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Books
Eggleton, BJ, Steel, MJ & Poulton, CG 2022, Preface, Elsevier.
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Chapters
Aganetti, MA, Cruz, CS, Galvão, I, Engels, DF, Ricci, MF & Vieira, AT 2022, 'The Gut Microbiota and Immunopathophysiology' in Comprehensive Pharmacology, Elsevier, pp. 492-514.
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Ben-Nissan, B, Choi, G, Choi, AH, Karacan, I & Evans, L 2022, 'Natural and Synthetic Intelligent Self-healing and Adaptive Materials for Medical and Engineering Applications' in Springer Series in Biomaterials Science and Engineering, Springer Singapore, pp. 89-124.
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Blumenthal, DJ, Kabakova, I, Rakich, PT & Vahala, K 2022, 'Integrated Brillouin lasers and their applications' in Semiconductors and Semimetals, Elsevier, pp. 107-180.
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In this chapter we give a brief history of the Brillouin gain process in optical waveguides and SBLs realized with integrated Brillouin resonators. A brief discussion on the laser fundamental and integral linewidths, the fractional frequency noise, and drift is provided. We discuss progress to date on Brillouin processes in integrated silica, silicon nitride, silicon, and chalcogenide platforms. The underlying Brillouin physics in waveguide materials and the range of waveguide structures and related requirements for photon–phonon phase matching are covered as well as research efforts to implement SBS gain and lasing in these waveguide material systems. Cascaded Brillouin lasing is discussed, including mode engineering approaches to inhibit cascading to enable further linewidth narrowing and higher output powers. Finally, several applications using these integrated Brillouin technologies are presented.
Bourke, JE, Ammit, AJ, Burgess, JK, Gosens, R, Halayko, AJ, Seow, C & Hirst, SJ 2022, 'Smooth Muscle Cells' in Encyclopedia of Respiratory Medicine, Elsevier, pp. 37-51.
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Chowdhury, PR, Stokes, HW & Labbate, M 2022, 'Integrons' in Bacterial Integrative Mobile Genetic Elements, CRC Press, pp. 53-69.
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Chowdhury, PR, Stokes, HW & Labbate, M 2022, 'Intégrons: Antibiotic resistance evolution and beyond' in Roberts, AP & Mullany, P (eds), Bacterial Integrative Mobile Genetic Elements, Landes Bioscience, Austin, Texas USA, pp. 53-69.
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Intégrons include a site-specific recombination system that can capture gene cassettes. Gene cassettes are the smallest known mobilizable units of DNA and normally only comprise a single gene and a recombination site essential for the site-specific recombination event to occur. Although the site specific recombination reaction is catalyzed by an integrase protein that is a member of the tyrosine family of site specific recombinases, the biology and biochemistry of the system is unusual in a number of respects. Most notably, gene cassettes comprise a family of elements that are highly diverse both with respect to the genes and the recombination sites within them. Intégrons first came to prominence as a consequence of their infiltrating pathogenic Gram negative bacteria. In this context intégrons commonly possess multiple cassettes with the associated genes conferring, collectively, resistance to a wide range of clinically important antibiotics. As a consequence they are one of the single biggest contributors to the evolution of antibiotic resistant bacteria. Intégrons however are ancient structures that are widely distributed among the Proteobacteria. In the broader context, cassette associated genes are remarkably diverse and highly novel. This mobile cassette 'metagenome' includes a pool of novel gene cassettes potentially available to whole microbial communities. While the function of most cassette genes in this pool remains unknown, it is clear that they are rich source of innovation and novelty.
Clerc, EE, Raina, J-B, Peaudecerf, FJ, Seymour, JR & Stocker, R 2022, 'Survival in a Sea of Gradients: Bacterial and Archaeal Foraging in a Heterogeneous Ocean' in The Microbiomes of Humans, Animals, Plants, and the Environment, Springer International Publishing, pp. 47-102.
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Das, SS, Moitra, I, Das, S, Singh, N, Verma, PRP & Singh, SK 2022, 'Conventional to Nanoscale-Based Carrier Systems in the Management of Ovarian Cancer' in Hormone Related Cancer Mechanistic and Nanomedicines, Springer Nature Singapore, pp. 89-110.
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Devkota, HP, Adhikari-Devkota, A, Paudel, KR, Panth, N, Gupta, G, Chellappan, DK, Hansbro, PM & Dua, K 2022, 'Phytochemicals and their Nanoformulations Targeted for Pulmonary Diseases' in Chellappan, DK, Pabreja, K & Faiyazuddin, M (eds), Advanced Drug Delivery Strategies for Targeting Chronic Inflammatory Lung Diseases, Springer Singapore, Singapore, pp. 95-106.
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Plant-derived natural products, also known as phytochemicals, are one of the most important sources of drug discovery. Due to their wide abundance in nature and structural diversity, various phytochemicals are gaining research interest for the discovery and development of effective therapeutic agents for various diseases, including lung diseases. Bioavailability and metabolism have been the main limiting factors for the effective use of these phytochemicals. In recent years, various novel drug delivery systems, including nanoformulations, have been evaluated for the effective delivery of these phytochemicals. This chapter will cover research related to the potential use of phytochemicals (e.g., polyphenols, alkaloids, steroids) and their nanoformulations in lung diseases.
Elbeltagi, A, Kushwaha, NL, Srivastava, A & Zoof, AT 2022, 'Artificial intelligent-based water and soil management' in Deep Learning for Sustainable Agriculture, Elsevier, pp. 129-142.
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Artificial intelligence (AI) has revolutionized information technology and shaped the way we live. AI is a computational model that allows computers to learn from data and approximate solutions for complex functions. Due to their flexibility and robustness, AI has been widely applied in large scale fields ranging from robotics to airplane flight control. This chapter discusses the advances in all aspect of AI applied in several issues, such as hydrology, agronomy, meteorology, education, healthcare, action, and more. It focuses specifically on various AI applications related to water and soil management and states that AI achieves high performance, accuracy, and correlation with low statistical errors as a rapid decision tool under changing climate conditions. Brief introductions of AI with their adaptability to agricultural water and soil management are also interpreted. Furthermore, this chapter illustrates how the AI tool will help agricultural decision makers and water and soil managers achieve agricultural sustainability.
Hasan, S, Mahmud, MAP & Kouzani, AZ 2022, 'Additively Manufactured Biomedical Energy Harvesters' in Additive Manufacturing in Biomedical Applications, ASM International, pp. 440-453.
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Hossain, SI, Islam, MZ, Saha, SC & Deplazes, E 2022, 'Drug Meets Monolayer: Understanding the Interactions of Sterol Drugs with Models of the Lung Surfactant Monolayer Using Molecular Dynamics Simulations' in Methods in Molecular Biology, Springer US, Switzerland, pp. 103-121.
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The lung surfactant monolayer (LSM) is a thin layer of lipids and proteins that forms the air/water interface of the alveoli. The primary function of the LSM is to reduce the surface tension at the air/water interface during breathing. The LSM also forms the main biological barrier for any inhaled particles, including drugs, to treat lung diseases. Elucidating the mechanism by which these drugs bind to and absorb into the LSM requires a molecular-level understanding of any drug-induced changes to the morphology, structure, and phase changes of the LSM.Molecular dynamics simulations have been used extensively to study the structure and dynamics of the LSM. The monolayer is usually simulated in at least two states: the compressed state, mimicking exhalation, and the expanded state, mimicking inhalation. In this chapter, we provide detailed instructions on how to set up, run, and analyze coarse-grained MD simulations to study the concentration-dependent effect of a sterol drug on the LSM, both in the expanded and compressed state.
Ikram, M, Raza, A, Ikram, M & Mahmood, A 2022, 'Carbon Nanocomposite-Based SCs as Wearable Energy Storage' in Advances in Material Research and Technology, Springer International Publishing, pp. 451-483.
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Irga, P & Torpy, F 2022, 'Understanding the impacts of air pollution on human experience: Two case studies' in Grau, U & Fernandez-Abascal, G (eds), Folk Costumes, Indo-Pacific Air, Art Paper Editions, Ghent, Begium, pp. 128-135.
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It has long been known that substances in the air can have adverse effects on human health. Today, with the impacts of climate change and human activity changing the world in untold ways, air pollution represents a considerable and global threat to our health. Between 2005 and 2010, the death rate associated with exposure to outdoor air pollution increased globally by 4 per cent, by 5 per cent in China and by a staggering 12 per cent in India (Kumar et al., 2019). The Organisation for Economic Co-operation and Development (OECD) has stated thatoutdoor air pollution exposure is predicted to become the leading environmental cause of premature death by 2050 (WHO Regional Office for Europe, 2015). In 2012 alone, it was estimated that approximately 7 million deaths were related to outdoor air pollution (World Health Organization, 2016). Pollution exposure also has a negative impact on economies, with a reported ~USD$ 1.7 trillion spent on health-related costs in 2010 (Kitamori et al., 2012).Whilst a proportion of air pollution results from natural processes such as bushfire smoke, pollen release and surface dust, in cities large quantities of pollutants are produced from fossil fuel emissions, which comprise a mixture of solid particulate matter (PM) and gases, including oxides of sulphur (SOx), oxides of nitrogen (NOx), carbon monoxide (CO), carbon dioxide (CO2), and ozone (Bai et al., 2018).By examining industrial pollution in China and the pollution resulting from the recent Australian bushfires, we can see how our changing planet is influencing both manmade and biomass generated sources of air pollution. But first, it is important to have an understanding of the pollutants and their risk profiles.
Jelocnik, M, Huston, WM & Newton, HJ 2022, '
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Kabakova, I, Scarcelli, G & Yun, S-H 2022, 'Brillouin light scattering in biological systems' in Semiconductors and Semimetals, Elsevier, pp. 313-348.
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The past 20 years have seen new application of the physics of Brillouin light scattering to the fields of biology, bioengineering, and biomedicine. Mapping of the 3D micromechanical properties of biological systems with the focused beam of light holds great potential to provide new insights in the range of fundamental biology questions related to cell–matrix interactions, cell differentiation, and pathogenesis. In this chapter we introduce the main principles on which the field of BioBrillouin imaging stands, discuss major technological developments in the instrumentations of Brillouin microscopy, and provide a brief overview of key applications of this technology to various fields of biology and medicine.
Karacan, I, Milthorpe, B, Ben-Nissan, B & Santos, J 2022, 'Stem Cells and Proteomics in Biomaterials and Biomedical Applications' in Springer Series in Biomaterials Science and Engineering, Springer Singapore, pp. 125-157.
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Kuzhiumparambil, U, Kumar, M, Nizio, KD, Alonso, D, Gorst-Allman, P, Kelly, C, MacLeod, B, Forbes, S & Ralph, P 2022, 'Metabolomic profiling of anthropogenically threatened Australian seagrass Zostera muelleri using one- and two-dimensional gas chromatography' in Applied Environmental Metabolomics, Elsevier, pp. 135-151.
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The global decline of seagrass meadows due to sustained pressure from anthropogenic activities and the ongoing threat from climate change has weakened their capacity for supporting coastal productivity and fisheries habitats, while also increasing sediment erosion. The ongoing efforts to prevent seagrass decline require novel tools to monitor seagrass health and assess the effects of habitat management. Such monitoring tools require the use of sensitive indicators to assess the intensity of environmental stressors and to monitor the corresponding responses of seagrass. Environmental metabolomics has proven valuable in identifying such phenotypic traits of abiotic and biotic stress in plants. The identification of metabolite changes in seagrass linked to an environmental stress response may lead to the development of a molecular diagnostic tool that could be used to give an early warning of seagrass stress. Therefore, we explore the potential of one- and two-dimensional gas chromatography coupled with time-of-flight mass spectrometry (1D and 2D GC-TOFMS) in Australia’s most threatened seagrass species—Zostera muelleri. Overall, GC×GC-TOFMS outperformed GC-TOFMS and offered a robust, comprehensive, and superior analytical sensitivity and resolution with a total of 156 metabolites compared to 93 identified in GC-TOFMS. Among these metabolites, > 50% were identified exclusively in GC×GC-TOFMS and include secondary metabolites of the phenylpropenoid class, phytohormones, and various sugar and amino acid derivatives. Therefore, GC×GC-TOFMS represents a comprehensive metabolomics platform for both discovery and targeted studies in seagrass that may aid diagnostic tool development for more targeted seagrass management.
Lawson, CA, Camp, E, Davy, SK, Ferrier-Pagès, C, Matthews, J & Suggett, DJ 2022, 'Informing Coral Reef Conservation Through Metabolomic Approaches' in Coral Reefs of the World, Springer International Publishing, pp. 179-202.
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Macha, IJ & Ben-Nissan, B 2022, 'Past and Future of Wound Dressing in Soft and Hard Tissue Surgery' in Springer Series in Biomaterials Science and Engineering, Springer Singapore, pp. 1-14.
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Mahmud, MAP & Tasmin, N 2022, 'Environmental impact assessment of battery storage' in Environmental Assessment of Renewable Energy Conversion Technologies, Elsevier, pp. 277-302.
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Mahmud, MAP & Tasmin, N 2022, 'Environmental impact assessment of hydropower stations' in Environmental Assessment of Renewable Energy Conversion Technologies, Elsevier, pp. 213-230.
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Matthews, JL, Cunning, R, Witson-Williams, R, Oakley, CA, Lutz, A, Roessner, U, Grossman, AR, Weis, VM, Gates, RD & Davy, SK 2022, 'The metabolic significance of symbiont community composition in the coral-algal symbiosis' in Applied Environmental Metabolomics, Elsevier, pp. 211-229.
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McCauley, JI, Ortega, JS, Gentile, C & Ralph, PJ 2022, 'Chapter 7 Microalgal applications in biomedicine and healthcare' in Algae-Based Biomaterials for Sustainable Development, Elsevier, pp. 133-156.
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McCauley, JI, Ortega, JS, Gentile, C & Ralph, PJ 2022, 'Microalgal applications in biomedicine and healthcare' in Algae-Based Biomaterials for Sustainable Development, Elsevier, pp. 133-156.
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The field of research that explores the use of microalgae in biomedicine and health is complex and diverse. Numerous research avenues currently explore the use of microalgae in biomedicine and heath such as: focusing on establishing and boosting nutritional profiles for food applications; identification, characterisation and utilisation of microalgal metabolites with biological activity as functional ingredients and/or drugs; utilisation of recombinant technology to genetically modify the algae for use as production systems for enzymes, antibodies, growth factors, drugs, and vaccines; or the use of microalgae as a source of “biomaterial” for use in applications such as drug carriers or cellular scaffolds for tissue engineering. To illustrate the diversity of microalgae and its potential for utilisation in a wide variety of biomedical and heath care applications, this chapter will present a concise overview of this broad applicability of microalgae in biomedicine and health, while highlighting research that is also occurring into the production and biorefinery of these compounds to facilitate a viable transition from laboratory to commercial production. Thus, this chapter aims to bridge the knowledge gap between both existing and potentially new algae applications, in particular, the use of microalgae as a source of “biomaterials” for biomedicine and health applications.
Mirakhorli, F, Mohseni, SS, Bazaz, SR, Mehrizi, AA, Ralph, PJ & Warkiani, ME 2022, 'Microfluidic Platforms for Cell Sorting' in Sustainable Separation Engineering: Materials, Techniques and Process Development, Wiley, pp. 653-695.
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Microfluidic platforms have evolved in recent years to assist researchers and biologists in performing biological and medical assays for cell separation and sorting. These microfluidic systems are competitive alternatives to conventional methods in terms of cost, sample volume reduction, high sensitivity, portability, fast processing, and elimination of chemical labels required for detection. In this chapter, these techniques have been classified into two major groups, active and passive, based on their energy intake and operating standards. Each separation technique was described briefly, and their operational principles were explained in detail. To specify the applications of each technique, the most recent popular examples have been explained along with common metrics used for the evolution of microfluidic system, including efficiency, accuracy, and throughput. This chapter is designed to be helpful for researchers who aim to develop unique microfluidic separator systems with further innovative designs in microfluidic platforms.
Ngo, HH, Vo, HNP, Guo, W, Lee, D-J & Zhang, S 2022, 'Carbon dioxide fixation and phycoremediation by algae-based technologies for biofuels and biomaterials' in Biomass, Biofuels, Biochemicals, Elsevier, pp. 253-277.
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Nguyen, LN, Vu, MT, Vu, HP, Zdarta, J, Mohammed, JAH, Pathak, N, Ralph, PJ & Nghiem, LD 2022, 'Chapter 4 Seaweed carrageenans: Productions and applications' in Algae-Based Biomaterials for Sustainable Development, pp. 67-80.
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Nguyen, LN, Vu, MT, Vu, HP, Zdarta, J, Mohammed, JAH, Pathak, N, Ralph, PJ & Nghiem, LD 2022, 'Seaweed carrageenans: Productions and applications' in Algae-Based Biomaterials for Sustainable Development, Elsevier, pp. 67-80.
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Nucera, F, Hansbro, PM, Paudel, KR, Casolaro, V, Appanna, R, Kirkham, P, Adcock, IM & Caramori, G 2022, 'Role of autoimmunity in the pathogenesis of chronic obstructive pulmonary disease and pulmonary emphysema' in Translational Autoimmunity, Elsevier, pp. 311-331.
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Pilz, KF & Schlögl, E 2022, 'A hybrid commodity and interest rate market model' in Commodities: Fundamental Theory of Futures, Forwards, and Derivatives Pricing, Chapman and Hall/CRC, pp. 469-496.
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Poulton, CG, Steel, MJ, Wiederhecker, G & Thévenaz, L 2022, 'Historical perspective and basic principles' in Semiconductors and Semimetals, Elsevier, pp. 1-25.
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We give a broad overview of the historical development and physics of Brillouin scattering. We discuss the seminal papers of Brillouin and Mandelstam and give the historical context of their research. We discuss the development of experiments and observations from the early, prelaser work to the present day. We then give a broad, nonmathematical explanation of Brillouin scattering as it is currently understood, and outline the different types of scattering as well as the conditions under which it occurs.
Prasher, P, Sharma, M, Kapoor, DN, Negi, P, Gupta, G, Zacconi, FC, Tambuwala, MM, Mehta, M, Satija, S, Dureja, H, Chellappan, DK & Dua, K 2022, 'Chemical Moieties as Advanced Therapeutics for Targeting Respiratory Disorders' in Advanced Drug Delivery Strategies for Targeting Chronic Inflammatory Lung Diseases, Springer Singapore, pp. 75-93.
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Sadaqat, M, Tabassum, H, Tianjie, Q, Mahmood, A, Nisar, L & Naeem Ashiq, M 2022, 'Hierarchical porous carbon-incorporated metal-based nanocomposites for secondary metal-ion batteries' in Metal Oxide-Carbon Hybrid Materials, Elsevier, pp. 179-216.
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Sahoo, JP, Tripathy, AK, Mohanty, M, Li, KC & Nayak, AK 2022, 'Preface', pp. xiii-xiv.
Satija, S, Dhanjal, DS, Sharma, P, Hussain, MS, Chan, Y, Ng, SW, Prasher, P, Dureja, H, Chopra, C, Singh, R, Gupta, G, Chellappan, DK, Dua, K & Mehta, M 2022, 'Vesicular Drug Delivery Systems in Respiratory Diseases' in Advanced Drug Delivery Strategies for Targeting Chronic Inflammatory Lung Diseases, Springer Singapore, pp. 125-141.
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Schotsmans, EMJ, Georges-Zimmermann, P, Ueland, M & Dent, BB 2022, 'From Flesh to Bone' in The Routledge Handbook of Archaeothanatology, Routledge, pp. 500-541.
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Shahid, M, Khurshid, M, Mehmood, MA, Malik, S, Manzoor, I & Muhammad, S 2022, 'Bacterial Contamination in Food Chain: Sources, Impact and Control' in Climate Change and Ecosystems, CRC Press, pp. 203-216.
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Stadler, F, Johnston, NP, Butterworth, NJ & Wallman, JF 2022, '13. Fly Colony Establishment, Quality Control and Improvement' in A Complete Guide to Maggot Therapy, Open Book Publishers, pp. 257-288.
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Sunkara, K, Mehta, M, Satija, S, Dhanjal, DS, Sharma, P, Shukla, SD, Shastri, M, Zacconi, FC, Dua, K & Allam, VSRR 2022, 'An Introduction to Respiratory Diseases and an Emerging Need for Efficient Drug Delivery Systems' in Advanced Drug Delivery Strategies for Targeting Chronic Inflammatory Lung Diseases, Springer Singapore, pp. 1-24.
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Szabo, EA, Arundell, EJ, Farrell, H, Imlay, A, King, T, Shadbolt, C & Taylor, MD 2022, 'Responding to incidents of low-level chemical contamination and deliberate contamination in food' in Ensuring Global Food Safety, Elsevier, pp. 359-377.
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Vo, HNP, Chaiwong, C, Zheng, L, Nguyen, TMH, Koottatep, T & Nguyen, TT 2022, 'Algae-based biomaterials in 3D printing for applications in medical, environmental remediation, and commercial products' in Algae-Based Biomaterials for Sustainable Development, Elsevier, pp. 185-202.
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Wadhwa, R, Paudel, KR, Shukla, S, Shastri, M, Gupta, G, Devkota, HP, Bebawy, M, Chellappan, DK, Hansbro, PM & Dua, K 2022, 'Epigenetic Therapy as a Potential Approach for Targeting Oxidative Stress–Induced Non-small-Cell Lung Cancer' in Handbook of Oxidative Stress in Cancer: Mechanistic Aspects, Springer Nature Singapore, pp. 1545-1560.
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Wadhwa, R, Paudel, KR, Shukla, S, Shastri, M, Gupta, G, Devkota, HP, Chellappan, DK, Hansbro, PM & Dua, K 2022, 'Epigenetic Therapy as a Potential Approach for Targeting Oxidative Stress–Induced Non-Small-Cell Lung Cancer' in Handbook of Oxidative Stress in Cancer: Mechanistic Aspects, Springer Singapore, pp. 1-16.
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Wang, Y, Zhou, D & Wang, G 2022, 'Sulfur-Containing Polymer Cathode Materials for Li–S Batteries' in Modern Aspects of Electrochemistry, Springer International Publishing, pp. 295-330.
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Waqas Hakim, M, Fatima, S, Rizwan, S & Mahmood, A 2022, 'Pseudo-capacitors: Introduction, Controlling Factors and Future' in Advances in Material Research and Technology, Springer International Publishing, pp. 53-70.
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Wolff, C, Poulton, CG, Steel, MJ & Wiederhecker, G 2022, 'Theoretical formalisms for stimulated Brillouin scattering' in Semiconductors and Semimetals, Elsevier, pp. 27-91.
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We present the theoretical formalism for Brillouin scattering, beginning with the equations for linear elasticity together with Maxwells equations, and ending with the equations of motion for the optical and acoustic envelope fields. The treatment presented here is based on the Hamiltonian for the opto-acoustic interaction, but we discuss other possible derivations, as well as alternate formulations that describe Brillouin phenomena. We cover the theory of Brillouin scattering in both waveguides and resonators, and present the equations for several typical settings in each case. An Appendix gives a brief introduction to linear elasticity theory for optical physicists.
Journal articles
Aamidor, SE, Cardoso-Júnior, CAM, Harianto, J, Nowell, CJ, Cole, L, Oldroyd, BP & Ronai, I 2022, 'Reproductive plasticity and oogenesis in the queen honey bee (Apis mellifera)', Journal of Insect Physiology, vol. 136, pp. 104347-104347.
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In the honey bee (Apis mellifera), queen and worker castes originate from identical genetic templates but develop into different phenotypes. Queens lay up to 2000 eggs daily whereas workers are sterile in the queen's presence. Periodically queens stop laying: during swarming, when resources are scarce in winter, and when they are confined to a cage by beekeepers. We used confocal microscopy and gene expression assays to investigate the control of oogenesis in the ovaries of honey bee queens that were caged inside and outside the colony. We find evidence that queens use a different combination of 'checkpoints' to regulate oogenesis compared to honey bee workers and other insect species. However, both queen and worker castes likely use the same programmed cell death pathways to terminate oocyte development at their caste-specific checkpoints. Our results also suggest that a key factor driving the termination of oogenesis in queens is nutritional stress. Thus, queens may regulate oogenesis via the same regulatory pathways that were utilised by ancestral solitary species but likely have adjusted physiological checkpoints to suit their highly-derived life history.
Abayarathna, T & Webb, JK 2022, 'Consequences of Oviposition Site Choice for Geckos in Changing Environments', Biology, vol. 11, no. 9, pp. 1281-1281.
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Abdelhafiz, A, Wang, B, Harutyunyan, AR & Li, J 2022, 'Carbothermal Shock Synthesis of High Entropy Oxide Catalysts: Dynamic Structural and Chemical Reconstruction Boosting the Catalytic Activity and Stability toward Oxygen Evolution Reaction', Advanced Energy Materials, vol. 12, no. 35.
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Abdollahi, A, Liu, Y, Pradhan, B, Huete, A, Dikshit, A & Nguyen Tran, N 2022, 'Short-time-series grassland mapping using Sentinel-2 imagery and deep learning-based architecture', The Egyptian Journal of Remote Sensing and Space Sciences, vol. 25, no. 3, pp. 673-685.
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In the present work, a deep learning-based network called LeNet is applied for accurate grassland map production from Sentinel-2 data for the Greater Sydney region, Australia. First, we apply the technique to the base date Sentinel-2 data (non-seasonal) to make the vegetation maps. Then, we combine short time-series (seasonal) data and enhanced vegetation index (EVI) information to the base date imagery to improve the classification results and generate high-resolution grassland maps. The proposed model obtained an overall accuracy (OA) of 88.36% for the mono-temporal data, and 92.74% for the multi-temporal data. The experimental products proved that, by combining the short time-series images and EVI information to the base date, the classification maps' accuracy is increased by 4.38%. Moreover, the Sentinel-2 produced grassland maps are compared with the pre-existing maps such as Australian Land Use and Management (ALUM) 50 m resolution and Dynamic Land Cover Dataset (DLCD) with 250 m resolution as well as some traditional machine learning methods such as Support Vector Machine (SVM) and Random Forest (RF). The results show the effect of the LeNet network's performance and efficiency for grassland map production from short time-series data. As a result, decision-makers and urban planners can benefit from this work in terms of grassland change identification, monitoring, and planning assessment.
Abell-King, C, Costas, A, Duggin, IG & Söderström, B 2022, 'Bacterial filamentation during urinary tract infections', PLOS Pathogens, vol. 18, no. 12, pp. e1010950-e1010950.
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Abiero, AR, Ali, Z, Vissel, B & Bradfield, LA 2022, 'Outcome-selective reinstatement is predominantly context-independent, and associated with c-Fos activation in the posterior dorsomedial striatum', Neurobiology of Learning and Memory, vol. 187, pp. 107556-107556.
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Research from human and animal studies has found that after responding has been successfully reduced following treatment it can return upon exposure to certain contexts. An individual in recovery from alcohol use disorder, for example, might relapse to drinking upon visiting their favourite bar. However, most of these data have been derived from experiments involving a single (active) response, and the context-dependence of returned responding in situations involving choice between multiple actions and outcomes is less well-understood. We thus investigated how outcome-selective reinstatement - a procedure involving choice between two actions and outcomes - was affected by altering the physical context in rats. In Experiment 1, rats were trained over 6 days to press a left lever for one food outcome (pellets or sucrose) and a right lever for the other outcome. Then, rats received an extinction session in either the same context (A) as lever press training, or in a different context (B). Rats were tested immediately (5 min) after extinction in Context A or B such that there were four groups in total: AAA, ABB, ABA, and AAB. Reinstatement testing consisted of one food outcome being delivered 'freely' (i.e. unearned by lever pressing and unsignalled by cues) to the food magazine every 4 min in the following order: Sucrose, Pellet, Pellet, Sucrose. Selective reinstatement was considered intact if pellet delivery increased pressing selectively on the pellet lever, and sucrose delivery selectively increased pressing on the sucrose lever. This result (Reinstated > Nonreinstated) was observed for rats in group AAA and ABB, but not rats in groups ABA and AAB. Experiment 2 was conducted identically, except that rats received two extinction sessions over two days and tested one day later. This time, all groups demonstrated intact outcome-selective reinstatement regardless of context. Analysis of c-Fos expression in several brain regions revealed that only c-Fos exp...
Abolpour Moshizi, S, Pastras, CJ, Sharma, R, Parvez Mahmud, MA, Ryan, R, Razmjou, A & Asadnia, M 2022, 'Recent advancements in bioelectronic devices to interface with the peripheral vestibular system', Biosensors and Bioelectronics, vol. 214, pp. 114521-114521.
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Abu Bakar, NA, Ali, S, Hisamuddin, SN, Supangat, A, Langford, SJ & Roslan, NA 2022, 'Effect of different deposition techniques of PCDTBT:PC71BM composite on the performance of capacitive-type humidity sensors', Synthetic Metals, vol. 285, pp. 117020-117020.
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Adhikari, S, Timms, W & Mahmud, MAP 2022, 'Optimising water holding capacity and hydrophobicity of biochar for soil amendment – A review', Science of The Total Environment, vol. 851, pp. 158043-158043.
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Adhikary, P, Mahmud, MAP, Solaiman, T & Wang, ZL 2022, 'Recent advances on biomechanical motion-driven triboelectric nanogenerators for drug delivery', Nano Today, vol. 45, pp. 101513-101513.
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Afrose, D, Chen, H, Ranashinghe, A, Liu, C-C, Henessy, A, Hansbro, PM & McClements, L 2022, 'The diagnostic potential of oxidative stress biomarkers for preeclampsia: systematic review and meta-analysis', Biology of Sex Differences, vol. 13, no. 1, p. 26.
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Aharonovich, I 2022, 'Quantum dots light up ahead', Photonics Insights, vol. 1, no. 2, pp. C04-C04.
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Aili, SR, De Silva, R, Wilhelm, K, Jha, SR, Fritis-Lamora, R, Montgomery, E, Pierce, R, Lam, F, Brennan, X, Gorrie, N, Schnegg, B, Jabbour, A, Kotlyar, E, Muthiah, K, Keogh, AM, Jansz, PC, Hayward, C & Macdonald, PS 2022, 'Validation of Cognitive Impairment in Combination With Physical Frailty as a Predictor of Mortality in Patients With Advanced Heart Failure Referred for Heart Transplantation', Transplantation, vol. 106, no. 1, pp. 200-209.
