Abell-King, C, Pokhrel, A, Rice, SA, Duggin, IG & Söderström, B 2024, 'Multispecies bacterial invasion of human host cells', Pathogens and Disease, vol. 82.
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Abstract Urinary tract infection (UTI), one of the most common bacterial infections worldwide, is a typical example of an infection that is often polymicrobial in nature. While the overall infection course is known on a macroscale, bacterial behavior is not fully understood at the cellular level and bacterial pathophysiology during multispecies infection is not well characterized. Here, using clinically relevant bacteria, human epithelial bladder cells and human urine, we establish co-infection models combined with high resolution imaging to compare single- and multi-species bladder cell invasion events in three common uropathogens: uropathogenic Escherichia coli (UPEC), Klebsiella pneumoniae and Enterococcus faecalis. While all three species invaded the bladder cells, under flow conditions the Gram-positive E. faecalis was significantly less invasive compared to the Gram-negative UPEC and K. pneumoniae. When introduced simultaneously during an infection experiment, all three bacterial species sometimes invaded the same bladder cell, at differing frequencies suggesting complex interactions between bacterial species and bladder cells. Inside host cells, we observed encasement of E. faecalis colonies specifically by UPEC. During subsequent dispersal from the host cells, only the Gram-negative bacteria underwent infection-related filamentation (IRF). Taken together, our data suggest that bacterial multispecies invasions of single bladder cells are frequent and support earlier studies showing intraspecies cooperation on a biochemical level during UTI.
Adedipe, DT, Chen, C, Lai, RWS, Xu, S, Luo, Q, Zhou, G-J, Boxall, A, Brooks, BW, Doblin, MA, Wang, X, Wang, J & Leung, KMY 2024, 'Occurrence and potential risks of pharmaceutical contamination in global Estuaries: A critical review and analysis', Environment International, vol. 192, pp. 109031-109031.
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Adil, M, Mahmud, MAP, Kouzani, AZ & Khoo, SY 2024, 'Optimal Location and Pricing of Electric Vehicle Charging Stations Using Machine Learning and Stackelberg Game', IEEE Transactions on Industry Applications, vol. 60, no. 3, pp. 4708-4722.
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Akhileshwar Jha, L, Imran, M, Shrestha, J, Prasad Devkota, H, Bhattacharya, K, Alsayari, A, Wahab, S, Kumar Jha, S, Raj Paudel, K & Kesharwani, P 2024, 'Effectiveness of phytoconstituents and potential of phyto-nanomedicines combination to treat osteoarthritis', European Polymer Journal, vol. 215, pp. 113243-113243.
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Akkaya Hocagil, T, Ryan, LM, Cook, RJ, Dang, K, Carter, RC, Richardson, GA, Day, NL, Coles, CD, Carmichael Olson, H, Jacobson, SW & Jacobson, JL 2024, 'Benchmark dose profiles for bivariate exposures', Risk Analysis, vol. 44, no. 10, pp. 2415-2428.
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AbstractWhile benchmark dose (BMD) methodology is well‐established for settings with a single exposure, these methods cannot easily handle multidimensional exposures with nonlinear effects. We propose a framework for BMD analysis to characterize the joint effect of a two‐dimensional exposure on a continuous outcome using a generalized additive model while adjusting for potential confounders via propensity scores. This leads to a dose–response surface which can be summarized in two dimensions by a contour plot in which combinations of exposures leading to the same expected effect are identified. In our motivating study of prenatal alcohol exposure, cognitive deficits in children are found to be associated with both the frequency of drinking as well as the amount of alcohol consumed on each drinking day during pregnancy. The general methodological framework is useful for a broad range of settings, including combinations of environmental stressors, such as chemical mixtures, and in explorations of the impact of dose rate rather than simply cumulative exposure on adverse outcomes.
Alderdice, R, Voolstra, CR, Lendo, CIN, Boote, C, Suggett, DJ, Edmondson, J, Goyen, S, Haydon, T & Camp, EF 2024, 'Loss of coral thermotolerance following year-long in situ nursery propagation with a consecutively high summer heat-load', Coral Reefs, vol. 43, no. 4, pp. 919-933.
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AbstractExposure to more frequent ocean warming events is driving the loss of coral reef cover as the window of recovery between episodes of bleaching reduces. Coral propagation via in situ nurseries and subsequent outplanting have increased worldwide to support replenishing coral cover on degraded reefs. However, challenges in identifying fast-growing and bleaching-resistant target corals have limited how informative we can be regarding the resilience of outplanted corals. Here, we employed short-term thermal stress assays using the Coral Bleaching Automated Stress System (CBASS) to assess the thermal threshold of a fast-growing coral pre- and post-propagation on in situ nursery frames. We show that year-long nursery-propagated corals exhibit a statistically significant reduction in thermal thresholds (i.e., ED50s) compared to their corresponding reef-based donor colonies based on dose–response modelling of dark acclimated photosynthetic efficiency. RNA-Seq was then used to assess the underlying drivers of this thermotolerance reduction, identifying that processes involved in metabolic and oxidative stress management were disrupted in nursery versus donor heat-treated corals. Whether trade-offs during potential growth-focused phases (post-fragmentation), nursery conditions, and/or a consecutively high summer heat-load drove the lower thermal capacity remains to be determined. However, nursery corals expressed genes associated with telomere maintenance, which are typically expressed in stress-sensitive fast-growing corals under seasonal environmental stress, suggesting consecutively high summer heat-loading contributed to the observed patterns. Our results highlight that thermal tolerance is (i) variable and (ii) subject to acclimation to varying degrees across colonies. Thus, a path forward for reef practitioners to improve propagation efforts may entail the initial screening of a larger reef population from which the...
Aljumaili, T & Haines, AM 2024, 'An evaluation of the RapidHIT™ ID system for hair roots stained with Diamond™ Nucleic Acid Dye', Forensic Science International: Genetics, vol. 69, pp. 103003-103003.
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Aljumaili, T, Riley, B, Bruce, D & Haines, AM 2024, 'Triaging of hair samples using fluorescent in situ detection', Australian Journal of Forensic Sciences, vol. 56, no. sup1, pp. 17-19.
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Allam, VSRR, Patel, VK, De Rubis, G, Paudel, KR, Gupta, G, Chellappan, DK, Singh, SK, Hansbro, PM, Oliver, BGG & Dua, K 2024, 'Exploring the role of the ocular surface in the lung-eye axis: Insights into respiratory disease pathogenesis', Life Sciences, vol. 349, pp. 122730-122730.
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Alzahrani, SA, De Silva, KSB, Dowd, A, Arnold, MD & Cortie, MB 2024, 'Effect of precursor composition and heat-treatment on the morphology and physical properties of Ag nanosponges', Results in Surfaces and Interfaces, vol. 15, pp. 100217-100217.
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Angeloski, A, Flower‐Donaldson, K, Matar, F, Hayes, DC, Duman, MN, Oldfield, DT, Westerhausen, MT & McDonagh, AM 2024, 'Gold Microstructures by Thermolysis of Gold(III) Di‐isopropyldithiocarbamate Complexes', ChemNanoMat, vol. 10, no. 3.
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AbstractElemental gold was formed by thermolysis of gold(III) dithiocarbamate single‐source precursors, which exist as two complexes. The complexes were readily synthesised from the reaction between chloroauric acid and sodium di‐isopropyldithiocarbamate and could be isolated from each other. The thermal decomposition processes were evaluated using thermogravimetry and electrical resistance measurements. The structure and purity of the resultant gold was examined using scanning electron microscopy. The resultant gold materials were drastically different and dependent on the thermolysed complex.
Armitage, CW, O'Meara, CP, Bryan, ER, Kollipara, A, Trim, LK, Hickey, D, Carey, AJ, Huston, WM, Donnelly, G, Yazdani, A, Blumberg, RS & Beagley, KW 2024, 'IgG exacerbates genital chlamydial pathology in females by enhancing pathogenic CD8+ T cell responses', Scandinavian Journal of Immunology, vol. 99, no. 1.
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AbstractChlamydia trachomatis infections are an important sexually transmitted infection that can lead to inflammation, scarring and hydrosalpinx/infertility. However, infections are commonly clinically asymptomatic and do not receive treatment. The underlying cause of asymptomatic immunopathology remains unknown. Here, we demonstrate that IgG produced during male infection enhanced the incidence of immunopathology and infertility in females. Human endocervical cells expressing the neonatal Fc Receptor (FcRn) increased translocation of human IgG‐opsonized C. trachomatis. Using total IgG purified from infected male mice, we opsonized C. muridarum and then infected female mice, mimicking sexual transmission. Following infection, IgG‐opsonized Chlamydia was found to transcytose the epithelial barrier in the uterus, where it was phagocytosed by antigen‐presenting cells (APCs) and trafficked to the draining lymph nodes. APCs then expanded both CD4+ and CD8+ T cell populations and caused significantly more infertility in female mice infected with non‐opsonized Chlamydia. Enhanced phagocytosis of IgG‐opsonized Chlamydia significantly increased pro‐inflammatory signalling and T cell proliferation. As IgG is transcytosed by FcRn, we utilized FcRn−/− mice and observed that shedding kinetics of Chlamydia were only affected in FcRn−/− mice infected with IgG‐opsonized Chlamydia. Depletion of CD8+ T cells in FcRn−/− mice lead to a significant reduction in the incidence of infertility. Taken together, these data demonstrate that IgG seroconversion during male infection can amplify female immunopathol...
Ashique, S, Mishra, N, Garg, A, Garg, S, Farid, A, Rai, S, Gupta, G, Dua, K, Paudel, KR & Taghizadeh-Hesary, F 2024, 'A Critical Review on the Long-Term COVID-19 Impacts on Patients With Diabetes', The American Journal of Medicine.
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Ashrafinia, F, Chen, H, Heydari, O, Mirzaei, M & Abdi, F 2024, 'The Importance of Personal and Familial Factors on Breastfeeding Intention and Practices, and Postpartum Distress during the Pandemic: A Longitudinal Observational Study', Maternal and Child Health Journal, vol. 28, no. 3, pp. 513-523.
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Bahatheg, G, Kuppusamy, R, Yasir, M, Bridge, S, Mishra, SK, Cranfield, CG, StC. Black, D, Willcox, M & Kumar, N 2024, 'Dimeric peptoids as antibacterial agents', Bioorganic Chemistry, vol. 147, pp. 107334-107334.
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Bai, X, Xu, Z, Zi, Y, Zhao, H, Zhu, B, Feng, R, Cun, Y, Huang, A, Liu, Y, Li, Y, Qiu, J, Song, Z, Langford, SJ, Liao, J & Yang, Z 2024, 'Dual‐Functional X‐Ray Photochromic Phosphor: High‐Performance Detection and 3D Imaging', Advanced Functional Materials, vol. 34, no. 37.
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AbstractThis study explores the integration of X‐ray‐induced photochromism and photoluminescence in a single material, offering innovative multi‐mode applications in optical memory, anti‐counterfeiting, and X‐ray detection and imaging. The photochromic phosphor LiAlSi2O6:Sm3+ is synthesized, which undergoes a color change from white to dark green under bright field conditions and displays orange photoluminescence in dark field conditions after X‐ray exposure due to defect formation. The phosphor shows accelerated bleaching and recovery under 473 nm laser stimulation. The distinct X‐ray‐induced color contrast and luminescence intensity modification in LiAlSi2O6:Sm3+ highlight its potential in advanced luminescent material design. Moreover, a LiAlSi2O6:Sm3+‐based flexible film demonstrates “dual‐mode” 3D X‐ray imaging and detection capabilities, paving the way for future X‐ray detecting and imaging device research.
Balzer, MJ, Hitchcock, JN, Kobayashi, T, Westhorpe, DP, Boys, C & Mitrovic, SM 2024, 'Flow event size influences carbon, nutrient and zooplankton dynamics in a highly regulated lowland river', Hydrobiologia, vol. 851, no. 5, pp. 1319-1334.
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AbstractRiver regulation and water extraction has significantly altered flow regimes and reduced flood events in many inland river systems. Environmental flows have been adopted in many systems to mitigate the ecological impacts of river regulation, however a lack of knowledge regarding the interrelationship between flow regimes, carbon transport and instream productivity make prioritising water management difficult. To address this knowledge gap, we conducted a study on the Namoi River in the Murray-Darling Basin, Australia, monitoring changes in dissolved organic carbon (DOC), nutrient dynamics and planktonic food web structure during a period of variable flows. Nutrient and DOC concentrations were positively correlated with river discharge and zooplankton concentrations were highest post flow events. Planktonic chlorophyll-a, increased DOC concentration and higher discharge were the most influential drivers of change in zooplankton communities. Further, our results indicated that flow events increased production through both heterotrophic and autotrophic pathways, significantly boosting zooplankton concentration compared to base flow conditions across all measured flow events. We suggest even small in-channel flow events can be important for increasing basal and zooplankton production in rivers, and therefore should be protected or promoted by environmental flow management, particularly during drought conditions.
Bani Saeid, A, De Rubis, G, Williams, KA, Yeung, S, Chellappan, DK, Singh, SK, Gupta, G, Hansbro, PM, Shahbazi, M-A, Gulati, M, Kaur, IP, Santos, HA, Paudel, KR & Dua, K 2024, 'Revolutionizing lung health: Exploring the latest breakthroughs and future prospects of synbiotic nanostructures in lung diseases', Chemico-Biological Interactions, vol. 395, pp. 111009-111009.
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Bani Saeid, A, Paudel, KR, De Rubis, G, Mehndiratta, S, Kokkinis, S, Vishwas, S, Yeung, S, Gupta, G, Singh, SK & Dua, K 2024, 'Fisetin-loaded nanoemulsion ameliorates lung cancer pathogenesis via downregulating cathepsin-B, galectin-3 and enolase in an in vitro setting', EXCLI Journal, vol. 23, pp. 1238-1244.
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Banik, M, Paudel, KR, Majumder, R & Idrees, S 2024, 'Prediction of virus–host interactions and identification of hot spot residues of DENV-2 and SH3 domain interactions', Archives of Microbiology, vol. 206, no. 4.
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AbstractDengue virus, particularly serotype 2 (DENV-2), poses a significant global health threat, and understanding the molecular basis of its interactions with host cell proteins is imperative for developing targeted therapeutic strategies. This study elucidated the interactions between proline-enriched motifs and Src homology 3 (SH3) domain. The SH3 domain is pivotal in mediating protein–protein interactions, particularly by recognizing and binding to proline-rich regions in partner proteins. Through a computational pipeline, we analyzed the interactions and binding modes of proline-enriched motifs with SH3 domains, identified new potential DENV-2 interactions with the SH3 domain, and revealed potential hot spot residues, underscoring their significance in the viral life cycle. This comprehensive analysis provides crucial insights into the molecular basis of DENV-2 infection, highlighting conserved and serotype-specific interactions. The identified hot spot residues offer potential targets for therapeutic intervention, laying the foundation for developing antiviral strategies against Dengue virus infection. These findings contribute to the broader understanding of viral–host interactions and provide a roadmap for future research on Dengue virus pathogenesis and treatment.
Barash, M, McNevin, D, Fedorenko, V & Giverts, P 2024, 'Machine learning applications in forensic DNA profiling: A critical review', Forensic Science International: Genetics, vol. 69, pp. 102994-102994.
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Bartels, N, Camp, EF, Dilernia, NJ & Suggett, DJ 2024, 'Regulation of cultured coral endosymbiont photophysiology by alternate heat stress protocols', Marine Biology, vol. 171, no. 1.
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Bashir, B, Alam, S, Khandale, N, Birla, D, Vishwas, S, Pandey, NK, Gupta, G, Paudel, KR, Dureja, H, Kumar, P, Singh, TG, Kuppusamy, G, Zacconi, FC, Pinto, TDJA, Dhanasekaran, M, Gulati, M, Dua, K & Singh, SK 2024, 'Opening avenues for treatment of neurodegenerative disease using post-biotics: Breakthroughs and bottlenecks in clinical translation', Ageing Research Reviews, vol. 95, pp. 102236-102236.
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Bati, ASR, Myagmarsereejid, P, Fronzi, M, Fan, K, Liu, P, Zhong, YL, Burn, PL, Gentle, IR, Shaw, PE & Batmunkh, M 2024, 'Atomically Doped 2D Black Phosphorus for Efficient and Stable Perovskite Solar Cells', Small Structures, vol. 5, no. 2.
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Controlled functionalization of 2D black phosphorus (BP) nanosheets provides unique opportunities to tune their chemical, physical, and electronic properties. Herein, the preparation of single‐atom nickel‐doped BP (Ni–BP) sheets using a simple solution‐based strategy is reported. Using the Ni–BP sheets as a passivation layer on top of a perovskite film leads to standard perovskite solar cells (PSCs) with improved performance. The standard n–i–p PSCs with the Ni–BP interlayer achieve maximum power conversion efficiencies of over 22%, with negligible hysteresis and a modest improvement in stability when subjected to different testing conditions. The perovskite films prepared with Ni–BP sheets‐based passivation are found to have reduced defect densities as well as improved charge‐transfer properties and carrier lifetimes. Density‐functional theory calculations support the experimental results through showing that the atomic Ni‐doping increases the work function of the BP interlayer, enabling better hole extraction, as well as increasing the surface hydrophobicity of the BP layer, hence reducing water sorption into the perovskite film.
Bellotto, C, Fowler, AM & Booth, DJ 2024, 'Individual performance niches and responses to winter temperature change in three estuarine fishes from eastern Australia', Marine Biology, vol. 171, no. 10.
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AbstractClimate change may impact individual organisms in different ways, a consideration often overshadowed by predominant focus on population effects in studies. We examined three estuarine fish species to determine if individual fish performance, persisted across winter water temperatures. Fish performance at 16 °C (current Sydney winter estuarine water temperature) and 20 °C (predicted under climate change) with low and high food regimes was assessed using key physiological (growth, aerobic scope, burst speed) and behavioural parameters (foraging activity, boldness, shelter usage, predator escape response). We expected a strong positive relationship between performance at 16 °C and 20 °C for each parameter, and interactions with food level, however in general this was not found for any species. Relative performance was only maintained across temperatures for a few parameters, such as bite rate, boldness, and shelter response in one species (trumpeter Pelates sexlineatus), with aerobic scope in silver biddy Gerres subfasciatus, and boldness in fortescue Centropogon australis. Our results suggest that individuals’ fitness (directly via changes in growth, indirectly via behaviours) might be impacted by climate warming due to differences in relative performance among juvenile individuals across water temperatures. Changes in relative performance among individuals may initially compensate for a population-level response, thereby buffering the effects of climate change.
Bhadra, A, Wei, R, Keogh, R, Kipnis, V, Midthune, D, Buckman, DW, Su, Y, Chowdhury, AR & Carroll, RJ 2024, 'Measurement error models with zero inflation and multiple sources of zeros, with applications to hard zeros', Lifetime Data Analysis, vol. 30, no. 3, pp. 600-623.
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Bhat, AA, Afzal, M, Goyal, A, Gupta, G, Thapa, R, almalki, WH, Kazmi, I, Alzarea, SI, Shahwan, M, Paudel, KR, Ali, H, Sahu, D, Prasher, P, Singh, SK & Dua, K 2024, 'The impact of formaldehyde exposure on lung inflammatory disorders: Insights into asthma, bronchitis, and pulmonary fibrosis', Chemico-Biological Interactions, vol. 394, pp. 111002-111002.
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Bhattacharjee, NV, Schumacher, AE, Aali, A, Abate, YH, Abbasgholizadeh, R, Abbasian, M, Abbasi-Kangevari, M, Abbastabar, H, Abd ElHafeez, S, Abd-Elsalam, S, Abdollahi, M, Abdollahifar, M-A, Abdoun, M, Abdullahi, A, Abebe, M, Abebe, SS, Abiodun, O, Abolhassani, H, Abolmaali, M, Abouzid, M, Aboye, GB, Abreu, LG, Abrha, WA, Abrigo, MRM, Abtahi, D, Abualruz, H, Abubakar, B, Abu-Gharbieh, E, Abu-Rmeileh, NME, Adal, TGG, Adane, MM, Adeagbo, OAA, Adedoyin, RA, Adekanmbi, V, Aden, B, Adepoju, AV, Adetokunboh, OO, Adetunji, JB, Adeyinka, DA, Adeyomoye, OI, Adnani, QES, Adra, S, Afolabi, RF, Afyouni, S, Afzal, MS, Afzal, S, Aghamiri, S, Agodi, A, Agyemang-Duah, W, Ahinkorah, BO, Ahlstrom, AJ, Ahmad, A, Ahmad, D, Ahmad, F, Ahmad, MM, Ahmad, S, Ahmad, T, Ahmed, A, Ahmed, A, Ahmed, H, Ahmed, LA, Ahmed, MS, Ahmed, SA, Ajami, M, Aji, B, Akalu, GT, Akbarialiabad, H, Akinyemi, RO, Akkaif, MA, Akkala, S, Al Hamad, H, Al Hasan, SM, Al Qadire, M, AL-Ahdal, TMA, Alalalmeh, SO, Alalwan, TA, Al-Aly, Z, Alam, K, Al-amer, RM, Alanezi, FM, Alanzi, TM, Albakri, A, Albashtawy, M, AlBataineh, MT, Alemi, H, Alemi, S, Alemu, YM, Al-Eyadhy, A, Al-Gheethi, AAS, Alhabib, KF, Alhajri, N, Alhalaiqa, FAN, Alhassan, RK, Ali, A, Ali, BA, Ali, L, Ali, MU, Ali, R, Ali, SSS, Alif, SM, Aligol, M, Alijanzadeh, M, Aljasir, MAM, Aljunid, SM, Al-Marwani, S, Almazan, JU, Al-Mekhlafi, HM, Almidani, O, Alomari, MA, Al-Omari, B, Alqahtani, JS, Alqutaibi, AY, Al-Raddadi, RM, Al-Sabah, SK, Altaf, A, Al-Tawfiq, JA, Altirkawi, KA, Aluh, DO, Alvi, FJ, Alvis-Guzman, N, Alwafi, H, Al-Worafi, YM, Aly, H, Aly, S, Alzoubi, KH, Ameyaw, EK, Amin, TT, Amindarolzarbi, A, Amini-Rarani, M, Amiri, S, Ampomah, IG, Amugsi, DA, Amusa, GA, Ancuceanu, R, Anderlini, D, Andrade, PP, Andrei, CL, Andrei, T, Anil, A, Anil, S, Ansar, A, Ansari-Moghaddam, A, Antony, CM, Antriyandarti, E, Anvari, S, ANWAR, S, Anwer, R, Anyasodor, AE, Arabloo, J, Arabzadeh Bahri, R, Arafa, EA, Arafat, M, Araújo, AM, Aravkin, AY, Aremu, A, Aripov, T, Arkew, M, Armocida, B, Ärnlöv, J, Arooj, M, Artamonov, AA, Arulappan, J, Aruleba, RT, Arumugam, A, Asadi-Lari, M, Asemi, Z, Asgary, S, Asghariahmadabad, M, Asghari-Jafarabadi, M, Ashemo, MY, Ashraf, M, Ashraf, T, Asika, MO, Athari, SS, Atout, MMW, Atreya, A, Aujayeb, A, Ausloos, M, Avan, A, Aweke, AM, Ayele, GM, Ayyoubzadeh, SM, Azadnajafabad, S, Azevedo, RMS, Azzam, AY & et al. 2024, 'Global fertility in 204 countries and territories, 1950–2021, with forecasts to 2100: a comprehensive demographic analysis for the Global Burden of Disease Study 2021', The Lancet, vol. 403, no. 10440, pp. 2057-2099.
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Bhattacharya, K, Chanu, NR, Jha, SK, Khanal, P & Paudel, KR 2024, 'In silico design and evaluation of a multiepitope vaccine targeting the nucleoprotein of Puumala orthohantavirus', Proteins: Structure, Function, and Bioinformatics, vol. 92, no. 10, pp. 1161-1176.
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AbstractThe Puumala orthohantavirus is present in the body of the bank vole (Myodes glareolus). Humans infected with this virus may develop hemorrhagic fever accompanying renal syndrome. In addition, the infection may further lead to the failure of an immune system completely. The present study aimed to propose a possible vaccine by employing bioinformatics techniques to identify B and T‐cell antigens. The best multi‐epitope of potential immunogenicity was generated by combining epitopes. Additionally, the linkers EAAAK, AAY, and GPGPG were utilized in order to link the epitopes successfully. Further, C‐ImmSim was used to perform in silico immunological simulations upon the vaccine. For the purpose of conducting expression tests in Escherichia coli, the chimeric protein construct was cloned using Snapgene into the pET‐9c vector. The designed vaccine showed adequate results, evidenced by the global population coverage and favorable immune response. The developed vaccine was found to be highly effective and to have excellent population coverage in a number of computer‐based assessments. This work is fully dependent on the development of nucleoprotein‐based vaccines, which would constitute a significant step forward if our findings were used in developing a global vaccination to combat the Puumala virus.
Boakes, RA, Badolato, C & Rehn, S 2024, 'Taste aversion learning during successive negative contrast', Learning & Behavior, vol. 52, no. 3, pp. 272-284.
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AbstractPrevious experiments found that acceptance of saccharin by rats was reduced if they had prior experience of sucrose or some other highly palatable solution. This study tested whether such successive negative contrast (SNC) effects involve acquisition of an aversion to the new taste. In three experiments, rats were switched from sucrose exposure in Stage 1 to a less palatable solution containing a new taste in Stage 2. In Experiments 1 and 2, a novel flavor was added to a saccharin solution at the start of Stage 2. In Experiment 1, preference tests revealed a weak aversion to the added vanilla flavor in the Suc-Sacch group, while in Experiment 2 an aversion was found in the Suc-Sacch group to the salty flavor that was used, compared with controls given access either saccharin or water in Stage 1. In Experiment 3, the Suc-Quin group, given quinine solution in Stage 2, displayed a greater aversion to quinine than a Water-Quin control group. These results support the suggestion that taste aversion learning plays a role in the initial suppression of intakes in a qualitative consummatory SNC effect. However, in the light of other evidence, it seems that the unusual persistence of successive negative contrast when rats are switched from sucrose to saccharin is not due to a long-lasting reduction in the value of saccharin.
Boedijono, FS, Bood, V, Eichhorn, IA, Hansbro, PM, Slebos, D-J, van den Berge, M, Faiz, A & Pouwels, SD 2024, 'Identification of Genetic Factors Associated With DAMP Release in COPD Patients', Archivos de Bronconeumología.
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Bolton, M, Chadwick, S & Ueland, M 2024, 'The effect of human decomposition on bullet examination', Forensic Science International, vol. 362, pp. 112155-112155.
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Boyton, I, Valenzuela, SM, Collins-Praino, LE & Care, A 2024, 'Neuronanomedicine for Alzheimer’s and Parkinson’s disease: Current progress and a guide to improve clinical translation', Brain, Behavior, and Immunity, vol. 115, pp. 631-651.
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Neuronanomedicine is an emerging multidisciplinary field that aims to create innovative nanotechnologies to treat major neurodegenerative disorders, such as Alzheimer's (AD) and Parkinson's disease (PD). A key component of neuronanomedicine are nanoparticles, which can improve drug properties and demonstrate enhanced safety and delivery across the blood brain barrier, a major improvement on existing therapeutic approaches. In this review, we critically analyze the latest nanoparticle-based strategies to modify underlying disease pathology to slow or halt AD/PD progression. We find that a major roadblock for neuronanomedicine translation to date is a poor understanding of how nanoparticles interact with biological systems (i.e., bio-nano interactions), which is partly due to inconsistent reporting in published works. Accordingly, this review makes a set of specific recommendations to help guide researchers to harness the unique properties of nanoparticles and thus realise breakthrough treatments for AD/PD.
Bradfield, LA, Becchi, S & Kendig, MD 2024, 'Striatal Acetylcholine and Dopamine Interactions Produce SituationappropriateAction Selection', Current Neuropharmacology, vol. 22, no. 9, pp. 1491-1496.
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Abstract:Individuals often learn how to perform new actions for particular outcomes against a complex background of existing action-outcome associations. As such, this new knowledge can interfere or even compete with existing knowledge, such that individuals must use internal and external cues to determine which action is appropriate to the current situation. The question thus remains as to how this problem is solved at a neural level. Research over the last decade or so has begun to determine how the brain achieves situation-appropriate action selection. Several converging lines of evidence suggest that it is achieved through the complex interactions of acetylcholine and dopamine within the striatum in a manner that relies on glutamatergic inputs from the cortex and thalamus. Here we briefly review this evidence, then relate it to several very recent findings to provide new, speculative insights regarding the precise nature of striatal acetylcholine/dopamine interaction dynamics and their relation to situation-appropriate action selection.
Brauer, M, Roth, GA, Aravkin, AY, Zheng, P, Abate, KH, Abate, YH, Abbafati, C, Abbasgholizadeh, R, Abbasi, MA, Abbasian, M, Abbasifard, M, Abbasi-Kangevari, M, Abd ElHafeez, S, Abd-Elsalam, S, Abdi, P, Abdollahi, M, Abdoun, M, Abdulah, DM, Abdullahi, A, Abebe, M, Abedi, A, Abedi, A, Abegaz, TM, Abeldaño Zuñiga, RA, Abiodun, O, Abiso, TL, Aboagye, RG, Abolhassani, H, Abouzid, M, Aboye, GB, Abreu, LG, Abualruz, H, Abubakar, B, Abu-Gharbieh, E, Abukhadijah, HJJ, Aburuz, S, Abu-Zaid, A, Adane, MM, Addo, IY, Addolorato, G, Adedoyin, RA, Adekanmbi, V, Aden, B, Adetunji, JB, Adeyeoluwa, TE, Adha, R, Adibi, A, Adnani, QES, Adzigbli, LA, Afolabi, AA, Afolabi, RF, Afshin, A, Afyouni, S, Afzal, MS, Afzal, S, Agampodi, SB, Agbozo, F, Aghamiri, S, Agodi, A, Agrawal, A, Agyemang-Duah, W, Ahinkorah, BO, Ahmad, A, Ahmad, D, Ahmad, F, Ahmad, N, Ahmad, S, Ahmad, T, Ahmed, A, Ahmed, A, Ahmed, A, Ahmed, LA, Ahmed, MB, Ahmed, S, Ahmed, SA, Ajami, M, Akalu, GT, Akara, EM, Akbarialiabad, H, Akhlaghi, S, Akinosoglou, K, Akinyemiju, T, Akkaif, MA, Akkala, S, Akombi-Inyang, B, Al Awaidy, S, Al Hasan, SM, Alahdab, F, AL-Ahdal, TMA, Alalalmeh, SO, Alalwan, TA, Al-Aly, Z, Alam, K, Alam, N, Alanezi, FM, Alanzi, TM, Albakri, A, AlBataineh, MT, Aldhaleei, WA, Aldridge, RW, Alemayohu, MA, Alemu, YM, Al-Fatly, B, Al-Gheethi, AAS, Al-Habbal, K, Alhabib, KF, Alhassan, RK, Ali, A, Ali, A, Ali, BA, Ali, I, Ali, L, Ali, MU, Ali, R, Ali, SSS, Ali, W, Alicandro, G, Alif, SM, Aljunid, SM, Alla, F, Al-Marwani, S, Al-Mekhlafi, HM, Almustanyir, S, Alomari, MA, Alonso, J, Alqahtani, JS, Alqutaibi, AY, Al-Raddadi, RM, Alrawashdeh, A, Al-Rifai, RH, Alrousan, SM, Al-Sabah, SK, Alshahrani, NZ, Altaany, Z, Altaf, A, Al-Tawfiq, JA, Altirkawi, KA, Aluh, DO, Alvis-Guzman, N, Alvis-Zakzuk, NJ, Alwafi, H, Al-Wardat, MS, Al-Worafi, YM, Aly, H, Aly, S, Alzoubi, KH, Al-Zyoud, W, Amaechi, UA, Aman Mohammadi, M, Amani, R, Amiri, S, Amirzade-Iranaq, MH, Ammirati, E, Amu, H, Amugsi, DA, Amusa, GA, Ancuceanu, R, Anderlini, D, Anderson, JA, Andrade, PP, Andrei, CL, Andrei, T, Anenberg, SC, Angappan, D, Angus, C, Anil, A, Anil, S, Anjum, A, Anoushiravani, A, Antonazzo, IC, Antony, CM, Antriyandarti, E, Anuoluwa, BS, Anvari, D, Anvari, S, Anwar, S, Anwar, SL, Anwer, R, Anyabolo, EE, Anyasodor, AE, Apostol, GLC, Arabloo, J, Arabzadeh Bahri, R, Arafat, M, Areda, D, Aregawi, BB, Aremu, A & et al. 2024, 'Global burden and strength of evidence for 88 risk factors in 204 countries and 811 subnational locations, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021', The Lancet, vol. 403, no. 10440, pp. 2162-2203.
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Britton, C, Riley, B, Bruce, D & Haines, AM 2024, 'Combining Diamond™ Nucleic Acid Dye with cyanoacrylate fuming for detection of fingermarks and visualising latent DNA', Australian Journal of Forensic Sciences, vol. 56, no. sup1, pp. 174-177.
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Brown, AO, Green, PJ, Frankham, GJ, Stuart, BH & Ueland, M 2024, 'Correction to “Insights into the Effects of Violating Statistical Assumptions for Dimensionality Reduction for Chemical “-omics” Data with Multiple Explanatory Variables”', ACS Omega, vol. 9, no. 13, pp. 15724-15724.
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Buckley, T, Vuong, T, Karanam, K, Vo, PHN, Shukla, P, Firouzi, M & Rudolph, V 2024, 'Response to ‘Comment on “Using foam fractionation to estimate PFAS air-water interface adsorption behaviour at ng/L and µg/L” by T. Buckley, T. Vuong, K. Karanam, P.H.N. Vo, P. Shukla, M. Firouzi & V. Rudolph, Water research 239, 120028’', Water Research, vol. 249, pp. 120811-120811.
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Budden, KF, Shukla, SD, Bowerman, KL, Vaughan, A, Gellatly, SL, Wood, DLA, Lachner, N, Idrees, S, Rehman, SF, Faiz, A, Patel, VK, Donovan, C, Alemao, CA, Shen, S, Amorim, N, Majumder, R, Vanka, KS, Mason, J, Haw, TJ, Tillet, B, Fricker, M, Keely, S, Hansbro, N, Belz, GT, Horvat, J, Ashhurst, T, van Vreden, C, McGuire, H, Fazekas de St Groth, B, King, NJC, Crossett, B, Cordwell, SJ, Bonaguro, L, Schultze, JL, Hamilton‐Williams, EE, Mann, E, Forster, SC, Cooper, MA, Segal, LN, Chotirmall, SH, Collins, P, Bowman, R, Fong, KM, Yang, IA, Wark, PAB, Dennis, PG, Hugenholtz, P & Hansbro, PM 2024, 'Faecal microbial transfer and complex carbohydrates mediate protection against COPD', Gut, vol. 73, no. 5, pp. 751-769.
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ObjectiveChronic obstructive pulmonary disease (COPD) is a major cause of global illness and death, most commonly caused by cigarette smoke. The mechanisms of pathogenesis remain poorly understood, limiting the development of effective therapies. The gastrointestinal microbiome has been implicated in chronic lung diseases via the gut-lung axis, but its role is unclear.DesignUsing anin vivomouse model of cigarette smoke (CS)-induced COPD and faecal microbial transfer (FMT), we characterised the faecal microbiota using metagenomics, proteomics and metabolomics. Findings were correlated with airway and systemic inflammation, lung and gut histopathology and lung function. Complex carbohydrates were assessed in mice using a high resistant starch diet, and in 16 patients with COPD using a randomised, double-blind, placebo-controlled pilot study of inulin supplementation.ResultsFMT alleviated hallmark features of COPD (inflammation, alveolar destruction, impaired lung function), gastrointestinal pathology and systemic immune changes. Protective effects were additive to smoking cessation, and transfer of CS-associated microbiota after antibiotic-induced microbiome depletion was sufficient to increase lung inflammation while suppressing colonic immunity in the absence of CS exposure. Disease features correlated with the relative abundance ofMuribaculaceae, DesulfovibrionaceaeandLachnospiraceaefamily members. Proteomics and metabolomics identified downregulation of glucose and starch metabolism in CS-associated microbiota, and supplementation of mice or human patients with complex carbohydrates improved disease outcomes.ConclusionTh...
Cai, Y, Shang, Y, Lu, M, Jin, D & Zhou, J 2024, 'Polarized Upconversion of sub-100 nm Single Nanoparticles', Nano Letters, vol. 24, no. 35, pp. 10915-10920.
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Upconversion nanoparticles are popular as imaging probes due to their advantages in photostability and controllable emission dimensions. However, upconversion polarization remains largely uncharted with previous reports limited to microstructures. In this work, we report the observation of polarized upconversion emissions from β-NaYF4 single nanostructures below 100 nm. At the sub-100 nm scale, nanorods, nanodiscs, and nanoplates exhibit distinctive polarization degrees despite the same doping concentrations of lanthanides. We find this varied polarization degree results from the crystallographic orientation of nanostructure in relation to the light field and can be linked to the distinctive emission spectrum profile with varied Stark splitting transition ratios from Er3+. Our findings provide a comprehensive understanding of the polarization properties of upconversion nanoparticles, revealing a previously unexplored aspect of light emission. This discovery expands our knowledge of upconversion nanoparticles and also opens new possibilities for their use in future imaging and sensing applications, where polarization sensitivity is crucial.
Camaya, I, Hill, M, Sais, D, Tran, N, O’Brien, B & Donnelly, S 2024, 'The Parasite‐Derived Peptide, FhHDM‐1, Selectively Modulates miRNA Expression in β‐Cells to Prevent Apoptotic Pathways Induced by Proinflammatory Cytokines', Journal of Diabetes Research, vol. 2024, no. 1.
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We have previously identified a parasite‐derived peptide, FhHDM‐1, that prevented the progression of diabetes in nonobese diabetic (NOD) mice. Disease prevention was mediated by the activation of the PI3K/Akt pathway to promote β‐cell survival and metabolism without inducing proliferation. To determine the molecular mechanisms driving the antidiabetogenic effects of FhHDM‐1, miRNA:mRNA interactions and in silico predictions of the gene networks were characterised in β‐cells, which were exposed to the proinflammatory cytokines that mediate β‐cell destruction in Type 1 diabetes (T1D), in the presence and absence of FhHDM‐1. The predicted gene targets of miRNAs differentially regulated by FhHDM‐1 mapped to the biological pathways that regulate β‐cell biology. Six miRNAs were identified as important nodes in the regulation of PI3K/Akt signaling. Additionally, IGF‐2 was identified as a miRNA gene target that mediated the beneficial effects of FhHDM‐1 on β‐cells. The findings provide a putative mechanism by which FhHDM‐1 positively impacts β‐cells to permanently prevent diabetes. As β‐cell death/dysfunction underlies diabetes development, FhHDM‐1 opens new therapeutic avenues.
Camp, EF, Braverman, I, Wilkinson, G & Voolstra, CR 2024, 'Coral reef protection is fundamental to human rights', Global Change Biology, vol. 30, no. 9.
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AbstractThe intensifying loss of coral reefs from global climate change and local stressors has seen international commitments targeted at conservation and repair, for example the Kunming–Montreal Global Biodiversity Framework. Fulfilling these targets requires decisions to be made on where, when, and how to act, ultimately dictating where limited resources will be deployed. Every choice on action or inaction toward our ocean has direct and indivisible consequences not only for the health of marine ecosystems but also for the health of humans, particularly those who directly depend on marine habitats, both culturally and economically. The well‐being of the environment, humans, and animals is interlinked, co‐dependent, and even co‐produced, as has already been acknowledged by One Health approaches, which endorse a cross‐ and trans‐disciplinary view to health. Coral reefs epitomise how tightly intertwined ecosystem health and the fate of the human and nonhuman communities that depend on them are. A field that thus far remains poorly considered is a human rights‐based approach to coral reef protection. A human rights‐based approach implements human rights obligations, including the recently affirmed right to a clean, healthy, and sustainable environment, while embedding principles of accountability, nondiscrimination, participation, and empowerment for local and Indigenous communities that ensure effectiveness and meaningful stakeholder engagement. Tying the protection of coral reef ecosystems to human rights emphasises the importance of healthy ecosystems to human well‐being and thus the inevitable connection between nonhuman and human life. The general failure to consider coral reef protection through a human rights‐based approach is a missed opportunity to expedite reef protection while simultaneously advancing climate justice for both humans and nonhumans.
Canfield, PJ, Reimers, JR & Crossley, MJ 2024, '“Polytopal Rearrangement Model of Stereoisomerization” and Its Potential as the Basis for a Systematic Model of All Stereoisomerism', ACS Organic & Inorganic Au, vol. 4, no. 4, pp. 356-372.
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Carr, LM, Mustafa, S, Care, A & Collins-Praino, LE 2024, 'More than a number: Incorporating the aged phenotype to improve in vitro and in vivo modeling of neurodegenerative disease', Brain, Behavior, and Immunity, vol. 119, pp. 554-571.
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Carter, DJ, Rahmani, A, Evans, R, Stratigos, A & Brown, J 2024, 'HIV-related Legal Needs, Demographic Change, and Trends in Australia since 1992: A Review of Legal Administrative Data', AIDS and Behavior, vol. 28, no. 2, pp. 574-582.
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Chang, C, Li, X, Duanmu, L, Sun, B & Ju, H 2024, 'Analysis of the impact of indoor thermal comfort data characteristics on dataset quality', Energy and Buildings, vol. 310, pp. 114079-114079.
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Chang, JJ-Y, Grimley, SL, Tran, BM, Deliyannis, G, Tumpach, C, Nguyen, ANT, Steinig, E, Zhang, J, Schröder, J, Caly, L, McAuley, J, Wong, SL, Waters, SA, Stinear, TP, Pitt, ME, Purcell, D, Vincan, E & Coin, LJM 2024, 'Uncovering strain- and age-dependent innate immune responses to SARS-CoV-2 infection in air-liquid-interface cultured nasal epithelia', iScience, vol. 27, no. 6, pp. 110009-110009.
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Chang, Z, Liu, W, Feng, J, Lin, Z, Shi, C, Wang, T, Lei, Y, Zhao, X, Song, J & Wang, G 2024, 'Cobalt/MXene‐derived TiO2 Heterostructure as a Functional Separator Coating to Trap Polysulfide and Accelerate Redox Kinetics for Reliable Lithium‐sulfur Battery', Batteries & Supercaps, vol. 7, no. 4.
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AbstractLithium‐sulfur (Li−S) batteries are one of the most potential new energy storage systems due to their high theoretical capacity (1675 mAh g−1) and high energy density (2600 Wh kg−1). However, the application of Li−S batteries is currently restricted due to the dissolution of polysulfides in the electrolyte, which leads to the shuttle effect of lithium polysulfides (LiPSs). Here, we present a Co@MXene‐derived TiO2 heterostructure decorated on carbon sheets derived from folic acid (Co@M‐TiO2/C) as a functional separator coating to trap polysulfide and accelerate redox kinetics in Li−S batteries. The interconnected porous structure with good electrical conductivity of the heterostructure boasts rapid ion diffusion and efficient electron transfer within the battery. By attaching Co and MXene‐derived dual‐phased TiO2 to two‐dimensional carbon sheets, heterostructures are formed, ensuring complete exposure of the active sites. These heterostructures exhibit catalytic effects on LiPSs and excellent adsorption capabilities, effectively inhibiting the shuttle effect and accelerating the redox kinetics. Considering these advantages, the Li−S battery with the optimized Co@M‐TiO2/C modified separator demonstrates a high specific capacity of 1481.7 mAh g−1 at 0.2 C, superior rate performance of 855.5 mAh g−1 at 2 C, and excellent cycling performance under a high sulfur load of 4.4 mg cm−2.
Chen, J, Li, M, Sun, R, Xie, Y, Reimers, JR & Sun, L 2024, 'Enhancement of Luminescence from Lanthanide Metal–Organic Frameworks by Ytterbium and Calcium Doping: Application to Photonic Barcodes and Fingerprint Detection', Advanced Functional Materials, vol. 34, no. 27.
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AbstractEmission from metal–organic frameworks (MOFs) made from Eu3+ and 1,3,5‐benzenetricarboxylic acid (BTC) is enhanced eightfold by doping with Y3+ and Ca2+ ions. The Ca2+ ions are shown to substitute into the MOFs, and the MOFs structure is shown to be retained at high Y3+ doping levels. The emission enhancement is shown to be associated with variations in the local electric field at the Eu3+ centers in the MOFs. Calculations indicate that the HOMO and LUMO levels vary considerably with both Y3+ doping and with low‐level Ca2+ doping. These then modulates Eu3+ concentration quenching, ligand‐metal energy transfer processes, and the local electric field at the Eu3+ centers, qualitatively accounting for the primary observed features. For UV excitation (250, 295, and 393 nm, respectively), the greatest emission enhancement comes from the doped MOFs with 10% Eu3+, 89% Y3+, and 1% Ca2+. In a photonic barcode application, the doped MOFs are shown to facilitate increased information storage density, and in a fingerprinting application, they are displayed to lead to higher photostability and reduced materials demand.
Chen, J, Zhang, G, Xiao, J, Li, J, Xiao, Y, Zhang, D, Gao, H, Guo, X, Wang, G & Liu, H 2024, 'A Stress Self‐Adaptive Bimetallic Stellar Nanosphere for High‐Energy Sodium‐Ion Batteries', Advanced Functional Materials, vol. 34, no. 1.
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AbstractBimetallic composites exhibit great potential as anode materials in advanced energy storage systems owing to their inherent tunability, cost‐effectiveness, and simultaneous achievement of high specific capacity and low reaction potential. However, simple biphase mixing often fails to achieve satisfactory performance. Herein, an innovative stress self‐adaptive bimetallic stellar nanosphere (50–200 nm) wherein bismuth (Bi) is fabricated, as a core, is seamlessly encapsulated by a tin (Sn) sneath (Sn‐Bi@C). This well‐integrated stellar configuration with bimetallic nature embodies the synergy between Bi and Sn, offering fortified conductivity and heightened sodium ion diffusion kinetics. Moreover, through meticulous utilization of finite element analysis simulations, a homogeneous stress distribution within the Sn‐enveloped Bi, efficiently mitigating the structural strain raised from the insertion of Na+ ions, is uncovered. The corresponding electrode demonstrates remarkable cyclic stability, as it exhibits no capacity decay after 100 cycles at 0.1 A g−1. Furthermore, it achieves an impressive 86.9% capacity retention even after an extensive 2000 cycles. When employed in a Na3V2(PO4)3 ‖ Sn‐Bi@C full cell configuration, it demonstrates exceptional capacity retention of 97.06% after 300 cycles at 1 A g−1, along with a high energy density of 251.2 W h kg−1.
Chen, X, Yang, H, Gu, Y, Wen, C, Sun, Y, Ke, J & Feng, W 2024, 'Interparticle energy transfer between NaNdF4 and NaYbF4 in self-assembled nanostructures', Journal of Rare Earths, vol. 42, no. 6, pp. 1029-1035.
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Chen, Y, Huang, L, Zhou, D, Gao, X, Hu, T, Zhang, Z, Zhen, Z, Chen, X, Cui, L & Wang, G 2024, 'Elucidating and Minimizing the Space‐Charge Layer Effect between NCM Cathode and Li6PS5Cl for Sulfide‐Based Solid‐State Lithium Batteries', Advanced Energy Materials, vol. 14, no. 30.
