024, 'Misidentifications of alphanumeric characters in serial number restorations', Australian Journal of Forensic Sciences, vol. 56, no. 2, pp. 168-188.
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Chemical etching has long been established as a reliable means of recovering defaced characters such as serial numbers. Although successful restorations can present clearly defined characters, a preliminary assessment of proficiency test results shows varied participant interpretations of samples marked with the same characters. Thus, a study was completed to determine if specific alphanumeric characters are more likely to be misidentified, comprising a practical exercise and analysis of 16 compiled proficiency test results. The practical exercise involved 64 steel plates stamped with six randomized characters that were removed and chemically restored. Participants individually assessed the plates and provided their interpretations. A total of 39 participants of various backgrounds and experience in serial number restorations were used in this study. After comparing participant interpretations with the ground truth, characters more prone to be misidentified were determined. The proficiency test results showed that the most frequently misidentified characters were the letters B and N, among a limited set. Whilst the practical assessment found a notable increase in misidentifications for the letters G, Q and S. Interestingly, none of these characters were used in the proficiency tests. It is hoped that the results of this study raise awareness for forensic examiners undertaking restorations.
Watson, J, McNevin, D, Grisedale, K, Spiden, M, Seddon, S & Ward, J 2024, 'Operationalisation of the ForenSeq® Kintelligence Kit for Australian unidentified and missing persons casework', Forensic Science International: Genetics, vol. 68, pp. 102972-102972.
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Single nucleotide polymorphism (SNP) genotyping technologies can generate investigative leads for human remains identification, including estimation of biological sex, biogeographical ancestry (BGA), externally visible characteristics (EVCs), identity, uniparental lineage and extended kinship. The ForenSeq® Kintelligence Kit provides forensic laboratories with the ability to apply this suite of genetic tools to forensic samples using one panel targeting 10,230 SNPs (including 56 ancestry-informative, 24 phenotype-informative, 94 identity-informative, 106 X chromosome, 85 Y chromosome and 9867 kinship-informative SNPs) sequenced on the MiSeq FGx® Sequencing System. The ForenSeq® Kintelligence Kit has been internally validated, optimised and operationalised by the Australian Federal Police National DNA Program for Unidentified and Missing Persons (AFP Program) for coronial casework. The internal validation was conducted according to the Scientific Working Group on DNA Analysis Methods guidelines (excluding mixture analysis), focussing on sample types typically encountered in human remains identification casework, such as bones, teeth, nail, blood and hair. The workflow was optimised for a high throughput library preparation and sequencing workflow, and additional analytical thresholds were developed to improve genotyping accuracy for low DNA input samples. Additionally, the genetic intelligence generated from the kit was compared to the self-declared biological sex, EVCs and BGA of the DNA donors to assess concordance. The kit was able to produce high quality SNP profiles from 1.0 ng down to 0.1 ng of DNA, with high repeatability and reproducibility, and minimal background noise. The prediction accuracy for biological sex (95%), hair colour (58%), eye colour (74%) and BGA inferences (consistent: 74%; partially consistent: 10%; inconclusive: 16%) was determined based on self-declared data. Additionally, SNP profiles from a volunteer family group of ten rel...
Watson, JL, McNevin, D & Ward, J 2024, 'Genetic Kinship Testing Techniques for Human Remains Identification and Missing Persons Investigations', Forensic Genomics, vol. 4, no. 1, pp. 4-23.
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Weyermann, C, Willis, S, Margot, P & Roux, C 2024, 'Response to the letter to the Editor commenting on “Towards more relevance in forensic science research and development” by Weyermann et al.', Forensic Science International, vol. 355, pp. 111928-111928.
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Windhagauer, M, Doblin, MA, Signal, B, Kuzhiumparambil, U, Fabris, M & Abbriano, RM 2024, 'Metabolic response to a heterologous poly-3-hydroxybutyrate (PHB) pathway in Phaeodactylum tricornutum', Applied Microbiology and Biotechnology, vol. 108, no. 1, pp. 1-16.
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Wright, K, Han, DJY, Song, R, de Silva, K, Plain, KM, Purdie, AC, Shepherd, A, Chin, M, Hortle, E, Wong, JJ-L, Britton, WJ & Oehlers, SH 2024, 'Zebrafishtsc1andcxcl12aincrease susceptibility to mycobacterial infection', Life Science Alliance, vol. 7, no. 4, pp. e202302523-e202302523.
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Regulation of host miRNA expression is a contested node that controls the host immune response to mycobacterial infection. The host must counter subversive efforts of pathogenic mycobacteria to launch a protective immune response. Here, we examine the role of miR-126 in the zebrafish–Mycobacterium marinuminfection model and identify a protective role for infection-induced miR-126 through multiple effector pathways. We identified a putative link between miR-126 and thetsc1aandcxcl12a/ccl2/ccr2signalling axes resulting in the suppression of non-tnfaexpressing macrophage accumulation at earlyM. marinumgranulomas. Mechanistically, we found a detrimental effect oftsc1aexpression that renders zebrafish embryos susceptible to higher bacterial burden and increased cell death via mTOR inhibition. We found that macrophage recruitment driven by thecxcl12a/ccl2/ccr2signalling axis was at the expense of the recruitment of classically activatedtnfa-expressing macrophages and increased cell death around granulomas. Together, our results delineate putative pathways by which infection-induced miR-126 may shape an effective immune response toM. marinuminfection in zebrafish embryos.