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Ajani, PA, Henriquez-Nunez, HF, Verma, A, Nagai, S, Uchida, H, Tesoriero, MJ, Farrell, H, Zammit, A, Brett, S & Murray, SA 2022, 'Mapping the development of a Dinophysis bloom in a shellfish aquaculture area using a novel molecular qPCR assay', Harmful Algae, vol. 116, pp. 102253-102253. Akkaya Hocagil, T, Ryan, LM, Cook, RJ, Jacobson, SW, Richardson, GA, Day, NL, Coles, CD, Carmichael Olson, H & Jacobson, JL 2022, 'A hierarchical meta‐analysis for settings involving multiple outcomes across multiple cohorts', Stat, vol. 11, no. 1. Albariqi, AH, Wang, Y, Chang, RYK, Quan, DH, Wang, X, Kalfas, S, Drago, J, Britton, WJ & Chan, H-K 2022, 'Pharmacokinetics and safety of inhaled ivermectin in mice as a potential COVID-19 treatment', International Journal of Pharmaceutics, vol. 619, pp. 121688-121688. Alderdice, R, Hume, BCC, Kühl, M, Pernice, M, Suggett, DJ & Voolstra, CR 2022, 'Disparate Inventories of Hypoxia Gene Sets Across Corals Align With Inferred Environmental Resilience', Frontiers in Marine Science, vol. 9, pp. 1-14. Alderdice, R, Perna, G, Cárdenas, A, Hume, BCC, Wolf, M, Kühl, M, Pernice, M, Suggett, DJ & Voolstra, CR 2022, 'Deoxygenation lowers the thermal threshold of coral bleaching', Scientific Reports, vol. 12, no. 1, pp. 1-14. Alderdice, R, Pernice, M, Cárdenas, A, Hughes, DJ, Harrison, PL, Boulotte, N, Chartrand, K, Kühl, M, Suggett, DJ & Voolstra, CR 2022, 'Hypoxia as a physiological cue and pathological stress for coral larvae', Molecular Ecology, vol. 31, no. 2, pp. 571-587. Alghalayini, A, Cranfield, CG, Cornell, BA & Valenzuela, SM 2022, 'Preparing Ion Channel Switch Membrane-Based Biosensors', Methods in Molecular Biology, vol. 2402, pp. 13-20. Monitoring the changes in membrane conductance using electrical impedance spectroscopy is the platform of membrane-based biosensors in order to detect a specific target molecule. These biosensors represent the amalgamation of an electrical conductor such as gold and a chemically tethered bilayer lipid membrane with specific incorporated ion channels such as gramicidin-A that is further functionalized with detector molecules of interest. Alharbi, KS, Afzal, O, almalki, WH, Kazmi, I, Javed Shaikh, MA, Thangavelu, L, Gulati, M, Singh, SK, Jha, NK, Gupta, PK, Chellappan, DK, Oliver, BG, Dua, K & Gupta, G 2022, 'Nuclear factor-kappa B (NF-κB) inhibition as a therapeutic target for plant nutraceuticals in mitigating inflammatory lung diseases', Chemico-Biological Interactions, vol. 354, pp. 109842-109842. Alharbi, KS, Shaikh, MAJ, Almalki, WH, Kazmi, I, Al-Abbasi, FA, Alzarea, SI, Imam, SS, Alshehri, S, Ghoneim, MM, Singh, SK, Chellappan, DK, Oliver, BG, Dua, K & Gupta, G 2022, 'PI3K/Akt/mTOR Pathways Inhibitors with Potential Prospects in Non-Small-Cell Lung Cancer', Journal of Environmental Pathology, Toxicology and Oncology, vol. 41, no. 4, pp. 85-102. Lung cancer is the leading cause of cancer-related mortality across the globe. The most prevalent pathological form of lung cancer is non-small-cell lung cancer (NSCLC). Elevated stimulation of the PI3K/Akt/mTOR pathway causes a slew of cancer-related symptoms, making it a promising target for new anticancer drugs. The PI3K/Akt/mTOR path is involved extensively in carcinogenesis and disease advancement in NSCLC. Several new inhibitors targeting this pathway have been discovered in preclinical investigations and clinical trials. The etiology and epidemiology of NSCLC and biology of the PI3K/Akt/mTOR cascade and its role in NSCLC pathogenesis have all been discussed in this article. In this article, we've reviewed PI3K/Akt/mTOR cascade inhibitors that have been proven in vitro and in preclinical trials to be effective in NSCLC. Drugs targeting the PI3K/Akt/mTOR path in the treatment of NSCLC were also addressed. A better knowledge of the underlying molecular biology, including epigenetic changes, is also critical to detecting relevant biomarkers and guiding combination methods. Additionally, improved clinical trial designs will increase the capacity to test novel drugs and combinations for accounting for genomic variation and eventually improve patient outcomes. Ali, S, Jameel, MA, Gupta, A, Shafiei, M & Langford, SJ 2022, 'A room temperature functioning ammonia sensor utilising a bis-phenylalanine naphthalene diimide', Sensors and Actuators A: Physical, vol. 348, pp. 114008-114008. Ali, S, Jameel, MA, Harrison, CJ, Gupta, A, Shafiei, M & Langford, SJ 2022, 'Nanoporous naphthalene diimide surface enhances humidity and ammonia sensing at room temperature', Sensors and Actuators B: Chemical, vol. 351, pp. 130972-130972. Ali, SMN, Hossain, MJ, Wang, D, Mahmud, MAP, Sharma, V, Kashif, M & Kouzani, AZ 2022, 'Thermally degraded speed estimation of traction machine drive in electric vehicle', IET Electric Power Applications, vol. 16, no. 12, pp. 1464-1475. Allam, VSRR, Chellappan, DK, Jha, NK, Shastri, MD, Gupta, G, Shukla, SD, Singh, SK, Sunkara, K, Chitranshi, N, Gupta, V, Wich, PR, MacLoughlin, R, Oliver, BGG, Wernersson, S, Pejler, G & Dua, K 2022, 'Treatment of chronic airway diseases using nutraceuticals: Mechanistic insight', Critical Reviews in Food Science and Nutrition, vol. 62, no. 27, pp. 7576-7590. Respiratory diseases, both acute and chronic, are reported to be the leading cause of morbidity and mortality, affecting millions of people globally, leading to high socio-economic burden for the society in the recent decades. Chronic inflammation and decline in lung function are the common symptoms of respiratory diseases. The current treatment strategies revolve around using appropriate anti-inflammatory agents and bronchodilators. A range of anti-inflammatory agents and bronchodilators are currently available in the market; however, the usage of such medications is limited due to the potential for various adverse effects. To cope with this issue, researchers have been exploring various novel, alternative therapeutic strategies that are safe and effective to treat respiratory diseases. Several studies have been reported on the possible links between food and food-derived products in combating various chronic inflammatory diseases. Nutraceuticals are examples of such food-derived products which are gaining much interest in terms of its usage for the well-being and better human health. As a consequence, intensive research is currently aimed at identifying novel nutraceuticals, and there is an emerging notion that nutraceuticals can have a positive impact in various respiratory diseases. In this review, we discuss the efficacy of nutraceuticals in altering the various cellular and molecular mechanisms involved in mitigating the symptoms of respiratory diseases. Allam, VSRR, Paudel, KR, Gupta, G, Singh, SK, Vishwas, S, Gulati, M, Gupta, S, Chaitanya, MVNL, Jha, NK, Gupta, PK, Patel, VK, Liu, G, Kamal, MA, Hansbro, PM, Oliver, BGG, Chellappan, DK & Dua, K 2022, 'Nutraceuticals and mitochondrial oxidative stress: bridging the gap in the management of bronchial asthma', Environmental Science and Pollution Research, vol. 29, no. 42, pp. 62733-62754. Allan, SJ, O'Connell, MJ, Harasti, D, Klanten, OS & Booth, DJ 2022, 'Searching for seadragons: predicting micro‐habitat use for the common (weedy) seadragon (Phyllopteryx taeniolatus) based on habitat and prey', Journal of Fish Biology, vol. 100, no. 4, pp. 935-943. Allan, SJ, O'Connell, MJ, Harasti, D, Klanten, OS & Booth, DJ 2022, 'Space use by the endemic common (weedy) seadragon (Phyllopteryx taeniolatus): influence of habitat and prey', Journal of Fish Biology, vol. 100, no. 1, pp. 175-183. Allison, MC, Wurmehl, S, Büchner, B, Vella, JL, Söhnel, T, Bräuninger, SA, Klauss, H-H, Avdeev, M, Marlton, FP, Schmid, S & Ling, CD 2022, 'FeMn3Ge2Sn7O16: A Perfectly Isotropic 2-D Kagomé Lattice that Breaks Magnetic Symmetry with Partial Spin Order', Chemistry of Materials, vol. 34, no. 3, pp. 1369-1375. Alonzo, M, Alder, R, Clancy, L & Fu, S 2022, 'Portable testing techniques for the analysis of drug materials', WIREs Forensic Science, vol. 4, no. 6. Alquethamy, S, Ganio, K, Luo, Z, Hossain, SI, Hayes, AJ, Ve, T, Davies, MR, Deplazes, E, Kobe, B & McDevitt, CA 2022, 'Structural and biochemical characterization of Acinetobacter baumannii ZnuA', Journal of Inorganic Biochemistry, vol. 231, pp. 111787-111787. Alsarraf, HMAB, Ung, KL, Johansen, MD, Dimon, J, Olieric, V, Kremer, L & Blaise, M 2022, 'Biochemical, structural, and functional studies reveal that MAB_4324c from Mycobacterium abscessus is an active tandem repeat N‐acetyltransferase', FEBS Letters, vol. 596, no. 12, pp. 1516-1532. Alves, FM, Kysenius, K, Caldow, MK, Hardee, JP, Chung, JD, Trieu, J, Hare, DJ, Crouch, PJ, Ayton, S, Bush, AI, Lynch, GS & Koopman, R 2022, 'Iron overload and impaired iron handling contribute to the dystrophic pathology in models of Duchenne muscular dystrophy', Journal of Cachexia, Sarcopenia and Muscle, vol. 13, no. 3, pp. 1541-1553. Ambrose, SJ, Hamidian, M & Hall, RM 2022, 'Extensively resistant Acinetobacter baumannii isolate RCH52 carries several resistance genes derived from an IncC plasmid', Journal of Antimicrobial Chemotherapy, vol. 77, no. 4, pp. 930-933. Angeloski, A, Price, JR, Ennis, C, Smith, K, McDonagh, AM, Dowd, A, Thomas, P, Cortie, M, Appadoo, D & Bhadbhade, M 2022, 'Thermosalience Revealed on the Atomic Scale: Rapid Synchrotron Techniques Uncover Molecular Motion Preceding Crystal Jumping', Crystal Growth & Design, vol. 22, no. 3, pp. 1951-1959. The solid-state phase transformation in nickel(II) bis(diisopropyldithiocarbonate) is analyzed using a combination of high-speed in situ single-crystal diffraction, terahertz spectroscopy, optical microscopy, thermal analysis, and density functional theory. We show that the monoclinic P21/c structure of this compound undergoes a displacive phase change at about 3 °C. The monoclinic angles and unit cell volumes change reversibly between 110.3°/2265 Å3 and 103.8°/2168 Å3. An analysis of atomic positions using high-resolution in situ synchrotron X-ray diffraction data revealed details of the atomic displacements that show a change in order that precedes and accompanies the change in structure. The structural changes are rapid and are manifested as reversible macroscale crystal movement and jumping (thermosalience) and represent the first case of thermosalience in dithiocarbamate complexes. Archer, NS, Bluff, A, Eddy, A, Nikhil, CK, Hazell, N, Frank, D & Johnston, A 2022, 'Odour enhances the sense of presence in a virtual reality environment', PLOS ONE, vol. 17, no. 3, pp. e0265039-e0265039. Armstrong, E, Rai, T, Hersh, D, Thompson, S, Coffin, J, Ciccone, N, Flicker, L, Cadilhac, D, Godecke, E, Woods, D, Hayward, C, Hankey, GJ, McAllister, M & Katzenellenbogen, J 2022, 'Statistical analysis plan for the stepped wedge clinical trial Healing Right Way—enhancing rehabilitation services for Aboriginal Australians after brain injury', Trials, vol. 23, no. 1, p. 886. Arora, P, Nainwal, LM, Gupta, G, Singh, SK, Chellappan, DK, Oliver, BG & Dua, K 2022, 'Orally administered solasodine, a steroidal glycoalkaloid, suppresses ovalbumin-induced exaggerated Th2-immune response in rat model of bronchial asthma', Chemico-Biological Interactions, vol. 366, pp. 110138-110138. Asfour, L, Smyth, D, Whitchurch, CB, Cavaliere, R & Roland, JT 2022, 'Fluorescence in situ hybridization and microbial community profiling analysis of explanted cochlear implants', Acta Oto-Laryngologica, vol. 142, no. 5, pp. 395-401. Ashhurst, AS, Johansen, MD, Maxwell, JWC, Stockdale, S, Ashley, CL, Aggarwal, A, Siddiquee, R, Miemczyk, S, Nguyen, DH, Mackay, JP, Counoupas, C, Byrne, SN, Turville, S, Steain, M, Triccas, JA, Hansbro, PM, Payne, RJ & Britton, WJ 2022, 'Mucosal TLR2-activating protein-based vaccination induces potent pulmonary immunity and protection against SARS-CoV-2 in mice', Nature Communications, vol. 13, no. 1, p. 6972. Ashique, S, De Rubis, G, Sirohi, E, Mishra, N, Rihan, M, Garg, A, Reyes, R-J, Manandhar, B, Bhatt, S, Jha, NK, Singh, TG, Gupta, G, Singh, SK, Chellappan, DK, Paudel, KR, Hansbro, PM, Oliver, BG & Dua, K 2022, 'Short Chain Fatty Acids: Fundamental mediators of the gut-lung axis and their involvement in pulmonary diseases', Chemico-Biological Interactions, vol. 368, pp. 110231-110231. Ashourloo, D, Nematollahi, H, Huete, A, Aghighi, H, Azadbakht, M, Shahrabi, HS & Goodarzdashti, S 2022, 'A new phenology-based method for mapping wheat and barley using time-series of Sentinel-2 images', Remote Sensing of Environment, vol. 280, pp. 113206-113206. In recent years, various techniques have been developed to generate crop-type maps based on remote sensing data. Wheat and barley are two major cereal crops cultivated as the first and fourth largest grain crops across the globe. The variations in spectral temporal profile of both crops are generally insignificant at small scales and therefore the two crops are phenologically fairly clearly separated; however, at large scale areas the variance of phenological parameters increases for both crops due to the effects of various climatic and orographic factors which adversely influences discrimination of wheat and barley. Additionally, wheat and barley are usually cultivated as both spring and winter or early and late season crops in some areas, making it more difficult to distinguish them. Therefore, developing a new method based on remote sensing data for effective discrimination of wheat and barley is an important necessity in the field of precision agriculture. To this end, this research presents a new phenology-based method to discriminate barley from wheat. In this study, Sentinel-2 (S2) time-series data of a study site in Iran (Markazi) and two sites in the USA (Idaho and North California), are employed. Spectral reflectance values of wheat and barley are examined during the growing season and a new spectral-temporal feature is successfully developed for automatic identification of the barley heading date. The Relief-f algorithm is then employed to select appropriate spectral features of S2 to distinguish wheat from barley at the heading date. Finally, generated spectral features at the heading date are used as input to Support Vector Machine (SVM) and Random Forest (RF) to produce barley and wheat maps. The Kappa coefficient and overall accuracy (OA) obtained for the three study sites are more than 0.67 and 76%, respectively. The findings of this study demonstrate the potential of remote sensing data to identify the phenological growth stages of barl... Asrani, P, Tiwari, K, Eapen, MS, McAlinden, KD, Haug, G, Johansen, MD, Hansbro, PM, Flanagan, KL, Hassan, MI & Sohal, SS 2022, 'Clinical features and mechanistic insights into drug repurposing for combating COVID-19', The International Journal of Biochemistry & Cell Biology, vol. 142, pp. 106114-106114. Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) emerged from Wuhan in China before it spread to the entire globe. It causes coronavirus disease of 2019 (COVID-19) where mostly individuals present mild symptoms, some remain asymptomatic and some show severe lung inflammation and pneumonia in the host through the induction of a marked inflammatory 'cytokine storm'. New and efficacious vaccines have been developed and put into clinical practice in record time, however, there is a still a need for effective treatments for those who are not vaccinated or remain susceptible to emerging SARS-CoV-2 variant strains. Despite this, effective therapeutic interventions against COVID-19 remain elusive. Here, we have reviewed potential drugs for COVID-19 classified on the basis of their mode of action. The mechanisms of action of each are discussed in detail to highlight the therapeutic targets that may help in reducing the global pandemic. The review was done up to July 2021 and the data was assessed through the official websites of WHO and CDC for collecting the information on the clinical trials. Moreover, the recent research papers were also assessed for the relevant data. The search was mainly based on keywords like Coronavirus, SARS-CoV-2, drugs (specific name of the drugs), COVID-19, clinical efficiency, safety profile, side-effects etc.This review outlines potential areas for future research into COVID-19 treatment strategies. Assadi, MHN, Fronzi, M & Hanaor, DAH 2022, 'Unusual ferrimagnetic ground state in rhenium ferrite', The European Physical Journal Plus, vol. 137, no. 1. Augustine, R, S, A, Nayeem, A, Salam, SA, Augustine, P, Dan, P, Maureira, P, Mraiche, F, Gentile, C, Hansbro, PM, McClements, L & Hasan, A 2022, 'Increased complications of COVID-19 in people with cardiovascular disease: Role of the renin–angiotensin-aldosterone system (RAAS) dysregulation', Chemico-Biological Interactions, vol. 351, pp. 109738-109738. The rapid spread of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) that causes coronavirus disease 2019 (COVID-19), has had a dramatic negative impact on public health and economies worldwide. Recent studies on COVID-19 complications and mortality rates suggest that there is a higher prevalence in cardiovascular diseases (CVD) patients. Past investigations on the associations between pre-existing CVDs and susceptibility to coronavirus infections including SARS-CoV and the Middle East Respiratory Syndrome coronavirus (MERS-CoV), have demonstrated similar results. However, the underlying mechanisms are poorly understood. This has impeded adequate risk stratification and treatment strategies for CVD patients with SARS-CoV-2 infections. Generally, dysregulation of the expression of angiotensin-converting enzyme (ACE) and the counter regulator, angiotensin-converting enzyme 2 (ACE2) is a hallmark of cardiovascular risk and CVD. ACE2 is the main host receptor for SARS-CoV-2. Although further studies are required, dysfunction of ACE2 after virus binding and dysregulation of the renin-angiotensin-aldosterone system (RAAS) signaling may worsen the outcomes of people affected by COVID-19 and with preexisting CVD. Here, we review the current knowledge and outline the gaps related to the relationship between CVD and COVID-19 with a focus on the RAAS. Improved understanding of the mechanisms regulating viral entry and the role RAAS may direct future research with the potential to improve the prevention and management of COVID-19. Bai, L, Song, A, Lei, X, Zhang, T, Song, S, Tian, H, Liu, H, Qin, X, Wang, G & Shao, G 2022, 'Hierarchical construction of hollow NiCo2S4 nanotube@NiCo2S4 nanosheet arrays on Ni foam as an efficient and durable electrocatalyst for hydrogen evolution reaction', International Journal of Hydrogen Energy, vol. 47, no. 91, pp. 38524-38532. Ternary transition metal chalcogenide (TTMC) with multicomponent, different phases and unique electronic structures have been studied in electrocatalytic hydrogen evolution reaction (HER). However, the strong interaction between adsorbed H (H∗) and sulfur leads to the unfavorable hydrogen desorption properties of considerable TTMC. Herein, we constructed the hierarchical hollow NiCo2S4 nanotube@NiCo2S4 nanosheet arrays on Ni foam substrate (NT-NiCo2S4@NS-NiCo2S4/NF) by ion-exchange method. Homogeneous anion diffusion facilitates the formation of regular ultrathin nanosheets on hollow NiCo2S4 nanotube arrays, which presents hierarchical architecture with more surface area and channels to active site exposure, electrolyte diffusion, and gas desorption for HER. As-synthesized optimal NT-NiCo2S4@NS-NiCo2S4/NF electrode demonstrates an excellent HER activity, especially an overpotential of 221 mV, a Tafel slope of 108 mV dec−1, and remarkable stability at current densities of 100 mA cm−2 in 1.0 M NaOH electrolyte. Bai, X, Chen, H & Oliver, BG 2022, 'miRNAs-mediated overexpression of Periostin is correlated with poor prognosis and immune infiltration in lung squamous cell carcinoma', Aging, vol. 14, no. 9, pp. 3757-3781. Lung cancer is one of the most common malignancies with a high mortality rate worldwide. POSTN has been shown to be strongly correlated with the poor prognosis of lung cancer patients. However, the function and mechanism of action of POSTN in lung cancer remain unclear. Here, we carried out a pan-cancer analysis to assess the clinical prognostic value of POSTN based on the TCGA, TIMER, Oncomine, Kaplan-Meier, and UALCAN databases. We found that upregulated POSTN can be a promising biomarker to predict the prognosis of patients with lung cancer. High levels of POSTN correlated with immune cell infiltration in lung cancer, especially lung squamous cell carcinoma (LUSC), which was further confirmed based on the results from the TISIDB database. Moreover, the expression analysis, correlation analysis, and survival analysis revealed that POSTN-targeted miRNAs, downregulation of has-miR-144-3p and has-miR-30e-3p, were significantly linked to poor prognosis in patients with LUSC. Taken together, we identified that POSTN can act as a novel biomarker for determining the prognosis related to immune infiltration in patients with LUSC and deserves further research. Bai, X, Chen, H & Oliver, BG 2022, 'The health effects of traffic-related air pollution: A review focused the health effects of going green', Chemosphere, vol. 289, pp. 133082-133082. Bake, A, Rahman, MR, Evans, PJ, Cortie, M, Nancarrow, M, Abrudan, R, Radu, F, Khaydukov, Y, Causer, G, Livesey, KL, Callori, S, Mitchell, DRG, Pastuovic, Z, Wang, X & Cortie, D 2022, 'Ultra-small cobalt particles embedded in titania by ion beam synthesis: Additional datasets including electron microscopy, neutron reflectometry, modelling outputs and particle size analysis', Data in Brief, vol. 40, pp. 107674-107674. Barolo, L, Commault, AS, Abbriano, RM, Padula, MP, Kim, M, Kuzhiumparambil, U, Ralph, PJ & Pernice, M 2022, 'Unassembled cell wall proteins form aggregates in the extracellular space of Chlamydomonas reinhardtii strain UVM4', Applied Microbiology and Biotechnology, vol. 106, no. 11, pp. 4145-4156. Barone-Adesi, G, Platen, E & Sala, C 2022, 'Managing the Shortfall Risk of Target Date Funds by Overfunding', Swiss Finance Institute Research Paper, no. 20. Becchi, S, Hood, J, Kendig, MD, Mohammadkhani, A, Shipman, ML, Balleine, BW, Borgland, SL & Corbit, LH 2022, 'Food for thought: diet-induced impairments to decision-making and amelioration by N-acetylcysteine in male rats', Psychopharmacology, vol. 239, no. 11, pp. 3495-3506. RATIONALE: Attempts to lose weight often fail despite knowledge of the health risks associated with obesity and determined efforts. We previously showed that rodents fed an obesogenic diet displayed premature habitual behavioural control and weakened flexible decision-making based on the current value of outcomes produced by their behaviour. Thus, habitual control may contribute to failed attempts to modify eating behaviours. OBJECTIVES: To examine the effects of an obesogenic diet on behavioural control and glutamate transmission in dorsal striatum regions and to assess the ability of N-acetylcysteine (NAC) to reverse deficits. METHODS: Here, we examined diet-induced changes to decision-making and used in vitro electrophysiology to investigate the effects of diet on glutamate transmission within the dorsomedial (DMS) and dorsolateral (DLS) striatum, areas that control goal-directed and habitual behaviours, respectively. We administered NAC in order to normalize glutamate release and tested whether this would restore goal-directed performance following an obesogenic diet. RESULTS: We found that an obesogenic diet reduced sensitivity to outcome devaluation and increased glutamate release in the DMS, but not DLS. Administration of NAC restored goal-directed control and normalized mEPSCs in the DMS. Finally, NAC administered directly to the DMS was sufficient to reinstate sensitivity to outcome devaluation following an obesogenic diet. CONCLUSIONS: These data indicate that obesogenic diets alter neural activity in the basal ganglia circuit responsible for goal-directed learning and control which leads to premature habitual control. While the effects of diet are numerous and widespread, normalization of glutamatergic activity in this circuit is sufficient for restoring goal-directed behaviour. Belay, Y, Muller, A & Williams, DBG 2022, 'Lanthanum-1,2,3-Triazole-Based 2D Coordination Polymer is an Efficient Catalyst for the Oxidation of Olefins', Inorganic Chemistry, vol. 61, no. 21, pp. 8226-8232. Bell, KJ, Saad, S, Tillett, BJ, McGuire, HM, Bordbar, S, Yap, YA, Nguyen, LT, Wilkins, MR, Corley, S, Brodie, S, Duong, S, Wright, CJ, Twigg, S, de St Groth, BF, Harrison, LC, Mackay, CR, Gurzov, EN, Hamilton-Williams, EE & Mariño, E 2022, 'Metabolite-based dietary supplementation in human type 1 diabetes is associated with microbiota and immune modulation', Microbiome, vol. 10, no. 1. Bendall, ER, Bedward, M, Boer, M, Clarke, H, Collins, L, Leigh, A & Bradstock, RA 2022, 'Changes in the resilience of resprouting juvenile tree populations in temperate forests due to coupled severe drought and fire', Plant Ecology, vol. 223, no. 7, pp. 907-923. Bendall, ER, Bedward, M, Boer, M, Clarke, H, Collins, L, Leigh, A & Bradstock, RA 2022, 'Growth enhancements of elevated atmospheric [CO2] are reduced under drought‐like conditions in temperate eucalypts', Functional Ecology, vol. 36, no. 7, pp. 1542-1558. Bendall, ER, Bedward, M, Boer, M, Clarke, H, Collins, L, Leigh, A & Bradstock, RA 2022, 'Mortality and resprouting responses in forest trees driven more by tree and ecosystem characteristics than drought severity and fire frequency', Forest Ecology and Management, vol. 509, pp. 120070-120070. Bennett, B, Urzúa‐Encina, C, Pardo‐Roa, C, Ariyama, N, Lecocq, C, Rivera, C, Badía, C, Suárez, P, Agredo, M, Aguayo, C, Ávila, C, Araya, H, Pérez, P, Berrios, F, Agüero, B, Mendieta, V, Pituco, EM, de Almeida, IG, Medina, R, Brito, B, Johow, M & Ramirez, VN 2022, 'First report and genetic characterization of Seneca Valley virus (SVV) in Chile', Transboundary and Emerging Diseases, vol. 69, no. 6. Berdinsky, D, Elder, M & Kruengthomya, P 2022, 'Cayley polynomial–time computable groups', Information and Computation, vol. 288, pp. 104768-104768. Berdinsky, D, Elder, M & Taback, J 2022, 'On the geometry of Cayley automatic groups', International Journal of Algebra and Computation, vol. 32, no. 03, pp. 383-409. Beringer, J, Moore, CE, Cleverly, J, Campbell, DI, Cleugh, H, De Kauwe, MG, Kirschbaum, MUF, Griebel, A, Grover, S, Huete, A, Hutley, LB, Laubach, J, Van Niel, T, Arndt, SK, Bennett, AC, Cernusak, LA, Eamus, D, Ewenz, CM, Goodrich, JP, Jiang, M, Hinko‐Najera, N, Isaac, P, Hobeichi, S, Knauer, J, Koerber, GR, Liddell, M, Ma, X, Macfarlane, C, McHugh, ID, Medlyn, BE, Meyer, WS, Norton, AJ, Owens, J, Pitman, A, Pendall, E, Prober, SM, Ray, RL, Restrepo‐Coupe, N, Rifai, SW, Rowlings, D, Schipper, L, Silberstein, RP, Teckentrup, L, Thompson, SE, Ukkola, AM, Wall, A, Wang, Y, Wardlaw, TJ & Woodgate, W 2022, 'Bridge to the future: Important lessons from 20 years of ecosystem observations made by the OzFlux network', Global Change Biology, vol. 28, no. 11, pp. 3489-3514. Bernardini, A, Brown, J, Chipperfield, J, Bycroft, C, Chieppa, A, Cibella, N, Dunnet, G, Hawkes, MF, Hleihel, A, Law, EC, Ward, D & Zhang, L-C 2022, 'Evolution of the person census and the estimation of population counts in New Zealand, United Kingdom, Italy and Israel', Statistical Journal of the IAOS, vol. 38, no. 4, pp. 1221-1237. Bhat, AA, Gupta, G, Alharbi, KS, Afzal, O, Altamimi, ASA, Almalki, WH, Kazmi, I, Al-Abbasi, FA, Alzarea, SI, Chellappan, DK, Singh, SK, MacLoughlin, R, Oliver, BG & Dua, K 2022, 'Polysaccharide-Based Nanomedicines Targeting Lung Cancer', Pharmaceutics, vol. 14, no. 12, pp. 2788-2788. Bhattacharjee, R, Das, SS, Biswal, SS, Nath, A, Das, D, Basu, A, Malik, S, Kumar, L, Kar, S, Singh, SK, Upadhye, VJ, Iqbal, D, Almojam, S, Roychoudhury, S, Ojha, S, Ruokolainen, J, Jha, NK & Kesari, KK 2022, 'Mechanistic role of HPV-associated early proteins in cervical cancer: Molecular pathways and targeted therapeutic strategies', Critical Reviews in Oncology/Hematology, vol. 174, pp. 103675-103675. Bian, W, Wu, W, Wang, B, Tang, W, Zhou, M, Jin, C, Ding, H, Fan, W, Dong, Y, Li, J & Ding, D 2022, 'Revitalizing interface in protonic ceramic cells by acid etch', Nature, vol. 604, no. 7906, pp. 479-485. Bishop, A & Elder, M 2022, 'A virtually 2-step nilpotent group with polynomial geodesic growth', Algebra and Discrete Mathematics, vol. 33, no. 2, pp. 21-28. Bittleston, H, Hocking, JS, Goller, JL, Coombe, J, Bateson, D, Sweeney, S, Fleming, K & Huston, WM 2022, 'Is there a place for a molecular diagnostic test for pelvic inflammatory disease in primary care? An exploratory qualitative study', PLOS ONE, vol. 17, no. 9, pp. e0274666-e0274666. Blaskovich, MAT, Hansford, KA, Butler, MS, Ramu, S, Kavanagh, AM, Jarrad, AM, Prasetyoputri, A, Pitt, ME, Huang, JX, Lindahl, F, Ziora, ZM, Bradford, T, Muldoon, C, Rajaratnam, P, Pelingon, R, Edwards, DJ, Zhang, B, Amado, M, Elliott, AG, Zuegg, J, Coin, L, Woischnig, A-K, Khanna, N, Breidenstein, E, Stincone, A, Mason, C, Khan, N, Cho, H-K, Karau, MJ, Greenwood-Quaintance, KE, Patel, R, Wootton, M, James, ML, Hutton, ML, Lyras, D, Ogunniyi, AD, Mahdi, LK, Trott, DJ, Wu, X, Niles, S, Lewis, K, Smith, JR, Barber, KE, Yim, J, Rice, SA, Rybak, MJ, Ishmael, CR, Hori, KR, Bernthal, NM, Francis, KP, Roberts, JA, Paterson, DL & Cooper, MA 2022, 'A lipoglycopeptide antibiotic for Gram-positive biofilm-related infections', Science Translational Medicine, vol. 14, no. 662. Bohaud, C, Johansen, MD, Varga, B, Contreras-Lopez, R, Barthelaix, A, Hamela, C, Sapède, D, Cloitre, T, Gergely, C, Jorgensen, C, Kremer, L & Djouad, F 2022, 'Exploring Macrophage-Dependent Wound Regeneration During Mycobacterial Infection in Zebrafish', Frontiers in Immunology, vol. 13, pp. 1-16. Bordhan, P, Razavi Bazaz, S, Jin, D & Ebrahimi Warkiani, M 2022, 'Advances and enabling technologies for phase-specific cell cycle synchronisation', Lab on a Chip, vol. 22, no. 3, pp. 445-462. Bossley, MI, Steiner, A, Parra, GJ, Saltré, F & Peters, KJ 2022, 'Dredging activity in a highly urbanised estuary did not affect the long-term occurrence of Indo-Pacific bottlenose dolphins and long-nosed fur seals', Marine Pollution Bulletin, vol. 184, pp. 114183-114183. Boyton, I, Goodchild, SC, Diaz, D, Elbourne, A, Collins-Praino, LE & Care, A 2022, 'Characterizing the Dynamic Disassembly/Reassembly Mechanisms of Encapsulin Protein Nanocages', ACS Omega, vol. 7, no. 1, pp. 823-836. Brace, A, Gellert, K & Schlögl, E 2022, 'SOFR Term Structure Dynamics - Discontinuous Short Rates and Stochastic Volatility Forward Rates'. Bradbury, P, Cidem, A, Mahmodi, H, Davies, JM, Spicer, PT, Prescott, SW, Kabakova, I, Ong, HX & Traini, D 2022, 'Timothy Grass Pollen Induces Spatial Reorganisation of F-Actin and Loss of Junctional Integrity in Respiratory Cells', Inflammation, vol. 45, no. 3, pp. 1209-1223. Grass pollens have been identified as mediators of respiratory distress, capable of exacerbating respiratory diseases including epidemic thunderstorm asthma (ETSA). It is hypothesised that during thunderstorms, grass pollen grains swell to absorb atmospheric water, rupture, and release internal protein content to the atmosphere. The inhalation of atmospheric grass pollen proteins results in deadly ETSA events. We sought to identify the underlying cellular mechanisms that may contribute towards the severity of ETSA in temperate climates using Timothy grass (Phleum pratense). Respiratory cells exposed to Timothy grass pollen protein extract (PPE) caused cells to undergo hypoxia ultimately triggering the subcellular re-organisation of F-actin from the peri junctional belt to cytoplasmic fibre assembly traversing the cell body. This change in actin configuration coincided with the spatial reorganisation of microtubules and importantly, decreased cell compressibility specifically at the cell centre. Further to this, we find that the pollen-induced reorganisation of the actin cytoskeleton prompting secretion of the pro-inflammatory cytokine, interleukin-8. In addition, the loss of peri-junctional actin following exposure to pollen proteins was accompanied by the release of epithelial transmembrane protein, E-cadherin from cell-cell junctions resulting in a decrease in epithelial barrier integrity. We demonstrate that Timothy grass pollen regulates F-actin dynamics and E-cadherin localisation in respiratory cells to mediate cell-cell junctional integrity highlighting a possible molecular pathway underpinning ETSA events. Brito, BP, Koong, J, Wozniak, A, Opazo-Capurro, A, To, J, Garcia, P & Hamidian, M 2022, 'Genomic Analysis of Carbapenem-Resistant Acinetobacter baumannii Strains Recovered from Chilean Hospitals Reveals Lineages Specific to South America and Multiple Routes for Acquisition of Antibiotic Resistance Genes', Microbiology Spectrum, vol. 10, no. 5, p. e0246322. Broome, ST, Musumeci, G & Castorina, A 2022, 'PACAP and VIP Mitigate Rotenone-Induced Inflammation in BV-2 Microglial Cells', Journal of Molecular Neuroscience, vol. 72, no. 11, pp. 2163-2175. Brunet, M, Le Duff, N, Barbeyron, T & Thomas, F 2022, 'Consuming fresh macroalgae induces specific catabolic pathways, stress reactions and Type IX secretion in marine flavobacterial pioneer degraders', The ISME Journal, vol. 16, no. 8, pp. 2027-2039. Buchanan, CJ, Gaunt, B, Harrison, PJ, Yang, Y, Liu, J, Khan, A, Giltrap, AM, Le Bas, A, Ward, PN, Gupta, K, Dumoux, M, Tan, TK, Schimaski, L, Daga, S, Picchiotti, N, Baldassarri, M, Benetti, E, Fallerini, C, Fava, F, Giliberti, A, Koukos, PI, Davy, MJ, Lakshminarayanan, A, Xue, X, Papadakis, G, Deimel, LP, Casablancas-Antràs, V, Claridge, TDW, Bonvin, AMJJ, Sattentau, QJ, Furini, S, Gori, M, Huo, J, Owens, RJ, Schaffitzel, C, Berger, I, Renieri, A, Naismith, JH, Baldwin, AJ & Davis, BG 2022, 'Pathogen-sugar interactions revealed by universal saturation transfer analysis', Science, vol. 377, no. 6604. Budnik, G, Scott, JA, Jiao, C, Maazouz, M, Gledhill, G, Fu, L, Tan, HH & Toth, M 2022, 'Nanoscale 3D Tomography by In-Flight Fluorescence Spectroscopy of Atoms Sputtered by a Focused Ion Beam', Nano Letters, vol. 22, no. 20, pp. 8287-8293. Nanoscale fabrication and characterization techniques critically underpin a vast range of fields, including nanoelectronics and nanobiotechnology. Focused ion beam (FIB) techniques are appealing due to their high spatial resolution and widespread use for processing of nanostructured materials. Here, we introduce FIB-induced fluorescence spectroscopy (FIB-FS) as a nanoscale technique for spectroscopic detection of atoms sputtered by an ion beam. We use semiconductor heterostructures to demonstrate nanoscale lateral and depth resolution and show that it is limited by ion-induced intermixing of nanostructured materials. Sensitivity is demonstrated qualitatively by depth profiling of 3.5, 5, and 8 nm quantum wells and quantitatively by detection of trace-level impurities present at parts-per-million levels. The utility of the FIB-FS technique is demonstrated by characterization of quantum wells and Li-ion batteries. Our work introduces FIB-FS as a high-resolution, high-sensitivity, 3D analysis and tomography technique that combines the versatility of FIB nanofabrication techniques with the power of diffraction-unlimited fluorescence spectroscopy. Burmuzoska, I, Hogg, K, Raymond, J, Hitchcock, C & Meakin, GE 2022, 'Comparison of operational DNA recovery methods: Swabs versus tapelifts', Forensic Science International: Genetics Supplement Series, vol. 8, pp. 50-52. It is routine among many jurisdictions to recover DNA using tapelifts on porous substrates (e.g. clothing) and swabs on non-porous substrates (e.g. tool handles). Here, we examine this by comparing the efficiency of the NSW jurisdiction's specific swabbing and tapelift techniques on a range of porous and non-porous substrates. To test DNA recovery efficiency, 30 μl aliquots of 1:50 and 1:100 saliva dilutions were deposited onto the substrates, left to dry overnight, recovered, extracted, quantified and a subset profiled. Tapelifts recovered more DNA and DNA profiles with more detectable alleles than swabs for both saliva dilutions on porous substrates. For non-porous substrates, similar DNA quantities and profiles were generally recovered with both methods for both saliva dilutions. These data underpin current practices to recover DNA using tapelifts for porous substrates and swabs for non-porous substrates. These data also revealed severe degradation of DNA recovered from brass, supporting the on-going need to improve DNA recovery and analysis methods for brass substrates. Butt, N, Halpern, BS, O'Hara, CC, Allcock, AL, Polidoro, B, Sherman, S, Byrne, M, Birkeland, C, Dwyer, RG, Frazier, M, Woodworth, BK, Arango, CP, Kingsford, MJ, Udyawer, V, Hutchings, P, Scanes, E, McClaren, EJ, Maxwell, SM, Diaz‐Pulido, G, Dugan, E, Simmons, BA, Wenger, AS, Linardich, C & Klein, CJ 2022, 'A trait‐based framework for assessing the vulnerability of marine species to human impacts', Ecosphere, vol. 13, no. 2. Butterworth, NJ & Wallman, JF 2022, 'Flies getting filthy: The precopulatory mating behaviours of three mud‐dwelling species of Australian Lispe (Diptera: Muscidae)', Ethology, vol. 128, no. 4, pp. 369-377. Buzova, D, Braghini, MR, Bianco, SD, Lo Re, O, Raffaele, M, Frohlich, J, Kisheva, A, Crudele, A, Mosca, A, Sartorelli, MR, Balsano, C, Cerveny, J, Mazza, T, Alisi, A & Vinciguerra, M 2022, 'Profiling of cell‐free DNA methylation and histone signatures in pediatric NAFLD: A pilot study', Hepatology Communications, vol. 6, no. 12, pp. 3311-3323. Camaya, I, Donnelly, S & O'Brien, B 2022, 'Targeting the Camirand Lemyre, F, Carroll, RJ & Delaigle, A 2022, 'Semiparametric Estimation of the Distribution of Episodically Consumed Foods Measured With Error', Journal of the American Statistical Association, vol. 117, no. 537, pp. 469-481. © 2020 American Statistical Association. Dietary data collected from 24-hour dietary recalls are observed with significant measurement errors. In the nonparametric curve estimation literature, much of the effort has been devoted to designing methods that are consistent under contamination by noise, and which have been traditionally applied for analyzing those data. However, some foods such as alcohol or fruits are consumed only episodically, and may not be consumed during the day when the 24-hour recall is administered. These so-called excess zeros make existing nonparametric estimators break down, and new techniques need to be developed for such data. We develop two new consistent semiparametric estimators of the distribution of such episodically consumed food data, making parametric assumptions only on some less important parts of the model. We establish its theoretical properties and illustrate the good performance of our fully data-driven method in simulated and real data. Supplementary materials for this article are available online. Camp, EF 2022, 'Contingency planning for coral reefs in the Anthropocene; The potential of reef safe havens', Emerging Topics in Life Sciences, vol. 6, no. 1, pp. 107-124. Camp, EF, Kahlke, T, Signal, B, Oakley, CA, Lutz, A, Davy, SK, Suggett, DJ & Leggat, WP 2022, 'Proteome metabolome and transcriptome data for three Symbiodiniaceae under ambient and heat stress conditions', Scientific Data, vol. 9, no. 1, pp. 1-10. Camp, EF, Nitschke, MR, Clases, D, Gonzalez de Vega, R, Reich, HG, Goyen, S & Suggett, DJ 2022, 'Micronutrient content drives elementome variability amongst the Symbiodiniaceae', BMC Plant Biology, vol. 22, no. 1, pp. 1-14. Cao, H-L, Nguyen, HAD, Luu, TH, Vu, HTT, Pham, D, Vu, VTN, Le, HH, Nguyen, DXB, Truong, TT, Nguyen, H-D & Nguyen, C-N 2022, 'Localized automation solutions in response to the first wave of COVID-19: a story from Vietnam', International Journal of Pervasive Computing and Communications, vol. 18, no. 5, pp. 548-562. Cao, X, Huo, J, Li, L, Qu, J, Zhao, Y, Chen, W, Liu, C, Liu, H & Wang, G 2022, 'Recent Advances in Engineered Ru‐Based Electrocatalysts for the Hydrogen/Oxygen Conversion Reactions', Advanced Energy Materials, vol. 12, no. 41, pp. 2202119-2202119. Cao, Y, Xie, Z, Woodgate, W, Ma, X, Cleverly, J, Pang, Y, Qin, F & Huete, A 2022, 'Ecohydrological decoupling of water storage and vegetation attributed to China’s large-scale ecological restoration programs', Journal of Hydrology, vol. 615, pp. 128651-128651. China has implemented some of the world's most ambitious ecological restoration (ER) programs over the past two decades. These large-scale multi-billion-dollar projects have achieved widespread greening across the country. However, the impacts of different ER-driven land cover modifications on total water resources remain largely unknown, particularly over areas characterized by complex environments of coupled human and natural systems. Here we quantified ecohydrological impacts of multiple ER programs applied over various parts of China's Yellow River Basin (YRB), with their lumped effects being partitioned into individual ones. ER-related drivers were disentangled, leading in individual attribution of inter-annual climatic variability and agricultural activity with cross-sensor satellite observations and statistical modelling. Our results showed an ecohydrological decoupling of water storage and vegetation greenness attributed to ER programs. Increases in natural land cover types (e.g. forest and grassland) were found at the expense of human intensive land use, such as farmland, with the combined changes resulting in a concurrent dramatic water storage loss of 3.70 billion tons/year from 2002 to 2021. ER was the dominant driver of water loss (>66 %) among all factors considered, commensurate with areal land-cover change and ER program cost. The entire basin was divided into two regions with opposite water trends by the ER activities with different restoration strategies. This study's framework is applicable to substantial part of the globe like YRB and is encouraged to be applied for more wholistic ER impact evaluations. Cárdenas, A, Raina, J-B, Pogoreutz, C, Rädecker, N, Bougoure, J, Guagliardo, P, Pernice, M & Voolstra, CR 2022, 'Greater functional diversity and redundancy of coral endolithic microbiomes align with lower coral bleaching susceptibility', The ISME Journal, vol. 16, no. 10, pp. 2406-2420. Carter, DJ, Rahmani, A & Brown, JJ 2022, 'Regulating Health Care Safety: Enforcement and Responsibility Attribution in Response to Iatrogenic Harm', JOURNAL OF LAW AND MEDICINE, vol. 29, no. 3, pp. 847-865. Carter, DJ, Rahmani, A & Brown, JJ 2022, 'Regulating Health Care Safety: Enforcement and Responsibility Attribution in Response to Iatrogenic Harm.', J Law Med, vol. 29, no. 3, pp. 847-865. The regulation of health care safety is undertaken in the name of the public and is motivated and justified by their protection. This regulatory action generates debate concerning the proper limits of responsibility attribution and enforcement, while the actions and opinion - both imagined and real - of the public loom large in this field. However, there exists limited knowledge of public opinion on key aspects of health care safety enforcement and responsibility attribution following iatrogenic harm. This article reports on the results of a survey-administered experimental study to determine how the Australian general public attributes responsibility, moral censure and enforcement actions in the event of health care safety failures in hospital and outpatient settings. The study provide evidence that the general public are sensitive to corporate and individual