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AbstractThe electrochemical performance of all‐solid‐state lithium batteries (ASSLBs) can be significantly improved by addressing the challenges posed by space charge layer (SCL) effect, which plays a crucial role in determining Li+ ions transport kinetic at cathodic interface. Therefore, it is critical to realize the in situ inspection and visualization of SCL behaviors for solving sluggish Li+ ions transport issues, despite remaining grant challenges. Therewith, the well‐defined model of LiNbO3‐coated NCM (NCM@LNO) cathode is constructed and assembled for the representative Li6PS5Cl‐based ASSLBs, which not only ensures excellent cathodic compatibility, but also preferably enables the better monitoring of Li+ ions transport kinetics. Combining ex situ analysis with DFT calculation, the formation and evolution mechanism of SCL are comprehensively understood, and the relationship between well‐controlled SCL configuration and Li+ electrochemical behavior has been also further illustrated and established through the operando Raman spectroscopy. On these grounds, the preferred NCM@LNO cathodes acquire the enhanced discharge capacity of 90.6% (144.8 mAh g−1) after 100 cycles and it can still deliver the exceptional capacity of 136.2 mAh g−1 after 800 cycles in ASSLBs. Hence, the research will pave up a new perspective for fundamental scientific insight of the SCL and reasonable tailoring of cathodic interface for high‐efficiency ASSLBs.
Chen, Y, Huang, X, Chen, H & Yi, C 2024, 'An easy-to-perform method for microvessel isolation and primary brain endothelial cell culture to study Alzheimer's disease', Heliyon, vol. 10, no. 12, pp. e33077-e33077.
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Chen, Y, Wang, C, Wu, Y, Wang, Y, Meng, Y, Wu, F, Zhang, H, Cheng, YY, Jiang, X, Shi, J, Li, H, Zhao, P, Wu, J, Zheng, B, Jin, D & Bu, W 2024, 'Nutrient-delivery and metabolism reactivation therapy for melanoma', Nature Nanotechnology, vol. 19, no. 9, pp. 1399-1408.
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Chen, Y, Xu, L, Yang, X, Li, Q, Yao, M & Wang, G 2024, 'Nanocomposite design for solid-state lithium metal batteries: Progress, challenge, and prospects', Advanced Nanocomposites, vol. 1, no. 1, pp. 120-143.
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Chen, Z, Han, G-F, Mahmood, A, Hou, J, Wei, W, Kyong Shon, H, Wang, G, David Waite, T, Baek, J-B & Ni, B-J 2024, 'Mechanosynthesized electroactive materials for sustainable energy and environmental applications: A critical review', Progress in Materials Science, vol. 145, pp. 101299-101299.
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Chen, Z, Zhao, S, Dong, C, Wang, S, Guo, Y, Gao, X, Sun, B, Chen, W & Guo, C 2024, 'Three-stage numerical simulation of tunnel blasting dust diffusion based on field monitoring and CFD', Tunnelling and Underground Space Technology, vol. 150, pp. 105830-105830.
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Chhor, M, Barman, S, Heidari, F, Bottomley, A, Alqudah, A, Grieve, D, Robson, T, McGrath, K & McClements, L 2024, 'Emerging Role of FK506-Binding-Protein-Like (FKBPL) in a New 3D Bioprinted Model of Cardiac Fibrosis', Heart, Lung and Circulation, vol. 33, pp. S476-S476.
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Choi, V, Park, SB, Lacey, J, Kumar, S, Heller, G & Grimison, P 2024, 'Electroacupuncture use for treatment of taxane-induced peripheral neuropathy in patients with breast cancer: protocol for a pilot, randomised, blinded, sham-controlled trial (EA for CIPN)', BMJ Open, vol. 14, no. 1, pp. e076391-e076391.
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IntroductionChemotherapy-induced peripheral neuropathy (CIPN) is a common dose-limiting side effect of neurotoxic chemotherapy. Acute symptoms of CIPN during treatment can lead to dose reduction and cessation. Trials using electroacupuncture (EA) to treat established CIPN postchemotherapy have shown some efficacy. The current trial aims to assess the feasibility and preliminary efficacy of using EA to treat CIPN during chemotherapy.Methods and analysisThe current study is a single-centre, 1:1 randomised, sham-controlled pilot study set in a tertiary cancer hospital in Sydney, Australia, and will recruit 40 adult patients with early breast cancer undergoing adjuvant or neoadjuvant paclitaxel chemotherapy. Patients who develop CIPN within the first 6 weeks of chemotherapy will receive either true EA or sham-EA once a week for 10 weeks. The coprimary endpoints are recruitment and adherence rate, successful blinding of patients and compliance with the follow-up period. Secondary endpoints are mean change of CIPN symptoms from randomisation to end of treatment, sustained change in CIPN symptoms at 8-week and 24-week follow-up postchemotherapy, proportion of subjects attaining completion of 12 weeks of chemotherapy without dose reduction or cessation, change in acupuncture expectancy response pretreatment, during treatment and posttreatment. The primary assessment tool for the secondary endpoints will be a validated patient-reported outcome measure (European Organisation for Research and Treatment of Cancer Quality of Life Chemotherapy-Induced Peripheral Neuropathy) captured weekly from randomisation to week 12 of chemotherapy.Ethics and disseminationThe study protocol (2021/ETH12123) has been approved by the institutional Human Research Ethics Committee at St Vincent’s Hospital Sydney and Chr...
Chowdhury, S, Sais, D, Donnelly, S & Tran, N 2024, 'The knowns and unknowns of helminth–host miRNA cross-kingdom communication', Trends in Parasitology, vol. 40, no. 2, pp. 176-191.
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Ciobanu, LG, Baryshnikova, NV, Jawahar, MC, Toben, CG, Sokolenko, E, Arnet, VK, Addo, IY, Adegboye, OA, Ahinkorah, BO, Alam, K, Alif, SM, Ameyaw, EK, Anderlini, D, Angell, B, Ansar, A, Anyasodor, AE, Astell-Burt, T, Atorkey, P, Ayala Quintanilla, BP, Ayano, G, Babu, AS, Bagheri, N, Baune, BT, Bhandari, D, Bhaskar, S, Boufous, S, Briggs, AM, Bulamu, NB, Burns, RA, Carvalho, AF, Cerin, E, Cherbuin, N, Chowdhury, EK, Cross, M, De Leo, D, Driscoll, TR, Du, M, Edvardsson, D, Edvardsson, K, Efendi, F, Endalamaw, A, Fauk, NK, Flavel, J, Franklin, RC, Gill, TK, Gupta, B, Gupta, VK, Hamiduzzaman, M, Hankey, GJ, Hay, SI, Hebert, JJ, Hendrie, D, Hill, CL, Huda, MM, Shariful Islam, SM, Kaambwa, B, Kandel, H, Kassie, GM, Kerr, JA, Khan, A, Khan, MN, Kulkarni, V, Lalloo, R, Dao Le, LK, Leigh, J, Liu, G, Mahumud, RA, Mamun, AA, McGrath, JJ, Meretoja, A, Miller, TR, Mitchell, PB, Mokdad, AH, Morawska, L, Obamiro, KO, Peden, AE, Pesudovs, K, Rahman, A, Rahman, MM, Rahman, MA, Ratan, ZA, Rawal, L, Rumisha, SF, Sachdev, PS, Seidu, A-A, Sharma, S, Shorofi, SA, Siabani, S, Singh, A, Singh, BB, Slater, H, Stokes, MA, Subedi, N, Tadakamadla, SK, Thrift, AG, Ngoc Tran, MT, Vandelanotte, C, Wang, N, Ward, P, Woodward, M, Xu, X, Yadav, L, Zaman, SB, Zhang, J & Clark, SR 2024, 'Pre-COVID life expectancy, mortality, and burden of diseases for adults 70 years and older in Australia: a systematic analysis for the Global Burden of Disease 2019 Study', The Lancet Regional Health - Western Pacific, vol. 47, pp. 101092-101092.
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Clark, K, Boland, JW & Currow, DC 2024, 'Letter to the Editor. A Response to: Palliative Management of Inoperable Malignant Bowel Obstruction: Prospective, Open Label, Phase 2 Study at an NCI Comprehensive Cancer Center.', Journal of pain and symptom management, vol. 67, no. 6, pp. e919-e920.
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Clover Ree, L, de la Hunty, M, Moret, S & Chadwick, S 2024, 'An investigation into the effect of surfactants on iron oxide powder suspension formulations for fingermark development', Forensic Science International, vol. 358, pp. 112019-112019.
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Cook, AM, Rezende, EL, Petrou, K & Leigh, A 2024, 'Beyond a single temperature threshold: Applying a cumulative thermal stress framework to plant heat tolerance', Ecology Letters, vol. 27, no. 3.
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AbstractMost plant thermal tolerance studies focus on single critical thresholds, which limit the capacity to generalise across studies and predict heat stress under natural conditions. In animals and microbes, thermal tolerance landscapes describe the more realistic, cumulative effects of temperature. We tested this in plants by measuring the decline in leaf photosynthetic efficiency (FV/FM) following a combination of temperatures and exposure times and then modelled these physiological indices alongside recorded environmental temperatures. We demonstrate that a general relationship between stressful temperatures and exposure durations can be effectively employed to quantify and compare heat tolerance within and across plant species and over time. Importantly, we show how FV/FM curves translate to plants under natural conditions, suggesting that environmental temperatures often impair photosynthetic function. Our findings provide more robust descriptors of heat tolerance in plants and suggest that heat tolerance in disparate groups of organisms can be studied with a single predictive framework.
Corletto, A, Fronzi, M, Joannidis, AK, Sherrell, PC, Ford, MJ, Winkler, DA, Shapter, JG, Bullock, J & Ellis, AV 2024, 'A Predictive Model for Monolayer‐Selective Metal‐Mediated MoS2 Exfoliation Incorporating Electrostatics', Advanced Materials Interfaces, vol. 11, no. 2.
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AbstractThe metal‐mediated exfoliation (MME) method enables monolayer‐selective exfoliation of van der Waals (vdW) crystals, improving the efficacy of large monolayer production. Previous physical models explaining monolayer‐selective MME propose that the main contributors to monolayer‐selectivity are vdW crystal/metal surface binding energy and/or vdW crystal layer strain resulting from lattice mismatch. However, the performance of some metals for MME is inconsistent with these models. Here, a new model is proposed using MoS2 as a representative vdW crystal. The model explains how the MoS2/metal interface electrostatics, in combination with strain, determines monolayer‐selectivity of MME by modulating the MoS2 interlayer energy. Monolayer MoS2/metal interfaces are characterized using in situ Raman spectroscopy and density functional theory calculations to estimate the electrostatics and strain of MoS2 in contact with different metals. The model successfully demonstrates the dependence of MME monolayer‐selectivity on the MoS2/metal interface electrostatics and highlights the significance of electrostatics in nanomaterial vdW interactions.
Corrie, L, Singh, H, Gulati, M, Vishwas, S, Chellappan, DK, Gupta, G, Paiva-Santos, AC, Veiga, F, Alotaibi, F, Alam, A, Eri, RD, Prasher, P, Adams, J, Paudel, KR, Dua, K & Singh, SK 2024, 'Polysaccharide-fecal microbiota-based colon-targeted self-nanoemulsifying drug delivery system of curcumin for treating polycystic ovarian syndrome', Naunyn-Schmiedeberg's Archives of Pharmacology, vol. 397, no. 9, pp. 6721-6743.
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Cotter, DJ, Severson, AL, Kang, JTL, Godrej, HN, Carmi, S & Rosenberg, NA 2024, 'Modeling the effects of consanguinity on autosomal and X-chromosomal runs of homozygosity and identity-by-descent sharing', G3: Genes, Genomes, Genetics, vol. 14, no. 2.
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Abstract Runs of homozygosity (ROH) and identity-by-descent (IBD) sharing can be studied in diploid coalescent models by noting that ROH and IBD-sharing at a genomic site are predicted to be inversely related to coalescence times—which in turn can be mathematically obtained in terms of parameters describing consanguinity rates. Comparing autosomal and X-chromosomal coalescent models, we consider ROH and IBD-sharing in relation to consanguinity that proceeds via multiple forms of first-cousin mating. We predict that across populations with different levels of consanguinity, (1) in a manner that is qualitatively parallel to the increase of autosomal IBD-sharing with autosomal ROH, X-chromosomal IBD-sharing increases with X-chromosomal ROH, owing to the dependence of both quantities on consanguinity levels; (2) even in the absence of consanguinity, X-chromosomal ROH and IBD-sharing levels exceed corresponding values for the autosomes, owing to the smaller population size and lower coalescence time for the X chromosome than for autosomes; (3) with matrilateral consanguinity, the relative increase in ROH and IBD-sharing on the X chromosome compared to the autosomes is greater than in the absence of consanguinity. Examining genome-wide SNPs in human populations for which consanguinity levels have been estimated, we find that autosomal and X-chromosomal ROH and IBD-sharing levels generally accord with the predictions. We find that each 1% increase in autosomal ROH is associated with an increase of 2.1% in X-chromosomal ROH, and each 1% increase in autosomal IBD-sharing is associated with an increase of 1.6% in X-chromosomal IBD-sharing. For each calculation, particularly for ROH, the estimate is reasonably close to the increase of 2% predicted by the population-size difference between autosomes and X chromosomes. The results support the utility of coalescent models for understanding patterns of genomic sharing an...
Cruickshank, MM, Moles, AT, Debono, SA & Xirocostas, ZA 2024, 'COVERater—A Free Application for Training Researchers to Accurately Estimate Species Cover in Terrestrial and Aquatic Ecosystems', Ecology and Evolution, vol. 14, no. 10.
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ABSTRACTVisual estimates of cover are widely used among ecologists, from describing vegetation communities to tracking and monitoring species' abundance. However, despite the known bias associated with visual estimates, no standardised training is available to improve these measurements. We developed a free online training tool, the COVERater, that effectively teaches users to visually estimate the percent cover of species in a variety of ecosystems (including alpine heath, arid lands, coral reefs, temperate reefs and wetlands). Prior to training, users with prior professional experience estimated species cover to an average inaccuracy of 5.2%, while users with no experience estimated cover to an average inaccuracy of 7.6%. COVERater training took an average of 31 min and 68 images, and reduced the estimate inaccuracy of users with no prior experience to 5.2%. There was no significant loss of estimate accuracy over 100 days following training. The COVERater can be used anywhere in the world, by data collectors of all experience levels, for projects spanning all spatial scales. By providing researchers with standardised training, our application can reduce variation in cover estimates that arise from human biases, allowing for comparable estimates across global collaborative projects and data syntheses. We encourage all relevant scientists to include COVERater training in their protocols to quantify cover with greater accuracy, improve the veracity of their results and make better inferences about our biosphere.
D’Amato, ME, Joly, Y, Lynch, V, Machado, H, Scudder, N & Zieger, M 2024, 'Ethical considerations for Forensic Genetic Frequency databases: First Report conception and development', Forensic Science International: Genetics, vol. 71, pp. 103053-103053.
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d’Antonio, D, Bell, ME, Brown, JJ & Grazian, C 2024, 'State Space Modelling for detecting and characterising gravitational waves afterglows', Astronomy and Computing, vol. 48, pp. 100860-100860.
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Daniel, R, Raymond, J, Sears, A, Stock, A, Scudder, N, Padmabandu, G, Kumar, SA, Snedecor, J, Antunes, J & Hartman, D 2024, 'It’s all relative: A multi-generational study using ForenSeq™ Kintelligence', Forensic Science International, vol. 364, pp. 112208-112208.
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Datsyuk, JK, De Rubis, G, Paudel, KR, Kokkinis, S, Oliver, BGG & Dua, K 2024, 'Cellular probing using phytoceuticals encapsulated advanced delivery systems in ameliorating lung diseases: Current trends and future prospects', International Immunopharmacology, vol. 141, pp. 112913-112913.
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Dawson, BM, Ueland, M, Carter, DO, Mclntyre, D & Barton, PS 2024, 'Bridging the gap between decomposition theory and forensic research on postmortem interval', International Journal of Legal Medicine, vol. 138, no. 2, pp. 509-518.
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AbstractKnowledge of the decomposition of vertebrate animals has advanced considerably in recent years and revealed complex interactions among biological and environmental factors that affect rates of decay. Yet this complexity remains to be fully incorporated into research or models of the postmortem interval (PMI). We suggest there is both opportunity and a need to use recent advances in decomposition theory to guide forensic research and its applications to understanding the PMI. Here we synthesise knowledge of the biological and environmental factors driving variation in decomposition and the acknowledged limitations among current models of the PMI. To guide improvement in this area, we introduce a conceptual framework that highlights the multiple interdependencies affecting decay rates throughout the decomposition process. Our framework reinforces the need for a multidisciplinary approach to PMI research, and calls for an adaptive research cycle that aims to reduce uncertainty in PMI estimates via experimentation, modelling, and validation.
De Rubis, G, Chakraborty, A, Paudel, KR, Wang, C, Kannaujiya, V, Wich, PR, Hansbro, PM, Samuel, CS, Oliver, B & Dua, K 2024, 'Exploring the anti-inflammatory and anti-fibrotic activity of NFκB decoy oligodeoxynucleotide-loaded spermine-functionalized acetalated nanoparticles', Chemico-Biological Interactions, vol. 396, pp. 111059-111059.
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De Rubis, G, Paudel, KR, Allam, VSRR, Malyla, V, Subramaniyan, V, Singh, SK, Panth, N, Gupta, G, Hansbro, PM, Chellappan, DK & Dua, K 2024, 'Involvement of osteopontin, EpCAM, estrogen receptor-alpha, and carbonic anhydrase IX protein in managing lung cancer via Berberine-loaded liquid crystalline nanoparticles', Pathology - Research and Practice, vol. 253, pp. 154971-154971.
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De Rubis, G, Paudel, KR, Corrie, L, Mehndiratta, S, Patel, VK, Kumbhar, PS, Manjappa, AS, Disouza, J, Patravale, V, Gupta, G, Manandhar, B, Rajput, R, Robinson, AK, Reyes, R-J, Chakraborty, A, Chellappan, DK, Singh, SK, Oliver, BGG, Hansbro, PM & Dua, K 2024, 'Applications and advancements of nanoparticle-based drug delivery in alleviating lung cancer and chronic obstructive pulmonary disease', Naunyn-Schmiedeberg's Archives of Pharmacology, vol. 397, no. 5, pp. 2793-2833.
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Lung cancer (LC) and chronic obstructive pulmonary disease (COPD) are among the leading causes of mortality worldwide. Cigarette smoking is among the main aetiologic factors for both ailments. These diseases share common pathogenetic mechanisms including inflammation, oxidative stress, and tissue remodelling. Current therapeutic approaches are limited by low efficacy and adverse effects. Consequentially, LC has a 5-year survival of < 20%, while COPD is incurable, underlining the necessity for innovative treatment strategies. Two promising emerging classes of therapy against these diseases include plant-derived molecules (phytoceuticals) and nucleic acid-based therapies. The clinical application of both is limited by issues including poor solubility, poor permeability, and, in the case of nucleic acids, susceptibility to enzymatic degradation, large size, and electrostatic charge density. Nanoparticle-based advanced drug delivery systems are currently being explored as flexible systems allowing to overcome these limitations. In this review, an updated summary of the most recent studies using nanoparticle-based advanced drug delivery systems to improve the delivery of nucleic acids and phytoceuticals for the treatment of LC and COPD is provided. This review highlights the enormous relevance of these delivery systems as tools that are set to facilitate the clinical application of novel categories of therapeutics with poor pharmacokinetic properties. This picture was generated with BioRender.
De Rubis, G, Paudel, KR, Vishwas, S, Kokkinis, S, Chellappan, DK, Gupta, G, MacLoughlin, R, Gulati, M, Singh, SK & Dua, K 2024, 'Fecal microbiome extract downregulates the expression of key proteins at the interface between airway remodelling and lung cancer pathogenesis in vitro', Pathology - Research and Practice, vol. 260, pp. 155387-155387.
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De Rubis, G, Paudel, KR, Yeung, S, Agarwal, V, Hansbro, PM, Oliver, BGG & Dua, K 2024, 'Ribavirin attenuates carcinogenesis by downregulating IL-6 and IL-8 in vitro in human lung adenocarcinoma', Pathology - Research and Practice, vol. 253, pp. 155038-155038.
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De Rubis, G, Paudel, KR, Yeung, S, Mohamad, S, Sudhakar, S, Singh, SK, Gupta, G, Hansbro, PM, Chellappan, DK, Oliver, BGG & Dua, K 2024, '18-β-glycyrrhetinic acid-loaded polymeric nanoparticles attenuate cigarette smoke-induced markers of impaired antiviral response in vitro', Pathology - Research and Practice, vol. 257, pp. 155295-155295.
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Denis, V, Ferrier‐Pagès, C, Schubert, N, Coppari, M, Baker, DM, Camp, EF, Gori, A, Grottoli, AG, Houlbrèque, F, Maier, SR, Mancinelli, G, Martinez, S, Yalçın Özdilek, Ş, Radice, VZ, Ribes, M, Richter, C, Viladrich, N & Rossi, S 2024, 'Heterotrophy in marine animal forests in an era of climate change', Biological Reviews, vol. 99, no. 3, pp. 965-978.
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ABSTRACTMarine animal forests (MAFs) are benthic ecosystems characterised by biogenic three‐dimensional structures formed by suspension feeders such as corals, gorgonians, sponges and bivalves. They comprise highly diversified communities among the most productive in the world's oceans. However, MAFs are in decline due to global and local stressors that threaten the survival and growth of their foundational species and associated biodiversity. Innovative and scalable interventions are needed to address the degradation of MAFs and increase their resilience under global change. Surprisingly, few studies have considered trophic interactions and heterotrophic feeding of MAF suspension feeders as an integral component of MAF conservation. Yet, trophic interactions are important for nutrient cycling, energy flow within the food web, biodiversity, carbon sequestration, and MAF stability. This comprehensive review describes trophic interactions at all levels of ecological organisation in tropical, temperate, and cold‐water MAFs. It examines the strengths and weaknesses of available tools for estimating the heterotrophic capacities of the foundational species in MAFs. It then discusses the threats that climate change poses to heterotrophic processes. Finally, it presents strategies for improving trophic interactions and heterotrophy, which can help to maintain the health and resilience of MAFs.
Devlin, C, Chadwick, S, Moret, S, Baechler, S, Rossy, Q & Morelato, M 2024, 'Illuminating the dark web market of fraudulent identity documents and personal information: An international and Australian perspective', Forensic Science International, vol. 363, pp. 112203-112203.
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Devlin, C, Morelato, M & Baechler, S 2024, 'Forensic intelligence: Expanding the potential of forensic document examination', WIREs Forensic Science, vol. 6, no. 5.
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AbstractForensic document examination is characterized by its longevity, diversity, and evolution over time. Predominantly, published research within this field has focused on handwriting examination, the articulation of forensic conclusions, and the development of technical instrumental advancements, focusing on the use of document examination in the resolution of casework. This is a persistent and common problem within forensic science that Kirk identified in 1963 and that other authors have reaffirmed more recently. Ultimately, this has resulted in the potential of forensic intelligence, remaining relatively underexplored in the field of document examination. Forensic intelligence is a different way to view and analyze traces, shifting the focus from the traditional identification of source and activity, to instead identifying trends in criminal activity to assist in the reduction, prevention, and proactive disruption of crime. Despite a distinct disparity between these strands of research, there has been a persevering evolution toward the implementation of a systematic forensic intelligence method for the examination of fraudulent identity documents. Since its initial inception into the research community, this method has expanded and been implemented across Europe, and Canada, with tests also being conducted in Australia. These first tangible steps toward a forensic intelligence capacity within document examination have also inspired new work using forensic intelligence and systematic comparisons within the field of handwriting examination, as well as the recognition of the transversal potential of this method, with it being applied to both physical and digital documents. In this review, the fields of document examination and forensic intelligence will first be introduced, along with a subsequent examination of the research that has led to the creation of a forensic intelligence model within the field of document ex...
DiBattista, JD, Fowler, AM, Shalders, TC, Williams, RJ & Wilkinson, S 2024, 'Tree of life metabarcoding can serve as a biotic benchmark for shifting baselines in urbanized estuaries', Environmental Research, vol. 258, pp. 119454-119454.
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Dilernia, NJ, Woodcock, S, Camp, EF, Hughes, DJ, Kühl, M & Suggett, DJ 2024, 'Intra‐colony spatial variance of oxyregulation and hypoxic thresholds for key Acropora coral species', Ecology and Evolution, vol. 14, no. 3, p. e11100.
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AbstractOxygen (O2) availability is essential for healthy coral reef functioning, yet how continued loss of dissolved O2 via ocean deoxygenation impacts performance of reef building corals remains unclear. Here, we examine how intra‐colony spatial geometry of important Great Barrier Reef (GBR) coral species Acropora may influence variation in hypoxic thresholds for upregulation, to better understand capacity to tolerate future reductions in O2 availability. We first evaluate the application of more streamlined models used to parameterise Hypoxia Response Curve data, models that have been used historically to identify variable oxyregulatory capacity. Using closed‐system respirometry to analyse O2 drawdown rate, we show that a two‐parameter model returns similar outputs as previous 12th‐order models for descriptive statistics such as the average oxyregulation capacity (Tpos) and the ambient O2 level at which the coral exerts maximum regulation effort (Pcmax), for diverse Acropora species. Following an experiment to evaluate whether stress induced by coral fragmentation for respirometry affected O2 drawdown rate, we subsequently identify differences in hypoxic response for the interior and exterior colony locations for the species Acropora abrotanoides, Acropora cf. microphthalma and Acropora elseyi. Average regulation capacity across species was greater (0.78–1.03 ± SE 0.08) at the colony interior compared with exterior (0.60–0.85 ± SE 0.08). Moreover, Pcmax occurred at relatively low pO2 of <30% (±1.24; SE) air saturation for a...
Ding, L, Chen, C, Shan, X, Liu, B, Wang, D, Du, Z, Zhao, G, Su, QP, Yang, Y, Halkon, B, Tran, TT, Liao, J, Aharonovich, I, Zhang, M, Cheng, F, Fu, L, Xu, X & Wang, F 2024, 'Optical Nonlinearity Enabled Super‐Resolved Multiplexing Microscopy', Advanced Materials, vol. 36, no. 2.
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AbstractOptical multiplexing for nanoscale object recognition is of great significance within the intricate domains of biology, medicine, anti‐counterfeiting, and microscopic imaging. Traditionally, the multiplexing dimensions of nanoscopy are limited to emission intensity, color, lifetime, and polarization. Here, a novel dimension, optical nonlinearity, is proposed for super‐resolved multiplexing microscopy. This optical nonlinearity is attributable to the energy transitions between multiple energy levels of the doped lanthanide ions in upconversion nanoparticles (UCNPs), resulting in unique optical fingerprints for UCNPs with different compositions. A vortex beam is applied to transport the optical nonlinearity onto the imaging point‐spread function (PSF), creating a robust super‐resolved multiplexing imaging strategy for differentiating UCNPs with distinctive optical nonlinearities. The composition information of the nanoparticles can be retrieved with variations of the corresponding PSF in the obtained image. Four channels multiplexing super‐resolved imaging with a single scanning, applying emission color and nonlinearity of two orthogonal imaging dimensions with a spatial resolution higher than 150 nm (1/6.5λ), are demonstrated. This work provides a new and orthogonal dimension – optical nonlinearity – to existing multiplexing dimensions, which shows great potential in bioimaging, anti‐counterfeiting, microarray assays, deep tissue multiplexing detection, and high‐density data storage.
Ding, L, Chen, C, Shan, X, Liu, B, Wang, D, Du, Z, Zhao, G, Su, QP, Yang, Y, Halkon, B, Tran, TT, Liao, J, Aharonovich, I, Zhang, M, Cheng, F, Fu, L, Xu, X & Wang, F 2024, 'Optical Nonlinearity Enabled Super‐Resolved Multiplexing Microscopy (Adv. Mater. 2/2024)', Advanced Materials, vol. 36, no. 2.
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Donovan, C, Thorpe, AE, Gomez, HM, Carroll, OR, Feng, M, Bai, X, Chen, H, Horvat, JC, Oliver, BGG & Kim, RY 2024, 'The GPR84 Antagonist GLPG1205 Reduces Features of Disease in Experimental Severe Asthma', American Journal of Respiratory Cell and Molecular Biology, vol. 70, no. 5, pp. 424-427.
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Dooley, AH 2024, 'Gavin Brown: 1942–2010', Historical Records of Australian Science.
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Dougan, KE, Bellantuono, AJ, Kahlke, T, Abbriano, RM, Chen, Y, Shah, S, Granados-Cifuentes, C, van Oppen, MJH, Bhattacharya, D, Suggett, DJ, Rodriguez-Lanetty, M & Chan, CX 2024, 'Whole-genome duplication in an algal symbiont bolsters coral heat tolerance', Science Advances, vol. 10, no. 29.
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The algal endosymbiont Durusdinium trenchii enhances the resilience of coral reefs under thermal stress. D. trenchii can live freely or in endosymbiosis, and the analysis of genetic markers suggests that this species has undergone whole-genome duplication (WGD). However, the evolutionary mechanisms that underpin the thermotolerance of this species are largely unknown. Here, we present genome assemblies for two D. trenchii isolates, confirm WGD in these taxa, and examine how selection has shaped the duplicated genome regions using gene expression data. We assess how the free-living versus endosymbiotic lifestyles have contributed to the retention and divergence of duplicated genes, and how these processes have enhanced the thermotolerance of D. trenchii . Our combined results suggest that lifestyle is the driver of post-WGD evolution in D. trenchii , with the free-living phase being the most important, followed by endosymbiosis. Adaptations to both lifestyles likely enabled D. trenchii to provide enhanced thermal stress protection to the host coral.
Dunbar, A, Drigo, B, Djordjevic, SP, Donner, E & Hoye, BJ 2024, 'Impacts of coprophagic foraging behaviour on the avian gut microbiome', Biological Reviews, vol. 99, no. 2, pp. 582-597.
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ABSTRACTAvian gut microbial communities are complex and play a fundamental role in regulating biological functions within an individual. Although it is well established that diet can influence the structure and composition of the gut microbiota, foraging behaviour may also play a critical, yet unexplored role in shaping the composition, dynamics, and adaptive potential of avian gut microbiota. In this review, we examine the potential influence of coprophagic foraging behaviour on the establishment and adaptability of wild avian gut microbiomes. Coprophagy involves the ingestion of faeces, sourced from either self (autocoprophagy), conspecific animals (allocoprophagy), or heterospecific animals. Much like faecal transplant therapy, coprophagy may (i) support the establishment of the gut microbiota of young precocial species, (ii) directly and indirectly provide nutritional and energetic requirements, and (iii) represent a mechanism by which birds can rapidly adapt the microbiota to changing environments and diets. However, in certain contexts, coprophagy may also pose risks to wild birds, and their microbiomes, through increased exposure to chemical pollutants, pathogenic microbes, and antibiotic‐resistant microbes, with deleterious effects on host health and performance. Given the potentially far‐reaching consequences of coprophagy for avian microbiomes, and the dearth of literature directly investigating these links, we have developed a predictive framework for directing future research to understand better when and why wild birds engage in distinct types of coprophagy, and the consequences of this foraging behaviour. There is a need for comprehensive investigation into the influence of coprophagy on avian gut microbiotas and its effects on host health and performance throughout ontogeny and across a range of environmental perturbations. Fu...
Duncan, RJ, Nielsen, D, Søreide, JE, Varpe, Ø, Tobin, MJ, Pitusi, V, Heraud, P & Petrou, K 2024, 'Biomolecular profiles of Arctic sea-ice diatoms highlight the role of under-ice light in cellular energy allocation', ISME Communications, vol. 4, no. 1.
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Abstract Arctic sea-ice diatoms fuel polar marine food webs as they emerge from winter darkness into spring. Through their photosynthetic activity they manufacture the nutrients and energy that underpin secondary production. Sea-ice diatom abundance and biomolecular composition vary in space and time. With climate change causing short-term extremes and long-term shifts in environmental conditions, understanding how and in what way diatoms adjust biomolecular stores with environmental perturbation is important to gain insight into future ecosystem energy production and nutrient transfer. Using synchrotron-based Fourier transform infrared microspectroscopy, we examined the biomolecular composition of five dominant sea-ice diatom taxa from landfast ice communities covering a range of under-ice light conditions during spring, in Svalbard, Norway. In all five taxa, we saw a doubling of lipid and fatty acid content when light transmitted to the ice–water interface was >5% but <15% (85%–95% attenuation through snow and ice). We determined a threshold around 15% light transmittance after which biomolecular synthesis plateaued, likely because of photoinhibitory effects, except for Navicula spp., which continued to accumulate lipids. Increasing under-ice light availability led to increased energy allocation towards carbohydrates, but this was secondary to lipid synthesis, whereas protein content remained stable. It is predicted that under-ice light availability will change in the Arctic, increasing because of sea-ice thinning and potentially decreasing with higher snowfall. Our findings show that the nutritional content of sea-ice diatoms is taxon-specific and linked to these changes, highlighting potential implications for future energy and nutrient supply for the polar marine food web.
Duncan, RJ, Søreide, JE, Varpe, Ø, Wiktor, J, Pitusi, V, Runge, E & Petrou, K 2024, 'Spatio-temporal dynamics in microalgal communities in Arctic land-fast sea ice', Progress in Oceanography, vol. 224, pp. 103248-103248.
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Eilers, K, Hoong Yam, JK, Liu, X, Goh, YF, To, K-N, Paracuellos, P, Morton, R, Brizuela, J, Hui Yong, AM, Givskov, M, Freibert, S-A, Bange, G, Rice, SA, Steinchen, W & Filloux, A 2024, 'The dual GGDEF/EAL domain enzyme PA0285 is a Pseudomonas species housekeeping phosphodiesterase regulating early attachment and biofilm architecture', Journal of Biological Chemistry, vol. 300, no. 2, pp. 105659-105659.
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El Sherkawi, T, Bani Saeid, A, Yeung, S, Chellappan, DK, Mohamad, S, Kokkinis, S, Sudhakar, S, Singh, SK, Gupta, G, Paudel, KR, Hansbro, PM, Oliver, B, De Rubis, G & Dua, K 2024, 'Therapeutic potential of 18-β-glycyrrhetinic acid-loaded poly (lactic-co-glycolic acid) nanoparticles on cigarette smoke-induced in-vitro model of COPD', Pathology - Research and Practice, vol. 263, pp. 155629-155629.
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Elankumaran, P, Browning, GF, Marenda, MS, Kidsley, A, Osman, M, Haenni, M, Johnson, JR, Trott, DJ, Reid, CJ & Djordjevic, SP 2024, 'Corrigendum: Identification of genes influencing the evolution of Escherichia coli ST372 in dogs and humans', Microbial Genomics, vol. 10, no. 8.
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Ellis, JT & Stothard, JR 2024, 'Celebrating 150 volumes of Parasitology with an outlook towards 2030 production', Parasitology, vol. 151, no. 3, pp. 247-250.
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Espinoza-Corral, R, Iwai, M, Zavřel, T, Lechno-Yossef, S, Sutter, M, Červený, J, Niyogi, KK & Kerfeld, CA 2024, 'Phycobilisome protein ApcG interacts with PSII and regulates energy transfer in Synechocystis', Plant Physiology, vol. 194, no. 3, pp. 1383-1396.
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Abstract Photosynthetic organisms harvest light using pigment–protein complexes. In cyanobacteria, these are water-soluble antennae known as phycobilisomes (PBSs). The light absorbed by PBS is transferred to the photosystems in the thylakoid membrane to drive photosynthesis. The energy transfer between these complexes implies that protein–protein interactions allow the association of PBS with the photosystems. However, the specific proteins involved in the interaction of PBS with the photosystems are not fully characterized. Here, we show in Synechocystis sp. PCC 6803 that the recently discovered PBS linker protein ApcG (sll1873) interacts specifically with PSII through its N-terminal region. Growth of cyanobacteria is impaired in apcG deletion strains under light-limiting conditions. Furthermore, complementation of these strains using a phospho-mimicking version of ApcG causes reduced growth under normal growth conditions. Interestingly, the interaction of ApcG with PSII is affected when a phospho-mimicking version of ApcG is used, targeting the positively charged residues interacting with the thylakoid membrane, suggesting a regulatory role mediated by phosphorylation of ApcG. Low-temperature fluorescence measurements showed decreased PSI fluorescence in apcG deletion and complementation strains. The PSI fluorescence was the lowest in the phospho-mimicking complementation strain, while the pull-down experiment showed no interaction of ApcG with PSI under any tested condition. Our results highlight the importance of ApcG for selectively directing energy harvested by the PBS and imply that the phosphorylation status of ApcG plays a role in regulating energy transfer from PSII to PSI.
Etminaniesfahani, A, Gu, H, Naeni, LM & Salehipour, A 2024, 'An efficient relax-and-solve method for the multi-mode resource constrained project scheduling problem', Annals of Operations Research, vol. 338, no. 1, pp. 41-68.
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Faiz, A, Wiersma, VR, Salzbrunn, JB, Brandsma, C-A, Timens, W, Burgess, JK, van den Berge, M, Slebos, D-J, Guryev, V & Pouwels, SD 2024, 'COPD Patients Display Increased Peripheral Blood Somatic Mutations Which Associate With the Prevalence of Co-morbidities', Archivos de Bronconeumología, vol. 60, no. 2, pp. 119-121.
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Feary, DA, Fowler, AM & Booth, DJ 2024, 'Predator-avoidance behaviour of target and non-target temperate reef fishes is lower in areas protected from fishing', Marine Biology, vol. 171, no. 3.
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AbstractThe effects of hunting on predator-avoidance behaviour are increasingly being recognised on land but have received less attention in marine systems. We examined whether predator-avoidance behaviour of temperate reef fishes differed between areas protected and not protected from recreational fishing by examining the flight-initiation distance (FID; the distance a predator can approach before the prey animal flees) of six common species in southeastern Australia. By testing species that ranged in desirability to recreational fishers, we could determine if behavioural differences were specific to target species or extended more broadly throughout the assemblage. After accounting for potential variability among sites within protection levels, we found that the FID of all species was higher in fished areas than protected areas, with FID up to 2.4 times higher in fished areas. The two commonly targeted species had the greatest FID response to fishing. FID also increased with body size for all but one species. Our findings indicate the potential for assemblage-wide effects of fishing on predator-avoidance behaviour and are consistent with an indirect mechanism of behavioural modification.
Feo, E & Gale, PA 2024, 'Therapeutic synthetic anion transporters', Current Opinion in Chemical Biology, vol. 83, pp. 102535-102535.
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Ferrari, AJ, Santomauro, DF, Aali, A, Abate, YH, Abbafati, C, Abbastabar, H, Abd ElHafeez, S, Abdelmasseh, M, Abd-Elsalam, S, Abdollahi, A, Abdullahi, A, Abegaz, KH, Abeldaño Zuñiga, RA, Aboagye, RG, Abolhassani, H, Abreu, LG, Abualruz, H, Abu-Gharbieh, E, Abu-Rmeileh, NME, Ackerman, IN, Addo, IY, Addolorato, G, Adebiyi, AO, Adepoju, AV, Adewuyi, HO, Afyouni, S, Afzal, S, Afzal, S, Agodi, A, Ahmad, A, Ahmad, D, Ahmad, F, Ahmad, S, Ahmed, A, Ahmed, LA, Ahmed, MB, Ajami, M, Akinosoglou, K, Akkaif, MA, Al Hasan, SM, Alalalmeh, SO, Al-Aly, Z, Albashtawy, M, Aldridge, RW, Alemu, MD, Alemu, YM, Alene, KA, Al-Gheethi, AAS, Alharrasi, M, Alhassan, RK, Ali, MU, Ali, R, Ali, SSS, Alif, SM, Aljunid, SM, Al-Marwani, S, Almazan, JU, Alomari, MA, Al-Omari, B, Altaany, Z, Alvis-Guzman, N, Alvis-Zakzuk, NJ, Alwafi, H, Al-Wardat, MS, Al-Worafi, YM, Aly, S, Alzoubi, KH, Amare, AT, Amegbor, PM, Ameyaw, EK, Amin, TT, Amindarolzarbi, A, Amiri, S, Amugsi, DA, Ancuceanu, R, Anderlini, D, Anderson, DB, Andrade, PP, Andrei, CL, Ansari, H, Antony, CM, Anwar, S, Anwar, SL, Anwer, R, Anyanwu, PE, Arab, JP, Arabloo, J, Arafat, M, Araki, DT, Aravkin, AY, Arkew, M, Armocida, B, Arndt, MB, Arooj, M, Artamonov, AA, Aruleba, RT, Arumugam, A, Ashbaugh, C, Ashemo, MY, Ashraf, M, Asika, MO, Askari, E, Astell-Burt, T, Athari, SS, Atorkey, P, Atout, MMW, Atreya, A, Aujayeb, A, Ausloos, M, Avan, A, Awotidebe, AW, Awuviry-Newton, K, Ayala Quintanilla, BP, Ayuso-Mateos, JL, Azadnajafabad, S, Azevedo, RMS, Babu, AS, Badar, M, Badiye, AD, Baghdadi, S, Bagheri, N, Bah, S, Bai, R, Baker, JL, Bakkannavar, SM, Bako, AT, Balakrishnan, S, Bam, K, Banik, PC, Barchitta, M, Bardhan, M, Bardideh, E, Barker-Collo, SL, Barqawi, HJ, Barrow, A, Barteit, S, Barua, L, Bashiri Aliabadi, S, Basiru, A, Basu, S, Basu, S, Bathini, PP, Batra, K, Baune, BT, Bayileyegn, NS, Behnam, B, Behnoush, AH, Beiranvand, M, Bejarano Ramirez, DF, Bell, ML, Bello, OO, Beloukas, A, Bensenor, IM, Berezvai, Z, Bernabe, E, Bernstein, RS, Bettencourt, PJG, Bhagavathula, AS, Bhala, N, Bhandari, D, Bhargava, A, Bhaskar, S, Bhat, V, Bhatti, GK, Bhatti, JS, Bhatti, MS, Bhatti, R, Bhutta, ZA, Bikbov, B, Bishai, JD, Bisignano, C, Bitra, VR, Bjørge, T, Bodolica, V, Bodunrin, AO, Bogale, EK, Bonakdar Hashemi, M, Bonny, A, Bora Basara, B, Borhany, H, Boxe, C, Brady, OJ, Bragazzi, NL, Braithwaite, D, Brant, LC & et al. 2024, 'Global incidence, prevalence, years lived with disability (YLDs), disability-adjusted life-years (DALYs), and healthy life expectancy (HALE) for 371 diseases and injuries in 204 countries and territories and 811 subnational locations, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021', The Lancet, vol. 403, no. 10440, pp. 2133-2161.
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Field, NR, Dickson, K-A, Nassif, NT & Marsh, DJ 2024, 'SMARCA4 and SMARCA2 co-deficiency: An uncommon molecular signature defining a subset of rare, aggressive and undifferentiated malignancies associated with defective chromatin remodeling', Cancer Letters, vol. 605, pp. 217282-217282.
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Fitschen, LJ, Newing, TP, Johnston, NP, Bell, CE & Tolun, G 2024, 'Half a century after their discovery: Structural insights into exonuclease and annealase proteins catalyzing recombineering', Engineering Microbiology, vol. 4, no. 1, pp. 100120-100120.
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Freedman, LS, Wang, C-Y, Commins, J, Barrett, B, Midthune, D, Dodd, KW, Carroll, RJ & Kipnis, V 2024, 'Can sodium and potassium measured in timed voids be used as reference instruments for validating self-report instruments? Results from a urine calibration study', The American Journal of Clinical Nutrition, vol. 119, no. 5, pp. 1321-1328.
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Fu, Z, Yang, X, Tian, Y, Hu, X, Wang, Y, Lin, L, Kang, F, Wang, G, Li, B & Zhou, D 2024, 'Solvation engineering of non-aqueous electrolytes for room-temperature fluoride-ion batteries', Energy Storage Materials, vol. 70, pp. 103533-103533.
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Fursman, H, Finch, E, Xiao, L, Lefrançois, E, Gupta, A, Bartlett, M, Latimer, J, Chadwick, S, Roux, C & Morelato, M 2024, 'A snapshot of injecting drug consumption from the analysis of used syringes within the Medically Supervised Injecting Centre in Sydney, Australia', Drug and Alcohol Review, vol. 43, no. 3, pp. 787-798.
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AbstractIntroductionThe administration of illicit drugs by injection is associated with considerable harm, including an increased risk of overdose. The chemical analysis of used syringes can enhance knowledge on injecting drug consumption beyond traditional data sources (self‐report surveys). This additional information may be useful during significant global events like the COVID‐19 pandemic. This study aimed to examine a snapshot of the drugs injected at the Medically Supervised Injecting Centre (MSIC) in Sydney, Australia, in 2019–2020.MethodsUsed syringes were collected from MSIC across three periods throughout 2019 and 2020 (February 2019, March—April 2020 and June—September 2020). Drug residues were extracted from used syringes using methanol before detection by gas chromatography—mass spectrometry and ultra‐performance liquid chromatography—tandem mass spectrometry. The chemical analysis results were compared to self‐report data obtained from MSIC clients.ResultsHeroin (46–53%), methamphetamine (24–34%) and pharmaceutical opioids (15–27%) were the most common drug residues detected. The chemically detected drugs had declining coherence with the drugs self‐reported by MSIC clients across the time periods examined.Discussion and ConclusionsThere was no significant change in the drugs injected (heroin, methamphetamine and pharmaceutical opioids) across the three periods collected throughout varying COVID‐19 lockdown restrictions. Changes in the frequency of other drugs injected and discrepancies between chemical analysis and self‐report were potentially related to regulatory changes, degradation or misinformed sales. Routine chemical analysis of used syringes has provided an alternative informatio...
Fursman, H, Morelato, M, Chadwick, S, Coppey, F, Esseiva, P, Roux, C & Stojanovska, N 2024, 'Development and evaluation of portable NIR technology for the identification and quantification of Australian illicit drugs', Forensic Science International, vol. 362, pp. 112179-112179.
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Gadhave, DG, Sugandhi, VV, Jha, SK, Nangare, SN, Gupta, G, Singh, SK, Dua, K, Cho, H, Hansbro, PM & Paudel, KR 2024, 'Neurodegenerative disorders: Mechanisms of degeneration and therapeutic approaches with their clinical relevance', Ageing Research Reviews, vol. 99, pp. 102357-102357.
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Gallagher, S, Johnstone, A, De Livera, A, Marsh, DJ & Walsh, S 2024, 'A survey of women diagnosed with breast cancer experiencing oncology treatment–induced hot flushes: identification of specific characteristics as predictors of hot flush occurrence, frequency, and severity', Journal of Cancer Survivorship, vol. 2024.
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Abstract Purpose More women diagnosed with breast cancer (BC) are living with oncology treatment–induced hot flushes (HFs). This Australian-based survey explores why some women experience more severe or ongoing HF and whether specific population characteristics are predictive of HF occurrence, frequency, and/or severity. Methods A non-probabilistic anonymous survey distributed online (Register4) and two Australian hospitals collected demographic and clinical information. Eligibility was consenting Australian-based women, 18 years and over, with a primary BC diagnosis. Analysis included linear and logistic regression models. Results A total of 324 survey responses were analyzed. Chemotherapy and hormone therapy were each associated with HF occurrence (aOR = 2.92, 95% CI [1.27, 6.70], p = 0.01; and aOR = 7.50, 95% CI [3.02, 18.62], p < 0.001) and in combination (aOR = 5.98, 95% CI [2.61, 13.69], p < 0.001). Increased self-reported anxiety at BC diagnosis was significantly associated with HF frequency and severity scores (aCO = 0.71, 95% CI [0.31, 1.12], p = 0.001; and aCO = 0.44, 95% CI [0.33, 0.55], p < 0.001). Postmenopausal women had significantly lower HF severity and frequency scores than premenopausal women (aCO = −0.93, 95% CI [−1.62, −0.25], p = 0.008; and aCO = −2.62, 95% CI [−5.14, −0.11], p = 0.041). Conclusions Women with BC receiving chemotherapy a...