Wyrsch, ER, Hoye, BJ, Sanderson-Smith, M, Gorman, J, Maute, K, Cummins, ML, Jarocki, VM, Marenda, MS, Dolejska, M & Djordjevic, SP 2024, 'The faecal microbiome of the Australian silver gull contains phylogenetically diverse ExPEC, aEPEC and Escherichia coli carrying the transmissible locus of stress tolerance', Science of The Total Environment, vol. 919, pp. 170815-170815.
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Xiang, M, Jiang, Y, Zhou, J, Bao, G, Luo, X, Zhang, L, Jin, D, Xian, Y & Zhang, C 2024, 'NIR light-controlled DNA nanodevice for amplified mRNA imaging and precise gene therapy', Nano Today, vol. 54, pp. 102110-102110.
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Xu, J, Li, H, Jin, Y, Zhou, D, Sun, B, Armand, M & Wang, G 2024, 'Understanding the Electrical Mechanisms in Aqueous Zinc Metal Batteries: From Electrostatic Interactions to Electric Field Regulation', Advanced Materials, vol. 36, no. 3, p. e2309726.
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AbstractAqueous Zn metal batteries are considered as competitive candidates for next‐generation energy storage systems due to their excellent safety, low cost, and environmental friendliness. However, the inevitable dendrite growth, severe hydrogen evolution, surface passivation, and sluggish reaction kinetics of Zn metal anodes hinder the practical application of Zn metal batteries. Detailed summaries and prospects have been reported focusing on the research progress and challenges of Zn metal anodes, including electrolyte engineering, electrode structure design, and surface modification. However, the essential electrical mechanisms that significantly influence Zn2+ ions migration and deposition behaviors have not been reviewed yet. Herein, in this review, the regulation mechanisms of electrical‐related electrostatic repulsive/attractive interactions on Zn2+ ions migration, desolvation, and deposition behaviors are systematically discussed. Meanwhile, electric field regulation strategies to promote the Zn2+ ions diffusion and uniform Zn deposition are comprehensively reviewed, including enhancing and homogenizing electric field intensity inside the batteries and adding external magnetic/pressure/thermal field to couple with the electric field. Finally, future perspectives on the research directions of the electrical‐related strategies for building better Zn metal batteries in practical applications are offered.
Xu, J, Qiu, Y, Yang, J, Li, H, Han, P, Jin, Y, Liu, H, Sun, B & Wang, G 2024, 'Review of Separator Modification Strategies: Targeting Undesired Anion Transport in Room Temperature Sodium–Sulfur/Selenium/Iodine Batteries', Advanced Functional Materials, vol. 34, no. 2.
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AbstractRechargeable sodium–sulfur/selenium/iodine (Na–S/Se/I2) batteries are regarded as promising candidates for large‐scale energy storage systems, with the advantages of high energy density, low cost, and environmental friendliness. However, the electrochemical performances of Na–S/Se/I2 batteries are still restricted by several inherent issues, including the “shuttle effect” of polysulfides/polyselenides/polyiodides (PSs/PSes/PIs), sluggish kinetics of the conversion reactions at the cathodes, and Na dendrite growth at the anodes. Among these challenges, uncontrolled “shuttle effect” of PSs/PSes/PIs is a major contributing factor for the irreversible loss of active cathode materials and severe side reactions on Na metal anodes, leading to rapid failure of the batteries. Separator modification has been demonstrated to be an effective strategy to suppress the shuttling of PSs/PSes/PIs. Herein, the latest achievement in modifying separators for high‐performance Na–S/Se/I2 batteries is comprehensively reviewed. The reaction mechanisms of each battery system are first discussed. Then, strategies of separator modification based on the different functions for regulating the transportation of PSs/PSes/PIs are summarized, including applying electrostatic repulsive interaction, introducing conductive layers, improving sieving effects, enhancing chemisorption capability, and adding efficient electrocatalysts. Finally, future perspectives on the practical application of modified separators in high‐energy rechargeable batteries are provided.
Xu, J, Yang, J, Qiu, Y, Jin, Y, Wang, T, Sun, B & Wang, G 2024, 'Achieving high-performance sodium metal anodes: From structural design to reaction kinetic improvement', Nano Research, vol. 17, no. 3, pp. 1288-1312.