sources of error; attribute responsibility in a pluralistic manner; differentiate between recklessness and negligence; and will attempt both formal and social enforcement actions in response to harm. Castorina, A, Mandwie, M, Piper, J, Gorrie, C, Keay, K, Musumeci, G & Al-Badri, G 2022, 'Rapid GFAP and Iba1 expression changes in the female rat brain following spinal cord injury', Neural Regeneration Research, vol. 17, no. 2, pp. 378-378. Spinal cord injury (SCI) is a devastating condition often associated with sleep disorders, mood change and depression. Evidence suggests that rapid changes to supporting glia may predispose individuals with SCI to such comorbidities. Here, we interrogated the expression of astrocyte- and microglial-specific markers glial fibrillary acidic protein (GFAP) and ionized calcium binding adaptor molecule 1 (Iba1) in the rat brain in the first 24 hours following spinal cord injury (SCI). Female Sprague Dawley rats underwent thoracic laminectomy; half of the rats received a mild contusion injury at the level of the T10 vertebral body (SCI group), the other half did not (Sham group). Twenty-four hours post-surgery the rats were sacrificed, and the amygdala, periaqueductal grey, prefrontal cortex, hypothalamus, lateral thalamus, hippocampus (dorsal and ventral) were collected. GFAP and Iba1 mRNA and protein levels were measured by real-time qPCR and Western blot. In SCI rats, GFAP mRNA and protein expression increased in the amygdala and hypothalamus (*p<0.05). In contrast, gene and protein expression decreased in the thalamus (**p<0.01) and dorsal hippocampus (*p<0.05 and **p<0.01, respectively). Interestingly, Iba1 transcripts and proteins were significantly diminished only in the dorsal (*p<0.05 and **p<0.01, respectively) and ventral hippocampus, where gene expression diminished (*p<0.05 for both mRNA and protein). Considered together, these findings demonstrate that as early as 24 hours post-SCI there are region-specific disruptions of GFAP and Iba1 transcript and protein levels in higher brain regions. Cawley, A, Keen, B, Tou, K, Elbourne, M & Keledjian, J 2022, 'Biomarker ratios', Drug Testing and Analysis, vol. 14, no. 5, pp. 983-990. Chakraborty, P, Das, SS, Dey, A, Chakraborty, A, Bhattacharyya, C, Kandimalla, R, Mukherjee, B, Gopalakrishnan, AV, Singh, SK, Kant, S, Nand, P, Ojha, S, Kumar, P, Jha, NK, Jha, SK & Dewanjee, S 2022, 'Corrigendum to “Quantum dots: The cutting-edge nanotheranostics in brain cancer management” [Journal of Controlled Release, Volume 350 (2022) Pages 698–715]', Journal of Controlled Release, vol. 352, pp. 459-459. Chakraborty, P, Das, SS, Dey, A, Chakraborty, A, Bhattacharyya, C, Kandimalla, R, Mukherjee, B, Gopalakrishnan, AV, Singh, SK, Kant, S, Nand, P, Ojha, S, Kumar, P, Jha, NK, Jha, SK & Dewanjee, S 2022, 'Quantum dots: The cutting-edge nanotheranostics in brain cancer management', Journal of Controlled Release, vol. 350, pp. 698-715. Chalmers, T, Hickey, BA, Newton, P, Lin, C-T, Sibbritt, D, McLachlan, CS, Clifton-Bligh, R, Morley, J & Lal, S 2022, 'Stress Watch: The Use of Heart Rate and Heart Rate Variability to Detect Stress: A Pilot Study Using Smart Watch Wearables', Sensors, vol. 22, no. 1, pp. 151-151. Chalmers, T, Hickey, BA, Newton, P, Lin, C-T, Sibbritt, D, McLachlan, CS, Clifton-Bligh, R, Morley, JW & Lal, S 2022, 'Associations between Sleep Quality and Heart Rate Variability: Implications for a Biological Model of Stress Detection Using Wearable Technology', International Journal of Environmental Research and Public Health, vol. 19, no. 9, pp. 5770-5770. Chan, LLY, Anderson, DE, Cheng, HS, Ivan, FX, Chen, S, Kang, AEZ, Foo, R, Gamage, AM, Tiew, PY, Koh, MS, Lee, KCH, Nichol, K, Pathinayake, PS, Chan, YL, Yeo, TW, Oliver, BG, Wark, PAB, Liu, L, Tan, NS, Wang, L-F & Chotirmall, SH 2022, 'The establishment of COPD organoids to study host-pathogen interaction reveals enhanced viral fitness of SARS-CoV-2 in bronchi', Nature Communications, vol. 13, no. 1, p. 7635. Chan, Y, Singh, SK, Gulati, M, Wadhwa, S, Prasher, P, Kumar, D, Kumar, AP, Gupta, G, Kuppusamy, G, Haghi, M, George Oliver, BG, Adams, J, Chellappan, DK & Dua, K 2022, 'Advances and applications of monoolein as a novel nanomaterial in mitigating chronic lung diseases', Journal of Drug Delivery Science and Technology, vol. 74, pp. 103541-103541. Chronic lung diseases such as asthma, chronic obstructive pulmonary disease, lung cancer, and the recently emerged COVID-19, are a huge threat to human health, and among the leading causes of global morbidity and mortality every year. Despite availability of various conventional therapeutics, many patients remain poorly controlled and have a poor quality of life. Furthermore, the treatment and diagnosis of these diseases are becoming increasingly challenging. In the recent years, the application of nanomedicine has become increasingly popular as a novel strategy for diagnosis, treatment, prevention, as well as follow-up of chronic lung diseases. This is attributed to the ability of nanoscale drug carriers to achieve targeted delivery of therapeutic moieties with specificity to diseased site within the lung, thereby enhancing therapeutic outcomes of conventional therapies whilst minimizing the risks of adverse reactions. For this instance, monoolein is a polar lipid nanomaterial best known for its versatility, thermodynamic stability, biocompatibility, and biodegradability. As such, it is commonly employed in liquid crystalline systems for various drug delivery applications. In this review, we present the applications of monoolein as a novel nanomaterial-based strategy for targeted drug delivery with the potential to revolutionize therapeutic approaches in chronic lung diseases. Charbe, NB, Castillo, F, Tambuwala, MM, Prasher, P, Chellappan, DK, Carreño, A, Satija, S, Singh, SK, Gulati, M, Dua, K, González-Aramundiz, JV & Zacconi, FC 2022, 'A new era in oxygen therapeutics? From perfluorocarbon systems to haemoglobin-based oxygen carriers', Blood Reviews, vol. 54, pp. 100927-100927. Charon, J, Kahlke, T, Larsson, ME, Abbriano, R, Commault, A, Burke, J, Ralph, P & Holmes, EC 2022, 'Diverse RNA Viruses Associated with Diatom, Eustigmatophyte, Dinoflagellate, and Rhodophyte Microalgae Cultures', Journal of Virology, vol. 96, no. 20, p. e0078322. Chau, CV, Sen, S, Sedgwick, AC, Gale, PA, Pantos, GD, Kim, SK, Park, JS, Tomat, E, Arambula, JF, Gorden, AEV & Furuta, H 2022, 'Solving world problems with pyrrole: 65th birthday tribute to Prof. Jonathan L. Sessler', Chem, vol. 8, no. 3, pp. 587-598. Che, S, Zhang, L, Wang, T, Su, D & Wang, C 2022, 'Graphitic Carbon Nitride‐Based Photocatalysts for Biological Applications', Advanced Sustainable Systems, vol. 6, no. 1, pp. 2100294-2100294. Che, S, Zhou, X, Zhang, L, Su, D, Wang, T & Wang, C 2022, 'Construction of a 2D Layered Phosphorus‐doped Graphitic Carbon Nitride/BiOBr Heterojunction for Highly Efficient Photocatalytic Disinfection', Chemistry – An Asian Journal, vol. 17, no. 11, p. e202200095. Chellappan, DK, Paudel, KR, Tan, NW, Cheong, KS, Khoo, SSQ, Seow, SM, Chellian, J, Candasamy, M, Patel, VK, Arora, P, Singh, PK, Singh, SK, Gupta, G, Oliver, BG, Hansbro, PM & Dua, K 2022, 'Targeting the mitochondria in chronic respiratory diseases', Mitochondrion, vol. 67, pp. 15-37. Chen, C, Ding, L, Liu, B, Du, Z, Liu, Y, Di, X, Shan, X, Lin, C, Zhang, M, Xu, X, Zhong, X, Wang, J, Chang, L, Halkon, B, Chen, X, Cheng, F & Wang, F 2022, 'Exploiting Dynamic Nonlinearity in Upconversion Nanoparticles for Super-Resolution Imaging', Nano Letters, vol. 22, no. 17, pp. 7136-7143. Single-beam super-resolution microscopy, also known as superlinear microscopy, exploits the nonlinear response of fluorescent probes in confocal microscopy. The technique requires no complex purpose-built system, light field modulation, or beam shaping. Here, we present a strategy to enhance this technique's spatial resolution by modulating excitation intensity during image acquisition. This modulation induces dynamic optical nonlinearity in upconversion nanoparticles (UCNPs), resulting in variations of nonlinear fluorescence response in the obtained images. The higher orders of fluorescence response can be extracted with a proposed weighted finite difference imaging algorithm from raw fluorescence images to generate an image with higher resolution than superlinear microscopy images. We apply this approach to resolve single nanoparticles in a large area, improving the resolution to 132 nm. This work suggests a new scope for the development of dynamic nonlinear fluorescent probes in super-resolution nanoscopy. Chen, D, Fröch, JE, Ru, S, Cai, H, Wang, N, Adamo, G, Scott, J, Li, F, Zheludev, N, Aharonovich, I & Gao, W 2022, 'Quantum Interference of Resonance Fluorescence from Germanium-Vacancy Color Centers in Diamond', Nano Letters, vol. 22, no. 15, pp. 6306-6312. Resonance fluorescence from a quantum emitter is an ideal source to extract indistinguishable photons. By using the cross-polarization to suppress the laser scattering, we observed resonance fluorescence from GeV color centers in diamond at cryogenic temperature. The Fourier-transform-limited line width emission with T2/2T1 ∼ 0.86 allows for two-photon interference based on single GeV color center. Under pulsed excitation, the separated photons exhibit a Hong-Ou-Mandel quantum interference above classical limit, whereas the continuous-wave excitation leads to a coalescence time window of 1.05 radiative lifetime. In addition, we demonstrated a single-shot readout of spin states with a fidelity of 74%. Our experiments lay down the foundation for building a quantum network with GeV color centers in diamond. Chen, H & van Reyk, D 2022, 'Reply to Duric', Advances in Physiology Education, vol. 46, no. 3, pp. 508-508. Chen, H, Aneman, I, Nikolic, V, Karadzov Orlic, N, Mikovic, Z, Stefanovic, M, Cakic, Z, Jovanovic, H, Town, SEL, Padula, MP & McClements, L 2022, 'Maternal plasma proteome profiling of biomarkers and pathogenic mechanisms of early-onset and late-onset preeclampsia', Scientific Reports, vol. 12, no. 1, p. 19099. Chen, H, Haddadi, N, Zhu, X, Hatoum, D, Chen, S, Nassif, NT, Lin, Y & McGowan, EM 2022, 'Expression Profile of Sphingosine Kinase 1 Isoforms in Human Cancer Tissues and Cells: Importance and Clinical Relevance of the Neglected 1b-Isoform', Journal of Oncology, vol. 2022, pp. 1-12. Chen, H, Kimyon, Ö, Ramandi, HL, Craig, P, Gunawan, C, Wu, S, Manefield, M, Crosky, A & Saydam, S 2022, 'Microbiologically influenced stress corrosion cracking responsible for catastrophic failure of cable bolts', Engineering Failure Analysis, vol. 131, pp. 105884-105884. In the past two decades, reports of the premature failure of cable bolts used in the mining and civil industries have been increasing. Previous studies have established that failure occurs through hydrogen-induced stress corrosion cracking (HISCC), which is a type of environmentally assisted hydrogen cracking. However, to date, the cause of HISCC has been unclear. For the first time, we studied the role of microorganisms in the failure of cable bolts using components present in SCC-affected mines. Stressed coupons were prepared from the cable bolt wires and tested in groundwater with additions of sulphate-reducing bacteria, coal, clay, pyrite and lactate. It was found that hydrogen sulphide (H2S) produced by sulphate- and sulphur-reducing bacteria promoted hydrogen diffusion into the steel and, in the presence of stress, caused HISCC. This suggests that control of H2S production should be a priority for mining and civil industries to avoid premature failure of anchoring systems. Chen, H, Oliver, BG, Pant, A, Olivera, A, Poronnik, P, Pollock, CA & Saad, S 2022, 'Effects of air pollution on human health – Mechanistic evidence suggested by in vitro and in vivo modelling', Environmental Research, vol. 212, pp. 113378-113378. Chen, H, Tesic, M, Nikolic, VN, Pavlovic, M, Vucic, RM, Spasic, A, Jovanovic, H, Jovanovic, I, Town, SEL, Padula, MP & McClements, L 2022, 'Systemic Biomarkers and Unique Pathways in Different Phenotypes of Heart Failure with Preserved Ejection Fraction', Biomolecules, vol. 12, no. 10, pp. 1419-1419. Chen, H, Van Reyk, D, Oliveira, A, Chan, YL, Town, SEL, Rayner, B, Pollock, CA, Saad, S, George, J, Padula, MP & Oliver, BG 2022, 'Sex-Dependent Responses to Maternal Exposure to PM2.5 in the Offspring', Antioxidants, vol. 11, no. 11, pp. 2255-2255. Chen, H, van Reyk, D, Reyna, J & Oliver, BG 2022, 'A comparison of attitudes toward remote learning during the COVID-19 pandemic between students attending a Chinese and an Australian campus', Advances in Physiology Education, vol. 46, no. 2, pp. 297-308. Chen, H, Yang, Y, Miyai, H, Yi, C & Oliver, BG 2022, 'The effects of exercise with nicotine replacement therapy for smoking cessation in adults: A systematic review', Frontiers in Psychiatry, vol. 13, p. 1053937. Chen, J, Xiao, J, Li, J, Gao, H, Guo, X, Liu, H & Wang, G 2022, 'Nano-engineering induced Bi dots in situ anchored into modified porous carbon with superior sodium ion storage', Journal of Materials Chemistry A, vol. 10, no. 38, pp. 20635-20645. Chen, J, Yao, B, Yang, Z, Shi, W, Luo, T, Xi, P, Jin, D & Li, Y 2022, 'Ratiometric 4Pi single-molecule localization with optimal resolution and color assignment', Optics Letters, vol. 47, no. 2, pp. 325-325. Chen, L, Wu, X, Gilchrist, AM & Gale, PA 2022, 'Organoplatinum Compounds as Anion‐Tuneable Uphill Hydroxide Transporters', Angewandte Chemie, vol. 134, no. 19. Chen, L, Wu, X, Gilchrist, AM & Gale, PA 2022, 'Organoplatinum Compounds as Anion‐Tuneable Uphill Hydroxide Transporters', Angewandte Chemie International Edition, vol. 61, no. 19, p. e202116355. Chen, X, Gu, Y, Chai, Y, Wu, N, Wen, C, Ke, J, Sun, Y, Li, F & Feng, W 2022, 'An Optical Multiplexing Method Using Upconversion Nanoparticles with Tunable P–I Relationship', Advanced Optical Materials, vol. 10, no. 22. Chen, Y, Shimoni, O, Huang, G, Wen, S, Liao, J, Duong, HTT, Maddahfar, M, Su, QP, Ortega, DG, Lu, Y, Campbell, DH, Walsh, BJ & Jin, D 2022, 'Upconversion nanoparticle‐assisted single‐molecule assay for detecting circulating antigens of aggressive prostate cancer', Cytometry Part A, vol. 101, no. 5, pp. 400-410. Cheng, GW-Y, Mok, KK-S, Yeung, SH-S, Kofler, J, Herrup, K & Tse, K-H 2022, 'Apolipoprotein E ε4 Mediates Myelin Breakdown by Targeting Oligodendrocytes in Sporadic Alzheimer Disease', Journal of Neuropathology & Experimental Neurology, vol. 81, no. 9, pp. 717-730. Cheng, J, Li, C, Ying, Y, Lv, J, Qu, X, McGowan, E, Lin, Y & Zhu, X 2022, 'Metformin Alleviates Endometriosis and Potentiates Endometrial Receptivity via Decreasing VEGF and MMP9 and Increasing Leukemia Inhibitor Factor and HOXA10', Frontiers in Pharmacology, vol. 13, p. 750208. Chong, H, Fang, S, Yang, D, Tan, C, Wei, J, Chang, S-H, Fan, H, Yao, H, Qin, A, Shao, H, Zhang, Y, Leng, J, Su, D, Wang, C & Li, H 2022, 'Toxicity assessments and transcriptional effects of monofunctionalized Pt(II) complex under dark and light irradiation condition in Caenorhabditis elegans', Journal of Inorganic Biochemistry, vol. 230, pp. 111720-111720. In vivo toxicity of aromatic ring (BODIPY, 1,3,5,7,8-pentamethyl dipyrrin borondifluoride) attached monofunctional Pt(II) complexes mCBP {[cis-Pt(NH3)2Cl] 8-(para-pyridine-methylene),1,3,5,7-tetramethyl dipyrrin borondifluoride}+ Nitrate- and dCBP {[cis-Pt(NH3)2Cl]28-(1,3-pyrimidine-5-methylene),1,3,5,7-tetramethyl dipyrrin borondifluoride}2+ diNitrate2- were tested in Caenorhabditis elegans (C. elegans). dCBP showed promising reactive oxygen ROS (reactive oxygen species) generating capability. This complex resulted reduction of lifespan, body length and egg laying rate under dark and light irradiation in both N2 (wild-type, cisplatin resistant) and ok938 (asna-1, cisplatin sensitive) C. elegans. Expressional change of several key cancer related pathway (JNK (c-Jun N-terminal kinase) and Wnt/β-catenin (Wingless/Integrated/β-catenin)) related genes (for instance, jnk-1, wrm-1 and gst-4) were confirmed by RNA sequencing experiments. These transcriptional alternations could explain physiological parameters change in nematode and partially revealed how both Pt(II) based complexes influence cancer related pathways. Furthermore, these associated genes exhibited the function of apoptosis, reduced chemoresistance of cancer cells and most of those expressional changes were linked to extended survival of cancer patients. Chotirmall, SH, Bogaert, D, Chalmers, JD, Cox, MJ, Hansbro, PM, Huang, YJ, Molyneaux, PL, O’Dwyer, DN, Pragman, AA, Rogers, GB, Segal, LN & Dickson, RP 2022, 'Therapeutic Targeting of the Respiratory Microbiome', American Journal of Respiratory and Critical Care Medicine, vol. 206, no. 5, pp. 535-544. Choucair, H, Rahman, MK, Umashankar, B, Al-Zubaidi, Y, Bourget, K, Chen, Y, Dunstan, C, Rawling, T & Murray, M 2022, 'The aryl-ureido fatty acid CTU activates endoplasmic reticulum stress and PERK/NOXA-mediated apoptosis in tumor cells by a dual mitochondrial-targeting mechanism', Cancer Letters, vol. 526, pp. 131-141. The cancer cell mitochondrion is functionally different from that in normal cells and could be targeted to develop novel experimental therapeutics. The aryl-ureido fatty acid CTU (16({[4-chloro-3-(trifluoromethyl)phenyl]-carbamoyl}amino)hexadecanoic acid) is the prototype of a new class of mitochondrion-targeted agents that kill cancer cells. Here we show that CTU rapidly depolarized the inner mitochondrial membrane, selectively inhibited complex III of the electron transport chain and increased reactive oxygen species (ROS) production. From RNA-seq analysis, endoplasmic reticulum (ER)-stress was a major activated pathway in CTU-treated cells and in MDA-MB-231 tumor xenografts from CTU-treated nu/nu mice. Mitochondrion-derived ROS activated the PERK-linked ER-stress pathway and induced the BH3-only protein NOXA leading to outer mitochondrial membrane (OMM) disruption. The lipid peroxyl scavenger α-tocopherol attenuated CTU-dependent ER-stress and apoptosis which confirmed the critical role of ROS. Oleic acid protected against CTU-mediated apoptosis by activating Mcl-1 expression, which increased NOXA sequestration and prevented OMM disruption. Taken together, CTU both uncouples mitochondrial electron transport and activates ROS production which promotes ER-stress-dependent OMM disruption and tumor cell death. Dual-mitochondrial targeting agents like CTU offer a novel approach for development of new anti-cancer therapeutics. Clark, SR, Pagendam, D & Ryan, L 2022, 'Forecasting Multiple Groundwater Time Series with Local and Global Deep Learning Networks', International Journal of Environmental Research and Public Health, vol. 19, no. 9, pp. 5091-5091. Clarke, H, Nolan, RH, De Dios, VR, Bradstock, R, Griebel, A, Khanal, S & Boer, MM 2022, 'Forest fire threatens global carbon sinks and population centres under rising atmospheric water demand', Nature Communications, vol. 13, no. 1, p. 7161. Colarusso, C, Terlizzi, M, Maglio, A, Molino, A, Candia, C, Vitale, C, Hansbro, PM, Vatrella, A, Pinto, A & Sorrentino, R 2022, 'Activation of the AIM2 Receptor in Circulating Cells of Post-COVID-19 Patients With Signs of Lung Fibrosis Is Associated With the Release of IL-1α, IFN-α and TGF-β', Frontiers in Immunology, vol. 13, p. 934264. Collins, S, Maestrini, L, Ueland, M & Stuart, B 2022, 'A preliminary investigation to determine the suitability of pigs as human analogues for post-mortem lipid analysis', Talanta Open, vol. 5, pp. 100100-100100. The determination of time since death is a major challenge to law enforcement when faced with the discovery of human remains. This is due to the fact that decomposition is a complex, dynamic process influenced by several abiotic and biotic factors. For decades, post-mortem decomposition studies have used pigs as human analogues due to ethical and legal restrictions surrounding the use of human cadavers for such research. However, few comparative studies have been conducted to assess the suitability of these analogues. Recent forensic studies have successfully demonstrated the use of post-mortem lipids in textiles as a method to obtain vital information about decomposition process. The current investigation involved two studies: Trial 1 (summer) and Trial 2 (winter). Each trial with n = 1 human cadaver and n = 2 pigs. Samples were collected over a timeline of 105 days post-placement and analyzed using attenuated total reflectance (ATR-) Fourier-transform infrared (FTIR) spectroscopy. The data was then statistically assessed using functional principal component analysis, semi-parametric regression modeling and analysis of variance. The results demonstrated a clear statistically significant interspecies difference between pigs and humans in both trials. The preliminary implications of this study suggest that pigs are not suitable analogues for humans in decomposition research and have broader implications that caution the direct translation of decomposition data obtained from pigs to real human casework, particularly with respect to time since death estimations. Coni, EOC, Booth, DJ & Nagelkerken, I 2022, 'Coral-reef fishes can become more risk-averse at their poleward range limits', Proceedings of the Royal Society B: Biological Sciences, vol. 289, no. 1971, pp. 1-8. Coni, EOC, Booth, DJ, Ferreira, CM & Nagelkerken, I 2022, 'Behavioural generalism could facilitate coexistence of tropical and temperate fishes under climate change', Journal of Animal Ecology, vol. 91, no. 1, pp. 86-100. Cook, M, Leigh, A & Watson, DM 2022, 'Temporary Translocation of Entire Mistletoe Plants to Understand the Mechanistic Basis of Animal Foraging Decisions', Journal of Visualized Experiments, vol. 2022, no. 183. Fruiting mistletoes present a model system for understanding decisions made by foraging animals when locating food. Where, when, and how animals find food is central to many ecological questions, relating to the basis of individual foraging decisions and the extent to which these decisions are innate or acquired. Ecologists have paid particular attention to frugivores, quantifying their preference for fruits with specific shapes, colors, or scents, which, over evolutionary time, confer selection for suites of traits in their favored plants whose seeds they disperse. This work outlines a novel experimental approach to manipulating food plant occurrence and measuring the response of wild, free-living animals, ideally suited to studying the evolutionary origin and ecological maintenance of seed dispersal. This 'cut and paste' protocol involves removing an entire fruiting mistletoe plant from its host and either returning it to its original location or moving it to a novel location, affixing it to a 'pseudo-host' of the same or different tree species. By counting visits to the mistletoe and noting the duration, species, and behaviors, a series of comparisons can discern the most important factors affecting foraging decisions and the consequences for both plant and animal. Here, the protocol is illustrated with a case study to determine between-guild differences in mistletoe frugivory. The experimental approach teases apart the mechanistic basis of search image formation and refinement, spatial learning, interspecific differences in foraging strategies, and how these changes modify seed dispersal effectiveness. Finally, potential modifications are considered with respect to addressing other questions on foraging ecology, plant-animal interactions, and coevolution. Corletto, A, Ellis, AV, Shepelin, NA, Fronzi, M, Winkler, DA, Shapter, JG & Sherrell, PC 2022, 'Energy Interplay in Materials: Unlocking Next‐Generation Synchronous Multisource Energy Conversion with Layered 2D Crystals', Advanced Materials, vol. 34, no. 36, pp. 1-18. Cowan, AE, Bailey, RL, Jun, S, Dodd, KW, Gahche, JJ, Eicher-Miller, HA, Guenther, PM, Dwyer, JT, Potischman, N, Bhadra, A, Carroll, RJ & Tooze, JA 2022, 'The Total Nutrient Index is a Useful Measure for Assessing Total Micronutrient Exposures Among US Adults', The Journal of Nutrition, vol. 152, no. 3, pp. 863-871. BACKGROUND: Most dietary indices reflect foods and beverages and do not include exposures from dietary supplements (DS) that provide substantial amounts of micronutrients. A nutrient-based approach that captures total intake inclusive of DS can strengthen exposure assessment. OBJECTIVE: To examine the construct and criterion validity of the Total Nutrient Index (TNI) among U.S. adults (≥19y; non-pregnant or lactating). METHODS: The TNI includes eight under-consumed micronutrients identified by the Dietary Guidelines for Americans: calcium; magnesium; potassium; choline; and vitamins A, C, D, and E. The TNI is expressed as a percentage of the Recommended Dietary Allowance or Adequate Intake to compute micronutrient component scores; the mean of the component scores yields the TNI score, ranging from 0-100. Data from exemplary menus and the 2003-2006 (≥19y; n = 8,861) and 2011-2014 NHANES (≥19y; n = 9,954) were employed. Exemplary menus were used to determine if the TNI yielded high scores from dietary sources (women 31-50y; men ≥70y). TNI scores were correlated with Healthy Eating Index (HEI)-2015 overall and component scores for dairy, fruits, and vegetables; TNI component scores for vitamins A, C, D, and E were correlated with respective biomarker data. TNI scores were compared between groups with known differences in nutrient intake based on the literature. RESULTS: The TNI yielded high scores on exemplary menus (84.8-93.3/100) and was moderately correlated (r = 0.48) with the HEI-2015. Mean TNI scores were significantly different for DS users (83.5) vs. non-users (67.1), non-smokers (76.8) vs. smokers (70.3), and those living with food security (76.6) vs. food insecurity (69.1). Correlations of TNI vitamin component scores with available biomarkers ranged from r = 0.12 (α-tocopherol) to r = 0.36 (serum 25(OH)D), and were significantly higher than correlations obtained from the diet alone. CONCLUSION: The evaluation of validity supports that the TNI i... Cramer, A, Galvão, I, Venturini de Sá, N, Gaio, P, Fernanda de Melo Oliveira, N, Rates Gonzaga Santos, M, Henrique Campolina-Silva, G, Vinicius Santos Valiate, B, Rezende Souza, F, Dantas Cassali, G, Martins Teixeira, M, Almeida Amaral, F & Simão Machado, F 2022, 'Role of Suppressor of cytokine signaling 2 during the development and resolution of an experimental arthritis', Cellular Immunology, vol. 372, pp. 104476-104476. Cranfield, CG, Le Brun, AP, Garcia, A, Cornell, BA & Holt, SA 2022, 'Langmuir-Schaefer Deposition to Create an Asymmetrical Lipopolysaccharide Sparsely Tethered Lipid Bilayer', Methods in Molecular Biology, vol. 2402, pp. 21-30. Because they are firmly anchored to a noble metal substrate, tethered bilayer lipid membranes (tBLMs) are considerably more robust than supported lipid bilayers such as black lipid membranes (BLMs) (Cranfield et al. Biophys J 106:182-189, 2014). The challenge to rapidly create asymmetrical tBLMs that include a lipopolysaccharide outer leaflet for bacterial model membrane research can be overcome by the use of a Langmuir-Schaefer deposition protocol. Here, we describe the procedures required to assemble and test asymmetric lipopolysaccharide (LPS) tethered lipid bilayers. Crispino, F, Weyermann, C, Delémont, O, Roux, C & Ribaux, O 2022, 'Towards another paradigm for forensic science?', WIREs Forensic Science, vol. 4, no. 3. Crowley, J, Withana, M & Deplazes, E 2022, 'The interaction of steroids with phospholipid bilayers and membranes', Biophysical Reviews, vol. 14, no. 1, pp. 163-179. Steroids are critical for various physiological processes and used to treat inflammatory conditions. Steroids act by two distinct pathways. The genomic pathway is initiated by the steroid binding to nuclear receptors while the non-genomic pathway involves plasma membrane receptors. It has been proposed that steroids might also act in a more indirect mechanism by altering biophysical properties of membranes. Yet, little is known about the effect of steroids on membranes, and steroid-membrane interactions are complex and challenging to characterise. The focus of this review is to outline what is currently known about the interactions of steroids with phospholipid bilayers and illustrate the complexity of these systems using cortisone and progesterone as the main examples. The combined findings from current work demonstrate that the hydrophobicity and planarity of the steroid core does not provide a consensus for steroid-membrane interactions. Even small differences in the substituents on the steroid core can result in significant changes in steroid-membrane interactions. Furthermore, steroid-induced changes in phospholipid bilayer properties are often dependent on steroid concentration and lipid composition. This complexity means that currently there is insufficient information to establish a reliable structure–activity relationship to describe the effect of steroids on membrane properties. Future work should address the challenge of connecting the findings from studying the effect of steroids on phospholipid bilayers to cell membranes. Insights from steroid-membrane interactions will benefit our understanding of normal physiology and assist drug development. Cui, E, Thompson, EC, Carroll, RJ & Ruppert, D 2022, 'A semiparametric risk score for physical activity', Statistics in Medicine, vol. 41, no. 7, pp. 1191-1204. Cummins, ML, Reid, CJ & Djordjevic, SP 2022, 'Erratum for Cummins et al., “F Plasmid Lineages in Escherichia coli ST95: Implications for Host Range, Antibiotic Resistance, and Zoonoses”', mSystems, vol. 7, no. 2, p. e0021022. Cummins, ML, Reid, CJ & Djordjevic, SP 2022, 'F Plasmid Lineages in Escherichia coli ST95: Implications for Host Range, Antibiotic Resistance, and Zoonoses', mSystems, vol. 7, no. 1. Cunliffe, AM, Anderson, K, Boschetti, F, Brazier, RE, Graham, HA, Myers‐Smith, IH, Astor, T, Boer, MM, Calvo, LG, Clark, PE, Cramer, MD, Encinas‐Lara, MS, Escarzaga, SM, Fernández‐Guisuraga, JM, Fisher, AG, Gdulová, K, Gillespie, BM, Griebel, A, Hanan, NP, Hanggito, MS, Haselberger, S, Havrilla, CA, Heilman, P, Ji, W, Karl, JW, Kirchhoff, M, Kraushaar, S, Lyons, MB, Marzolff, I, Mauritz, ME, McIntire, CD, Metzen, D, Méndez‐Barroso, LA, Power, SC, Prošek, J, Sanz‐Ablanedo, E, Sauer, KJ, Schulze‐Brüninghoff, D, Šímová, P, Sitch, S, Smit, JL, Steele, CM, Suárez‐Seoane, S, Vargas, SA, Villarreal, M, Visser, F, Wachendorf, M, Wirnsberger, H & Wojcikiewicz, R 2022, 'Global application of an unoccupied aerial vehicle photogrammetry protocol for predicting aboveground biomass in non‐forest ecosystems', Remote Sensing in Ecology and Conservation, vol. 8, no. 1, pp. 57-71. Daher, W, Leclercq, L-D, Johansen, MD, Hamela, C, Karam, J, Trivelli, X, Nigou, J, Guérardel, Y & Kremer, L 2022, 'Glycopeptidolipid glycosylation controls surface properties and pathogenicity in Mycobacterium abscessus', Cell Chemical Biology, vol. 29, no. 5, pp. 910-924.e7. Mycobacterium abscessus is an emerging and difficult-to-manage mycobacterial species that exhibits smooth (S) or rough (R) morphotypes. Disruption of glycopeptidolipid (GPL) production results in transition from S to R and severe lung disease. A structure-activity relationship study was undertaken to decipher the role of GPL glycosylation in morphotype transition and pathogenesis. Deletion of gtf3 uncovered the prominent role of the extra rhamnose in enhancing mannose receptor-mediated internalization of M. abscessus by macrophages. In contrast, the absence of the 6-deoxy-talose and the first rhamnose in mutants lacking gtf1 and gtf2, respectively, affected M abscessus phagocytosis but also resulted in the S-to-R transition. Strikingly, gtf1 and gtf2 mutants displayed a strong propensity to form cords and abscesses in zebrafish, leading to robust and lethal infection. Together, these results underscore the importance and differential contribution of GPL monosaccharides in promoting virulence and infection outcomes. Dang, HP, Chen, H, Dargaville, TR & Tuch, BE 2022, 'Cell delivery systems: Toward the next generation of cell therapies for type 1 diabetes', Journal of Cellular and Molecular Medicine, vol. 26, no. 18, pp. 4756-4767. Daniels, RK, Mallinson, JB, Heywood, ZE, Bones, PJ, Arnold, MD & Brown, SA 2022, 'Reservoir computing with 3D nanowire networks', Neural Networks, vol. 154, pp. 122-130. Darmarajan, T, Paudel, KR, Candasamy, M, Chellian, J, Madheswaran, T, Sakthivel, LP, Goh, BH, Gupta, PK, Jha, NK, Devkota, HP, Gupta, G, Gulati, M, Singh, SK, Hansbro, PM, Oliver, BGG, Dua, K & Chellappan, DK 2022, 'Autoantibodies and autoimmune disorders in SARS-CoV-2 infection: pathogenicity and immune regulation', Environmental Science and Pollution Research, vol. 29, no. 36, pp. 54072-54087. Das, SS, Dubey, AK, Verma, PRP, Singh, SK & Singh, SK 2022, 'Therapeutic Potential of Quercetin-Loaded Nanoemulsion against Experimental Visceral Leishmaniasis: In Vitro/Ex Vivo Studies and Mechanistic Insights', Molecular Pharmaceutics, vol. 19, no. 9, pp. 3367-3384. Das, SS, Singh, SK, Verma, PRP, Jha, NK, Gupta, PK & Dua, K 2022, 'Mitigating Inflammation Using Advanced Drug Delivery By Targeting TNF-α in Lung Diseases', Future Medicinal Chemistry, vol. 14, no. 2, pp. 57-60. Das, SS, Tambe, S, Prasad Verma, PR, Amin, P, Singh, N, Singh, SK & Gupta, PK 2022, 'Molecular Insights and Therapeutic Implications of Nanoengineered Dietary Polyphenols for Targeting Lung Cancer: Part II', Nanomedicine, vol. 17, no. 23, pp. 1799-1816. Das, SS, Tambe, S, Prasad Verma, PR, Amin, P, Singh, N, Singh, SK & Gupta, PK 2022, 'Molecular Insights and Therapeutic Implications of Nanoengineered Dietary Polyphenols for Targeting Lung Carcinoma: Part I', Nanomedicine, vol. 17, no. 23, pp. 1779-1798. Davies, JM, Smith, BA, Milic, A, Campbell, B, Van Haeften, S, Burton, P, Keaney, B, Lampugnani, ER, Vicendese, D, Medek, D, Huete, A, Erbas, B, Newbigin, E, Katelaris, CH, Haberle, SG & Beggs, PJ 2022, 'The AusPollen partnership project: Allergenic airborne grass pollen seasonality and magnitude across temperate and subtropical eastern Australia, 2016–2020', Environmental Research, vol. 214, no. Pt 1, pp. 113762-113762. BACKGROUND: Allergic rhinitis affects half a billion people globally, including a fifth of the Australian population. As the foremost outdoor allergen source, ambient grass pollen exposure is likely to be altered by climate change. The AusPollen Partnership aimed to standardize pollen monitoring and examine broad-scale biogeographical and meteorological factors influencing interannual variation in seasonality of grass pollen aerobiology in Australia. METHODS: Daily airborne grass and other pollen concentrations in four eastern Australian cities separated by over 1700 km, were simultaneously monitored using Hirst-style samplers following the Australian Interim Pollen and Spore Monitoring Standard and Protocols over four seasons from 2016 to 2020. The grass seasonal pollen integral was determined. Gridded rainfall, temperature, and satellite-derived grassland sources up to 100 km from the monitoring site were analysed. RESULTS: The complexity of grass pollen seasons was related to latitude with multiple major summer-autumn peaks in Brisbane, major spring and minor summer peaks in Sydney and Canberra, and single major spring peaks occurring in Melbourne. The subtropical site of Brisbane showed a higher proportion of grass out of total pollen than more temperate sites. The magnitude of the grass seasonal pollen integral was correlated with pasture greenness, rainfall and number of days over 30 °C, preceding and within the season, up to 100 km radii from monitoring sites. CONCLUSIONS: Interannual fluctuations in Australian grass pollen season magnitude are strongly influenced by regional biogeography and both pre- and in-season weather. This first continental scale, Southern Hemisphere standardized aerobiology dataset forms the basis to track shifts in pollen seasonality, biodiversity and impacts on allergic respiratory diseases. Dawson, BM, Wallman, JF & Barton, PS 2022, 'How does mass loss compare with total body score when assessing decomposition of human and pig cadavers?', Forensic Science, Medicine and Pathology, vol. 18, no. 3, pp. 343-351. Dawson, BM, Wallman, JF, Evans, MJ & Barton, PS 2022, 'Insect abundance patterns on vertebrate remains reveal carrion resource quality variation', Oecologia, vol. 198, no. 4, pp. 1043-1056. Dawson, BM, Wallman, JF, Evans, MJ, Butterworth, NJ & Barton, PS 2022, 'Priority effects and density promote coexistence between the facultative predator Chrysomya rufifacies and its competitor Calliphora stygia', Oecologia, vol. 199, no. 1, pp. 181-191. Day, DM, Butterworth, NJ, Tagat, A, Markowsky, G & Wallman, JF 2022, 'Development of larvae of the Australian blowfly,Calliphora augur(Diptera: Calliphoridae), at constant temperatures', Australian Journal of Forensic Sciences, vol. 54, no. 5, pp. 710-721. de Vries, M, Nwozor, KO, Muizer, K, Wisman, M, Timens, W, van den Berge, M, Faiz, A, Hackett, T-L, Heijink, IH & Brandsma, CA 2022, 'The relation between age and airway epithelial barrier function', Respiratory Research, vol. 23, no. 1. Degani, E, Maestrini, L, Toczydłowska, D & Wand, MP 2022, 'Sparse linear mixed model selection via streamlined variational Bayes', Electronic Journal of Statistics, vol. 16, no. 2, pp. 5182-5225. Linear mixed models are a versatile statistical tool to study data by accounting for fixed effects and random effects from multiple sources of variability. In many situations, a large number of candidate fixed effects is available and it is of interest to select a parsimonious subset of those being effectively relevant for predicting the response variable. Variational approximations facilitate fast approximate Bayesian inference for the parameters of a variety of statistical models, including linear mixed models. However, for models having a high number of fixed or random effects, simple application of standard variational inference principles does not lead to fast approximate inference algorithms, due to the size of model design matrices and inefficient treatment of sparse matrix problems arising from the required approximating density parameters updates. We illustrate how recently developed streamlined variational inference procedures can be generalized to make fast and accurate inference for the parameters of linear mixed models with nested random effects and global-local priors for Bayesian fixed effects selection. Our variational inference algorithms achieve convergence to the same optima of their standard imple-mentations, although with significantly lower computational effort, mem-ory usage and time, especially for large numbers of random effects. Using simulated and real data examples, we assess the quality of automated procedures for fixed effects selection that are free from hyperparameters tuning and only rely upon variational posterior approximations. Moreover, we show high accuracy of variational approximations against model fitting via Markov Chain Monte Carlo sampling. Deignan, LK & McDougald, D 2022, 'Differential Response of the Microbiome of Pocillopora acuta to Reciprocal Transplantation Within Singapore', Microbial Ecology, vol. 83, no. 3, pp. 608-618. Dennis, J, Tyrer, JP, Walker, LC, Michailidou, K, Dorling, L, Bolla, MK, Wang, Q, Ahearn, TU, Andrulis, IL, Anton-Culver, H, Antonenkova, NN, Arndt, V, Aronson, KJ, Freeman, LEB, Beckmann, MW, Behrens, S, Benitez, J, Bermisheva, M, Bogdanova, NV, Bojesen, SE, Brenner, H, Castelao, JE, Chang-Claude, J, Chenevix-Trench, G, Clarke, CL, Kristensen, VN, Sahlberg, KK, Børresen-Dale, A-L, Gram, IT, Engebråten, O, Naume, B, Geisler, J, Alnæs, GIG, Collée, JM, Lacey, J, Martinez, E, Couch, FJ, Cox, A, Cross, SS, Czene, K, Devilee, P, Dörk, T, Dossus, L, Eliassen, AH, Eriksson, M, Evans, DG, Fasching, PA, Figueroa, J, Fletcher, O, Flyger, H, Fritschi, L, Gabrielson, M, Gago-Dominguez, M, García-Closas, M, Giles, GG, González-Neira, A, Guénel, P, Hahnen, E, Haiman, CA, Hall, P, Hollestelle, A, Hoppe, R, Hopper, JL, Howell, A, Clarke, C, Carpenter, J, Marsh, D, Scott, R, Baxter, R, Yip, D, Davis, A, Pathmanathan, N, Simpson, P, Graham, D, Sachchithananthan, M, Campbell, I, de Fazio, A, Fox, S, Kirk, J, Lindeman, G, Milne, R, Southey, M, Spurdle, A, Thorne, H, Jager, A, Jakubowska, A, John, EM, Johnson, N, Jones, ME, Jung, A, Kaaks, R, Keeman, R, Khusnutdinova, E, Kitahara, CM, Ko, Y-D, Kosma, V-M, Koutros, S, Kraft, P, Kristensen, VN, Kubelka-Sabit, K, Kurian, AW, Lacey, JV, Lambrechts, D, Larson, NL, Linet, M, Ogrodniczak, A, Mannermaa, A, Manoukian, S, Margolin, S, Mavroudis, D, Milne, RL, Muranen, TA, Murphy, RA, Nevanlinna, H, Olson, JE, Olsson, H, Park-Simon, T-W, Perou, CM, Peterlongo, P, Plaseska-Karanfilska, D, Pylkäs, K, Rennert, G, Saloustros, E, Sandler, DP, Sawyer, EJ, Schmidt, MK, Schmutzler, RK, Shibli, R, Smeets, A, Soucy, P, Southey, MC, Swerdlow, AJ, Tamimi, RM, Taylor, JA, Teras, LR, Terry, MB, Tomlinson, I, Troester, MA, Truong, T, Vachon, CM, Wendt, C, Winqvist, R, Wolk, A, Yang, XR, Zheng, W, Ziogas, A, Simard, J, Dunning, AM, Pharoah, PDP & Easton, DF 2022, 'Rare germline copy number variants (CNVs) and breast cancer risk', Communications Biology, vol. 5, no. 1, p. 65. Dhanjal, DS, Sharma, P, Mehta, M, Tambuwala, MM, Prasher, P, Paudel, KR, Liu, G, Shukla, SD, Hansbro, PM, Chellappan, DK, Dua, K & Satija, S 2022, 'Concepts of Advanced Therapeutic Delivery Systems for the Management of Remodeling and Inflammation in Airway Diseases', Future Medicinal Chemistry, vol. 14, no. 4, pp. 271-288. Di, X, Wang, D, Su, QP, Liu, Y, Liao, J, Maddahfar, M, Zhou, J & Jin, D 2022, 'Spatiotemporally mapping temperature dynamics of lysosomes and mitochondria using cascade organelle-targeting upconversion nanoparticles', Proceedings of the National Academy of Sciences, vol. 119, no. 45, p. e2207402119. DiBattista, JD, Fowler, AM, Riley, IJ, Reader, S, Hay, A, Parkinson, K & Hobbs, J-PA 2022, 'The use of environmental DNA to monitor impacted coastal estuaries', Marine Pollution Bulletin, vol. 181, pp. 113860-113860. Environmental DNA (eDNA) metabarcoding is increasingly being used to assess community composition in coastal ecosystems. In this study, we chose to examine temporal and spatial changes in the aquatic community of Manly Lagoon - one of the most heavily developed and polluted estuaries in eastern Australia. Based on metabarcoding of the 16S mitochondrial gene (for fish) and the 18S nuclear gene (for macroinvertebrates), we identified seasonal differences in fish and macroinvertebrate community composition as well as species richness, which correlated, in some cases, with the environmental parameters of sea surface temperature and freshwater input. Moreover, given the greater taxonomic resolution of fish versus macroinvertebrate assignments, we identified several known migratory fish species of management importance that contributed significantly to the overall patterns observed. Overall, our data support the use of eDNA metabarcoding to track fish assemblages shifting in response to environmental drivers in polluted estuaries with increased sampling and consultation with historical data. Dietrich, H, Elder, M, Piggott, A, Qiao, Y & Weiß, A 2022, 'The Isomorphism Problem for Plain Groups Is in ΣP Testing isomorphism of infinite groups is a classical topic, but from the complexity theory viewpoint, few results are known. Sénizergues and the fifth author (ICALP2018) proved that the isomorphism problem