Gangavarapu, K, Ji, X, Baele, G, Fourment, M, Lemey, P, Matsen, FA & Suchard, MA 2024, 'Many-core algorithms for high-dimensional gradients on phylogenetic trees', Bioinformatics, vol. 40, no. 2.
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Abstract Motivation Advancements in high-throughput genomic sequencing are delivering genomic pathogen data at an unprecedented rate, positioning statistical phylogenetics as a critical tool to monitor infectious diseases globally. This rapid growth spurs the need for efficient inference techniques, such as Hamiltonian Monte Carlo (HMC) in a Bayesian framework, to estimate parameters of these phylogenetic models where the dimensions of the parameters increase with the number of sequences N. HMC requires repeated calculation of the gradient of the data log-likelihood with respect to (wrt) all branch-length-specific (BLS) parameters that traditionally takes O(N2) operations using the standard pruning algorithm. A recent study proposes an approach to calculate this gradient in O(N), enabling researchers to take advantage of gradient-based samplers such as HMC. The CPU implementation of this approach makes the calculation of the gradient computationally tractable for nucleotide-based models but falls short in performance for larger state-space size models, such as Markov-modulated and codon models. Here, we describe novel massively parallel algorithms to calculate the gradient of the log-likelihood wrt all BLS parameters that take advantage of graphics processing units (GPUs) and result in many fold higher speedups over previous CPU implementations. Results We benchmark these GPU algorithms on three computing systems using three evolutionary inference examples exploring complete genomes from 997 dengue viruses, 62 carnivore mitochondria and 49 yeasts, and observe a >128-fold speedup over the CPU implementation for codon-based models and >8-fold speedup for nucleotide-based models. As a practical d...
Ganio, K, Nasreen, M, Yang, Z, Maunders, EA, Luo, Z, Hossain, SI, Ngu, DHY, Ellis, D, Gu, J, Neville, SL, Wilksch, J, Gunn, AP, Whittall, JJ, Kobe, B, Deplazes, E, Kappler, U & McDevitt, CA 2024, 'Hfe Permease and Haemophilus influenzae Manganese Homeostasis', ACS Infectious Diseases, vol. 10, no. 2, pp. 436-452.
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Gao, H, Li, J, Zhang, F, Li, C, Xiao, J, Nie, X, Zhang, G, Xiao, Y, Zhang, D, Guo, X, Wang, Y, Kang, Y, Wang, G & Liu, H 2024, 'Revealing the Potential and Challenges of High‐Entropy Layered Cathodes for Sodium‐Based Energy Storage', Advanced Energy Materials, vol. 14, no. 20.
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AbstractSodium‐ion batteries (SIBs) reflect a strategic move for scalable and sustainable energy storage. The focus on high‐entropy (HE) cathode materials, particularly layered oxides, has ignited scientific interest due to the unique characteristics and effects to tackle their shortcomings, such as inferior structural stability, sluggish reaction kinetics, severe Jahn‐Teller effects induced lattice distortion, and poor oxygen reversibility at high voltage. This review focuses on high‐entropy oxide materials, highlighting their fundamentals, design principles, and application in layered oxide cathodes for SIBs. It delves into the growth mechanism, composition‐properties correlations, and the functional roles of high‐entropy design in enhancing the performance of layered oxide cathodes. Furthermore, it furnishes a comprehensive survey of recent advancements and persisting challenges within the domain of layered high‐entropy cathode materials, as well as offers insights into potential future research directions in line with the current state of knowledge.
Gao, SY, Deng, K, Wang, J, Jin, FD, Huang, YL, Chen, ZH, Oliver, BG, Xie, M, Wan, HJ, Qin, L, Liu, D, Luo, FM, Chen-Yu Hsu, A, Li, WM, Wang, G & Wood, LG 2024, 'Homeostatic Measure of Insulin Resistance Is Associated With Future Asthma Exacerbations: A 1-Year Prospective Cohort Study', The Journal of Allergy and Clinical Immunology: In Practice, vol. 12, no. 10, pp. 2774-2784.e3.
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Ge, L, Liu, H, Yan, J, Sun, B, Li, Y & Hou, L 2024, 'A Novel Distributed PV Data Virtual Collection With Continuous-Binary Denoising Auto-Encoders', IEEE Transactions on Smart Grid, vol. 15, no. 1, pp. 1152-1164.
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Ghasemian, MB, Zavabeti, A, Allioux, F, Sharma, P, Mousavi, M, Rahim, MA, Khayyam Nekouei, R, Tang, J, Christofferson, AJ, Meftahi, N, Rafiezadeh, S, Cheong, S, Koshy, P, Tilley, RD, McConville, CF, Russo, SP, Ton‐That, C, Seidel, J & Kalantar‐Zadeh, K 2024, 'Liquid Metal Doping Induced Asymmetry in Two‐Dimensional Metal Oxides', Small, vol. 20, no. 27.
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AbstractThe emergence of ferroelectricity in two‐dimensional (2D) metal oxides is a topic of significant technological interest; however, many 2D metal oxides lack intrinsic ferroelectric properties. Therefore, introducing asymmetry provides access to a broader range of 2D materials within the ferroelectric family. Here, the generation of asymmetry in 2D SnO by doping the material with Hf0.5Zr0.5O2 (HZO) is demonstrated. A liquid metal process as a doping strategy for the preparation of 2D HZO‐doped SnO with robust ferroelectric characteristics is implemented. This technology takes advantage of the selective interface enrichment of molten Sn with HZO crystallites. Molecular dynamics simulations indicate a strong tendency of Hf and Zr atoms to migrate toward the surface of liquid metal and embed themselves within the growing oxide layer in the form of HZO. Thus, the liquid metal‐based harvesting/doping technique is a feasible approach devised for producing novel 2D metal oxides with induced ferroelectric properties, represents a significant development for the prospects of random‐access memories.
Gill, RL, Fleck, R, Chau, K, Westerhausen, MT, Lockwood, TE, Violi, JP, Irga, PJ, Doblin, MA & Torpy, FR 2024, 'Fine particle pollution during megafires contains potentially toxic elements', Environmental Pollution, vol. 344, pp. 123306-123306.
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Gomez, HM, Haw, TJ, Ilic, D, Robinson, P, Donovan, C, Croft, AJ, Vanka, KS, Small, E, Carroll, OR, Kim, RY, Mayall, JR, Beyene, T, Palanisami, T, Ngo, DTM, Zosky, GR, Holliday, EG, Jensen, ME, McDonald, VM, Murphy, VE, Gibson, PG & Horvat, JC 2024, 'Landscape fire smoke airway exposure impairs respiratory and cardiac function and worsens experimental asthma', Journal of Allergy and Clinical Immunology, vol. 154, no. 1, pp. 209-221.e6.
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Gonzalez de Vega, R, Clases, D, Cunningham, BA, Ganio, K, Neville, SL, McDevitt, CA & Doble, PA 2024, 'Spatial distribution of trace metals and associated transport proteins during bacterial infection', Analytical and Bioanalytical Chemistry, vol. 416, no. 11, pp. 2783-2796.
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Innate immune systems alter the concentrations of trace elements in host niches in response to invading pathogens during infection. This work reports the interplay between d-block metal ions and their associated biomolecules using hyphenated elemental techniques to spatially quantify both elemental distributions and the abundance of specific transport proteins. Here, lung tissues were collected for analyses from naïve and Streptococcus pneumoniae-infected mice fed on a zinc-restricted or zinc-supplemented diet. Spatiotemporal distributions of manganese (55Mn), iron (56Fe), copper (63Cu), and zinc (66Zn) were determined by quantitative laser ablation-inductively coupled plasma-mass spectrometry. The murine transport proteins ZIP8 and ZIP14, which are associated with zinc transport, were also imaged by incorporation of immunohistochemistry techniques into the analytical workflow. Collectively, this work demonstrates the potential of a single instrumental platform suitable for multiplex analyses of tissues and labelled antibodies to investigate complex elemental interactions at the host-pathogen interface. Further, these methods have the potential for broad application to investigations of biological pathways where concomitant measurement of elements and biomolecules is crucial to understand the basis of disease and aid in development of new therapeutic approaches.
Green, SM, Padula, MP, Dodgen, TM, Batarseh, A, Marks, DC & Johnson, L 2024, 'Lipidomic changes occurring in platelets during extended cold storage', Transfusion Medicine, vol. 34, no. 3, pp. 189-199.
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AbstractObjectivesCold storage is being implemented as an alternative to conventional room‐temperature storage for extending the shelf‐life of platelet components beyond 5–7 days. The aim of this study was to characterise the lipid profile of platelets stored under standard room‐temperature or cold (refrigerated) conditions.MethodsMatched apheresis derived platelet components in 60% PAS‐E/40% plasma (n = 8) were stored at room‐temperature (20–24°C with agitation) or in the cold (2–6°C without agitation). Platelets were sampled on day 1, 5 and 14. The lipidome was assessed by ultra‐pressure liquid chromatography ion mobility quadrupole time of flight mass spectrometry (UPLC IMS QToF). Changes in bioactive lipid mediators were measured by ELISA.ResultsThe total phospholipid and sphingolipid content of the platelets and supernatant were 44 544 ± 2915 μg/mL and 38 990 ± 10 880 μg/mL, respectively, and was similar over 14 days, regardless of storage temperature. The proportion of the procoagulant lipids, phosphatidylserine (PS) and phosphatidylethanolamine (PE), increased by 2.7% and 12.2%, respectively, during extended cold storage. Cold storage for 14 days increased sphingomyelin (SM) by 4.1% and decreased ceramide by 1.6% compared to day 1. Further, lysophosphatidylcholine (LPC) species remained unchanged during cold storage for 14 days. The concentration of 12‐ and 15‐hydroxyeicosatetraenoic acid (HETE) were lower in the supernatant of cold‐stored platelets than room‐temperature controls stored for 14 days.ConclusionThe lipid profile of platelets was relatively unchanged during storage for 5 days, regardless of temperature. However, during extended cold storage (14 days) the ...
Gross, N, Maestre, FT, Liancourt, P, Berdugo, M, Martin, R, Gozalo, B, Ochoa, V, Delgado-Baquerizo, M, Maire, V, Saiz, H, Soliveres, S, Valencia, E, Eldridge, DJ, Guirado, E, Jabot, F, Asensio, S, Gaitán, JJ, García-Gómez, M, Martínez, P, Martínez-Valderrama, J, Mendoza, BJ, Moreno-Jiménez, E, Pescador, DS, Plaza, C, Pijuan, IS, Abedi, M, Ahumada, RJ, Amghar, F, Arroyo, AI, Bahalkeh, K, Bailey, L, Ben Salem, F, Blaum, N, Boldgiv, B, Bowker, MA, Branquinho, C, van den Brink, L, Bu, C, Canessa, R, Castillo-Monroy, ADP, Castro, H, Castro, P, Chibani, R, Conceição, AA, Darrouzet-Nardi, A, Davila, YC, Deák, B, Donoso, DA, Durán, J, Espinosa, C, Fajardo, A, Farzam, M, Ferrante, D, Franzese, J, Fraser, L, Gonzalez, S, Gusman-Montalvan, E, Hernández-Hernández, RM, Hölzel, N, Huber-Sannwald, E, Jadan, O, Jeltsch, F, Jentsch, A, Ju, M, Kaseke, KF, Kindermann, L, le Roux, P, Linstädter, A, Louw, MA, Mabaso, M, Maggs-Kölling, G, Makhalanyane, TP, Issa, OM, Manzaneda, AJ, Marais, E, Margerie, P, Hughes, FM, Messeder, JVS, Mora, JP, Moreno, G, Munson, SM, Nunes, A, Oliva, G, Oñatibia, GR, Peter, G, Pueyo, Y, Quiroga, RE, Ramírez-Iglesias, E, Reed, SC, Rey, PJ, Reyes Gómez, VM, Rodríguez, A, Rolo, V, Rubalcaba, JG, Ruppert, JC, Sala, O, Salah, A, Sebei, PJ, Stavi, I, Stephens, C, Teixido, AL, Thomas, AD, Throop, HL, Tielbörger, K, Travers, S, Undrakhbold, S, Val, J, Valkó, O, Velbert, F, Wamiti, W, Wang, L, Wang, D, Wardle, GM, Wolff, P, Yahdjian, L, Yari, R, Zaady, E, Zeberio, JM, Zhang, Y, Zhou, X & Le Bagousse-Pinguet, Y 2024, 'Unforeseen plant phenotypic diversity in a dry and grazed world', Nature, vol. 632, no. 8026, pp. 808-814.
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Gulati, N, Chellappan, DK, MacLoughlin, R, Gupta, G, Singh, SK, Oliver, BG, Dua, K & Dureja, H 2024, 'Advances in nano-based drug delivery systems for the management of cytokine influx-mediated inflammation in lung diseases', Naunyn-Schmiedeberg's Archives of Pharmacology, vol. 397, no. 6, pp. 3695-3707.
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Gunawan, C, Fleming, C, Irga, PJ, Jien Wong, R, Amal, R, Torpy, FR, Mojtaba Golzan, S & McGrath, KC 2024, 'Neurodegenerative effects of air pollutant Particles: Biological mechanisms implicated for Early-Onset Alzheimer’s disease', Environment International, vol. 185, pp. 108512-108512.
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Hall, LM, Munasinghe, VS, Vella, NGF, Ellis, JT & Stark, D 2024, 'Observations on the transmission of Dientamoeba fragilis and the cyst life cycle stage', Parasitology, vol. 151, no. 3, pp. 337-345.
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AbstractLittle is known about the life cycle and mode of transmission of Dientamoeba fragilis. Recently it was suggested that fecal–oral transmission of cysts may play a role in the transmission of D. fragilis. In order to establish an infection, D. fragilis is required to remain viable when exposed to the pH of the stomach. In this study, we investigated the ability of cultured trophozoites to withstand the extremes of pH. We provide evidence that trophozoites of D. fragilis are vulnerable to highly acidic conditions. We also investigated further the ultrastructure of D. fragilis cysts obtained from mice and rats by transmission electron microscopy. These studies of cysts showed a clear cyst wall surrounding an encysted parasite. The cyst wall was double layered with an outer fibrillar layer and an inner layer enclosing the parasite. Hydrogenosomes, endoplasmic reticulum and nuclei were present in the cysts. Pelta-axostyle structures, costa and axonemes were identifiable and internal flagellar axonemes were present. This study therefore provides additional novel details and knowledge of the ultrastructure of the cyst stage of D. fragilis.
Hamzelou, S, Belobrajdic, D, Broadbent, JA, Juhász, A, Lee Chang, K, Jameson, I, Ralph, P & Colgrave, ML 2024, 'Utilizing proteomics to identify and optimize microalgae strains for high-quality dietary protein: a review', Critical Reviews in Biotechnology, vol. 44, no. 7, pp. 1280-1295.
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Algae-derived protein has immense potential to provide high-quality protein foods for the expanding human population. To meet its potential, a broad range of scientific tools are required to identify optimal algal strains from the hundreds of thousands available and identify ideal growing conditions for strains that produce high-quality protein with functional benefits. A research pipeline that includes proteomics can provide a deeper interpretation of microalgal composition and biochemistry in the pursuit of these goals. To date, proteomic investigations have largely focused on pathways that involve lipid production in selected microalgae species. Herein, we report the current state of microalgal proteome measurement and discuss promising approaches for the development of protein-containing food products derived from algae.
Hanna, T, Moret, S & Chadwick, S 2024, 'Fingermark quality: A survey of examiners and researchers', Forensic Science International, vol. 361, pp. 112100-112100.
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Harris, RJ, Alvarez, PR, Bryant, C, Briceño, VF, Cook, AM, Leigh, A & Nicotra, AB 2024, 'Acclimation of thermal tolerance in juvenile plants from three biomes is suppressed when extremes co-occur', Conservation Physiology, vol. 12, no. 1.
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Abstract Given the rising frequency of thermal extremes (heatwaves and cold snaps) due to climate change, comprehending how a plant’s origin affects its thermal tolerance breadth (TTB) becomes vital. We studied juvenile plants from three biomes: temperate coastal rainforest, desert and alpine. In controlled settings, plants underwent hot days and cold nights in a factorial design to examine thermal tolerance acclimation. We assessed thermal thresholds (Tcrit-hot and Tcrit-cold) and TTB. We hypothesized that (i) desert species would show the highest heat tolerance, alpine species the greatest cold tolerance and temperate species intermediate tolerance; (ii) all species would increase heat tolerance after hot days and cold tolerance after cold nights; (iii) combined exposure would broaden TTB more than individual conditions, especially in desert and alpine species. We found that biome responses were minor compared to the responses to the extreme temperature treatments. All plants increased thermal tolerance in response to hot 40°C days (Tcrit-hot increased by ~3.5°C), but there was minimal change in Tcrit-cold in response to the cold −2°C nights. In contrast, when exposed to both hot days and cold nights, on average, plants exhibited an antagonistic response in TTB, where cold tolerance decreased and heat tolerance was reduced, and so we did not see the bi-directional expansion we hypothesized. There was, however, considerable variation among species in these responses. As climate change intensifies, plant communities, especially in transitional seasons, will regularly face such temperature swings. Our results shed light on potential plant responses under these extremes, emphasizing the need for deeper species-specific thermal acclimation insights, ultimately guiding conservation efforts.
Hayes, C, Mitchell, A, Mellin, C, Booth, DJ, Ravasi, T & Nagelkerken, I 2024, 'Ecological generalism and physiology mediate fish biogeographic ranges under ocean warming', Proceedings of the Royal Society B: Biological Sciences, vol. 291, no. 2015, p. 20232206.
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Climate-driven species redistributions are facilitated by niche modifications that increase a species's chances of establishment in novel communities. It is well understood how range-extending species adjust individual niche traits when entering novel environments, yet whether modification of ecological niche traits collectively alters the pace of range extensions or contractions remains unknown. We quantified habitat niche, abundance, physiological performance and cellular defence/damage of range-extending coral reef fishes and coexisting local temperate fishes along a 2000 km latitudinal gradient. We also assessed their dietary and behavioural niches, and establishment potential, to understand whether ecological generalism facilitates successful range extension of coral reef fishes. The coral reef fish that increased all ecological niches, showed stronger establishment, increased physiological performance and cellular damage, but decreased cellular defence at their cold-range edge, whereas tropical species that showed unmodified ecological niches showed lower establishment. One temperate species showed decreased abundance, habitat niche width and body condition, but increased cellular defence, cellular damage and energy reserves at their warm-trailing range, while other temperate species showed contrasting responses. Therefore, ecological generalists might be more successful than ecological specialists during the initial stages of climate change, with increasing future warming strengthening this pattern by physiologically benefitting tropical generalists but disadvantaging temperate specialists.
He, LX, Deng, K, Wang, J, Zhang, X, Wang, L, Zhang, HP, Xie, M, Chen, ZH, Zhang, J, Chen-Yu Hsu, A, Zhang, L, Oliver, BG, Wark, PAB, Qin, L, Gao, P, Wan, HJ, Liu, D, Luo, FM, Li, WM, Wang, G & Gibson, PG 2024, 'Clinical Subtypes of Neutrophilic Asthma: A Cluster Analysis From Australasian Severe Asthma Network', The Journal of Allergy and Clinical Immunology: In Practice, vol. 12, no. 3, pp. 686-698.e8.
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He, Q, Liu, DL, Wang, B, Wang, Z, Cowie, A, Simmons, A, Xu, Z, Li, L, Shi, Y, Liu, K, Harrison, MT, Waters, C, Huete, A & Yu, Q 2024, 'A food-energy-water-carbon nexus framework informs region-specific optimal strategies for agricultural sustainability', Resources, Conservation and Recycling, vol. 203, pp. 107428-107428.
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He, S, Li, X & Sun, B 2024, 'Robust DOA estimation for two‐level nested arrays in unknown mutual coupling', Electronics Letters, vol. 60, no. 13.
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AbstractAiming at solving the problem that the capability of direction of arrival method for estimation of nested arrays decreases sharply under unknown mutual coupling, an iterative weighted low‐rank matrix reconstruction algorithm is proposed here. First, the received data covariance matrix is extended, and a weighted low‐rank matrix recovery problem is formulated for joint estimations of the Toeplitz matrix and mutual coupling coefficients. Next, the direction of arrival from recovered Toeplitz matrix is retrieved by using the root multiple signal classification algorithm. Simulation results show that iterative weighted low‐rank matrix reconstruction algorithm can effectively avoid the influence of mutual coupling while solving the grid‐mismatch problem so that the accuracy and the resolution of estimation are improved.
He, VX & Wand, MP 2024, 'Bayesian generalized additive model selection including a fast variational option', AStA Advances in Statistical Analysis, vol. 108, no. 3, pp. 639-668.
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He, Z, Wang, C, Guo, X, Sun, H, Bi, Y, Pitt, ME, Li, C, Song, J, Coin, LJM & Li, F 2024, 'MERITS: a web-based integrated Mycobacterial PE/PPE protein database', Bioinformatics Advances, vol. 4, no. 1.
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Abstract Motivation PE/PPE proteins, highly abundant in the Mycobacterium genome, play a vital role in virulence and immune modulation. Understanding their functions is key to comprehending the internal mechanisms of Mycobacterium. However, a lack of dedicated resources has limited research into PE/PPE proteins. Results Addressing this gap, we introduce MycobactERIal PE/PPE proTeinS (MERITS), a comprehensive 3D structure database specifically designed for PE/PPE proteins. MERITS hosts 22 353 non-redundant PE/PPE proteins, encompassing details like physicochemical properties, subcellular localization, post-translational modification sites, protein functions, and measures of antigenicity, toxicity, and allergenicity. MERITS also includes data on their secondary and tertiary structure, along with other relevant biological information. MERITS is designed to be user-friendly, offering interactive search and data browsing features to aid researchers in exploring the potential functions of PE/PPE proteins. MERITS is expected to become a crucial resource in the field, aiding in developing new diagnostics and vaccines by elucidating the sequence-structure-functional relationships of PE/PPE proteins. Availability and implementation MERITS is freely accessible at http://merits.unimelb-biotools.cloud.edu.au/.
Healey, AJ, Singh, P, Robertson, IO, Gavin, C, Scholten, SC, Broadway, DA, Reineck, P, Abe, H, Ohshima, T, Kianinia, M, Aharonovich, I & Tetienne, J-P 2024, 'Optimisation of electron irradiation for creating spin ensembles in hexagonal boron nitride', Materials for Quantum Technology, vol. 4, no. 3, pp. 035701-035701.
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Abstract Boron vacancy centre ( V B − ) ensembles in hexagonal boron nitride (hBN) have attracted recent interest for their potential as two-dimensional solid-state quantum sensors. Irradiation is necessary for V B − creation, however, to date only limited attention has been given to optimising the defect production process, especially in the case of bulk irradiation with high-energy particles, which offers scalability through the potential for creating ensembles in large volumes of material. Here we systematically investigate the effect of electron irradiation by varying the dose delivered to a range of hBN samples, which differ in their purity, and search for an optimum in measurement sensitivity. We find that moderate electron irradiation doses ( Science of The Total Environment, vol. 909, pp. 168608-168608.
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Hennessey, M, Whitefield, B, Singh, P, Alijani, H, Abe, H, Ohshima, T, Gavin, C, Broadway, DA, Toth, M, Tetienne, J-P, Aharonovich, I & Kianinia, M 2024, 'Engineering Boron Vacancy Defects in Boron Nitride Nanotubes', ACS Applied Materials & Interfaces, vol. 16, no. 42, pp. 57552-57557.
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Hilton, JBW, Kysenius, K, Liddell, JR, Mercer, SW, Hare, DJ, Buncic, G, Paul, B, Wang, Y, Murray, SS, Kilpatrick, TJ, White, AR, Donnelly, PS & Crouch, PJ 2024, 'Evidence for decreased copper associated with demyelination in the corpus callosum of cuprizone-treated mice', Metallomics, vol. 16, no. 1.
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Abstract Demyelination within the central nervous system (CNS) is a significant feature of debilitating neurological diseases such as multiple sclerosis and administering the copper-selective chelatorcuprizone to mice is widely used to model demyelination in vivo. Conspicuous demyelination within the corpus callosum is generally attributed to cuprizone's ability to restrict copper availability in this vulnerable brain region. However, the small number of studies that have assessed copper in brain tissue from cuprizone-treated mice have produced seemingly conflicting outcomes, leaving the role of CNS copper availability in demyelination unresolved. Herein we describe our assessment of copper concentrations in brain samples from mice treated with cuprizone for 40 d. Importantly, we applied an inductively coupled plasma mass spectrometry methodology that enabled assessment of copper partitioned into soluble and insoluble fractions within distinct brain regions, including the corpus callosum. Our results show that cuprizone-induced demyelination in the corpus callosum was associated with decreased soluble copper in this brain region. Insoluble copper in the corpus callosum was unaffected, as were pools of soluble and insoluble copper in other brain regions. Treatment with the blood–brain barrier permeant copper compound CuII(atsm) increased brain copper levels and this was most pronounced in the soluble fraction of the corpus callosum. This effect was associated with significant mitigation of cuprizone-induced demyelination. These results provide support for the involvement of decreased CNS copper availability in demyelination in the cuprizone model. Relevance to human demyelinating disease is discussed.
Hilton, JBW, Kysenius, K, Liddell, JR, Mercer, SW, Rautengarten, C, Hare, DJ, Buncic, G, Paul, B, Murray, SS, McLean, CA, Kilpatrick, TJ, Beckman, JS, Ayton, S, Bush, AI, White, AR, Roberts, BR, Donnelly, PS & Crouch, PJ 2024, 'Integrated elemental analysis supports targeting copper perturbations as a therapeutic strategy in multiple sclerosis', Neurotherapeutics, vol. 21, no. 5, pp. e00432-e00432.
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Hinners, J, Argyle, PA, Walworth, NG, Doblin, MA, Levine, NM & Collins, S 2024, 'Multi-trait diversification in marine diatoms in constant and warmed environments', Proceedings of the Royal Society B: Biological Sciences, vol. 291, no. 2019, p. 20232564.
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Phytoplankton are photosynthetic marine microbes that affect food webs, nutrient cycles and climate regulation. Their roles are determined by correlated phytoplankton functional traits including cell size, chlorophyll content and cellular composition. Here, we explore patterns of evolution in interrelated trait values and correlations. Because both chance events and natural selection contribute to phytoplankton trait evolution, we used population bottlenecks to diversify six genotypes of Thalassiosirid diatoms. We then evolved them as large populations in two environments. Interspecific variation and within-species evolution were visualized for nine traits and their correlations using reduced axes (a trait-scape). Our main findings are that shifts in trait values resulted in movement of evolving populations within the trait-scape in both environments, but were more frequent when large populations evolved in a novel environment. Which trait relationships evolved was population-specific, but greater departures from ancestral trait correlations were associated with lower population growth rates. There was no single master trait that could be used to understand multi-trait evolution. Instead, repeatable multi-trait evolution occurred along a major axis of variation defined by several diatom traits and trait relationships. Because trait-scapes capture changes in trait relationships and values together, they offer an insightful way to study multi-trait variation.
Ho, JSS, Ping, TL, Paudel, KR, El Sherkawi, T, De Rubis, G, Yeung, S, Hansbro, PM, Oliver, BGG, Chellappan, DK, Sin, KP & Dua, K 2024, 'Exploring Bioactive Phytomedicines for Advancing Pulmonary Infection Management: Insights and Future Prospects', Phytotherapy Research.
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ABSTRACTPulmonary infections have a profound influence on global mortality rates. Medicinal plants offer a promising approach to address this challenge, providing nontoxic alternatives with higher levels of public acceptance and compliance, particularly in regions where access to conventional medications or diagnostic resources may be limited. Understanding the pathophysiology of viruses and bacteria enables researchers to identify biomarkers essential for triggering diseases. This knowledge allows the discovery of biological molecules capable of either preventing or alleviating symptoms associated with these infections. In this review, medicinal plants that have an effect on COVID‐19, influenza A, bacterial and viral pneumonia, and tuberculosis are discussed. Drug delivery has been briefly discussed as well. It examines the effect of bioactive constituents of these plants and synthesizes findings from in vitro, in vivo, and clinical studies conducted over the past decade. In conclusion, many medicinal plants can be used to treat pulmonary infections, but further in‐depth studies are needed as most of the current studies are only at preliminary stages. Extensive investigation and clinical studies are warranted to fully elucidate their mechanisms of action and optimize their use in clinical practice.
Hoffmann, R, Meakin, GE, Morelato, M & Roux, C 2024, 'The utility of trace DNA within forensic science for investigative and intelligence purposes', WIREs Forensic Science, vol. 6, no. 4.
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AbstractForensic science not only provides evidence to support criminal investigations, but also contributes to knowledge surrounding criminal phenomena. Forensic scientists are in the unique position to strategically combine information gained from traces to create intelligence that can assist the security space in keeping our communities safe. Research into the use of traces for more than just criminal investigations, with a focus on the greater “utility” of a trace, has pointed to the broader problem‐solving potential of traces when more fully exploited. Alongside this, there has continued to be an exponential increase of the use of biological traces for criminal investigations, in particular the collection of trace DNA specimens. The potential for identification, among other information, trace DNA can provide is vast, however much of the previous research has predominately focused on recovery rates which does not provide a holistic view of the value of trace DNA. This paper summarizes the current knowledge on the utility of trace DNA, as well as makes suggestions toward the creation of a decision‐making model that can inform scene of crime officers in regards to trace selection and decisions about trace analysis.This article is categorized under:Forensic Biology > DNA Databases and BiometricsCrime Scene Investigation > From Traces to Intelligence and Evidence
Horder, J & Aharonovich, I 2024, 'Optical manipulation of spin resonance in gallium nitride', Nature Photonics, vol. 18, no. 4, pp. 309-310.
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Hossain, MS, Bacaoco, M, Mai, TNA, Ponchon, G, Chen, C, Ding, L, Chen, Y, Ekimov, E, Xu, X, Solntsev, AS & Tran, TT 2024, 'Fiber-Based Ratiometric Optical Thermometry with Silicon Vacancy in Microdiamonds', ACS Applied Optical Materials, vol. 2, no. 1, pp. 97-107.
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Hossain, ST & Mahmud, MAP 2024, 'Optimizing process parameters and materials for the conversion of plastic waste into hydrogen', Engineering Research Express, vol. 6, no. 4, pp. 045319-045319.
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Abstract This study has investigated hydrogen production from waste plastics using pyrolysis, steam methane reforming, and water-gas-shift reactions modelled via Aspen Plus. After evaluating multiple alternatives, polypropylene (PP) was selected as the feedstock. The research has been focused on how reformer temperature, steam-to-fuel ratio (S/F), reformer pressure, and pyrolysis temperature impact syngas composition, heating values, syngas (H2/CO) ratios, and yields of hydrogen (H2), methane (CH4), and carbon dioxide (CO2). Key findings have indicated that raising reformer temperatures to around 1000°C maximizes hydrogen production in syngas, reaching peak levels of 2360 Nm3/Ton and 2525 Nm3/Ton for reformer temperature and steam-to-fuel ratio (S/F) ratios, respectively, via processes like steam methane reforming and the water-gas-shift reaction. Moreover, other parameters like steam-to-fuel (S/F) ratio and reformer pressure have produced the highest amount of hydrogen at 0.25 and 1 atm, respectively. Optimizing reformer temperature and steam-to-fuel ratio (S/F) have been selected as key in hydrogen production, with peak lower heating values (LHV) of 1.15 MJ/kg for temperature and 1.035 MJ/kg for S/F ratios, highlighting the importance of balancing these parameters for efficiency. Additionally, syngas' hydrogen (H2) composition increased with pyrolysis temperature, peaking at 8.5% at 700°C. Finally, this research has provided valuable insights into optimizing process parameters for sustainable hydrogen production. Moreover, the simulation process has provided cost-effective adjustments and informed decision-making for sustainable and scalable technologies, benefiting researchers, investors, engineers, and policymakers involved in innovative hydrogen generation.
Hou, S, Gao, X, Lv, X, Zhao, Y, Yin, X, Liu, Y, Fang, J, Yu, X, Ma, X, Ma, T & Su, D 2024, 'Decade Milestone Advancement of Defect-Engineered g-C3N4 for Solar Catalytic Applications', Nano-Micro Letters, vol. 16, no. 1.
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AbstractOver the past decade, graphitic carbon nitride (g-C3N4) has emerged as a universal photocatalyst toward various sustainable carbo-neutral technologies. Despite solar applications discrepancy, g-C3N4 is still confronted with a general fatal issue of insufficient supply of thermodynamically active photocarriers due to its inferior solar harvesting ability and sluggish charge transfer dynamics. Fortunately, this could be significantly alleviated by the “all-in-one” defect engineering strategy, which enables a simultaneous amelioration of both textural uniqueness and intrinsic electronic band structures. To this end, we have summarized an unprecedently comprehensive discussion on defect controls including the vacancy/non-metallic dopant creation with optimized electronic band structure and electronic density, metallic doping with ultra-active coordinated environment (M–Nx, M–C2N2, M–O bonding), functional group grafting with optimized band structure, and promoted crystallinity with extended conjugation π system with weakened interlayered van der Waals interaction. Among them, the defect states induced by various defect types such as N vacancy, P/S/halogen dopants, and cyano group in boosting solar harvesting and accelerating photocarrier transfer have also been emphasized. More importantly, the shallow defect traps identified by femtosecond transient absorption spectra (fs-TAS) have also been highlighted. It is believed that this review would pave the way for future readers with a unique insight into a more precise defective g-C3N4 “customization”, motivating more profound thinking and flourishing research outputs on g-C3N4-based photoca...
Howlett, L, Camp, EF, Locatelli, NS, Baums, IB, Strudwick, P, Rassmussen, S & Suggett, DJ 2024, 'Population and clonal structure of Acropora cf. hyacinthus to inform coral restoration practices on the Great Barrier Reef', Coral Reefs, vol. 43, no. 4, pp. 1023-1035.
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AbstractA key goal of coral restoration is to re-establish self-sustaining coral populations and ensure resilience to future stressors, which requires that genetic diversity is maximised. However, coral genetic and genotypic (clonal) diversity is variable across reef sites via success of sexual recruitment, and cryptic species diversity can complicate breeding efforts. Assessing genotypic and genetic diversity of colonies to be used in restoration is therefore critical to avoid founder, inbreeding or outbreeding effects. Considering recent efforts to upscale coral propagation on the Great Barrier Reef (GBR), we examined species, population and clonal structure of a commonly out-planted tabular Acropora species—Acropora hyacinthus (Dana, 1864). A total of 189 colonies were sampled from six reef systems throughout the northern-central GBR and genotyped using an Acropora-specific Affymetrix microarray, which resulted in 1387 variant sites that passed quality control. Cryptic species were readily resolved and all sampled A. hyacinthus colonies represented unique genotypes within sites at three reefs. At reefs that contained multi-ramet genets (clonal genotypes), the mean and maximum between-ramet distances were 0.68 and 1.99 m, respectively. Therefore, sampling colonies > 2 m apart increases the likelihood these colonies represent distinct genets. Such a sampling design therefore maximises genotypic diversity when sourcing colonies for propagation and out-planting. Based on these variant sites, we found no between-reef genetic divergence based on locality. Furthermore, through unintentional sampling of non-target tabular Acroporid species, we show how this genotyping method may be used for resolving taxonomic uncertainty as well as population dynamics.
Htet, CS, Manjón-Sanz, AM, Liu, J, Babori, C, Barati, M, Marlton, FP, Daniel, L, Jørgensen, MRV & Pramanick, A 2024, 'Local structural mechanism for enhanced energy storage properties in heterovalent doped NaNbO3 ceramics', Journal of the European Ceramic Society, vol. 44, no. 3, pp. 1597-1609.
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Hu, R, Geng, Y, Huang, Y, Liu, Z, Li, F, Dong, H, Ma, W, Song, K, Zhang, M, Zhang, Z & Song, Y 2024, 'New insights into the interaction between polycystic ovary syndrome and psychiatric disorders: A narrative review', International Journal of Gynecology & Obstetrics, vol. 164, no. 2, pp. 387-420.
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AbstractPolycystic ovary syndrome (PCOS) is a prevalent endocrine disease characterized by hyperandrogenism, ovulatory dysfunction, and ovarian polycystic changes, which combines with reproductive problems, metabolic disorders, and psychological disorders to exhibit a far‐reaching impact on the physical and mental health of women. We reviewed previous research and discovered that psychiatric disorders are more common in PCOS patients and their children, potentially exacerbating the condition and creating a vicious loop. To understand the reasons, relevant articles were collected following the Preferred Reporting Items for Systematic Reviews and Meta‐analyses guidelines from PubMed, Web of Science, and Cochrane Library, through December 2022. Evidence suggested that PCOS‐related clinical manifestations, hyperandrogenism, insulin resistance, obesity, gut dysbiosis, and other variables may increase the risk of psychiatric disorders in patients. In turn, psychiatric disorders may aggravate the pathologic process of PCOS and increase the difficulty of the treatment. We systematically reported the mechanisms underlying the psychiatric disorders‐PCOS interactions, intending to provide potential ways to break the vicious cycle and lay the groundwork for future research. However, research on PCOS and psychiatric disorders were still in initial stages, which limited the scope of this review. More studies are needed to further verify our findings.
Huang, D, Zhang, L, Liu, Y, Wang, J, Zhang, J, Baines, KJ, Liu, G, Hsu, AC-Y, Wang, F, Chen, Z, Oliver, BG, Xie, M, Qin, L, Liu, D, Wan, H, Luo, F, Li, W, Wang, G & Gibson, PG 2024, 'Activated non-neuronal cholinergic system correlates with non-type 2 inflammation and exacerbations in severe asthma', Annals of Allergy, Asthma & Immunology, vol. 133, no. 1, pp. 64-72.e4.
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Huang, JE, Chen, Y, Ou, P, Ding, X, Yan, Y, Dorakhan, R, Lum, Y, Li, X-Y, Bai, Y, Wu, C, Fan, M, Lee, MG, Miao, RK, Liu, Y, O’Brien, C, Zhang, J, Tian, C, Liang, Y, Xu, Y, Luo, M, Sinton, D & Sargent, EH 2024, 'Selective Electrified Propylene-to-Propylene Glycol Oxidation on Activated Rh-Doped Pd', Journal of the American Chemical Society, vol. 146, no. 12, pp. 8641-8649.
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Huang, Z, Farahmandjou, M, Marlton, F, Guo, X, Gao, H, Sun, B & Wang, G 2024, 'Surface and structure engineering of MXenes for rechargeable batteries beyond lithium', Journal of Materiomics, vol. 10, no. 1, pp. 253-268.
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Hussain, MS, Altamimi, ASA, Afzal, M, almalki, WH, Kazmi, I, Alzarea, SI, Saleem, S, Prasher, P, Oliver, B, Singh, SK, MacLoughlin, R, Dua, K & Gupta, G 2024, 'From carcinogenesis to therapeutic avenues: lncRNAs and mTOR crosstalk in lung cancer', Pathology - Research and Practice, vol. 253, pp. 155015-155015.
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Hussain, S, Gupta, G, Shahwan, M, Bansal, P, Kaur, H, Deorari, M, Pant, K, Ali, H, Singh, SK, Rama Raju Allam, VS, Paudel, KR, Dua, K, Kumarasamy, V & Subramaniyan, V 2024, 'Non-coding RNA: A key regulator in the Glutathione-GPX4 pathway of ferroptosis', Non-coding RNA Research, vol. 9, no. 4, pp. 1222-1234.
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Huston, W 2024, 'Immunological responses in a Chlamydia trachomatis vaccine trial', The Lancet Infectious Diseases, vol. 24, no. 8, pp. 795-796.
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Idrees, S & Paudel, KR 2024, 'Bioinformatics prediction and screening of viral mimicry candidates through integrating known and predicted DMI data', Archives of Microbiology, vol. 206, no. 1.
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Idrees, S & Paudel, KR 2024, 'Proteome‐wide assessment of human interactome as a source of capturing domain–motif and domain‐domain interactions', Journal of Cell Communication and Signaling, vol. 18, no. 1.
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AbstractProtein–protein interactions (PPIs) play a crucial role in various biological processes by establishing domain–motif (DMI) and domain–domain interactions (DDIs). While the existence of real DMIs/DDIs is generally assumed, it is rarely tested; therefore, this study extensively compared high‐throughput methods and public PPI repositories as sources for DMI and DDI prediction based on the assumption that the human interactome provides sufficient data for the reliable identification of DMIs and DDIs. Different datasets from leading high‐throughput methods (Yeast two‐hybrid [Y2H], Affinity Purification coupled Mass Spectrometry [AP‐MS], and Co‐fractionation‐coupled Mass Spectrometry) were assessed for their ability to capture DMIs and DDIs using known DMI/DDI information. High‐throughput methods were not notably worse than PPI databases and, in some cases, appeared better. In conclusion, all PPI datasets demonstrated significant enrichment in DMIs and DDIs (p‐value <0.001), establishing Y2H and AP‐MS as reliable methods for predicting these interactions. This study provides valuable insights for biologists in selecting appropriate methods for predicting DMIs, ultimately aiding in SLiM discovery.
Idrees, S, Paudel, KR & Hansbro, PM 2024, 'Prediction of motif-mediated viral mimicry through the integration of host–pathogen interactions', Archives of Microbiology, vol. 206, no. 3.
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AbstractOne of the mechanisms viruses use in hijacking host cellular machinery is mimicking Short Linear Motifs (SLiMs) in host proteins to maintain their life cycle inside host cells. In the face of the escalating volume of virus-host protein–protein interactions (vhPPIs) documented in databases; the accurate prediction of molecular mimicry remains a formidable challenge due to the inherent degeneracy of SLiMs. Consequently, there is a pressing need for computational methodologies to predict new instances of viral mimicry. Our present study introduces a DMI-de-novo pipeline, revealing that vhPPIs catalogued in the VirHostNet3.0 database effectively capture domain-motif interactions (DMIs). Notably, both affinity purification coupled mass spectrometry and yeast two-hybrid assays emerged as good approaches for delineating DMIs. Furthermore, we have identified new vhPPIs mediated by SLiMs across different viruses. Importantly, the de-novo prediction strategy facilitated the recognition of several potential mimicry candidates implicated in the subversion of host cellular proteins. The insights gleaned from this research not only enhance our comprehension of the mechanisms by which viruses co-opt host cellular machinery but also pave the way for the development of novel therapeutic interventions.
Idrees, S, Paudel, KR, Sadaf, T & Hansbro, PM 2024, 'Uncovering domain motif interactions using high‐throughput protein–protein interaction detection methods', FEBS Letters, vol. 598, no. 7, pp. 725-742.
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Protein–protein interactions (PPIs) are often mediated by short linear motifs (SLiMs) in one protein and domain in another, known as domain–motif interactions (DMIs). During the past decade, SLiMs have been studied to find their role in cellular functions such as post‐translational modifications, regulatory processes, protein scaffolding, cell cycle progression, cell adhesion, cell signalling and substrate selection for proteasomal degradation. This review provides a comprehensive overview of the current PPI detection techniques and resources, focusing on their relevance to capturing interactions mediated by SLiMs. We also address the challenges associated with capturing DMIs. Moreover, a case study analysing the BioGrid database as a source of DMI prediction revealed significant known DMI enrichment in different PPI detection methods. Overall, it can be said that current high‐throughput PPI detection methods can be a reliable source for predicting DMIs.
Insuasty, A, Carrara, S, Xuechen, J, McNeill, CR, Hogan, C & Langford, SJ 2024, 'Aggregation‐Induced Emission of Naphthalene Diimides: Effect of Chain Length on Liquid and Solid‐Phase Emissive Properties', Chemistry – An Asian Journal, vol. 19, no. 9.
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AbstractThe aggregation‐induced emission (AIE) properties of a systematic series of naphthalene diimides (NDIs) varying the chain length at the imide positions have been studied. A solvophobic collapse of NDI units through the flash injection of THF NDI solutions in sonicating water triggers the formation of stable suspensions with enhanced fluorescence emissions. Shorter chains favor the π‐π stacking of NDI units through H‐aggregation producing a strong AIE effect showing remarkably high quantum yields that have not been observed for non core‐substitued NDIs previously. On the other hand, NDIs functionalized with longer chains lead to more disordered domains where π‐π stacking between NDI units is mainly given by J‐aggregation unfavoring the AIE effect.
Ithurbide, S, de Silva, RT, Brown, HJ, Shinde, V & Duggin, IG 2024, 'A vector system for single and tandem expression of cloned genes and multi-colour fluorescent tagging in Haloferax volcanii', Microbiology, vol. 170, no. 5.
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Archaeal cell biology is an emerging field expected to identify fundamental cellular processes, help resolve the deep evolutionary history of cellular life, and contribute new components and functions in biotechnology and synthetic biology. To facilitate these, we have developed plasmid vectors that allow convenient cloning and production of proteins and fusion proteins with flexible, rigid, or semi-rigid linkers in the model archaeon Haloferax volcanii. For protein subcellular localization studies using fluorescent protein (FP) tags, we created vectors incorporating a range of codon-optimized fluorescent proteins for N- or C-terminal tagging, including GFP, mNeonGreen, mCherry, YPet, mTurquoise2 and mScarlet-I. Obtaining functional fusion proteins can be challenging with proteins involved in multiple interactions, mainly due to steric interference. We demonstrated the use of the new vector system to screen for improved function in cytoskeletal protein FP fusions, and identified FtsZ1–FPs that are functional in cell division and CetZ1–FPs that are functional in motility and rod cell development. Both the type of linker and the type of FP influenced the functionality of the resulting fusions. The vector design also facilitates convenient cloning and tandem expression of two genes or fusion genes, controlled by a modified tryptophan-inducible promoter, and we demonstrated its use for dual-colour imaging of tagged proteins in H. volcanii cells. These tools should promote further development and applications of archaeal molecular and cellular biology and biotechnology.
Jacobson, JL, Akkaya‐Hocagil, T, Jacobson, SW, Coles, CD, Richardson, GA, Olson, HC, Day, NL, Carter, RC, Dodge, NC, Dang, K, Cook, RJ & Ryan, LM 2024, 'A dose–response analysis of the effects of prenatal alcohol exposure on cognitive development', Alcohol, Clinical and Experimental Research, vol. 48, no. 4, pp. 623-639.
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AbstractBackgroundMost studies of the effects of prenatal alcohol exposure (PAE) on cognitive function have assumed that the dose–response curve is linear. However, data from a few animal and human studies suggest that there may be an inflection point in the dose–response curve above which PAE effects are markedly stronger and that there may be differences associated with pattern of exposure, assessed in terms of alcohol dose per drinking occasion and drinking frequency.MethodsWe performed second‐order confirmatory factor analysis on data obtained at school age, adolescence, and early adulthood from 2227 participants in six US longitudinal cohorts to derive a composite measure of cognitive function. Regression models were constructed to examine effects of PAE on cognitive function, adjusted for propensity scores. Analyses based on a single predictor (absolute alcohol (AA)/day) were compared with analyses based on two predictors (dose/occasion and drinking frequency), using (1) linear models and (2) nonparametric general additive models (GAM) that allow for both linear and nonlinear effects.ResultsThe single‐predictor GAM model showed virtually no nonlinearity in the effect of AA/day on cognitive function. However, the two‐predictor GAM model revealed differential effects of maternal drinking pattern. Among offspring of infrequent drinkers, PAE effects on cognitive function were markedly stronger in those whose mothers drank more than ~3 drinks/occasion, and the effect of dose/occasion was strongest among the very frequent drinkers. Frequency of drinking did not appear to alter the PAE effect on cognitive function among participants born to mothers who limited their drinking to ~1 drink/occasion or less.Conclusions
Jarocki, VM, Li, D, Bogema, DR, Yam, J, Jenkins, C, Hai, FI & Djordjevic, SP 2024, 'Comparative genomic analysis of ESBL-selected and non-selected Escherichia coli in Australian wastewater: Elucidating differences in diversity, antimicrobial resistance, and virulence profiles', Science of The Total Environment, vol. 949, pp. 175079-175079.