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AbstractSodium metal is one of the ideal anodes for high-performance rechargeable batteries because of its high specific capacity (~ 1166 mAh·g−1), low reduction potential (−2.71 V compared to standard hydrogen electrodes), and low cost. However, the unstable solid electrolyte interphase, uncontrolled dendrite growth, and inevitable volume expansion hinder the practical application of sodium metal anodes. At present, many strategies have been developed to achieve stable sodium metal anodes. Here, we systematically summarize the latest strategies adopted in interface engineering, current collector design, and the emerging methods to improve the reaction kinetics of sodium deposition processes. First, the strategies of constructing protective layers are reviewed, including inorganic, organic, and mixed protective layers through electrolyte additives or pretreatments. Then, the classification of metal-based, carbon-based, and composite porous frames is discussed, including their function in reducing local deposition current density and the effect of introducing sodiophilic sites. Third, the recent progress of alloys, nanoparticles, and single atoms in improving Na deposition kinetics is systematically reviewed. Finally, the future research direction and the prospect of high-performance sodium metal batteries are proposed.
Yin, M, Wadhwa, R, Marshall, JE, Gillis, CM, Kim, RY, Dua, K, Palsson-McDermott, EM, Fallon, PG, Hansbro, PM & O’Neill, LAJ 2024, '4-Octyl Itaconate Alleviates Airway Eosinophilic Inflammation by Suppressing Chemokines and Eosinophil Development', The Journal of Immunology, vol. 212, no. 1, pp. 13-23.
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Abstract 4-Octyl itaconate (4-OI) is a derivative of the Krebs cycle–derived metabolite itaconate and displays an array of antimicrobial and anti-inflammatory properties through modifying cysteine residues within protein targets. We have found that 4-OI significantly reduces the production of eosinophil-targeted chemokines in a variety of cell types, including M1 and M2 macrophages, Th2 cells, and A549 respiratory epithelial cells. Notably, the suppression of these chemokines in M1 macrophages was found to be NRF2-dependent. In addition, 4-OI can interfere with IL-5 signaling and directly affect eosinophil differentiation. In a model of eosinophilic airway inflammation in BALB/c mice, 4-OI alleviated airway resistance and reduced eosinophil recruitment to the lungs. Our findings suggest that itaconate derivatives could be promising therapeutic agents for the treatment of eosinophilic asthma.
Zhang, L, Jiang, M, Tian, H, Liu, S, Zhou, X, Liu, H, Gan, S, Che, S, Chen, Z, Li, Y, Wang, T, Wang, G & Wang, C 2024, 'Oxygen and Nitrogen Vacancies in a BiOBr/g-C3N4 Heterojunction for Sustainable Solar Ammonia Fertilizer Synthesis', ACS Sustainable Chemistry & Engineering, vol. 12, no. 5, pp. 2028-2040.
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Zhang, Q, Lai, N, He, M, Yang, Y, Huang, Q, Quan, Y, Hou, S, Gao, X, Song, Y, Liao, J & Wang, R 2024, 'Tunable broadband luminescence of Bi‐ion‐doped glasses via Gd2O3 co‐doping', Journal of the American Ceramic Society, vol. 107, no. 6, pp. 3837-3844.
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AbstractThe doping of bismuth (Bi) ions in borosilicate glasses has gained attention for its potential applications in LED light sources and imaging displays. Here, gadolinium oxide (Gd2O3) was introduced into the glass matrix in varying concentrations using a high‐temperature melting method to investigate its impact on the luminescence properties of Bi ions. The resulting glass exhibited bimodal emission peaks at 465 and 750 nm when excited with 325 nm light. The luminescence intensity and fluorescence half width at half height initially increased, followed by a subsequent decrease as the Gd2O3 content in the glass increased from 10 to 43 mol%. Additionally, the color of the luminescence transformed from purple–red to green under white light irradiation. The composition and excitation wavelength of the glass can be adjusted to achieve selective tuning of the luminescence.
Zhao, F, Guan, Y, Su, F, Du, Z, Wen, S, Zhang, L & Jin, D 2024, 'Lanthanide-Complex-Enhanced Bioorthogonal Branched DNA Amplification', Analytical Chemistry, vol. 96, no. 4, pp. 1556-1564.
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Zhao, S, Li, G, Zhang, B, Li, T, Luo, M, Sun, B, Wang, G & Guo, S 2024, 'Technological roadmap for potassium-ion hybrid capacitors', Joule.
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Zhou, X, zhang, L, Liu, H, Yang, Q, Zhu, S, Wu, H, Ohno, T, Zhang, Y, Wang, T, Su, D & Wang, C 2024, 'The powerful combination of 2D/2D Ni-MOF/carbon nitride for deep desulfurization of thiophene in fuel: Conversion route, DFT calculation, mechanism', Journal of Colloid and Interface Science, vol. 658, pp. 627-638.
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Zhu, X, Ma, X, Zhang, Z, Liu, Y, Luo, Y, Yan, K, Pei, T & Huete, A 2024, 'Floating in the air: forecasting allergenic pollen concentration for managing urban public health', International Journal of Digital Earth, vol. 17, no. 1.
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