for virtually free groups is decidable in PSPACE when the input is given in terms of so-called virtually free presentations. Here we consider the isomorphism problem for the class of plain groups, that is, groups that are isomorphic to a free product of finitely many finite groups and finitely many copies of the infinite cyclic group. Every plain group is naturally and efficiently presented via an inverse-closed finite convergent length-reducing rewriting system. We prove that the isomorphism problem for plain groups given in this form lies in the polynomial time hierarchy, more precisely, in ΣP3. This result is achieved by combining new geometric and algebraic characterisations of groups presented by inverse-closed finite convergent length-reducing rewriting systems developed in recent work of the second and third authors (2021) with classical finite group isomorphism results of Babai and Szemerédi (1984). Dikshit, A, Pradhan, B, Huete, A & Park, H-J 2022, 'Spatial based drought assessment: Where are we heading? A review on the current status and future', Science of The Total Environment, vol. 844, pp. 157239-157239. Droughts are the most spatially complex natural hazards that exert global impacts and are further aggravated by climate change. The investigation of drought events is challenging as it involves numerous factors ranging from detection and assessment to modelling, management and mitigation. The analysis of these factors and their quantitative assessments have significantly evolved in recent times. In this paper, we review recent methods used to examine and model droughts from a spatial viewpoint. Our analysis was conducted at three spatial scales (point-wise, regional and global) and we evaluated how recent spatial methods have advanced our understanding of drought through case study examples. Further, we also examine and provide a broad overview of relevant case studies related to future drought occurrences under climate change. This study is a comprehensive synthesis of the various quantitative techniques used to assess the spatial characteristics of droughts at different spatial scales, and not an exhaustive review of all drought aspects. However, this serves as a basis for understanding the key milestones and advances accomplished through new spatial concepts relative to the traditional approaches to study drought. This work also aims to address the gaps in knowledge that are in need of further attention and provides recommendations to improve our understanding of droughts. Ding, L, Razavi Bazaz, S, Asadniaye Fardjahromi, M, McKinnirey, F, Saputro, B, Banerjee, B, Vesey, G & Ebrahimi Warkiani, M 2022, 'A modular 3D printed microfluidic system: a potential solution for continuous cell harvesting in large-scale bioprocessing', Bioresources and Bioprocessing, vol. 9, no. 1. Ding, L, Razavi Bazaz, S, Hall, T, Vesey, G & Ebrahimi Warkiani, M 2022, 'Giardia purification from fecal samples using rigid spiral inertial microfluidics', Biomicrofluidics, vol. 16, no. 1, pp. 014105-014105. Ding, L, Razavi Bazaz, S, Shrestha, J, A. Amiri, H, Mas-hafi, S, Banerjee, B, Vesey, G, Miansari, M & Ebrahimi Warkiani, M 2022, 'Rapid and Continuous Cryopreservation of Stem Cells with a 3D Micromixer', Micromachines, vol. 13, no. 9, pp. 1516-1516. Ding, L, Shan, X, Wang, D, Liu, B, Du, Z, Di, X, Chen, C, Maddahfar, M, Zhang, L, Shi, Y, Reece, P, Halkon, B, Aharonovich, I, Xu, X & Wang, F 2022, 'Lanthanide Ion Resonance‐Driven Rayleigh Scattering of Nanoparticles for Dual‐Modality Interferometric Scattering Microscopy', Advanced Science, vol. 9, no. 32, pp. e2203354-2203354. Ding, L, Shan, X, Wang, D, Liu, B, Du, Z, Di, X, Chen, C, Maddahfar, M, Zhang, L, Shi, Y, Reece, P, Halkon, B, Aharonovich, I, Xu, X & Wang, F 2022, 'Lanthanide Ion Resonance‐Driven Rayleigh Scattering of Nanoparticles for Dual‐Modality Interferometric Scattering Microscopy (Adv. Sci. 32/2022)', Advanced Science, vol. 9, no. 32. Ditz, B, Boekhoudt, J, Couto, N, Brandsma, CA, Hiemstra, PS, Tew, GW, Neighbors, M, Grimbaldeston, MA, Timens, W, Kerstjens, HAM, Rossen, JWA, Guryev, V, van den Berge, M & Faiz, A 2022, 'The Microbiome in Bronchial Biopsies from Smokers and Ex-Smokers with Stable COPD - A Metatranscriptomic Approach', COPD: Journal of Chronic Obstructive Pulmonary Disease, vol. 19, no. 1, pp. 81-87. Don Wai Luu, L, Kaakoush, NO & Castaño-Rodríguez, N 2022, 'The role of ATG16L2 in autophagy and disease', Autophagy, vol. 18, no. 11, pp. 2537-2546. Donovan, C, Kim, RY, Galvao, I, Jarnicki, AG, Brown, AC, Jones‐Freeman, B, Gomez, HM, Wadhwa, R, Hortle, E, Jayaraman, R, Khan, H, Pickles, S, Sahu, P, Chimankar, V, Tu, X, Ali, MK, Mayall, JR, Nguyen, DH, Budden, KF, Kumar, V, Schroder, K, Robertson, AAB, Cooper, MA, Wark, PAB, Oliver, BG, Horvat, JC & Hansbro, PM 2022, 'Aim2 suppresses cigarette smoke‐induced neutrophil recruitment, neutrophil caspase‐1 activation and anti‐Ly6G‐mediated neutrophil depletion', Immunology & Cell Biology, vol. 100, no. 4, pp. 235-249. dos Remedios, C, Cranfield, C, Whelan, D, Cox, C, Shearwin, K, Ho, J, Allen, T, Shibuya, R, Hibino, E, Hayashi, K & Li, A 2022, 'A special issue of the Australian society for Biophysics', Biophysical Reviews, vol. 14, no. 1, pp. 1-2. Douglas, ANJ, Morgan, AL, Irga, PJ & Torpy, FR 2022, 'The need for multifaceted approaches when dealing with the differing impacts of natural disasters and anthropocentric events on air quality', Atmospheric Pollution Research, vol. 13, no. 11, pp. 101570-101570. Dower, A, Mulcahy, M, Maharaj, M, Chen, H, Lim, CED, Li, Y & Sheridan, M 2022, 'Surgical decompression for malignant cerebral oedema after ischaemic stroke', Cochrane Database of Systematic Reviews, vol. 2022, no. 11, p. CD014989. BACKGROUND: Large territory middle cerebral artery (MCA) ischaemic strokes account for around 10% of all ischaemic strokes and have a particularly devastating prognosis when associated with malignant oedema. Progressive cerebral oedema starts developing in the first 24 to 48 hours of stroke ictus with an associated rise in intracranial pressure. The rise in intracranial pressure may eventually overwhelm compensatory mechanisms leading to a cascading secondary damage to surrounding unaffected parenchyma. This downward spiral can rapidly progress to death or severe neurological disability. Early decompressive craniectomy to relieve intracranial pressure and associated tissue shift can help ameliorate this secondary damage and improve outcomes. Evidence has been accumulating of the benefit of early surgical decompression in stroke patients. Earlier studies have excluded people above the age of 60 due to associated poor outcomes; however, newer trials have included this patient subgroup. This review follows a Cochrane Review published in 2012. OBJECTIVES: To assess the effectiveness of surgical decompression in people with malignant oedema after ischaemic stroke with regard to reduction in mortality and improved functional outcome. We also aimed to examine the adverse effects of surgical decompression in this patient cohort. SEARCH METHODS: We searched the Cochrane Stroke Group Trials Register, the Cochrane Central Register of Controlled Trials (CENTRAL; 2022, Issue 7 of 12), MEDLINE Ovid, Embase Ovid, Web of Science Core Collection, Scopus databases, ClinicalTrials.gov, and the WHO ICTRP to July 2022. We also reviewed the reference lists of relevant articles. SELECTION CRITERIA: We included randomised controlled trials (RCTs) comparing decompressive craniectomy with medical management to best medical management alone for people with malignant cerebral oedema after MCA ischaemic stroke. DATA COLLECTION AND ANALYSIS: Two review authors independently screened... Dubern, J-F, Romero, M, Mai-Prochnow, A, Messina, M, Trampari, E, Gijzel, HN-V, Chan, K-G, Carabelli, AM, Barraud, N, Lazenby, J, Chen, Y, Robertson, S, Malone, JG, Williams, P, Heeb, S & Cámara, M 2022, 'ToxR is a c-di-GMP binding protein that modulates surface-associated behaviour in Pseudomonas aeruginosa', npj Biofilms and Microbiomes, vol. 8, no. 1, p. 64. Dukic, E, Gollan, PJ, Grebe, S, Paakkarinen, V, Herdean, A, Aro, E-M & Spetea, C 2022, 'The Arabidopsis thylakoid chloride channel ClCe regulates ATP availability for light-harvesting complex II protein phosphorylation', Frontiers in Plant Science, vol. 13, no. Women in Plant Physiology: 2022. Duncan, RJ & Petrou, K 2022, 'Biomolecular Composition of Sea Ice Microalgae and Its Influence on Marine Biogeochemical Cycling and Carbon Transfer through Polar Marine Food Webs', Geosciences, vol. 12, no. 1, pp. 38-38. Duncan, RJ, Nielsen, DA, Sheehan, CE, Deppeler, S, Hancock, AM, Schulz, KG, Davidson, AT & Petrou, K 2022, 'Ocean acidification alters the nutritional value of Antarctic diatoms', New Phytologist, vol. 233, no. 4, pp. 1813-1827. Dylgjeri, E, Kothari, V, Shafi, AA, Semenova, G, Gallagher, PT, Guan, YF, Pang, A, Goodwin, JF, Irani, S, McCann, JJ, Mandigo, AC, Chand, S, McNair, CM, Vasilevskaya, I, Schiewer, MJ, Lallas, CD, McCue, PA, Gomella, LG, Seifert, EL, Carroll, JS, Butler, LM, Holst, J, Kelly, WK & Knudsen, KE 2022, 'A Novel Role for DNA-PK in Metabolism by Regulating Glycolysis in Castration-Resistant Prostate Cancer', Clinical Cancer Research, vol. 28, no. 7, pp. 1446-1459. Ebrahimnezhaddarzi, S, Bird, CH, Allison, CC, Tuipulotu, DE, Kostoulias, X, Macri, C, Stutz, MD, Abraham, G, Kaiserman, D, Pang, SS, Man, SM, Mintern, JD, Naderer, T, Peleg, AY, Pellegrini, M, Whisstock, JC & Bird, PI 2022, 'Mpeg1 is not essential for antibacterial or antiviral immunity, but is implicated in antigen presentation', Immunology & Cell Biology, vol. 100, no. 7, pp. 529-546. Edla, M, Mikio, D, Izadgoshasb, I, Mahmud, MAP & Kouzani, AZ 2022, 'Self-powered boost-converter for power optimisation and piezo garden lights', Smart Materials and Structures, vol. 31, no. 4, pp. 045021-045021. Eggleton, BJ, Steel, MJ & Poulton, CG 2022, 'Preface', pp. xiii-xviii. Eilers, K, Kuok Hoong Yam, J, Morton, R, Mei Hui Yong, A, Brizuela, J, Hadjicharalambous, C, Liu, X, Givskov, M, Rice, SA & Filloux, A 2022, 'Phenotypic and integrated analysis of a comprehensive Pseudomonas aeruginosa PAO1 library of mutants lacking cyclic-di-GMP-related genes', Frontiers in Microbiology, vol. 13, pp. 1-21. Elankumaran, P, Browning, GF, Marenda, MS, Reid, CJ & Djordjevic, SP 2022, 'Close genetic linkage between human and companion animal extraintestinal pathogenic Escherichia coli ST127', Current Research in Microbial Sciences, vol. 3, pp. 100106-100106. Elankumaran, P, Cummins, ML, Browning, GF, Marenda, MS, Reid, CJ & Djordjevic, SP 2022, 'Genomic and Temporal Trends in Canine ExPEC Reflect Those of Human ExPEC', Microbiology Spectrum, vol. 10, no. 3. Elbadawi, C, Kianinia, M, Bendavid, A & Lobo, CJ 2022, 'Charged Particle Induced Etching and Functionalization of Two-Dimensional Materials', ECS Journal of Solid State Science and Technology, vol. 11, no. 3, pp. 035011-035011. Elbourne, LDH, Sutcliffe, B, Humphreys, W, Focardi, A, Saccò, M, Campbell, MA, Paulsen, IT & Tetu, SG 2022, 'Unravelling Stratified Microbial Assemblages in Australia’s Only Deep Anchialine System, The Bundera Sinkhole', Frontiers in Marine Science, vol. 9. Elbourne, M, Cawley, A, Stanley, S, Bowen, C & Fu, S 2022, 'Intelligence benefit of the 3‐methoxytyramine to tyramine ratio in equine urine', Drug Testing and Analysis, vol. 14, no. 5, pp. 936-942. Eldehna, WM, Maklad, RM, Almahli, H, Al-Warhi, T, Elkaeed, EB, Abourehab, MAS, Abdel-Aziz, HA & El Kerdawy, AM 2022, 'Identification of 3-(piperazinylmethyl)benzofuran derivatives as novel type II CDK2 inhibitors: design, synthesis, biological evaluation, and in silico insights', Journal of Enzyme Inhibition and Medicinal Chemistry, vol. 37, no. 1, pp. 1227-1240. Elder, M & Piggott, A 2022, 'Rewriting systems, plain groups, and geodetic graphs', Theoretical Computer Science, vol. 903, pp. 134-144. Emmerson, KM, Addison-Smith, E, Ebert, E, Milic, A, Vicendese, D, Lampugnani, ER, Erbas, B, Medek, DE, Huete, A, Beggs, P, Katelaris, CH, Haberle, SG, Newbigin, E & Davies, JM 2022, 'Evaluation of the performance of short-term curated daily airborne grass pollen forecasts in diverse biogeographical regions during the AusPollen Partnership project 2016–2020', Atmospheric Environment: X, vol. 15, pp. 100183-100183. When providing pollen forecasts to the community, there is a need to verify the accuracy of curated forecasts, but evaluation is not routinely reported. This study of the AusPollen Partnership compared multi-category grass pollen forecasts for up to six days ahead with daily airborne grass pollen concentrations measured in Brisbane, Canberra, Melbourne, and Sydney, Australia during four pollen seasons from 2016 to 2020. The accuracy of categorical grass pollen forecasts predicting grass pollen concentrations in the high and greater, or moderate and greater categories, were assessed as often applied in meteorology using Gerrity scores, equitable threat scores, false alarm ratios, success ratios, and probability of detection of correct category. The skill of grass pollen forecasts curated by aerobiologists were compared with two retrospectively calculated naïve reference forecast methods; climatology and persistence. For Brisbane and Melbourne, high or greater grass pollen levels occurred on average 32% and 22% of days, whereas for Canberra and Sydney, there were few high days, but moderate or greater pollen levels occurred on average 26% and 19% of days, respectively. Average annual Gerrity scores for curated forecasts of high or greater improved with experience from 0.20 to 0.66 in Brisbane, and from 0.39 to 0.55 in Melbourne between 2016 and 2019. Average Gerrity Scores for moderate or greater categories in Sydney were 0.45 and 0.43 in 2016 and 2018 respectively, and in Canberra were 0.34 and 0.41, in the same years. The skill of curated forecasts was usually better than persistence forecasts, but the accuracy of the curated forecasts decreased with longer lead times. Although persistence grass pollen forecasts consistently performed better than climatologies, persistence depends on previous day pollen concentrations being available. Short-term curated daily grass pollen forecasts of the AusPollen Partnership offer useful information for people with al... Etchart, MG, Anderson, LL, Ametovski, A, Jones, PM, George, AM, Banister, SD & Arnold, JC 2022, 'In vitro evaluation of the interaction of the cannabis constituents cannabichromene and cannabichromenic acid with ABCG2 and ABCB1 transporters', European Journal of Pharmacology, vol. 922, pp. 174836-174836. Etminaniesfahani, A, Gu, H & Salehipour, A 2022, 'ABFIA: A hybrid algorithm based on artificial bee colony and Fibonacci indicator algorithm', Journal of Computational Science, vol. 61, pp. 101651-101651. Facey, JA, King, JJ, Apte, SC & Mitrovic, SM 2022, 'Assessing the importance of cobalt as a micronutrient for freshwater cyanobacteria', Journal of Phycology, vol. 58, no. 1, pp. 71-79. Facey, JA, Michie, LE, King, JJ, Hitchcock, JN, Apte, SC & Mitrovic, SM 2022, 'Severe cyanobacterial blooms in an Australian lake; causes and factors controlling succession patterns', Harmful Algae, vol. 117, pp. 102284-102284. Cyanobacterial blooms have major impacts on the ecological integrity and anthropogenic value of freshwater systems. Chrysosporum ovalisporum, a potentially toxic cyanobacteria has been rare in Australian waters until recently when is has bloomed in a number of lake and river systems. The aim of this study was to determine drivers of its growth and growing dominance. We performed regular monitoring of Mannus Lake, a small freshwater reservoir in South-Eastern Australia that has recently undergone extremely dense bloom events. Blooms of the diazotrophic Chrysosporum ovalisporum occurred in both summers of the 19 month study during periods of persistent thermal stratification. Following the C. ovalisporum blooms, non-diazotrophic taxa (Microcystis aeruginosa and Woronichinia sp.) dominated the phytoplankton community under less stratified conditions. Thermal stratification and nitrogen availability appeared to be the primary drivers of changes in cyanobacterial community structure. We propose that the observed transition from C. ovalisporum to M. aeruginosa and/or Woronichinia sp. may be a result of nitrogen limitation in early summer, which combined with persistent thermal stratification led to an ecological advantage for the nitrogen-fixing C. ovalisporum. Mixing events caused the senescence of the C. ovalisporum bloom, likely supplementing the nutrient budget of the lake with atmospherically derived N and alleviating N limitation to non-diazotrophic taxa. Non-diazotrophic cyanobacterial growth then increased, albeit at much lower biovolumes compared to the initial bloom. Overall, the results demonstrate the role of thermal stratification and nutrient cycling in structuring the cyanobacterial community and provide insights into the environmental factors driving the proliferation of the relatively new, potentially toxic cyanobacterium C. ovalisporum in Australian waters. Facey, JA, Violi, JP, King, JJ, Sarowar, C, Apte, SC & Mitrovic, SM 2022, 'The Influence of Micronutrient Trace Metals on Microcystis aeruginosa Growth and Toxin Production', Toxins, vol. 14, no. 11, pp. 812-812. Fairley, LH, Grimm, A & Eckert, A 2022, 'Mitochondria Transfer in Brain Injury and Disease', Cells, vol. 11, no. 22, pp. 3603-3603. Faiz, A & van den Berge, M 2022, 'Quality over quantity: the importance of collecting relevant samples to understand complex diseases', European Respiratory Journal, vol. 59, no. 5, pp. 2200418-2200418. Fam, J, Clemens, KJ, Westbrook, RF, Morris, MJ & Kendig, MD 2022, 'Chronic exposure to cafeteria-style diet in rats alters sweet taste preference and reduces motivation for, but not ‘liking’ of sucrose', Appetite, vol. 168, pp. 105742-105742. Obesity is associated with changes to taste perception and brain reward circuitry. It is important to understand how these effects alter the preference for palatable foods and drinks, given that these are widely consumed, and leading risk factors for obesity. This study examined the effects of diet-induced obesity on sweet taste preference by analysing the microstructure of licking for sugar solutions and assessing pERK expression in the nucleus accumbens shell and insula. Adult male Sprague-Dawley rats were fed standard chow (Control; n = 16) or a varied, palatable cafeteria diet (Caf; n = 16) for 12 weeks. Two-choice preference tests between 2%, 8% and 32% sucrose solutions were conducted at baseline and in weeks 11-12 of the diet. Rats in the Caf group trebled energy intake and doubled weight gain relative to controls. In tests held under water restriction after 11 weeks of diet, the Control group reliably preferred higher sucrose concentrations (i.e., 32% > 8% > 2%). Relative to controls, the Caf group showed a stronger preference for 32% vs. 2% sucrose, lower preference for 32% vs. 8% sucrose, and were indifferent to 8% vs. 2% sucrose. Testing without water restriction increased preference for higher sucrose concentrations in both groups. Chronic Caf diet increased the latency to lick, decreased total licks and reduced alternations between spouts, but did not alter lick cluster size, a measure of hedonic appraisal, on any test. Following a final exposure to a novel sucrose concentration, neuronal activity (pERK) in the insula and nucleus accumbens shell was significantly reduced in the Caf group. Results indicate that differences in 'liking' do not underlie obesity-induced changes to sweet taste preference. Fan, W, Wang, B, Gao, R, Dimitrakopoulos, G, Wang, J, Xiao, X, Ma, L, Wu, K, Yildiz, B & Li, J 2022, 'Anodic Shock-Triggered Exsolution of Metal Nanoparticles from Perovskite Oxide', Journal of the American Chemical Society, vol. 144, no. 17, pp. 7657-7666. Fang, G, Lu, H, Al-Nakashli, R, Chapman, R, Zhang, Y, Ju, LA, Lin, G, Stenzel, MH & Jin, D 2022, 'Enabling peristalsis of human colon tumor organoids on microfluidic chips', Biofabrication, vol. 14, no. 1, pp. 015006-015006. Fang, XM, Liu, Y, Wang, J, Zhang, X, Wang, L, Zhang, L, Zhang, HP, Liu, L, Huang, D, Liu, D, Deng, K, Luo, FM, Wan, HJ, Li, WM, Wang, G & Oliver, BG 2022, 'Endogenous Adenosine 5′-Monophosphate, But Not Acetylcholine or Histamine, is Associated with Asthma Control, Quality of Life, and Exacerbations', Lung, vol. 200, no. 5, pp. 579-589. OBJECTIVE: Endogenous adenosine 5'-monophosphate (AMP), acetylcholine (ACh), and histamine (HA) are known to be important in bronchial contraction, but their clinical relevance to asthma is poorly understood. We aimed to quantify endogenous AMP, ACh, and HA in induced sputum samples and explore their relationships with asthma control and exacerbations. METHODS: 20 healthy subjects and 112 asthmatics underwent clinical assessment, sputum induction, and blood sampling. The level of asthma control was determined by the asthma control test (ACT) questionnaire. Asthma exacerbation was evaluated according to the criteria of the American Thoracic Society/European Respiratory Society. Levels of AMP, ACh, and HA in sputum were measured by liquid chromatography coupled to tandem mass spectrometry. IL-β, IL-4, IL-5, IL-6, IL-8, IL-13, IL-17A, TNF-α, IFN-γ, and macrophage-derived chemokine (MDC) were also measured. RESULTS: Compared to healthy controls, asthmatics had higher levels of HA, lower levels of ACh, and similar levels of AMP in induced sputum samples. Compared to controlled asthma (n = 54), uncontrolled asthma (n = 58) showed higher AMP levels (P = 0.002), but similar HA and ACh levels. AMP was negatively correlated with ACT scores (r = - 0.348) and asthma quality of life questionnaire scores (r = - 0.188) and positively correlated with blood monocytes percentage (r = 0.195), sputum MDC (r = 0.214), and IL-6 levels (r = 0.196). Furthermore, AMP was associated with an increased risk of exacerbations in the preceding year. CONCLUSION: Endogenous AMP, but not ACh or HA, was associated with asthma control, quality of life, and exacerbations in the previous year, which indicates that AMP could be a clinically useful biomarker of asthma. Farabi, L, Rehn, S & Boakes, RA 2022, 'Caffeine-based flavor preference conditioning in the rat', Learning & Behavior, vol. 50, no. 2, pp. 222-232. Farahmandjou, M, Zhao, S, Lai, W-H, Sun, B, Notten, PHL & Wang, G 2022, 'Oxygen redox chemistry in lithium-rich cathode materials for Li-ion batteries: Understanding from atomic structure to nano-engineering', Nano Materials Science, vol. 4, no. 4, pp. 322-338. Fares, M, Canfield, P, Alsherbiny, MA, Lewis, W, Willis, AC, Guang Li, C, Neyts, J, Jochmans, D, Gale, PA & Keller, PA 2022, 'Synthesis, X-ray crystallographic analysis, DFT studies and biological evaluation of triazolopyrimidines and 2-anilinopyrimidines', Journal of Molecular Structure, vol. 1252, pp. 132092-132092. Favaloro, J, Bryant, C, Abadir, E, Yang, S, Gardiner, S, Nassif, N, Sedger, L, Joshua, D & Ho, PJ 2022, 'OAB-023: Single-cell analysis reveals disease induced perturbations of CD8+T-cell subsets in the bone marrow and peripheral blood of newly diagnosed multiple myeloma patients', Clinical Lymphoma Myeloma and Leukemia, vol. 22, pp. S14-S14. Feng, OY, Chen, Y, Han, Q, Carroll, RJ & Samworth, RJ 2022, 'Nonparametric, Tuning-Free Estimation of S-Shaped Functions', Journal of the Royal Statistical Society Series B: Statistical Methodology, vol. 84, no. 4, pp. 1324-1352. Feng, S, Ngo, HH, Guo, W, Chang, SW, Nguyen, DD, Liu, Y, Zhang, S, Phong Vo, HN, Bui, XT & Ngoc Hoang, B 2022, 'Volatile fatty acids production from waste streams by anaerobic digestion: A critical review of the roles and application of enzymes', Bioresource Technology, vol. 359, pp. 127420-127420. Volatile fatty acids (VFAs) produced from organic-rich wastewater by anaerobic digestion attract attention due to the increasing volatile fatty acids market, sustainability and environmentally friendly characteristics. This review aims to give an overview of the roles and applications of enzymes, a biocatalyst which plays a significant role in anaerobic digestion, to enhance volatile fatty acids production. This paper systematically overviewed: (i) the enzymatic pathways of VFAs formation, competition, and consumption; (ii) the applications of enzymes in VFAs production; and (iii) feasible measures to boost the enzymatic processes. Furthermore, this review presents a critical evaluation on the major obstacles and feasible future research directions for the better applications of enzymatic processes to promote VFAs production from wastewater. Fernandes, KE, Frost, EA, Remnant, EJ, Schell, KR, Cokcetin, NN & Carter, DA 2022, 'The role of honey in the ecology of the hive: Nutrition, detoxification, longevity, and protection against hive pathogens', Frontiers in Nutrition, vol. 9, p. 954170. Fernandez, TT, Johnston, B, Gross, S, Cozic, S, Poulain, M, Mahmodi, H, Kabakova, I, Withford, M & Fuerbach, A 2022, 'Ultrafast laser inscribed waveguides in tailored fluoride glasses: an enabling technology for mid-infrared integrated photonics devices', Scientific Reports, vol. 12, no. 1, p. 14674. Fernandez, TT, Johnston, B, Mahmodi, H, Privat, K, Kabakova, I, Gross, S, Withford, M & Fuerbach, A 2022, 'Thermally stable high numerical aperture integrated waveguides and couplers for the 3 μm wavelength range', APL Photonics, vol. 7, no. 12, pp. 126106-126106. Ferrell, KC, Johansen, MD, Triccas, JA & Counoupas, C 2022, 'Virulence Mechanisms of Mycobacterium abscessus: Current Knowledge and Implications for Vaccine Design', Frontiers in Microbiology, vol. 13, pp. 1-21. Fleck, R, Gill, R, Pettit, TJ, Torpy, FR & Irga, PJ 2022, 'Bio-solar green roofs increase solar energy output: The sunny side of integrating sustainable technologies', Building and Environment, vol. 226, pp. 109703-109703. In urban spaces, localised energy generation through rooftop solar has become increasingly popular, and green roofs are often used for a range of services such as thermal insulation. In recent years, the adoption of Bio-solar green roofs (BSGR) for both thermal insulation and increased solar energy outputs has increased. Here we present two buildings of the same dimensions and location, similar age and construction material, where one hosts a BSGR, and the other a conventional solar roof (CSR) in Sydney, Australia. Each solar array hosted a range of environmental sensors, including ambient temperature and global horizontal irradiance (GHI). The modelled BSGR average hourly energy output was 4.5% higher than the CSR (seasonal trends observed Spring; 4.14%, Summer; 4.16%, and Autumn; 5.21%) with BSGR producing 14.26 MWh more than the CSR, valued at $4526.22 AUD, and equal to 11.55 t e-CO2 greenhouse gas mitigation. Further potential for up to 1.55 t of CO2 could be mitigated by the plant material on the roof, provided the trimming of plant material during maintenance is conducted responsibly. In this instance, the implementation of a BSGR increased the system's solar output by 23.88 kWh per m2 of panel coverage, as well as reducing the e-CO2 emissions by 0.019 t per m2 over the CSR. When compared to the results of previously reported pilot studies and some simulations, it is evident that the implementation of a BSGR is favourable for maximising energy production and the mitigation of GHGs. Fleck, R, Gill, RL, Saadeh, S, Pettit, T, Wooster, E, Torpy, F & Irga, P 2022, 'Urban green roofs to manage rooftop microclimates: A case study from Sydney, Australia', Building and Environment, vol. 209, pp. 108673-108673. Urbanisation has led to a growing need for sustainable development leading to climate resilient cities. As the urban heat burden increases in severity, technologies to improve the thermal comfort of cities are increasingly required. Green roofs are one such technology that can provide increased building thermal performance. In this study, we investigate two identical buildings, except, one was equipped with a green roof, and the other without. We present the longest-term assessment conducted on an Australian green roof with in-situ thermal monitoring coupled with surface temperature assessments. Field measurements were utilised to calculate the thermal buffer potential of the green roof compared to a near-identical conventional roof, over three seasons. Our findings indicated a reduction in rooftop surface temperatures up to 20 °C when ambient temperatures exceeded 40 °C, as well as improvements to heat flow of up to 55.54%. These results indicate that green roofs may contribute to the much-needed reduction in ambient city temperature to alleviate overheating and the costs associated with the urban heat island effect. Fleck, R, Westerhausen, MT, Killingsworth, N, Ball, J, Torpy, FR & Irga, PJ 2022, 'The hydrological performance of a green roof in Sydney, Australia: A tale of two towers', Building and Environment, vol. 221, pp. 109274-109274. This study describes the sister buildings Daramu house and International house in Barangaroo, Sydney (Australia's largest metropolitan city), with and without a green roof, respectively. Trace metal samples were collected from both roofs and analysed using ICP-MS to determine the bioretention potential of the green roof to remediate soluble and particulate stormwater trace metal contamination. Retention of ambient trace metal contamination by the green roof substrate was deemed significant for soluble copper and particulate zinc, chromium and copper. In addition, hydrological models (DRAINS and SWMM) were applied to predict the performance of the green roof to identify its ability to manage stormwater runoff and frequency, as well as to analyse the green roof's performance in complex surface flooding situations where storage or backwater effects occur in overflow routes and surface flows. Our results demonstrate a reduction in peak stormwater flow by 18.29 L/s (∼50%) for storms as infrequent as 1 in 5 years, and peak flow reductions up to 90% storms of lower intensities. These results are significant as it demonstrates that a green roof could remediating trace metals contamination, thus reducing the impact on aquatic environments through stormwater runoff. It also highlights their potential to reduce stormwater flow, and utilise this additional water for evapotranspiration, leading to cooler ambient temperatures. Future works should aim to quantify the remediation effect of various planted species on in-situ green roofs, as well as determine the specific retention capabilities of various substrate compositions. Flood, RL, Danzenbaker, M, Hansbro, PM, Rogers, C, Tanoi, H & Tanoi, S 2022, 'More New Zealand Storm Petrels Fregetta maoriana off Gau Island, Fiji, in May 2022', Bulletin of the British Ornithologists’ Club, vol. 142, no. 3, pp. 380-382. Focardi, A, Moore, LR, Raina, J-B, Seymour, JR, Paulsen, IT & Tetu, SG 2022, 'Plastic leachates impair picophytoplankton and dramatically reshape the marine microbiome', Microbiome, vol. 10, no. 1, p. 179. Foley, PB, Hare, DJ & Double, KL 2022, 'A brief history of brain iron accumulation in Parkinson disease and related disorders', Journal of Neural Transmission, vol. 129, no. 5-6, pp. 505-520. Foster, PS, Tay, HL & Oliver, BG 2022, 'Deficiency in the zinc transporter ZIP8 impairs epithelia renewal and enhances lung fibrosis', Journal of Clinical Investigation, vol. 132, no. 11, p. e160595. Although aging and lung injury are linked to the development of idiopathic pulmonary fibrosis (IPF), the underlying pathognomonic processes predisposing to fibrotic lesions remain largely unknown. A deficiency in the ability of type 2 alveolar epithelial cell (AEC2) progenitors to regenerate and repair the epithelia has been proposed as a critical factor. In this issue of the JCI, Liang et al. identify a deficiency in the zinc transporter SLC39A8 (ZIP8) in AEC2s and in the subsequent activation of the sirtuin SIRT1 that predisposes to decreased AEC2 renewal capacity and enhanced lung fibrosis in both IPF and aging lungs. Interestingly, the authors demonstrate the efficacy of modulating dietary zinc levels, suggesting the need for clinical trials to evaluate the therapeutic potential of dietary supplementation and the development of pharmacological modulation of the Zn/ZIP8/SIRT1 axis for treatment. Fowler, AM, Ochwada-Doyle, FA, Dowling, NA, Folpp, H, Hughes, JM, Lowry, MB, Lyle, JM, Lynch, TP, Miles, NG & Chick, RC 2022, 'Integrating recreational fishing into harvest strategies: linking data with objectives', ICES Journal of Marine Science, vol. 79, no. 2, pp. 285-307. Fowler, K, Peel, M, Saft, M, Peterson, TJ, Western, A, Band, L, Petheram, C, Dharmadi, S, Tan, KS, Zhang, L, Lane, P, Kiem, A, Marshall, L, Griebel, A, Medlyn, BE, Ryu, D, Bonotto, G, Wasko, C, Ukkola, A, Stephens, C, Frost, A, Gardiya Weligamage, H, Saco, P, Zheng, H, Chiew, F, Daly, E, Walker, G, Vervoort, RW, Hughes, J, Trotter, L, Neal, B, Cartwright, I & Nathan, R 2022, 'Explaining changes in rainfall–runoff relationships during and after Australia's Millennium Drought: a community perspective', Hydrology and Earth System Sciences, vol. 26, no. 23, pp. 6073-6120. Francis, I, Shrestha, J, Paudel, KR, Hansbro, PM, Warkiani, ME & Saha, SC 2022, 'Recent advances in lung-on-a-chip models', Drug Discovery Today, vol. 27, no. 9, pp. 2593-2602. Fröch, JE, Li, C, Chen, Y, Toth, M, Kianinia, M, Kim, S & Aharonovich, I 2022, 'Purcell Enhancement of a Cavity‐Coupled Emitter in Hexagonal Boron Nitride', Small, vol. 18, no. 2, pp. 1-6. Fronzi, M, Amos, RD, Kobayashi, R, Matsumura, N, Watanabe, K & Morizawa, RK 2022, 'Evaluation of Machine Learning Interatomic Potentials for the Properties of Gold Nanoparticles', Nanomaterials, vol. 12, no. 21, pp. 3891-3891. Fu, F, Tschitschko, B, Hutchins, DA, Larsson, ME, Baker, KG, McInnes, A, Kahlke, T, Verma, A, Murray, SA & Doblin, MA 2022, 'Temperature variability interacts with mean temperature to influence the predictability of microbial phenotypes', Global Change Biology, vol. 28, no. 19, pp. 5741-5754. Fu, L, Shi, B, Wen, S, Morsch, M, Wang, G, Zhou, Z, Mi, C, Sadraeian, M, Lin, G, Lu, Y, Jin, D & Chung, R 2022, 'Aspect Ratio of PEGylated Upconversion Nanocrystals Affects the Cellular Uptake In Vitro and In Vivo', Acta Biomaterialia, vol. 147, pp. 403-413. The central nervous system (CNS) is protected by the blood-brain barrier (BBB), which acts as a physical barrier to regulate and prevent the uptake of endogenous metabolites and xenobiotics. However, the BBB prevents most non-lipophilic drugs from reaching the CNS following systematic administration. Therefore, there is considerable interest in identifying drug carriers that can maintain the biostability of therapeutic molecules and target their transport across the BBB. In this regard, upconversion nanoparticles (UCNPs) have become popular as a nanoparticle-based solution to this problem, with the additional benefit that they display unique properties for in vivo visualization. The majority of studies to date have explored basic spherical UCNPs for drug delivery applications. However, the biophysical properties of UCNPs, cell uptake and BBB transport have not been thoroughly investigated. In this study, we described a one-pot seed-mediated approach to precisely control longitudinal growth to produce bright UCNPs with various aspect ratios. We have systematically evaluated the effects of the physical aspect ratios and PEGylation of UCNPs on cellular uptake in different cell lines and an in vivo zebrafish model. We found that PEGylated the original UCNPs can enhance their biostability and cell uptake capacity. We identify an optimal aspect ratio for UCNP uptake into several different types of cultured cells, finding that this is generally in the ratio of 2 (length/width). This data provides a crucial clue for further optimizing UCNPs as a drug carrier to deliver therapeutic agents into the CNS. STATEMENT OF SIGNIFICANCE: The central nervous system (CNS) is protected by the blood-brain barrier (BBB), which acts as a highly selective semipermeable barrier of endothelial cells to regulate and prevent the uptake of toxins and pathogens. However, the BBB prevents most non-lipophilic drugs from reaching the CNS following systematic administration. The proposed... Gaiani, G, Cucchi, F, Toldrà, A, Andree, KB, Rey, M, Tsumuraya, T, O'Sullivan, CK, Diogène, J & Campàs, M 2022, 'Electrochemical biosensor for the dual detection of Gambierdiscus australes and Gambierdiscus excentricus in field samples. First report of G. excentricus in the Balearic Islands', Science of The Total Environment, vol. 806, no. Pt 4, pp. 150915-150915. Several genera of marine dinoflagellates are known to produce bioactive compounds that affect human health. Among them, Gambierdiscus and Fukuyoa stand out for their ability to produce several toxins, including the potent neurotoxic ciguatoxins (CTXs), which accumulate through the food web. Once fishes contaminated with CTXs are ingested by humans, it can result in an intoxication named ciguatera. Within the two genera, only some species are able to produce toxins, and G. australes and G. excentricus have been highlighted to be the most abundant and toxic. Although the genera Gambierdiscus and Fukuyoa are endemic to tropical areas, their presence in subtropical and temperate regions has been recently recorded. In this work, the combined use of species-specific PCR primers for G. australes and G. excentricus modified with short oligonucleotide tails allowed the development of a multiplex detection system for these two toxin-producing species. Simultaneous detection was achieved using capture probes specific for G. australes and G. excentricus immobilized on maleimide-coated magnetic beads (MBs), separately placed on the working electrodes of a dual electrode array. Additionally, a rapid DNA extraction technique based on a portable bead beater system and MBs was developed, significantly reducing the extraction time (from several hours to 30 min). The developed technique was able to detect as low as 10 cells of both Gambierdiscus species and allowed the first detection of G. excentricus in the Balearic Islands in 8 out of the 12 samples analyzed. Finally, field samples were screened for CTXs with an immunosensor, successfully reporting 13.35 ± 0.5 pg CTX1B equiv. cell-1 in one sample and traces of toxins in 3 out of the 9 samples analyzed. These developments provide rapid and cost-effective strategies for ciguatera risk assessment, with the aim of guaranteeing seafood safety. Gaiani, G, Rey, M, Tudó, À, Rambla, M, Diogène, J, Campàs, M & Alcaraz, C 2022, 'New information about the toxicological profile of Gaio, D, Anantanawat, K, To, J, Liu, M, Monahan, L & Darling, AE 2022, 'Hackflex: low-cost, high-throughput, Illumina Nextera Flex library construction', Microbial Genomics, vol. 8, no. 1. Gaio, D, DeMaere, MZ, Anantanawat, K, Eamens, GJ, Falconer, L, Chapman, TA, Djordjevic, S & Darling, AE 2022, 'Phylogenetic diversity analysis of shotgun metagenomic reads describes gut microbiome development and treatment effects in the post-weaned pig', PLOS ONE, vol. 17, no. 6, pp. e0270372-e0270372. Gale, A, Li, C, Chen, Y, Watanabe, K, Taniguchi, T, Aharonovich, I & Toth, M 2022, 'Site-Specific Fabrication of Blue Quantum Emitters in Hexagonal Boron Nitride', ACS Photonics, vol. 9, no. 6, pp. 2170-2177. Hexagonal boron nitride (hBN) is gaining considerable attention as a solid-state host of quantum emitters from the ultraviolet to the near-infrared spectral ranges. However, the atomic structures of most of the emitters are speculative or unknown, and emitter fabrication methods typically suffer from poor reproducibility, spatial accuracy, or spectral specificity. Here, we present a robust, electron beam technique for site-specific fabrication of blue quantum emitters with a zero-phonon line at 436 nm (2.8 eV). We show that the emission intensity is proportional to electron dose and that the efficacy of the fabrication method correlates with a defect emission at 305 nm (4.1 eV). We attribute blue emitter generation to the fragmentation of carbon clusters by electron impact and show that the robustness and universality of the emitter fabrication technique are enhanced by a pre-irradiation annealing treatment. Our results provide important insights into photophysical properties and structure of defects in hBN and a framework for site-specific fabrication of quantum emitters in hBN. Ganbat, N, Altaee, A, Zhou, JL, Lockwood, T, Al-Juboori, RA, Hamdi, FM, Karbassiyazdi, E, Samal, AK, Hawari, A & Khabbaz, H 2022, 'Investigation of the effect of surfactant on the electrokinetic treatment of PFOA contaminated soil', Environmental Technology & Innovation, vol. 28, pp. 102938-102938. Gao, H, Tang, K, Xiao, J, Guo, X, Chen, W, Liu, H & Wang, G 2022, 'Recent advances in “water in salt” electrolytes for aqueous rechargeable monovalent-ion (Li+, Na+, K+) batteries', Journal of Energy Chemistry, vol. 69, pp. 84-99. Aqueous rechargeable batteries have attracted enormous attention owning to their intrinsic characteristics of non-flammability, low cost, and the superior ionic conductivity of the aqueous electrolyte. However, the narrow electrochemical stability window (1.23 V), imposed by hydrogen and oxygen evolution, constrains the overall energy density of batteries. The revolutionary “water-in-salt” electrolytes considerably expand the electrochemical stability window to 3 or even 4 volts, giving rise to a new series of high-voltage aqueous metal-ion chemistries. Herein, the recent advances in “water-in-salt” electrolytes for aqueous monovalent-ion (Li+, Na+, K+) rechargeable batteries have been systematically reviewed. Meanwhile, the corresponding reaction mechanisms, electrochemical performances and the existing challenges and opportunities are also highlighted. Gao, S, Huete, A, Kobayashi, H, Doody, TM, Liu, W, Wang, Y, Zhang, Y & Lu, X 2022, 'Simulation of solar-induced chlorophyll fluorescence in a heterogeneous forest using 3-D radiative transfer modelling and airborne LiDAR', ISPRS Journal of Photogrammetry and Remote Sensing, vol. 191, pp. 1-17. Solar-induced chlorophyll fluorescence (SIF) provides a means to estimate plant photosynthetic activities and to detect early plant stress. The accurate quantification of SIF emitted by various scene components (tree crowns and background) may significantly improve the interpretation of top-of-canopy SIF (SIFtoc) measurements made over heterogeneous canopies. To do so, a three-dimensional (3-D) canopy SIF model (FluorFLiES) was introduced by coupling the excitation-fluorescence matrices (EF-matrices) with a 3-D Monte Carlo canopy radiative transfer model (Forest Light Environmental Simulator, FLiES). A tool was developed to construct forest canopy scene components from LiDAR data and enable their simulated contributions in structurally complex forest scenes. FluorFLiES is able to quantify SIF measurements with good accuracy at both half-hourly (R2 = 0.72, RMSE = 0.26 mW m−2 sr−1 nm−1) and daily (R2 = 0.83, RMSE = 0.19 mW m−2 sr−1 nm−1) scales. This study showed that non-photosynthetic elements in tree crowns, the fractional vegetation cover (FVC), and the background (including understory vegetation and soils) had a strong influence on SIFtoc intensity. Non-photosynthetic woody material suppressed the propagation of photons within crowns, thereby decreasing SIFtoc by around 10%. The canopy background made a significant contribution to SIFtoc in the NIR region by scattering downward SIF photons upward, and the background