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Jerin, A, Mahmud, MAP, Ackland, ML & Kouzani, AZ 2024, 'Recent progress on carbon footprint assessment of healthcare services', Environmental Research Communications, vol. 6, no. 10, pp. 102001-102001.
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Abstract As a result of the carbon-intensive nature of health care, hospital facilities are contributors to global warming. Health care’s contributions to global warming and greenhouse gas emissions include those associated with carbon emissions, energy consumption, pharmaceuticals, travel-related emissions and procurement. This article presents a review of environmental impact of different medical services. The published research articles focused on estimating the carbon footprint of healthcare services are investigated here. This review also discusses methods used for determining greenhouse gas emissions. Life cycle assessment and component analysis are the two most used methods for calculating emissions. This study also highlights the existing challenges related to estimation of carbon emission of different healthcare services and ways to overcome these challenges associated with carbon emission. The findings reveal substantial variability in carbon footprint estimates depending on region, settings, and usage patterns, with energy consumption identified as the primary source of greenhouse gas emissions. The review also addresses challenges in data availability, the accuracy of estimations, and the exclusion of critical factors like the environmental impact of medical equipment manufacturing. To mitigate healthcare’s carbon footprint, the study underscores the importance of transitioning from fossil fuels to renewable energy, minimizing unnecessary medical procedures, and promoting the use of reusable instruments. These insights are essential for developing more accurate and comprehensive strategies to reduce the carbon footprint of healthcare services globally.
Jessamine, V, Mehndiratta, S, De Rubis, G, Paudel, KR, Shetty, S, Suares, D, Chellappan, DK, Oliver, BG, Hansbro, PM & Dua, K 2024, 'The application of nanoparticles as advanced drug delivery systems in Attenuating COPD', Heliyon, vol. 10, no. 3, pp. e25393-e25393.
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Jha, LA, Kumar, B, Jha, SK & Paudel, KR 2024, 'Futuristic Senolytic Drug Incorporated Nanomedicine Therapy to Treat Osteoarthritis', Nanomedicine, vol. 19, no. 10, pp. 837-840.
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Jha, SK, De Rubis, G, Devkota, SR, Zhang, Y, Adhikari, R, Jha, LA, Bhattacharya, K, Mehndiratta, S, Gupta, G, Singh, SK, Panth, N, Dua, K, Hansbro, PM & Paudel, KR 2024, 'Cellular senescence in lung cancer: Molecular mechanisms and therapeutic interventions', Ageing Research Reviews, vol. 97, pp. 102315-102315.
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Jha, SK, Imran, M, Anwaar, S, Hansbro, PM, Paudel, KR & Mohammed, Y 2024, 'Mesenchymal stem cell membrane-coated nanoconstructs: why have they not yet found a home in clinical practice?', Nanomedicine, vol. 19, no. 17, pp. 1507-1510.
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Jing, L, Deplazes, E, Clegg, JK & Wu, X 2024, 'A charge-neutral organic cage selectively binds strongly hydrated sulfate anions in water', Nature Chemistry, vol. 16, no. 3, pp. 335-342.
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Johansen, MD, Spaink, HP, Oehlers, SH & Kremer, L 2024, 'Modeling nontuberculous mycobacterial infections in zebrafish', Trends in Microbiology, vol. 32, no. 7, pp. 663-677.
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Johnston, NP, Pape, T, Piwczyński, M, Wallman, JF, Wiegmann, BM, Cassel, BK, Akbarzadeh, K & Szpila, K 2024, 'Anchored phylogenomics and revised classification of the Miltogramminae (Diptera: Sarcophagidae)', Systematic Entomology, vol. 49, no. 1, pp. 138-155.
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AbstractThe Miltogramminae (Diptera: Sarcophagidae) includes ~600 species across >40 genera, which constitute ~20% of global Sarcophagidae. While molecular phylogenetic hypotheses have been produced for this group, critical problems persist, including the presence of paraphyletic genera, uncertain relationships between genera, a bias of sampling towards Palaearctic taxa, and low support for many branches. The present study remedies these issues through the application of Anchored Hybrid Enrichment (AHE) to a sample including ~60% of the currently recognised genera (16% of known species) representing all biogeographic regions except the Neotropical. An alignment of 1,281 concatenated loci was analysed with maximum likelihood (RAxML, IQ‐TREE), Bayesian inference (ExaBayes) and coalescent‐based approaches (ASTRAL, SVDquartets), which resulted in highly supported and concordant topologies, providing unprecedented insight into the relationships of this subfamily of flesh flies, allowing a major update to miltogrammine classification. The AHE phylogenetic hypothesis supports the monophyly of a large proportion of genera. The monophyly of Metopia Meigen is restored by synonymy with Aenigmetopia Malloch, syn.n. To achieve monophyly of Miltogramma Meigen, eight species are transferred from Pterella Robineau‐Desvoidy. The genus Pterella is shown to be paraphyletic in its current circumscription, and to restore generic monophyly Pterella is restricted to contain only Pt. grisea (Meigen). Erioprocta Enderlein, stat.rev., is resurrected. The genus Senotainia Macquart is reconstructed as paraphyletic. The monotypic genus Metopodia
Kakoty, V, Sarathlal, KC, Kaur, P, Wadhwa, P, Vishwas, S, Khan, FR, Alhazmi, AYM, Almasoudi, HH, Gupta, G, Chellappan, DK, Paudel, KR, Kumar, D, Dua, K & Singh, SK 2024, 'Unraveling the role of glial cell line–derived neurotrophic factor in the treatment of Parkinson’s disease', Neurological Sciences, vol. 45, no. 4, pp. 1409-1418.
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Kar, S, Das, SS, Kundu, S, Sahu, BD, Kumar, KJ, Kesari, KK & Singh, SK 2024, 'Intranasal Delivery of Carvedilol- and Quercetin-Encapsulated Cationic Nanoliposomes for Cardiovascular Targeting: Formulation and In Vitro and Ex Vivo Studies', ACS Applied Bio Materials, vol. 7, no. 5, pp. 3061-3085.
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Karami, H, Kamruzzaman, M, Covington, JA, Hassouna, MÉ, Darvishi, Y, Ueland, M, Fuentes, S & Gancarz, M 2024, 'Advanced evaluation techniques: Gas sensor networks, machine learning, and chemometrics for fraud detection in plant and animal products', Sensors and Actuators A: Physical, vol. 370, pp. 115192-115192.
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Karp, T, Faiz, A, van Nijnatten, J, Kerstjens, HAM, Boudewijn, I, Kraft, M, Vonk, JM, Nawijn, MC, Heijink, IH, Beghé, B, Rabe, KF, Papi, A, Brightling, C, Singh, D, van der Molen, T, Siddiqui, S, Christenson, S, Guryev, V & van den Berge, M 2024, 'Nasal epithelial gene expression identifies relevant asthma endotypes in the ATLANTIS study', Thorax, vol. 79, no. 10, pp. 905-914.
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IntroductionAsthma is an inflammatory airways disease encompassing multiple phenotypes and endotypes. Several studies suggested gene expression in nasal epithelium to serve as a proxy for bronchial epithelium, being a non-invasive approach to investigate lung diseases. We hypothesised that molecular differences in upper airway epithelium reflect asthma-associated differences in the lower airways and are associated with clinical expression of asthma.MethodsWe analysed nasal epithelial gene expression data from 369 patients with asthma and 58 non-asthmatic controls from the Assessment of Small Airways Involvement in Asthma study. Unsupervised hierarchical clustering was performed on asthma-associated genes. Asthma-associated gene signatures were replicated in independent cohorts with nasal and bronchial brushes data by comparing Gene Set Variation Analysis scores between asthma patients and non-asthmatic controls.ResultsWe identified 67 higher expressed and 59 lower expressed genes in nasal epithelium from asthma patients compared with controls (false discovery rate<0.05), includingCLCA1, CST1andPOSTN, genes well known to reflect asthma in bronchial airway epithelium. Hierarchical clustering revealed several molecular asthma endotypes with distinct clinical characteristics, including an endotype with higher blood and sputum eosinophils, high fractional exhaled nitric oxide, and more severe small airway dysfunction, as reflected by lower forced expiratory flow at 50%. In an independent cohort, we demonstrated that genes higher expressed in the nasal epithelium reflect asthma-associated changes in the lower airways.ConclusionOur results show that the nasal epithelial gene e...
Khalenkow, D, Brandsma, C-A, Timens, W, Choy, DF, Grimbaldeston, MA, Rosenberger, CM, Slebos, D-J, Kerstjens, HAM, Faiz, A, Koppelman, GH, Nawijn, MC, van den Berge, M & Guryev, V 2024, 'Alternative Splicing Is a Major Factor Shaping Transcriptome Diversity in Mild and Severe Chronic Obstructive Pulmonary Disease', American Journal of Respiratory Cell and Molecular Biology, vol. 70, no. 5, pp. 414-423.
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Khan, K, Tareen, AK, Iqbal, M, Zhang, Y, Mahmood, A, mahmood, N, Shi, Z, Ma, C, Rosin, JR & Zhang, H 2024, 'Recent Progress and New Horizons in Emerging Novel MXene-Based Materials for Energy Storage Applications for Current Environmental Remediation and Energy Crises', Electrochemical Energy Reviews, vol. 7, no. 1.
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Kim, HT, Philip, L, McDonagh, A, Johir, M, Ren, J, Shon, HK & Tijing, LD 2024, 'Recent Advances in High‐Rate Solar‐Driven Interfacial Evaporation', Advanced Science, vol. 11, no. 26.
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AbstractRecent advances in solar‐driven interfacial evaporation (SDIE) have led to high evaporation rates that open promising avenues for practical utilization in freshwater production and industrial application for pollutant and nutrient concentration, and resource recovery. Breakthroughs in overcoming the theoretical limitation of 2D interfacial evaporation have allowed for developing systems with high evaporation rates. This study presents a comprehensive review of various evaporator designs that have achieved pure evaporation rates beyond 4 kg m−2 h−1, including structural and material designs allowing for rapid evaporation, passive 3D designs, and systems coupled with alternative energy sources of wind and joule heating. The operational mechanisms for each design are outlined together with discussion on the current benefits and areas for improvement. The overarching challenges encountered by SDIE concerning the feasibility of direct integration into contemporary practical settings are assessed, and issues relating to sustaining elevated evaporation rates under diverse environmental conditions are addressed.
Kim, J, Rose, ML, Pierce, JE, Nickels, L, Copland, DA, Togher, L, Godecke, E, Meinzer, M, Rai, T, Hurley, M, Foster, A, Carragher, M, Wilcox, C & Cadilhac, DA 2024, 'High-Intensity Aphasia Therapy Is Cost-Effective in People With Poststroke Aphasia: Evidence From the COMPARE Trial', Stroke, vol. 55, no. 3, pp. 705-714.
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BACKGROUND: Evidence from systematic reviews confirms that speech and language interventions for people with aphasia during the chronic phase after stroke (>6 months) improve word retrieval, functional communication, and communication-related quality of life. However, there is limited evidence of their cost-effectiveness. We aimed to estimate the cost per quality-adjusted life year gained from 2 speech and language therapies compared with usual care in people with aphasia during the chronic phase (median, 2.9 years) after stroke. METHODS: A 3-arm, randomized controlled trial compared constraint-induced aphasia therapy plus (CIAT-Plus) and multimodality aphasia therapy (M-MAT) with usual care in 216 people with chronic aphasia. Participants were administered a standardized questionnaire before intervention and at 12 weeks after the 2-week intervention/control period to ascertain health service utilization, employment changes, and informal caregiver burden. Unit prices from Australian sources were used to estimate costs in 2020. Quality-adjusted life years were estimated using responses to the EuroQol-5 Dimension-3 Level questionnaire. To test uncertainty around the differences in costs and outcomes between groups, bootstrapping was used with the cohorts resampled 1000 times. RESULTS: Overall 201/216 participants were included (mean age, 63 years, 29% moderate or severe aphasia, 61 usual care, 70 CIAT-Plus, 70 M-MAT). There were no statistically significant differences in mean total costs ($13 797 usual care, $17 478 CIAT-Plus, $11 113 M-MAT) and quality-adjusted life years (0.19 usual care, 0.20 CIAT-Plus, 0.20 M-MAT) between groups. In bootstrapped analysis of CIAT-Plus...
Kim, J, Sookram, G, Godecke, E, Brogan, E, Armstrong, E, Ellery, F, Rai, T, Rose, ML, Ciccone, N, Middleton, S, Holland, A, Hankey, GJ, Bernhardt, J & Cadilhac, DA 2024, 'Economic evaluation of the Very Early Rehabilitation in SpEech (VERSE) intervention', Topics in Stroke Rehabilitation, vol. 31, no. 2, pp. 157-166.
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Knights, AM, Lemasson, AJ, Firth, LB, Bond, T, Claisse, J, Coolen, JWP, Copping, A, Dannheim, J, De Dominicis, M, Degraer, S, Elliott, M, Fernandes, PG, Fowler, AM, Frost, M, Henry, L-A, Hicks, N, Hyder, K, Jagerroos, S, Jones, DOB, Love, M, Lynam, CP, Macreadie, PI, Marlow, J, Mavraki, N, McLean, D, Montagna, PA, Paterson, DM, Perrow, M, Porter, J, Russell, DJF, Bull, AS, Schratzberger, M, Shipley, B, van Elden, S, Vanaverbeke, J, Want, A, Watson, SCL, Wilding, TA & Somerfield, P 2024, 'Developing expert scientific consensus on the environmental and societal effects of marine artificial structures prior to decommissioning', Journal of Environmental Management, vol. 352, pp. 119897-119897.
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Kokkinis, S, De Rubis, G, Paudel, KR, Patel, VK, Yeung, S, Jessamine, V, MacLoughlin, R, Hansbro, PM, Oliver, B & Dua, K 2024, 'Liposomal curcumin inhibits cigarette smoke induced senescence and inflammation in human bronchial epithelial cells', Pathology - Research and Practice, vol. 260, pp. 155423-155423.
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Kokkinis, S, Paudel, KR, De Rubis, G, Yeung, S, Singh, M, Singh, SK, Gupta, G, Panth, N, Oliver, B & Dua, K 2024, 'Liposomal encapsulated curcumin attenuates lung cancer proliferation, migration, and induces apoptosis', Heliyon, vol. 10, no. 19, pp. e38409-e38409.
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Kokkinis, S, Singh, M, Paudel, KR, De Rubis, G, Bani Saeid, A, Jessamine, V, Datsyuk, J, Singh, SK, Vishwas, S, Adams, J, Hansbro, PM, Oliver, B, Gupta, G, Dureja, H & Dua, K 2024, 'Plant-based therapeutics for chronic obstructive pulmonary diseases: Nanoformulation strategies to overcome delivery challenges', Food Bioscience, vol. 58, pp. 103761-103761.
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Kumar Mondal, A, Hinkley, C, Kondaveeti, S, Vo, PHN, Ralph, P & Kuzhiumparambil, U 2024, 'Influence of pyrolysis time on removal of heavy metals using biochar derived from macroalgal biomass (Oedogonium sp.)', Bioresource Technology, vol. 414, pp. 131562-131562.
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Kumar, M, Ayzenshtat, D, Rather, GA, Zemach, H, Belausov, E, Eshed Williams, L & Bocobza, S 2024, 'A dynamic WUSCHEL/Layer 1 interplay directs shoot apical meristem formation during regeneration in tobacco', The Plant Journal, vol. 120, no. 2, pp. 578-597.
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SUMMARYDe novo shoot apical meristem (SAM) organogenesis during regeneration in tissue culture has been investigated for several decades, but the precise mechanisms governing early‐stage cell fate specification remain elusive. In contrast to SAM establishment during embryogenesis, in vitro SAM formation occurs without positional cues and is characterized by autonomous initiation of cellular patterning. Here, we report on the initial stages of SAM organogenesis and on the molecular mechanisms that orchestrate gene patterning to establish SAM homeostasis. We found that SAM organogenesis in tobacco calli starts with protuberance formation followed by the formation of an intact L1 layer covering the nascent protuberance. We also exposed a complex interdependent relationship between L1 and WUS expression and revealed that any disruption in this interplay compromises shoot formation. Silencing WUS in nascent protuberances prevented L1 formation and caused the disorganization of the outer cell layers exhibiting both anticlinal and periclinal divisions, suggesting WUS plays a critical role in the proper establishment and organization of L1 during SAM organogenesis. We further discovered that silencing TONNEAU1 prevents the exclusive occurrence of anticlinal divisions in the outermost layer of the protuberances and suppresses the acquisition of L1 cellular identity and L1 formation, ultimately impeding SAM formation and regeneration. This study provides a novel molecular framework for the characterization of a WUS/L1 interplay that mediates SAM formation during regeneration.
Kwak, ML, Wallman, JF, Yeo, D, Archer, MS & Nakao, R 2024, 'Forensic parasitology: a new frontier in criminalistics', Forensic Sciences Research, vol. 9, no. 2.
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Abstract Parasites are ubiquitous, diverse, and have close interactions with humans and other animals. Despite this, they have not garnered significant interest from forensic scientists, and their utility as indicators in criminal investigations has been largely overlooked. To foster the development of forensic parasitology we explore the utility of parasites as forensic indicators in five broad areas: (i) wildlife trafficking and exploitation, (ii) biological attacks, (iii) sex crimes, (iv) criminal neglect of humans and other animals, and (v) indicators of movement and travel. To encourage the development and growth of forensic parasitology as a field, we lay out a four-step roadmap to increase the use and utility of parasites in criminal investigations.
Lai, N, Chang, G, Yang, Y, He, M, Tang, W, Huang, Q, Zhang, Q, Su, QP, Liao, J, Yang, Y, Wang, C & Wang, R 2024, 'CsPbX3 quantum Dots@ZIF-8 composites with enhanced luminescence emission and stability', Journal of Luminescence, vol. 266, pp. 120280-120280.
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Lau, V, Spindler, X & Roux, C 2024, 'A dataset of textile fibres transferred between garments in a simulated assault for forensic interpretation and statistical analysis', Data in Brief, vol. 57, pp. 110992-110992.
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Lean, I, Zadoks, R, Brito, B & Golder, H 2024, 'Milk as a diagnostic fluid', Australian Veterinary Journal, vol. 102, no. 1-2, pp. 3-4.
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Leong, RC, Bugnot, AB, Ross, PM, Erickson, KR, Gibbs, MC, Marzinelli, EM, O'Connor, WA, Parker, LM, Poore, AGB, Scanes, E & Gribben, PE 2024, 'Recruitment of a threatened foundation oyster species varies with large and small spatial scales', Ecological Applications, vol. 34, no. 4.
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AbstractUnderstanding how habitat attributes (e.g., patch area and sizes, connectivity) control recruitment and how this is modified by processes operating at larger spatial scales is fundamental to understanding population sustainability and developing successful long‐term restoration strategies for marine foundation species—including for globally threatened reef‐forming oysters. In two experiments, we assessed the recruitment and energy reserves of oyster recruits onto remnant reefs of the oyster Saccostrea glomerata in estuaries spanning 550 km of coastline in southeastern Australia. In the first experiment, we determined whether recruitment of oysters to settlement plates in three estuaries was correlated with reef attributes within patches (distances to patch edges and surface elevation), whole‐patch attributes (shape and size of patches), and landscape attributes (connectivity). We also determined whether environmental factors (e.g., sedimentation and water temperature) explained the differences among recruitment plates. We also tested whether differences in energy reserves of recruits could explain the differences between two of the estuaries (one high‐ and one low‐sedimentation estuary). In the second experiment, across six estuaries (three with nominally high and three with nominally low sedimentation rates), we tested the hypothesis that, at the estuary scale, recruitment and survival were negatively correlated to sedimentation. Overall, total oyster recruitment varied mostly at the scale of estuaries rather than with reef attributes and was negatively correlated with sedimentation. Percentage recruit survival was, however, similar among estuaries, although energy reserves and condition of recruits were lower at a high‐ compared to a low‐sediment estuary. Within each estuary, total oyster recruitment increased with patch area and decreased with increasing tidal height. Our results sho...
Leslie, MN, Sheikh, Z, Xenaki, D, Oliver, BG, Young, PM, Traini, D & Ong, HX 2024, 'Repurposing nitrofurantoin as a stimulant of fibroblast extracellular matrix repair for the treatment of emphysema', Medicine in Drug Discovery, vol. 23, pp. 100194-100194.
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Letnic, M, Dempster, T, Jessop, TS & Webb, JK 2024, 'Imperfect adaptation by freshwater crocodiles to the invasion of a toxic prey species', Biological Invasions, vol. 26, no. 6, pp. 1941-1955.
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AbstractNovel interactions between invaders and native species that have evolved in their absence may impose strong selective pressures that drive species to extinction or prompt rapid co-evolution and learning. Here, we report on the effects that invasive cane toads, a toxic prey species, have had on freshwater crocodile populations in 7 waterholes of the Victoria River, Australia, before and up to 14 years after toads invaded. We recorded observations of crocodiles attacking toads, dissected dead crocodiles to determine if they had eaten toads and indexed the abundances of cane toads, live crocodiles and dead crocodiles. Following toad-invasion we observed crocodiles attacking cane toads. Dead crocodiles were only observed following the invasion of toads and 62% of the 71 dead crocodiles we dissected had toads in their stomachs. Counts of dead crocodiles showed a humped relationship with time since toad invasion and declined markedly after 3 years post-toad invasion. Live crocodile abundance declined sharply following toad-invasion, but this decline attenuated approximately 4 years post-invasion. The pulse of crocodile mortality and attenuation of the rate of crocodile population decline suggests that crocodiles have evolved or learned to enable co-existence with toads. However, crocodile populations have shown no sign of recovery in the 8–14 years post toad invasion. Our findings highlight that adaptation by native species to the presence of invaders may be imperfect and thus may not necessarily entail numerical recovery of populations to pre-invasion levels, but instead downward shifts to new equilibria due to ongoing interactions with invaders.
Lewis, JM, Jebeli, L, Coulon, PML, Lay, CE & Scott, NE 2024, 'Glycoproteomic and proteomic analysis of Burkholderia cenocepacia reveals glycosylation events within FliF and MotB are dispensable for motility', Microbiology Spectrum, vol. 12, no. 6.
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ABSTRACT Across the Burkholderia genus O -linked protein glycosylation is highly conserved. While the inhibition of glycosylation has been shown to be detrimental for virulence in Burkholderia cepacia complex species, such as Burkholderia cenocepacia , little is known about how specific glycosylation sites impact protein functionality. Within this study, we sought to improve our understanding of the breadth, dynamics, and requirement for glycosylation across the B. cenocepacia O- glycoproteome. Assessing the B. cenocepacia glycoproteome across different culture media using complementary glycoproteomic approaches, we increase the known glycoproteome to 141 glycoproteins. Leveraging this repertoire of glycoproteins, we quantitively assessed the glycoproteome of B. cenocepacia using Data-Independent Acquisition (DIA) revealing the B. cenocepacia glycoproteome is largely stable across conditions with most glycoproteins constitutively expressed. Examination of how the absence of glycosylation impacts the glycoproteome reveals that the protein abundance of only five glycoproteins (BCAL1086, BCAL2974, BCAL0525, BCAM0505, and BCAL0127) are altered by the loss of glycosylation. Assessing Δ fliF (ΔBCAL0525), Δ motB (ΔBCAL0127), and ΔBCAM0505 strains, we demonstrate the loss of FliF, and to a lesser extent MotB, mirror the proteomic effects observed in the absence of glycos...
Li, D, Jia, J, Zeng, H, Zhong, X, Chen, H & Yi, C 2024, 'Efficacy of exercise rehabilitation for managing patients with Alzheimer’s disease', Neural Regeneration Research, vol. 19, no. 10, pp. 2175-2188.
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Alzheimer’s disease (AD) is a progressive and degenerative neurological disease characterized by the deterioration of cognitive functions. While a definitive cure and optimal medication to impede disease progression are currently unavailable, a plethora of studies have highlighted the potential advantages of exercise rehabilitation for managing this condition. Those studies show that exercise rehabilitation can enhance cognitive function and improve the quality of life for individuals affected by AD. Therefore, exercise rehabilitation has been regarded as one of the most important strategies for managing patients with AD. Herein, we provide a comprehensive analysis of the currently available findings on exercise rehabilitation in patients with AD, with a focus on the exercise types which have shown efficacy when implemented alone or combined with other treatment methods, as well as the potential mechanisms underlying these positive effects. Specifically, we explain how exercise may improve the brain microenvironment and neuronal plasticity. In conclusion, exercise is a cost-effective intervention to enhance cognitive performance and improve quality of life in patients with mild to moderate cognitive dysfunction. Therefore, it can potentially become both a physical activity and a tailored intervention. This review may aid the development of more effective and individualized treatment strategies to address the challenges imposed by this debilitating disease, especially in low- and middle-income countries.
Li, J, Eagles, DA, Tucker, IJ, Pereira Schmidt, AC & Deplazes, E 2024, 'Secondary structure propensities of the Ebola delta peptide E40 in solution and model membrane environments', Biophysical Chemistry, vol. 314, pp. 107318-107318.
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Li, J, Gao, L, Pan, F, Gong, C, Sun, L, Gao, H, Zhang, J, Zhao, Y, Wang, G & Liu, H 2024, 'Engineering Strategies for Suppressing the Shuttle Effect in Lithium–Sulfur Batteries', Nano-Micro Letters, vol. 16, no. 1.
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AbstractLithium–sulfur (Li–S) batteries are supposed to be one of the most potential next-generation batteries owing to their high theoretical capacity and low cost. Nevertheless, the shuttle effect of firm multi-step two-electron reaction between sulfur and lithium in liquid electrolyte makes the capacity much smaller than the theoretical value. Many methods were proposed for inhibiting the shuttle effect of polysulfide, improving corresponding redox kinetics and enhancing the integral performance of Li–S batteries. Here, we will comprehensively and systematically summarize the strategies for inhibiting the shuttle effect from all components of Li–S batteries. First, the electrochemical principles/mechanism and origin of the shuttle effect are described in detail. Moreover, the efficient strategies, including boosting the sulfur conversion rate of sulfur, confining sulfur or lithium polysulfides (LPS) within cathode host, confining LPS in the shield layer, and preventing LPS from contacting the anode, will be discussed to suppress the shuttle effect. Then, recent advances in inhibition of shuttle effect in cathode, electrolyte, separator, and anode with the aforementioned strategies have been summarized to direct the further design of efficient materials for Li–S batteries. Finally, we present prospects for inhibition of the LPS shuttle and potential development directions in Li–S batteries.
Li, J, Hao, J, Yuan, Q, Wang, R, Marlton, F, Wang, T, Wang, C, Guo, X & Wang, G 2024, 'The effect of salt anion in ether‐based electrolyte for electrochemical performance of sodium‐ion batteries: A case study of hard carbon', Carbon Energy, vol. 6, no. 8.
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AbstractCompared with the extensively used ester‐based electrolyte, the hard carbon (HC) electrode is more compatible with the ether‐based counterpart in sodium‐ion batteries, which can lead to improved cycling stability and robust rate capability. However, the impact of salt anion on the electrochemical performance of HC electrodes has yet to be fully understood. In this study, the anionic chemistry in regulating the stability of electrolytes and the performance of sodium‐ion batteries have been systematically investigated. This work shows discrepancies in the reductive stability of the anionic group, redox kinetics, and component/structure of solid electrolyte interface (SEI) with different salts (NaBF4, NaPF6, and NaSO3CF3) in the typical ether solvent (diglyme). Particularly, the density functional theory calculation manifests the preferred decomposition of PF6− due to the reduced reductive stability of anions in the solvation structure, thus leading to the formation of NaF‐rich SEI. Further investigation on redox kinetics reveals that the NaPF6/diglyme can induce the fast ionic diffusion dynamic and low charge transfer barrier for HC electrode, thus resulting in superior sodium storage performance in terms of rate capability and cycling life, which outperforms those of NaBF4/diglyme and NaSO3CF3/diglyme. Importantly, this work offers valuable insights for optimizing the electrochemical behaviors of electrode materials by regulating the anionic group in the electrolyte.
Li, K, Akkaya-Hocagil, T, Cook, RJ, Ryan, LM, Carter, RC, Dang, K-D, Jacobson, JL & Jacobson, SW 2024, 'Use of Generalized Propensity Scores for Assessing Effects of Multiple Exposures', Statistics in Biosciences, vol. 16, no. 2, pp. 347-376.
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Li, S, Wang, B, Liu, DL, Chen, C, Feng, P, Huang, M, Wang, X, Shi, L, Waters, C, Huete, A & Yu, Q 2024, 'Can agronomic options alleviate the risk of compound drought-heat events during the wheat flowering period in southeastern Australia?', European Journal of Agronomy, vol. 153, pp. 127030-127030.
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Li, Y, Hu, D, Kong, M, Gu, Y, Zhou, Z, Shi, M, Zhang, G & Feng, W 2024, 'A NIR-to-NIR non-emissive rare-earth nanoprobe that specifically lights-up inflammatory condition in vivo', Journal of Rare Earths.
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Liddell, JR, Hilton, JBW, Wang, YJ, Billings, JL, Nikseresht, S, Kysenius, K, Fuller-Jackson, JP, Hare, DJ & Crouch, PJ 2024, 'Decreased spinal cord motor neuron numbers in mice depleted of central nervous system copper', Metallomics, vol. 16, no. 9.
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Abstract Disrupted copper availability in the central nervous system (CNS) is implicated as a significant feature of the neurodegenerative disease amyotrophic lateral sclerosis (ALS). Solute carrier family 31 member 1 (Slc31a1; Ctr1) governs copper uptake in mammalian cells and mutations affecting Slc31a1 are associated with severe neurological abnormalities. Here, we examined the impact of decreased CNS copper caused by ubiquitous heterozygosity for functional Slc31a1 on spinal cord motor neurons in Slc31a1+/− mice. Congruent with the CNS being relatively susceptible to disrupted copper availability, brain and spinal cord tissue from Slc31a1+/− mice contained significantly less copper than wild-type littermates, even though copper levels in other tissues were unaffected. Slc31a1+/− mice had less spinal cord α-motor neurons compared to wild-type littermates, but they did not develop any overt physical signs of motor impairment. By contrast, ALS model SOD1G37R mice had fewer α-motor neurons than control mice and exhibited clear signs of motor function impairment. With the expression of Slc31a1 notwithstanding, spinal cord expression of genes related to copper handling revealed only minor differences between Slc31a1+/− and wild-type mice. This contrasted with SOD1G37R mice where changes in the expression of copper handling genes were pronounced. Similarly, the expression of genes related to toxic glial activation was unchanged in spinal cords from Slc31a1+/− mice but highly upregulated in SOD1G37R mice. Together, results from the Slc31a1+/− mice and SOD1G37R mice indicate that although depleted CNS copper has a significant impact on spinal cord motor neuron numbers, the manifestation of overt ALS-like motor impairment requires additional factors.
Lim, CED & Chen, H 2024, 'Awareness of and barriers to participating in the national bowel cancer screening program among Chinese Australians', The Australian Journal of General Practice, vol. 53, no. 6.
Lim, CED, Sanchez, C & Chen, H 2024, 'Light in the darkness – accessibility to palliative care for cancer patients of Chinese background and their families', Journal of Primary Health Care.
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Liu, C, Wan, T, Guan, P, Li, M, Zhang, S, Hu, L, Kuo, Y, Feng, Z, Chen, F, Zhu, Y, Jia, H, Cao, T, Liang, T, Kumeria, T, Su, D & Chu, D 2024, 'Unveil the Triple Roles of Water Molecule on Power Generation of MXene Derived TiO2 based Moisture Electric Generator', Advanced Energy Materials, vol. 14, no. 27.
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AbstractEvaporation‐driven electricity generators have been proposed to generate electricity by water interacting with nanostructured materials. However, several proposed mechanisms, such as intrinsic gradient of polar functional groups principle and electrokinetic effect perspective, are in wide discrepancy. Here, through the combination of theoretical calculations involving time dimension on material's moisturizing process and experimental analyses, it is revealed the working principle through the water molecule triple roles in driving moisture electric generators (MEGs): 1) intrinsic H2O absorption on the material surface and splitting into hydroxy group and proton due to the polarizability of the material surface determined by the static electric potential of the materials. This process induces the electrochemical potential difference of the materials via the work function changes; 2) freely diffused protons derived from the H2O splitting work as the ions charge carriers; 3) via the hydrogen bond of the water molecules to drive charge carriers diffuse between opposite electrodes, maintaining the internal circuit current flow. It is successfully unveiled that anatase TiO2 based materials for output voltage changes correlated to the domains’ work function's difference, tuning by the surface adsorption species (H, Cl, OH) and anisotropic exposed crystal facets of the material. This work unveils MEG's general working principle.
Liu, C, Ye, C, Zhang, T, Tang, J, Mao, K, Chen, L, Xue, L, Sun, J, Zhang, W, Wang, X, Xiong, P, Wang, G & Zhu, J 2024, 'Bio‐inspired Double Angstrom‐Scale Confinement in Ti‐deficient Ti0.87O2 Nanosheet Membranes for Ultrahigh‐performance Osmotic Power Generation', Angewandte Chemie International Edition, vol. 63, no. 4.
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AbstractOsmotic power, a clean energy source, can be harvested from the salinity difference between seawater and river water. However, the output power densities are hampered by the trade‐off between ion selectivity and ion permeability. Here we propose an effective strategy of double angstrom‐scale confinement (DAC) to design ion‐permselective channels with enhanced ion selectivity and permeability simultaneously. The fabricated DAC‐Ti0.87O2 membranes possess both Ti atomic vacancies and an interlayer free spacing of ≈2.2 Å, which not only generates a profitable confinement effect for Na+ ions to enable high ion selectivity but also induces a strong interaction with Na+ ions to benefit high ion permeability. Consequently, when applied to osmotic power generation, the DAC‐Ti0.87O2 membranes achieved an ultrahigh power density of 17.8 W m−2 by mixing 0.5/0.01 M NaCl solution and up to 114.2 W m−2 with a 500‐fold salinity gradient, far exceeding all the reported macroscopic‐scale membranes. This work highlights the potential of the construction of DAC ion‐permselective channels for two‐dimensional materials in high‐performance nanofluidic energy systems.
Liu, C, Ye, C, Zhang, T, Tang, J, Mao, K, Chen, L, Xue, L, Sun, J, Zhang, W, Wang, X, Xiong, P, Wang, G & Zhu, J 2024, 'Bio‐inspired Double Angstrom‐Scale Confinement in Ti‐deficient Ti0.87O2 Nanosheet Membranes for Ultrahigh‐performance Osmotic Power Generation', Angewandte Chemie, vol. 136, no. 4.
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AbstractOsmotic power, a clean energy source, can be harvested from the salinity difference between seawater and river water. However, the output power densities are hampered by the trade‐off between ion selectivity and ion permeability. Here we propose an effective strategy of double angstrom‐scale confinement (DAC) to design ion‐permselective channels with enhanced ion selectivity and permeability simultaneously. The fabricated DAC‐Ti0.87O2 membranes possess both Ti atomic vacancies and an interlayer free spacing of ≈2.2 Å, which not only generates a profitable confinement effect for Na+ ions to enable high ion selectivity but also induces a strong interaction with Na+ ions to benefit high ion permeability. Consequently, when applied to osmotic power generation, the DAC‐Ti0.87O2 membranes achieved an ultrahigh power density of 17.8 W m−2 by mixing 0.5/0.01 M NaCl solution and up to 114.2 W m−2 with a 500‐fold salinity gradient, far exceeding all the reported macroscopic‐scale membranes. This work highlights the potential of the construction of DAC ion‐permselective channels for two‐dimensional materials in high‐performance nanofluidic energy systems.
Liu, T, Zhang, W, Wang, L, Ueland, M, Forbes, SL, Zheng, WX & Su, SW 2024, 'Numerical Differentiation From Noisy Signals: A Kernel Regularization Method to Improve Transient-State Features for the Electronic Nose', IEEE Transactions on Systems, Man, and Cybernetics: Systems, vol. 54, no. 6, pp. 3497-3511.
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Liu, Y, Ning, L, Luo, Y, Huang, Y, He, Z, Ma, H, Zhao, Y, Zhang, J, Liu, D, Fu, L, Langford, SJ, Gale, PA, Luo, Y & Bao, G 2024, 'Stabilizing Dye-Sensitized Upconversion Hybrids by Cyclooctatetraene', Nano Letters, vol. 24, no. 40, pp. 12486-12492.
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Lanthanide-doped upconversion nanoparticles (UCNPs) can convert low-energy near-infrared (NIR) light into high-energy visible light, making them valuable for broad applications. UCNPs often suffer from poor light-harvesting capabilities, which can be significantly improved by incorporating organic dye antennas. However, the dye-sensitized upconversion systems are prone to severe photobleaching in an ambient atmosphere. Here, we present a synergistic approach to mitigate photobleaching by introducing triplet state quencher cyclooctatetraene (COT). COT effectively suppresses the generation of singlet oxygen by quenching the triplet states of the dye and consumes the existing singlet oxygen through oxidant reactions. The inclusion of COT extends the half-life of IR806 by 4.7-times by preventing the oxidation of its poly(methylene) chains. Without significantly affecting emission intensity and dynamics, COT effectively stabilized dye-UCNPs, demonstrating a notable 3.9-fold increase in half-life under continuous laser irradiation. Our findings suggest a new strategy to enhance the photostability of near-infrared dyes and dye-sensitized upconversion nanohybrids.
Liu, Y, Qi, Q, Jiang, Y, Zhao, P, Chen, L, Ma, X, Shi, Y, Xu, J, Li, J, Chen, F, Chen, J, Zhang, L, Wu, Y, Jiang, X, Jin, D, Xu, T & Bu, W 2024, 'Ion Current Rectification Activity Induced by Boron Hydride Nanosheets to Enhance Magnesium Analgesia', Angewandte Chemie, vol. 136, no. 34.
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AbstractThe limited analgesic efficiency of magnesium restricts its application in pain management. Here, we report boron hydride (BH) with ion currents rectification activity that can enhance the analgesic efficiency of magnesium without the risks of drug tolerance or addiction. We synthesize MgB2, comprising hexagonal boron sheets alternating with Mg2+. In pathological environment, Mg2+ is exchanged by H+, forming two‐dimensional borophene‐analogue BH sheets. BH interacts with the charged cations via cation‐pi interaction, leading to dynamic modulation of sodium and potassium ion currents around neurons. Additionally, released Mg2+ competes Ca2+ to inhibit its influx and neuronal excitation. In vitro cultured dorsal root neurons show a remarkable increase in threshold potential from the normal −35.9 mV to −5.9 mV after the addition of MgB2, indicating potent analgesic effect. In three typical pain models, including CFA‐induced inflammatory pain, CINP‐ or CCI‐induced neuropathic pain, MgB2 exhibits analgesic efficiency approximately 2.23, 3.20, and 2.0 times higher than clinical MgSO4, respectively, and even about 1.04, 1.66, and 1.95 times higher than morphine, respectively. The development of magnesium based intermetallic compounds holds promise in addressing the non‐opioid medical need for pain relief.
Liu, Y, Qi, Q, Jiang, Y, Zhao, P, Chen, L, Ma, X, Shi, Y, Xu, J, Li, J, Chen, F, Chen, J, Zhang, L, Wu, Y, Jiang, X, Jin, D, Xu, T & Bu, W 2024, 'Ion Current Rectification Activity Induced by Boron Hydride Nanosheets to Enhance Magnesium Analgesia', Angewandte Chemie International Edition, vol. 63, no. 34.
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AbstractThe limited analgesic efficiency of magnesium restricts its application in pain management. Here, we report boron hydride (BH) with ion currents rectification activity that can enhance the analgesic efficiency of magnesium without the risks of drug tolerance or addiction. We synthesize MgB2, comprising hexagonal boron sheets alternating with Mg2+. In pathological environment, Mg2+ is exchanged by H+, forming two‐dimensional borophene‐analogue BH sheets. BH interacts with the charged cations via cation‐pi interaction, leading to dynamic modulation of sodium and potassium ion currents around neurons. Additionally, released Mg2+ competes Ca2+ to inhibit its influx and neuronal excitation. In vitro cultured dorsal root neurons show a remarkable increase in threshold potential from the normal −35.9 mV to −5.9 mV after the addition of MgB2, indicating potent analgesic effect. In three typical pain models, including CFA‐induced inflammatory pain, CINP‐ or CCI‐induced neuropathic pain, MgB2 exhibits analgesic efficiency approximately 2.23, 3.20, and 2.0 times higher than clinical MgSO4, respectively, and even about 1.04, 1.66, and 1.95 times higher than morphine, respectively. The development of magnesium based intermetallic compounds holds promise in addressing the non‐opioid medical need for pain relief.
Liu, Z, Sun, B, Zhang, Y, Zhang, Q & Fan, L 2024, 'Polymer-adjusted zinc anode towards high-performance aqueous zinc ion batteries', Progress in Polymer Science, vol. 152, pp. 101817-101817.
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Lockwood, TE, Banati, RB, Nikagolla, C, Violi, JP & Bishop, DP 2024, 'Concentration and Distribution of Toxic and Essential Elements in Traditional Rice Varieties of Sri Lanka Grown on an Anuradhapura District Farm', Biological Trace Element Research, vol. 202, no. 6, pp. 2891-2899.
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AbstractToxic heavy metals have been the focus of many investigations into chronic kidney disease of unknown aetiology (CKDu) within Sri Lanka. It has been hypothesised that exposure to nephrotoxic arsenic, cadmium and lead could play a role in the development of CKDu, and these metals have previously been found in unsafe concentrations in Sri Lankan rice. Traditional varieties of Sri Lankan rice remain popular due to their perceived health benefits, but their uptake of trace and toxic heavy metals remained unexplored. Here, we report a one-time, cross-sectional dataset on the concentrations of essential and toxic elements present in eleven samples of polished and unpolished traditional rice varieties, all regularly grown and sold in the Anuradhapura district, a CKDu hotspot. All rice was sourced from the same farm, with the exception of one store bought sample grown on another, unidentified farm. Cadmium concentrations varied significantly between varieties, and potentially unsafe concentrations of cadmium were detected in the store-bought sample (Suwadel, 113±13 μg kg−1). Elemental imaging of the grains revealed lead to be stored mainly in the rice bran, which is removed during polishing, while cadmium was distributed in the edible portion of the grain. Essential elements were generally higher in the traditional rice varieties than those reported for non-traditional varieties and are a potential source of trace elements for nutrient-deficient communities. The concentration of selenium, an element that plays a protective role in the kidneys, was too low to provide the minimum recommended intake. The methods developed in this study could be applied to a more comprehensive study of elemental uptake of rice under controlled growing conditions.
Lu, J, Wang, T, Yang, J, Shen, X, Pang, H, Sun, B, Wang, G & Wang, C 2024, 'Multifunctional Self‐Assembled Bio‐Interfacial Layers for High‐Performance Zinc Metal Anodes', Angewandte Chemie, vol. 136, no. 42.
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AbstractRechargeable aqueous zinc‐ion (Zn‐ion) batteries are widely regarded as important candidates for next‐generation energy storage systems for low‐cost renewable energy storage. However, the development of Zn‐ion batteries is currently facing significant challenges due to uncontrollable Zn dendrite growth and severe parasitic reactions on Zn metal anodes. Herein, we report an effective strategy to improve the performance of aqueous Zn‐ion batteries by leveraging the self‐assembly of bovine serum albumin (BSA) into a bilayer configuration on Zn metal anodes. BSA′s hydrophilic and hydrophobic fragments form unique and intelligent ion channels, which regulate the migration of Zn ions and facilitate their desolvation process, significantly diminishing parasitic reactions on Zn anodes and leading to a uniform Zn deposition along the Zn (002) plane. Notably, the Zn||Zn symmetric cell with BSA as the electrolyte additive demonstrated a stable cycling performance for up to 2400 hours at a high current density of 10 mA cm−2. This work demonstrates the pivotal role of self‐assembled protein bilayer structures in improving the durability of Zn anodes in aqueous Zn‐ion batteries.
Luong, HA, Rohlfs, A-M, Facey, JA, Colville, A & Mitrovic, SM 2024, 'Long-term study of phytoplankton dynamics in a supply reservoir reveals signs of trophic state shift linked to changes in hydrodynamics associated with flow management and extreme events', Water Research, vol. 256, pp. 121547-121547.
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Ma, J, Chen, Y, Li, T, Cao, Y, Hu, B, Liu, Y, Zhang, Y, Li, X, Liu, J, Zhang, W, Niu, H, Gao, J, Zhang, Z, Yue, K, Wang, J, Bao, G, Wang, C, Wang, PG, Zou, T & Xie, S 2024, 'Suppression of lysosome metabolism-meditated GARP/TGF-β1 complexes specifically depletes regulatory T cells to inhibit breast cancer metastasis', Oncogene, vol. 43, no. 25, pp. 1930-1940.
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Ma, J, Zhang, J, Horder, J, Sukhorukov, AA, Toth, M, Neshev, DN & Aharonovich, I 2024, 'Engineering Quantum Light Sources with Flat Optics', Advanced Materials, vol. 36, no. 23.
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AbstractQuantum light sources are essential building blocks for many quantum technologies, enabling secure communication, powerful computing, and precise sensing and imaging. Recent advancements have witnessed a significant shift toward the utilization of “flat” optics with thickness at subwavelength scales for the development of quantum light sources. This approach offers notable advantages over conventional bulky counterparts, including compactness, scalability, and improved efficiency, along with added functionalities. This review focuses on the recent advances in leveraging flat optics to generate quantum light sources. Specifically, the generation of entangled photon pairs through spontaneous parametric down‐conversion in nonlinear metasurfaces, and single photon emission from quantum emitters including quantum dots and color centers in 3D and 2D materials are explored. The review covers theoretical principles, fabrication techniques, and properties of these sources, with particular emphasis on the enhanced generation and engineering of quantum light sources using optical resonances supported by nanostructures. The diverse application range of these sources is discussed and the current challenges and perspectives in the field are highlighted.
Macaulay, M & Fourment, M 2024, 'Differentiable phylogenetics via hyperbolic embeddings with Dodonaphy', Bioinformatics Advances, vol. 4, no. 1.
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Abstract Motivation Navigating the high dimensional space of discrete trees for phylogenetics presents a challenging problem for tree optimization. To address this, hyperbolic embeddings of trees offer a promising approach to encoding trees efficiently in continuous spaces. However, they require a differentiable tree decoder to optimize the phylogenetic likelihood. We present soft-NJ, a differentiable version of neighbour joining that enables gradient-based optimization over the space of trees. Results We illustrate the potential for differentiable optimization over tree space for maximum likelihood inference. We then perform variational Bayesian phylogenetics by optimizing embedding distributions in hyperbolic space. We compare the performance of this approximation technique on eight benchmark datasets to state-of-the-art methods. Results indicate that, while this technique is not immune from local optima, it opens a plethora of powerful and parametrically efficient approach to phylogenetics via tree embeddings. Availability and implementation Dodonaphy is freely available on the web at https://www.github.com/mattapow/dodonaphy. It includes an implementation of soft-NJ.
Maestrini, L, Bhaskaran, A & Wand, MP 2024, 'Second term improvement to generalized linear mixed model asymptotics', Biometrika, vol. 111, no. 3, pp. 1077-1084.
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Abstract A recent article by Jiang et al. (2022) on generalized linear mixed model asymptotics derived the rates of convergence for the asymptotic variances of maximum likelihood estimators. If m denotes the number of groups and n is the average within-group sample size then the asymptotic variances have orders m−1 and (mn)−1, depending on the parameter. We extend this theory to provide explicit forms of the (mn)−1 second terms of the asymptotically harder-to-estimate parameters. Improved accuracy of statistical inference and planning are consequences of our theory.
Mahmodi, H, Poulton, CG, Leslie, MN, Oldham, G, Ong, HX, Langford, SJ & Kabakova, IV 2024, 'Principal component analysis in application to Brillouin microscopy data', Journal of Physics: Photonics, vol. 6, no. 2, pp. 025009-025009.
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Abstract Brillouin microscopy has recently emerged as a new bio-imaging modality that provides information on the microscale mechanical properties of biological materials, cells and tissues. The data collected in a typical Brillouin microscopy experiment represents the high-dimensional set of spectral information, i.e. each pixel within a 2D/3D Brillouin image is associated with hundreds of points of spectral data. Its analysis requires non-trivial approaches due to subtlety in spectral variations as well as spatial and spectral overlaps of measured features. This article offers a guide to the application of Principal Component Analysis (PCA) for processing Brillouin imaging data. Being unsupervised multivariate analysis, PCA is well-suited to tackle processing of complex Brillouin spectra from heterogeneous biological samples with minimal a priori information requirements. We point out the importance of data pre-processing steps in order to improve outcomes of PCA. We also present a strategy where PCA combined with k-means clustering method can provide a working solution to data reconstruction and deeper insights into sample composition, structure and mechanics.
Mahmood, A, Zheng, Z & Chen, Y 2024, 'Zinc–Bromine Batteries: Challenges, Prospective Solutions, and Future', Advanced Science, vol. 11, no. 3, p. e2305561.
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AbstractZinc‐bromine batteries (ZBBs) have recently gained significant attention as inexpensive and safer alternatives to potentially flammable lithium‐ion batteries. Zn metal is relatively stable in aqueous electrolytes, making ZBBs safer and easier to handle. However, Zn metal anodes are still affected by several issues, including dendrite growth, Zn dissolution, and the crossover of Br species from cathodes to corrode anodes, resulting in self‐discharge and fast performance fading. Similarly, Br2 undergoes sluggish redox reactions on cathodes, which brings several issues such as poor reaction kinetics, the highly corrosive nature of Br species leading to corrosion of separators and poisoning of anodes, and the volatile nature of Br species causing increased internal pressures, etc. These issues are compounded in flowless ZBB configuration as no fresh electrolyte is available to provide extra/fresh reaction species. In this review, the factors controlling the performance of ZBBs in flow and flowless configurations are thoroughly reviewed, along with the status of ZBBs in the commercial sector. The review also summarizes various novel methodologies to mitigate these challenges and presents research areas for future studies. In summary, this review will offer a perspective on the historical evolution, recent advancements, and prospects of ZBBs.
Mai, TNA, Ali, S, Hossain, MS, Chen, C, Ding, L, Chen, Y, Solntsev, AS, Mou, H, Xu, X, Medhekar, N & Tran, TT 2024, 'Cryogenic Thermal Shock Effects on Optical Properties of Quantum Emitters in Hexagonal Boron Nitride', ACS Applied Materials & Interfaces, vol. 16, no. 15, pp. 19340-19349.
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Solid-state quantum emitters are vital building blocks for quantum information science and quantum technology. Among various types of solid-state emitters discovered to date, color centers in hexagonal boron nitride have garnered tremendous traction in recent years, thanks to their environmental robustness, high brightness, and room-temperature operation. Most recently, these quantum emitters have been employed for satellite-based quantum key distribution. One of the most important requirements to qualify these emitters for space-based applications is their optical stability against cryogenic thermal shock. Such an understanding has, however, remained elusive to date. Here, we report on the effects caused by such thermal shock that induces random, irreversible changes in the spectral characteristics of the quantum emitters. By employing a combination of structural characterizations and density functional calculations, we attribute the observed changes to lattice strain caused by cryogenic temperature shock. Our study sheds light on the stability of the quantum emitters under extreme conditions─similar to those countered in outer space.
Majzoub, ME, Luu, LDW, Haifer, C, Paramsothy, S, Borody, TJ, Leong, RW, Thomas, T & Kaakoush, NO 2024, 'Refining microbial community metabolic models derived from metagenomics using reference-based taxonomic profiling', mSystems, vol. 9, no. 9.
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ABSTRACT Characterization of microbial community metabolic output is crucial to understanding their functions. Construction of genome-scale metabolic models from metagenome-assembled genomes (MAG) has enabled prediction of metabolite production by microbial communities, yet little is known about their accuracy. Here, we examined the performance of two approaches for metabolite prediction from metagenomes, one that is MAG-guided and another that is taxonomic reference-guided. We applied both on shotgun metagenomics data from human and environmental samples, and validated findings in the human samples using untargeted metabolomics. We found that in human samples, where taxonomic profiling is optimized and reference genomes are readily available, when number of input taxa was normalized, the reference-guided approach predicted more metabolites than the MAG-guided approach. The two approaches showed significant overlap but each identified metabolites not predicted in the other. Pathway enrichment analyses identified significant differences in inferences derived from data based on the approach, highlighting the need for caution in interpretation. In environmental samples, when the number of input taxa was normalized, the reference-guided approach predicted more metabolites than the MAG-guided approach for total metabolites in both sample types and non-redundant metabolites in seawater samples. Nonetheless, as was observed for the human samples, the approaches overlapped substantially but also predicted metabolites not observed in the other. Our findings report on utility of a complementary input to genome-scale metabolic model construction that is less computationally intensive forgoing MAG assembly and refinement, and that can be applied on shallow shotgun sequencing where MAGs cannot be generated. IMPORTANCE<...
Mamun, SMN, Kumar Paul, D, Matar, F, Ton-That, C & Rahman, MA 2024, 'Zinc Dopant-Induced Modulation of Electronic Structure and Defect Emissions in Monoclinic Gallium Oxide', The Journal of Physical Chemistry C, vol. 128, no. 11, pp. 4722-4728.
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Manandhar, B, Paudel, KR, Clarence, DD, De Rubis, G, Madheswaran, T, Panneerselvam, J, Zacconi, FC, Williams, KA, Pont, LG, Warkiani, ME, MacLoughlin, R, Oliver, BG, Gupta, G, Singh, SK, Chellappan, DK, Hansbro, PM & Dua, K 2024, 'Zerumbone-incorporated liquid crystalline nanoparticles inhibit proliferation and migration of non-small-cell lung cancer in vitro', Naunyn-Schmiedeberg's Archives of Pharmacology, vol. 397, no. 1, pp. 343-356.
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AbstractLung cancer is the second most prevalent type of cancer and is responsible for the highest number of cancer-related deaths worldwide. Non-small-cell lung cancer (NSCLC) makes up the majority of lung cancer cases. Zerumbone (ZER) is natural compound commonly found in the roots ofZingiber zerumbetwhich has recently demonstrated anti-cancer activity in both in vitro and in vivo studies. Despite their medical benefits, ZER has low aqueous solubility, poor GI absorption and oral bioavailability that hinders its effectiveness. Liquid crystalline nanoparticles (LCNs) are novel drug delivery carrier that have tuneable characteristics to enhance and ease the delivery of bioactive compounds. This study aimed to formulate ZER-loaded LCNs and investigate their effectiveness against NSCLC in vitro using A549 lung cancer cells. ZER-LCNs, prepared in the study, inhibited the proliferation and migration of A549 cells. These inhibitory effects were superior to the effects of ZER alone at a concentration 10 times lower than that of free ZER, demonstrating a potent anti-cancer activity of ZER-LCNs. The underlying mechanisms of the anti-cancer effects by ZER-LCNs were associated with the transcriptional regulation of tumor suppressor genesP53andPTEN, and metastasis-associated geneKRT18. The protein array data showed downregulation of several proliferation associated proteins such as AXL, HER1, PGRN, and BIRC5 and metastasis-associated proteins such as DKK1, CAPG, CTSS, CTSB, CTSD, and PLAU. This study provides evidence of potential for increasing the potency and effectiveness of ZER with LCN formulation and developing ZER-LCNs as a treatment strategy for mitigation and treatment of NSCLC.
Marlton, FP, Yang, FZT, Everett, SM, Neuefeind, J & Schmid, S 2024, 'Understanding the influence of local structure distortions on Na-ion migration in perovskite solid electrolytes', Journal of Power Sources, vol. 617, pp. 235154-235154.
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Marsh, DJ, Mulligan, LM, Ngeow, J, Ringel, MD & Stratakis, CA 2024, 'In Memoriam: Charis Eng, M.D., Ph.D. (1962-2024)', Endocrine-Related Cancer.
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Matthew Ringel On behalf of the entire editorial team of Endocrine-Related Cancer, and personally as trainees and collaborators who at present serve as associate or senior editors of the Journal, it is with profound sadness that we write this memorial to Prof. Charis Eng, M.D., Ph.D who passed away on August 13, 2024. Prof. Eng served as Editor-in-Chief of Endocrine-Related Cancer from 2011-2021 and was dedicated to the Journal before, during, and after she served in that role. She had remarkable impact on Endocrine-Related Cancer moving the journal forward with great vision and energy while maintaining the strongest commitments to publishing the highest quality original research and reviews applying fair, ethical, and rigorous peer-review processes. Charis was a world-recognized leader in cancer genomics and clinical genetics medicine who enabled growth in Endocrine-Related Cancer in these and other areas critical for advancement of research and clinical care of endocrine cancers. She will be remembered by all of us as a superb and consequential researcher, editor, physician, leader, teacher, mentor, colleague, and friend.
Matheson, S, Fleck, R, Lockwood, T, Gill, RL, Lyu, L, Irga, PJ & Torpy, FR 2024, 'Fuel fumes and foliage: the fate of speciated gasoline VOCs during phytoremediation and their impact on the bacterial phenotype', Environmental Pollution, pp. 125199-125199.
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McClements, L, Pienaar, D, Chen, H, Gentile, C, Padula, M, McGrath, KC, Henry, A, Ghorbanpour, S, Margaret Roberts, L & Liu Chung Ming, C 2024, 'New 3D cardiac in vitro models for assessing the maternal cardiovascular health five years post hypertensive disorders of pregnancy', Pregnancy Hypertension, vol. 36, pp. 15-16.
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McClements, L, Richards, C, Bakrania, B, Owen, G, Zhand, S, Huyen Phan, T, Lei, Q, McGrath, K & Chrzanowski, W 2024, 'Bioprinting a placental model to study the effects of current and emerging treatments of preeclampsia', Pregnancy Hypertension, vol. 36, pp. 5-5.
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McKnight, DJE, Wong-Bajracharya, J, Okoh, EB, Snijders, F, Lidbetter, F, Webster, J, Haughton, M, Darling, AE, Djordjevic, SP, Bogema, DR & Chapman, TA 2024, 'Xanthomonas rydalmerensis sp. nov., a non-pathogenic member of Group 1 Xanthomonas', International Journal of Systematic and Evolutionary Microbiology, vol. 74, no. 3.
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Five bacterial isolates were isolated from Fragaria × ananassa in 1976 in Rydalmere, Australia, during routine biosecurity surveillance. Initially, the results of biochemical characterisation indicated that these isolates represented members of the genus Xanthomonas. To determine their species, further analysis was conducted using both phenotypic and genotypic approaches. Phenotypic analysis involved using MALDI-TOF MS and BIOLOG GEN III microplates, which confirmed that the isolates represented members of the genus Xanthomonas but did not allow them to be classified with respect to species. Genome relatedness indices and the results of extensive phylogenetic analysis confirmed that the isolates were members of the genus Xanthomonas and represented a novel species. On the basis the minimal presence of virulence-associated factors typically found in genomes of members of the genus Xanthomonas, we suggest that these isolates are non-pathogenic. This conclusion was supported by the results of a pathogenicity assay. On the basis of these findings, we propose the name Xanthomonas rydalmerensis, with DAR 34855T = ICMP 24941 as the type strain.
Meakin, GE, Jacques, GS & Morgan, RM 2024, 'Comparison of DNA recovery methods and locations from regularly-worn hooded jumpers before and after use by a second wearer', Science & Justice, vol. 64, no. 2, pp. 232-242.
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Medhavy, A, Athanasopoulos, V, Bassett, K, He, Y, Stanley, M, Enosi Tuipulotu, D, Cappello, J, Brown, GJ, Gonzalez-Figueroa, P, Turnbull, C, Shanmuganandam, S, Tummala, P, Hart, G, Lea-Henry, T, Wang, H, Nambadan, S, Shen, Q, Roco, JA, Burgio, G, Wu, P, Cho, E, Andrews, TD, Field, MA, Wu, X, Ding, H, Guo, Q, Shen, N, Man, SM, Jiang, SH, Cook, MC & Vinuesa, CG 2024, 'A TNIP1-driven systemic autoimmune disorder with elevated IgG4', Nature Immunology, vol. 25, no. 9, pp. 1678-1691.
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AbstractWhole-exome sequencing of two unrelated kindreds with systemic autoimmune disease featuring antinuclear antibodies with IgG4 elevation uncovered an identical ultrarare heterozygous TNIP1Q333P variant segregating with disease. Mice with the orthologous Q346P variant developed antinuclear autoantibodies, salivary gland inflammation, elevated IgG2c, spontaneous germinal centers and expansion of age-associated B cells, plasma cells and follicular and extrafollicular helper T cells. B cell phenotypes were cell-autonomous and rescued by ablation of Toll-like receptor 7 (TLR7) or MyD88. The variant increased interferon-β without altering nuclear factor kappa-light-chain-enhancer of activated B cells signaling, and impaired MyD88 and IRAK1 recruitment to autophagosomes. Additionally, the Q333P variant impaired TNIP1 localization to damaged mitochondria and mitophagosome formation. Damaged mitochondria were abundant in the salivary epithelial cells of Tnip1Q346P mice. These findings suggest that TNIP1-mediated autoimmunity may be a consequence of increased TLR7 signaling due to impaired recruitment of downstream signaling molecules and damaged mitochondria to autophagosomes and may thus respond to TLR7-targeted therapeutics.
Mediati, DG, Blair, TA, Costas, A, Monahan, LG, Söderström, B, Charles, IG & Duggin, IG 2024, 'Genetic requirements for uropathogenic E. coli proliferation in the bladder cell infection cycle', mSystems, vol. 9, no. 10.
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ABSTRACT Uropathogenic Escherichia coli (UPEC) requires an adaptable physiology to survive the wide range of environments experienced in the host, including gut and urinary tract surfaces. To identify UPEC genes required during intracellular infection, we developed a transposon-directed insertion-site sequencing approach for cellular infection models and searched for genes in a library of ~20,000 UTI89 transposon-insertion mutants that are specifically required at the distinct stages of infection of cultured bladder epithelial cells. Some of the bacterial functional requirements apparent in host bladder cell growth overlapped with those for M9-glycerol, notably nutrient utilization, polysaccharide and macromolecule precursor biosynthesis, and cell envelope stress tolerance. Two genes implicated in the intracellular bladder cell infection stage were confirmed through independent gene deletion studies: neuC (sialic acid capsule biosynthesis) and hisF (histidine biosynthesis). Distinct sets of UPEC genes were also implicated in bacterial dispersal, where UPEC erupts from bladder cells in highly filamentous or motile forms upon exposure to human urine, and during recovery from infection in a rich medium. We confirm that the dedD gene linked to septal peptidoglycan remodeling is required during UPEC dispersal from human bladder cells and may help stabilize cell division or the cell wall during envelope stress created by host cells. Our findings support a view that the host intracellular environment and infection cycle are multi-nutrient limited and create stress that demands an array of biosynthetic, cell envelope integrity, and biofilm-...
Mediati, DG, Dan, W, Lalaouna, D, Dinh, H, Pokhrel, A, Rowell, KN, Michie, KA, Stinear, TP, Cain, AK & Tree, JJ 2024, 'The 3′ UTR of vigR is required for virulence in Staphylococcus aureus and has expanded through STAR sequence repeat insertions', Cell Reports, vol. 43, no. 4, pp. 114082-114082.
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Mehta, M, Bui, TA, Care, A & Deng, W 2024, 'Targeted polymer lipid hybrid nanoparticles for in-vitro siRNA therapy in triple-negative breast cancer', Journal of Drug Delivery Science and Technology, vol. 98, pp. 105911-105911.
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Mello, MG, Westerhausen, MT, Lockwood, TE, Singh, P, Wanagat, J & Bishop, DP 2024, 'Immunolabelling perturbs the endogenous and antibody-conjugated elemental concentrations during immuno-mass spectrometry imaging', Analytical and Bioanalytical Chemistry, vol. 416, no. 11, pp. 2725-2735.
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AbstractImmuno-mass spectrometry imaging uses lanthanide-conjugated antibodies to spatially quantify biomolecules via laser ablation-inductively coupled plasma-mass spectrometry (LA-ICP-MS). The multi-element capabilities allow for highly multiplexed analyses that may include both conjugated antibodies and endogenous metals to reveal relationships between disease and chemical composition. Sample handling is known to perturb the composition of the endogenous elements, but there has been little investigation into the effects of immunolabelling and coverslipping. Here, we used cryofixed muscle sections to examine the impact of immunolabelling steps on the concentrations of a Gd-conjugated anti-dystrophin primary antibody, and the endogenous metals Cu and Zn. Primary antibody incubation resulted in a decrease in Zn, and an increase in Cu. Zn was removed from the cytoplasm where it was hypothesised to be more labile, whereas concentrated locations of Zn remained in the cell membrane in all samples that underwent the immunostaining process. Cu increased in concentration and was found mostly in the cell membrane. The concentration of the Gd-conjugated antibody when compared to the standard air-dried sample was not significantly different when coverslipped using an organic mounting medium, whereas use of an aqueous mounting medium significantly reduced the concentration of Gd. These results build on the knowledge of how certain sample handling techniques change elemental concentrations and distributions in tissue sections. Immunolabelling steps impact the concentration of endogenous elements, and separate histological sections are required for the quantitative analysis of endogenous elements and biomolecules. Additionally, coverslipping tissue sections for complementary immunohistochemical/immunofluorescent imaging may compromise the integrity of the elemental label, and organic mounting media are recommended over aqueous mounti...
Merklein, M, Goulden, L, Kiewiet, M, Liu, Y, Lai, CK, Choi, D-Y, Madden, SJ, Poulton, CG & Eggleton, BJ 2024, 'On-chip quasi-light storage for long optical delays using Brillouin scattering', APL Photonics, vol. 9, no. 5.
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Efficient and extended light storage mechanisms are pivotal in photonics, particularly in optical communications, microwave photonics, and quantum networks, as they offer a direct route to circumvent electrical conversion losses and surmount bandwidth constraints. Stimulated Brillouin Scattering (SBS) is an established method to store optical information by transferring it to the acoustic domain, but current on-chip SBS efforts have limited bandwidth or storage time due to the phonon lifetime of several nanoseconds. An alternate approach known as quasi-light storage (QLS), which involves the creation of delayed replicas of optical data pulses via SBS in conjunction with a frequency comb, has been proposed to lift the storage time constraint; however, its realization has been confined to lengthy optical fibers, constraining integration with on-chip optical elements and form factors. Here, we present an experimental demonstration of QLS on a photonic chip leveraging the large SBS gain of chalcogenide glass, achieving delays of up to 500 ns for 1 ns long signal pulses, surpassing typical Brillouin storage processes' acoustic lifetime by more than an order of magnitude and waveguide transit time by two orders of magnitude. We experimentally and numerically investigate the dynamics of on-chip QLS and reveal that the interplay between the acoustic wave that stores the optical signal and subsequent optical pump pulses leads to a reshaping of the acoustic field. Our demonstrations illustrate the potential for achieving ultra-long storage times of individual pulses by several hundred pulse widths, marking a significant stride toward advancing the field of all-optical storage and delay mechanisms.
Mills, J, Gebhard, LJ, Schubotz, F, Shevchenko, A, Speth, DR, Liao, Y, Duggin, IG, Marchfelder, A & Erdmann, S 2024, 'Extracellular vesicle formation in Euryarchaeota is driven by a small GTPase', Proceedings of the National Academy of Sciences, vol. 121, no. 10.
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Since their discovery, extracellular vesicles (EVs) have changed our view on how organisms interact with their extracellular world. EVs are able to traffic a diverse array of molecules across different species and even domains, facilitating numerous functions. In this study, we investigate EV production in Euryarchaeota, using the model organism Haloferax volcanii . We uncover that EVs enclose RNA, with specific transcripts preferentially enriched, including those with regulatory potential, and conclude that EVs can act as an RNA communication system between haloarchaea. We demonstrate the key role of an EV-associated small GTPase for EV formation in H. volcanii that is also present across other diverse evolutionary branches of Archaea. We propose the name, ArvA, for the identified family of archaeal vesiculating GTPases. Additionally, we show that two genes in the same operon with arvA ( arvB and arvC ) are also involved in EV formation. Both, arvB and arvC , are closely associated with arvA in the majority of other archaea encoding ArvA. Our work demonstrates that small GTPases involved in membrane deformation and vesiculation, ubiquitous in Eukaryotes, are also present in Archaea and are widely distributed across diverse archaeal phyla.
Missen, OP, Mills, SJ, Thaise Moro, T, Villalobos-Portillo, EE, Castillo-Michel, H, Lockwood, TE, Gonzalez de Vega, R & Clases, D 2024, 'Natural cobalt–manganese oxide nanoparticles: speciation, detection and implications for cobalt cycling', Environmental Chemistry, vol. 21, no. 2.
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Mitchell, A, Hayes, C, Booth, DJ & Nagelkerken, I 2024, 'Correction to: Projected ocean acidification and seasonal temperature alter the behaviour and growth of a range extending tropical fish', Coral Reefs, vol. 43, no. 1, pp. 67-67.
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Moreno-Gonzalez, M, Hampton, K, Ruiz, P, Beasy, G, Nagies, FSP, Parker, A, Lazenby, J, Bone, C, Alava-Arteaga, A, Patel, M, Hellmich, C, Luri-Martin, P, Silan, E, Philo, M, Baker, D, Rushbrook, SM, Hildebrand, F, Rushworth, SA & Beraza, N 2024, 'Regulation of intestinal senescence during cholestatic liver disease modulates barrier function and liver disease progression', JHEP Reports, vol. 6, no. 10, pp. 101159-101159.
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Morris, MJ, Hasebe, K, Shinde, AL, Leong, MKH, Billah, MM, Hesam-Shariati, S & Kendig, MD 2024, 'Time-restricted feeding does not prevent adverse effects of palatable cafeteria diet on adiposity, cognition and gut microbiota in rats', The Journal of Nutritional Biochemistry, vol. 134, pp. 109761-109761.
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Morshed, N, Rennie, C, Deng, W, Collins-Praino, L & Care, A 2024, 'Serum-derived protein coronas affect nanoparticle interactions with brain cells', Nanotechnology, vol. 35, no. 49, pp. 495101-495101.
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Abstract Neuronanomedicine is an emerging field bridging the gap between neuromedicine and novel nanotherapeutics. Despite promise, clinical translation of neuronanomedicine remains elusive, possibly due to a dearth of information regarding the effect of the protein corona on these neuronanomedicines. The protein corona, a layer of proteins adsorbed to nanoparticles following exposure to biological fluids, ultimately determines the fate of nanoparticles in biological systems, dictating nanoparticle–cell interactions. To date, few studies have investigated the effect of the protein corona on interactions with brain-derived cells, an important consideration for the development of neuronanomedicines. Here, two polymeric nanoparticles, poly(lactic-co-glycolic acid) (PLGA) and PLGA-polyethylene glycol (PLGA-PEG), were used to obtain serum-derived protein coronas. Protein corona characterization and liquid chromatography mass spectrometry analysis revealed distinct differences in biophysical properties and protein composition. PLGA protein coronas contained high abundance of globins (60%) and apolipoproteins (21%), while PLGA-PEG protein coronas contained fewer globins (42%) and high abundance of protease inhibitors (28%). Corona coated PLGA nanoparticles were readily internalized into microglia and neuronal cells, but not into astrocytes. Internalization of nanoparticles was associated with pro-inflammatory cytokine release and decreased neuronal cell viability, however, viability was rescued in cells treated with corona coated nanoparticles. These results showcase the importance of the protein corona in mediating nanoparticle–cell interactions.
Morshedi Rad, D, Hansen, WP, Zhand, S, Cranfield, C & Ebrahimi Warkiani, M 2024, 'A hybridized mechano-electroporation technique for efficient immune cell engineering', Journal of Advanced Research, vol. 64, pp. 31-43.
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Mullens, BG, Marlton, FP, Nicholas, MK, Permana, AJ, Avdeev, M, Mukherjee, S, Vaitheeswaran, G, Li, C, Liu, J, Chater, PA & Kennedy, BJ 2024, 'Seeing the Unseen: The Structural Influence of the Lone Pair Electrons in PbWO4', Inorganic Chemistry, vol. 63, no. 24, pp. 11176-11186.
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Mullens, BG, Marlton, FP, Nicholas, MK, Permana, AJ, Brand, HEA, Maynard‐Casely, HE, Chater, PA & Kennedy, BJ 2024, 'Intercalated Water Drives Anomalous Thermal Expansion in the Tetragonal Zircon Structured Bismuth Vanadate BiVO4 Photocatalyst', Chemistry – An Asian Journal, vol. 19, no. 14.
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AbstractThe thermal transformation of the tetragonal‐zircon (tz‐) to tetragonal‐scheelite (ts‐)BiVO4 was studied by in situ synchrotron X‐ray diffraction, thermogravimetric analysis, and Fourier‐transformed infrared spectroscopy. Upon heating, the tetragonal zircon polymorph of BiVO4 (tz‐BiVO4) transitioned to the ts‐polymorph between 693–773 K. Above 773 K, single phase ts‐BiVO4 was observed before transitioning to the monoclinic fergusonite (mf‐) polymorph upon cooling. An anomaly in thermal expansion was observed between 400–500 K, associated with the loss of intercalated H2O/NH4+ from the coprecipitation procedure. Heating tz‐BiVO4 resulted in contraction of the V−O bond distance and VO4 polyhedra volume, ascribed to rotation of the tetrahedra groups. Attempts to study this by neutron diffraction failed due to the large incoherent scatter from the hydrogenous species. Efforts to remove these species while maintaining the tz‐BiVO4 structure were unsuccessful, suggesting they play a role in stabilizing the tz‐polymorph. The local structure of both mf‐BiVO4 and tz‐BiVO4 were investigated by X‐ray pair distribution function analysis, revealing local distortions.
Mullens, BG, Marlton, FP, Saura-Múzquiz, M, Chater, PA & Kennedy, BJ 2024, 'Tetrahedra Rotational and Displacive Disorder in the Scheelite-Type Oxide CsReO4', Inorganic Chemistry, vol. 63, no. 22, pp. 10386-10396.
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Mullens, BG, Saura-Múzquiz, M, Cordaro, G, Marlton, FP, Maynard-Casely, HE, Zhang, Z, Baldinozzi, G & Kennedy, BJ 2024, 'Variable Temperature In Situ Neutron Powder Diffraction and Conductivity Studies of Undoped HoNbO4 and HoTaO4', Chemistry of Materials, vol. 36, no. 10, pp. 5002-5016.
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Naeem, U, Zahra, SA, Ali, I, Li, H, Mahmood, A & Rizwan, S 2024, 'Unleashing the potential of NiO@V2CTx MXene-derived electrocatalyst for hydrogen and oxygen evolution', International Journal of Hydrogen Energy, vol. 59, pp. 635-644.
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Naghavi, M, Ong, KL, Aali, A, Ababneh, HS, Abate, YH, Abbafati, C, Abbasgholizadeh, R, Abbasian, M, Abbasi-Kangevari, M, Abbastabar, H, Abd ElHafeez, S, Abdelmasseh, M, Abd-Elsalam, S, Abdelwahab, A, Abdollahi, M, Abdollahifar, M-A, Abdoun, M, Abdulah, DM, Abdullahi, A, Abebe, M, Abebe, SS, Abedi, A, Abegaz, KH, Abhilash, ES, Abidi, H, Abiodun, O, Aboagye, RG, Abolhassani, H, Abolmaali, M, Abouzid, M, Aboye, GB, Abreu, LG, Abrha, WA, Abtahi, D, Abu Rumeileh, S, Abualruz, H, Abubakar, B, Abu-Gharbieh, E, Abu-Rmeileh, NME, Aburuz, S, Abu-Zaid, A, Accrombessi, MMK, Adal, TG, Adamu, AA, Addo, IY, Addolorato, G, Adebiyi, AO, Adekanmbi, V, Adepoju, AV, Adetunji, CO, Adetunji, JB, Adeyeoluwa, TE, Adeyinka, DA, Adeyomoye, OI, Admass, BAA, Adnani, QES, Adra, S, Afolabi, AA, Afzal, MS, Afzal, S, Agampodi, SB, Agasthi, P, Aggarwal, M, Aghamiri, S, Agide, FD, Agodi, A, Agrawal, A, Agyemang-Duah, W, Ahinkorah, BO, Ahmad, A, Ahmad, D, Ahmad, F, Ahmad, MM, Ahmad, S, Ahmad, S, Ahmad, T, Ahmadi, K, Ahmadzade, AM, Ahmed, A, Ahmed, A, Ahmed, H, Ahmed, LA, Ahmed, MS, Ahmed, MS, Ahmed, MB, Ahmed, SA, Ajami, M, Aji, B, Akara, EM, Akbarialiabad, H, Akinosoglou, K, Akinyemiju, T, Akkaif, MA, Akyirem, S, Al Hamad, H, Al Hasan, SM, Alahdab, F, Alalalmeh, SO, Alalwan, TA, Al-Aly, Z, Alam, K, Alam, M, Alam, N, Al-amer, RM, Alanezi, FM, Alanzi, TM, Al-Azzam, S, Albakri, A, Albashtawy, M, AlBataineh, MT, Alcalde-Rabanal, JE, Aldawsari, KA, Aldhaleei, WA, Aldridge, RW, Alema, HB, Alemayohu, MA, Alemi, S, Alemu, YM, Al-Gheethi, AAS, Alhabib, KF, Alhalaiqa, FAN, Al-Hanawi, MK, Ali, A, Ali, A, Ali, L, Ali, MU, Ali, R, Ali, S, Ali, SSS, Alicandro, G, Alif, SM, Alikhani, R, Alimohamadi, Y, Aliyi, AA, Aljasir, MAM, Aljunid, SM, Alla, F, Allebeck, P, Al-Marwani, S, Al-Maweri, SAA, Almazan, JU, Al-Mekhlafi, HM, Almidani, L, Almidani, O, Alomari, MA, Al-Omari, B, Alonso, J, Alqahtani, JS, Alqalyoobi, S, Alqutaibi, AY, Al-Sabah, SK, Altaany, Z, Altaf, A, Al-Tawfiq, JA, Altirkawi, KA, Aluh, DO, Alvis-Guzman, N, Alwafi, H, Al-Worafi, YM, Aly, H, Aly, S, Alzoubi, KH, Amani, R, Amare, AT, Amegbor, PM, Ameyaw, EK, Amin, TT, Amindarolzarbi, A, Amiri, S, Amirzade-Iranaq, MH, Amu, H, Amugsi, DA, Amusa, GA, Ancuceanu, R, Anderlini, D, Anderson, DB, Andrade, PP, Andrei, CL, Andrei, T, Angus, C, Anil, A, Anil, S, Anoushiravani, A, Ansari, H, Ansariadi, A & et al. 2024, 'Global burden of 288 causes of death and life expectancy decomposition in 204 countries and territories and 811 subnational locations, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021', The Lancet, vol. 403, no. 10440, pp. 2100-2132.
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Nazarenko, AA, Chernyak, AM, Musorin, AI, Shorokhov, AS, Ding, L, Valuckas, V, Nonahal, M, Aharonovich, I, Ha, ST, Kuznetsov, AI & Fedyanin, AA 2024, 'Cryogenic nonlinear microscopy of high-Q metasurfaces coupled with transition metal dichalcogenide monolayers', Nanophotonics, vol. 13, no. 18, pp. 3429-3436.
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Abstract Monolayers of transition metal dichalcogenides (TMDCs) demonstrate plenty of unique properties due to the band structure. Symmetry breaking brings second-order susceptibility to meaningful values resulting in the enhancement of corresponding nonlinear effects. Cooling the TMDC films to cryogenic temperatures leads to the emergence of two distinct photoluminescence peaks caused by the exciton and trion formation. These intrinsic excitations are known to enhance second harmonic generation. The nonlinear signal can be greatly increased if these material resonances are boosted by high-quality factor geometric resonance of all-dielectric metasurfaces. Here, we experimentally observe optical second harmonic generation caused by excitons of 2D semiconductor MoSe2 at room and cryogenic temperatures enhanced by spectrally overlapped high-Q resonance of TiO2 nanodisks metasurface. The enhancement reaches two orders of magnitude compared to the case when the resonances are not spectrally overlapped.
Nedić, S, Yamamura, K, Gale, A, Aharonovich, I & Toth, M 2024, 'Electron Beam Restructuring of Quantum Emitters in Hexagonal Boron Nitride', Advanced Optical Materials, vol. 12, no. 24.
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AbstractHexagonal boron nitride (hBN) holds promise as a solid state, van der Waals host of single photon emitters for on‐chip quantum photonics. The B‐center defect emitting at 436 nm is particularly compelling as it can be generated by electron beam irradiation. However, the emitter generation mechanism is unknown, the robustness of the method is variable, and it has only been applied successfully to thick flakes of hBN (≫ 10 nm). Here, it is used in situ time‐resolved cathodoluminescence (CL) spectroscopy to investigate the kinetics of B‐center generation. It is shown that the generation of B‐centers is accompanied by quenching of a carbon‐related emission at ≈305 nm and that both processes are rate‐limited by electromigration of defects in the hBN lattice. It identifies problems that limit the efficacy and reproducibility of the emitter generation method and solve them using a combination of optimized electron beam parameters and hBN pre‐and postprocessing treatments. It is achieved B‐center quantum emitters in hBN flakes as thin as 8 nm, elucidate the mechanisms responsible for electron beam restructuring of quantum emitters in hBN, and gain insights toward the identification of the atomic structure of the B‐center quantum emitter.
Neuper, C, Šimić, M, Lockwood, TE, Gonzalez de Vega, R, Hohenester, U, Fitzek, H, Schlatt, L, Hill, C & Clases, D 2024, 'Optofluidic Force Induction Meets Raman Spectroscopy and Inductively Coupled Plasma-Mass Spectrometry: A New Hyphenated Technique for Comprehensive and Complementary Characterizations of Single Particles', Analytical Chemistry, vol. 96, no. 21, pp. 8291-8299.
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Neuteboom, W, Ross, A, Bugeja, L, Willis, S, Roux, C & Lothridge, K 2024, 'Quality management and competencies in forensic science', WIREs Forensic Science, vol. 6, no. 3.
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AbstractThe competencies and attributes of forensic science professionals are a very important pillar of a Quality Management system. However, a recent international survey identified a lack of agreement on the core cognitive competencies required for working in forensic science. The survey also identified the tools for assessing competencies are not necessarily designed to measure cognitive competencies. In this Perspective, we explore further the topic of competencies and in particular, cognitive competencies and attributes with a focus on forensic science professionals. We identify the critical issue and outline a process through which we will seek the views of leaders in the field, both operational and academic, on what the required cognitive competencies and attributes are for forensic science professionals. The tools used will include a questionnaire and direct interviews. Having identified the key competencies and attributes they can then be promoted, and methods developed to assess them within the recruitment process and continuous professional development programs. We argue that further discussion on this topic is warranted as it impacts on forensic science education, training, recruitment, operations, and overall quality.This article is categorized under:Forensic Chemistry and Trace Evidence > Presentation and Evaluation of Forensic Science Output
Neuteboom, W, Ross, A, Bugeja, L, Willis, S, Roux, C & Lothridge, K 2024, 'Quality Management in forensic science: A closer inspection', Forensic Science International, vol. 358, pp. 111779-111779.
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Nguyen, HM, Hong, UVT, Ruocco, M, Dattolo, E, Marín-Guirao, L, Pernice, M & Procaccini, G 2024, 'Thermo-priming triggers species-specific physiological and transcriptome responses in Mediterranean seagrasses', Plant Physiology and Biochemistry, vol. 210, pp. 108614-108614.
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Noh, NJ, Renchon, AA, Knauer, J, Haverd, V, Li, J, Griebel, A, Barton, CVM, Yang, J, Sihi, D, Arndt, SK, Davidson, EA, Tjoelker, MG & Pendall, E 2024, 'Reconciling Top‐Down and Bottom‐Up Estimates of Ecosystem Respiration in a Mature Eucalypt Forest', Journal of Geophysical Research: Biogeosciences, vol. 129, no. 10.
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AbstractEcosystem respiration (Reco) arises from interacting autotrophic and heterotrophic processes constrained by distinct drivers. Here, we evaluated up‐scaling of observed components of Reco in a mature eucalypt forest in southeast Australia and assessed whether a land surface model adequately represented all the fluxes and their seasonal temperature responses. We measured respiration from soil (Rsoil), heterotrophic soil microbes (Rh), roots (Rroot), and stems (Rstem) in 2018–2019. Reco and its components were simulated using the CABLE–POP (Community Atmosphere‐Biosphere Land Exchange–Population Orders Physiology) land surface model, constrained by eddy covariance and chamber measurements and enabled with a newly implemented Dual Arrhenius and Michaelis‐Menten (DAMM) module for soil organic matter decomposition. Eddy‐covariance based Reco (Reco.eddy, 1,439 g C m−2 y−1) was slightly higher than the sum of the respiration components (Reco.sum, 1,295 g C m−2 y−1) and simulated Reco (1,297 g C m−2 y−1). The largest mean contribution to Reco was from Rsoil (64%) across seasons. The measured contributions of Rh (49%), Rroot (15%), and Rstem (22%) to Reco.sum were very close to model outputs of 46%, 11%, and 22%, respectively. The modeled Rh was highly correlated with measured Rh (R2 = 0.66, RMSE = 0.61), empirically validating the DAMM module. The apparent temperature sensitivities (Q
O’Donnell, AW, Redmond, G, Gardner, AA, Wang, JJJ & Mooney, A 2024, 'Extracurricular activity participation, school belonging, and depressed mood: a test of the compensation hypothesis during adolescence', Applied Developmental Science, vol. 28, no. 4, pp. 596-611.
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Okashiro, Y, Takashima, H, Shimazaki, K, Suzuki, K, Mukai, Y, Aharonovich, I & Takeuchi, S 2024, 'Selective Anti-Stokes Excitation of a Single Defect Center in Hexagonal Boron Nitride', ACS Photonics, vol. 11, no. 9, pp. 3602-3609.
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Okoh, EB, Payne, M, Lan, R, Riegler, M, Chapman, TA & Bogema, DR 2024, 'A Multilocus Sequence Typing Scheme for Rapid Identification of Xanthomonas citri Based on Whole-Genome Sequencing Data', Phytopathology®, vol. 114, no. 7, pp. 1480-1489.
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Xanthomonas citri is a plant-pathogenic bacterium associated with a diverse range of host plant species. It has undergone substantial reclassification and currently consists of 14 different subspecies or pathovars that are responsible for a wide range of plant diseases. Whole-genome sequencing (WGS) provides a cutting-edge advantage over other diagnostic techniques in epidemiological and evolutionary studies of X. citri because it has a higher discriminatory power and is replicable across laboratories. WGS also allows for the improvement of multilocus sequence typing (MLST) schemes. In this study, we used genome sequences of Xanthomonas isolates from the NCBI RefSeq database to develop a seven-gene MLST scheme that yielded 19 sequence types (STs) that correlated with phylogenetic clades of X. citri subspecies or pathovars. Using this MLST scheme, we examined 2,911 Xanthomonas species assemblies from NCBI GenBank and identified 15 novel STs from 37 isolates that were misclassified in NCBI. In total, we identified 545 X. citri assemblies from GenBank with 95% average nucleotide identity to the X. citri type strain, and all were classified as one of the 34 STs. All MLST classifications correlated with a phylogenetic position inferred from alignments using 92 conserved genes. We observed several instances where strains from different pathovars formed closely related monophyletic clades and shared the same ST, indicating that further investigation of the validity of these pathovars is required. Our MLST scheme described here is a robust tool for rapid classification of X. citri pathovars using WGS and a powerful method for further comprehensive taxonomic revision of X. citri pathovars.
Oliva, D, Piro, A, Carbone, M, Mollo, E, Kumar, M, Scarcelli, F, Nisticò, DM & Mazzuca, S 2024, 'Physiological and proteomic responses of Posidonia oceanica to phytotoxins of invasive Caulerpa species', Environmental and Experimental Botany, vol. 228, pp. 105987-105987.
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Oliver, BG & Foster, PS 2024, 'To burn or not to burn: similar effects of different types of prenatal tobacco exposure on infant lung function', ERJ Open Research, vol. 10, no. 4, pp. 00294-2024.
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Oliver, BG, Huang, X, Yarak, R, Bai, X, Wang, Q, Zakarya, R, Reddy, KD, Donovan, C, Kim, RY, Morkaya, J, Wang, B, Lung Chan, Y, Saad, S, Faiz, A, Reyk, DV, Verkhratsky, A, Yi, C & Chen, H 2024, 'Chronic maternal exposure to low-dose PM2.5 impacts cognitive outcomes in a sex-dependent manner', Environment International, vol. 191, pp. 108971-108971.
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Pan, H, Huang, Y, Cen, X, Zhang, M, Hou, J, Wu, C, Dou, Y, Sun, B, Wang, Y, Zhang, B & Zhang, L 2024, 'Hollow Carbon and MXene Dual‐Reinforced MoS2 with Enlarged Interlayers for High‐Rate and High‐Capacity Sodium Storage Systems', Advanced Science, vol. 11, no. 37.
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AbstractSodium‐ion batteries (SIBs) and sodium‐ion capacitors (SICs) are promising candidates for cost‐effective and large‐scale energy storage devices. However, sluggish kinetics and low capacity of traditional anode materials inhibit their practical applications. Herein, a novel design featuring a layer‐expanded MoS2 is presented that dual‐reinforced by hollow N, P‐codoped carbon as the inner supporter and surface groups abundant MXene as the outer supporter, resulting in a cross‐linked robust composite (NPC@MoS2/MXene). The hollow N, P‐codoped carbon effectively prevents agglomeration of MoS2 layers and facilitates shorter distances between the electrolyte and electrode. The conductive MXene outer surface envelops the NPC@MoS2 units inside, creating interconnected channels that enable efficient charge transfer and diffusion, ensuring rapid kinetics and enhanced electrode utilization. It exhibits a high reversible capacity of 453 mAh g−1, remarkable cycling stability, and exceptional rate capability with 54% capacity retention when the current density increases from 100 to 5000 mA g−1 toward SIBs. The kinetic mechanism studies reveal that the NPC@MoS2/MXene demonstrates a pseudocapacitance dominated hybrid sodiation/desodiation process. Coupled with active carbon (AC), the NPC@MoS2/MXene//AC SICs achieve both high energy density of 136 Wh kg−1 at 254 W kg−1 and high‐power density of 5940 W kg−1 at 27 Wh g−1, maintaining excellent stability.
Pandey, A, Shen, C, Feng, S, Enosi Tuipulotu, D, Ngo, C, Liu, C, Kurera, M, Mathur, A, Venkataraman, S, Zhang, J, Talaulikar, D, Song, R, Wong, JJ-L, Teoh, N, Kaakoush, NO & Man, SM 2024, 'Ku70 senses cytosolic DNA and assembles a tumor-suppressive signalosome', Science Advances, vol. 10, no. 4.
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The innate immune response contributes to the development or attenuation of acute and chronic diseases, including cancer. Microbial DNA and mislocalized DNA from damaged host cells can activate different host responses that shape disease outcomes. Here, we show that mice and humans lacking a single allele of the DNA repair protein Ku70 had increased susceptibility to the development of intestinal cancer. Mechanistically, Ku70 translocates from the nucleus into the cytoplasm where it binds to cytosolic DNA and interacts with the GTPase Ras and the kinase Raf, forming a tripartite protein complex and docking at Rab5 + Rab7 + early-late endosomes. This Ku70-Ras-Raf signalosome activates the MEK-ERK pathways, leading to impaired activation of cell cycle proteins Cdc25A and CDK1, reducing cell proliferation and tumorigenesis. We also identified the domains of Ku70, Ras, and Raf involved in activating the Ku70 signaling pathway. Therapeutics targeting components of the Ku70 signalosome could improve the treatment outcomes in cancer.
Pang, L, Lu, J, Yu, Y, Li, D, Chen, Y, Wang, S, Wang, Y, Sun, B, Wang, H & Wang, G 2024, 'Cationic Metal–Organic Framework Arrays to Enable Dendrite-Free Lithium Metal Anodes', ACS Energy Letters, vol. 9, no. 8, pp. 3746-3753.
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Panthi, VK, Bashyal, S & Paudel, KR 2024, 'Docetaxel-loaded nanoformulations delivery for breast cancer management: Challenges, recent advances, and future perspectives', Journal of Drug Delivery Science and Technology, vol. 92, pp. 105314-105314.
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Parker, LM, Scanes, E, O'Connor, WA, Dove, M, Elizur, A, Pörtner, H-O & Ross, PM 2024, 'Resilience against the impacts of climate change in an ecologically and economically significant native oyster', Marine Pollution Bulletin, vol. 198, pp. 115788-115788.
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Passarelli, N, Palomba, S, Kabakova, I & de Sterke, CM 2024, 'Rational design of an integrated directional coupler for wideband operation', Applied Optics, vol. 63, no. 14, pp. D28-D28.
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We consider a design procedure for directional couplers for which the coupling length is approximately wavelength-independent over a wide bandwidth. We show analytically that two coupled planar waveguides exhibit a maximum in the coupling strength, which ensures both wideband transmission and minimal device footprint. This acts as a starting point for mapping out the relevant part of phase space. This analysis is then generalized to the fully three-dimensional geometry of rib waveguides using an effective medium approximation. This forms an excellent starting point for fully numerical calculations and leads to designs with unprecedented bandwidths and compactness.
Patel, MN, Patel, AJ, Nandpal, MN, Raval, MA, Patel, RJ, Patel, AA, Paudel, KR, Hansbro, PM, Singh, SK, Gupta, G, Dua, K & Patel, SG 2024, 'Advancing against drug-resistant tuberculosis: an extensive review, novel strategies and patent landscape', Naunyn-Schmiedeberg's Archives of Pharmacology.
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Drug-resistant tuberculosis (DR-TB) represents a pressing global health issue, leading to heightened morbidity and mortality. Despite extensive research efforts, the escalation of DR-TB cases underscores the urgent need for enhanced prevention, diagnosis, and treatment strategies. This review delves deep into the molecular and genetic origins of different types of DR-TB, highlighting recent breakthroughs in detection and diagnosis, including Rapid Diagnostic Tests like Xpert Ultra, Whole Genome Sequencing, and AI-based tools along with latest viewpoints on diagnosis and treatment of DR-TB utilizing newer and repurposed drug molecules. Special emphasis is given to the pivotal role of novel drugs and discusses updated treatment regimens endorsed by governing bodies, alongside innovative personalized drug-delivery systems such as nano-carriers, along with an analysis of relevant patents in this area. All the compiled information highlights the inherent challenges of current DR-TB treatments, discussing their complexity, potential side effects, and the socioeconomic strain they impose, particularly in under-resourced regions, emphasizing the cost-effective and accessible solutions. By offering insights, this review aims to serve as a compass for researchers, healthcare practitioners, and policymakers, emphasizing the critical need for ongoing R&D to improve treatments and broaden access to crucial TB interventions.