contribution increased rapidly with decreasing FVC: SIFtoc increased two-fold from 0.15 to 0.3 mW m−2 sr−1 nm−1 when ground leaf area index increased from 0.5 to 1.5 m2/m2. The results showed that the fluorescence escape ratio (fesc), a key variable relating observed SIFtoc to photosynthesis CO2 rate, contained a contribution from the background with a magnitude of 42%, even for relatively dense forest canopies. Assuming fesc simulated by the FluorFLiES model as a reference value, this study demonstrated that the current reflectance-based... García, P, Brito, B, Alcalde-Rico, M, Munita, JM, Martínez, JRW, Olivares-Pacheco, J, Quiroz, V & Wozniak, A 2022, 'Acquisition of resistance to ceftazidime-avibactam during infection treatment in Pseudomonas aeruginosa through D179Y mutation in one of two blaKPC-2 gene copies without losing carbapenem resistance', Frontiers in Cellular and Infection Microbiology, vol. 12, p. 981792. Gardner, SG, Nitschke, MR, O’Brien, J, Motti, CA, Seymour, JR, Ralph, PJ, Petrou, K & Raina, J-B 2022, 'Increased DMSP availability during thermal stress influences DMSP-degrading bacteria in coral mucus', Frontiers in Marine Science, vol. 9. Garner, N, Ross, PM, Falkenberg, LJ, Seymour, JR, Siboni, N & Scanes, E 2022, 'Can seagrass modify the effects of ocean acidification on oysters?', Marine Pollution Bulletin, vol. 177, pp. 113438-113438. Solutions are being sought to ameliorate the impacts of anthropogenic climate change. Seagrass may be a solution to provide refugia from climate change for marine organisms. This study aimed to determine if the seagrass Zostera muelleri sub spp. capricorni benefits the Sydney rock oyster Saccostrea glomerata, and if these benefits can modify any anticipated negative impacts of ocean acidification. Future and ambient ocean acidification conditions were simulated in 52 L mesocosms at control (381 μatm) and elevated (848 μatm) CO2 with and without Z. muelleri. Oyster growth, physiology and microbiomes of oysters and seagrass were measured. Seagrass was beneficial to oyster growth at ambient pCO2, but did not positively modify the impacts of ocean acidification on oysters at elevated pCO2. Oyster microbiomes were altered by the presence of seagrass but not by elevated pCO2. Our results indicate seagrasses may not be a panacea for the impacts of climate change. Gill, RL, Collins, S, Argyle, PA, Larsson, ME, Fleck, R & Doblin, MA 2022, 'Predictability of thermal fluctuations influences functional traits of a cosmopolitan marine diatom', Proceedings of the Royal Society B: Biological Sciences, vol. 289, no. 1973, p. 20212581. Gnoatto, A, Grasselli, M & Platen, E 2022, 'Calibration to FX triangles of the 4/2 model under the benchmark approach', Decisions in Economics and Finance, vol. 45, no. 1, pp. 1-34. Goddard, BK, Becker, A, Harasti, D, Smith, JA, Subramaniam, RC & Suthers, IM 2022, 'The trophic basis of fish assemblages in temperate estuarine and coastal ecosystems', Marine Biology, vol. 169, no. 2. Godecke, E, Brogan, E, Ciccone, N, Rose, ML, Armstrong, E, Whitworth, A, Ellery, F, Holland, A, Middleton, S, Rai, T, Hankey, GJ, Cadilhac, D & Bernhardt, J 2022, 'Treatment fidelity monitoring, reporting and findings in a complex aphasia intervention trial: a substudy of the Very Early Rehabilitation in SpEech (VERSE) trial', Trials, vol. 23, no. 1, p. 501. Gonzalez de Vega, R, Lockwood, TE, Xu, X, Gonzalez de Vega, C, Scholz, J, Horstmann, M, Doble, PA & Clases, D 2022, 'Analysis of Ti- and Pb-based particles in the aqueous environment of Melbourne (Australia) via single particle ICP-MS', Analytical and Bioanalytical Chemistry, vol. 414, no. 18, pp. 5671-5681. González-Pech, RA, Hughes, DJ, Strudwick, P, Lewis, BM, Booth, DJ, Figueira, WF, Sommer, B, Suggett, DJ & Matthews, J 2022, 'Physiological factors facilitating the persistence of Pocillopora aliciae and Plesiastrea versipora in temperate reefs of south-eastern Australia under ocean warming', Coral Reefs, vol. 41, no. 4, pp. 1239-1253. Goodswen, SJ, Kennedy, PJ & Ellis, JT 2022, 'Compilation of parasitic immunogenic proteins from 30 years of published research using machine learning and natural language processing', Scientific Reports, vol. 12, no. 1. Gore‐Birch, C, Costello, O, Goolmeer, T, Moggridge, B & van Leeuwen, S 2022, 'A call to recognise and grow the Indigenous‐led stewardship of Country', Ecological Management & Restoration, vol. 23, no. S1, pp. 26-26. Gounder, P, Doo, NW, Krishnaswamy, M & Cheng, YY 2022, 'EZH2 genetic alterations in follicular and peripheral T-cell lymphoma and correlation with immunohistochemistry', Pathology, vol. 54, pp. S74-S74. Gow, I, Smith, NC, Stark, D & Ellis, J 2022, 'Laboratory diagnostics for human Leishmania infections: a polymerase chain reaction-focussed review of detection and identification methods', Parasites & Vectors, vol. 15, no. 1, p. 412. Grant, SJ, Spiegel, G, Brand, A, Kwon, KK, Heller, G, Choi, V, Wong, EK, Randle, L & Lacey, J 2022, 'Acupuncture and Reflexology for Patients Undergoing Chemotherapy: A Cohort Study', Integrative Cancer Therapies, vol. 21, pp. 153473542211230-153473542211230. Griebel, A, Metzen, D, Pendall, E, Nolan, RH, Clarke, H, Renchon, AA & Boer, MM 2022, 'Recovery from Severe Mistletoe Infection After Heat- and Drought-Induced Mistletoe Death', Ecosystems, vol. 25, no. 1, pp. 1-16. Mistletoes are emerging as important co-contributors to tree mortality across terrestrial ecosystems, particularly when infected trees are stressed by water limitations during drought. While the mechanistic effects of mistletoe infection on host physiology are reasonably well understood, quantifying the effects of mistletoe infection on stand productivity, canopy turnover and ecosystem structure remains challenging. Moreover, the potential devastating effect of mistletoe infection on host survival has distracted from the challenges that mistletoe populations are facing when increasing drought and heat stress threaten their survival in healthy populations. We coupled intensive observations of mistletoe population dynamics with measurements of host tree stem growth, canopy turnover and stand structure in a severely infected temperate eucalypt woodland to monitor how mistletoe infection alters aboveground biomass distribution and to assess ecosystem recovery from severe mistletoe infection during and after a three-year drought. We show that severe mistletoe infection reduces live standing biomass and canopy volume, with mistletoe leaves contributing up to 43% to total stand litter fall. We further identified that a mistletoe:host leaf area ratio above 60% significantly reduced basal area growth, which provides a threshold for productivity losses due to mistletoe infection in eucalypts. Yet, concurrent increases in basal area and the thickening of canopy volume indicate that host trees recover rapidly after the three-year drought combined with record summer heat nearly extinguished the mistletoe population. How common, or how widespread such dynamic changes in mistletoe population dynamics are within Australian or global ecosystems remains subject to further exploration. Griebel, A, Peters, JMR, Metzen, D, Maier, C, Barton, CVM, Speckman, HN, Boer, MM, Nolan, RH, Choat, B & Pendall, E 2022, 'Tapping into the physiological responses to mistletoe infection during heat and drought stress', Tree Physiology, vol. 42, no. 3, pp. 523-536. Grima, AJ, Clases, D, Gonzalez de Vega, R, Nitschke, MR, Goyen, S, Suggett, DJ & Camp, EF 2022, 'Species-specific elementomes for scleractinian coral hosts and their associated Symbiodiniaceae', Coral Reefs, vol. 41, no. 4, pp. 1115-1130. Gu, H, Lam, HC & Zinder, Y 2022, 'A hybrid genetic algorithm for scheduling jobs sharing multiple resources under uncertainty', EURO Journal on Computational Optimization, vol. 10, pp. 100050-100050. Gu, H, Lam, HC & Zinder, Y 2022, 'Planning rolling stock maintenance: Optimization of train arrival dates at a maintenance center', Journal of Industrial & Management Optimization, vol. 18, no. 2, pp. 747-747. Gu, H, Zhang, Y & Zinder, Y 2022, 'An efficient optimisation procedure for the Workforce Scheduling and Routing Problem: Lagrangian relaxation and iterated local search', Computers & Operations Research, vol. 144, pp. 105829-105829. The paper is concerned with the Workforce Scheduling and Routing Problem where certain service providers complete tasks at different locations. The presented optimisation procedure is an amalgamation of the iterated local search and Lagrangian relaxation. This optimisation procedure has been tested on benchmark problems from the literature, and showed superior performance in comparison with a previously published implementation of the iterated local search. Guan, M, Wang, M, Zhanghao, K, Zhang, X, Li, M, Liu, W, Niu, J, Yang, X, Chen, L, Jing, Z, Zhang, MQ, Jin, D, Xi, P & Gao, J 2022, 'Polarization modulation with optical lock-in detection reveals universal fluorescence anisotropy of subcellular structures in live cells', Light: Science & Applications, vol. 11, no. 1, p. 4. Guo, X, Gao, H, Wang, S, Yang, G, Zhang, X, Zhang, J, Liu, H & Wang, G 2022, 'MXene-Based Aerogel Anchored with Antimony Single Atoms and Quantum Dots for High-Performance Potassium-Ion Batteries', Nano Letters, vol. 22, no. 3, pp. 1225-1232. Rationally electronic structure engineering of nanocomposite electrodes shows great promise for enhancing the electrochemical performance of rechargeable batteries. Herein, we report antimony single atoms and quantum dots (∼5 nm) codecorated Ti3C2Tx MXene-based aerogels (Sb SQ@MA) for high-performance potassium-ion batteries (PIBs). We found that the atomically dispersed Sb could modify the electronic structure of the Sb/Ti3C2Tx composite, improve the charge transfer kinetics, and enhance the potassium storage capability at the heterointerfaces. Additionally, the MXene-based aerogel with rich surface functional groups and defects provides abundant anchoring sites and endows the composite reinforced structural stability and highly efficient electron transfer. The high loading of Sb (∼60.3 wt %) with short ionic transport pathways is desired potassium reservoirs. These features synergistically enhance the rate and cycling performance of the Sb SQ@MA electrodes in PIBs. This work has demonstrated an enlightening technique to tailor the interface activity of heterostructured electrodes for electrochemical applications. Guo, Z, Wang, T, Liu, H, Qiu, S, Zhang, X, Xu, Y, Langford, SJ & Sun, C 2022, 'Theoretical investigation of novel p-block metal-based electrocatalysts for nitrogen reduction reaction', Applied Surface Science, vol. 572, pp. 151441-151441. Gupta, G, Oliver, BG, Dua, K, Singh, A & MacLoughlin, R 2022, 'Preface', Microbiome in Inflammatory Lung Diseases, pp. v-vi. Haifer, C, Paramsothy, S, Kaakoush, NO, Saikal, A, Ghaly, S, Yang, T, Luu, LDW, Borody, TJ & Leong, RW 2022, 'Lyophilised oral faecal microbiota transplantation for ulcerative colitis (LOTUS): a randomised, double-blind, placebo-controlled trial', The Lancet Gastroenterology & Hepatology, vol. 7, no. 2, pp. 141-151. BACKGROUND: Faecal microbiota transplantation (FMT) delivered via colonoscopic infusion or enemas have been shown to induce remission in a proportion of patients with active ulcerative colitis. Whether orally administered FMT is effective in ulcerative colitis is unknown. We aimed to assess the efficacy of oral lyophilised FMT for the treatment of active ulcerative colitis. METHODS: A double-blind, randomised, placebo-controlled trial was conducted at two centres in Australia. Eligible patients were aged 18-75 years with active ulcerative colitis (defined as clinical and endoscopic active ulcerative colitis, with a total Mayo score of 4-10, and a Mayo endoscopic subscore ≥1). After 2 weeks of amoxicillin, metronidazole, and doxycycline, patients were randomly assigned in a 1:1 ratio to receive either oral lyophilised FMT or placebo capsules for 8 weeks, using a prespecified computer-generated randomisation list with a permuted block size of 8. The primary outcome was corticosteroid-free clinical remission with endoscopic remission or response (total Mayo score ≤2, all subscores ≤1, and ≥1 point reduction in endoscopic subscore) at week 8. At week 8, FMT responders were randomly assigned (in a 1:1 ratio, permuted block size of 8) to either continue or withdraw FMT for a further 48 weeks. Analyses were done by modified intention-to-treat, including all patients who received at least one study dose. This trial is registered with Australian New Zealand Trial Registry, number ACTRN 12619000611123; this is the final report of the trial. FINDINGS: Between May 20, 2019, and March 24, 2020, 35 patients were randomly assigned: 15 to receive FMT and 20 to receive placebo. Recruitment was terminated early due to the COVID-19 pandemic. At week 8, eight (53%) of 15 patients in the FMT group were in corticosteroid-free clinical remission with endoscopic remission or response, as were three (15%) of 20 patients in the placebo group (difference 38·3%, 95% CI 8·6-68·0; p=0·027; od... Hall, NL, Abeysuriya, KK, Jackson, M, Agnew, C, Beal, CD, Barnes, SK, Soeters, S, Mukheibir, P, Brown, S & Moggridge, B 2022, 'Safe water and sanitation in remote Indigenous communities in Australia: conditions towards sustainable outcomes', Australasian Journal of Water Resources, vol. 26, no. 2, pp. 187-198. Hallstrøm, S, Raina, J-B, Ostrowski, M, Parks, DH, Tyson, GW, Hugenholtz, P, Stocker, R, Seymour, JR & Riemann, L 2022, 'Chemotaxis may assist marine heterotrophic bacterial diazotrophs to find microzones suitable for N2 fixation in the pelagic ocean', The ISME Journal, vol. 16, no. 11, pp. 2525-2534. Hamidian, M 2022, 'Tn6553, a Tn7-family transposon encoding putative iron uptake functions found in Acinetobacter', Archives of Microbiology, vol. 204, no. 11, p. 678. Hamidian, M, Maharjan, RP, Farrugia, DN, Delgado, NN, Dinh, H, Short, FL, Kostoulias, X, Peleg, AY, Paulsen, IT & Cain, AK 2022, 'Genomic and phenotypic analyses of diverse non-clinical Acinetobacter baumannii strains reveals strain-specific virulence and resistance capacity', Microbial Genomics, vol. 8, no. 2. Hanh Duong, NM, Saerens, G, Timpu, F, Buscaglia, MT, Buscaglia, V, Morandi, A, Müller, JS, Maeder, A, Kaufmann, F, Solntsev, AS & Grange, R 2022, 'Spontaneous parametric down-conversion in bottom-up grown lithium niobate microcubes', Optical Materials Express, vol. 12, no. 9, pp. 3696-3696. Harasti, D, Brennan, M & Booth, DJ 2022, 'Assessing the Effectiveness of Conservation Stocking for the Endangered White’s Seahorse Hippocampus whitei', Frontiers in Marine Science, vol. 9, pp. 1-11. Hartigan, J, MacNamarar, S, MacNamara, S, Leslie, L & Speer, M 2022, 'Attribution and prediction of precipitation and temperature trends within the the Sydney catchment using machine learning'. Hasan, S, Kouzani, AZ, Adams, S, Long, J & Mahmud, MAP 2022, 'Comparative study on the contact-separation mode triboelectric nanogenerator', Journal of Electrostatics, vol. 116, pp. 103685-103685. Hasan, S, Kouzani, AZ, Adams, S, Long, J & Mahmud, MAP 2022, 'Recent progress in hydrogel-based sensors and energy harvesters', Sensors and Actuators A: Physical, vol. 335, pp. 113382-113382. Hasebe, K, Kendig, MD, Kaakoush, NO, Tajaddini, A, Westbrook, RF & Morris, MJ 2022, 'The influence of maternal unhealthy diet on maturation of offspring gut microbiota in rat', Animal Microbiome, vol. 4, no. 1. Hawkins, PME, Hoi, DM, Cheung, C-Y, Wang, T, Quan, D, Sasi, VM, Liu, DY, Linington, RG, Jackson, CJ, Oehlers, SH, Cook, GM, Britton, WJ, Clausen, T & Payne, RJ 2022, 'Potent Bactericidal Antimycobacterials Targeting the Chaperone ClpC1 Based on the Depsipeptide Natural Products Ecumicin and Ohmyungsamycin A', Journal of Medicinal Chemistry, vol. 65, no. 6, pp. 4893-4908. Haydon, TD, Suggett, DJ, Siboni, N, Kahlke, T, Camp, EF & Seymour, JR 2022, 'Temporal Variation in the Microbiome of Tropical and Temperate Octocorals', Microbial Ecology, vol. 83, no. 4, pp. 1073-1087. Bacterial members of the coral holobiont play an important role in determining coral fitness. However, most knowledge of the coral microbiome has come from reef-building scleractinian corals, with far less known about the nature and importance of the microbiome of octocorals (subclass Octocorallia), which contribute significantly to reef biodiversity and functional complexity. We examined the diversity and structure of the bacterial component of octocoral microbiomes over summer and winter, with a focus on two temperate (Erythropodium hicksoni, Capnella gaboensis; Sydney Harbour) and two tropical (Sinularia sp., Sarcophyton sp.; Heron Island) species common to reefs in eastern Australia. Bacterial communities associated with these octocorals were also compared to common temperate (Plesiastrea versipora) and tropical (Acropora aspera) hard corals from the same reefs. Using 16S rRNA amplicon sequencing, bacterial diversity was found to be heterogeneous among octocorals, but we observed changes in composition between summer and winter for some species (C. gaboensis and Sinularia sp.), but not for others (E. hicksoni and Sarcophyton sp.). Bacterial community structure differed significantly between all octocoral species within both the temperate and tropical environments. However, on a seasonal basis, those differences were less pronounced. The microbiomes of C. gaboensis and Sinularia sp. were dominated by bacteria belonging to the genus Endozoicomonas, which were a key conserved feature of their core microbiomes. In contrast to previous studies, our analysis revealed that Endozoicomonas phylotypes are shared across different octocoral species, inhabiting different environments. Together, our data demonstrates that octocorals harbour a broad diversity of bacterial partners, some of which comprise 'core microbiomes' that potentially impart important functional roles to their hosts. He, F, Mahmud, MAP, Kouzani, AZ, Anwar, A, Jiang, F & Ling, SH 2022, 'An Improved SLIC Algorithm for Segmentation of Microscopic Cell Images.', Biomed. Signal Process. Control., vol. 73, pp. 103464-103464. He, J, Feng, P, Wang, B, Zhuang, W, Zhang, Y, Liu, DL, Cleverly, J, Huete, A & Yu, Q 2022, 'Centennial Annual Rainfall Pattern Changes Show an Increasing Trend with Higher Variation over Northern Australia', Journal of Hydrometeorology, vol. 23, no. 8, pp. 1333-1349. Hegarty, A, Stewart, J & Gladstone, W 2022, 'Geographical variation in age and growth of the endemic Hem, S, Jarocki, VM, Baker, DJ, Charles, IG, Drigo, B, Aucote, S, Donner, E, Burnard, D, Bauer, MJ, Harris, PNA, Wyrsch, ER & Djordjevic, SP 2022, 'Genomic analysis of Elizabethkingia species from aquatic environments: Evidence for potential clinical transmission', Current Research in Microbial Sciences, vol. 3, pp. 100083-100083. Hem, S, Wyrsch, ER, Drigo, B, Baker, DJ, Charles, IG, Donner, E, Jarocki, VM & Djordjevic, SP 2022, 'Genomic Analysis of Carbapenem-Resistant Comamonas in Water Matrices: Implications for Public Health and Wastewater Treatments', Applied and Environmental Microbiology, vol. 88, no. 13, p. e0064622. Herdean, A, Sutherland, DL & Ralph, PJ 2022, 'Phenoplate: An innovative method for assessing interacting effects of temperature and light on non-photochemical quenching in microalgae under chemical stress', New Biotechnology, vol. 66, pp. 89-96. Heywood, Z, Mallinson, J, Galli, E, Acharya, S, Bose, S, Arnold, M, Bones, P & Brown, S 2022, 'Self-organized nanoscale networks: are neuromorphic properties conserved in realistic device geometries?', Neuromorphic Computing and Engineering, vol. 2, no. 2, pp. 024009-024009. Hitchcock, JN 2022, 'Microplastics can alter phytoplankton community composition', Science of The Total Environment, vol. 819, pp. 153074-153074. Microplastic pollution is a growing concern globally due to the risks they may pose to ecological communities. Phytoplankton are key ecological community in aquatic ecosystems providing both energy to food webs and have critical roles in ecosystem functions such as carbon cycling. To date studies on how microplastics effect phytoplankton have largely been limited to laboratory exposure studies using monocultures of algae. It remains unknown how the structure of phytoplankton communities will be influenced by growing microplastic pollution. The aim of this study was to determine how different concentrations microplastic fibers influence phytoplankton community structure. Two six-day microcosm studies were conducted testing the response of the phytoplankton community to low, medium, and high microplastics concentrations on the Georges River, Australia. The results showed the highest concentrations of microplastics significantly altered the structure phytoplankton community. These differences were largely driven by increased abundances of cyanobacteria taxa Aphanocapsa and Pseudanabaena, and to a lesser extent reduced abundances of taxa including Crucigenia and Chlamydmonas. There were no significant differences between controls and the low and medium treatments in either experiment. The high concentrations used in this experiment whilst likely rare in the environment are environmentally relevant and equivalent to some of more polluted ecosystems. The results highlight the potential risk to food webs and ecosystem functioning through altering the dynamics of primary production and provide evidence for further study examining the response of ecological communities to microplastics in the environment. Ho Shon, I, Hennessy, T, Guille, J, Gotsbacher, MP, Lay, AJ, McBride, B, Codd, R & Hogg, PJ 2022, 'A first-in-human study of [68Ga]Ga-CDI: a positron emitting radiopharmaceutical for imaging tumour cell death', European Journal of Nuclear Medicine and Molecular Imaging, vol. 49, no. 12, pp. 4037-4047. Holt, SA, Oliver, TE & Nelson, ARJ 2022, 'Using refnx to Model Neutron Reflectometry Data from Phospholipid Bilayers', Methods Mol Biol, vol. 2402, pp. 179-197. Neutron reflectometry has emerged as a powerful method for studying the structure of thin films in contact with solution at sub-molecular spatial resolution (Penfold and Thomas, J Phys Condens Matter 2:1369-1412, 1990). This type of experiment is undertaken at large international central facilities and experience in data analysis and interpretation is not always available 'locally'. Here, we describe the application of the refnx software suite (Nelson and Prescott, J Appl Crystallogr 52:193-200, 2019) to the analysis of a single phospholipid bilayer deposited at a silicon/buffer interface. The data is modeled such that the fitted parameters are readily interpretable by researchers working with lipid bilayers. Honsell, G, Gaiani, G, Hirama, M, Pelin, M, Tubaro, A, Tsumuraya, T & Campàs, M 2022, 'Cell immunolocalization of ciguatoxin-like compounds in the benthic dinoflagellate Gambierdiscus australes M. Chinain & M.A. Faust by confocal microscopy', Harmful Algae, vol. 120, pp. 102353-102353. Dinoflagellates of the genera Gambierdiscus and Fukuyoa are able to produce potent neurotoxins like ciguatoxins (CTXs), which, after biooxidation in fish, are responsible for ciguatera intoxication. An isolate of G. australes from the Canary Islands, that revealed the presence of CTX-like compounds by immunosensing tools, was studied by immunocytochemistry to localize intracellular CTX-like compounds, using 8H4 monoclonal antibody that specifically recognizes the right wing of CTX1B and CTX3C analogues. Confocal microscopy observations of immunostained whole cells revealed a strong positive reaction on cell surface and all along the cell outline, while no reaction was detected inside the cells, probably because the antibody was not able to pass through thecal plates. Cell sections showed a positive antibody staining not only on thecal plates, but also inside cytoplasm, with numerous small dots and larger tubule-like reticulate structures. Small fluorescent dots were detected also on the nuclear surface. These observations indicate that CTX-like compounds are present in G. australes cytoplasm, and then are, at least in part, released to cover the cell surface. Hoque, MM, Noorian, P, Espinoza-Vergara, G, Manuneedhi Cholan, P, Kim, M, Rahman, MH, Labbate, M, Rice, SA, Pernice, M, Oehlers, SH & McDougald, D 2022, 'Adaptation to an amoeba host drives selection of virulence-associated traits in Vibrio cholerae', The ISME Journal, vol. 16, no. 3, pp. 856-867. Horder, J, White, SJU, Gale, A, Li, C, Watanabe, K, Taniguchi, T, Kianinia, M, Aharonovich, I & Toth, M 2022, 'Coherence Properties of Electron-Beam-Activated Emitters in Hexagonal Boron Nitride Under Resonant Excitation', Physical Review Applied, vol. 18, no. 6. Two-dimensional (2D) materials are becoming increasingly popular as a platform for studies of quantum phenomena and for the production of prototype quantum technologies. Quantum emitters in 2D materials can host two-level systems that can act as qubits for quantum information processing. Here, we characterize the behavior of position-controlled quantum emitters in hexagonal boron nitride at cryogenic temperatures. Over two dozen sites, we observe an ultranarrow distribution of the zero phonon line at approximately 436 nm, together with strong linearly polarized emission. We employ resonant excitation to characterize the emission lineshape and find spectral diffusion and phonon broadening contribute to linewidths in the range 1-2 GHz. Rabi oscillations are observed at a range of resonant excitation powers, and under 1-μW excitation a coherent superposition is maintained up to 0.90 ns. Our results are promising for future employment of quantum emitters in h-BN for scalable quantum technologies. Hortle, E, Tran, VLT, Wright, K, Fontaine, ARM, Pinello, N, O’Rourke, MB, Wong, JJ-L, Hansbro, PM, Britton, WJ & Oehlers, SH 2022, 'OXSR1 inhibits inflammasome activation by limiting potassium efflux during mycobacterial infection', Life Science Alliance, vol. 5, no. 9, pp. e202201476-e202201476. Hossain, KR, Escobar Bermeo, JD, Warton, K & Valenzuela, SM 2022, 'New Approaches and Biomarker Candidates for the Early Detection of Ovarian Cancer', Frontiers in Bioengineering and Biotechnology, vol. 10, p. 819183. Hossain, MJ, Kendig, MD, Letton, ME, Morris, MJ & Arnold, R 2022, 'Peripheral Neuropathy Phenotyping in Rat Models of Type 2 Diabetes Mellitus: Evaluating Uptake of the Neurodiab Guidelines and Identifying Future Directions', Diabetes & Metabolism Journal, vol. 46, no. 2, pp. 198-221. Hossain, MR, Tasmin, N, Golder, S & Mahmud, MAP 2022, 'Environment and object design for 3D simulation in context of commercial vehicles', International Journal on Interactive Design and Manufacturing (IJIDeM), vol. 16, no. 3, pp. 969-985. Hossain, SI, Seppelt, M, Nguyen, N, Stokes, C & Deplazes, E 2022, 'The role of ion-lipid interactions and lipid packing in transient defects caused by phenolic compounds', Biophysical Journal, vol. 121, no. 18, pp. 3520-3532. Hosseinkhani, N, McCauley, JI & Ralph, PJ 2022, 'Key challenges for the commercial expansion of ingredients from algae into human food products', Algal Research, vol. 64, pp. 102696-102696. Hou, J, Fang, L, Wang, X, Gao, H & Wang, G 2022, 'Spatially confined magnesiothermic reduction induced uniform mesoporous hollow silicon carbide nanospheres for high-performance supercapacitors', Chemical Communications, vol. 58, no. 89, pp. 12455-12458. Hou, J, Yang, M, Sun, B & Wang, G 2022, 'Improvement Strategies toward Stable Lithium‐Metal Anodes for High‐Energy Batteries', Batteries & Supercaps, vol. 5, no. 12. Hou, W, Feng, P, Guo, X, Wang, Z, Bai, Z, Bai, Y, Wang, G & Sun, K 2022, 'Catalytic Mechanism of Oxygen Vacancies in Perovskite Oxides for Lithium–Sulfur Batteries', Advanced Materials, vol. 34, no. 26, pp. e2202222-2202222. Howe, ENW, Chang, V-VT, Wu, X, Fares, M, Lewis, W, Macreadie, LK & Gale, PA 2022, 'Halide-selective, proton-coupled anion transport by phenylthiosemicarbazones', Biochimica et Biophysica Acta (BBA) - Biomembranes, vol. 1864, no. 2, pp. 183828-183828. Phenylthiosemicarbazones (PTSCs) are proton-coupled anion transporters with pH-switchable behaviour known to be regulated by an imine protonation equilibrium. Previously, chloride/nitrate exchange by PTSCs was found to be inactive at pH 7.2 due to locking of the thiourea anion binding site by an intramolecular hydrogen bond, and switched ON upon imine protonation at pH 4.5. The rate-determining process of the pH switch, however, was not examined. We here develop a new series of PTSCs and demonstrate their conformational behaviour by X-ray crystallographic analysis and pH-switchable anion transport properties by liposomal assays. We report the surprising finding that the protonated PTSCs are extremely selective for halides over oxyanions in membrane transport. Owing to the high chloride over nitrate selectivity, the pH-dependent chloride/nitrate exchange of PTSCs originates from the rate-limiting nitrate transport process being inhibited at neutral pH. Howlett, L, Camp, EF, Edmondson, J, Edmondson, J, Agius, T, Hosp, R, Coulthard, P, Edmondson, S & Suggett, DJ 2022, 'Adoption of coral propagation and out-planting via the tourism industry to advance site stewardship on the northern Great Barrier Reef', Ocean & Coastal Management, vol. 225, pp. 106199-106199. Htet, CS, Manjón-Sanz, AM, Liu, J, Kong, J, Marlton, FP, Nayak, S, Jørgensen, MRV & Pramanick, A 2022, 'Effect of Local Structural Distortions on Antiferroelectric–Ferroelectric Phase Transition in Dilute Solid Solutions of KxNa1–xNbO3', Inorganic Chemistry, vol. 61, no. 50, pp. 20277-20287. Htet, CS, Nayak, S, Manjón-Sanz, A, Liu, J, Kong, J, Sørensen, DR, Marlton, F, Jørgensen, MRV & Pramanick, A 2022, 'Atomic structural mechanism for ferroelectric-antiferroelectric transformation in perovskite Sodium niobate (NaNbO3 or NN) is described as 'the most complex perovskite system,'which exhibits transitions between, as well as coexistence of, several ferroelectrics (FE) and antiferroelectric (AFE) phases at different temperatures. Recently, solid solutions of NN with stabilized AFE phases(s) have gained attention for energy-related applications, such as high-density energy storage and electrocaloric cooling. A better understanding of the atomic mechanisms responsible for AFE/FE phase transitions in NaNbO3 can enable a more rational design of its solid-solution systems with tunable functional properties. Here, we have investigated changes in the average and local atomic structure of NN using a combination of x-ray/neutron diffraction and neutron pair-distribution function (PDF) analyses. The Rietveld refinement of the x-ray/neutron-diffraction patterns indicates a coexistence of the FE Q (P21ma) and AFE P (Pbma) phases in the temperature range of 300K≤T≤615K, while PDF analysis indicated that the local structure (r<8Å) is better described by a P21ma symmetry. Above 615 K, the average structure transitions to an AFE R phase (Pmmn or Pnma), while PDF analysis shows an increased disordering of the octahedral distortions and Na displacements at the local scale. These results indicate that the average P/Q/R phase transitions in NN can be described as a result of complex ordering of distorted octahedral tilts at the nanoscale and off-centered displacements of the Na atoms. Hu, B, Bao, G, Xu, X & Yang, K 2022, 'Topical hemostatic materials for coagulopathy', Journal of Materials Chemistry B, vol. 10, no. 12, pp. 1946-1959. Huang, C, Yang, Z & Li, J 2022, 'An iterative learning control with learnable band extension for the nanopositioning stage', Assembly Automation, vol. 42, no. 5, pp. 677-685. Huang, G, Zhu, Y, Wen, S, Mei, H, Liu, Y, Wang, D, Maddahfar, M, Su, QP, Lin, G, Chen, Y & Jin, D 2022, 'Single Small Extracellular Vesicle (sEV) Quantification by Upconversion Nanoparticles', Nano Letters, vol. 22, no. 9, pp. 3761-3769. Cancer-derived small extracellular vesicles (sEVs) are potential circulating biomarkers in liquid biopsies. However, their small sizes, low abundance, and heterogeneity in molecular makeups pose major technical challenges for detecting and characterizing them quantitatively. Here, we demonstrate a single-sEV enumeration platform using lanthanide-doped upconversion nanoparticles (UCNPs). Taking advantage of the unique optical properties of UCNPs and the background-eliminating property of total internal reflection fluorescence (TIRF) imaging technique, a single-sEV assay recorded a limit of detection 1.8 × 106 EVs/mL, which was nearly 3 orders of magnitude lower than the standard enzyme-linked immunosorbent assay (ELISA). Its specificity was validated by the difference between EpCAM-positive and EpCAM-negative sEVs. The accuracy of the UCNP-based single-sEV assay was benchmarked with immunomagnetic-beads flow cytometry, showing a high correlation (R2> 0.99). The platform is suitable for evaluating the heterogeneous antigen expression of sEV and can be easily adapted for biomarker discoveries and disease diagnosis. Huang, J, Cui, L, Natarajan, M, Barone, PW, Wolfrum, JM, Lee, YH, Rice, SA & Springs, SL 2022, 'The ratio of nicotinic acid to nicotinamide as a microbial biomarker for assessing cell therapy product sterility', Molecular Therapy - Methods & Clinical Development, vol. 25, pp. 410-424. Controlling microbial risks in cell therapy products (CTPs) is important for product safety. Here, we identified the nicotinic acid (NA) to nicotinamide (NAM) ratio as a biomarker that detects a broad spectrum of microbial contaminants in cell cultures. We separately added six different bacterial species into mesenchymal stromal cell and T cell culture and found that NA was uniquely present in these bacteria-contaminated CTPs due to the conversion from NAM by microbial nicotinamidases, which mammals lack. In cells inoculated with 1 × 104 CFUs/mL of different microorganisms, including USP <71> defined organisms, the increase in NA to NAM ratio ranged from 72 to 15,000 times higher than the uncontaminated controls after 24 h. Importantly, only live microorganisms caused increases in this ratio. In cells inoculated with 18 CFUs/mL of Escherichia coli, 20 CFUs/mL of Bacillus subtilis, and 10 CFUs/mL of Candida albicans, significant increase of NA to NAM ratio was detected using LC-MS after 18.5, 12.5, and 24.5 h, respectively. In contrast, compendial sterility test required >24 h to detect the same amount of these three organisms. In conclusion, the NA to NAM ratio is a useful biomarker for detection of early-stage microbial contaminations in CTPs. Huang, J, Lai, JHC, Tse, K, Cheng, GWY, Liu, Y, Chen, Z, Han, X, Chen, L, Xu, J & Chan, KWY 2022, 'Deep neural network based CEST and AREX processing: Application in imaging a model of Alzheimer’s disease at 3 T', Magnetic Resonance in Medicine, vol. 87, no. 3, pp. 1529-1545. Huang, T, Huang, X, Li, H, Qi, J, Wang, N, Xu, Y, Zeng, Y, Xiao, X, Liu, R, Chan, YL, Oliver, BG, Yi, C, Li, D & Chen, H 2022, 'Maternal Cigarette Smoke Exposure Exaggerates the Behavioral Defects and Neuronal Loss Caused by Hypoxic-Ischemic Brain Injury in Female Offspring', Frontiers in Cellular Neuroscience, vol. 16, p. 818536. Huang, X, Luu, LDW, Jia, N, Zhu, J, Fu, J, Xiao, F, Liu, C, Li, S, Shu, G, Hou, J, Kang, M, Zhang, D, Xu, Y, Wang, Y, Cui, X, Lai, J, Li, J & Tai, J 2022, 'Multi-Platform Omics Analysis Reveals Molecular Signatures for Pathogenesis and Activity of Systemic Lupus Erythematosus', Frontiers in Immunology, vol. 13, pp. 1-15. Huber, E, Davila, YC & Thomson, ACG 2022, 'Designing intensive mode science subjects: improving the student and teacher experience', Journal of University Teaching and Learning Practice, vol. 19, no. 5. Intensive mode delivery (IMD) of subjects and courses offer a flexible option for today’s diverse student body, many of whom juggle work and carer responsibilities alongside study. However, little focus has been placed on the detailed design of IMD for different teaching roles. Responding to a call for science specific data, we investigated students’ and staff perceptions of learning and teaching in IMD undergraduate science subjects. Using data collected via student surveys and teacher interviews, we present our findings through the transition pedagogy framework which will help learning designers and teachers make quality design decisions. We found students and staff identified positive aspects of IMD, such as accelerating progression, high engagement, and smaller class size. The challenges with IMD include the intensity associated with workload. In most subjects, student attainment was higher in IMD compared to standard delivery over a semester. By comparing the perceptions to achievements, we examine the implications for designing positive and effective student learning experiences for IMD in science subjects. Practitioner Notes 1. Institutions need to invest time and resources into supporting staff to redesign their units for intensive mode delivery (IMD) – you cannot simply transpose from a standard mode to IMD. 2. Undergraduate science students’ grade distributions display complex relationships but are significantly different for IMD compared to standard mode. 3. Intensive mode assessment design needs to acknowledge that students often choose to study in this mode to accelerate their degree program. 4. Smaller class sizes are associated with IMD and staff can leverage this to create more personal engagement opportunities with students. 5. We provide a set of practical guidelines for both the lecturer and the tutor specifically for the design and delivery of IMD subjects in the sciences. Hughes, DJ, Alexander, J, Cobbs, G, Kühl, M, Cooney, C, Pernice, M, Varkey, D, Voolstra, CR & Suggett, DJ 2022, 'Widespread oxyregulation in tropical corals under hypoxia', Marine Pollution Bulletin, vol. 179, pp. 113722-113722. Hughes, DJ, Raina, J-B, Nielsen, DA, Suggett, DJ & Kühl, M 2022, 'Disentangling compartment functions in sessile marine invertebrates', Trends in Ecology & Evolution, vol. 37, no. 9, pp. 740-748. Sessile invertebrates are frequently sampled and processed whole for downstream analyses. However, their apparent structural simplicity is deceptive as these organisms often harbour discrete compartments. These compartments have physicochemical conditions that differ markedly from neighbouring tissues, and that have likely evolved to support specific functions. Here, we argue that such compartments should be specifically targeted when characterising sessile invertebrate biology and we use the coral gastrovascular cavity to support our argument. This complex compartment displays steep and dynamic chemical gradients, harbours distinct microorganisms, and presumably plays a key role in coral biology. Disentangling the functions played by (and amongst) compartments will likely provide transformative insight into the biology of sessile invertebrates and their future under environmental change. Hughes, DM, García-Fiñana, M & Wand, MP 2022, 'Fast approximate inference for multivariate longitudinal data', Biostatistics, vol. 24, no. 1, pp. 177-192. Hughes, JM, Meadows, NM, Stewart, J, Booth, DJ & Fowler, AM 2022, 'Movement patterns of an iconic recreational fish species, mulloway (Argyrosomus japonicus), revealed by cooperative citizen-science tagging programs in coastal eastern Australia', Fisheries Research, vol. 247, pp. 106179-106179. Huo, J, Shen, Z, Cao, X, Li, L, Zhao, Y, Liu, H & Wang, G 2022, 'Macro/Micro‐Environment Regulating Carbon‐Supported Single‐Atom Catalysts for Hydrogen/Oxygen Conversion Reactions', Small, vol. 18, no. 32, pp. e2202394-2202394. Hurtado-McCormick, V, Commault, A, Herdean, A, Price, S, Pernice, M & Ralph, P 2022, 'Generation of Synechocystis sp. PCC 6803 mutant with enhanced laccase-like activity', Bioresource Technology Reports, vol. 20, pp. 101266-101266. Cyanobacteria offer a good alternative to fungi for laccase production at industrial scales. Random mutagenesis approaches with ethyl methanesulfonate were used in combination with enzymatic assays screenings to select a mutant of Synechocystis sp., A2, with enhanced extracellular laccase-like activity. Anthraquinone dye decolourisation assay revealed 7 % enhanced decolourisation in A2 relative to wild type after 24 h. Comparison of the microbiome composition, structure and richness of the wild type and A2 strains confirmed that the improved traits were due to the mutation(s) and not the associated bacteria. The newly isolated Synechocystis mutant is the first example of successful random mutagenesis of cyanobacteria for laccase production. Attempts to characterise the biochemical reaction and putative laccase in A2 strain were unsuccessful but will be the subject of further research. This study suggests that random mutagenesis as a powerful approach for generating cyanobacterial strains with enhanced laccase-like activity for prospective commercial applications. Huston, WM, Lawrence, A, Wee, BA, Thomas, M, Timms, P, Vodstrcil, LA, McNulty, A, McIvor, R, Worthington, K, Donovan, B, Phillips, S, Chen, MY, Fairley, CK & Hocking, JS 2022, 'Repeat infections with chlamydia in women may be more transcriptionally active with lower responses from some immune genes', Frontiers in Public Health, vol. 10, p. 1012835. Hwang, J, Strange, N, Mazraani, R, Phillips, MJ, Gamble, AB, Huston, WM & Tyndall, JDA 2022, 'Design, synthesis and biological evaluation of P2-modified proline analogues targeting the HtrA serine protease in Chlamydia', European Journal of Medicinal Chemistry, vol. 230, pp. 114064-114064. High temperature requirement A (HtrA) serine proteases have emerged as a novel class of antibacterial target, which are crucial in protein quality control and are involved in the pathogenesis of a wide array of bacterial infections. Previously, we demonstrated that HtrA in Chlamydia is essential for bacterial survival, replication and virulence. Here, we report a new series of proline (P2)-modified inhibitors of Chlamydia trachomatis HtrA (CtHtrA) developed by proline ring expansion and Cγ-substitutions. The structure-based drug optimization process was guided by molecular modelling and in vitro pharmacological evaluation of inhibitory potency, selectivity and cytotoxicity. Compound 25 from the first-generation 4-substituted proline analogues increased antiCtHtrA potency and selectivity over human neutrophil elastase (HNE) by approximately 6- and 12-fold, respectively, relative to the peptidic lead compound 1. Based on this compound, second-generation substituted proline residues containing 1,2,3-triazole moieties were synthesized by regioselective azide-alkyne click chemistry. Compound 49 demonstrated significantly improved antichlamydial activity in whole cell assays, diminishing the bacterial infectious progeny below the detection limit at the lowest dose tested. Compound 49 resulted in approximately 9- and 22-fold improvement in the inhibitory potency and selectivity relative to 1, respectively. To date, compound 49 is the most potent HtrA inhibitor developed against Chlamydia spp. Ibrahim, I, Hossain, SM, Seo, DH, McDonagh, A, Foster, T, Shon, HK & Tijing, L 2022, 'Insight into the role of polydopamine nanostructures on nickel foam-based photothermal materials for solar water evaporation', Separation and Purification Technology, vol. 293, pp. 121054-121054. Ibrahim, I, Seo, DH, Park, MJ, Angeloski, A, McDonagh, A, Bendavid, A, Shon, HK & Tijing, L 2022, 'Highly stable gold nanolayer membrane for efficient solar water evaporation under a harsh environment', Chemosphere, vol. 299, pp. 134394-134394. Imran, M, Jha, LA, Hasan, N, Shrestha, J, Pangeni, R, Parvez, N, Mohammed, Y, Jha, SK & Paudel, KR 2022, '“Nanodecoys” - Future of drug delivery by encapsulating nanoparticles in natural cell membranes', International Journal of Pharmaceutics, vol. 621, pp. 121790-121790. Imran, M, Paudel, KR, Jha, SK, Hansbro, PM, Dua, K & Mohammed, Y 2022, 'Dressing Multifunctional Nanoparticles with Natural Cell-Derived Membranes for Superior Chemotherapy', Nanomedicine, vol. 17, no. 10, pp. 665-670. Inomura, K, Masuda, T, Eichner, M, Rabouille, S, Zavřel, T, Červený, J, Vancová, M, Bernát, G, Armin, G, Claquin, P, Kotabová, E, Stephan, S, Suggett, DJ, Deutsch, C & Prášil, O 2022, 'Erratum to “Quantifying Cyanothece growth under DIC limitation” [Comput. Struct. Biotechnol. J. 19 (2021) 6456–6464]', Computational and Structural Biotechnology Journal, vol. 20, pp. 385-385. [This corrects the article DOI: 10.1016/j.csbj.2021.11.036.]. Iqbal, S, Flux, C, Briggs, DA, Deplazes, E, Long, J, Skrzypek, R, Rothnie, A, Kerr, ID & Callaghan, R 2022, 'Vinca alkaloid binding to P-glycoprotein occurs in a processive manner', Biochimica et Biophysica Acta (BBA) - Biomembranes, vol. 1864, no. 10, pp. 184005-184005. Irga, PJ, Fleck, R, Arsenteva, E & Torpy, FR 2022, 'Biosolar green roofs and ambient air pollution in city centres: Mixed results', Building and Environment, vol. 226, pp. 109712-109712. Islam, MZ, Hossain, SI, Deplazes, E & Saha, SC 2022, 'Concentration-dependent cortisone adsorption and interaction with model lung surfactant monolayer', Molecular Simulation, vol. 48, no. 18, pp. 1627-1638. Corticosteroids are drugs used to treat inflammatory conditions. In the case of lung diseases, corticosteroids can be administered by inhalation. The main barrier for inhaled particles is the lung surfactant monolayer (LSM) that lines the alveolar air–water interface and reduces surface tension during breathing. In this study, we use coarse-grained molecular dynamics simulations to study the concentration-dependent interaction of cortisone with an LSM composed of neutral and negatively charged phospholipids, cholesterol, and surfactant proteins. Simulations were carried out at surface tensions mimicking inhalation and exhalation conditions and different compressibilities. In-depth analysis shows that cortisone causes a concentration-dependent expansion of the monolayer that at high surface tension and high drug concentrations results in the monolayer collapsing. This instability is associated with the accumulation of drugs and surfactant proteins that prevent adsorption into the monolayer. Our findings help to improve the understanding of how corticosteroids alter lung surfactants structure and assist efforts to improve drug adsorption. Islam, MZ, Hossain, SI, Deplazes, E & Saha, SC 2022, 'The steroid mometasone alters protein containing lung surfactant monolayers in a concentration-dependent manner', Journal of Molecular Graphics and Modelling, vol. 111, pp. 108084-108084. Mometasone is an investigational anti-inflammatory steroidal drug to treat inflammation via pulmonary administration. For steroid drugs to be effective they need to be adsorbed by lung surfactants, a thin monolayer at the air-water interface in alveoli that reduces surface tension. Information on the molecular-level interactions of the drug with lung surfactants is useful to understand the mechanism of adsorption. In this study, we use coarse-grained molecular dynamics simulation to understand the concentration-dependent effect of mometasone on a lung surfactant monolayer (LSM) composed of lipids and surfactant proteins, under two different breathing conditions (exhalation, at surface tension 0 mNm-1 and inhalation, surface tension 20-25 mNm-1). A series of fixed-APL and fixed-surface tension simulations were used to demonstrate that in the absence of drugs, the model LSM reproduces the surface tensions for the compressed and expanded states, as well as compressibility at different surface tensions. In-depth analysis of simulations of a LSM in the presence of five different drug concentrations shows that mometasone alters the structure and dynamics of the LSM in a concentration-dependent manner. Mometasone induces a collapse in the monolayer that is affected by the surfactant protein and surface tension. Overall, these findings suggest that the surfactant proteins, surface tension and drug concentration are all critical components affecting monolayer stability and drug adsorption. The outcomes of this study may be beneficial for a more in-depth understanding of how mometasone is adsorbed by lung surfactants. Islam, MZ, Hossain, SI, Deplazes, E, Luo, Z & Saha, SC 2022, 'The concentration-dependent effect of hydrocortisone on the structure of model lung surfactant monolayer by using an in silico approach', RSC Advances, vol. 12, no. 51, pp. 33313-33328. Islam, MZ, Krajewska, M, Hossain, SI, Prochaska, K, Anwar, A, Deplazes, E & Saha, SC 2022, 'Concentration-Dependent Effect of the Steroid Drug Prednisolone on a Lung Surfactant Monolayer', Langmuir, vol. 38, no. 14, pp. 4188-4199. The lung surfactant monolayer (LSM) is the main barrier for particles entering the lung, including steroid drugs used to treat lung diseases. The present study combines Langmuir experiments and coarse-grained (CG) molecular dynamics simulations to investigate the concentration-dependent effect of steroid drug prednisolone on the structure and morphology of a model LSM. The surface pressure-area isotherms for the Langmuir monolayers reveal a concentration-dependent decrease in area per lipid (APL). Results from simulations at a fixed surface tension, representing inhalation and exhalation conditions, suggest that at high drug concentrations, prednisolone induces a collapse of the LSM, which is likely caused by the inability of the drug to diffuse into the bilayer. Overall, the monolayer is most susceptible to drug-induced collapse at surface tensions representing exhalation conditions. The presence of cholesterol also exacerbates the instability. The findings of this investigation might be helpful for better understanding the interaction between steroid drug prednisolone and lung surfactants in relation to off-target effects. Iwasaki, K, Szabó, M, Tamburic, B, Evenhuis, C, Zavafer, A, Kuzhiumparambil, U & Ralph, P 2022, 'Investigating the impact of light quality on macromolecular of', Functional Plant Biology, vol. 49, no. 6, pp. 554-564. James, J, Byrne, AMP, Goharriz, H, Golding, M, Cuesta, JMA, Mollett, BC, Shipley, R, M. McElhinney, L, Fooks, AR & Brookes, SM 2022, 'Infectious droplet exposure is an inefficient route for SARS-CoV-2 infection in the ferret model', Journal of General Virology, vol. 103, no. 11. Jana, A, Bhattacharjee, A, Das, SS, Srivastava, A, Choudhury, A, Bhattacharjee, R, De, S, Perveen, A, Iqbal, D, Gupta, PK, Jha, SK, Ojha, S, Singh, SK, Ruokolainen, J, Jha, NK, Kesari, KK & Ashraf, GM 2022, 'Molecular Insights into Therapeutic Potentials of Hybrid Compounds Targeting Alzheimer’s Disease', Molecular Neurobiology, vol. 59, no. 6, pp. 3512-3528. Jansen, MI, Broome, ST & Castorina, A 2022, 'Targeting the neurological comorbidities of multiple sclerosis: the beneficial effects of VIP and PACAP neuropeptides', Journal of Integrative Neuroscience, vol. 21, no. 1, pp. 033-033. Javanshir, A, Nguyen, TT, Mahmud, MAP & Kouzani, AZ 2022, 'Advancements in Algorithms and Neuromorphic Hardware for Spiking Neural Networks', Neural Computation, vol. 34, no. 6, pp. 1289-1328. Jena, R, Vishwas, S, Kumar, R, Kaur, J, Khursheed, R, Gulati, M, Singh, TG, Vanathi, BM, Alam, A, Kumar, B, Chaitanya, MVNL, Gupta, S, Negi, P, Pandey, NK, Bhatt, S, Gupta, G, Chellappan, DK, Oliver, BG, Dua, K & Singh, SK 2022, 'Treatment strategies for HIV infection with emphasis on role of CRISPR/Cas9 gene: Success so far and road ahead', European Journal of Pharmacology, vol. 931, pp. 175173-175173. Advances in biotechnology have led to improving human health with number of novel approaches to mitigate life-threatening diseases such as human immunodeficiency virus (HIV) infection, cancer, and neurodegenerative diseases. In the case of HIV, the damage caused by the retrovirus to the immune system leads to opportunistic infection as well as an elevated risk of autoimmune disease and cancer. Furthermore, clinical symptoms associated with the virus itself may arise. Antiretroviral drug therapy using reverse transcriptase inhibitors, protease inhibitors, fusion inhibitor, chemokine receptor 5 antagonist and integrase strand transfer inhibitors have shown promising results in treating HIV infection and available in market in the form of various dosage forms. However, they are unable to completely cure the disease because of complexity in pathogenesis of HIV. In addition, these drugs have some limitations of poor solubility, permeability or, poor receptor binding capacity. To overcome these drawbacks, many novel drug delivery systems for the drugs belonging to above mentioned categories have been developed. The possibility of treating HIV infection using CRISPR-Cas9 gene editing has been found in 2015. This provided a new area of research to the scientists who are working towards alternative treatment strategies for HIV infections. The present article describes about various treatment strategies used to treat HIV infections with special emphasis on the role of CRISPR/Cas9 gene-based technology. The potential benefits of specific epigenetic modification in the c-c chemokine receptor 5 gene (CCR5) via various delivery methods are also highlighted. Jenkins, C, Micallef, ML, Padula, MP & Bogema, DR 2022, 'Characterisation of the Theileria orientalis Piroplasm Proteome across Three Common Genotypes', Pathogens, vol. 11, no. 10, pp. 1135-1135. Jha, SK, Imran, M, Paudel, KR, Mohammed, Y, Hansbro, P & Dua, K 2022, 'Treating Primary Lymphoma of The Brain in AIDS Patients Via Multifunctional Oral Nanoparticulate Systems', Nanomedicine, vol. 17, no. 7, pp. 425-429. Jiang, J, Huang, B, Daiyan, R, Subhash, B, Tsounis, C, Ma, Z, Han, C, Zhao, Y, Effendi, LH, Gallington, LC, Hart, JN, Scott, JA & Bedford, NM 2022, 'Defective Sn-Zn perovskites through bio-directed routes for modulating CO2RR', Nano Energy, vol. 101, pp. 107593-107593. Jiang, J, Wand, MP & Bhaskaran, A 2022, 'Usable and Precise Asymptotics for Generalized Linear Mixed Model Analysis and Design', Journal of the Royal Statistical Society Series B: Statistical Methodology, vol. 84, no. 1, pp. 55-82. Jiang, S, Suo, H, Zheng, X, Zhang, T, Lei, Y, Wang, Y, Lai, W & Wang, G 2022, 'Lightest Metal Leads to Big Change: Lithium‐Mediated Metal Oxides for Oxygen Evolution Reaction', Advanced Energy Materials, vol. 12, no. 33, pp. 2201934-2201934. Jiang, Z-K, Ren, R-J, Chang, Y-J, Zhou, W-H, Lu, Y-H, Wang, X-W, Wang, L, Wang, C-S, Solntsev, AS & Jin, X-M 2022, 'Direct Observation of Dynamically Localized Quantum Optical States', Physical Review Letters, vol. 129, no. 17, p. 173602. Quantum-correlated biphoton states play an important role in quantum communication and processing, especially considering the recent advances in integrated photonics. However, it remains a challenge to flexibly transport quantum states on a chip, when dealing with large-scale sophisticated photonic designs. The equivalence between certain aspects of quantum optics and solid-state physics makes it possible to utilize a range of powerful approaches in photonics, including topologically protected boundary states, graphene edge states, and dynamic localization. Optical dynamic localization allows efficient protection of classical signals in photonic systems by implementing an analogue of an external alternating electric field. Here, we report on the observation of dynamic localization for quantum-correlated biphotons, including both the generation and the propagation aspects. As a platform, we use sinusoidal waveguide arrays with cubic nonlinearity. We record biphoton coincidence count rates as evidence of robust generation of biphotons and demonstrate the dynamic localization features in both spatial and temporal space by analyzing the quantum correlation of biphotons at the output of the waveguide array. Experimental results demonstrate that various dynamic modulation parameters are effective in protecting quantum states without introducing complex topologies. Our Letter opens new avenues for studying complex physical processes using photonic chips and provides an alternative mechanism of protecting communication channels and nonclassical quantum sources in large-scale integrated quantum optics. Jing, W, Pilato, JL, Kay, C, Feng, S, Tuipulotu, DE, Mathur, A, Shen, C, Ngo, C, Zhao, A, Miosge, LA, Ali, SA, Gardiner, EE, Awad, MM, Lyras, D, Robertson, AAB, Kaakoush, NO & Man, SM 2022, 'Clostridium septicum α-toxin activates the NLRP3 inflammasome by engaging GPI-anchored proteins', Science Immunology, vol. 7, no. 71. Johansen, MD, Mahbub, RM, Idrees, S, Nguyen, DH, Miemczyk, S, Pathinayake, P, Nichol, K, Hansbro, NG, Gearing, LJ, Hertzog, PJ, Gallego-Ortega, D, Britton, WJ, Saunders, BM, Wark, PA, Faiz, A & Hansbro, PM 2022, 'Increased SARS-CoV-2 Infection, Protease, and Inflammatory Responses in Chronic Obstructive Pulmonary Disease Primary Bronchial Epithelial Cells Defined with Single-Cell RNA Sequencing', American Journal of Respiratory and Critical Care Medicine, vol. 206, no. 6, pp. 712-729. Rationale: Patients with chronic obstructive pulmonary disease (COPD) develop more severe coronavirus disease (COVID-19); however, it is unclear whether they are more susceptible to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and what mechanisms are responsible for severe disease. Objectives: To determine whether SARS-CoV-2 inoculated primary bronchial epithelial cells (pBECs) from patients with COPD support greater infection and elucidate the effects and mechanisms involved. Methods: We performed single-cell RNA sequencing analysis on differentiated pBECs from healthy subjects and patients with COPD 7 days after SARS-CoV-2 inoculation. We correlated changes with viral titers, proinflammatory responses, and IFN production. Measurements and Main Results: Single-cell RNA sequencing revealed that COPD pBECs had 24-fold greater infection than healthy cells, which was supported by plaque assays. Club/goblet and basal cells were the predominant populations infected and expressed mRNAs involved in viral replication. Proteases involved in SARS-CoV-2 entry/infection (TMPRSS2 and CTSB) were increased, and protease inhibitors (serpins) were downregulated more so in COPD. Inflammatory cytokines linked to COPD exacerbations and severe COVID-19 were increased, whereas IFN responses were blunted. Coexpression analysis revealed a prominent population of club/goblet cells with high type 1/2 IFN responses that were important drivers of immune responses to infection in both healthy and COPD pBECs. Therapeutic inhibition of proteases and inflammatory imbalances reduced viral titers and cytokine responses, particularly in COPD pBECs. Conclusions: COPD pBECs are more susceptible to SARS-CoV-2 infection because of increases in coreceptor expression and protease imbalances and have greater inflammatory responses. A prominent cluster of IFN-responsive club/goblet cells emerges during infection, which may be important drivers of immunity. Therapeutic i... John, AR, Singh, AK, Do, T-TN, Eidels, A, Nalivaiko, E, Gavgani, AM, Brown, S, Bennett, M, Lal, S, Simpson, AM, Gustin, SM, Double, K, Walker, FR, Kleitman, S, Morley, J & Lin, C-T 2022, 'Unraveling the Physiological Correlates of Mental Workload Variations in Tracking and Collision Prediction Tasks', IEEE Transactions on Neural Systems and Rehabilitation Engineering, vol. 30, no. 99, pp. 770-781. Modern work environments have extensive interactions with technology and greater cognitive complexity of the tasks, which results in human operators experiencing increased mental workload. Air traffic control operators routinely work in such complex environments, and we designed tracking and collision prediction tasks to emulate their elementary tasks. The physiological response to the workload variations in these tasks was elucidated to untangle the impact of workload variations experienced by operators. Electroencephalogram (EEG), eye activity, and heart rate variability (HRV) data were recorded from 24 participants performing tracking and collision prediction tasks with three levels of difficulty. Our findings indicate that variations in task load in both these tasks are sensitively reflected in EEG, eye activity and HRV data. Multiple regression results also show that operators' performance in both tasks can be predicted using the corresponding EEG, eye activity and HRV data. The results also demonstrate that the brain dynamics during each of these tasks can be estimated from the corresponding eye activity, HRV and performance data. Furthermore, the markedly distinct neurometrics of workload variations in the tracking and collision prediction tasks indicate that neurometrics can provide insights on the type of mental workload. These findings have applicability to the design of future mental workload adaptive systems that integrate neurometrics in deciding not just 'when' but also 'what' to adapt. Our study provides compelling evidence in the viability of developing intelligent closed-loop mental workload adaptive systems that ensure efficiency and safety in complex work environments. Johnson, AP, Ryan, CP & Wallman, JF 2022, 'Climatic and biotic influences on the distributions of Calliphora augur and Calliphora dubia (Diptera: Calliphoridae)', Austral Entomology, vol. 61, no. 3, pp. 370-377. Johnson, B, Zhuang, L, Rath, EM, Yuen, ML, Cheng, NC, Shi, H, Kao, S, Reid, G & Cheng, YY 2022, 'Exploring MicroRNA and Exosome Involvement in Malignant Pleural Mesothelioma Drug Response', Cancers, vol. 14, no. 19, pp. 4784-4784. Johnson, D, Clases, D, Fernández-Sánchez, ML, Eiro, N, González, LO, Vizoso, FJ, Doble, PA & Gonzalez de Vega, R 2022, 'Quantitative multiplexed analysis of MMP-11 and CD45 in metastatic breast cancer tissues by immunohistochemistry-assisted LA–ICP–MS', Metallomics, vol. 14, no. 8, p. mfac052. Johnson, M, Burns, B, Herdean, A, Angeloski, A, Ralph, P, Morris, T, Kindler, G, Wong, H, Kuzhiumparambil, U, Sedger, L & Larkum, A 2022, 'A Cyanobacteria Enriched Layer of Shark Bay Stromatolites Reveals a New Acaryochloris Strain Living in Near Infrared Light', Microorganisms, vol. 10, no. 5, pp. 1035-1035. Jolliffe, KKA & Gale, PA 2022, 'The supramolecular chemistry of anions', Organic & Biomolecular Chemistry, vol. 20, no. 4, pp. 713-714. Jones, NI, Harmer, CJ, Hamidian, M & Hall, RM 2022, 'Evolution of Acinetobacter baumannii plasmids carrying the oxa58 carbapenemase resistance gene via plasmid fusion, IS26-mediated events and dif module shuffling', Plasmid, vol. 121, pp. 102628-102628. Acinetobacter baumannii RepAci1-RepAci10 plasmids pA388 from a global clone 1 (GC1) isolate from Greece, and pACICU1 and variant pACICU1b from an Italian GC2 isolate were found to share a common ancestor. The ancestor formed via recombination between pdif sites in the widely-distributed RepAci1 plasmid pA1-1 and in a RepAci10 plasmid carrying the oxa58 carbapenem-resistance gene in a dif module. Each plasmid includes copies of IS26 and multiple dif modules surrounded by 28 bp pdif sites resembling the chromosomal dif site, including one carrying the oxa58 gene. Plasmid sequences were compared to identify factors driving their evolution and divergence. IS26-mediated events, recombination between pdif sites and homologous recombination have all contributed. A translocatable unit that includes oxa58, generated by an IS26-mediated adjacent deletion, had been re-inserted by IS26 adjacent to an IS26 in pACICU1b to create the oxa58 gene duplication previously found in pACICU1. The oxa58 duplication has been lost from pACICU1b and the Tn6020 variant carrying the aphA1 (kanamycin, neomycin resistance) gene in pA388 has been lost from pACICU1/1b via recombination between directly-oriented IS26 copies. Two dif modules located between directly-oriented pdif sites in pA388 have been lost from pACICU1/1b and the product of this and other deletion events as well as inversion of dif modules located between inversely-oriented pdif sites were detected experimentally in pA388 DNA by PCR. Also, the new junctions were detected in a minority of reads in pA388 long-read sequence data. Inversion and deletion were only detected when the spacers in the pdif sites were identical and equivalent events involving mismatched spacers were not detected. Ju, Z, Zhao, Q, Chao, D, Hou, Y, Pan, H, Sun, W, Yuan, Z, Li, H, Ma, T, Su, D & Jia, B 2022, 'Energetic Aqueous Batteries', Advanced Energy Materials, vol. 12, no. 27, pp. 2201074-2201074. Kam, JY, Hortle, E, Krogman, E, Warner, SE, Wright, K, Luo, K, Cheng, T, Manuneedhi Cholan, P, Kikuchi, K, Triccas, JA, Britton, WJ, Johansen, MD, Kremer, L & Oehlers, SH 2022, 'Rough and smooth variants of Mycobacterium abscessus are differentially controlled by host immunity during chronic infection of adult zebrafish', Nature Communications, vol. 13, no. 1, pp. 1-11. Karacan, I, Ben‐Nissan, B, Santos, J, Yiu, S, Bradbury, P, Valenzuela, SM & Chou, J 2022, 'In vitro testing and efficacy of poly‐lactic acid coating incorporating antibiotic loaded coralline bioceramic on Ti6Al4V implant against Staphylococcus aureus', Journal of Tissue Engineering and Regenerative Medicine, vol. 16, no. 12, pp. 1149-1162. Biofilm formation on an implant surface is most commonly caused by the human pathogenic bacteria Staphylococcus aureus, which can lead to implant related infections and failure. It is a major problem for both implantable orthopedic and maxillofacial devices. The current antibiotic treatments are typically delivered orally or in an injectable form. They are not highly effective in preventing or removing biofilms, and they increase the risk of antibiotic resistance of bacteria and have a dose-dependent negative biological effect on human cells. Our aim was to improve current treatments via a localized and controlled antibiotic delivery-based implant coating system to deliver the antibiotic, gentamicin (Gm). The coating contains coral skeleton derived hydroxyapatite powders (HAp) that act as antibiotic carrier particles and have a biodegradable poly-lactic acid (PLA) thin film matrix. The system is designed to prevent implant related infections while avoiding the deleterious effects of high concentration antibiotics in implants on local cells including primary human adipose derived stem cells (ADSCs). Testing undertaken in this study measured the rate of S. aureus biofilm formation and determined the growth rate and proliferation of ADSCs. After 24 h, S. aureus biofilm formation and the percentage of live cells found on the surfaces of all 5%-30% (w/w) PLA-Gm-(HAp-Gm) coated Ti6Al4V implants was lower than the control samples. Furthermore, Ti6Al4V implants coated with up to 10% (w/w) PLA-Gm-(HAp-Gm) did not have noticeable Gm related adverse effect on ADSCs, as assessed by morphological and surface attachment analyses. These results support the use and application of the antibacterial PLA-Gm-(HAp-Gm) thin film coating design for implants, as an antibiotic release control mechanism to prevent implant-related infections. Katona, K, Sklibosios Nikitopoulos, C & Schlögl, E 2022, 'A Hyperbolic Bid Stack Approach to Electricity Price Modelling', Risks, vol. 11, no. 8, pp. 147-147. Kaur, J, Gulati, M, Corrie, L, Awasthi, A, Jha, NK, Chellappan, DK, Gupta, G, MacLoughlin, R, Oliver, BG, Dua, K & Singh, SK 2022, 'Role of Nucleic Acid-Based Polymeric Micelles in Treating Lung Diseases', Nanomedicine, vol. 17, no. 25, pp. 1951-1960. Kaur, J, Gulati, M, Famta, P, Corrie, L, Awasthi, A, Saini, S, Khatik, GL, Bettada, VG, Madhunapantula, SV, Paudel, KR, Gupta, G, Chellappan, DK, Arshad, MF, Adams, J, Gowthamarajan, K, Dua, K, Hansbro, PM & Singh, SK 2022, 'Polymeric micelles loaded with glyburide and vanillic acid: I. Formulation development, in-vitro characterization and bioavailability studies', International Journal of Pharmaceutics, vol. 624, pp. 121987-121987. KC, BB, Khanal, P, Oli, LK, Dhital, SR, Pradhan, B, Pahari, DP & Paudel, KR 2022, 'Prevalence and Factors Associated with Tobacco Use among High School Students', Journal of Nepal Health Research Council, vol. 20, no. 02, pp. 310-315. Keen, B, Cawley, A, Reedy, B & Fu, S 2022, 'Metabolomics in clinical and forensic toxicology, sports anti‐doping and veterinary residues', Drug Testing and Analysis, vol. 14, no. 5, pp. 794-807. Kendig, MD, Hasebe, K, McCague, R, Lee, F, Leigh, S-J, Arnold, R & Morris, MJ 2022, 'Adolescent exposure to a solid high-fat, high-sugar ‘cafeteria’ diet leads to more pronounced changes in metabolic measures and gut microbiome composition than liquid sugar in female rats', Appetite, vol. 172, pp. 105973-105973. Khan, AZ, Malik, S, Mehmood, MA, Shahid, A, Shahzad, T, Zhao, X-Q, Bai, F-W & Liu, C-G 2022, 'Two-stage algal cultivation for the biotransformation of urban wastewater’s pollutants into multiple bioproducts in a circular bioeconomy paradigm', Energy Conversion and Management, vol. 273, pp. 116400-116400. Resource recovery and recycling of urban wastewater have become essential due to rapidly depleting water resources. Here, a newly isolated cyanobacterium Pseudoscillatoria coralii BERC01 was employed for the biotreatment of urban wastewater (UWW) via a two-stage cultivation system followed by biotransformation of the biomass into multiple bioproducts. During the stage-I, the cyanobacterial strain BERC01 removed 100 % suspended solids (9–27 g/L) from the UWW within 3–7 days via biosorption, and the resultant biomass was used as a soil amender which improved the phosphate availability, microbial carbon biomass, and nitrate-nitrogen of the soil by 2.65–5.86-fold, 2.27–3.65-fold, and 3.20–6.57-fold, respectively. During stage-II, re-culturing the BERC01 in the recycled water improved the productivities of carbohydrates and proteins by 10-fold and 3-fold, respectively, when compared to the control. Cultivation of BERC01 also improved the pH of UWW (9.47 ± 0.2 – 10.93 ± 0.16) to reduce the bacterial and/or fungal contamination. The two-stage cultivation of BERC01 in the UWW lowered the total nitrogen, total phosphorous, chemical oxygen demand, and biological oxygen demand of the UWW by 41.94 %, 95 %, 79 %, and 89.64 %, respectively, bringing the quality of treated water within the WHO's safety limits of agricultural purposes. Cascading processing of the stage-II biomass yielded food-grade pigments (phycocyanin = 148.95 ± 1.81 mg/g, allophycocyanin = 51.92 ± 0.51 mg/g), and 470–490 mg/g of lipids which contained compounds of pharmaceutical interest such as undecanoic acid, pentadecanoic acid, and eicosanoic acid. Finally, the pigment-free and de-oiled residual biomass (PDRB) was completely valorized to mycoprotein and α-amylase through fungal fermentation using 10–50 g/L PDRB as a sole source of nutrition. Resultantly, Aspergillus niger and Aspergillus oryzae produced 98.44 U/mL and 118.56 U/mL of α-amylase in 96 h of incubation, respectively, whereas the protein conten... Khan, K, Tareen, AK, Iqbal, M, Zhang, Y, Mahmood, A, Mahmood, N, Yin, J, Khatoon, R & Zhang, H 2022, 'Recent advance in MXenes: New horizons in electrocatalysis and environmental remediation technologies', Progress in Solid State Chemistry, vol. 68, pp. 100370-100370. Khursheed, R, Dua, K, Vishwas, S, Gulati, M, Jha, NK, Aldhafeeri, GM, Alanazi, FG, Goh, BH, Gupta, G, Paudel, KR, Hansbro, PM, Chellappan, DK & Singh, SK 2022, 'Biomedical applications of metallic nanoparticles in cancer: Current status and future perspectives', Biomedicine & Pharmacotherapy, vol. 150, pp. 112951-112951. Kianinia, M, Xu, Z-Q, Toth, M & Aharonovich, I 2022, 'Quantum emitters in 2D materials: Emitter engineering, photophysics, and integration in photonic nanostructures', Applied Physics Reviews, vol. 9, no. 1, pp. 1-18. Kim, E, Kim, Y-J, Ji, Z, Kang, JM, Wirianto, M, Paudel, KR, Smith, JA, Ono, K, Kim, J-A, Eckel-Mahan, K, Zhou, X, Lee, HK, Yoo, JY, Yoo, S-H & Chen, Z 2022, 'ROR activation by Nobiletin enhances antitumor efficacy via suppression of IκB/NF-κB signaling in triple-negative breast cancer', Cell Death & Disease, vol. 13, no. 4. Kindler, GS, Wong, HL, Larkum, AWD, Johnson, M, MacLeod, FI & Burns, BP 2022, 'Genome-resolved metagenomics provides insights into the functional complexity of microbial mats in Blue Holes, Shark Bay', FEMS Microbiology Ecology, vol. 98, no. 1, p. fiab158. King, K, Bramucci, AR, Labbate, M, Raina, J-B & Seymour, JR 2022, 'Heterogeneous Growth Enhancement of Vibrio cholerae in the Presence of Different Phytoplankton Species', Applied and Environmental Microbiology, vol. 88, no. 17, p. e0115822. Kirkby, K, Webster, J, Landa, BB, Olivares, C, Roser, S, Falconer, L, Gopurenko, D & Chapman, TA 2022, 'First report of the presence of Verticillium dahliae VCG6 in Australia', Australasian Plant Disease Notes, vol. 17, no. 1, p. 9. Klein, SG, Geraldi, NR, Anton, A, Schmidt‐Roach, S, Ziegler, M, Cziesielski, MJ, Martin, C, Rädecker, N, Frölicher, TL, Mumby, PJ, Pandolfi, JM, Suggett, DJ, Voolstra, CR, Aranda, M & Duarte, CM 2022, 'Projecting coral responses to intensifying marine heatwaves under ocean acidification', Global Change Biology, vol. 28, no. 5, pp. 1753-1765. Klingberg, J, Keen, B, Cawley, A, Pasin, D & Fu, S 2022, 'Developments in high-resolution mass spectrometric analyses of new psychoactive substances', Archives of Toxicology, vol. 96, no. 4, pp. 949-967. Knauer, J, Cuntz, M, Evans, JR, Niinemets, Ü, Tosens, T, Veromann‐Jürgenson, L, Werner, C & Zaehle, S 2022, 'Contrasting anatomical and biochemical controls on mesophyll conductance across plant functional types', New Phytologist, vol. 236, no. 2, pp. 357-368. Knott, GJ, Chong, YS, Passon, DM, Liang, X-H, Deplazes, E, Conte, MR, Marshall, AC, Lee, M, Fox, AH & Bond, CS 2022, 'Structural basis of dimerization and nucleic acid binding of human DBHS proteins NONO and PSPC1', Nucleic Acids Research, vol. 50, no. 1, pp. 522-535. Kondaveeti, S, Petri, DFS & Jeong, HE 2022, 'Efficiency of air-dried and freeze-dried alginate/xanthan beads in batch, recirculating and column adsorption processes', International Journal of Biological Macromolecules, vol. 204, pp. 345-355. Kong, J, Li, L, Liu, J, Marlton, FP, Jørgensen, MRV & Pramanick, A 2022, 'A Local Atomic Mechanism for Monoclinic-Tetragonal Phase Boundary Creation in Li-Doped Na0.5K0.5NbO3 Ferroelectric Solid Solution', Inorganic Chemistry, vol. 61, no. 10, pp. 4335-4349. Kononov, A, Memar, J & Zinder, Y 2022, 'On a borderline between the NP-hard and polynomial-time solvable cases of the flow shop with job-dependent storage requirements', Journal of Global Optimization, vol. 83, no. 3, pp. 445-456. Kottek, M & Yuen, ML 2022, 'Public health risks from asbestos cement roofing', American Journal of Industrial Medicine, vol. 65, no. 3, pp. 157-161. Krich, C, Mahecha, MD, Migliavacca, M, De Kauwe, MG, Griebel, A, Runge, J & Miralles, DG 2022, 'Decoupling between ecosystem photosynthesis and transpiration: a last resort against overheating', Environmental Research Letters, vol. 17, no. 4, pp. 044013-044013. Krix, DW & Murray, BR 2022, 'A Predictive Model of Leaf Flammability Using Leaf Traits and Radiant Heat Flux for Plants of Fire-Prone Dry Sclerophyll Forest', Forests, vol. 13, no. 2, pp. 152-152. Krix, DW, Murray, ML & Murray, BR 2022, 'Increasing radiant heat flux affects leaf flammability patterns in plant species of eastern Australian fire‐prone woodlands', Plant Biology, vol. 24, no. 2, pp. 302-312. Kumar, R, Kumar, R, Sharma, N, Khurana, N, Singh, SK, Satija, S, Mehta, M & Vyas, M 2022, 'Pharmacological evaluation of bromelain in mouse model of Alzheimer’s disease', NeuroToxicology, vol. 90, pp. 19-34. Kumari, N, Srivastava, A & Kumar, S 2022, 'Hydrological Analysis Using Observed and Satellite-Based Estimates: Case Study of a Lake Catchment in Raipur, India', Journal of the Indian Society of Remote Sensing, vol. 50, no. 1, pp. 115-128. Rainfall plays an essential role in different water management sectors ranging from industries, farming, livestock, and domestic utilization both in rural and urban areas. The surface water bodies like rivers, lakes, ponds, and reservoirs hold a huge proportion of the rainfall. However, due to spatio-temporal variability of rainfall and limited availability of meteorological stations, accurate estimation of the hydrological components such as surface runoff, evaporation, and baseflow is a challenging task. In this study, we have used hydrological information, Soil Conservation Service Curve Number method to develop an empirical relationship between rainfall and runoff in the Telibandha Lake Catchment (TLC), situated in Raipur district of Chhattisgarh, central India. Further, we have used Landsat derived remote sensing product, Normalized Difference Water Index (NDWI) to understand its temporal variation of water spread in the TLC over the fifteen years (2001–2015). The water spread areas are assessed by using the mean monthly NDWI data set and analyzing its seasonal and annual patterns. It is found that Telibandha Lake has a maximum depth of 2.9 m and its surface area is 0.12 km2. Apart from that, the annual runoff is around 232.28 mm, which accounts for almost 22% of the estimated rainfall. The monthly runoff coefficient varies from 0 to 0.25 in TLC. Both the temporal and spatial NDWI plots show that July–September months have high NDWI values in the TLC. The seasonal NDWI showed a good relationship with mean monthly rainfall data and depicts r2 = 0.78. The findings from this study helps in determining the temporal changes of water spread within the TLC and supports in understanding the lake characteristics. Kuzhiumparambil, U, Labeeuw, L, Commault, A, Vu, HP, Nguyen, LN, Ralph, PJ & Nghiem, LD 2022, 'Effects of harvesting on morphological and biochemical characteristics of microalgal biomass harvested by polyacrylamide addition, pH-induced flocculation, and centrifugation', Bioresource Technology, vol. 359, pp. 127433-127433. The effects of microalgae harvesting methods on microalgal biomass quality were evaluated using three species namely the freshwater green alga Chlorella vulgaris, marine red alga Porphyridium purpureum and marine diatom Phaeodactylum tricornutum. Harvesting efficiencies of polyacrylamide addition, alkaline addition, and centrifugation ranged from 85 to 95, 59-92 and 100%, respectively, across these species. Morphology of the harvested cells (i.e. compromised cell walls) was significantly impacted by alkaline pH-induced flocculation for all three species. Over 50% of C. vulgaris cells were compromised with alkaline pH compared to < 10% with polyacrylamide and centrifugation. The metabolic profiles varied depending on harvesting methods. Species-specific decrease of certain metabolites was observed. These results suggest that the method of harvest can alter the metabolic profile of the biomass amongst the three harvesting methods, polyacrylamide addition showed higher harvesting efficiency with less compromised cells and higher retention of industry important biochemicals. Kyu, HH, Vongpradith, A, Sirota, SB, Novotney, A, Troeger, CE, Doxey, MC, Bender, RG, Ledesma, JR, Biehl, MH, Albertson, SB, Frostad, JJ, Burkart, K, Bennitt, FB, Zhao, JT, Gardner, WM, Hagins, H, Bryazka, D, Dominguez, R-MV, Abate, SM, Abdelmasseh, M, Abdoli, A, Abdoli, G, Abedi, A, Abedi, V, Abegaz, TM, Abidi, H, Aboagye, RG, Abolhassani, H, Abtew, YD, Abubaker Ali, H, Abu-Gharbieh, E, Abu-Zaid, A, Adamu, K, Addo, IY, Adegboye, OA, Adnan, M, Adnani, QES, Afzal, MS, Afzal, S, Ahinkorah, BO, Ahmad, A, Ahmad, AR, Ahmad, S, Ahmadi, A, Ahmadi, S, Ahmed, H, Ahmed, JQ, Ahmed Rashid, T, Akbarzadeh-Khiavi, M, Al Hamad, H, Albano, L, Aldeyab, MA, Alemu, BM, Alene, KA, Algammal, AM, Alhalaiqa, FAN, Alhassan, RK, Ali, BA, Ali, L, Ali, MM, Ali, SS, Alimohamadi, Y, Alipour, V, Al-Jumaily, A, Aljunid, SM, Almustanyir, S, Al-Raddadi, RM, Al-Rifai, RHH, AlRyalat, SAS, Alvis-Guzman, N, Alvis-Zakzuk, NJ, Ameyaw, EK, Aminian Dehkordi, JJ, Amuasi, JH, Amugsi, DA, Anbesu, EW, Ansar, A, Anyasodor, AE, Arabloo, J, Areda, D, Argaw, AM, Argaw, ZG, Arulappan, J, Aruleba, RT, Asemahagn, MA, Athari, SS, Atlaw, D, Attia, EF, Attia, S, Aujayeb, A, Awoke, T, Ayana, TM, Ayanore, MA, Azadnajafabad, S, Azangou-Khyavy, M, Azari, S, Azari Jafari, A, Badar, M, Badiye, AD, Baghcheghi, N, Bagherieh, S, Baig, AA, Banach, M, Banerjee, I, Bardhan, M, Barone-Adesi, F, Barqawi, HJ, Barrow, A, Bashiri, A, Bassat, Q, Batiha, A-MM, Belachew, AB, Belete, MA, Belgaumi, UI, Bhagavathula, AS, Bhardwaj, N, Bhardwaj, P, Bhatt, P, Bhojaraja, VS, Bhutta, ZA, Bhuyan, SS, Bijani, A, Bitaraf, S, Bodicha, BBA, Briko, NI, Buonsenso, D, Butt, MH, Cai, J, Camargos, P, Cámera, LA, Chakraborty, PA, Chanie, MG, Charan, J, Chattu, VK, Ching, PR, Choi, S, Chong, YY, Choudhari, SG, Chowdhury, EK, Christopher, DJ, Chu, D-T, Cobb, NL, Cohen, AJ, Cruz-Martins, N, Dadras, O, Dagnaw, FT, Dai, X, Dandona, L, Dandona, R, Dao, ATM, Debela, SA, Demisse, B, Demisse, FW, Demissie, S, Dereje, D, Desai, HD, Desta, AA, Desye, B, Dhingra, S, Diao, N, Diaz, D, Digesa, LE, Doan, LP, Dodangeh, M, Dongarwar, D, Dorostkar, F, dos Santos, WM, Dsouza, HL, Dubljanin, E, Durojaiye, OC, Edinur, HA, Ehsani-Chimeh, E, Eini, E, Ekholuenetale, M, Ekundayo, TC, El Desouky, ED, El Sayed, I, El Sayed Zaki, M, Elhadi, M, Elkhapery, AMR, Emami, A, Engelbert Bain, L, Erkhembayar, R, Etaee, F, Ezati Asar, M & et al. 2022, 'Age–sex differences in the global burden of lower respiratory infections and risk factors, 1990–2019: results from the Global Burden of Disease Study 2019', The Lancet Infectious Diseases, vol. 22, no. 11, pp. 1626-1647. BACKGROUND: The global burden of lower respiratory infections (LRIs) and corresponding risk factors in children older than 5 years and adults has not been studied as comprehensively as it has been in children younger than 5 years. We assessed the burden and trends of LRIs and risk factors across all age groups by sex, for 204 countries and territories. METHODS: In this analysis of data for the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019, we used clinician-diagnosed pneumonia or bronchiolitis as our case definition for LRIs. We included International Classification of Diseases 9th edition codes 079.6, 466-469, 470.0, 480-482.8, 483.0-483.9, 484.1-484.2, 484.6-484.7, and 487-489 and International Classification of Diseases 10th edition codes A48.1, A70, B97.4-B97.6, J09-J15.8, J16-J16.9, J20-J21.9, J91.0, P23.0-P23.4, and U04-U04.9. We used the Cause of Death Ensemble modelling strategy to analyse 23 109 site-years of vital registration data, 825 site-years of sample vital registration data, 1766 site-years of verbal autopsy data, and 681 site-years of mortality surveillance data. We used DisMod-MR 2.1, a Bayesian meta-regression tool, to analyse age-sex-specific incidence and prevalence data identified via systematic reviews of the literature, population-based survey data, and claims and inpatient data. Additionally, we estimated age-sex-specific LRI mortality that is attributable to the independent effects of 14 risk factors. FINDINGS: Globally, in 2019, we estimated that there were 257 million (95% uncertainty interval [UI] 240-275) LRI incident episodes in males and 232 million (217-248) in females. In the same year, LRIs accounted for 1·30 million (95% UI 1·18-1·42) male deaths and 1·20 million (1·07-1·33) female deaths. Age-standardised incidence and mortality rates were 1·17 times (95% UI 1·16-1·18) and 1·31 times (95% UI 1·23-1·41) greater in males than in females in 2019. Between 1990 and 2019, LRI incidence and mortali... Lagune, M, Le Moigne, V, Johansen, MD, Vásquez Sotomayor, F, Daher, W, Petit, C, Cosentino, G, Paulowski, L, Gutsmann, T, Wilmanns, M, Maurer, FP, Herrmann, J-L, Girard-Misguich, F & Kremer, L 2022, 'The ESX-4 substrates, EsxU and EsxT, modulate Mycobacterium abscessus fitness', PLOS Pathogens, vol. 18, no. 8, pp. e1010771-e1010771. Laila, AZ, Fronzi, M, Kumegai, S, Sugiyama, K, Furui, R & Yamamoto, A 2022, 'High-Pressure Synthesis of High-Entropy Metal Disulfides with Pyrite-Type Structure', Journal of the Physical Society of Japan, vol. 91, no. 8. LaJeunesse, TC, Wiedenmann, J, Casado-Amezúa, P, D’Ambra, I, Turnham, KE, Nitschke, MR, Oakley, CA, Goffredo, S, Spano, CA, Cubillos, VM, Davy, SK & Suggett, DJ 2022, 'Revival of Philozoon Geddes for host-specialized dinoflagellates, ‘zooxanthellae’, in animals from coastal temperate zones of northern and southern hemispheres', European Journal of Phycology, vol. 57, no. 2, pp. 166-180. Lam, T, Barratt, MJ, Bartlett, M, Latimer, J, Jauncey, M, Hiley, S, Clark, N, Gerostamoulos, D, Glowacki, L, Roux, C, Morelato, M & Nielsen, S 2022, 'Infrequent detection of unintentional fentanyl use via urinalysis among people who regularly inject opioids in Sydney and Melbourne, Australia', Addiction, vol. 117, no. 8, pp. 2331-2337. Lao, JC, Bui, CB, Pang, MA, Cho, SX, Rudloff, I, Elgass, K, Schröder, J, Maksimenko, A, Mangan, NE, Starkey, MR, Skuza, EM, Sun, YBY, Beker, F, Collins, CL, Kamlin, OF, König, K, Malhotra, A, Tan, K, Theda, C, Young, MJ, McLean, CA, Wilson, NJ, Sehgal, A, Hansbro, PM, Pearson, JT, Polo, JM, Veldman, A, Berger, PJ, Nold-Petry, CA & Nold, MF 2022, 'Type 2 immune polarization is associated with cardiopulmonary disease in preterm infants', Science Translational Medicine, vol. 14, no. 639, p. eaaz8454. Lao, W, Zhao, Y, Tan, Y, Johnson, M, Li, Y, Xiao, L, Cheng, J, Lin, Y & Qu, X 2022, 'Regulatory Effects and Mechanism of Action of Green Tea Polyphenols on Osteogenesis and Adipogenesis in Human Adipose Tissue-Derived Stem Cells', Current Issues in Molecular Biology, vol. 44, no. 12, pp. 6046-6058. Larkin, BP, Nguyen, LT, Hou, M, Glastras, SJ, Chen, H, Faiz, A, Chen, J, Wang, R, Pollock, CA & Saad, S 2022, 'Low‐dose hydralazine reduces albuminuria and glomerulosclerosis in a mouse model of obesity‐related chronic kidney disease', Diabetes, Obesity and Metabolism, vol. 24, no. 10, pp. 1939-1949. Larsson, ME, Bramucci, AR, Collins, S, Hallegraeff, G, Kahlke, T, Raina, J-B, Seymour, JR & Doblin, MA 2022, 'Mucospheres produced by a mixotrophic protist impact ocean carbon cycling', Nature Communications, vol. 13, no. 1, p. 1301. Law, AMK, Chen, J, Colino‐Sanguino, Y, Fuente, LRDL, Fang, G, Grimes, SM, Lu, H, Huang, RJ, Boyle, ST, Venhuizen, J, Castillo, L, Tavakoli, J, Skhinas, JN, Millar, EKA, Beretov, J, Rossello, FJ, Tipper, JL, Ormandy, CJ, Samuel, MS, Cox, TR, Martelotto, L, Jin, D, Valdes‐Mora, F, Ji, HP & Gallego‐Ortega, D 2022, 'ALTEN: A High‐Fidelity Primary Tissue‐Engineering Platform to Assess Cellular Responses Ex Vivo', Advanced Science, vol. 9, no. 21, pp. e2103332-2103332. Lazenby, JJ, Li, ES & Whitchurch, CB 2022, 'Cell wall deficiency – an alternate bacterial lifestyle?', Microbiology, vol. 168, no. 8. Le Reun, N, Bramucci, A, O’Brien, J, Ostrowski, M, Brown, MV, Van de Kamp, J, Bodrossy, L, Raina, J-B, Ajani, P & Seymour, J 2022, 'Diatom Biogeography, Temporal Dynamics, and Links to Bacterioplankton across Seven Oceanographic Time-Series Sites Spanning the Australian Continent', Microorganisms, vol. 10, no. 2, pp. 338-338. Lee, HW, Lee, MS, Kim, T-H, Alraek, T, Zaslawski, C, Kim, JW & Moon, DG 2022, 'Ginseng for Erectile Dysfunction: A Cochrane Systematic Review', The World Journal of Men's Health, vol. 40, no. 2, pp. 264-264. Lee, PLT, Kanodarwala, FK, Lennard, C, Spindler, X, Spikmans, V, Roux, C & Moret, S 