Paudel, KR, Clarence, DD, Panth, N, Manandhar, B, De Rubis, G, Devkota, HP, Gupta, G, Zacconi, FC, Williams, KA, Pont, LG, Singh, SK, Warkiani, ME, Adams, J, MacLoughlin, R, Oliver, BG, Chellappan, DK, Hansbro, PM & Dua, K 2024, 'Zerumbone liquid crystalline nanoparticles protect against oxidative stress, inflammation and senescence induced by cigarette smoke extract in vitro', Naunyn-Schmiedeberg's Archives of Pharmacology, vol. 397, no. 4, pp. 2465-2483.
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AbstractThe purpose of this study was to evaluate the potential of zerumbone-loaded liquid crystalline nanoparticles (ZER-LCNs) in the protection of broncho-epithelial cells and alveolar macrophages against oxidative stress, inflammation and senescence induced by cigarette smoke extract in vitro. The effect of the treatment of ZER-LCNs on in vitro cell models of cigarette smoke extract (CSE)-treated mouse RAW264.7 and human BCi-NS1.1 basal epithelial cell lines was evaluated for their anti-inflammatory, antioxidant and anti-senescence activities using colorimetric and fluorescence-based assays, fluorescence imaging, RT-qPCR and proteome profiler kit. The ZER-LCNs successfully reduced the expression of pro-inflammatory markers including Il-6, Il-1β and Tnf-α, as well as the production of nitric oxide in RAW 264.7 cells. Additionally, ZER-LCNs successfully inhibited oxidative stress through reduction of reactive oxygen species (ROS) levels and regulation of genes, namely GPX2 and GCLC in BCi-NS1.1 cells. Anti-senescence activity of ZER-LCNs was also observed in BCi-NS1.1 cells, with significant reductions in the expression of SIRT1, CDKN1A and CDKN2A. This study demonstrates strong in vitro anti-inflammatory, antioxidative and anti-senescence activities of ZER-LCNs paving the path for this formulation to be translated into a promising therapeutic agent for chronic respiratory inflammatory conditions including COPD and asthma.
Paudel, KR, Mohamad, MSB, De Rubis, G, Reyes, R-J, Panth, N, Dureja, H, Gupta, G, Singh, SK, Madheswaran, T, Collet, T, Hansbro, PM, Dua, K & Chellappan, DK 2024, '18-β-Glycyrrhetinic acid encapsulated PLGA nanoparticles attenuate lung cancer proliferation and migration', Journal of Drug Delivery Science and Technology, vol. 95, pp. 105523-105523.
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Paudel, KR, Singh, M, De Rubis, G, Kumbhar, P, Mehndiratta, S, Kokkinis, S, El-Sherkawi, T, Gupta, G, Singh, SK, Malik, MZ, Mohammed, Y, Oliver, BG, Disouza, J, Patravale, V, Hansbro, PM & Dua, K 2024, 'Computational and biological approaches in repurposing ribavirin for lung cancer treatment: Unveiling antitumorigenic strategies', Life Sciences, vol. 352, pp. 122859-122859.
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Paudel, L, Neupane, R, Shrestha, L, Budhathoki, L & Paudel, KR 2024, 'Knowledge on Chemical Pesticide use among Farmers Exposed to Pesticides in Panchkhal Municipality, Kavrepalanchok, Nepal', Advances in Public Health, vol. 2024, no. 1.
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Background. Pesticide exposure is a serious threat to public health in developing countries like Nepal. As an agricultural country, farmers are using pesticides indiscriminately to increase the yield of crops, which results in continued contamination of the environment and food and has adverse effects on human health. This study aims to assess the knowledge and evaluate the relationship between pesticide use knowledge and pesticide toxicity symptoms among farmers in Panchkhal Municipality. Materials and Methods. A cross‐sectional study design was used among 238 farmers (both male and female) exposed to pesticides for a minimum of 1 year. The data collection period was from April to June 2022. The data were collected using convenient sampling through interviews. Semistructured questionnaires were used as a tool for data collection. This study has been approved by the ethics committee. Data entry and analysis were done in SPSS version 16.00. Bivariate analysis was done using the Chi‐square test. Results. The mean age ± SD of the participants was 45.75 ± 13.12 years. The mean year of exposure was 15.52 ± 9.46 years, and the mean duration of working in the field was 3.22 ± 2.17 hr/day. Burning eye (51.2%) was the most common symptom of pesticide poisoning. The most common pesticide used was insecticide. Most farmers (92.4%) had good knowledge of the use of pesticides. There was no significant association between the symptoms of pesticide exposure and knowledge. Those who stored the pesticide properly in a locked container in a well‐ventilated area showed a significant association with knowledge of pesticide use (P ≤ 0.001). Conclusion. This study showed that most farmers have good knowledge of pesticide use. Still, educational programs and legislation promoting the use of safer pesticides are needed because they are ...
Perveen, S, Padula, MP, Safdar, N & Abbas, S 2024, 'Functional annotation of proteins in Catharanthus roseus shoot cultures under biogenic zinc nanotreatment', Plant Molecular Biology, vol. 114, no. 2.
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Peters, SJ, Mitrovic, SM, Rodgers, KJ & Bishop, DP 2024, 'Bioaccumulation of β-methylamino-L-alanine (BMAA) by mussels exposed to the cyanobacteria Microcystis aeruginosa', Environmental Pollution, vol. 363, pp. 125081-125081.
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Pham, NHT, Joglekar, MV, Wong, WKM, Nassif, NT, Simpson, AM & Hardikar, AA 2024, 'Short-chain fatty acids and insulin sensitivity: a systematic review and meta-analysis', Nutrition Reviews, vol. 82, no. 2, pp. 193-209.
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Abstract Context There is substantial evidence that reduced short-chain fatty acids (SCFAs) in the gut are associated with obesity and type 2 diabetes, although findings from clinical interventions that can increase SCFAs are inconsistent. Objective This systematic review and meta-analysis aimed to assess the effect of SCFA interventions on fasting glucose, fasting insulin, and homeostatic model assessment of insulin resistance (HOMA-IR). Data Sources Relevant articles published up to July 28, 2022, were extracted from PubMed and Embase using the MeSH (Medical Subject Headings) terms of the defined keywords [(short-chain fatty acids) AND (obesity OR diabetes OR insulin sensitivity)] and their synonyms. Data analyses were performed independently by two researchers who used the Cochrane meta-analysis checklist and the PRISMA guidelines. Data Extraction Clinical studies and trials that measured SCFAs and reported glucose homeostasis parameters were included in the analysis. Standardized mean differences (SMDs) with 95%CIs were calculated using a random-effects model in the data extraction tool Review Manager version 5.4 (RevMan 5.4). The risk-of-bias assessment was performed following the Cochrane checklist for randomized and crossover studies. Data Analysis In total, 6040 nonduplicate studies were identified, 23 of which me...
Picci, G, Montis, R, Gilchrist, AM, Gale, PA & Caltagirone, C 2024, 'Fluorescent and colorimetric sensors for anions: Highlights from 2020 to 2022', Coordination Chemistry Reviews, vol. 501, pp. 215561-215561.
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Pierce, JE, Cavanaugh, R, Harvey, S, Dickey, MW, Nickels, L, Copland, D, Togher, L, Godecke, E, Meinzer, M, Rai, T, Cadilhac, DA, Kim, J, Hurley, M, Foster, AM, Carragher, M, Wilcox, C & Rose, ML 2024, 'High-Intensity Aphasia Intervention Is Minimally Fatiguing in Chronic Aphasia: An Analysis of Participant Self-Ratings From a Large Randomized Controlled Trial', Stroke, vol. 55, no. 7, pp. 1877-1885.
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BACKGROUND: High-intensity therapy is recommended in current treatment guidelines for chronic poststroke aphasia. Yet, little is known about fatigue levels induced by treatment, which could interfere with rehabilitation outcomes. We analyzed fatigue experienced by people with chronic aphasia (>6 months) during high-dose interventions at 2 intensities. METHODS: A retrospective observational analysis was conducted on self-rated fatigue levels of people with chronic aphasia (N=173) collected during a previously published large randomized controlled trial of 2 treatments: constraint-induced aphasia therapy plus and multi-modality aphasia therapy. Interventions were administered at a higher intensity (30 hours over 2 weeks) or lower intensity (30 hours over 5 weeks). Participants rated their fatigue on an 11-point scale before and after each day of therapy. Data were analyzed using Bayesian ordinal multilevel models. Specifically, we considered changes in self-rated participant fatigue across a therapy day and over the intervention period. RESULTS: Data from 144 participants was analyzed. Participants were English speakers from Australia or New Zealand (mean age, 62 [range, 18–88] years) with 102 men and 42 women. Most had mild (n=115) or moderate (n=52) poststroke aphasia. Median ratings of the level of fatigue by people with aphasia were low (1 on a 0–10-point scale) at the beginning of the day. Ratings increased slightly (+1.0) each day after intervention, with marginally lower increases in the lower intensity schedule. There was no evidence of accumulating fatigue over the 2- or 5-week interventions.
Pierce, JE, OHalloran, R, Togher, L, Nickels, L, Copland, D, Godecke, E, Meinzer, M, Rai, T, Cadilhac, DA, Kim, J, Hurley, M, Foster, A, Carragher, M, Wilcox, C, Steel, G & Rose, ML 2024, 'Acceptability, feasibility and preliminary efficacy of low-moderate intensity Constraint Induced Aphasia Therapy and Multi-Modality Aphasia Therapy in chronic aphasia after stroke', Topics in Stroke Rehabilitation, vol. 31, no. 1, pp. 44-56.
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Pinkeaw, S, Boonrat, P, Koedsin, W & Huete, A 2024, 'Semi-automated mangrove mapping at National-Scale using Sentinel-2, Sentinel-1, and SRTM data with Google Earth Engine: A case study in Thailand', The Egyptian Journal of Remote Sensing and Space Sciences, vol. 27, no. 3, pp. 555-564.
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Qian, C, Zhou, Y, Zhang, T, Dong, G, Song, M, Tang, Y, Wei, Z, Yu, S, Shen, Q, Chen, W, Choi, JP, Yan, J, Zhong, C, Wan, L, Li, J, Wang, A, Lu, Y & Zhao, Y 2024, 'Targeting PKM2 signaling cascade with salvianic acid A normalizes tumor blood vessels to facilitate chemotherapeutic drug delivery', Acta Pharmaceutica Sinica B, vol. 14, no. 5, pp. 2077-2096.
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Qiao, L, Li, M, Cui, Y, Xu, S, Reimers, JR & Ren, W 2024, 'Giant Carrier Mobility in a Room-Temperature Ferromagnetic VSi2N4 Monolayer', Nano Letters, vol. 24, no. 21, pp. 6403-6409.
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Using density functional theory (DFT), we investigate that two possible phases of VSi2N4 (VSN) may be realized, one called the 'H phase' corresponding to what is known from calculation and herein the other new 'T phase' being stabilized by a biaxial tensile strain of 3%. Significantly, the H phase is predicted to display a giant carrier mobility of 1 × 106 cm2 V-1 s-1, which exceeds that for most 2D magnetic materials, with a Curie temperature (TC) exceeding room temperature and a band gap of 2.01 eV at the K point. Following the H-T phase transition, the direct band gap shifts to the Γ point and increases to 2.59 eV. The Monte Carlo (MC) simulations also indicate that TC of the T phase VSN can be effectively modulated by strain, reaching room temperature under a biaxial strain of -4%. These results show that VSN should be a promising functional material for future nanoelectronics.
Quan, X, Chen, R, Yebra, M, Riaño, D, Resco de Dios, V, Li, X, He, B, Nolan, RH, Griebel, A, Boer, MM & Sun, Y 2024, 'Sub-daily live fuel moisture content estimation from Himawari-8 data', Remote Sensing of Environment, vol. 308, pp. 114170-114170.
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Quinteros, SL, Snyder, NW, Chatoff, A, Ryan, F, O'Brien, B & Donnelly, S 2024, 'The helminth‐derived peptide, FhHDM‐1, reverses the trained phenotype of NOD bone‐marrow‐derived macrophages and regulates proinflammatory responses', European Journal of Immunology, vol. 54, no. 6.
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Rahman, MK, Umashankar, B, Choucair, H, Bourget, K, Rawling, T & Murray, M 2024, 'The inositol-requiring enzyme 1 (IRE1) endoplasmic reticulum stress pathway promotes MDA-MB-231 cell survival and renewal in response to the aryl-ureido fatty acid CTU', The International Journal of Biochemistry & Cell Biology, vol. 171, pp. 106571-106571.
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Rajapaksha, RWPM, Attanayaka, DPSTG, Vivehananthan, K & McNevin, D 2024, 'Metagenomic analysis of endophytic bacteria in seed potato (Solanum tuberosum)', Open Life Sciences, vol. 19, no. 1.
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Abstract To date, the association of potato tuber microbiota is poorly understood. In this study, the endophytic bacterial flora of seed potato tubers was identified and the diversity of healthy and unhealthy tubers was compared. Metagenomic DNA extracted from healthy and unhealthy samples of seed potato tubers was used for the analysis of microbial communities. Next generation sequencing of the ∼460 bp v3–v4 region of the 16S rRNA gene was carried out using the Illumina Miseq platform. The data were analysed using the Divisive Amplicon Denoising Algorithm 2 pipeline. Sequence analysis of the potato metagenome identified amplicon sequence variants (ASVs) assigned to 745 different taxa belonging to eight Phyla: Firmicutes (46.2%), Proteobacteria (36.9%), Bacteroidetes (1.8%), Actinobacteria (0.1%), Tenericutes (0.005%), Saccharibacteria (0.003%), Verrucomicrobiota (0.003%), and Acidobacteria (0.001%). In healthy seed potato tubers, 55–99% of ASVs belonged to Firmicutes, including Bacillus, Salinibacillus, Staphylococcus, Lysinibacillus, Paenibacillus, and Brevibacillus genera within the taxonomic order Bacillales. However, in the visually unhealthy tubers, only 0.5–3.9% of ASVs belonged to Firmicutes while 84.1–97% of ASVs belonged to Proteobacteria. This study highlights that diverse bacterial communities colonize potato tubers, which contributes to the understanding of plant–microbe interactions and underscores the significance of metagenomic approaches in agricultural research.
Rao, KK, Dwivedi, SK, Kumar, S, Samal, SK, Singh, NR, Mishra, JS, Prakash, V, Choubey, AK, Kumar, M & Bhatt, BP 2024, 'Impact of simultaneous increase in CO2 and temperature on soil aggregates, associated organic carbon, and nutritional quality of rice–wheat grains', Journal of Plant Nutrition and Soil Science, vol. 187, no. 4, pp. 470-483.
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AbstractBackgroundFood and nutritional security remain a major thrust area in the under developed and developing countries. These problems are exaggerated by the unprecedented challenges of climate change.AimsThe aim of this study was to assess the impact of climate change on grain quality of wheat and rice genotypes as well as their effect on soil aggregate fractions and aggregate associated carbon.MethodologyIn the context, the present study was formulated by considering four predicted climate scenarios, namely, T0C0 (ambient condition), T0C1 (approx. 25% higher CO2), T1C0 (2°C higher temperature) and T1C1 (25% higher CO2 + 2°C higher temperature) and their impact on grain quality of wheat (HD2967, HD2733, DBW17, and HD3093) and rice (IR83376‐B‐B‐24‐2, IR84895‐B‐127‐CRA‐5‐1‐1, R Bhagwati, and IR64) genotypes as well as soil aggregate fractions and aggregate associated carbon.ResultsThe result revealed that T0C1 has a negative impact on grain nitrogen and protein content. On an average, nitrogen content in wheat and rice showed a decrease of about 15.55% (5.52%–25.32%) and 11.44% (3.33%–23.86%), respectively. Interestingly, the concurrent effect of elevated CO2 and temperature resulted in higher nitrogen and protein content as compared to other climate conditions. Further, P (P) content in the wheat and rice grains also improved under the elevated CO2 condition, whereas the content of potassium was not significa...
REDMOND, G, MAIN, G, O’DONNELL, AW, SKATTEBOL, J, WOODMAN, R, MOONEY, A, WANG, J, TURKMANI, S, THOMSON, C & BROOKS, F 2024, 'Who excludes? Young People’s Experience of Social Exclusion', Journal of Social Policy, vol. 53, no. 1, pp. 236-259.
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AbstractExisting policy research has not comprehensively examined the processes by which young people experience social exclusion: that is, the relationships among different risk factors for exclusion, their actual experiences of exclusion, and outcomes that matter for their life chances. Drawing on data from a survey of Australian 13-14 year olds (N=3,535), this paper adapts the Bristol Social Exclusion Matrix to examine pathways from young people’s personal and family resources, their experience of participation (school engagement; bullying victimization; teacher support), and their life satisfaction – a predictive indicator of wellbeing and mental health in adulthood. The effects of other characteristics or risk factors for young people’s social exclusion (living with disability, being a young carer, identifying as Indigenous, and speaking a language other than English at home), are also examined. This paper shows that experience of exclusion mediates the relationship between young people’s personal and family resources and life satisfaction. Controlling for characteristics or risk factors does not change this relationship, suggesting that processes of social exclusion, enacted in interpersonal encounters, are driven by overarching structural factors. These findings are relevant for policy in Australia, and in other countries with similar policy regimes.
Rennie, C, Sives, C, Boyton, I, Diaz, D, Gorrie, C, Vittorio, O, Collins‐Praino, L & Care, A 2024, 'In Vivo Behavior of Systemically Administered Encapsulin Protein Nanocages and Implications for their use in Targeted Drug Delivery', Advanced Therapeutics, vol. 7, no. 2.
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AbstractEncapsulins, self‐assembling protein nanocages derived from prokaryotes, are promising nanoparticle‐based drug delivery systems (NDDS). However, the in vivo behavior and fate of encapsulins are poorly understood. In this study, the interactions between the model encapsulin from Thermotoga maritima (TmEnc) and key biological barriers encountered by NDDS are probed. Here, a purified TmEnc formulation that exhibits colloidal stability, storability, and blood compatibility is intravenously injected into BALB/c mice. TmEnc has an excellent nanosafety profile, with no abnormal weight loss or gross pathology observed, and only temporary alterations in toxicity biomarkers are detected. Notably, TmEnc demonstrates immunogenic properties, inducing the generation of nanocage‐specific IgM and IgG antibodies, but without any prolonged pro‐inflammatory effects. An absence of antibody cross‐reactivity also suggests immune‐orthogonality among encapsulin systems. Moreover, TmEnc forms a serum‐derived protein corona on its surface which changes dynamically and appears to play a role in immune recognition. TmEnc's biodistribution profile further reveals its sequestration from the blood circulation by the liver and then biodegrades within Kupffer cells, thus indicating clearance via the mononuclear phagocyte system. Collectively, these findings provide critical insights into how encapsulins behave in vivo, thereby informing their future design, modification, and application in targeted drug delivery.
Rennie, C, Sives, C, Boyton, I, Diaz, D, Gorrie, C, Vittorio, O, Collins‐Praino, L & Care, A 2024, 'In Vivo Behavior of Systemically Administered Encapsulin Protein Nanocages and Implications for their use in Targeted Drug Delivery (Adv. Therap. 2/2024)', Advanced Therapeutics, vol. 7, no. 2.
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Ridlen, R, Marsters, V, Clarke, E, McGrath, K & Gorrie, CA 2024, 'Development of a chronic compression spinal cord injury model in neonatal and adult rats', Animal Models and Experimental Medicine, vol. 7, no. 5, pp. 758-768.
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AbstractBackgroundSpinal cord injury presents a significant burden globally, with traumatic spinal cord injury being the predominant cause historically. However, nontraumatic spinal cord injury (NTSCI) is emerging as a significant contributor, particularly in developed nations, yet it remains poorly understood due to underreporting and misclassification. NTSCI, spanning various etiologies such as bony growths, vascular conditions, infections, neoplastic conditions, and immune disorders, poses unique challenges in diagnosis and treatment, often resulting in lifelong morbidity. This study addresses the lack of suitable animal models for NTSCI research, especially in neonatal animals.MethodsUtilizing a solid spacer approach, we developed a compression NTSCI model applicable to both neonatal and adult Sprague–Dawley rats.ResultsThrough anatomical measurements and in vivo experiments, we confirmed the feasibility and safety of the spacer insertion procedure and observed no acute off‐target effects.ConclusionThe versatility of this model lies in its adaptability to different ages of rats, offering a cost‐effective and reproducible means to induce graded injuries. Moreover, behavioral assessments demonstrated observable hindlimb function, validating the model's utility for studying functional outcomes. Although challenges persist, particularly in accounting for spinal column growth in neonatal animals, this model fills a crucial gap in pediatric NTSCI research. By providing a platform to investigate pathophysiological mechanisms and test potential treatments, it offers promising avenues for advancing our understanding and management of pediatric NTSCI.
Rigg, AL, Bellotto, C, Fowler, AM & Booth, DJ 2024, 'Staining protocols affect use of otolith to estimate the demography of the damselfish sergeant major (Abudefduf vaigiensis)', Journal of Fish Biology, vol. 104, no. 3, pp. 878-882.
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AbstractThis study assessed the otolith (sagittae, lapilli, and asterisci) increment deposition rate in the range‐shifting damselfish, A. vaigiensis, using different concentrations of Alizain Red S and evaluated the impact of staining on increment width. Daily increment deposition was verified in all otolith types and presented clearer fluorescent markings in the lapilli and sagittae than the asterisci, with high stain concentration showing the best clarity. Higher stain concentrations were found to decrease increment width, suggesting care is needed when using stained otoliths as a proxy for growth for this species.
Ritchie, RJ, Sma-Air, S, Johnson, MS, Murray, SA, Nguyen, A, Larkum, AWD & Dummee, V 2024, 'Photosynthesis in a green alga (zoochlorella), Chlorella cf. vulgaris in the soft coral Sarcophyton sp.', Phycologia, vol. 63, no. 1, pp. 60-73.
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Roper, CD, Matthews, JL, Camp, EF, Padula, MP, Kuzhiumparambil, U, Edmondson, J, Howlett, L & Suggett, DJ 2024, 'Lipid composition of coral propagules and reproductive material in coral restoration nurseries', Coral Reefs, vol. 43, no. 5, pp. 1483-1496.
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AbstractCoral restoration efforts have rapidly increased worldwide, including the development of several programmes on the Great Barrier Reef (GBR) in recent years. While many restoration programmes utilise in-water nurseries to accelerate coral biomass yields, the impact of nursery environments on propagule quality has not been examined despite the importance of coral fitness for ensuring resistant populations. Here, we investigated two fitness indicators (lipid diversity and tissue protein abundance) of Acropora millepora adults and eggs grown on coral nurseries versus native reef on the GBR, with adults assessed at two sites (Blue Lagoon and Rayban) and eggs assessed at one site (Blue Lagoon). Lipid profiles of adult colonies varied by site and origin (nursery versus wild reef), with adult nursery corals exhibiting an elevated relative abundance of storage lipids (diacylglycerols and triacylglycerols) and lipid classes responsible for regulating membrane structure (phosphatidylcholines and sterol esters), while wild corals were characterised by a greater relative abundance of fatty acids and classes involved in immunoregulation. Comparing eggs from different origins, nursery offspring were richer in energy-storing triacylglycerols, as well as ceramides and phosphatidylcholines essential for membrane structure, while wild eggs had a greater relative abundance of wax ester species also important for energy storage. No differences were found in total protein abundance (adult or eggs) or egg physical characteristics (count and size) between nursery and wild origins. Variations in lipid profiles are consistent with differences in environmental conditions between reef sites and origin (nursery versus wild), highlighting the need to consider site selection and propagation conditions when planning restoration projects. Importantly, these findings demonstrate that the lipid classes with the highest r...
Ross, PM, Pine, C, Scanes, E, Byrne, M, O’Connor, WA, Gibbs, M & Parker, LM 2024, 'Meta-analyses reveal climate change impacts on an ecologically and economically significant oyster in Australia', iScience, pp. 110673-110673.
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Roy Chowdhury, P, Alhamami, T, Venter, H, Veltman, T, Carr, M, Mollinger, J, Trott, DJ & Djordjevic, SP 2024, 'Identification and evolution of ICE-PmuST394: a novel integrative conjugative element in Pasteurella multocida ST394', Journal of Antimicrobial Chemotherapy, vol. 79, no. 4, pp. 851-858.
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Abstract Background The emergence of macrolide and tetracycline resistance within Pasteurella multocida isolated from feedlot cattle and the dominance of ST394 in Australia was reported recently. Objectives To establish the genetic context of the resistance genes in P. multocida 17BRD-035, the ST394 reference genome, and conduct a molecular risk assessment of their ability to disperse laterally. Methods A bioinformatic analysis of the P. multocida 17BRD-035 genome was conducted to determine if integrative conjugative elements (ICEs) carrying resistance genes, which hamper antibiotic treatment options locally, are in circulation in Australian feedlots. Results A novel element, ICE-PmuST394, was characterized in P. multocida 17BRD-035. It was also identified in three other isolates (two ST394s and a ST125) in Australia and is likely present in a genome representing P. multocida ST79 from the USA. ICE-PmuST394 houses a resistance module carrying two variants of the blaROB gene, blaROB-1 and blaROB-13, and the macrolide esterase gene, estT. The resistance gene combination on ICE-PmuST394 confers resistance to ampicillin and tilmicosin, but not to tulathromycin and tildipirosin. Our analysis suggests that ICE-PmuST394 is circulating both by clonal expansion and horizontal transfer but is currently restricted to a single feedlot in Australia. Conclusions
Roy, R, Chick, P, York, E & Rawling, T 2024, 'Cytotoxicity of acridinium-based ionic liquids: Structure-activity relationship and mechanistic studies', Chemico-Biological Interactions, vol. 396, pp. 111042-111042.
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Roy, R, York, E, Pacchini, E & Rawling, T 2024, 'Effects of cationic head group structure on cytotoxicity and mitochondrial actions of amphiphilic ionic liquids', Food and Chemical Toxicology, vol. 183, pp. 114202-114202.
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Ionic liquids (ILs) are a class of low melting point salts with physicochemical properties that make them suitable for a range of industrial applications. Accumulating evidence suggests that certain ILs are cytotoxic and potential environmental pollutants, thus understanding the structural features that promote IL cytotoxicity is important. Amphiphilic ionic liquids (AmILs), a class of ILs with lipophilic N-alkyl chains, containing aromatic head groups are generally more cytotoxic than their aliphatic counterparts, however the impact of other head group properties are less clear. This study therefore sought to provide new structure activity relationship (SAR) insights regarding the role of the cationic head group on AmIL cytotoxicity. A series of AmILs bearing a range of structurally diverse aromatic cations varying in size, charge, and lipophilicity was synthesised and screened against human MDA-MB-231 breast cancer cells. It was found that larger and more lipophilic head groups increased cytotoxicity, although the magnitude of the changes were modest. The mitochondrial effects of representative ILs were assessed. The AmILs induced mitochondrial dysfunction in MDA-MB-231 cells at cytotoxic concentrations, suggesting that they target mitochondria. The new SAR information from this study may assist in the design of AmILs with controlled cytotoxicity.
Roychowdhury, R, Ghatak, A, Kumar, M, Samantara, K, Weckwerth, W & Chaturvedi, P 2024, 'Accelerating wheat improvement through trait characterization: advances and perspectives', Physiologia Plantarum, vol. 176, no. 5.
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AbstractWheat (Triticum spp.) is a primary dietary staple food for humanity. Many wheat genetic resources with variable genomes have a record of domestication history and are widespread throughout the world. To develop elite wheat varieties, agronomical and stress‐responsive trait characterization is foremost for evaluating existing germplasm to promote breeding. However, genomic complexity is one of the primary impediments to trait mining and characterization. Multiple reference genomes and cutting‐edge technologies like haplotype mapping, genomic selection, precise gene editing tools, high‐throughput phenotyping platforms, high‐efficiency genetic transformation systems, and speed‐breeding facilities are transforming wheat functional genomics research to understand the genomic diversity of polyploidy. This review focuses on the research achievements in wheat genomics, the available omics approaches, and bioinformatic resources developed in the past decades. Advances in genomics and system biology approaches are highlighted to circumvent bottlenecks in genomic and phenotypic selection, as well as gene transfer. In addition, we propose conducting precise functional genomic studies and developing sustainable breeding strategies for wheat. These developments in understanding wheat traits have speed up the creation of high‐yielding, stress‐resistant, and nutritionally enhanced wheat varieties, which will help in addressing global food security and agricultural sustainability in the era of climate change.
Ruvindy, R, Ajani, PA, Ashlin, S, Hallegraeff, G, Klemm, K, Bolch, CJ, Ugalde, S, Van Asten, M, Woodcock, S, Tesoriero, M & Murray, SA 2024, 'An On-Farm Workflow for Predictive Management of Paralytic Shellfish Toxin-Producing Harmful Algal Blooms for the Aquaculture Industry', Environmental Science & Technology, vol. 58, no. 16, pp. 6924-6933.
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Ryder, WG, Levina, A, Graziotto, ME, Hawkins, BA, Hibbs, DE, New, EJ & Gale, PA 2024, 'Subcellular targeted anion transporters', Chem.
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Sadraeian, M, Kabakova, I, Zhou, J & Jin, D 2024, 'Virus inactivation by matching the vibrational resonance', Applied Physics Reviews, vol. 11, no. 2.
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Physical approaches based on irradiation provide advances for the prevention and treatment of viral infections, while recognizing that certain chemical inactivation techniques demonstrate significant effectiveness alongside physical methods. By generating resonant vibrations of complete virus particles, which are in the GHz range and quite high compared to that of human cells, viruses can be inactivated. Therefore, exposure to ultrasound waves or non-thermal microwaves with a suitable resonant frequency oscillating electric field holds the potential to neutralize the virus particle with no damage to human. The deactivation mechanism could be a result of the mechanical effect or oxidation stress, and in this article, we discuss the elucidation of these effects on the virus' structure. We also explore the current state and future prospects of the anti-viral methods based on acoustic cavitation via ultrasound and non-thermal microwave, addressing critical needs in virology.
Saha, M, Dittami, SM, Chan, CX, Raina, J, Stock, W, Ghaderiardakani, F, Valathuparambil Baby John, AM, Corr, S, Schleyer, G, Todd, J, Cardini, U, Bengtsson, MM, Prado, S, Skillings, D, Sonnenschein, EC, Engelen, AH, Wang, G, Wichard, T, Brodie, J, Leblanc, C & Egan, S 2024, 'Progress and future directions for seaweed holobiont research', New Phytologist, vol. 244, no. 2, pp. 364-376.
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SummaryIn the marine environment, seaweeds (i.e. marine macroalgae) provide a wide range of ecological services and economic benefits. Like land plants, seaweeds do not provide these services in isolation, rather they rely on their associated microbial communities, which together with the host form the seaweed holobiont. However, there is a poor understanding of the mechanisms shaping these complex seaweed–microbe interactions, and of the evolutionary processes underlying these interactions. Here, we identify the current research challenges and opportunities in the field of seaweed holobiont biology. We argue that identifying the key microbial partners, knowing how they are recruited, and understanding their specific function and their relevance across all seaweed life history stages are among the knowledge gaps that are particularly important to address, especially in the context of the environmental challenges threatening seaweeds. We further discuss future approaches to study seaweed holobionts, and how we can apply the holobiont concept to natural or engineered seaweed ecosystems.
Sais, D, Chowdhury, S, Dalton, JP, Tran, N & Donnelly, S 2024, 'Both host and parasite non-coding RNAs co-ordinate the regulation of macrophage gene expression to reduce pro-inflammatory immune responses and promote tissue repair pathways during infection with fasciola hepatica', RNA Biology, vol. 21, no. 1, pp. 62-77.
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Salih, AK, Aditya, L, Matar, F, Nghiem, LD & Ton-That, C 2024, 'Improved flux and anti-fouling performance of a photocatalytic ZnO membrane on porous stainless steel substrate for microalgae harvesting', Journal of Membrane Science, vol. 694, pp. 122405-122405.
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Salih, AK, Khan, AZ, Drmosh, Q, Kandiel, T, Qamar, M, Jahangir, T, Ton-That, C & Yamani, Z 2024, 'Nanostructured BiVO4 Photoanodes Fabricated by Vanadium-Infused Interaction for Efficient Solar Water Splitting', ACS Applied Nano Materials, vol. 7, no. 12, pp. 14115-14122.
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Sasaki, M, Kingsbury, KM, Booth, DJ & Nagelkerken, I 2024, 'Body size mediates trophic interaction strength of novel fish assemblages under climate change', Journal of Animal Ecology, vol. 93, no. 6, pp. 705-714.
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AbstractEcological similarity plays an important role in biotic interactions. Increased body size similarity of competing species, for example, increases the strength of their biotic interactions. Body sizes of many exothermic species are forecast to be altered under global warming, mediating shifts in existing trophic interactions among species, in particular for species with different thermal niches.Temperate rocky reefs along the southeast coast of Australia are located in a climate warming hotspot and now house a mixture of temperate native fish species and poleward range‐extending tropical fishes (vagrants), creating novel species assemblages. Here, we studied the relationship between body size similarity and trophic overlap between individual temperate native and tropical vagrant fishes.Dietary niche overlap between vagrant and native fish species increased as their body sizes converged, based on both stomach content composition (short‐term diet), stable isotope analyses (integrated long‐term diet) and similarity in consumed prey sizes.We conclude that the warming‐induced faster growth rates of tropical range‐extending fish species at their cool water ranges will continue to converge their body size towards and strengthen their degree of trophic interactions and dietary overlap with co‐occurring native temperate species under increasing ocean warming. The strengthening of these novel competitive interactions is likely to drive changes to temperate food web structures and reshuffle existing species community structures.
Sasaki, M, Mitchell, A, Booth, DJ & Nagelkerken, I 2024, 'Novel ecological interactions alter physiological responses of range-extending tropical and local temperate fishes under ocean warming', Science of The Total Environment, vol. 913, pp. 169413-169413.
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Sasaki, M, Monaco, CJ, Booth, DJ & Nagelkerken, I 2024, 'Ocean warming and novel species interactions boost growth and persistence of range‐extending tropical fishes but challenge that of sympatric temperate species in temperate waters', Journal of Biogeography, vol. 51, no. 11, pp. 2243-2258.
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AbstractAimClimate change can have a broad range of impacts on the physiology and behaviour of animals. These effects can be mediated by the presence of other species in the community, but current forecasts of species responses to climate change largely ignore biological interactions. This is particularly true for novel interactions between range‐extending and native species, as this is often considered as noise and excluded from predictive models. Here we simulate how a tropical range‐extending and a local temperate fish species respond to the independent and combined effects of future ocean warming (RCPs 4.5 and 8.5) and novel ecological interactions in temperate ecosystems.LocationEast coast of Australia, along a ~ 2,000 km latitudinal gradient in a global climate warming hotspot.TaxonAbudefduf vaigiensis (tropical) and Atypicthys strigatus (temperate) fishes.MethodsWe use a dynamic energy budget model to simulate the length growth (i.e., increases in body length of individuals over time) and population persistence of juveniles of a tropical and a temperate fish species that form mixed‐species shoals, under different climate scenarios with and without the effects of novel ecological interactions.ResultsOur model forecasts that length growth of the juvenile tropical species will increase under ocean warming across subtropical to temperate regions. This increased length growth will be more drastic in temperate regions than in the subtropics, as winter warming will allow the tropical species to overwinter more frequently and show positive growth throughout the year. In contrast, warmer ...
Saunders, M, Spindler, X & Roux, C 2024, 'Fibre persistence on submerged substrates: The effect of flow rate over extended submersion periods', Forensic Science International, vol. 361, pp. 112137-112137.
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Scanes, E, Kutti, T, Fang, JKH, Johnston, EL, Ross, PM & Bannister, RJ 2024, 'The long-lived deep-sea bivalve Acesta excavata is sensitive to the dual stressors of sediment and warming', Marine Pollution Bulletin, vol. 202, pp. 116323-116323.
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Scardifield, K, McLean, N, Kuzhiumparambil, U, Ralph, PJ, Neveux, N, Isaac, G & Schork, T 2024, 'Biomasonry products from macroalgae: A design driven approach to developing biomaterials for carbon storage', Journal of Applied Phycology, vol. 36, no. 2, pp. 935-950.
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AbstractLowering the embodied carbon of building materials requires a transition away from fossil derived products towards bio-based alternatives, alongside the design and development of new clean tech biomaterials that can function as carbon sinks. This paper presents an overview of historical and existing uses of seaweeds in construction to identify gaps and opportunities for the development of seaweed-based construction materials that can support atmospheric carbon removal through algal photosynthesis. This study highlights the value of interdisciplinary research collaborations that can be situated within the expanding field of biodesign where design research and methods are used to influence the development materials science. It presents as a case study the design of seaweed bricks utilising a biorefinery framework that aims to valorise residual seaweed biomass being grown for waste-water management, identifying value-adding opportunities for this seaweed by-product and new possibilities for carbon storage in the built environment. It details the development of a 1:1 scale prototype for the purposes of an exhibition at the Art Gallery of South Australia in order to demonstrate what biomasonry products from macroalgae can look like, to build social acceptance and to encourage future uptake of sustainable seaweed construction products.
Schlotheuber, M, Voolstra, CR, de Beer, D, Camp, EF, Klatt, JM, Ghilardi, M, Neumüller, K, Ousley, S & Bejarano, S 2024, 'High temporal resolution of hydrogen peroxide (H2O2) dynamics during heat stress does not support a causative role in coral bleaching', Coral Reefs, vol. 43, no. 1, pp. 119-133.
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AbstractHuman-induced climate change is causing ocean warming that triggers the breakdown of the coral–algal symbiosis. The proximate cause of this phenomenon, known as coral bleaching, is commonly attributed to the overproduction of reactive oxygen species (ROS) by the thermally stressed photosynthetic algal symbionts. However, direct evidence that algal ROS production (e.g., in the form of H2O2) and coral physiological stress are the ultimate cause of bleaching remains ambiguous. Here, we investigated the temporal dynamics of H2O2 and oxygen (O2) concentrations during thermally induced coral bleaching to disentangle cause from consequence. Microsensors at the tissue interface of Pocillopora damicornis measured H2O2 and O2 concentrations while exposing single nubbins to baseline temperatures (30 °C) and to minor (33 °C), moderate (36 °C), and high (39 °C) levels of acute heat stress using the Coral Bleaching Automated Stress System (CBASS). We show that a temporary decline in O2 concentration, accompanied by a declining photosynthetic efficiency and loss of Symbiodiniaceae and pigmentation, is the initial response to moderate thermal stress. This response was neither provoked nor followed by an increased H2O2 concentration at the coral tissue interface. A steady light-independent increase of H2O2 was only detected during high heat stress, resulting in the complete and permanent loss of photosynthetic activity. Our findings do not support a direct connection between algal photodamage and an increase in H2O2 concentration during thermally induced bleaching and suggest that more research...
Scognamiglio, D, Gale, A, Al-Juboori, A, Toth, M & Aharonovich, I 2024, 'On-demand quantum light sources for underwater communications', Materials for Quantum Technology, vol. 4, no. 2, pp. 025402-025402.
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Abstract Quantum communication has been at the forefront of modern research for decades, however it is severely hampered in underwater applications, where the properties of water absorb nearly all useful optical wavelengths and prevent them from propagating more than, in most cases, a few metres. This research reports on-demand quantum light sources, suitable for underwater optical communication. The single photon emitters, which can be engineered using an electron beam, are based on impurities in hexagonal boron nitride. They have a zero phonon line at ∼436 nm, near the minimum value of water absorption and are shown to suffer negligible transmission and purity loss when travelling through water channels. These emitters are also shown to possess exceptional underwater transmission properties compared to emitters at other optical wavelengths and are utilised in a completely secure quantum key distribution experiment with rates of kbits s−1.
Scott, JA, Bishop, J, Budnik, G & Toth, M 2024, 'Hydrogen Plasma Inhibits Ion Beam Restructuring of GaP', ACS Applied Materials & Interfaces, vol. 16, no. 39, pp. 53116-53122.
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Focused ion beam (FIB) techniques are employed widely for nanofabrication and processing of materials and devices. However, ion irradiation often gives rise to severe damage due to atomic displacements that cause defect formation, migration, and clustering within the ion-solid interaction volume. The resulting restructuring degrades the functionality of materials and limits the utility of FIB ablation and nanofabrication techniques. Here we show that such restructuring can be inhibited by performing FIB irradiation in a hydrogen plasma environment via chemical pathways that modify defect binding energies and transport kinetics, as well as material ablation rates. The method is minimally invasive and has the potential to greatly expand the utility of FIB nanofabrication techniques in processing functional materials and devices.
Scott, RI, Edmondson, J, Camp, EF, Agius, T, Coulthard, P, Edmondson, J, Edmondson, K, Hosp, R, Howlett, L, Roper, CD & Suggett, DJ 2024, 'Cost‐effectiveness of tourism‐led coral planting at scale on the northern Great Barrier Reef', Restoration Ecology, vol. 32, no. 4.
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Stakeholder‐led coral reef restoration efforts, aimed at locally retaining or rebuilding coral populations, have rapidly grown over the last two decades. However, the cost‐effectiveness—and in turn viability—of coral restoration projects remains rarely reported. We therefore evaluated coral planting (often termed “outplanting”) cost‐effectiveness across the first 3.5 years of the Coral Nurture Program (CNP), a coral restoration approach integrated within tourism operations on Australia's Great Barrier Reef. CNP operator activity reporting forms (63,632 corals planted, 5 tourism operators, and 23 reef sites) were used to opportunistically calculate coral planting costs (PC; US$ coral−1 trip−1) for “routine” planting versus when additional stewardship activities—that regulate planting effectiveness—were undertaken (e.g., nursery maintenance). Mean PC (±standard error) was US$2.34 ± 0.20 coral−1 trip−1 (ranging US$0.78–6.03, 5th–95th percentile), but increased 2‐ to ‐6‐fold on trips where nursery propagation, site maintenance, or staff training was conducted to support planting efforts. The “realized” cost (PCR) of establishing coral biomass was subsequently determined by evaluating survivorship of planted corals across space (9 sites, single survey timepoint, n = 4,723 corals up to 3 years old) or over time (2 sites, over 9–12 months, n = 600 corals), resulting in costs increasing from PC to PCR by 25–71%. We demonstrate how integration of practices into tourism operations creates potential for cost‐effective coral planting at “high‐value” tourism reef sites, and discuss important steps for improving cost‐accounting in stakeholder‐led restoration programs that may be similarly positioned to routinely determine their cost‐effectiveness.
Seckiner, D, Mallett, X, Roux, C, Gittelson, S, Maynard, P & Meuwly, D 2024, 'Forensic interpretation framework for body and gait analysis: feature extraction, frequency and distinctiveness', Australian Journal of Forensic Sciences, vol. 56, no. 4, pp. 338-354.
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Seymour, JR, Brumley, DR, Stocker, R & Raina, J-B 2024, 'Swimming towards each other: the role of chemotaxis in bacterial interactions', Trends in Microbiology, vol. 32, no. 7, pp. 640-649.
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Shams-White, MM, Thompson, EC, Carroll, RJ & Reedy, J 2024, 'Methodological examination of the 2018 World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) Score', American Journal of Epidemiology, vol. 193, no. 8, pp. 1137-1145.
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Abstract The objective of this study was to examine the impact of methodological changes to the 2018 World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) Score on associations with risk for all-cause mortality, cancer mortality, and cancer risk jointly among older adults in the National Institutes of Health (NIH)-AARP Diet and Health Study. Weights were incorporated for each score component; a continuous point scale was developed in place of the score’s fully discrete cut points; and cut-point values were changed for physical activity and red meat based on evidence-based recommendations. Exploratory aims also examined the impact of separating components with more than one subcomponent and whether all components were necessary to retain within this population utilizing a penalized scoring approach. Findings suggested weighting the original 2018 WCRF/AICR Score improved its predictive performance in association with all-cause mortality and provided more precise estimates in relation to cancer risk and mortality outcomes. The importance of healthy weight, physical activity, and plant-based foods in relation to cancer and overall mortality risk were highlighted in this population of older adults. Further studies are needed to better understand the consistency and generalizability of these findings across other populations.
Shan, X, Ding, L, Wang, D, Wen, S, Shi, J, Chen, C, Wang, Y, Zhu, H, Huang, Z, Wang, SSJ, Zhong, X, Liu, B, Reece, PJ, Ren, W, Hao, W, Lu, X, Lu, J, Su, QP, Chang, L, Sun, L, Jin, D, Jiang, L & Wang, F 2024, 'Author Correction: Sub-femtonewton force sensing in solution by super-resolved photonic force microscopy', Nature Photonics, vol. 18, no. 9, pp. 998-998.
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Shan, X, Ding, L, Wang, D, Wen, S, Shi, J, Chen, C, Wang, Y, Zhu, H, Huang, Z, Wang, SSJ, Zhong, X, Liu, B, Reece, PJ, Ren, W, Hao, W, Lu, X, Lu, J, Su, QP, Chang, L, Sun, L, Jin, D, Jiang, L & Wang, F 2024, 'Sub-femtonewton force sensing in solution by super-resolved photonic force microscopy', Nature Photonics, vol. 18, no. 9, pp. 913-921.
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Shi, Q, Wang, G, Wang, S, Zhang, C, Wei, Z, Guo, Z, Zhang, D, Yun, K & Fu, S 2024, 'Liquid chromatography with tandem mass spectrometric method for determination of 52 antibiotics in human whole blood and urine and application to forensic cases', Forensic Toxicology, vol. 42, no. 2, pp. 202-211.
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Shrestha, J, Limbu, KR, Chhetri, RB, Paudel, KR, Hansbro, PM, Oh, YS, Baek, DJ, Ki, S-H & Park, E-Y 2024, 'Antioxidant genes in cancer and metabolic diseases: Focusing on Nrf2, Sestrin, and heme oxygenase 1', International Journal of Biological Sciences, vol. 20, no. 12, pp. 4888-4907.
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Siboni, N, King, WL, Williams, NLR, Scanes, E, Giardina, M, Green, TJ, Ostrowski, M, O'Connor, W, Dove, M, Labbate, M & Seymour, JR 2024, 'Increased abundance of potentially pathogenic Vibrio and a marine heatwave co-occur with a Pacific Oyster summer mortality event', Aquaculture, vol. 583, pp. 740618-740618.
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Siddique, MAB, Imran, M, Haider, A, Shahzadi, A, Ul-Hamid, A, Nabgan, W, Batool, M, Khan, K, Ikram, M, Somaily, HH & Mahmood, A 2024, 'Enhancing catalytic and antibacterial activity with size-controlled yttrium and graphene quantum dots doped MgO nanostructures: A molecular docking analysis', Materials Today Sustainability, vol. 25, pp. 100690-100690.
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Sim, DZH, Mowe, MAD, Mitrovic, SM, Tulsian, NK, Anand, GS & Yeo, DCJ 2024, 'Nutrient conditions influence allelopathic capabilities of Ludwigia adscendens and other tropical macrophytes against Microcystis aeruginosa', Freshwater Biology, vol. 69, no. 4, pp. 538-555.