2022, 'Latent fingermark detection using functionalised silicon oxide nanoparticles: Investigation into novel application procedures', Forensic Science International, vol. 335, pp. 111275-111275. Investigations into the application of carboxyl-functionalised silicon oxide nanoparticles doped with a ruthenium complex (RuBpy-doped CES-SiO2 NPs) for latent fingermark development on non-porous surfaces were reported in previous studies. These studies suggested that an optimised NP-based method demonstrated advantages in fingermark selectivity and sensitivity. To continue the series of research into using RuBpy-doped CES-SiO2 NPs for fingermark detection, the versatility and overall practicality of the optimised SiO2 NP-based reagent for latent fingermark detection and enhancement was evaluated. When the optimised NP-based method was used in a repeated fashion (application of multiple NP treatment cycles), it was found that the overall fingermark detection quality increased across the evaluated fingermarks without a high risk of overdevelopment. The possibility of incorporating the optimised NP-based reagent for potential operational use (e.g., at crime scenes) was successfully demonstrated via spray application on three test surfaces (aluminium foil, transparent polypropylene film and green polyethylene film). It was also shown that further enhancement of 'spray-detected' fingermarks was achievable via subsequent treatment using the NP-based reagent in a colloidal dispersion bath. Additionally, the compatibility of the optimised NP-based method with two-step cyanoacrylate fuming for latent fingermark detection was evaluated. It was concluded that the two techniques are not compatible for application in a fingermark detection sequence. While encouraging results were demonstrated in this study, further optimisation and comparison will be required before the multiple-treatment and spray-treatment approaches can be considered for operational implementation. Lee, S-H, Kang, M, Jang, H, Kondaveeti, S, Sun, K, Kim, S, Park, H-H & Jeong, HE 2022, 'Bifunctional Amphiphilic Nanospikes with Antifogging and Antibiofouling Properties', ACS Applied Materials & Interfaces, vol. 14, no. 34, pp. 39478-39488. Leggat, W, Heron, SF, Fordyce, A, Suggett, DJ & Ainsworth, TD 2022, 'Experiment Degree Heating Week (eDHW) as a novel metric to reconcile and validate past and future global coral bleaching studies', Journal of Environmental Management, vol. 301, pp. 113919-113919. Coral bleaching has increasingly impacted reefs worldwide over the past four decades. Despite almost 40 years of research into the mechanistic, physiological, ecological, biophysical and climatic drivers of coral bleaching, metrics to allow comparison between ecological observations and experimental simulations still do not exist. Here we describe a novel metric - experimental Degree Heating Week (eDHW) - with which to standardise the persistently variable thermal conditions employed across experimental studies of coral bleaching by modify the widely used Degree Heating Week (DHW) metric used in ecological studies to standardise cumulative heat loading. Lei, Y, Sui, Y, Ding, S & Zhang, Q 2022, 'Taming transitive redundancy for context-free language reachability', Proceedings of the ACM on Programming Languages, vol. 6, no. OOPSLA2, pp. 1556-1582. Lei, Y, Wu, C, Lu, X, Hua, W, Li, S, Liang, Y, Liu, H, Lai, W, Gu, Q, Cai, X, Wang, N, Wang, Y, Chou, S, Liu, H, Wang, G & Dou, S 2022, 'Streamline Sulfur Redox Reactions to Achieve Efficient Room‐Temperature Sodium–Sulfur Batteries', Angewandte Chemie, vol. 134, no. 16. Lei, Y, Wu, C, Lu, X, Hua, W, Li, S, Liang, Y, Liu, H, Lai, W, Gu, Q, Cai, X, Wang, N, Wang, Y, Chou, S, Liu, H, Wang, G & Dou, S 2022, 'Streamline Sulfur Redox Reactions to Achieve Efficient Room‐Temperature Sodium–Sulfur Batteries', Angewandte Chemie International Edition, vol. 61, no. 16, p. e202200384. Leigh, A 2022, 'Using leaf shape to determine leaf size could be a game-changer. A commentary on: ‘Leaf size estimation based on leaf length, width and shape’', Annals of Botany, vol. 129, no. 2, pp. i-ii. Leng, S, Huete, A, Cleverly, J, Gao, S, Yu, Q, Meng, X, Qi, J, Zhang, R & Wang, Q 2022, 'Assessing the Impact of Extreme Droughts on Dryland Vegetation by Multi-Satellite Solar-Induced Chlorophyll Fluorescence', Remote Sensing, vol. 14, no. 7, pp. 1581-1581. Leng, S, Huete, A, Cleverly, J, Lu, X, Ma, X, Gao, S & Yu, Q 2022, 'Response of dryland vegetation under extreme wet events with satellite measures of greenness and fluorescence', Science of The Total Environment, vol. 842, pp. 156860-156860. Extreme wet events in central Australia triggered large vegetation responses that contributed greatly to large global land carbon sink anomalies. There remain significant uncertainties on the extent to which these events over dryland vegetation can be monitored and assessed with satellite data. In this study, we investigated the vegetation responses of the major Australian semiarid biomes to two extreme wet events utilizing multi-satellite observations of (1) solar-induced chlorophyll fluorescence (SIF), as a proxy for photosynthetic activity and (2) the enhanced vegetation index (EVI), as a measure of canopy chlorophyll or greenness. We related these satellite observations with gross primary productivity (GPP) estimated from eddy covariance tower sites, as a performance benchmark. The C3-dominated Mulga woodland was the most responsive biome to both wet pulses and exhibited the highest sensitivity to soil moisture. The C4-dominated Hummock grassland was more responsive to the 2011 'big wet' event, relative to the later 2016-2017 wet pulse. EVI swiftly responded to the extreme wet events and showed markedly amplified seasonal amplitude, however, there was a time lag as compared with SIF during the post-wet period, presumably due to the relatively slower chlorophyll degradation in contrast with declines in photosynthetic activity. Despite a robust linear SIF-GPP relationship (r2 ranging from 0.59 to 0.85), the spatially coarse SIF derived from the Global Ozone Monitoring Experiment-2 (GOME-2) yielded high retrieval noise over the xeric biomes, hindering its capacity to capture thoroughly the dryland vegetation dynamics in central Australia. Our study highlights that synchronous satellite observations of greenness and fluorescence can potentially offer an improved understanding of dryland vegetation dynamics and can advance our ability to detect ecosystem alterations under future changing climates. Leng, S, Huete, A, Cleverly, J, Yu, Q, Zhang, R & Wang, Q 2022, 'Spatiotemporal Variations of Dryland Vegetation Phenology Revealed by Satellite-Observed Fluorescence and Greenness across the North Australian Tropical Transect', Remote Sensing, vol. 14, no. 13, pp. 2985-2985. Leong, W, Poh, WH, Williams, J, Lutz, C, Hoque, MM, Poh, YH, Yee, BYK, Chua, C, Givskov, M, Sanderson-Smith, M, Rice, SA & McDougald, D 2022, 'Adaptation to an Amoeba Host Leads to Pseudomonas aeruginosa Isolates with Attenuated Virulence', Applied and Environmental Microbiology, vol. 88, no. 5, p. aem0232221. Lewis, BM, Suggett, DS, Prentis, PJ & Nothdurft, LD 2022, 'Cellular adaptations leading to coral fragment attachment on artificial substrates in Acropora millepora (Am-CAM)', Scientific Reports, vol. 12, no. 1, p. 18431. Lewis, RE, Davy, SK, Gardner, SG, Rongo, T, Suggett, DJ & Nitschke, MR 2022, 'Colony self-shading facilitates Symbiodiniaceae cohabitation in a South Pacific coral community', Coral Reefs, vol. 41, no. 5, pp. 1433-1447. Li, F, Guo, X, Xiang, D, Pitt, ME, Bainomugisa, A & Coin, LJM 2022, 'Computational analysis and prediction of PE_PGRS proteins using machine learning', Computational and Structural Biotechnology Journal, vol. 20, pp. 662-674. Li, G, Hao, Y, Yang, T, Wu, J, Xu, F, Li, L, Wang, B, Li, M, Zhao, N, Wang, N, Liu, C, Huang, Z, Zhou, Y & Zhao, Y 2022, 'Air pollutant emissions from sludge-bituminous briquettes as a potential household energy source', Case Studies in Thermal Engineering, vol. 37, pp. 102251-102251. Li, J, Ahmed, W, Metcalfe, S, Smith, WJM, Tscharke, B, Lynch, P, Sherman, P, Vo, PHN, Kaserzon, SL, Simpson, SL, McCarthy, DT, Thomas, KV, Mueller, JF & Thai, P 2022, 'Monitoring of SARS-CoV-2 in sewersheds with low COVID-19 cases using a passive sampling technique', Water Research, vol. 218, pp. 118481-118481. Monitoring SARS-CoV-2 RNA in sewer systems, upstream of a wastewater treatment plant, is an effective approach for understanding potential COVID-19 transmission in communities with higher spatial resolutions. Passive sampling devices provide a practical solution for frequent sampling within sewer networks where the use of autosamplers is not feasible. Currently, the design of upstream sampling is impeded by limited understanding of the fate of SARS-CoV-2 RNA in sewers and the sensitivity of passive samplers for the number of infected individuals in a catchment. In this study, passive samplers containing electronegative membranes were applied for at least 24-h continuous sampling in sewer systems. When monitoring SARS-CoV-2 along a trunk sewer pipe, we found RNA signals decreased proportionally to increasing dilutions, with non-detects occurring at the end of pipe. The passive sampling membranes were able to detect SARS-CoV-2 shed by >2 COVID-19 infection cases in 10,000 people. Moreover, upstream monitoring in multiple sewersheds using passive samplers identified the emergence of SARS-CoV-2 in wastewater one week ahead of clinical reporting and reflected the spatiotemporal spread of a COVID-19 cluster within a city. This study provides important information to guide the development of wastewater surveillance strategies at catchment and subcatchment levels using different sampling techniques. Li, J, Luu, LDW, Wang, X, Cui, X, Huang, X, Fu, J, Zhu, X, Li, Z, Wang, Y & Tai, J 2022, 'Metabolomic analysis reveals potential biomarkers and the underlying pathogenesis involved in Mycoplasma pneumoniae pneumonia', Emerging Microbes & Infections, vol. 11, no. 1, pp. 593-605. Although previous studies have reported the use of metabolomics for infectious diseases, little is known about the potential function of plasma metabolites in children infected with Mycoplasma pneumoniae (MP). Here, a combination of liquid chromatography-quadrupole time-of-flight mass spectrometry and random forest-based classification model was used to provide a broader range of applications in MP diagnosis. In the training cohort, plasma from 63 MP pneumonia children (MPPs), 37 healthy controls (HC) and 29 infectious disease controls (IDC) was collected. After multivariate analyses, 357 metabolites were identified to be differentially expressed among MPP, HC and IDC groups, and 3 metabolites (568.5661, 459.3493 and 411.3208) had high diagnostic values. In an independent cohort with 57 blinded subjects, samples were successfully classified into different groups, demonstrating the reliability of these biomarkers for distinguishing MPPs from controls. A metabolomic signature analysis identified major classes of glycerophospholipids, sphingolipids and fatty acyls were increased in MPPs. These markedly altered metabolites are mainly involved in glycerophospholipid and sphingolipid metabolism. As the ubiquitous building blocks of eukaryotic cell membranes, dysregulated lipid metabolism indicates damage of the cellular membrane and the activation of immunity in MPPs. Moreover, lipid metabolites, differentially expressed between severe and mild MPPs, were correlated with the markers of extrapulmonary complications, suggesting that they may be involved in MPP disease severity. These findings may offer new insights into biomarker selection and the pathogenesis of MPP in children. Li, J, Song, J, Luo, L, Zhang, H, Feng, J, Zhao, X, Guo, X, Dong, H, Chen, S, Liu, H, Shao, G, Anthopoulos, TD, Su, Y, Wang, F & Wang, G 2022, 'Synergy of MXene with Se Infiltrated Porous N‐Doped Carbon Nanofibers as Janus Electrodes for High‐Performance Sodium/Lithium–Selenium Batteries', Advanced Energy Materials, vol. 12, no. 32, pp. 2200894-2200894. Li, L, Mac Aogáin, M, Xu, T, Jaggi, TK, Chan, LLY, Qu, J, Wei, L, Liao, S, Cheng, HS, Keir, HR, Dicker, AJ, Tan, KS, De Yun, W, Koh, MS, Ong, TH, Lim, AYH, Abisheganaden, JA, Low, TB, Hassan, TM, Long, X, Wark, PAB, Oliver, B, Drautz-Moses, DI, Schuster, SC, Tan, NS, Fang, M, Chalmers, JD & Chotirmall, SH 2022, 'Neisseria species as pathobionts in bronchiectasis', Cell Host & Microbe, vol. 30, no. 9, pp. 1311-1327.e8. Neisseria species are frequently identified in the bronchiectasis microbiome, but they are regarded as respiratory commensals. Using a combination of human cohorts, next-generation sequencing, systems biology, and animal models, we show that bronchiectasis bacteriomes defined by the presence of Neisseria spp. associate with poor clinical outcomes, including exacerbations. Neisseria subflava cultivated from bronchiectasis patients promotes the loss of epithelial integrity and inflammation in primary epithelial cells. In vivo animal models of Neisseria subflava infection and metabolipidome analysis highlight immunoinflammatory functional gene clusters and provide evidence for pulmonary inflammation. The murine metabolipidomic data were validated with human Neisseria-dominant bronchiectasis samples and compared with disease in which Pseudomonas-, an established bronchiectasis pathogen, is dominant. Metagenomic surveillance of Neisseria across various respiratory disorders reveals broader importance, and the assessment of the home environment in bronchiectasis implies potential environmental sources of exposure. Thus, we identify Neisseria species as pathobionts in bronchiectasis, allowing for improved risk stratification in this high-risk group. Li, M, Kobayashi, R, Amos, RD, Ford, MJ & Reimers, JR 2022, 'Density functionals with asymptotic-potential corrections are required for the simulation of spectroscopic properties of materials', Chemical Science, vol. 13, no. 5, pp. 1492-1503. Li, M, Wen Ma, Z, Jun Deng, S, Oliver, BG, Wang, T, Ping Zhang, H, Wang, L, McDonald, VM, Wang, J, Liu, D, Gibson, PG, Ming Luo, F, Min Li, W, Jing Wan, H & Wang, G 2022, 'Development and validation of a noninvasive prediction model for identifying eosinophilic asthma', Respiratory Medicine, vol. 201, pp. 106935-106935. BACKGROUND: Identification of eosinophilic asthma (EA) using sputum analysis is important for disease monitoring and individualized treatment. But it is laborious and technically demanding. We aimed to develop and validate an effective model to predict EA with multidimensional assessment (MDA). METHODS: The asthma patients who underwent a successful sputum induction cytological analysis were consecutively recruited from March 2014 to January 2021. The variables assessed by MDA were screened by least absolute shrinkage and selection operator (LASSO) and logistic regression to develop a nomogram and an online web calculator. Validation was performed internally by a bootstrap sampling method and externally in the validation cohort. Diagnostic accuracy of the model in different asthma subgroups were also investigated. RESULTS: In total of 304 patients in the training cohort and 95 patients in the validation cohort were enrolled. Five variables were identified in the EA prediction model: gender, nasal polyp, blood eosinophils, blood basophils and FeNO. The C-index of the model was 0.86 (95% CI: 0.81-0.90) in the training cohort and 0.84 (95% CI: 0.72-0.89) in the validation cohort. The calibration curve showed good agreement between the prediction and actual observation. The decision curve analysis (DCA) also demonstrated that the EA prediction model was clinically beneficial. An online publicly available web calculator was constructed (https://asthmaresearcherlimin.shinyapps.io/DynNomapp/). CONCLUSION: We developed and validated a multivariable model based on MDA to help the diagnosis of EA, which has good diagnostic performance and clinical practicability. This practical tool may be a useful alternative for predicting EA in the clinic. Li, M-Y, Qin, Y-Q, Tian, Y-G, Li, K-C, Oliver, BG, Liu, X-F, Zhao, P & Li, J-S 2022, 'Effective-component compatibility of Bufei Yishen formula III ameliorated COPD by improving airway epithelial cell senescence by promoting mitophagy via the NRF2/PINK1 pathway', BMC Pulmonary Medicine, vol. 22, no. 1, p. 434. Li, T, Geier, M, Ingham, J & D Scammell, H 2022, 'Higher-order topological superconductivity from repulsive interactions in kagome and honeycomb systems', 2D Materials, vol. 9, no. 1, pp. 015031-015031. Li, T, Ingham, J & Scammell, HD 2022, 'Nested Fermi surfaces and correlated electronic phases in hole-doped semiconductor quantum wells', Physical Review B, vol. 105, no. 11, p. 115302. We demonstrate the existence of novel interaction effects in hole-doped semiconductor quantum wells which are connected to dramatic changes in the Fermi surface geometry occurring upon variation of the doping. We present band structure calculations showing that quantum wells formed in p-type cubic semiconductors develop perfectly nested Fermi surfaces at a critical hole density p~1/d2 set by the width d of the quantum well. Nesting gives rise to competing superconducting and charge or spin density wave order, which we analyze using the perturbative renormalization group method. The correlated phases may be created or destroyed by tuning the hole density towards or away from the critical density. Our results establish p-type semiconductor quantum wells as a platform for novel correlated phases, which may be precisely controlled using electrostatic gating and external magnetic fields. Li, Y, Ji, X, Chang, L, Tang, J, Hua, M, Liu, J, O'Neill, C, Huang, X & Jin, X 2022, 'Click-iT® Plus OPP Alexa Fluor® Protein Synthesis Assay in Embryonic Cells', BIO-PROTOCOL, vol. 12, no. 11. Liang, M, Li, L, Cui, X, Qi, S, Wang, L, Dong, H, Chen, X, Wang, Y, Chen, S & Wang, G 2022, 'Ru‐ and Cl‐Codoped Li3V2(PO4)3 with Enhanced Performance for Lithium‐Ion Batteries in a Wide Temperature Range', Small, vol. 18, no. 29, pp. e2202151-2202151. Liao, J, Yang, L, Wu, S, Yang, Z, Zhou, J, Jin, D & Guan, M 2022, 'NIR-II emissive properties of 808 nm-excited lanthanide-doped nanoparticles for multiplexed in vivo imaging', Journal of Luminescence, vol. 242, pp. 118597-118597. The second near-infrared window (1000–1700 nm, NIR-II) emissive lanthanide-doped nanoparticles excited by 808 nm laser are ideal for in vivo bioimaging due to their non-heating excitation. The study of 808 nm excited lanthanide-doped nanoparticles not only provides high-quality NIR-II imaging but also can promote in vivo multiplexed bioimaging under single excitation. Herein, we prepared three sets of typical 808 nm excited lanthanide-doped nanoparticles (NaYF4: Nd3+@NaYF4, NaErF4@NaYF4, and NaYbF4: Er3+/Ce3+@NaYbF4@NaYF4: Yb3+/Nd3+) and then systematically compared their optical properties in the NIR-II window. Furthermore, we prepared water-soluble and biocompatible nanoprobes and achieved multiplexed NIR-II in vivo imaging in mice under single 808 nm excitation. These results highlight the potential of 808 nm excited lanthanide probes for physiological studies and biomedical applications. Liepa, R, Mann, R, Osman, M, Hamze, M, Gunawan, C & Hamidian, M 2022, 'Cl415, a carbapenem-resistant Acinetobacter baumannii isolate containing four AbaR4 and a new variant of AbGRI2, represents a novel global clone 2 strain', Journal of Antimicrobial Chemotherapy, vol. 77, no. 2, pp. 345-350. Lim, JH, Wang, JQ, Webb, F, Saxena, K, Enosi Tuipulotu, D, Pandey, A, Man, SM & Talaulikar, D 2022, 'Plasma cells arise from differentiation of clonal lymphocytes and secrete IgM in Waldenström macroglobulinemia', iScience, vol. 25, no. 8, pp. 104856-104856. Lin, J-X, Siriviboon, P, Scammell, HD, Liu, S, Rhodes, D, Watanabe, K, Taniguchi, T, Hone, J, Scheurer, MS & Li, JIA 2022, 'Zero-field superconducting diode effect in small-twist-angle trilayer graphene', Nature Physics, vol. 18, no. 10, pp. 1221-1227. The critical current of a superconductor can be different for opposite directions of current flow when both time-reversal and inversion symmetry are broken. Such non-reciprocal behaviour creates a superconducting diode and has recently been experimentally demonstrated by breaking these symmetries with an applied magnetic field or by the construction of a magnetic tunnel junction. Here we report an intrinsic superconducting diode effect that is present at zero external magnetic field in mirror-symmetric twisted trilayer graphene. Such non-reciprocal behaviour, with sign that can be reversed through training with an out-of-plane magnetic field, provides direct evidence of the microscopic coexistence between superconductivity and time-reversal symmetry breaking. In addition to the magnetic-field trainability, we show that the zero-field diode effect can be controlled by varying the carrier density or twist angle. A natural interpretation for the origin of the intrinsic diode effect is an imbalance in the valley occupation of the underlying Fermi surface, which probably leads to finite-momentum Cooper pairing and nematicity in the superconducting phase. Liu, B, Liao, J, Song, Y, Chen, C, Ding, L, Lu, J, Zhou, J & Wang, F 2022, 'Multiplexed structured illumination super-resolution imaging with lifetime-engineered upconversion nanoparticles', Nanoscale Advances, vol. 4, no. 1, pp. 30-38. Liu, G, Jarnicki, AG, Paudel, KR, Lu, W, Wadhwa, R, Philp, AM, Van Eeckhoutte, H, Marshall, JE, Malyla, V, Katsifis, A, Fricker, M, Hansbro, NG, Dua, K, Kermani, NZ, Eapen, MS, Tiotiu, A, Chung, KF, Caramori, G, Bracke, K, Adcock, IM, Sohal, SS, Wark, PA, Oliver, BG & Hansbro, PM 2022, 'Adverse roles of mast cell chymase-1 in COPD', European Respiratory Journal, vol. 60, no. 6, pp. 2101431-2101431. Liu, H, Lai, W, Lei, Y, Yang, H, Wang, N, Chou, S, Liu, HK, Dou, SX & Wang, Y 2022, 'Electrolytes/Interphases: Enabling Distinguishable Sulfur Redox Processes in Room‐Temperature Sodium‐Sulfur Batteries', Advanced Energy Materials, vol. 12, no. 6, pp. 2103304-2103304. Liu, H, Mendelson, N, Abidi, IH, Li, S, Liu, Z, Cai, Y, Zhang, K, You, J, Tamtaji, M, Wong, H, Ding, Y, Chen, G, Aharonovich, I & Luo, Z 2022, 'Rational Control on Quantum Emitter Formation in Carbon-Doped Monolayer Hexagonal Boron Nitride', ACS Applied Materials & Interfaces, vol. 14, no. 2, pp. 3189-3198. Liu, S, Teng, Z, Liu, H, Wang, T, Wang, G, Xu, Q, Zhang, X, Jiang, M, Wang, C, Huang, W & Pang, H 2022, 'A Ce‐UiO‐66 Metal–Organic Framework‐Based Graphene‐Embedded Photocatalyst with Controllable Activation for Solar Ammonia Fertilizer Production', Angewandte Chemie International Edition, vol. 61, no. 37, p. e202207026. Liu, T, Zhang, W, Li, J, Ueland, M, Forbes, SL, Zheng, WX & Su, SW 2022, 'A Multiscale Wavelet Kernel Regularization-Based Feature Extraction Method for Electronic Nose', IEEE Transactions on Systems, Man, and Cybernetics: Systems, vol. 52, no. 11, pp. 7078-7089. Liu, Y, Li, Y, Carroll, RJ & Wang, N 2022, 'Predictive functional linear models with diverging number of semiparametric single-index interactions', Journal of Econometrics, vol. 230, no. 2, pp. 221-239. Liu, Y, Zhang, X, Zhang, L, Oliver, BG, Wang, HG, Liu, ZP, Chen, ZH, Wood, L, Hsu, AC-Y, Xie, M, McDonald, V, Wan, HJ, Luo, FM, Liu, D, Li, WM & Wang, G 2022, 'Sputum Metabolomic Profiling Reveals Metabolic Pathways and Signatures Associated With Inflammatory Phenotypes in Patients With Asthma', Allergy, Asthma & Immunology Research, vol. 14, no. 4, pp. 393-393. PURPOSE: The molecular links between metabolism and inflammation that drive different inflammatory phenotypes in asthma are poorly understood. We aimed to identify the metabolic signatures and underlying molecular pathways of different inflammatory asthma phenotypes. METHODS: In the discovery set (n = 119), untargeted ultra-high-performance liquid chromatography-mass spectrometry (UHPLC-MS) was applied to characterize the induced sputum metabolic profiles of asthmatic patients with different inflammatory phenotypes using orthogonal partial least-squares discriminant analysis (OPLS-DA), and pathway topology enrichment analysis. In the validation set (n = 114), differential metabolites were selected to perform targeted quantification. Correlations between targeted metabolites and clinical indices in asthmatic patients were analyzed. Logistic and negative binomial regression models were established to assess the association between metabolites and severe asthma exacerbations. RESULTS: Seventy-seven differential metabolites were identified in the discovery set. Pathway topology analysis uncovered that histidine metabolism, glycerophospholipid metabolism, nicotinate and nicotinamide metabolism, linoleic acid metabolism as well as phenylalanine, tyrosine and tryptophan biosynthesis were involved in the pathogenesis of different asthma phenotypes. In the validation set, 24 targeted quantification metabolites were significantly expressed between asthma inflammatory phenotypes. Finally, adenosine 5'-monophosphate (adjusted relative risk [adj RR] = 1.000; 95% confidence interval [CI] = 1.000-1.000; P = 0.050), allantoin (adj RR = 1.000; 95% CI = 1.000-1.000; P = 0.043) and nicotinamide (adj RR = 1.001; 95% CI = 1.000-1.002; P = 0.021) were demonstrated to predict severe asthma exacerbation rates. CONCLUSIONS: Different inflammatory asthma phenotypes have specific metabolic profiles in induced sputum. The potential metabolic signatures may identify therapeutic tar... Long, MQ, Tang, KK, Xiao, J, Li, JY, Chen, J, Gao, H, Chen, WH, Liu, CT & Liu, H 2022, 'Recent advances on MXene based materials for energy storage applications', Materials Today Sustainability, vol. 19, pp. 100163-100163. Luo, Y, Chen, Z, Wen, S, Han, Q, Fu, L, Yan, L, Jin, D, Bünzli, J-CG & Bao, G 2022, 'Magnetic regulation of the luminescence of hybrid lanthanide-doped nanoparticles', Coordination Chemistry Reviews, vol. 469, pp. 214653-214653. The unique optical properties of lanthanide-doped nanomaterials have made them broadly attractive to a wide range of applications in chemical, physical, and biomedical fields. As an external and real-time regulation tool, the magnetic field is highly useful for modulating the luminescence of lanthanide ions by spectral splitting, wavelength shifting, and intensity variation. The dynamic regulation of the luminescence further endows the nanosystems with many valuable optical features, extending their versatility. Here, we analyze the magnetic regulation mechanisms of luminescence, survey the structure design of magnetooptic nanosystems, highlight their advances in imaging agents, responsive probes, nanomagnets and nanogenerators, microrobots, and miniature reactors; we also identify the challenges and future opportunities for hybrid magnetooptic nanosystems. Luu, LDW & Lan, R 2022, 'Rapid Surface Shaving for Proteomic Identification of Novel Surface Antigens for Vaccine Development', Methods Mol Biol, vol. 2414, pp. 47-62. The bacterial cell surface (surfaceome) is the first site encountered by immune cells and is thus an important site for immune recognition. As such, the characterization of bacterial surface proteins can lead to the discovery of novel antigens for potential vaccine development. In this chapter, we describe a rapid 5-min surface shaving proteomics protocol where live bacterial cells are incubated with trypsin and surface peptides are 'shaved' off. The shaved peptides are subsequently identified with liquid chromatography-tandem mass spectrometry (LC-MS/MS). Several checkpoints, including colony forming unit (CFU) counts, flow cytometry, and a false positive unshaved control, are introduced to ensure cell viability/membrane integrity are maintained and that proteins identified are true surface proteins. The protein topology of shaved peptides can be bioinformatically confirmed for surface location. Surface shaving facilitates identification of surface proteins expressed under different conditions, by different strains as well as highly abundant essential and immunogenic bacterial surface antigens for potential vaccine development. Luu, LDW, Popple, G, Tsang, SPW, Vinasco, K, Hilmi, I, Ng, RT, Chew, KS, Wong, SY, Riordan, S, Lee, WS, Mitchell, HM, Kaakoush, NO & Castaño‐Rodríguez, N 2022, 'Genetic variants involved in innate immunity modulate the risk of inflammatory bowel diseases in an understudied Malaysian population', Journal of Gastroenterology and Hepatology, vol. 37, no. 2, pp. 342-351. Luu, LDW, Singh, H, Castaño-Rodríguez, N, Leach, ST, Riordan, SM, Tedla, N, Krishnan, U & Kaakoush, NO 2022, 'Changes to the upper gastrointestinal microbiotas of children with reflux oesophagitis and oesophageal metaplasia', Microbial Genomics, vol. 8, no. 9, pp. 1-12. Macreadie, LK, Gilchrist, AM, McNaughton, DA, Ryder, WG, Fares, M & Gale, PA 2022, 'Progress in anion receptor chemistry', Chem, vol. 8, no. 1, pp. 46-118. This review covers advances made in anion complexation in the years 2019 and 2020. Included here are developments in self-assembly, sensing, anion separation, transport, catalysis, and fundamental advances in anion recognition systems. Mahmud, MA, Duong, T, Peng, J, Wu, Y, Shen, H, Walter, D, Nguyen, HT, Mozaffari, N, Tabi, GD, Catchpole, KR, Weber, KJ & White, TP 2022, 'Origin of Efficiency and Stability Enhancement in High‐Performing Mixed Dimensional 2D‐3D Perovskite Solar Cells: A Review', Advanced Functional Materials, vol. 32, no. 3. Mahmud, MAP & Farjana, SH 2022, 'Comparative life cycle environmental impact assessment of renewable electricity generation systems: A practical approach towards Europe, North America and Oceania', Renewable Energy, vol. 193, pp. 1106-1120. Mahmud, MAP, Adhikary, P, Zolfagharian, A, Adams, S, Kaynak, A & Kouzani, AZ 2022, 'Advanced Design, Fabrication, and Applications of 3D-Printable Piezoelectric Nanogenerators', Electronic Materials Letters, vol. 18, no. 2, pp. 129-144. Mahmud, MAP, Bazaz, SR, Dabiri, S, Mehrizi, AA, Asadnia, M, Warkiani, ME & Wang, ZL 2022, 'Advances in MEMS and Microfluidics‐Based Energy Harvesting Technologies', Advanced Materials Technologies, vol. 7, no. 7, pp. 2101347-2101347. Maitre, M, Horder, M, Kirkbride, KP, Gassner, A-L, Weyermann, C, Gupta, A, Beavis, A & Roux, C 2022, 'An application example of the likelihood ratio approach to the evaluation of organic gunshot residues using a fictional scenario and recently published data', Forensic Science International, vol. 335, pp. 111267-111267. Malik, S, Ashraf, MUF, Shahid, A, Javed, MR, Khan, AZ, Usman, M, Manivannan, A, Mehmood, MA & Ashraf, GA 2022, 'Characterization of a newly isolated self-flocculating microalga Bracteacoccus pseudominor BERC09 and its evaluation as a candidate for a multiproduct algal biorefinery', Chemosphere, vol. 304, pp. 135346-135346. Microalgae have the highest capability to fix the atmospheric carbon and wastewater-derived nutrients to produce high-value bioproducts including lipids and carotenoids. However, their lower titers and single-product-oriented biomass processing have made the overall process expensive. Hence, increased metabolite titer and processing of the biomass for more than one product are required to ensure the commercial robustness of the algal biorefinery. In this study, a newly isolated algal strain was identified as Bracteacoccus pseudominor BERC09 through phylogenetic analysis based on the 18S rRNA gene sequence. Basic characterization of the strain revealed its promising potential to produce carotenoids and lipids. The lipids and carotenoid biosynthesis pathways of BERC09 were further triggered by manipulating the abiotic factors including nitrogen sources (NaNO3, KNO3, NH4Cl, Urea), nitrogen concentrations (0.06-0.36 gL-1), light intensity (150 μmolm-2s-1 to 300 μmolm-2s-1), and light quality (white and blue). Resultantly, 300 μmolm-2s-1 of blue light yielded 0.768 gL-1 of biomass, 8.4 mgg-1 of carotenoids, and 390 mgg-1 of lipids, and supplementation of 0.36 gL-1 of KNO3 further improved metabolism and yielded 0.814 gL-1 of biomass, 11.86 mgg-1 of carotenoids, and 424 mgg-1 of lipids. Overall, the optimal combination of light and nitrogen concurrently improved biomass, carotenoids, and lipids by 3.5-fold, 6-fold, and 4-fold than control, respectively. Besides, the excellent glycoproteins-based self-flocculation ability of the strain rendered an easier harvesting via gravity sedimentation. Hence, this biomass can be processed in a cascading fashion to use this strain as a candidate for a multiproduct biorefinery to achieve commercial robustness and environmental sustainability. Malik, S, Shahid, A, Betenbaugh, MJ, Liu, C-G & Mehmood, MA 2022, 'A novel wastewater-derived cascading algal biorefinery route for complete valorization of the biomass to biodiesel and value-added bioproducts', Energy Conversion and Management, vol. 256, pp. 115360-115360. Integration of multiproduct algal biorefineries with wastewater treatment systems could offer a sustainable approach to produce green products in a circular bioeconomy paradigm while keeping the water-energy-environment nexus sustainable. The present study demonstrated a novel biorefinery route employing a newly isolated self-flocculating microalga Chlamydomonas sp. BERC07. Here, the urban wastewater served as a low-cost growth media and improved biomass production (1.24 g/L) by 2-fold with concomitant removal of 100% total nitrogen, 94% total phosphorus, 56% COD, and 41% BOD. To lower the harvesting cost, an inducible sedimentation-based harvesting system was developed by employing the lowest dose of a commercial-grade flocculant, potash alum (0.27 kg/1000L culture) which improved the sedimentation rate of algal flocs by 240-fold with a biomass recovery efficiency of 96–98%. Later, the wastewater-derived biomass was subjected to downstream processing in a cascading fashion for its complete valorization. The biomass yielded 1.83 mg/g of carotenoids and 480 mg/g of lipids. The lipids were transesterified to produce biodiesel which completely met the preset European and American biodiesel quality standards. After carotenoids and lipids extraction, the residual biomass was fermented using Aspergillus niger and Aspergillus oryzae for the very first time. Interestingly, the A. oryzae outcompeted the A. niger and produced 131.6 U/mL of α-amylase along with 375–384 mg/g of mycoproteins utilizing 75–100 g/L of the residual algal biomass as a sole feedstock. All solvents involved in the product recovery were recycled to the primary wastewater, leaving no waste at the end of the processing pipeline. Overall, the data demonstrated a novel and sustainable biorefinery route with the most efficient harvesting and the complete valorization of the biomass, in a zero-waste approach. However, further upscaling, life cycle assessment, and technoeconomic analyses will be required to... Malik, S, Shahid, A, Haider, MN, Amin, M, Betenbaugh, MJ, Mehmood, MA, Haq, MAU, Syafiuddin, A & Boopathy, R 2022, 'Prospects of Multiproduct Algal Biorefineries Involving Cascading Processing of the Biomass Employing a Zero-Waste Approach', Current Pollution Reports, vol. 8, no. 2, pp. 147-158. Purpose of Review: Increasing environmental problems demand mitigation solutions to fulfill sustainability development goals. Microalgae offer possibility of valorizing the CO2 and wastewater-derived nutrients to produce numerous industrial bioproducts. However, developing self-sustained systems for the complete valorization of algal biomass into valuable biobased products is challenging. Currently, sustainable algal processing faces several challenges including costly cultivation, difficult harvesting, and incomplete biomass valorization. This review assessed the prospects of emerging technologies focusing on the integrated approaches for sustainable algal biorefinery development ensuring the sustainability of environment-water-energy nexus. Recent Findings: Evaluation of various upstream, midstream, and downstream processing technologies provided insights into the processing issues. In upstream processing, high-rate algal ponds and integrated carbon capture and transformation technologies offer waste valorization into eco-friendly algal production. A brief comparison of harvesting technologies mainly focusing on chemical and biological flocculation has shown that integrating physical and biological harvesting methods are more reliable and efficient. Overview of downstream processing has indicated that biomass processing in a cascading manner offers the complete biomass valorization in a zero-waste paradigm. Summary: Assessment of cultivation-to-production technologies highlighted that “zero-waste” algal biorefinery has the potential to become reality by integrating the industry 4.0 and phenomics approaches with eco-friendly cultivation, harvesting, and processing technologies. Hybrid methods based on integrated cascading processing offer complete biomass valorization in a circular bioeconomy paradigm. Graphical Abstract: [Figure not available: see fulltext.] Mallen‐Cooper, M, Atkinson, J, Xirocostas, ZA, Wijas, B, Chiarenza, GM, Dadzie, FA & Eldridge, DJ 2022, 'Global synthesis reveals strong multifaceted effects of eucalypts on soils', Global Ecology and Biogeography, vol. 31, no. 8, pp. 1667-1678. Manandhar, B, Paudel, KR, Panth, N, Hansbro, P, Oliver, BG & Dua, K 2022, 'Applications of Extracellular Vesicles as A Drug-Delivery System for Chronic Respiratory Diseases', Nanomedicine, vol. 17, no. 12, pp. 817-820. Mann, R, Rafei, R, Gunawan, C, Harmer, CJ & Hamidian, M 2022, 'Variants of Tn 6924 , a Novel Tn 7 Family Transposon Carrying the bla NDM Metallo-β-Lactamase and 14 Copies of the aphA6 Amikacin Resistance Genes Found in Acinetobacter baumannii', Microbiology Spectrum, vol. 10, no. 1. Marlton, FP, Mullens, BG, Chater, PA & Kennedy, BJ 2022, 'Tetrahedral Displacive Disorder in the Scheelite-Type Oxide RbReO4', Inorganic Chemistry, vol. 61, no. 38, pp. 15130-15137. Maslin, LA, Weeks, BR, Carroll, RJ, Byrne, DH & Turner, ND 2022, 'Chlorogenic Acid and Quercetin in a Diet with Fermentable Fiber Influence Multiple Processes Involved in DSS-Induced Ulcerative Colitis but Do Not Reduce Injury', Nutrients, vol. 14, no. 18, pp. 3706-3706. Mathew, M, Rad, MA, Mata, JP, Mahmodi, H, Kabakova, IV, Raston, CL, Tang, Y, Tipper, JL & Tavakoli, J 2022, 'Hyperbranched polymers tune the physicochemical, mechanical, and biomedical properties of alginate hydrogels', Materials Today Chemistry, vol. 23, pp. 100656-100656. The current research aimed to fabricate an alginate-hyperbranched polymer (HBP) complex, using a vortex fluidic device (VFD), to control the physicochemical, structural, and mechanical properties of alginate hydrogel; thus, providing a dominant biomaterial system for different biomedical applications. Samples were prepared by mixing alginate (6%w/w) with HBP (0.85 μM) before cross-linking with Ca2+ (100 mM). Magnet stirrer (600 rpm) and VFD (6000 rpm) were used to prepare experimental samples, and alginate was used as control. Comprehensive evaluations of bulk and surface morphology, microstructural analysis, swelling kinetics, mechanical characteristics, cytotoxicity, and formation of hydrogen bonds were conducted. The findings from this study revealed that the addition of HBP to alginate structure led to a higher swelling capability (86%), increased diffusion coefficient (66-fold), and enhanced failure mechanical properties (160% and 20% increases for failure stress and elongation at break, respectively) than control. Traditional mixing affected the surface morphology, while the bulk structure remained unchanged. Moreover, the rate of degradation was not significantly different between alginate and alginate-HBP samples. When VFD was incorporated, a higher swelling ratio (30%) was observed than the control sample and the coefficient of diffusion increased (34-fold). 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Further benefiting from the minimized scattering through the NIR-IIb window, we enhanced the spatial resolution to ∼1 mm in GI tract imaging, which is ∼3 times higher compared with the near-infrared-IIa (NIR-IIa, 1000-1500 nm) method. The approach also realized a high temporal resolution of 8 frames per second; thus the moment of mice intestinal peristalsis can be captured. Furthermore, with a light-sheet imaging system, we demonstrated a three-dimensional (3D) imaging on the GI tract. Moreover, we successfully translated these advances to diagnose inflammatory bowel disease. Mitchell, A, Booth, DJ & Nagelkerken, I 2022, 'Ocean warming and acidification degrade shoaling performance and lateralization of novel tropical–temperate fish shoals', Global Change Biology, vol. 28, no. 4, pp. 1388-1401. 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Morgan, AL, Torpy, FR, Irga, PJ, Fleck, R, Gill, RL & Pettit, T 2022, 'The botanical biofiltration of volatile organic compounds and particulate matter derived from cigarette smoke', Chemosphere, vol. 295, pp. 133942-133942. Morshedi Rad, D, Rezaei, M, Radfar, P & Ebrahimi Warkiani, M 2022, 'Microengineered filters for efficient delivery of nanomaterials into mammalian cells', Scientific Reports, vol. 12, no. 1, p. 4383. Munawar, HS, Mojtahedi, M, Hammad, AWA, Kouzani, A & Mahmud, MAP 2022, 'Disruptive technologies as a solution for disaster risk management: A review', Science of The Total Environment, vol. 806, pp. 151351-151351. Murzakhanov, FF, Mamin, GV, Orlinskii, SB, Gerstmann, U, Schmidt, WG, Biktagirov, T, Aharonovich, I, Gottscholl, A, Sperlich, A, Dyakonov, V & Soltamov, VA 2022, 'Electron–Nuclear Coherent Coupling and Nuclear Spin Readout through Optically Polarized VB– Spin States in hBN', Nano Letters, vol. 22, no. 7, pp. 2718-2724. Coherent coupling of defect spins with surrounding nuclei along with the endowment to read out the latter are basic requirements for an application in quantum technologies. We show that negatively charged boron vacancies (VB-) in hexagonal boron nitride (hBN) meet these prerequisites. We demonstrate Hahn-echo coherence of the VB- spin with a characteristic decay time Tcoh = 15 μs, close to the theoretically predicted limit of 18 μs for defects in hBN. Elongation of the coherence time up to 36 μs is demonstrated by means of the Carr-Purcell-Meiboom-Gill decoupling technique. Modulation of the Hahn-echo decay is shown to be induced by coherent coupling of the VB- spin with the three nearest 14N nuclei via a nuclear quadrupole interaction of 2.11 MHz. DFT calculation confirms that the electron-nuclear coupling is confined to the defective layer and stays almost unchanged with a transition from the bulk to the single layer. 