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AbstractMacrophytes may release allelochemicals that suppress competing phytoplankton, although it is unclear how their effectiveness could be influenced by environmental nutrient conditions. To approach this, we conducted a series of bioassays against the bloom‐forming cyanobacterium Microcystis aeruginosa using extracts and exudates from potentially allelopathic macrophytes under varying nutrient conditions.We screened six different tropical macrophytes and identified antialgal effects in both extracts and exudates of Ludwigia adscendens, Persicaria barbata, Pontederia crassipes and Vallisneria spiralis. Growth assays indicated that extract inhibitory effectiveness decreased as nutrient concentration increased from 5% to 50% strength.Focusing on the potent antialgal extract of L. adscendens, we determined that its inhibitory effects were enhanced by specifically reducing the availability of either micronutrient or bicarbonate availability, indicating a role of these nutrients in protecting algal cells from allelochemicals.Bioactivity‐guided fractionation and ultra‐performance liquid chromatography – mass spectrometry analyses of L. adscendens extract indicated that ellagitannins were the major constituent of bioactive extract fractions, suggesting an antialgal mechanism common to other tannic compounds. Novel allelopathic alkaloids and terpenoid compounds also were described, although their mechanisms of action are unknown.Our findings provide evidence that the availability of carbon and micr...
Singh, M, De Rubis, G, Kokkinis, S, Paudel, KR, Yeung, S, Hansbro, PM, Oliver, BGG & Dua, K 2024, 'Curcumin-loaded liposomes modulating the synergistic role of EpCAM and estrogen receptor alpha in lung cancer management', Pathology - Research and Practice, vol. 257, pp. 155317-155317.
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Singh, M, Zakria, M, Pannu, AS, Sonar, P, Smith, C, Mahasivam, S, Ramanathan, R, Tran, K, Tawfik, S, Murdoch, BJ, Mayes, ELH, Spencer, MJS, Phillips, MR, Bansal, V & Ton-That, C 2024, 'Defect-Free, Few-Atomic-Layer Thin ZnO Nanosheets with Superior Excitonic Properties for Optoelectronic Devices', ACS Nano, vol. 18, no. 26, pp. 16947-16957.
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Singh, S, Saxena, S, Sharma, H, Paudel, KR, Chakraborty, A, MacLoughlin, R, Oliver, BG, Gupta, G, Negi, P, Singh, SK & Dua, K 2024, 'Emerging role of tumor suppressing microRNAs as therapeutics in managing non-small cell lung cancer', Pathology - Research and Practice, vol. 256, pp. 155222-155222.
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Singh, S, Sharma, K & Kumar, M 2024, 'Elucidating molecular interaction leading to successful grafting of in vitro regenerated shoots of three chickpea (Cicer arietinum L.) cultivars', Plant Cell, Tissue and Organ Culture (PCTOC), vol. 159, no. 1.
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Sofian, M, Nasim, F, Ali, H, Kanodarwala, FK & Nadeem, MA 2024, 'Efficient formic acid oxidation over gallium oxide incorporated Pd containing electrocatalyst', International Journal of Hydrogen Energy, vol. 51, pp. 1277-1285.
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Solanki, N, Gupta, G, Chellappan, DK, Singh, SK, Gulati, M, Paudel, KR, Hansbro, PM, Dua, K, Bhan, S, Saini, M & Dureja, H 2024, 'Boswellic Acids: A Critical Appraisal of Their Therapeutic and Nutritional Benefits in Chronic Inflammatory Diseases', Endocrine, Metabolic & Immune Disorders - Drug Targets, vol. 24, no. 1, pp. 116-129.
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Background:In the last few decades, it has been largely perceived that the factors affecting the immune system and its varying pathways lead to the pathological progression of inflammation and inflammatory conditions. Chronic inflammation also contributes to common diseases, such as diabetes mellitus, ischemic heart disease, cancer, chronic renal inflammatory disease, non-alcoholic fatty hepat-ic disease, autoimmune diseases and neurodegenerative diseases.Objective:Interestingly, plant sources and secondary metabolites from plants have been increasingly employed in managing acute and chronic inflammatory diseases for centuries. Boswellic acids are pentacyclic triterpenoidal moieties obtained from the oleo gum resin of different Boswellia species.Methods:Detailed data was collected revealing the anti-inflammatory potential of Boswellic acids through various databases.Results:These are pharmacologically active agents that possess promising anti-inflammatory, anti-arthritic, antirheumatic, anti-diarrheal, anti-hyperlipidemic, anti-asthmatic, anti-cancer, and anti-microbial effects.Conclusion:Boswellic acids have been in use since ancient times primarily to treat acute and chronic inflammatory diseases. This review discusses the various mechanisms underlying the inflammatory process and the necessity of such natural products as a medication to treat inflammatory diseases. In addition, a discussion has also been extended to understand the primary targets involved in inflamma-tion. The review further explores the therapeutic potential of boswellic acids in
Spina, N, Raimondi, M, Castorina, A, Ragonese, E & Palmisano, G 2024, 'A Three-Channel Package-Scale Galvanic Isolation Interface for Wide Bandgap Gate Drivers', IEEE Transactions on Very Large Scale Integration (VLSI) Systems, vol. 32, no. 8, pp. 1389-1399.
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Stern, HL, M. Gilardoni, C, Gu, Q, Eizagirre Barker, S, Powell, OFJ, Deng, X, Fraser, SA, Follet, L, Li, C, Ramsay, AJ, Tan, HH, Aharonovich, I & Atatüre, M 2024, 'A quantum coherent spin in hexagonal boron nitride at ambient conditions', Nature Materials, vol. 23, no. 10, pp. 1379-1385.
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AbstractSolid-state spin–photon interfaces that combine single-photon generation and long-lived spin coherence with scalable device integration—ideally under ambient conditions—hold great promise for the implementation of quantum networks and sensors. Despite rapid progress reported across several candidate systems, those possessing quantum coherent single spins at room temperature remain extremely rare. Here we report quantum coherent control under ambient conditions of a single-photon-emitting defect spin in a layered van der Waals material, namely, hexagonal boron nitride. We identify that the carbon-related defect has a spin-triplet electronic ground-state manifold. We demonstrate that the spin coherence is predominantly governed by coupling to only a few proximal nuclei and is prolonged by decoupling protocols. Our results serve to introduce a new platform to realize a room-temperature spin qubit coupled to a multiqubit quantum register or quantum sensor with nanoscale sample proximity.
Stone, DG, Whitefield, B, Kianinia, M & Bradac, C 2024, 'Fast Characterization of Optically Detected Magnetic Resonance Spectra via Data Clustering', The Journal of Physical Chemistry C, vol. 128, no. 31, pp. 13147-13154.
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Strader, ME, Wright, RM, Pezner, AK, Nuttall, MF, Aichelman, HE & Davies, SW 2024, 'Intersection of coral molecular responses to a localized mortality event and ex situ deoxygenation', Ecology and Evolution, vol. 14, no. 4.
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AbstractIn July 2016, East Bank of Flower Garden Banks (FGB) National Marine Sanctuary experienced a localized mortality event (LME) of multiple invertebrate species that ultimately led to reductions in coral cover. Abiotic data taken directly after the event suggested that acute deoxygenation contributed to the mortality. Despite the large impact of this event on the coral community, there was no direct evidence that this LME was driven by acute deoxygenation, and thus we explored whether gene expression responses of corals to the LME would indicate what abiotic factors may have contributed to the LME. Gene expression of affected and unaffected corals sampled during the mortality event revealed evidence of the physiological consequences of the LME on coral hosts and their algal symbionts from two congeneric species (Orbicella franksi and Orbicella faveolata). Affected colonies of both species differentially regulated genes involved in mitochondrial regulation and oxidative stress. To further test the hypothesis that deoxygenation led to the LME, we measured coral host and algal symbiont gene expression in response to ex situ experimental deoxygenation (control = 6.9 ± 0.08 mg L−1, anoxic = 0.083 ± 0.017 mg L−1) in healthy O. faveolata colonies from the FGB. However, this deoxygenation experiment revealed divergent gene expression patterns compared to the corals sampled during the LME and was more similar to a generalized coral environmental stress response. It is therefore likely that while the LME was connected to low oxygen, it was a series of interconnected stressors that elicited the unique gene expression responses observed here. These in situ and ex situ data highlight how field responses to stressors are unique from those in controlled laboratory conditions, and that the complexities of deoxy...
Strange, N, Luu, L, Ong, V, Wee, BA, Phillips, MJA, McCaughey, L, Steele, JR, Barlow, CK, Cranfield, CG, Myers, G, Mazraani, R, Rock, C, Timms, P & Huston, WM 2024, 'HtrA, fatty acids, and membrane protein interplay in Chlamydia trachomatis to impact stress response and trigger early cellular exit', Journal of Bacteriology, vol. 206, no. 4.
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ABSTRACT Chlamydia trachomatis is an intracellular bacterial pathogen that undergoes a biphasic developmental cycle, consisting of intracellular reticulate bodies and extracellular infectious elementary bodies. A conserved bacterial protease, HtrA, was shown previously to be essential for Chlamydia during the reticulate body phase, using a novel inhibitor (JO146). In this study, isolates selected for the survival of JO146 treatment were found to have polymorphisms in the acyl-acyl carrier protein synthetase gene ( aasC ) . AasC encodes the enzyme responsible for activating fatty acids from the host cell or synthesis to be incorporated into lipid bilayers. The isolates had distinct lipidomes with varied fatty acid compositions. A reduction in the lipid compositions that HtrA prefers to bind to was detected, yet HtrA and MOMP (a key outer membrane protein) were present at higher levels in the variants. Reduced progeny production and an earlier cellular exit were observed. Transcriptome analysis identified that multiple genes were downregulated in the variants especially stress and DNA processing factors. Here, we have shown that the fatty acid composition of chlamydial lipids, HtrA, and membrane proteins interplay and, when disrupted, impact chlamydial stress response that could trigger early cellular exit. IMPORTANCE Chlamydia trachomatis is an important obligate intracellular pathogen that has a unique biphasic developmental cycle. HtrA is an essential stress or virulence...
Stringer, A, Akkaya Hocagil, T, Cook, RJ, Ryan, LM, Jacobson, SW & Jacobson, JL 2024, 'Semi-parametric benchmark dose analysis with monotone additive models', Biometrics, vol. 80, no. 3.
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Abstract Benchmark dose analysis aims to estimate the level of exposure to a toxin associated with a clinically significant adverse outcome and quantifies uncertainty using the lower limit of a confidence interval for this level. We develop a novel framework for benchmark dose analysis based on monotone additive dose-response models. We first introduce a flexible approach for fitting monotone additive models via penalized B-splines and Laplace-approximate marginal likelihood. A reflective Newton method is then developed that employs de Boor’s algorithm for computing splines and their derivatives for efficient estimation of the benchmark dose. Finally, we develop a novel approach for calculating benchmark dose lower limits based on an approximate pivot for the nonlinear equation solved by the estimated benchmark dose. The favorable properties of this approach compared to the Delta method and a parameteric bootstrap are discussed. We apply the new methods to make inferences about the level of prenatal alcohol exposure associated with clinically significant cognitive defects in children using data from six NIH-funded longitudinal cohort studies. Software to reproduce the results in this paper is available online and makes use of the novel semibmd R package, which implements the methods in this paper.
Strudwick, P, Camp, EF, Seymour, J, Roper, C, Edmondson, J, Howlett, L & Suggett, DJ 2024, 'Impacts of plastic‐free materials on coral‐associated bacterial communities during reef restoration', Environmental Microbiology Reports, vol. 16, no. 1.
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AbstractCoral propagation and out‐planting based restoration approaches are increasingly being applied to assist natural recovery of coral reefs. However, many restoration methods rely on plastic zip‐ties to secure coral material which is potentially problematic for the marine environment. Plastic‐free biodegradable alternatives may however pose unique risks to coral‐associated bacterial communities integral to coral health. Therefore, to identify whether biodegradable materials differentially impact coral‐associated bacterial communities we examined Acropora millepora coral‐associated bacterial communities during propagation in two experiments on the Great Barrier Reef. Coral fragments were secured to coral nurseries with conventional plastic, metal, or biodegradable (polyester and polycaprolactone) ties. Tie failure and coral‐associated bacterial communities were then characterized over six months. Minimal coral mortality was observed (3.6%–8%) and all ties had low failure rates (0%–4.2%) except for biodegradable polyester ties (29.2% failure). No differences were observed between coral‐associated bacterial communities of fragments secured with different ties, and no proliferation of putatively pathogenic bacteria was recorded. Overall, our findings suggest that reducing reliance on conventional plastic is feasible through transitions to biodegradable materials, without any notable impacts on coral‐associated bacterial communities. However, we caution the need to examine more coral taxa of different morphologies and new plastic‐free materials prior to application.
Stuart, B, Frankham, GJ, Mangion, G & Ueland, M 2024, 'A rapid and non-destructive identification method for tortoiseshell products using attenuated total reflectance infrared spectroscopy', Forensic Science International: Animals and Environments, vol. 5, pp. 100079-100079.
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Stuart, B, Guan, J, Collins, S, Thomas, P & Ueland, M 2024, 'A preliminary study of non-woven fabrics for forensic identification purposes', Australian Journal of Forensic Sciences, vol. 56, no. 2, pp. 144-153.
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While traditional woven textiles have been the subject of many forensic investigations, non-woven fabrics have received minimal attention thus far. Given the expansion of commercial applications of non-woven fabrics, a preliminary investigation of household wipes has been carried out to characterize the compositions of these widely available non-woven fabrics. Infrared spectroscopy and thermogravimetric analysis were employed to identify the fibre type and additives of three types of commercial wipes. Polyester and/or viscose fibres were found to be the main components and, along with the identification of binders, enable source types to be differentiated. The predicted different sensitivities of the fibre types to biodeterioration highlights the importance of future environmental studies for the correct characterization of non-woven fabrics in evidence.
Stylianou, N, Sebina, I, Matigian, N, Monkman, J, Doehler, H, Röhl, J, Allenby, M, Nam, A, Pan, L, Rockstroh, A, Sadeghirad, H, Chung, K, Sobanski, T, O'Byrne, K, Almeida, ACSF, Rebutini, PZ, Machado‐Souza, C, Stonoga, ETS, Warkiani, ME, Salomon, C, Short, K, McClements, L, de Noronha, L, Huang, R, Belz, GT, Souza‐Fonseca‐Guimaraes, F, Clifton, V & Kulasinghe, A 2024, 'Whole transcriptome profiling of placental pathobiology in SARS‐CoV‐2 pregnancies identifies placental dysfunction signatures', Clinical & Translational Immunology, vol. 13, no. 2.
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AbstractObjectivesSevere Acute Respiratory Syndrome Coronavirus 2 (SARS‐CoV‐2) virus infection in pregnancy is associated with higher incidence of placental dysfunction, referred to by a few studies as a ‘preeclampsia‐like syndrome’. However, the mechanisms underpinning SARS‐CoV‐2‐induced placental malfunction are still unclear. Here, we investigated whether the transcriptional architecture of the placenta is altered in response to SARS‐CoV‐2 infection.MethodsWe utilised whole‐transcriptome, digital spatial profiling, to examine gene expression patterns in placental tissues from participants who contracted SARS‐CoV‐2 in the third trimester of their pregnancy (n = 7) and those collected prior to the start of the coronavirus disease 2019 (COVID‐19) pandemic (n = 9).ResultsThrough comprehensive spatial transcriptomic analyses of the trophoblast and villous core stromal cell subpopulations in the placenta, we identified SARS‐CoV‐2 to promote signatures associated with hypoxia and placental dysfunction. Notably, genes associated with vasodilation (NOS3), oxidative stress (GDF15, CRH) and preeclampsia (FLT1, EGFR, KISS1, PAPPA2) were enriched with SARS‐CoV‐2. Pathways related to increased nutrient uptake, vascular tension, hypertension and inflammation were also enriched in SARS‐CoV‐2 samples compared to uninfected controls.ConclusionsOur findings demonstrate the utility of spatially resolved transcriptomic analysis in defining the underlying pathogenic mechanisms of S...
Su, C, Janzen, E, He, M, Li, C, Zettl, A, Caldwell, JD, Edgar, JH & Aharonovich, I 2024, 'Fundamentals and emerging optical applications of hexagonal boron nitride: a tutorial', Advances in Optics and Photonics, vol. 16, no. 2, pp. 229-229.
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Hexagonal boron nitride (hBN), also known as white graphite, is a transparent layered crystal with a wide bandgap. Its crystal structure resembles graphite, featuring layers composed of honeycomb lattices held together through van der Waals forces. The layered crystal structure of hBN facilitates exfoliation into thinner flakes and makes it highly anisotropic in in-plane and out-of-plane directions. Unlike graphite, hBN is both insulating and transparent, making it an ideal material for isolating devices from the environment and acting as a waveguide. As a result, hBN has found extensive applications in optical devices, electronic devices, and quantum photonic devices. This comprehensive tutorial aims to provide readers with a thorough understanding of hBN, covering its synthesis, lattice and spectroscopic characterization, and various applications in optoelectronic and quantum photonic devices. This tutorial is designed for both readers without prior experience in hBN and those with expertise in specific fields seeking to understand its relevance and connections to others.
Su, F, Chen, S, Liu, Y, Zhou, J, Du, Z, Luo, X, Wen, S & Jin, D 2024, 'Lanthanide Complex for Single-Molecule Fluorescent in Situ Hybridization and Background-Free Imaging', Analytical Chemistry, vol. 96, no. 11, pp. 4430-4436.
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Sullivan, E, Zeki, R, Ward, S, Sherwood, J, Remond, M, Chang, S, Kypri, K & Brown, J 2024, 'Effects of the Connections program on return‐to‐custody, mortality and treatment uptake among people with a history of opioid use: Retrospective cohort study in an Australian prison system', Addiction, vol. 119, no. 1, pp. 169-179.
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AbstractBackground and AimsConnections is a voluntary health program that facilitates access to opioid agonist treatment (OAT) and social services for people with opioid use exiting prison. This study aimed to measure the effectiveness of Connections in reducing recidivism and improving health outcomes for people with a history of opioid use on leaving prison.DesignRetrospective cohort study with quasi‐random allocation to the program.SettingPublic adult prisons in New South Wales, Australia, 2008–2015.ParticipantsAdults released from custody with a history of opioid use. Of 5549 eligible releasees, 3973 were allocated to Connections and 1576 to treatment‐as‐usual.MeasurementsOutcomes were return‐to‐custody, all‐cause mortality, and OAT participation.FindingsRegression analyses on an intention‐to‐treat basis, and adjusting for baseline propensity scores, comparing patients allocated to Connections versus treatment‐as‐usual showed no difference in rates of return‐to‐custody within 2 years (hazard ratio [HR]: 1.01; 95% confidence interval [CI]: 0.92 –1.12). Patients allocated to the Connections program were more likely to access OAT (odds ratio [OR]: 1.21; 95% CI: 1.06–1.39) and had lower mortality within 28 days of release (0.25% vs. 0.66%; HR: 0.38; 95% CI: 0.14–1.03). Differences in mortality did not persist beyond 28 days. Subgroup analyses showed that allocation to Connections was associated with higher risk of return‐to‐custody within 28 days for Aboriginal and/or Torres Strait Islander (Indigenous) and female releasees.Conclusions<...
Summers, BS, Thomas Broome, S, Pang, TWR, Mundell, HD, Koh Belic, N, Tom, NC, Ng, ML, Yap, M, Sen, MK, Sedaghat, S, Weible, MW, Castorina, A, Lim, CK, Lovelace, MD & Brew, BJ 2024, 'A Review of the Evidence for Tryptophan and the Kynurenine Pathway as a Regulator of Stem Cell Niches in Health and Disease', International Journal of Tryptophan Research, vol. 17.
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Stem cells are ubiquitously found in various tissues and organs in the body, and underpin the body’s ability to repair itself following injury or disease initiation, though repair can sometimes be compromised. Understanding how stem cells are produced, and functional signaling systems between different niches is critical to understanding the potential use of stem cells in regenerative medicine. In this context, this review considers kynurenine pathway (KP) metabolism in multipotent adult progenitor cells, embryonic, haematopoietic, neural, cancer, cardiac and induced pluripotent stem cells, endothelial progenitor cells, and mesenchymal stromal cells. The KP is the major enzymatic pathway for sequentially catabolising the essential amino acid tryptophan (TRP), resulting in key metabolites including kynurenine, kynurenic acid, and quinolinic acid (QUIN). QUIN metabolism transitions into the adjoining de novo pathway for nicotinamide adenine dinucleotide (NAD) production, a critical cofactor in many fundamental cellular biochemical pathways. How stem cells uptake and utilise TRP varies between different species and stem cell types, because of their expression of transporters and responses to inflammatory cytokines. Several KP metabolites are physiologically active, with either beneficial or detrimental outcomes, and evidence of this is presented relating to several stem cell types, which is important as they may exert a significant impact on surrounding differentiated cells, particularly if they metabolise or secrete metabolites differently. Interferon-gamma (IFN-γ) in mesenchymal stromal cells, for instance, highly upregulates rate-limiting enzyme indoleamine-2,3-dioxygenase (IDO-1), initiating TRP depletion and production of metabolites including kynurenine/kynurenic acid, known agonists of the Aryl hydrocarbon receptor (AhR) transcription factor. AhR transcriptionally regulates an immunosuppressive phenotype, making them attractive for regenera...
Summers, PK, Wuhrer, R & McDonagh, AM 2024, 'Electrically conductive gold films formed by sintering of gold nanoparticles at room temperature initiated by ozone', Journal of Nanoparticle Research, vol. 26, no. 5.
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AbstractUnderstanding and controlling the sintering behaviour of gold nanoparticles is important in the field of ligand-protected nanoparticles for their use as precursors for thin film fabrication. Lowering the temperature of the sintering event of gold nanoparticles by facilitating desorption of the ligand through oxidation can provide compatibility of sintered gold nanoparticle thin films onto heat-sensitive substrates. Here we examine the processes by which 1-butanethiol-protected gold nanoparticles sinter under an ozone-rich environment. Upon heating, an ozone-rich environment significantly reduces the temperature of the sintering event when compared to sintering under ambient conditions. At room temperature, exposure to an ozone-rich environment induces sintering over a period of 2.5 h. Upon exposure to ozone, the surface-bound butanethiol ligands are oxidised to 1-butanesulfonic acid which facilitates sintering.
Sun, B, Jing, R, Zeng, Y, Wei, W, Jin, X & Huang, B 2024, 'Three-side coordinated dispatching method for intelligent distribution network considering dynamic capacity division of shared energy storage system', Journal of Energy Storage, vol. 81, pp. 110406-110406.
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Suryana, E, Rowlands, BD, Bishop, DP, Finkelstein, DI & Double, KL 2024, 'Empirically derived formulae for calculation of age- and region-related levels of iron, copper and zinc in the adult C57BL/6 mouse brain', Neurobiology of Aging, vol. 136, pp. 34-43.
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Tambe, S, Das, SS, Shahane, K, Singh, SK, Ruokolainen, J, Amin, P & Kesari, KK 2024, 'First-order derivative spectrophotometric method for simultaneous determination of brinzolamide and timolol maleate in ophthalmic formulation', Green Analytical Chemistry, vol. 8, pp. 100098-100098.
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Taylor-Blair, HC, Siu, ACW, Haysom-McDowell, A, Kokkinis, S, Bani Saeid, A, Chellappan, DK, Oliver, BGG, Paudel, KR, De Rubis, G & Dua, K 2024, 'The impact of airborne particulate matter-based pollution on the cellular and molecular mechanisms in chronic obstructive pulmonary disease (COPD)', Science of The Total Environment, vol. 954, pp. 176413-176413.
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Thapa, R, Moglad, E, Afzal, M, Gupta, G, Bhat, AA, almalki, WH, Kazmi, I, Alzarea, SI, Pant, K, Ali, H, Paudel, KR, Dureja, H, Singh, TG, Singh, SK & Dua, K 2024, 'ncRNAs and their impact on dopaminergic neurons: Autophagy pathways in Parkinson's disease', Ageing Research Reviews, vol. 98, pp. 102327-102327.
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Thapa, R, Moglad, E, Goyal, A, Bhat, AA, Almalki, WH, Kazmi, I, Alzarea, SI, Ali, H, Oliver, BG, MacLoughlin, R, Dureja, H, Singh, SK, Dua, K & Gupta, G 2024, 'Deciphering NF-kappaB pathways in smoking-related lung carcinogenesis.', EXCLI J, vol. 23, pp. 991-1017.
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One of the main causes of death worldwide is lung cancer, which is largely caused by cigarette smoking. The crucial transcription factor NF-κB, which controls inflammatory responses and various cellular processes, is a constitutively present cytoplasmic protein strictly regulated by inhibitors like IκB proteins. Upon activation by external stimuli, it undergoes phosphorylation, translocates into the nucleus, and modulates the expression of specific genes. The incontrovertible association between pulmonary malignancy and tobacco consumption underscores and highlights a public health concern. Polycyclic aromatic hydrocarbons and nitrosamines, potent carcinogenic compounds present in the aerosol emitted from combusted tobacco, elicit profound deleterious effects upon inhalation, resulting in severe perturbation of pulmonary tissue integrity. The pathogenesis of smoking-induced lung cancer encompasses an intricate process wherein NF-κB activation plays a pivotal role, triggered by exposure to cigarette smoke through diverse signaling pathways, including those associated with oxidative stress and pro-inflammatory cytokines. Unraveling the participation of NF-κB in smoking-induced lung cancer provides pivotal insights into molecular processes, wherein intricate crosstalk between NF-κB and pathways such as MAPK and PI3K-Akt amplifies the inflammatory response, fostering an environment conducive to the formation of lung cancer. This study reviews the critical function of NF-κB in the complex molecular pathways linked to the initiation and advancement of lung carcinogenesis as well as potential treatment targets. See also the graphical abstract(Fig. 1).
Thurn, B, Deo, A, Patel, D, Sunnucks, E, Forbes, S, Stuart, BH, Su, S & Ueland, M 2024, 'Ante- and post-mortem human volatiles for disaster search and rescue', Forensic Chemistry, vol. 40, pp. 100596-100596.
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Thurn, B, Schotsmans, EMJ & Ueland, M 2024, 'Lime and odour: A preliminary investigation into the effect of hydrated lime on the volatiles emitted from human remains', Forensic Science International, vol. 358, pp. 111745-111745.
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Tian, X, Zhao, Q, Zhou, M, Huang, X, Sun, Y, Duan, X, Zhang, L, Li, H, Su, D, Jia, B & Ma, T 2024, 'Synergy of Dendrites‐Impeded Atomic Clusters Dissociation and Side Reactions Suppressed Inert Interface Protection for Ultrastable Zn Anode', Advanced Materials, vol. 36, no. 19.
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AbstractThe sluggish ions‐transfer and inhomogeneous ions‐nucleation induce the formation of randomly oriented dendrites on Zn anode, while the chemical instability at anode–electrolyte interface triggers detrimental side reactions. Herein, this report in situ designs a multifunctional hybrid interphase of Bi/Bi2O3, for the first time resulting in a novel synergistic regulation mechanism involving: (i) chemically inert interface protection mechanism suppresses side reactions; and more fantastically, (ii) innovative thermodynamically favorable Zn atomic clusters dissociation mechanism impedes dendrites formation. Assisted by collaborative modulation behavior, the Zn@Bi/Bi2O3 symmetry cell delivers an ultrahigh cumulative plating capacity of 1.88 Ah cm−2 at 5 mA cm−2 and ultralong lifetimes of 300 h even at high current density and depth of discharge (10 mA cm−2, DODZn: 60%). Furthermore, under a low electrolyte‐to‐capacity ratio (E/C: 45 µL mAh−1) and negative‐to‐positive capacity ratio (N/P: 6.3), Zn@Bi/Bi2O3||MnO2 full‐cell exhibits a superior capacity retention of 86.7% after 500 cycles at 1 A g−1, which outperforms most existing interphases. The scaled‐up Zn@Bi/Bi2O3||MnO2 battery module (6 V, 1 Ah), combined with the photovoltaic panel, presents excellent renewable‐energy storage ability and long output lifetime (12 h). This work provides a fantastic synergistic mechanism to achieve the ultrastable Zn anode and can be greatly promised to apply it into other metal‐based batteries.
Tobin, LA, Cain, AK, Djordjevic, SP & Hamidian, M 2024, 'Transposons Carrying the aacC2e Aminoglycoside and blaTEM Beta-Lactam Resistance Genes in Acinetobacter', Microbial Drug Resistance, vol. 30, no. 6, pp. 273-278.
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Tobin, LA, Jarocki, VM, Kenyon, J, Drigo, B, Donner, E, Djordjevic, SP & Hamidian, M 2024, 'Genomic analysis of diverse environmental Acinetobacter isolates identifies plasmids, antibiotic resistance genes, and capsular polysaccharides shared with clinical strains', Applied and Environmental Microbiology, vol. 90, no. 2.
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ABSTRACT Acinetobacter baumannii, an important pathogen known for its widespread antibiotic resistance, has been the focus of extensive research within its genus, primarily involving clinical isolates. Consequently, data on environmental A. baumannii and other Acinetobacter species remain limited. Here, we utilized Illumina and Nanopore sequencing to analyze the genomes of 10 Acinetobacter isolates representing 6 different species sourced from aquatic environments in South Australia. All 10 isolates were phylogenetically distinct compared to clinical and other non-clinical Acinetobacter strains, often tens of thousands of single-nucleotide polymorphisms from their nearest neighbors. Despite the genetic divergence, we identified p dif modules (sections of mobilized DNA) carrying clinically important antimicrobial resistance genes in species other than A. baumannii , including carbapenemase oxa58, tetracycline resistance gene tet(39 ), and macrolide resistance genes msr(E)-mph(E ). These p dif modules were located on plasmids with high sequence identity to those circulating in globally distributed A. baumannii ST1 and ST2 clones. The environmental A. baumannii is...
Ueland, M, Bae, H, Udomkijmongkol, A, Kotmool, K, Gulati, V & Hussain, T 2024, 'Single atom dispersed tungsten disulfide (WS2) based nanosensors for VOCs detection related to decomposed humans in disaster events', FlatChem, vol. 45, pp. 100666-100666.
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van den Berge, M & Faiz, A 2024, 'Blood Biomarkers of Emphysema: What Can They Really Tell Us?', American Journal of Respiratory and Critical Care Medicine, vol. 209, no. 3, pp. 235-237.
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Van Haeften, S, Campbell, BC, Milic, A, Addison-Smith, E, Al Kouba, J, Huete, A, Beggs, PJ & Davies, JM 2024, 'Environmental DNA analysis of airborne poaceae (grass) pollen reveals taxonomic diversity across seasons and climate zones', Environmental Research, vol. 247, pp. 117983-117983.
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Vettori, L, Tran, HA, Mahmodi, H, Filipe, EC, Wyllie, K, Liu Chung Ming, C, Cox, TR, Tipper, J, Kabakova, IV, Rnjak-Kovacina, J & Gentile, C 2024, 'Silk fibroin increases the elasticity of alginate-gelatin hydrogels and regulates cardiac cell contractile function in cardiac bioinks', Biofabrication, vol. 16, no. 3, pp. 035025-035025.
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Abstract Silk fibroin (SF) is a natural protein extracted from Bombyx mori silkworm thread. From its common use in the textile industry, it emerged as a biomaterial with promising biochemical and mechanical properties for applications in the field of tissue engineering and regenerative medicine. In this study, we evaluate for the first time the effects of SF on cardiac bioink formulations containing cardiac spheroids (CSs). First, we evaluate if the SF addition plays a role in the structural and elastic properties of hydrogels containing alginate (Alg) and gelatin (Gel). Then, we test the printability and durability of bioprinted SF-containing hydrogels. Finally, we evaluate whether the addition of SF controls cell viability and function of CSs in Alg–Gel hydrogels. Our findings show that the addition of 1% (w/v) SF to Alg–Gel hydrogels makes them more elastic without affecting cell viability. However, fractional shortening (FS%) of CSs in SF–Alg–Gel hydrogels increases without affecting their contraction frequency, suggesting an improvement in contractile function in the 3D cultures. Altogether, our findings support a promising pathway to bioengineer bioinks containing SF for cardiac applications, with the ability to control mechanical and cellular features in cardiac bioinks.
Villani, M, Quiroz, M, Kohn, R & Salomone, R 2024, 'Spectral Subsampling MCMC for Stationary Multivariate Time Series with Applications to Vector ARTFIMA Processes', Econometrics and Statistics, vol. 32, pp. 98-121.
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Vo, PHN, Danaee, S, Hai, HTN, Huy, LN, Nguyen, TAH, Nguyen, HTM, Kuzhiumparambil, U, Kim, M, Nghiem, LD & Ralph, PJ 2024, 'Biomining for sustainable recovery of rare earth elements from mining waste: A comprehensive review', Science of The Total Environment, vol. 908, pp. 168210-168210.
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Vo, PHN, Kuzhiumparambil, U, Kim, M, Hinkley, C, Pernice, M, Nghiem, LD & Ralph, PJ 2024, 'Biomining using microalgae to recover rare earth elements (REEs) from bauxite', Bioresource Technology, vol. 406, pp. 131077-131077.
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Vo, PHN, Ky Le, G, Huy, LN, Zheng, L, Chaiwong, C, Nguyen, NN, Nguyen, HTM, Ralph, PJ, Kuzhiumparambil, U, Danaee, S, Toft, S, Madsen, C, Kim, M, Fenstermacher, J, Hai, HTN, Duan, H & Tscharke, B 2024, 'Occurrence, spatiotemporal trends, fate, and treatment technologies for microplastics and organic contaminants in biosolids: A review', Journal of Hazardous Materials, vol. 466, pp. 133471-133471.
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Vo, PHN, Nguyen, TTP, Nguyen, HTM, Baulch, J, Dong, S, Nguyen, CV, Thai, PK & Nguyen, AV 2024, 'PFAS removal from landfill leachate by ozone foam fractionation: System optimization and adsorption quantification', Water Research, vol. 253, pp. 121300-121300.
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Vo, TP, Danaee, S, Chaiwong, C, Pham, BT, Poddar, N, Kim, M, Kuzhiumparambil, U, Songsomboon, C, Pernice, M, Ngo, HH, Ralph, PJ & Vo, PHN 2024, 'Microalgae-bacteria consortia for organic pollutants remediation from wastewater: A critical review', Journal of Environmental Chemical Engineering, vol. 12, no. 6, pp. 114213-114213.
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Vollset, SE, Ababneh, HS, Abate, YH, Abbafati, C, Abbasgholizadeh, R, Abbasian, M, Abbastabar, H, Abd Al Magied, AHA, Abd ElHafeez, S, Abdelkader, A, Abdelmasseh, M, Abd-Elsalam, S, Abdi, P, Abdollahi, M, Abdoun, M, Abdullahi, A, Abebe, M, Abiodun, O, Aboagye, RG, Abolhassani, H, Abouzid, M, Aboye, GB, Abreu, LG, Absalan, A, Abualruz, H, Abubakar, B, Abukhadijah, HJJ, Addolorato, G, Adekanmbi, V, Adetunji, CO, Adetunji, JB, Adeyeoluwa, TE, Adha, R, Adhikary, RK, Adnani, QES, Adzigbli, LA, Afrashteh, F, Afzal, MS, Afzal, S, Agbozo, F, Agodi, A, Agrawal, A, Agyemang-Duah, W, Ahinkorah, BO, Ahlstrom, AJ, Ahmad, A, Ahmad, F, Ahmad, MM, Ahmad, S, Ahmad, S, Ahmed, A, Ahmed, A, Ahmed, H, Ahmed, S, Ahmed, SA, Akinosoglou, K, Akkaif, MA, Akrami, AE, Akter, E, Al Awaidy, S, Al Hasan, SM, Al Mosa, AS, Al Ta'ani, O, Al Zaabi, OAM, Alahdab, F, Alajlani, MM, Al-Ajlouni, Y, Alalalmeh, SO, Al-Aly, Z, Alam, K, Alam, N, Alam, T, Alam, Z, Al-amer, RM, Alanezi, FM, Alanzi, TM, Albakri, A, Aldhaleei, WA, Aldridge, RW, Alemohammad, SY, Alemu, YM, Al-Gheethi, AAS, Al-Hanawi, MK, Ali, A, Ali, A, Ali, I, Ali, MU, Ali, R, Ali, SSS, Ali, VE, Ali, W, Al-Ibraheem, A, Alicandro, G, Alif, SM, Aljunid, SM, Alla, F, Almazan, JU, Al-Mekhlafi, HM, Alqutaibi, AY, Alrawashdeh, A, Alrousan, SM, Al-Sabah, SK, Alsabri, MA, Altaany, Z, Al-Tammemi, AB, Al-Tawfiq, JA, Altirkawi, KA, Aluh, DO, Alvis-Guzman, N, Al-Wardat, MS, Al-Worafi, YM, Aly, H, Alyahya, MS, Alzoubi, KH, Al-Zyoud, W, Amani, R, Ameyaw, EK, Amin, TT, Amindarolzarbi, A, Amiri, S, Amirzade-Iranaq, MH, Amu, H, Amugsi, DA, Ancuceanu, R, Anderlini, D, Anderson, DB, Andrade, PP, Andrei, CL, Andrei, T, Andrews, EA, Anil, A, Anil, S, Anoushiravani, A, Antony, CM, Antriyandarti, E, Anuoluwa, BS, Anvari, S, Anyasodor, AE, Appiah, F, Aquilano, M, Arab, JP, Arabloo, J, Arafa, EA, Arafat, M, Aravkin, AY, Ardekani, A, Areda, D, Aregawi, BB, Aremu, A, Ariffin, H, Arkew, M, Armani, K, Artamonov, AA, Arumugam, A, Asghari-Jafarabadi, M, Ashbaugh, C, Astell-Burt, T, Athari, SS, Atorkey, P, Atout, MMW, Aujayeb, A, Ausloos, M, Awad, H, Awotidebe, AW, Ayatollahi, H, Ayuso-Mateos, JL, Azadnajafabad, S, Azeez, FK, Azevedo, RMS, Badar, M, Baghdadi, S, Bagheri, M, Bagheri, N, Bai, R, Baker, JL, Bako, AT, Balakrishnan, S, Balcha, WF, Baltatu, OC, Barchitta, M, Bardideh, E, Barker-Collo, SL, Bärnighausen, TW, Barqawi, HJ & et al. 2024, 'Burden of disease scenarios for 204 countries and territories, 2022–2050: a forecasting analysis for the Global Burden of Disease Study 2021', The Lancet, vol. 403, no. 10440, pp. 2204-2256.
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Voolstra, CR, Raina, J-B, Dörr, M, Cárdenas, A, Pogoreutz, C, Silveira, CB, Mohamed, AR, Bourne, DG, Luo, H, Amin, SA & Peixoto, RS 2024, 'The coral microbiome in sickness, in health and in a changing world', Nature Reviews Microbiology, vol. 22, no. 8, pp. 460-475.
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Wajahat, M, Kouzani, AZ, Khoo, SY & Mahmud, MAP 2024, 'Development of Triboelectric Nanogenerators Using Novel 3D Printed Polymer Materials', Advanced Engineering Materials, vol. 26, no. 3.
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Triboelectric nanogenerators (TENGs) are becoming attractive devices for harvesting mechanical energy. 3D printing (3DP) is a newly reported technique for the development of this device. This technique is not fully explored for the fabrication of triboelectric materials and compatible printing processes. Herein, three main 3DP techniques including powder‐based multijet fusion, resin‐based polyjet fusion, and filament‐based fused deposition modeling are utilized to investigate new sets of 3DP triboelectric materials. Mechanical to electrical conversion efficiency of 3D printed and commercially available negative and positive triboelectric materials are compared and investigated. Polyamide ‐12 (PA12), Veroclear, acrylonitrile‐styrene‐acrylate (ASA), copper‐coated polylactic acid (Cu‐PLA), polycarbonate (PC), and polyethylene terephthalate glycol (PETG) are fabricated using compatible 3D printing techniques. 3D‐printed PA12 is considered as a reference positive triboelectric layer. Meanwhile, 3D‐printed Veroclear, ASA, Cu‐PLA, PC, PETG, and commercial materials like Teflon sheets, PA6,6 conductive sheets, indium tin oxide‐coated polyethylene terephthalate, conductive‐nylon sheets, and PVDF membrane are selected as negative triboelectric materials. The maximum AC voltage of 80 V and maximum instantaneous current of 0.9 μA are produced by pairing 3DP‐PA12 and 3DP‐Veroclear under open circuit condition. This AC output is further converted to DC output using brdige rectifier circuitry to efficiently charge up the capacitor and glow series of 16 LEDs.
Wajahat, M, Kouzani, AZ, Khoo, SY & Mahmud, MAP 2024, 'Output Enhancement of a 3D‐Printed Triboelectric Nanogenerator Using Laser Surface 3D Patterning', Advanced Engineering Materials, vol. 26, no. 14.
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This study investigates the performance of contact separation and sliding modes of triboelectric Nanogenerators (TENGs) using COMSOL Multiphysics simulation environment. The output performance of a plain surface TENG is compared with square, rectangular, and pyramid‐patterned TENGs. The pyramid pattern emerges as the most efficient geometry, demonstrating a solid output of 95.8 V (Voc) and 0.99 μA (Isc). Advanced 3D printing techniques (3DP) including powder‐based multijet fusion and resin‐based polyjet fusion are utilized to print polyamide 12 (PA12) and VeroClear, respectively. The laser surface patterning technique is used to make precise micropatterns on the surfaces of the VeroClear and PA12 layers, resulting in a consistent and effective surface morphology that enhances the surface area of triboelectric layers, and outperforms traditional approaches of patterning in consistency and efficacy. The validation of simulation results is made where the pyramid pattern is emerged as the most efficient geometry experimentally. Performance is maintained with minimal degradation after 102 cycles, and a 22 μF–63 V capacitor is successfully used to store the generated charge. This study not only sets the path for pre‐experimental analysis using simulation environment but also provides a clear demonstration of advanced manufacturing techniques for printing and patterning 3D‐printed triboelectric materials.
Wang, J, Dai, S, Xiang, N, Zhang, L, Zhong, W, Shao, P & Feng, S 2024, 'Cell-Based Meat Scaffold Based on a 3D-Printed Starch-Based Gel', Journal of Agricultural and Food Chemistry, vol. 72, no. 34, pp. 19143-19154.
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Wang, J, Zhao, Y, Sun, B, Yang, Y, Wang, S, Feng, Z & Li, J 2024, 'The structure of anthocyanins and the copigmentation by common micromolecular copigments: A review', Food Research International, vol. 176, pp. 113837-113837.
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Wang, Q, Zhang, Y, Li, H, Ying, S, Ding, Z, Wang, Y, Fang, T, Wei, C, Ma, C, Sun, B, Liu, X & Tang, X 2024, 'Unlocking the potential of ionic liquid-functionalized aqueous electrolytes for aqueous ammonium-bromine/ion batteries', Energy Storage Materials, vol. 70, pp. 103553-103553.
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Wang, Y, Thaler, M, Salgado‐Benvindo, C, Ly, N, Leijs, AA, Ninaber, DK, Hansbro, PM, Boedijono, F, van Hemert, MJ, Hiemstra, PS, van der Does, AM & Faiz, A 2024, 'SARS‐CoV‐2‐infected human airway epithelial cell cultures uniquely lack interferon and immediate early gene responses caused by other coronaviruses', Clinical & Translational Immunology, vol. 13, no. 4.
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AbstractObjectivesSevere acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) is a member of a class of highly pathogenic coronaviruses. The large family of coronaviruses, however, also includes members that cause only mild symptoms, like human coronavirus‐229E (HCoV‐229E) or OC43 (HCoV‐OC43). Unravelling how molecular (and cellular) pathophysiology differs between highly and low pathogenic coronaviruses is important for the development of therapeutic strategies.MethodsHere, we analysed the transcriptome of primary human bronchial epithelial cells (PBEC), differentiated at the air–liquid interface (ALI) after infection with SARS‐CoV‐2, SARS‐CoV, Middle East Respiratory Syndrome (MERS)‐CoV and HCoV‐229E using bulk RNA sequencing.ResultsALI‐PBEC were efficiently infected by all viruses, and SARS‐CoV, MERS‐CoV and HCoV‐229E infection resulted in a largely similar transcriptional response. The response to SARS‐CoV‐2 infection differed markedly as it uniquely lacked the increase in expression of immediate early genes, including FOS, FOSB and NR4A1 that was observed with all other coronaviruses. This finding was further confirmed in publicly available experimental and clinical datasets. Interfering with NR4A1 signalling in Calu‐3 lung epithelial cells resulted in a 100‐fold reduction in extracellular RNA copies of SARS‐CoV‐2 and MERS‐CoV, suggesting an involvement in virus replication. Furthermore, a lack in induction of interferon‐related gene expression characterised the main difference between the highly pathogenic coronaviruses and low pathogenic viruses HCoV‐229E and HCoV‐OC43.ConclusionOur results demonstrate a previousl...
Wang, Y, Weng, S, Tang, Y, Lin, S, Liu, X, Zhang, W, Liu, G, Pandi, B, Wu, Y, Ma, L & Wang, L 2024, 'A transmembrane scaffold from CD20 helps recombinant expression of a chimeric claudin 18.2 in an in vitro coupled transcription and translation system', Protein Expression and Purification, vol. 215, pp. 106392-106392.
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Wang, Y, Yang, S, Han, B, Du, X, Sun, H, Du, Y, Liu, Y, Lu, P, Di, J, Luu, LDW, Lv, X, Hu, S, Wang, L & Jiang, R 2024, 'Single‐cell landscape revealed immune characteristics associated with disease phases in brucellosis patients', iMeta, vol. 3, no. 4.
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AbstractA comprehensive immune landscape for Brucella infection is crucial for developing new treatments for brucellosis. Here, we utilized single‐cell RNA sequencing (scRNA‐seq) of 290,369 cells from 35 individuals, including 29 brucellosis patients from acute (n = 10), sub‐acute (n = 9), and chronic (n = 10) phases as well as six healthy donors. Enzyme‐linked immunosorbent assays were applied for validation within this cohort. Brucella infection caused a significant change in the composition of peripheral immune cells and inflammation was a key feature of brucellosis. Acute patients are characterized by potential cytokine storms resulting from systemic upregulation of S100A8/A9, primarily due to classical monocytes. Cytokine storm may be mediated by activating S100A8/A9‐TLR4‐MyD88 signaling pathway. Moreover, monocytic myeloid‐derived suppressor cells were the probable contributors to immune paralysis in acute patients. Chronic patients are characterized by a dysregulated Th1 response, marked by reduced expression of IFN‐γ and Th1 signatures as well as a high exhausted state. Additionally, Brucella infection can suppress apoptosis in myeloid cells (e.g., mDCs, classical monocytes), inhibit antigen presentation in professional antigen‐presenting cells (APCs; e.g., mDC) and nonprofessional APCs (e.g., monocytes), and induce exhaustion in CD8+ T/NK cells, potentially resulting in the establishment of chronic infection. Overall, our study systemically deciphered the coordinated immune responses of Brucella at different phases of the infection, which facilitated a full understanding of the immunopathogenesis of brucellosis and may aid the development of new effecti...
Wang, Y, Yang, X, Meng, Y, Wen, Z, Han, R, Hu, X, Sun, B, Kang, F, Li, B, Zhou, D, Wang, C & Wang, G 2024, 'Fluorine Chemistry in Rechargeable Batteries: Challenges, Progress, and Perspectives', Chemical Reviews, vol. 124, no. 6, pp. 3494-3589.
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Wang, Z, Shi, W, Carroll, RJ & Chatterjee, N 2024, 'Joint modeling of gene-environment correlations and interactions using polygenic risk scores in case-control studies', American Journal of Epidemiology, vol. 193, no. 10, pp. 1451-1459.
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Abstract Polygenic risk scores (PRSs) are rapidly emerging as a way to measure disease risk by aggregating multiple genetic variants. Understanding the interplay of the PRS with environmental factors is critical for interpreting and applying PRSs in a wide variety of settings. We develop an efficient method for simultaneously modeling gene-environment correlations and interactions using the PRS in case-control studies. We use a logistic-normal regression modeling framework to specify the disease risk and PRS distribution in the underlying population and propose joint inference across the 2 models using the retrospective likelihood of the case-control data. Extensive simulation studies demonstrate the flexibility of the method in trading-off bias and efficiency for the estimation of various model parameters compared with standard logistic regression or a case-only analysis for gene-environment interactions, or a control-only analysis, for gene-environment correlations. Finally, using simulated case-control data sets within the UK Biobank study, we demonstrate the power of our method for its ability to recover results from the full prospective cohort for the detection of an interaction between long-term oral contraceptive use and the PRS on the risk of breast cancer. This method is computationally efficient and implemented in a user-friendly R package.
Ward, J 2024, 'The operationalization of a multifaceted, multijurisdictional, multiagency and multidisciplinary capability for unidentified and missing persons investigations in Australia', Australian Journal of Forensic Sciences, vol. 56, no. sup1, pp. 65-70.
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Ward, J, Coakley, L, Grisedale, K, Seddon, S, Spiden, M, Watson, JL & McNevin, D 2024, 'Operationalization of the National DNA Program for Unidentified and Missing Persons' Forensic Investigative Genetic Genealogy Capability for Human Remains Identification in Australia', Forensic Genomics, vol. 4, no. 1, pp. 32-40.
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Waszczuk, JR, Peacock, L, Chadwick, S, Maynard, P, Raymond, J & Roux, C 2024, 'Misidentifications of alphanumeric characters in serial number restorations', Australian Journal of Forensic Sciences, vol. 56, no. 2, pp. 168-188.
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Chemical etching has long been established as a reliable means of recovering defaced characters such as serial numbers. Although successful restorations can present clearly defined characters, a preliminary assessment of proficiency test results shows varied participant interpretations of samples marked with the same characters. Thus, a study was completed to determine if specific alphanumeric characters are more likely to be misidentified, comprising a practical exercise and analysis of 16 compiled proficiency test results. The practical exercise involved 64 steel plates stamped with six randomized characters that were removed and chemically restored. Participants individually assessed the plates and provided their interpretations. A total of 39 participants of various backgrounds and experience in serial number restorations were used in this study. After comparing participant interpretations with the ground truth, characters more prone to be misidentified were determined. The proficiency test results showed that the most frequently misidentified characters were the letters B and N, among a limited set. Whilst the practical assessment found a notable increase in misidentifications for the letters G, Q and S. Interestingly, none of these characters were used in the proficiency tests. It is hoped that the results of this study raise awareness for forensic examiners undertaking restorations.
Waszczuk, JR, Raymond, J, Maynard, P, Roux, C & Chadwick, S 2024, 'The reliability of character recognition: An Australian & New Zealand expert-novice comparison study in the interpretation of chemically recovered serial numbers', Forensic Science International, vol. 361, pp. 112127-112127.
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Watherston, J & McNevin, D 2024, 'Skull and long bones – Forensic DNA techniques for historic shipwreck human remains', Australian Journal of Forensic Sciences, vol. 56, no. 4, pp. 367-391.
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Human remains have been recovered from a number of historic shipwrecks and their associated sites, often hundreds of years post-mortem. While remains of victims who have fled following wrecking can be subject to a range of environmental exposures, human remains in marine environments are subject to unique decomposition processes, faunal predation and impacts on DNA. Researchers in museums and academic institutions holding historic shipwreck remains have applied a plethora of scientific testing methods to extract information from artefacts and shipwreck remains. Specialist forensic DNA techniques, often adapted from ancient and archaeological DNA methods, are designed to maximize DNA recovery, and advances in technology and forensic biology have increased options for genotyping compromised human skeletal samples. A vast array of new genetic markers can now be targeted for interrogation to reveal externally visible characteristics, biogeographical ancestry or extended genetic relatives of victims. Some of these techniques have already been applied to historic shipwreck remains. This paper reviews current and emerging forensic DNA techniques available for recovering and revealing genetic information from historic shipwreck remains. It aims to direct investigators conducting genetic testing on historic shipwreck human remains to forensic DNA techniques as a possible approach for yielding further invaluable information.
Watson, J, McNevin, D, Grisedale, K, Spiden, M, Seddon, S & Ward, J 2024, 'Operationalisation of the ForenSeq® Kintelligence Kit for Australian unidentified and missing persons casework', Forensic Science International: Genetics, vol. 68, pp. 102972-102972.
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Single nucleotide polymorphism (SNP) genotyping technologies can generate investigative leads for human remains identification, including estimation of biological sex, biogeographical ancestry (BGA), externally visible characteristics (EVCs), identity, uniparental lineage and extended kinship. The ForenSeq® Kintelligence Kit provides forensic laboratories with the ability to apply this suite of genetic tools to forensic samples using one panel targeting 10,230 SNPs (including 56 ancestry-informative, 24 phenotype-informative, 94 identity-informative, 106 X chromosome, 85 Y chromosome and 9867 kinship-informative SNPs) sequenced on the MiSeq FGx® Sequencing System. The ForenSeq® Kintelligence Kit has been internally validated, optimised and operationalised by the Australian Federal Police National DNA Program for Unidentified and Missing Persons (AFP Program) for coronial casework. The internal validation was conducted according to the Scientific Working Group on DNA Analysis Methods guidelines (excluding mixture analysis), focussing on sample types typically encountered in human remains identification casework, such as bones, teeth, nail, blood and hair. The workflow was optimised for a high throughput library preparation and sequencing workflow, and additional analytical thresholds were developed to improve genotyping accuracy for low DNA input samples. Additionally, the genetic intelligence generated from the kit was compared to the self-declared biological sex, EVCs and BGA of the DNA donors to assess concordance. The kit was able to produce high quality SNP profiles from 1.0 ng down to 0.1 ng of DNA, with high repeatability and reproducibility, and minimal background noise. The prediction accuracy for biological sex (95%), hair colour (58%), eye colour (74%) and BGA inferences (consistent: 74%; partially consistent: 10%; inconclusive: 16%) was determined based on self-declared data. Additionally, SNP profiles from a volunteer family group of ten rel...
Watson, JL, McNevin, D & Ward, J 2024, 'Genetic Kinship Testing Techniques for Human Remains Identification and Missing Persons Investigations', Forensic Genomics, vol. 4, no. 1, pp. 4-23.
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Webb, JR, Andersson, P, Sim, E, Zahedi, A, Donald, A, Hoang, T, Watt, AE, Agius, JE, Donato, CM, Cummins, ML, Zulfiqar, T, Nghiem, S, Lin, C, Menouhos, D, Leong, LEX, Baird, R, Kennedy, K, Cooley, L, Speers, D, Lim, CK, de Ligt, J, Ferdinand, A, Glass, K, Kirk, MD, Djordjevic, SP, Sloggett, C, Horan, K, Seemann, T, Sintchenko, V, Jennison, AV & Howden, BP 2024, 'Implementing a national programme of pathogen genomics for public health: the Australian Pathogen Genomics Program (AusPathoGen)', The Lancet Microbe, pp. 100969-100969.
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Weyermann, C, Willis, S, Margot, P & Roux, C 2024, 'Response to the letter to the Editor commenting on “Towards more relevance in forensic science research and development” by Weyermann et al.', Forensic Science International, vol. 355, pp. 111928-111928.
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Wijayatunga, P, Bandyopadhyay, PS & Woodcock, S 2024, 'Editorial: Probability and its paradoxes for critical thinking', Frontiers in Education, vol. 9, pp. 1-3.
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Williams, NLR, Siboni, N, Potts, J, Scanes, P, Johnson, C, James, M, McCann, V, Reun, NL, King, WL & Seymour, JR 2024, 'Faecal contamination determines bacterial assemblages over natural environmental parameters within intermittently opened and closed lagoons (ICOLLs) during high rainfall', Water Research, pp. 122670-122670.
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Windhagauer, M, Doblin, MA, Signal, B, Kuzhiumparambil, U, Fabris, M & Abbriano, RM 2024, 'Metabolic response to a heterologous poly-3-hydroxybutyrate (PHB) pathway in Phaeodactylum tricornutum', Applied Microbiology and Biotechnology, vol. 108, no. 1, pp. 1-16.
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Wong, SL, Gan, JS, De Rubis, G, Paudel, KR, Yeung, S, Chellappan, DK, Keng, PS & Dua, K 2024, 'Innovative phytoceutical-based drug delivery in the management of pulmonary fibrosis: A roadmap towards inhaled therapeutics', Journal of Drug Delivery Science and Technology, vol. 99, pp. 105942-105942.
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Wong‐Bajracharya, J, Webster, J, Rigano, LA, Kant, P, Englezou, A, Snijders, F, Roach, R, Wang, C, Kehoe, M, Mann, R, Constable, FE & Chapman, TA 2024, 'All‐in‐one Xylella detection and identification: A nanopore sequencing‐compatible conventional PCR', Plant Pathology, vol. 73, no. 5, pp. 1072-1089.
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AbstractXylella fastidiosa is a plant‐pathogenic bacterium that poses a serious threat to the production of economically important plant species including grapes, almonds, olives and a broad range of amenity plants, causing significant economic losses worldwide. While multiple molecular detection assays have been developed for X. fastidiosa, there is a lack of molecular tools available for detection and differentiation of the closely related pear pathogen, Xylella taiwanensis. In this study, we present a novel conventional PCR assay with primers that can amplify both Xylella species. The amplified product could be sequenced and used for discrimination between the two species and the subspecies within the fastidiosa species. This PCR assay was designed using a genome‐informed approach to target the ComEC/Rec2 gene of both Xylella species, ensuring a higher specificity than other previously developed PCR assays. A test performance study across five national plant diagnostic laboratories in Australia and New Zealand demonstrated this assay's high sensitivity and specificity to all known species and subspecies within the Xylella genus. This PCR assay can be used for Xylella identification at the species and subspecies level and is compatible with Sanger sequencing and nanopore sequencing for rapid turnaround time. The newly developed conventional PCR assay presented here offers rapid detection and accurate identification of both Xylella species from plant, insect vector or bacterial samples, enabling timely implementation of biosecurity measures or disease management responses.
Woodcock, S & Falletta, J 2024, 'A numerical evaluation of the Finite Monkeys Theorem', Franklin Open, pp. 100171-100171.
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Wright, K, Han, DJY, Song, R, de Silva, K, Plain, KM, Purdie, AC, Shepherd, A, Chin, M, Hortle, E, Wong, JJ-L, Britton, WJ & Oehlers, SH 2024, 'Zebrafishtsc1andcxcl12aincrease susceptibility to mycobacterial infection', Life Science Alliance, vol. 7, no. 4, pp. e202302523-e202302523.
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Regulation of host miRNA expression is a contested node that controls the host immune response to mycobacterial infection. The host must counter subversive efforts of pathogenic mycobacteria to launch a protective immune response. Here, we examine the role of miR-126 in the zebrafish–Mycobacterium marinuminfection model and identify a protective role for infection-induced miR-126 through multiple effector pathways. We identified a putative link between miR-126 and thetsc1aandcxcl12a/ccl2/ccr2signalling axes resulting in the suppression of non-tnfaexpressing macrophage accumulation at earlyM. marinumgranulomas. Mechanistically, we found a detrimental effect oftsc1aexpression that renders zebrafish embryos susceptible to higher bacterial burden and increased cell death via mTOR inhibition. We found that macrophage recruitment driven by thecxcl12a/ccl2/ccr2signalling axis was at the expense of the recruitment of classically activatedtnfa-expressing macrophages and increased cell death around granulomas. Together, our results delineate putative pathways by which infection-induced miR-126 may shape an effective immune response toM. marinuminfection in zebrafish embryos.
Wu, W, Pang, CNI, Mediati, DG & Tree, JJ 2024, 'The functional small RNA interactome reveals targets for the vancomycin-responsive sRNA RsaOI in vancomycin-tolerant Staphylococcus aureus', mSystems, vol. 9, no. 4.
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ABSTRACT Small RNAs have been found to control a broad range of bacterial phenotypes including tolerance to antibiotics. Vancomycin tolerance in multidrug resistance Staphylococcus aureus is correlated with dysregulation of small RNAs although their contribution to antibiotic tolerance is poorly understood. RNA-RNA interactome profiling techniques are expanding our understanding of sRNA-mRNA interactions in bacteria; however, determining the function of these interactions for hundreds of sRNA-mRNA pairs is a major challenge. At steady-state, protein and mRNA abundances are often highly correlated and lower than expected protein abundance may indicate translational repression of an mRNA. To identify sRNA-mRNA interactions that regulate mRNA translation, we examined the correlation between gene transcript abundance, ribosome occupancy, and protein levels. We used the machine learning technique self-organizing maps (SOMs) to cluster genes with similar transcription and translation patterns and identified a cluster of mRNAs that appeared to be post-transcriptionally repressed. By integrating our clustering with sRNA-mRNA interactome data generated in vancomycin-tolerant S. aureus by RNase III-CLASH, we identified sRNAs that may be mediating translational repression. We have confirmed sRNA-dependant post-transcriptional repression of several mRNAs in this cluster. Two of these interactions are mediated by RsaOI, a sRNA that is highly upregulated by vancomycin. We demonstrate the regulation of HPr and the cell-wall autolysin Atl. These findings suggest that RsaOI coordinates carbon metabolism and cell wall turnover during vancomycin treatment. IMPORTANCE
Wyrsch, ER, Hoye, BJ, Sanderson-Smith, M, Gorman, J, Maute, K, Cummins, ML, Jarocki, VM, Marenda, MS, Dolejska, M & Djordjevic, SP 2024, 'The faecal microbiome of the Australian silver gull contains phylogenetically diverse ExPEC, aEPEC and Escherichia coli carrying the transmissible locus of stress tolerance', Science of The Total Environment, vol. 919, pp. 170815-170815.
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Xiang, M, Jiang, Y, Zhou, J, Bao, G, Luo, X, Zhang, L, Jin, D, Xian, Y & Zhang, C 2024, 'NIR light-controlled DNA nanodevice for amplified mRNA imaging and precise gene therapy', Nano Today, vol. 54, pp. 102110-102110.
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Xiao, J, Xiao, Y, Wang, S, Huang, Z, Li, J, Gong, C, Zhang, G, Sun, B, Gao, H, Li, H, Guo, X, Wang, Y, Liu, H & Wang, G 2024, 'Surface engineering of P2-type cathode material targeting long-cycling and high-rate sodium-ion batteries', Journal of Energy Chemistry, vol. 97, pp. 444-452.
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Xiao, Y, Xiao, J, Zhao, H, Li, J, Zhang, G, Zhang, D, Guo, X, Gao, H, Wang, Y, Chen, J, Wang, G & Liu, H 2024, 'Prussian Blue Analogues for Sodium‐Ion Battery Cathodes: A Review of Mechanistic Insights, Current Challenges, and Future Pathways', Small, vol. 20, no. 35.
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AbstractPrussian blue analogues (PBAs) have emerged as highly promising cathode materials for sodium‐ion batteries (SIBs) due to their affordability, facile synthesis, porous framework, and high theoretical capacity. Despite their considerable potential, practical applications of PBAs face significant challenges that limit their performance. This review offers a comprehensive retrospective analysis of PBAs' development history as cathode materials, delving into their reaction mechanisms, including charge compensation and ion diffusion mechanisms. Furthermore, to overcome these challenges, a range of improvement strategies are proposed, encompassing modifications in synthesis techniques and enhancements in structural stability. Finally, the commercial viability of PBAs is examined, alongside discussions on advanced synthesis methods and existing concerns regarding cost and safety, aiming to foster ongoing advancements of PBAs for practical SIBs.
Xu, J, Han, P, Jin, Y, Lu, H, Sun, B, Gao, B, He, T, Xu, X, Pinna, N & Wang, G 2024, 'Hybrid Molecular Sieve-Based Interfacial Layer with Physical Confinement and Desolvation Effect for Dendrite-free Zinc Metal Anodes', ACS Nano, vol. 18, no. 28, pp. 18592-18603.
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Xu, J, Li, H, Jin, Y, Zhou, D, Sun, B, Armand, M & Wang, G 2024, 'Understanding the Electrical Mechanisms in Aqueous Zinc Metal Batteries: From Electrostatic Interactions to Electric Field Regulation', Advanced Materials, vol. 36, no. 3, p. e2309726.
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AbstractAqueous Zn metal batteries are considered as competitive candidates for next‐generation energy storage systems due to their excellent safety, low cost, and environmental friendliness. However, the inevitable dendrite growth, severe hydrogen evolution, surface passivation, and sluggish reaction kinetics of Zn metal anodes hinder the practical application of Zn metal batteries. Detailed summaries and prospects have been reported focusing on the research progress and challenges of Zn metal anodes, including electrolyte engineering, electrode structure design, and surface modification. However, the essential electrical mechanisms that significantly influence Zn2+ ions migration and deposition behaviors have not been reviewed yet. Herein, in this review, the regulation mechanisms of electrical‐related electrostatic repulsive/attractive interactions on Zn2+ ions migration, desolvation, and deposition behaviors are systematically discussed. Meanwhile, electric field regulation strategies to promote the Zn2+ ions diffusion and uniform Zn deposition are comprehensively reviewed, including enhancing and homogenizing electric field intensity inside the batteries and adding external magnetic/pressure/thermal field to couple with the electric field. Finally, future perspectives on the research directions of the electrical‐related strategies for building better Zn metal batteries in practical applications are offered.
Xu, J, Qiu, Y, Yang, J, Li, H, Han, P, Jin, Y, Liu, H, Sun, B & Wang, G 2024, 'Review of Separator Modification Strategies: Targeting Undesired Anion Transport in Room Temperature Sodium–Sulfur/Selenium/Iodine Batteries', Advanced Functional Materials, vol. 34, no. 2.
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AbstractRechargeable sodium–sulfur/selenium/iodine (Na–S/Se/I2) batteries are regarded as promising candidates for large‐scale energy storage systems, with the advantages of high energy density, low cost, and environmental friendliness. However, the electrochemical performances of Na–S/Se/I2 batteries are still restricted by several inherent issues, including the “shuttle effect” of polysulfides/polyselenides/polyiodides (PSs/PSes/PIs), sluggish kinetics of the conversion reactions at the cathodes, and Na dendrite growth at the anodes. Among these challenges, uncontrolled “shuttle effect” of PSs/PSes/PIs is a major contributing factor for the irreversible loss of active cathode materials and severe side reactions on Na metal anodes, leading to rapid failure of the batteries. Separator modification has been demonstrated to be an effective strategy to suppress the shuttling of PSs/PSes/PIs. Herein, the latest achievement in modifying separators for high‐performance Na–S/Se/I2 batteries is comprehensively reviewed. The reaction mechanisms of each battery system are first discussed. Then, strategies of separator modification based on the different functions for regulating the transportation of PSs/PSes/PIs are summarized, including applying electrostatic repulsive interaction, introducing conductive layers, improving sieving effects, enhancing chemisorption capability, and adding efficient electrocatalysts. Finally, future perspectives on the practical application of modified separators in high‐energy rechargeable batteries are provided.
Xu, J, Yang, J, Qiu, Y, Jin, Y, Wang, T, Sun, B & Wang, G 2024, 'Achieving high-performance sodium metal anodes: From structural design to reaction kinetic improvement', Nano Research, vol. 17, no. 3, pp. 1288-1312.
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AbstractSodium metal is one of the ideal anodes for high-performance rechargeable batteries because of its high specific capacity (~ 1166 mAh·g−1), low reduction potential (−2.71 V compared to standard hydrogen electrodes), and low cost. However, the unstable solid electrolyte interphase, uncontrolled dendrite growth, and inevitable volume expansion hinder the practical application of sodium metal anodes. At present, many strategies have been developed to achieve stable sodium metal anodes. Here, we systematically summarize the latest strategies adopted in interface engineering, current collector design, and the emerging methods to improve the reaction kinetics of sodium deposition processes. First, the strategies of constructing protective layers are reviewed, including inorganic, organic, and mixed protective layers through electrolyte additives or pretreatments. Then, the classification of metal-based, carbon-based, and composite porous frames is discussed, including their function in reducing local deposition current density and the effect of introducing sodiophilic sites. Third, the recent progress of alloys, nanoparticles, and single atoms in improving Na deposition kinetics is systematically reviewed. Finally, the future research direction and the prospect of high-performance sodium metal batteries are proposed.
Xu, X, Wang, W, Qiao, L, Fu, Y, Ge, X, Zhao, K, Zhanghao, K, Guan, M, Chen, X, Li, M, Jin, D & Xi, P 2024, 'Ultra-high spatio-temporal resolution imaging with parallel acquisition-readout structured illumination microscopy (PAR-SIM)', Light: Science & Applications, vol. 13, no. 1, p. 125.
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AbstractStructured illumination microscopy (SIM) has emerged as a promising super-resolution fluorescence imaging technique, offering diverse configurations and computational strategies to mitigate phototoxicity during real-time imaging of biological specimens. Traditional efforts to enhance system frame rates have concentrated on processing algorithms, like rolling reconstruction or reduced frame reconstruction, or on investments in costly sCMOS cameras with accelerated row readout rates. In this article, we introduce an approach to elevate SIM frame rates and region of interest (ROI) coverage at the hardware level, without necessitating an upsurge in camera expenses or intricate algorithms. Here, parallel acquisition-readout SIM (PAR-SIM) achieves the highest imaging speed for fluorescence imaging at currently available detector sensitivity. By using the full frame-width of the detector through synchronizing the pattern generation and image exposure-readout process, we have achieved a fundamentally stupendous information spatial-temporal flux of 132.9 MPixels · s−1, 9.6-fold that of the latest techniques, with the lowest SNR of −2.11 dB and 100 nm resolution. PAR-SIM demonstrates its proficiency in successfully reconstructing diverse cellular organelles in dual excitations, even under conditions of low signal due to ultra-short exposure times. Notably, mitochondrial dynamic tubulation and ongoing membrane fusion processes have been captured in live COS-7 cell, recorded with PAR-SIM at an impressive 408 Hz. We posit that this novel parallel exposure-readout mode not only augments SIM pattern modulation for superior frame rates but also holds the potential to benefit other complex imaging systems with a strategic controlling approach.
Xue, J, Huete, A, Liu, Z, Wang, Y & Lu, X 2024, 'Estimation of global ecosystem isohydricity from solar-induced chlorophyll fluorescence and meteorological datasets', Remote Sensing of Environment, vol. 307, pp. 114168-114168.
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Yang, L, Bao, G, Yao, C, Diao, T, Su, Z, Liu, T, Li, G, Wang, G, Chen, X, Xu, X, Sun, B, Xu, X, He, B & Zheng, Y 2024, 'Mitigating adverse effects of Cu-containing intrauterine devices using a highly biocompatible Cu 5Fe alloy', Acta Biomaterialia.
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Yang, X, Fu, Z, Han, R, Lei, Y, Wang, S, Zhao, X, Meng, Y, Liu, H, Zhou, D, Aurbach, D & Wang, G 2024, 'Design of Solid Polycationic Electrolyte to Enable Durable Chloride‐Ion Batteries', Angewandte Chemie, vol. 136, no. 29.
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AbstractThe high energy density and cost‐effectiveness of chloride‐ion batteries (CIBs) make them promising alternatives to lithium‐ion batteries. However, the development of CIBs is greatly restricted by the lack of compatible electrolytes to support cost‐effective anodes. Herein, we present a rationally designed solid polycationic electrolyte (SPE) to enable room‐temperature chloride‐ion batteries utilizing aluminum (Al) metal as an anode. This SPE endows the CIB configuration with improved air stability and safety (i.e. free of flammability and liquid leakage). A high ionic conductivity (1.3×10−2 S cm−1 at 25 °C) has been achieved by the well‐tailored coordination structure of the SPE. Meanwhile, the solid polycationic electrolyte ensures stable electrodes|electrolyte interfaces, which effectively inhibit the growth of dendrites on the Al anodes and degradation of the FeOCl cathodes. The Al|SPE|FeOCl chloride‐ion batteries showcased a high discharge capacity around 250 mAh g−1 (based on the cathodes) and extended lifespan. Our electrolyte design opens a new avenue for developing low‐cost chloride‐ion batteries.
Yang, X, Fu, Z, Han, R, Lei, Y, Wang, S, Zhao, X, Meng, Y, Liu, H, Zhou, D, Aurbach, D & Wang, G 2024, 'Design of Solid Polycationic Electrolyte to Enable Durable Chloride‐Ion Batteries', Angewandte Chemie International Edition, vol. 63, no. 29.
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AbstractThe high energy density and cost‐effectiveness of chloride‐ion batteries (CIBs) make them promising alternatives to lithium‐ion batteries. However, the development of CIBs is greatly restricted by the lack of compatible electrolytes to support cost‐effective anodes. Herein, we present a rationally designed solid polycationic electrolyte (SPE) to enable room‐temperature chloride‐ion batteries utilizing aluminum (Al) metal as an anode. This SPE endows the CIB configuration with improved air stability and safety (i.e. free of flammability and liquid leakage). A high ionic conductivity (1.3×10−2 S cm−1 at 25 °C) has been achieved by the well‐tailored coordination structure of the SPE. Meanwhile, the solid polycationic electrolyte ensures stable electrodes|electrolyte interfaces, which effectively inhibit the growth of dendrites on the Al anodes and degradation of the FeOCl cathodes. The Al|SPE|FeOCl chloride‐ion batteries showcased a high discharge capacity around 250 mAh g−1 (based on the cathodes) and extended lifespan. Our electrolyte design opens a new avenue for developing low‐cost chloride‐ion batteries.
YANG, Z, WU, S, ZHANG, XUN, CHAO, MI, LIN, G, GUO, Z & JIN, D 2024, 'Binocular Vision Fusion Enhanced 3D NIR-II in vivo Imaging of Bone and Vessel Networks', Fundamental Research.
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Yeung, S, Paudel, KR, Rubis, GD, Williams, KA, Hansbro, PM & Dua, K 2024, 'Exploring the current advancements of quercetin nanoformulations alleviating respiratory diseases', Future Medicinal Chemistry, vol. 16, no. 10, pp. 925-928.
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Yin, M, Wadhwa, R, Marshall, JE, Gillis, CM, Kim, RY, Dua, K, Palsson-McDermott, EM, Fallon, PG, Hansbro, PM & O’Neill, LAJ 2024, '4-Octyl Itaconate Alleviates Airway Eosinophilic Inflammation by Suppressing Chemokines and Eosinophil Development', The Journal of Immunology, vol. 212, no. 1, pp. 13-23.
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Abstract 4-Octyl itaconate (4-OI) is a derivative of the Krebs cycle–derived metabolite itaconate and displays an array of antimicrobial and anti-inflammatory properties through modifying cysteine residues within protein targets. We have found that 4-OI significantly reduces the production of eosinophil-targeted chemokines in a variety of cell types, including M1 and M2 macrophages, Th2 cells, and A549 respiratory epithelial cells. Notably, the suppression of these chemokines in M1 macrophages was found to be NRF2-dependent. In addition, 4-OI can interfere with IL-5 signaling and directly affect eosinophil differentiation. In a model of eosinophilic airway inflammation in BALB/c mice, 4-OI alleviated airway resistance and reduced eosinophil recruitment to the lungs. Our findings suggest that itaconate derivatives could be promising therapeutic agents for the treatment of eosinophilic asthma.
York, E, McNaughton, DA, Gertner, DS, Gale, PA, Murray, M & Rawling, T 2024, 'Expanding the π‐system of Fatty Acid‐Anion Transporter Conjugates Modulates Their Mechanism of Proton Transport and Mitochondrial Uncoupling Activity', Chemistry – A European Journal, vol. 30, no. 46.
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AbstractMitochondrial uncoupling by small molecule protonophores is a promising strategy for developing novel anticancer agents. Recently, aryl urea substituted fatty acids (aryl ureas) were identified as a new class of protonophoric anticancer agents. To mediate proton transport these molecules self‐assemble into membrane‐permeable anionic dimers in which intermolecular hydrogen bonds between the carboxylate and aryl‐urea anion receptor delocalise the negative charge across the aromatic π‐system. In this work, we extend the aromatic π‐system by introducing a second phenyl substituent to the aryl urea scaffold and compare the proton transport mechanisms and mitochondrial uncoupling actions of these compounds to their monoaryl analogues. It was found that incorporation of meta‐linked phenyl substituents into the aryl urea scaffold enhanced proton transport in vesicles and demonstrated superior capacity to depolarise mitochondria, inhibit ATP production and reduce the viability of MDA‐MB‐231 breast cancer cells. In contrast, diphenyl ureas linked through a 1,4‐distribution across the phenyl ring displayed diminished proton transport activity, despite both diphenyl urea isomers possessing similar binding affinities for carboxylates. Mechanistic studies suggest that inclusion of a second aryl ring changes the proton transport mechanism, presumably due to steric factors that impose higher energy penalties for dimer formation.
Yu, J, Liu, X, Sun, B, Yu, Y, Wu, S & Li, Z 2024, 'Nonlinear dynamic response of touchdown zone for steel catenary riser under multiple internal solitary waves', Ocean Engineering, vol. 297, pp. 117141-117141.
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Yu, Y, Wei, M, Cui, Y, Sun, B, Yu, Z, Xu, Q & Wu, Y 2024, 'Reliability-based topology-topography optimization for ship bulkhead structures considering multi-failure modes', Ocean Engineering, vol. 293, pp. 116681-116681.
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Yuen, ZW-S, Shanmuganandam, S, Stanley, M, Jiang, S, Hein, N, Daniel, R, McNevin, D, Jack, C & Eyras, E 2024, 'Profiling age and body fluid DNA methylation markers using nanopore adaptive sampling', Forensic Science International: Genetics, vol. 71, pp. 103048-103048.
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Zambrano-Villacres, R, Frias-Toral, E, Maldonado-Ponce, E, Poveda-Loor, C, Leal, P, Velarde-Sotres, A, Leonardi, A, Trovato, B, Roggio, F, Castorina, A, Wenxin, X & Musumeci, G 2024, 'Exploring body composition and somatotype profiles among youth professional soccer players', Mediterranean Journal of Nutrition and Metabolism, vol. 17, no. 3, pp. 241-254.
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OBJECTIVE: This study aimed to analyze the body composition and somatotype of professional soccer players, investigating variations across categories and playing positions. METHODS: An observational, cross-sectional, and analytical study was conducted with 51 male professional soccer players in the U-19 and U-20 categories. Data about sex, age, height, and weight were collected between March and May 2023. Body composition analysis utilized the ISAK protocol for the restricted profile, while somatotype categorization employed the Heath and Carter formula. Statistical analysis was performed using IBM SPSS Statistics V.26, which involved the application of Mann-Whitney and Kruskal-Wallis tests to discern differences in body composition variables and proportionality based on categories and playing positions. The Dunn test further identified specific positions exhibiting significant differences. RESULTS: The study encompassed 51 players, highlighting meaningful differences in body composition. The average body mass in kg was 75.8 (±6.9) for U-20 players and 70.5 (±6.1) for U-19 players. The somatotype values were 2.6-4.6-2.3 for U-20 players and 2.5-4.3-2.8 for U-19 players, with a predominance of muscle mass in all categories, characterizing them as balanced mesomorphs. CONCLUSIONS: Body composition and somatotype findings underscore distinctions in body mass across categories and playing positions, with notably higher body mass and muscle mass predominance in elevated categories. However, the prevailing skeletal muscle development establishes a significant semblance with the recognized somatotype standard for soccer.
Zhang, D, Tong, J, Jing, N, Yang, Y, Luo, C, Lu, Y, Christakis, DA, Güthe, D, Hornig, M, Kelleher, KJ, Morse, KE, Rogerson, CM, Divers, J, Carroll, RJ, Forrest, CB & Chen, Y 2024, 'Learning competing risks across multiple hospitals: one-shot distributed algorithms', Journal of the American Medical Informatics Association, vol. 31, no. 5, pp. 1102-1112.
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Abstract Objectives To characterize the complex interplay between multiple clinical conditions in a time-to-event analysis framework using data from multiple hospitals, we developed two novel one-shot distributed algorithms for competing risk models (ODACoR). By applying our algorithms to the EHR data from eight national children’s hospitals, we quantified the impacts of a wide range of risk factors on the risk of post-acute sequelae of SARS-COV-2 (PASC) among children and adolescents. Materials and Methods Our ODACoR algorithms are effectively executed due to their devised simplicity and communication efficiency. We evaluated our algorithms via extensive simulation studies as applications to quantification of the impacts of risk factors for PASC among children and adolescents using data from eight children’s hospitals including the Children’s Hospital of Philadelphia, Cincinnati Children’s Hospital Medical Center, Children’s Hospital of Colorado covering over 6.5 million pediatric patients. The accuracy of the estimation was assessed by comparing the results from our ODACoR algorithms with the estimators derived from the meta-analysis and the pooled data. Results The meta-analysis estimator showed a high relative bias (∼40%) when the clinical condition is relatively rare (∼0.5%), whereas ODACoR algorithms exhibited a substantially lower relative bias (∼0.2%). The estimated effects from our ODACoR algorithms were identical on par with the estimates from the pooled data, suggesting the high reliability of our federated learning algorithms. In contrast, the meta-analysis estimate ...
Zhang, D, Tong, J, Stein, R, Lu, Y, Jing, N, Yang, Y, Boland, MR, Luo, C, Baldassano, RN, Carroll, RJ, Forrest, CB & Chen, Y 2024, 'One-shot distributed algorithms for addressing heterogeneity in competing risks data across clinical sites', Journal of Biomedical Informatics, vol. 150, pp. 104595-104595.
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Zhang, L, Jiang, M, Tian, H, Liu, S, Zhou, X, Liu, H, Gan, S, Che, S, Chen, Z, Li, Y, Wang, T, Wang, G & Wang, C 2024, 'Oxygen and Nitrogen Vacancies in a BiOBr/g-C3N4 Heterojunction for Sustainable Solar Ammonia Fertilizer Synthesis', ACS Sustainable Chemistry & Engineering, vol. 12, no. 5, pp. 2028-2040.
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Zhang, L, Wen, S, Khan, JU, Liu, Y, Maddahfar, M, Zhou, J & Jin, D 2024, 'Ultrasensitive Rapid Antigen Test by Geometric Lateral Flow Assays and Highly Doped Upconversion Nanoparticles', Analytical Chemistry, vol. 96, no. 42, pp. 16581-16589.
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Zhang, Q, Lai, N, He, M, Yang, Y, Huang, Q, Quan, Y, Hou, S, Gao, X, Song, Y, Liao, J & Wang, R 2024, 'Tunable broadband luminescence of Bi‐ion‐doped glasses via Gd2O3 co‐doping', Journal of the American Ceramic Society, vol. 107, no. 6, pp. 3837-3844.
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AbstractThe doping of bismuth (Bi) ions in borosilicate glasses has gained attention for its potential applications in LED light sources and imaging displays. Here, gadolinium oxide (Gd2O3) was introduced into the glass matrix in varying concentrations using a high‐temperature melting method to investigate its impact on the luminescence properties of Bi ions. The resulting glass exhibited bimodal emission peaks at 465 and 750 nm when excited with 325 nm light. The luminescence intensity and fluorescence half width at half height initially increased, followed by a subsequent decrease as the Gd2O3 content in the glass increased from 10 to 43 mol%. Additionally, the color of the luminescence transformed from purple–red to green under white light irradiation. The composition and excitation wavelength of the glass can be adjusted to achieve selective tuning of the luminescence.
Zhang, Y, Ran, X, Fu, H, Gong, Y, Li, S, Gu, F, Wang, S, An, X, Su, D & Yang, X 2024, 'Band Alignment Tunning via the Facets of CdS Nanocrystals with g‐C3N4 for Unveiling Their Enhanced Photocatalytical Property', Advanced Functional Materials, vol. 34, no. 44.
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AbstractThe heterojunction is a great approach to profit the photogenerated electrons and holes separation and then enhance the photoelectric current for the photochemical reactions, such as the hydrogen evolution reaction. The intrinsic of the enhanced electrons and hole separation is ascribed to the appropriate band alignment between the two contact materials and plenty of research has reported the different band alignments formed by the different contacted bulk nanomaterials. Few studies focus on the precious crystal structure‐related band alignment. Here, the polyheptazine structured g‐C3N4 together with the wurtzite CdS is investigated, and different band alignments are formed through the different exposed crystal planes of CdS. It is found that along with the annealing temperature, the CdS will dominantly expose with the (110) facets and then form the S‐scheme heterojunction with the g‐C3N4. The formed built‐in electric field between the valence band of CdS and the conductive band of g‐C3N4 accelerates the recombination between the photogenerated electrons from CdS and holes from g‐C3N4. Meanwhile, it promotes the separation of the photogenerated electrons with holes from g‐C3N4, resulting in the superior photocatalytic HER performance. The study supplies a new venue for preciously tunneling the band alignments between the heterogeneous catalysts for optimizing the photoelectric properties.
Zhang, Z, Ma, X, Maeda, EE, Lu, L, Wang, Y, Xie, Z, Li, X, Pan, Y, Huang, L, Zhao, Y & Huete, A 2024, 'Satellite observed dryland greening in Asian endorheic basins: Drivers and implications to sustainable development', Science of The Total Environment, vol. 922, pp. 171216-171216.
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Zhao, F, Guan, Y, Su, F, Du, Z, Wen, S, Zhang, L & Jin, D 2024, 'Lanthanide-Complex-Enhanced Bioorthogonal Branched DNA Amplification', Analytical Chemistry, vol. 96, no. 4, pp. 1556-1564.
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Zhao, H, Li, Y, Mi, C, Zi, Y, Bai, X, Haider, AA, Cun, Y, Huang, A, Liu, Y, Qiu, J, Song, Z, Liao, J, Zhou, J & Yang, Z 2024, 'NIR regeneration and visible luminescence modification in photochromic glass: A novel encryption and 3D optical storage medium', InfoMat, vol. 6, no. 9.
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AbstractPhotochromic glass shows great promise for 3D optical information encryption and storage applications. The formation of Ag nanoclusters by light irradiation has been a significant development in the field of photochromic glass research. However, extending this approach to other metal nanoclusters remains a challenge. In this study, we present a pioneering method for crafting photochromic glass with reliably adjustable dual‐mode luminescence in both the NIR and visible spectra. This was achieved by leveraging bimetallic clusters of bismuth, resulting in a distinct and novel photochromic glass. When rare‐earth‐doped, bismuth‐based glass is irradiated with a 473 nm laser, and it undergoes a color transformation from yellow to red, accompanied by visible and broad NIR luminescence. This phenomenon is attributed to the formation of laser‐induced (Bi+, Bi0) nanoclusters. We achieved reversible manipulation of the NIR luminescence of these nanoclusters and visible rare‐earth luminescence by alternating exposure to a 473 nm laser and thermal stimulation. Information patterns can be inscribed and erased on a glass surface or in 3D space, and the readout is enabled by modulating visible and NIR luminescence. This study introduces a pioneering strategy for designing photochromic glasses with extensive NIR luminescence and significant potential for applications in high‐capacity information encryption, optical data storage, optical communication, and NIR imaging. The exploration of bimetallic cluster formation in Bi represents a vital contribution to the advancement of multifunctional glass systems with augmented optical functionalities and versatile applications.Angewandte Chemie International Edition, vol. 63, no. 29.
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AbstractInactivating hyperactivated transcription factors can overcome tumor therapy resistance, but their undruggable features limit the development of conventional inhibitors. Here, we report that carbon‐centered free radicals (R⋅) can inactivate NF‐κB transcription by capping the active sites in both NF‐κB and DNA. We construct a type of thermosensitive R⋅ initiator loaded amphiphilic nano‐micelles to facilitate intracellular delivery of R⋅. At a temperature of 43 °C, the generated R⋅ engage in electrophilic radical addition towards double bonds in nucleotide bases, and simultaneously cap the sulfhydryl residues in NF‐κB through radical chain reaction. As a result, both NF‐κB nuclear translocation and NF‐κB‐DNA binding are suppressed, leading to a remarkable NF‐κB inhibition of up to 94.1 %. We have further applied R⋅ micelles in a clinical radiofrequency ablation tumor therapy model, showing remarkable NF‐κB inactivation and consequently tumor metastasis inhibition. Radical capping strategy not only provides a method to solve the heat‐sink effect in clinic tumor hyperthermia, but also suggests a new perspective for controllable modification of biomacromolecules in cancer therapy.
Zhao, P, Li, H, Sun, B, Wang, C, Lv, G, Chen, C, Ying, L, He, X, Jin, D & Bu, W 2024, 'Carbon Free Radical (R⋅) Inactivates NF‐κB for Radical Capping Therapy', Angewandte Chemie, vol. 136, no. 29.
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AbstractInactivating hyperactivated transcription factors can overcome tumor therapy resistance, but their undruggable features limit the development of conventional inhibitors. Here, we report that carbon‐centered free radicals (R⋅) can inactivate NF‐κB transcription by capping the active sites in both NF‐κB and DNA. We construct a type of thermosensitive R⋅ initiator loaded amphiphilic nano‐micelles to facilitate intracellular delivery of R⋅. At a temperature of 43 °C, the generated R⋅ engage in electrophilic radical addition towards double bonds in nucleotide bases, and simultaneously cap the sulfhydryl residues in NF‐κB through radical chain reaction. As a result, both NF‐κB nuclear translocation and NF‐κB‐DNA binding are suppressed, leading to a remarkable NF‐κB inhibition of up to 94.1 %. We have further applied R⋅ micelles in a clinical radiofrequency ablation tumor therapy model, showing remarkable NF‐κB inactivation and consequently tumor metastasis inhibition. Radical capping strategy not only provides a method to solve the heat‐sink effect in clinic tumor hyperthermia, but also suggests a new perspective for controllable modification of biomacromolecules in cancer therapy.
Zhao, S, Li, G, Zhang, B, Li, T, Luo, M, Sun, B, Wang, G & Guo, S 2024, 'Technological roadmap for potassium-ion hybrid capacitors', Joule, vol. 8, no. 4, pp. 922-943.
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Zheng, J, Xue, C, Wang, G, Mahmud, MA, Sun, Z, Liao, C, Yi, J, Qu, J, Yang, L, Wang, L, Bremner, S, Cairney, JM, Zhang, J & Ho-Baillie, AWY 2024, 'Efficient Flexible Monolithic Perovskite–CIGS Tandem Solar Cell on Conductive Steel Substrate', ACS Energy Letters, vol. 9, no. 4, pp. 1545-1547.
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Zheng, X, Yang, J, Xu, X, Dou, S, Sun, W, Wang, D & Wang, G 2024, 'Deciphering Cationic and Anionic Overoxidation: Key Insights into the Intrinsic Structural Degradation of Catalysts', Advanced Energy Materials, vol. 14, no. 30.
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AbstractProton exchange membrane water electrolyzer (PEMWE) technology holds tremendous promise for large‐scale green hydrogen production. However, its widespread application faces significant constraints due to the limited lifespan of the oxygen evolution reaction (OER) catalyst in highly acidic and oxidative operating environments. Therefore, a comprehensive understanding of the catalyst's structural degradation mechanism is imperative for the rational design of high‐performance acidic catalysts. In this review, the essence of the structural degradation of catalysts: and irreversible cationic and anionic overoxidation is initially unveiled. This is followed by an in‐depth exploration of their intricate relationship with the adsorbate evolution mechanism (AEM) and lattice oxygen oxidation mechanism (LOM). Then, state‐of‐the‐art characterization techniques for cationic and anionic overoxidation analysis are introduced. Subsequently, 4 cutting‐edge catalyst antioxidation strategies, including heterostructure engineering, doping strategy, nanostructuring, and phase engineering are systematically discussed, aiming to reveal their intrinsic factors for effectively inhibiting catalyst overoxidation. Finally, the remaining challenges and prospective insights into catalysts for PEMWE are delineated. The overarching goal of this review is to facilitate a fundamental understanding of catalyst structural degradation mechanisms and provide principal guidelines for the rational design of robust acidic OER catalysts.
Zhou, X, Wang, T, He, D, Chen, P, Liu, H, Lv, H, Wu, H, Su, D, Pang, H & Wang, C 2024, 'Efficient Photocatalytic Desulfurization in Air through Improved Photogenerated Carriers Separation in MOF MIL101/Carbon Dots‐g‐C3N4 Nanocomposites', Angewandte Chemie International Edition, vol. 63, no. 35.
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AbstractThe extensive industrial applications of fuel oil, a critical strategic resource, are accompanied by significant environmental and health concerns due to the presence of sulfur‐containing compounds in its composition, which result in hazardous combustion waste. Extensive research has been conducted to develop technologies for low‐vulcanization fuel production to address this issue. Consequently, the investigation of catalysts for environmentally friendly and safe photocatalytic desulfurization becomes imperative. To that end, we have designed efficient MIL‐101(Fe)/CQDs@g‐C3N4 (MIL101/CDs‐C3N4) Z‐scheme heterojunction photocatalysts with high carrier separation and mobility through a thermal polymerization‐hydrothermal strategy. The high concentration of photogenerated carriers facilitates the activation of oxygen and H2O2, leading to increased production of ROS (⋅O2−, ⋅OH, h+), thereby enhancing the photocatalytic desulfurization (PODS). Additionally, DFT (Density functional theory) calculations were utilized to determine the electron migration pathways of the catalysts and adsorption energies of DBT (dibenzothiophene). Moreover, Gibbs free energy calculations indicated that MIL101/CDs‐C3N4 exhibited the lowest activation energy for oxygen and H2O2. The mechanism of photocatalytic desulfurization was proposed through a combination of theoretical calculations and experimental studies. This study provides guidance for the development of MOF‐based Z‐scheme systems and their practical application in desulfurization processes.
Zhou, X, zhang, L, Liu, H, Yang, Q, Zhu, S, Wu, H, Ohno, T, Zhang, Y, Wang, T, Su, D & Wang, C 2024, 'The powerful combination of 2D/2D Ni-MOF/carbon nitride for deep desulfurization of thiophene in fuel: Conversion route, DFT calculation, mechanism', Journal of Colloid and Interface Science, vol. 658, pp. 627-638.
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Zhu, X, Huang, A, Zhao, H, Liu, Y, Cun, Y, Song, Z, Qiu, J, Tatiana, C, Liao, J & Yang, Z 2024, 'Defects‐Induced Photochromism and Luminescent Modulation Based on Lanthanides‐Doped Cadmium Glass Toward Optical Storage Applications', Laser & Photonics Reviews, vol. 18, no. 6.
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AbstractOwing to the large storage capacity, the transparent luminescent glass with photo‐induced coloration properties has attracted considerable interest in recent years. However, lots of the photochromic (PC) mechanisms for glass are related to the ionic valence transformation, and the study associated with the defects‐induced photochromism of glass is limited. Herein, a kind of Sm3+ doped PC cadmium glass is fabricated, for which the PC mechanism is systematically investigated by various techniques, such as XPS spectra, thermoluminescence spectra, EPR spectra, etc. The results show that the mechanism of coloration for such glass should be due to the presence of oxygen vacancy‐related electron centers. Under 365 nm light irradiation, the color of the glass turns from colorless to brown, exhibiting a large color contrast, of 62%. Utilizing the re‐absorption process between absorption spectra and emission/excitation spectra, the emission intensity of Sm3+ is reversibly regulated, indicating their promising applications as an optical storage medium.
Zhu, X, Ma, X, Zhang, Z, Liu, Y, Luo, Y, Yan, K, Pei, T & Huete, A 2024, 'Floating in the air: forecasting allergenic pollen concentration for managing urban public health', International Journal of Digital Earth, vol. 17, no. 1.
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