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Nguyen, LN, Aditya, L, Vu, HP, Johir, AH, Bennar, L, Ralph, P, Hoang, NB, Zdarta, J & Nghiem, LD 2022, 'Nutrient Removal by Algae-Based Wastewater Treatment', Current Pollution Reports, vol. 8, no. 4, pp. 369-383. Nguyen, LN, Vu, HP, Fu, Q, Abu Hasan Johir, M, Ibrahim, I, Mofijur, M, Labeeuw, L, Pernice, M, Ralph, PJ & Nghiem, LD 2022, 'Synthesis and evaluation of cationic polyacrylamide and polyacrylate flocculants for harvesting freshwater and marine microalgae', Chemical Engineering Journal, vol. 433, pp. 133623-133623. This study addresses the challenge of microalgae harvesting through the development of flocculants. Two positively charged cationic polymers including poly[2 (acryloyloxy)ethyl]trimethylammonium chloride (PAETAC) and poly(3 acrylamidopropyl)trimethylammonium chloride (PAmPTAC) were synthesized using the UV-induced radical polymerization, for harvesting both freshwater and marine microalgae. The results show that the synthesized polymers have excellent flocculation performance for both freshwater green microalgae (Chlorella vulgaris) and marine red microalgae (Porphyridium purpureum). PAETAC outperformed PAmPTAC for both Chlorella vulgaris and Porphyridium purpureum microalgae. The optimal PAETAC doses for Chlorella vulgaris and Porphyridium purpureum microalgae were 50 and 4.8 mg/g of dry biomass while the optimal PAmPTAC doses were 252 and 35 mg/g of dry biomass respectively. Additionally, the floc formation with the PAETAC was more stable than PAmPTAC, which supported the dewatering step via sieving. The superior performance can be attributed to the higher molecular weight of the PAETAC polymer when compared to the PAmPTAC polymer. In comparison to commercially available polydiallyldimethylammonium chloride (PolyDADMAC), the newly synthesised PAETAC and PAmPTAC polymers demonstrated superior flocculation efficiency at a lower dose. 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Results indicated that sorption/desorption of most of the shorter-carbon-chain PFASs (C ≤ 6) in soil reached greater than 99% rapidly─after approximately two pore volumes (PVs) and were well predicted by an equilibrium transport model, indicating that they will be readily removed by soil washing technologies. In contrast, the equilibrium model failed to predict the mobilization of longer-chain PFASs (C ≥ 7), indicating the presence of nonequilibrium sorption/desorption (confirmed by a flow interruption experiment). The actual time taken to attain 99% sorption/desorption was up to 5 times longer than predicted by the equilibrium model (e.g., ∼62 PVs versus ∼12 PVs predicted for perfluorooctane sulfonate (PFOS) in loamy sand). The increasing contribution of hydrophobic interactions over the electrostatic interactions is suggested as the main driving factor of the nonequilibrium processes. The inverse linear relationship (R2 = 0.6, p < 0.0001) between the nonequilibrium mass transfer rate coefficient and the Freundlich sorption coefficient could potentially be a useful means for preliminary evaluation of potential nonequilibrium sorption/desorption of PFASs in soils. Nicolle, P, Hughes, J, Fowler, A & Schilling, HT 2022, 'Long-term increase in growth of an estuarine predator, mulloway Argyrosomus japonicus, predicted to continue under future warming scenarios', Marine Ecology Progress Series, vol. 688, pp. 1-17. Nielsen, JJV, Matthews, G, Frith, KR, Harrison, HB, Marzonie, MR, Slaughter, KL, Suggett, DJ & Bay, LK 2022, 'Experimental considerations of acute heat stress assays to quantify coral thermal tolerance', Scientific Reports, vol. 12, no. 1, pp. 1-13. Nitschke, MR, Rosset, SL, Oakley, CA, Gardner, SG, Camp, EF, Suggett, DJ & Davy, SK 2022, 'The diversity and ecology of Symbiodiniaceae: A traits-based review', Advances in Marine Biology, vol. 92, pp. 55-127. Among the most successful microeukaryotes to form mutualisms with animals are dinoflagellates in the family Symbiodiniaceae. These photosynthetic symbioses drive significant primary production and are responsible for the formation of coral reef ecosystems but are particularly sensitive when environmental conditions become extreme. Annual episodes of widespread coral bleaching (disassociation of the mutualistic partnership) and mortality are forecasted from the year 2060 under current trends of ocean warming. However, host cnidarians and dinoflagellate symbionts display exceptional genetic and functional diversity, and meaningful predictions of the future that embrace this biological complexity are difficult to make. A recent move to trait-based biology (and an understanding of how traits are shaped by the environment) has been adopted to move past this problem. The aim of this review is to: (1) provide an overview of the major cnidarian lineages that are symbiotic with Symbiodiniaceae; (2) summarise the symbiodiniacean genera associated with cnidarians with reference to recent changes in taxonomy and systematics; (3) examine the knowledge gaps in Symbiodiniaceae life history from a trait-based perspective; (4) review Symbiodiniaceae trait variation along three abiotic gradients (light, nutrients, and temperature); and (5) provide recommendations for future research of Symbiodiniaceae traits. We anticipate that a detailed understanding of traits will further reveal basic knowledge of the evolution and functional diversity of these mutualisms, as well as enhance future efforts to model stability and change in ecosystems dependent on cnidarian-dinoflagellate organisms. Nolan, RH, Collins, L, Gibson, RK, Samson, SA, Rolls, KT, Milner, K, Medlyn, BE, Price, OF, Griebel, A, Choat, B, Jiang, M & Boer, MM 2022, 'The carbon cost of the 2019–20 Australian fires varies with fire severity and forest type', Global Ecology and Biogeography, vol. 31, no. 10, pp. 2131-2146. Nolan, RH, Foster, B, Griebel, A, Choat, B, Medlyn, BE, Yebra, M, Younes, N & Boer, MM 2022, 'Drought-related leaf functional traits control spatial and temporal dynamics of live fuel moisture content', Agricultural and Forest Meteorology, vol. 319, pp. 108941-108941. Large forest fires generally occur when the moisture content of fuels is low. For live fuels, our understanding of the physiological basis of variation in moisture content has recently advanced. However, process-based models of live fuel moisture content (LFMC) remain elusive. Here, we aim to further our understanding of the role of physiological mechanisms and plant functional traits in driving spatiotemporal variations in LFMC. We examined whether temporal variation in LFMC could be predicted from pressure-volume curve data, which measures leaf water potential and water content on cut shoots dehydrating on a bench. We also examined whether leaf dry mass traits could predict spatial variation in maximum LFMC. We undertook our study in eucalypt forests and woodlands spanning a large climatic gradient in eastern Australia. We found that LFMC models developed from pressure-volume curves reliably predicted seasonal variation in LFMC across four co-occurring species. A two-phase LFMC model, which fit models above and below the turgor loss point (mean absolute error = 3.7-33.2%), performed similarly well to a simple linear model (mean absolute error = 3.4-35.3%). Across a large climatic gradient, the maximum LFMC of 16 species was correlated with specific leaf area (R2 = 0.54), with the exception of one species with terete terminal stems. Maximum LFMC was highly correlated with aridity (R2 = 0.82), with lower LFMC observed in more arid sites. Our study demonstrates that spatiotemporal dynamics of LFMC are governed by both leaf dry mass traits and the relationship between leaf water potential and water content, which in turn is determined by traits such as cell wall elasticity. Thus, incorporating these traits into models of LFMC, whether these models are based on drought indices, soil moisture, or remotely sensed imagery, is likely to improve overall model performance, and subsequently improve forecasts of wildfire danger. Nonahal, M, Li, C, Tjiptoharsono, F, Ding, L, Stewart, C, Scott, J, Toth, M, Ha, ST, Kianinia, M & Aharonovich, I 2022, 'Coupling spin defects in hexagonal boron nitride to titanium dioxide ring resonators', Nanoscale, vol. 14, no. 40, pp. 14950-14955. Nouman, M, Khoo, SY, Mahmud, MAP & Kouzani, AZ 2022, 'Recent Advances in Contactless Sensing Technologies for Mental Health Monitoring', IEEE Internet of Things Journal, vol. 9, no. 1, pp. 274-297. The process of monitoring mental health has relied on methods, such as invasive sensing and self-reporting. The use of these methods has been limited because of the invasiveness of sensing devices or the subjective nature of patients' responses. Recent research focuses on the contactless sensing methods used to objectively monitor mental health issues. These methods allow continuous collection of real-time data in a nondisruptive manner. Machine learning methods are then applied to the sensed data to predict information, such as physical activity, gestures, and heart rate. This information can be then used to assess mental health issues, such as depression, stress, and anxiety, among others. This article presents a comprehensive review of contactless sensing methods for mental health monitoring. It investigates the published research that focuses on contactless sensing methods to predict mental health condition. Moreover, this review categorizes the applications of contactless sensing methods into detection, recognition, and monitoring of vital signs. Furthermore, a comparison of recent studies on contactless sensing methods is presented, which shows the effectiveness and reliability of these methods. This study also highlights the existing challenges in contactless sensing methods and provides future research directions to mitigate these challenges. NUCERA, F, MUMBY, S, PAUDEL, KR, DHARWAL, V, DI STEFANO, A, CASOLARO, V, HANSBRO, PM, ADCOCK, IM & CARAMORI, G 2022, 'Role of oxidative stress in the pathogenesis of COPD', Minerva Medica, vol. 113, no. 3. Nunes, MH, Camargo, JLC, Vincent, G, Calders, K, Oliveira, RS, Huete, A, Mendes de Moura, Y, Nelson, B, Smith, MN, Stark, SC & Maeda, EE 2022, 'Forest fragmentation impacts the seasonality of Amazonian evergreen canopies', Nature Communications, vol. 13, no. 1, p. 917. O’Brien, J, McParland, EL, Bramucci, AR, Ostrowski, M, Siboni, N, Ingleton, T, Brown, MV, Levine, NM, Laverock, B, Petrou, K & Seymour, J 2022, 'The Microbiological Drivers of Temporally Dynamic Dimethylsulfoniopropionate Cycling Processes in Australian Coastal Shelf Waters', Frontiers in Microbiology, vol. 13, pp. 1-19. O’Brien, J, McParland, EL, Bramucci, AR, Siboni, N, Ostrowski, M, Kahlke, T, Levine, NM, Brown, MV, van de Kamp, J, Bodrossy, L, Messer, LF, Petrou, K & Seymour, JR 2022, 'Biogeographical and seasonal dynamics of the marine Roseobacter community and ecological links to DMSP-producing phytoplankton', ISME Communications, vol. 2, no. 1, p. 16. O’Donnell, AW, Redmond, G, Arciuli, J, Robinson, S, Skattebol, J, Raghavendra, P, Thomson, C, Wang, JJJ & Emerson, E 2022, 'The Association between Parental Educational Expectations and School Functioning among Young People with Disabilities: A Longitudinal Investigation', Exceptional Children, vol. 89, no. 1, pp. 60-78. O’Rourke, MB, Roediger, BR, Jolly, CJ, Crossett, B, Padula, MP & Hansbro, PM 2022, 'Viral Biomarker Detection and Validation Using MALDI Mass Spectrometry Imaging (MSI)', Proteomes, vol. 10, no. 3, pp. 33-33. O'Brien, J, Focardi, A, Deschaseaux, ESM, Petrou, K, Ostrowski, M, Beckley, LE & Seymour, JR 2022, 'Microbial dimethylsulfoniopropionate (DMSP) cycling in the ultraoligotrophic eastern Indian Ocean', Deep Sea Research Part II: Topical Studies in Oceanography, vol. 206, pp. 105195-105195. Dimethylsulfoniopropionate (DMSP) is an important source of dissolved organic matter for the marine food web and its cycling is a key step in ocean-atmosphere fluxes involved in the global sulfur cycle. To date, the abundance and biogeography of the genes encoding bacterial DMSP cycling in the eastern Indian Ocean (EIO) is virtually unknown. Moreover, DMSP measurements from the IO are sparse compared to other major oceans. In May–June 2019, we characterized dissolved DMSP (DMSPd) concentrations and the abundance of representative bacterial DMSP cycling genes along the 110 °E transect line as part of a voyage that contributed to Australia's involvement in the second International Indian Ocean Expedition. During the multidisciplinary voyage, surface water samples were collected from 19 stations spanning temperate to tropical waters of the EIO (39.5 °S to 11.5 °S, 110 °E). Somewhat surprisingly, a trend of greater DMSPd was measured in ultraoligotrophic (<0.02 μmol L−1 of nitrate/nitrite), low latitude waters compared to relatively nutrient-rich high latitudes, which contradicts global DMSPd patterns of high concentrations at high latitudes. Additionally, the average DMSPd concentration in EIO samples (17.2 ± 18.64 nM) was an order of magnitude greater than concentrations previously reported at similar latitudes in the Pacific and Atlantic Oceans, which suggests DMSPd is a readily available food source for microbes in a region that is often considered an ocean desert. The abundances of the bacterial DMSP production gene (dsyB), the DMSP lyase gene (dddP) and phylogenetically diverse DMSP demethylation genes (dmdA subclade A/1, D/all and E/2) were reported for the first time in the EIO region, demonstrating significant shifts in all genes with latitude. The SAR11 dmdA (D/all) gene was the dominant DMSP degradation gene across the transect (3.4 ± 0.94% of bacteria) and was notably positively correlated to DMSPd, demonstrating a tight coupling between the var... O'Connell, MJ, Fowler, AM, Allan, SJ, Beretta, GA & Booth, DJ 2022, 'Recruiting a long way from home: Domino damselfish Dascyllus trimaculatus can detect new temperate coral habitat and conspecifics', Journal of Fish Biology, vol. 100, no. 6, pp. 1548-1552. O'Donnell, AW, Redmond, G, Thomson, C, Wang, JJJ & Turkmani, S 2022, 'Reducing educational disparities between Australian adolescents in regional and metropolitan communities: The compensatory effects of extracurricular activities.', Developmental Psychology, vol. 58, no. 12, pp. 2358-2371. Australian adolescents living in regional communities are significantly more likely to perform worse at school, relative to those in metropolitan communities. These disparities are partially due to the development of lower educational expectations among regional adolescents. In the current study, we tested whether the differences in educational expectations across communities were reduced when adolescents engage in extracurricular activities, and any subsequent downstream effects on academic outcomes. The current study used a subsample of 1,477 adolescents recruited as part of the Longitudinal Study of Australian Children who have graduated from high school. Using a random-intercept cross-lagged panel model, we found that residing in a regional community at the start of secondary education predicted worse academic performance when graduating 6 years later. This association was partially mediated by lower educational expectations and school functioning, measured biennially. However, the significant difference between adolescents in metropolitan and regional communities dissipated when participants engaged in three or more types of extracurricular activities. These results highlight that increasing access and support to participate in extracurricular activities in regional communities may contribute to reducing inequities in educational outcomes. (PsycInfo Database Record (c) 2022 APA, all rights reserved). Oglobline, AN, Padula, MP & Doble, PA 2022, 'Quality control of A1-free dairy', Food Control, vol. 135, pp. 108685-108685. Onen, M, Emond, N, Wang, B, Zhang, D, Ross, FM, Li, J, Yildiz, B & del Alamo, JA 2022, 'Nanosecond protonic programmable resistors for analog deep learning', Science, vol. 377, no. 6605, pp. 539-543. Pai, TY, Meyer, W, Torpy, FR, Donahoe, SL, Ellis, J, Malik, R & Lee, R 2022, 'Host transmission dynamics of first- and third-stage Angiostrongylus cantonensis larvae in Bullastra lessoni', Parasitology, vol. 149, no. 8, pp. 1034-1044. Paijmans, KC, Booth, DJ & Wong, MYL 2022, 'Single-species subgroups form within mixed-species shoals of tropical and temperate fishes', Environmental Biology of Fishes, vol. 105, no. 12, pp. 1975-1988. Shoaling behaviour is commonly displayed by fishes and is thought to reduce predation and increase foraging efficiency. Shoaling relies on coordination between individuals, with higher cohesion and alignment among individuals within a shoal providing greater net benefits of this behaviour. Whilst single species often shoal together in conspecific groups, mixed-species shoaling is frequently observed and has been identified as an important determinant of individual fitness for the multiple species involved. Despite their prevalence, the structure of mixed-species shoals and the mechanisms by which individuals gain protection from predators and enhance their foraging efficiency are not as well understood as for single-species shoals. In fact, mixed-species shoals may be less coordinated than single-species shoals, raising the intriguing question of why fishes form mixed-species shoals when this behaviour could be less beneficial than single-species shoaling. Here we used in situ stereo-video techniques to compare within and between shoal differences in cohesion and alignment, for mixed- and single-species shoals containing the tropical vagrant Indo pacific sergeant major damselfish, Abudefduf vaigiensis, in temperate waters. As expected, mixed-species shoals were less aligned than single-species shoals. However, within mixed-species shoals conspecifics were more cohesive and aligned than were heterospecifics, suggesting coordinated single-species subgroups formed within larger mixed-species shoals. The formation of subgroups may mitigate costs associated with differences between species, therefore enhancing benefits of mixed-species shoaling. As such, multiple levels of social structure may exist within mixed-species shoals that could facilitate growth and survival for vagrant A. vaigiensis in temperate regions. More broadly, this research highlights the importance of considering detailed internal structures of mixed-species shoals when trying to understa... Palinski, RM, Brito, B, Jaya, FR, Sangula, A, Gakuya, F, Bertram, MR, Pauszek, SJ, Hartwig, EJ, Smoliga, GR, Obanda, V, Omondi, GP, VanderWaal, K & Arzt, J 2022, 'Viral Population Diversity during Co-Infection of Foot-And-Mouth Disease Virus Serotypes SAT1 and SAT2 in African Buffalo in Kenya', Viruses, vol. 14, no. 5, pp. 897-897. Pamphlett, R & Bishop, DP 2022, 'Mercury is present in neurons and oligodendrocytes in regions of the brain affected by Parkinson’s disease and co-localises with Lewy bodies', PLOS ONE, vol. 17, no. 1, pp. e0262464-e0262464. Pan, Y, Wang, Y, Zheng, S, Huete, AR, Shen, M, Zhang, X, Huang, J, He, G, Yu, L, Xu, X, Xie, Q & Peng, D 2022, 'Characteristics of Greening along Altitudinal Gradients on the Qinghai–Tibet Plateau Based on Time-Series Landsat Images', Remote Sensing, vol. 14, no. 10, pp. 2408-2408. Panthi, VK, Jha, SK, Pangeni, R & Paudel, KR 2022, 'Formulation and Development of Adapalene Topical Nanohydrogel Using Different Surfactants and Cosurfactants for Antiacne Activity: In Vitro and Ex Vivo Evaluation', Journal of Nanomaterials, vol. 2022, no. 1, pp. 1-19. Papanicolaou, M, Parker, AL, Yam, M, Filipe, EC, Wu, SZ, Chitty, JL, Wyllie, K, Tran, E, Mok, E, Nadalini, A, Skhinas, JN, Lucas, MC, Herrmann, D, Nobis, M, Pereira, BA, Law, AMK, Castillo, L, Murphy, KJ, Zaratzian, A, Hastings, JF, Croucher, DR, Lim, E, Oliver, BG, Mora, FV, Parker, BL, Gallego-Ortega, D, Swarbrick, A, O’Toole, S, Timpson, P & Cox, TR 2022, 'Temporal profiling of the breast tumour microenvironment reveals collagen XII as a driver of metastasis', Nature Communications, vol. 13, no. 1, p. 4587. Parast, L, Garcia, TP, Prentice, RL & Carroll, RJ 2022, 'Robust methods to correct for measurement error when evaluating a surrogate marker', Biometrics, vol. 78, no. 1, pp. 9-23. Pasin, D, Nedahl, M, Mollerup, CB, Tortzen, C, Reitzel, LA & Dalsgaard, PW 2022, 'Identification of the synthetic cannabinoid‐type new psychoactive substance, CH‐PIACA, in seized material', Drug Testing and Analysis, vol. 14, no. 9, pp. 1645-1651. Pasin, D, Pan, M, Rasmussen, BS, Linnet, K, Dalsgaard, PW & Mollerup, CB 2022, 'Metabolomics‐driven determination of targets for salicylic acid and ibuprofen in positive electrospray ionization using LC‐HRMS', Drug Testing and Analysis, vol. 14, no. 4, pp. 747-756. Pathinayake, PS, Waters, DW, Nichol, KS, Brown, AC, Reid, AT, Hsu, AC-Y, Horvat, JC, Wood, LG, Baines, KJ, Simpson, JL, Gibson, PG, Hansbro, PM & Wark, PAB 2022, 'Endoplasmic reticulum-unfolded protein response signalling is altered in severe eosinophilic and neutrophilic asthma', Thorax, vol. 77, no. 5, pp. 443-451. Paudel, KR, Dua, K, Panth, N, Hansbro, PM & Chellappan, DK 2022, 'Advances in Research With Rutin-Loaded Nanoformulations in Mitigating Lung Diseases', Future Medicinal Chemistry, vol. 14, no. 18, pp. 1293-1295. Paudel, KR, Mehta, M, Shukla, SD, Panth, N, Chellappan, DK, Dua, K & Hansbro, P 2022, 'Advancements in Nanotherapeutics Targeting Senescence in Chronic Obstructive Pulmonary Disease', Nanomedicine, vol. 17, no. 23, pp. 1757-1760. Paudel, KR, Mehta, M, Yin, GHS, Yen, LL, Malyla, V, Patel, VK, Panneerselvam, J, Madheswaran, T, MacLoughlin, R, Jha, NK, Gupta, PK, Singh, SK, Gupta, G, Kumar, P, Oliver, BG, Hansbro, PM, Chellappan, DK & Dua, K 2022, 'Berberine-loaded liquid crystalline nanoparticles inhibit non-small cell lung cancer proliferation and migration in vitro', Environmental Science and Pollution Research, vol. 29, no. 31, pp. 46830-46847. Paudel, KR, Patel, V, Vishwas, S, Gupta, S, Sharma, S, Chan, Y, Jha, NK, Shrestha, J, Imran, M, Panth, N, Shukla, SD, Jha, SK, Devkota, HP, Warkiani, ME, Singh, SK, Ali, MK, Gupta, G, Chellappan, DK, Hansbro, PM & Dua, K 2022, 'Nutraceuticals and COVID‐19: A mechanistic approach toward attenuating the disease complications', Journal of Food Biochemistry, vol. 46, no. 12, p. e14445. Nutraceuticals have emerged as potential compounds to attenuate the COVID-19 complications. Precisely, these food additives strengthen the overall COVID treatment and enhance the immunity of a person. Such compounds have been used at a large scale, in almost every household due to their better affordability and easy access. Therefore, current research is focused on developing newer advanced formulations from potential drug candidates including nutraceuticals with desirable properties viz, affordability, ease of availability, ease of administration, stability under room temperature, and potentially longer shelf-lives. As such, various nutraceutical-based products such as compounds could be promising agents for effectively managing COVID-19 symptoms and complications. Most importantly, regular consumption of such nutraceuticals has been shown to boost the immune system and prevent viral infections. Nutraceuticals such as vitamins, amino acids, flavonoids like curcumin, and probiotics have been studied for their role in the prevention of COVID-19 symptoms such as fever, pain, malaise, and dry cough. In this review, we have critically reviewed the potential of various nutraceutical-based therapeutics for the management of COVID-19. We searched the information relevant to our topic from search engines such as PubMed and Scopus using COVID-19, nutraceuticals, probiotics, and vitamins as a keyword. Any scientific literature published in a language other than English was excluded. PRACTICAL APPLICATIONS: Nutraceuticals possess both nutritional values and medicinal properties. They can aid in the prevention and treatment of diseases, as well as promote physical health and the immune system, normalizing body functions, and improving longevity. Recently, nutraceuticals such as probiotics, vitamins, polyunsaturated fatty acids, trace minerals, and medicinal plants have attracted considerable attention and are widely regarded as potential alternatives to current the... Paulowski, L, Beckham, KSH, Johansen, MD, Berneking, L, Van, N, Degefu, Y, Staack, S, Sotomayor, FV, Asar, L, Rohde, H, Aldridge, BB, Aepfelbacher, M, Parret, A, Wilmanns, M, Kremer, L, Combrink, K & Maurer, FP 2022, 'C25-modified rifamycin derivatives with improved activity against Mycobacterium abscessus', PNAS Nexus, vol. 1, no. 4, p. pgac130. Payne, M, Bottomley, AL, Och, A, Hiscocks, HG, Asmara, AP, Harry, EJ & Ung, AT 2022, 'Synthesis and biological evaluation of tetrahydroisoquinoline-derived antibacterial compounds', Bioorganic & Medicinal Chemistry, vol. 57, pp. 116648-116648. Antibiotic resistance is one of the greatest threats to modern medicine. Drugs that were once routinely used to treat infections are being rendered ineffective, increasing the demand for novel antibiotics with low potential for resistance. Here we report the synthesis of 18 novel cationic tetrahydroisoquinoline-triazole compounds. Five of the developed molecules were active against S. aureus at a low MIC of 2-4 μg/mL. Hit compound 4b was also found to eliminate M. tuberculosis H37Rv at MIC of 6 μg/mL. This potent molecule was found to eliminate S. aureus effectively, with no resistance observed after thirty days of sequential passaging. These results identified compound 4b and its analogues as potential candidates for further drug development that could help tackle the threat of antibiotic resistance. Peacock, L, Waszczuk, J, Raymond, J & Chadwick, S 2022, 'Investigating the Effectiveness of Chemical Etchanton Medium Carbon (0.40% C) Steel', AFTE Journal, vol. 54, no. 1, pp. 17-27. Serial number restoration allows forensic investigators to recover a potentially lost chain of ownership relating to a piece of evidence in an investigation. The ability to restore an obliterated serial number relies on the permanent residual stress left in the metal substrate from a cold working application of the stamped serial number. The application of chemical etching reagents is one method which is used to exploit this stress, and there are a number of different formulations available for this purpose. This research aimed to review and compile historically successful and other proposed etching reagents, to further understand how each formulation can be used more efficiently in the field of serial number restoration. The importance of the composition of the metal substrate being etched is well established, although from the current literature there is a lack of consistent knowledge surrounding which reagent should be used with specific metal compositions. This research intended to aid forensic investigators in determining the most suitable etching reagent for medium carbon (0.40%) steel. The efficacy of reagents at varying depths of obliteration on a consistently stamped steel substrate was tested. The standard Fry’s Reagent, consisting of 90 g copper (II) chloride, 120 mL hydrochloric acid and 100 mL deionized water with 15% nitric acid, was determined to provide the best quality of restored marks and the highest percentage of correctly interpreted restored marks per plate out of the six reagents tested in this study. Pearce, BJ, Dallo, I, Choi, V, Freihardt, J & Middel, CNH 2022, 'Forks in the road: Critical design moments for identifying key processes in stakeholder interaction', GAIA - Ecological Perspectives for Science and Society, vol. 31, no. 4, pp. 222-230. Pelucchi, E, Fagas, G, Aharonovich, I, Englund, D, Figueroa, E, Gong, Q, Hannes, H, Liu, J, Lu, C-Y, Matsuda, N, Pan, J-W, Schreck, F, Sciarrino, F, Silberhorn, C, Wang, J & Jöns, KD 2022, 'The potential and global outlook of integrated photonics for quantum technologies', Nature Reviews Physics, vol. 4, no. 3, pp. 194-208. Integrated quantum photonics uses classical integrated photonic technologies and devices for quantum applications. As in classical photonics, chip-scale integration has become critical for scaling up and translating laboratory demonstrators to real-life technologies. Integrated quantum photonics efforts are centred around the development of quantum photonic integrated circuits, which can be monolithically, hybrid or heterogeneously integrated. In this Roadmap, we argue, through specific examples, for the value that integrated photonics brings to quantum technologies and discuss what applications may become possible in the future by overcoming the current roadblocks. We provide an overview of the research landscape and discuss the innovation and market potential. Our aim is to stimulate further research by outlining not only the scientific challenges of materials, devices and components associated with integrated photonics for quantum technologies but also those related to the development of the necessary manufacturing infrastructure and supply chains for delivering these technologies to the market. Pendall, E, Hewitt, A, Boer, MM, Carrillo, Y, Glenn, NF, Griebel, A, Middleton, JH, Mumford, PJ, Ridgeway, P, Rymer, PD & Steenbeeke, GL 2022, 'Remarkable Resilience of Forest Structure and Biodiversity Following Fire in the Peri-Urban Bushland of Sydney, Australia', Climate, vol. 10, no. 6, pp. 86-86. Pera, JB, Davie, AW, Rohlfs, A-M & Mitrovic, SM 2022, 'Simulating the potential effects of a carp virus fish kill on water quality and phytoplankton in lentic environments', Marine and Freshwater Research, vol. 73, no. 2, pp. 178-192. Peters, KJ, Stockin, KA & Saltré, F 2022, 'On the rise: Climate change in New Zealand will cause sperm and blue whales to seek higher latitudes', Ecological Indicators, vol. 142, pp. 109235-109235. Pettersen, AK, Coleman, MA, Latombe, G, Gonzalez, SV, Williams, NLR, Seymour, JR, Campbell, AH, Thomas, T, Ferrari, R, Stuart‐Smith, RD, Edgar, GJ, Steinberg, PD & Marzinelli, EM 2022, 'Spatial compositional turnover varies with trophic level and body size in marine assemblages of micro‐ and macroorganisms', Global Ecology and Biogeography, vol. 31, no. 8, pp. 1556-1570. Pijning, AE, Butera, D & Hogg, PJ 2022, 'Not one, but many forms of thrombosis proteins', Journal of Thrombosis and Haemostasis, vol. 20, no. 2, pp. 285-292. Pinkerton, JW, Kim, RY, Brown, AC, Rae, BE, Donovan, C, Mayall, JR, Carroll, OR, Khadem Ali, M, Scott, HA, Berthon, BS, Baines, KJ, Starkey, MR, Kermani, NZ, Guo, Y-K, Robertson, AAB, O’Neill, LAJ, Adcock, IM, Cooper, MA, Gibson, PG, Wood, LG, Hansbro, PM & Horvat, JC 2022, 'Relationship between type 2 cytokine and inflammasome responses in obesity-associated asthma', Journal of Allergy and Clinical Immunology, vol. 149, no. 4, pp. 1270-1280. BACKGROUND: Obesity is a risk factor for asthma, and obese asthmatic individuals are more likely to have severe, steroid-insensitive disease. How obesity affects the pathogenesis and severity of asthma is poorly understood. Roles for increased inflammasome-mediated neutrophilic responses, type 2 immunity, and eosinophilic inflammation have been described. OBJECTIVE: We investigated how obesity affects the pathogenesis and severity of asthma and identified effective therapies for obesity-associated disease. METHODS: We assessed associations between body mass index and inflammasome responses with type 2 (T2) immune responses in the sputum of 25 subjects with asthma. Functional roles for NLR family, pyrin domain-containing (NLRP) 3 inflammasome and T2 cytokine responses in driving key features of disease were examined in experimental high-fat diet-induced obesity and asthma. RESULTS: Body mass index and inflammasome responses positively correlated with increased IL-5 and IL-13 expression as well as C-C chemokine receptor type 3 expression in the sputum of subjects with asthma. High-fat diet-induced obesity resulted in steroid-insensitive airway hyperresponsiveness in both the presence and absence of experimental asthma. High-fat diet-induced obesity was also associated with increased NLRP3 inflammasome responses and eosinophilic inflammation in airway tissue, but not lumen, in experimental asthma. Inhibition of NLRP3 inflammasome responses reduced steroid-insensitive airway hyperresponsiveness but had no effect on IL-5 or IL-13 responses in experimental asthma. Depletion of IL-5 and IL-13 reduced obesity-induced NLRP3 inflammasome responses and steroid-insensitive airway hyperresponsiveness in experimental asthma. CONCLUSION: We found a relationship between T2 cytokine and NLRP3 inflammasome responses in obesity-associated asthma, highlighting the potential utility of T2 cytokine-targeted biologics and inflammasome inhibitors. Plumanns-Pouton, E, Bennett, LT, Najera-Umaña, JC, Griebel, A & Hinko-Najera, N 2022, 'Species and Competition Interact to Influence Seasonal Stem Growth in Temperate Eucalypts', Forests, vol. 13, no. 2, pp. 224-224. Poddar, N, Scofield, J, Shi, S, Prime, EL, Kentish, SE, Qiao, GG & Martin, GJO 2022, 'Evaporation reduction and salinity control in microalgae production ponds using chemical monolayers', Algal Research, vol. 66, pp. 102783-102783. Poh, WH & Rice, SA 2022, 'Recent Developments in Nitric Oxide Donors and Delivery for Antimicrobial and Anti-Biofilm Applications', Molecules, vol. 27, no. 3, pp. 674-674. Polidori, C, Piwczynski, M, Ronchetti, F, Johnston, NP & Szpila, K 2022, 'Host-trailing satellite flight behaviour is associated with greater investment in peripheral visual sensory system in miltogrammine flies', Scientific Reports, vol. 12, no. 1, pp. 1-17. Popovic, A, Morelato, M, Baechler, S, De Grazia, A, Tahtouh, M, Roux, C & Beavis, A 2022, 'Understanding Australian methylamphetamine drug markets through relational, temporal and spatial analyses', Drug Testing and Analysis, vol. 14, no. 3, pp. 481-495. Pradhan, B, Jena, R, Talukdar, D, Mohanty, M, Sahu, BK, Raul, AK & Abdul Maulud, KN 2022, 'A New Method to Evaluate Gold Mineralisation-Potential Mapping Using Deep Learning and an Explainable Artificial Intelligence (XAI) Model', Remote Sensing, vol. 14, no. 18, pp. 4486-4486. Prasad, E, Hitchcock, C, Raymond, J, Cole, A, Barash, M, McNevin, D & van Oorschot, RAH 2022, 'Touch DNA recovery from unfired and fired cartridges: Comparison of swabbing, tape lifting and soaking', Forensic Science International, vol. 330, pp. 111101-111101. Over the recent few years, several DNA collection techniques and methodologies have been published for the recovery of DNA from fired cartridge cases. In this study, swabbing, the DNA collection technique currently used in our jurisdiction (NSW, Australia), was compared with tape lifting and soaking to assess DNA recovery rates, DNA quality and profile quality. Brass.22LR and 9mmP cartridges were used as they are the most commonly encountered in our jurisdiction. The cartridges (n = 107) were loaded into cleaned firearm magazines by three volunteers of unknown shedder status, to mimic routine casework sample types. Half of the handled cartridges were fired whilst the other half were kept unfired. STR genotypes were produced at both 29 and 30 PCR cycles to evaluate which improved handler allele detection. DNA recovery rates showed that swabbing recovered significantly less DNA than tape lifting and soaking. Whilst there were no significant differences between tape lifting and soaking, tape lifting, on average, yielded more DNA than soaking. The calibre of ammunition had no influence on DNA recovery and in line with expectations, firing was found to decrease DNA recovery for all three sampling techniques. Assessment of DNA quality showed no evidence of PCR inhibition in any of the samples for this study. However, degradation indices showed that most samples were slightly to moderately degraded. Fewer handler alleles were detected from both fired tape lifted and soaked cartridges than unfired cartridges. Whilst 30 amplification cycles allowed for the detection of slightly more handler alleles, no statistically significant differences were found between 29 and 30 PCR cycles. Nonetheless, 50% of the profiles from unfired soaked cartridges that were non-uploadable after 29 cycles were uploadable after 30 cycles. Furthermore, 83% of profiles from unfired cartridges that were tape lifted were uploadable onto our jurisdiction's database at both 29 and 30 PCR cycles. All m... Prasher, P, Sharma, M, Kumar Singh, S, Gulati, M, Kumar, D, Gupta, G, Kumar Chellappan, D, Gregory George Oliver, B, Wich, PR & Dua, K 2022, 'Versatility of acetalated dextran in nanocarriers targeting respiratory diseases', Materials Letters, vol. 323, pp. 132600-132600. Prasher, P, Sharma, M, Singh, SK, Gulati, M, Jha, NK, Gupta, PK, Gupta, G, Chellappan, DK, Zacconi, F, de Jesus Andreoli Pinto, T, Chan, Y, Liu, G, Paudel, KR, Hansbro, PM, George Oliver, BG & Dua, K 2022, 'Targeting mucus barrier in respiratory diseases by chemically modified advanced delivery systems', Chemico-Biological Interactions, vol. 365, pp. 110048-110048. Prasher, P, Sharma, M, Singh, SK, Gulati, M, Patravale, V, Oliver, BG & Dua, K 2022, 'Mucoadhesive Particles: An Emerging Toolkit for Advanced Respiratory Drug Delivery', Nanomedicine, vol. 17, no. 12, pp. 821-826. Prasher, P, Sharma, M, Singh, SK, Haghi, M, MacLoughlin, R, Chellappan, DK, Gupta, G, Paudel, KR, Hansbro, PM, George Oliver, BG, Wich, PR & Dua, K 2022, 'Advances and applications of dextran-based nanomaterials targeting inflammatory respiratory diseases', Journal of Drug Delivery Science and Technology, vol. 74, pp. 103598-103598. Price, S, Kuzhiumparambil, U, Pernice, M & Ralph, P 2022, 'Techno-economic analysis of cyanobacterial PHB bioplastic production', Journal of Environmental Chemical Engineering, vol. 10, no. 3, pp. 107502-107502. Qadir, Z, Zafar, MH, Moosavi, SKR, Le, KN & Mahmud, MAP 2022, 'Autonomous UAV Path-Planning Optimization Using Metaheuristic Approach for Predisaster Assessment', IEEE Internet of Things Journal, vol. 9, no. 14, pp. 12505-12514. Qays, MO, Ahmed, MM, Parvez Mahmud, MA, Abu‐Siada, A, Muyeen, SM, Hossain, ML, Yasmin, F & Rahman, MM 2022, 'Monitoring of renewable energy systems by IoT‐aided SCADA system', Energy Science & Engineering, vol. 10, no. 6, pp. 1874-1885. Qiao, L, Li, H, Zhong, S, Xu, X, Su, F, Peng, X, Jin, D & Zhanghao, K 2022, 'Laterally swept light-sheet microscopy enhanced by pixel reassignment for photon-efficient volumetric imaging', Advanced Photonics Nexus, vol. 2, no. 01. Quan, DH, Kwong, AJ, Hansbro, PM & Britton, WJ 2022, 'No smoke without fire: the impact of cigarette smoking on the immune control of tuberculosis', European Respiratory Review, vol. 31, no. 164, pp. 210252-210252. Quek, L-E, van Geldermalsen, M, Guan, YF, Wahi, K, Mayoh, C, Balaban, S, Pang, A, Wang, Q, Cowley, MJ, Brown, KK, Turner, N, Hoy, AJ & Holst, J 2022, 'Glutamine addiction promotes glucose oxidation in triple-negative breast cancer', Oncogene, vol. 41, no. 34, pp. 4066-4078. Quetglas-Llabrés, MM, Quispe, C, Herrera-Bravo, J, Catarino, MD, Pereira, OR, Cardoso, SM, Dua, K, Chellappan, DK, Pabreja, K, Satija, S, Mehta, M, Sureda, A, Martorell, M, Satmbekova, D, Yeskaliyeva, B, Sharifi-Rad, J, Rasool, N, Butnariu, M, Bagiu, IC, Bagiu, RV, Calina, D & Cho, WC 2022, 'Pharmacological Properties of Bergapten: Mechanistic and Therapeutic Aspects', Oxidative Medicine and Cellular Longevity, vol. 2022, pp. 1-10. Quigley, KM, Hein, M & Suggett, DJ 2022, 'Translating the 10 golden rules of reforestation for coral reef restoration', Conservation Biology, vol. 36, no. 4, pp. 1-8. Quinteros, SL, O'Brien, B & Donnelly, S 2022, 'Exploring the role of macrophages in determining the pathogenesis of liver fluke infection', Parasitology, vol. 149, no. 10, pp. 1364-1373. Quinton, AR, Kelty, SF & Scudder, N 2022, 'Attitudes towards police use of consumer/private DNA databases in investigations', Science & Justice, vol. 62, no. 3, pp. 263-271. Rad, MA, Mahmodi, H, Filipe, EC, Cox, TR, Kabakova, I & Tipper, JL 2022, 'Micromechanical characterisation of 3D bioprinted neural cell models using Brillouin microspectroscopy', Bioprinting, vol. 25, pp. e00179-e00179. Biofabrication of three-dimensional (3D) in vitro neural cell models that closely mimic the central nervous system (CNS) is an emerging field of research with applications from fundamental biology to regenerative medicine, and far reaching benefits for the economy, healthcare and the ethical use of animals. The micromechanical properties of such models are an important factor dictating the success of modelling outcomes in relation to accurate reproduction of the processes in native tissues. Characterising the micromechanical properties of such models non-destructively and over a prolonged span of time, however, are key challenges. Brillouin microspectroscopy (BM) could provide a solution to this problem since this technology is non-invasive, label-free and is capable of micro-scale 3D imaging. In this work, the micromechanical properties of 3D bioprinted neural cell models consisting of NG 108-15 neuronal cells and Gelatin methacryloyl (GelMA) hydrogels of various concentrations were investigated using BM. We demonstrate changes in the volume-averaged (VA) and local micro-scale mechanical properties of these models over a 7 day period, in which the hydrogel component of the model are found to soften as the cells grow, multiply and form stiffer spheroid-type structures. These findings signify the necessity to resolve in microscopic detail the mechanics of in vitro 3D tissue models and suggest Brillouin microspectroscopy to be a suitable technology to bridge this gap. Rädecker, N, Pogoreutz, C, Gegner, HM, Cárdenas, A, Perna, G, Geißler, L, Roth, F, Bougoure, J, Guagliardo, P, Struck, U, Wild, C, Pernice, M, Raina, J-B, Meibom, A & Voolstra, CR 2022, 'Heat stress reduces the contribution of diazotrophs to coral holobiont nitrogen cycling', The ISME Journal, vol. 16, no. 4, pp. 1110-1118. Raes, EJ, Hörstmann, C, Landry, MR, Beckley, LE, Marin, M, Thompson, P, Antoine, D, Focardi, A, O'Brien, J, Ostrowski, M & Waite, AM 2022, 'Dynamic change in an ocean desert: Microbial diversity and trophic transfer along the 110 °E meridional in the Indian Ocean', Deep Sea Research Part II: Topical Studies in Oceanography, vol. 201, pp. 105097-105097. The eastern Indian Ocean is among the most oligotrophic regions in the world and has been described as an ocean desert. Limited information exists on microbial community profiles from marker gene data, and an open question in this system is how energy is transported from the base of the food web to higher trophic levels. Here we show that, along a 3300 km long transect in the ultra-oligotrophic eastern Indian Ocean, both alpha and beta diversity metrics for prokaryotic and eukaryotic trophic groups revealed remarkably strong latitudinal trends. The latitudinal Shannon diversity pattern for autotrophic eukaryotes furthermore aligned with the isotopic δ13C ratios of particulate organic carbon, fractionated zooplankton and hand-picked fish larvae, suggesting a close trophic linkage between autotrophic eukaryotes and higher trophic levels. Our data also showed an increasing contribution of eukaryotic mixotrophs and a high contribution of heterotrophic eukaryotes towards warmer waters. These findings highlight that not only the recycling of organic matter via bacterial regeneration is important in this system but that mixo- and heterotrophic eukaryotes play a major role in redistributing energy within the marine food web of these oligotrophic waters. Our data provide a baseline to understand how environmental changes such as warming surface waters might impact the open-ocean food web in this oligotrophic basin. Rafei, R, Koong, J, Osman, M, Al Atrouni, A, Hamze, M & Hamidian, M 2022, 'Analysis of pCl107 a large plasmid carried by an ST25Acinetobacter baumanniistrain reveals a complex evolutionary history and links to multiple antibiotic resistance and metabolic pathways', FEMS Microbes, vol. 3, p. xtac027. Rahman, FH, Newaz, SHS, Au, T-W, Suhaili, WS, Mahmud, MAP & Lee, GM 2022, 'EnTruVe: ENergy and TRUst-aware Virtual Machine allocation in VEhicle fog computing for catering applications in 5G', Future Generation Computer Systems, vol. 126, pp. 196-210. It is undoubted that fog computing contributes in catering the latency-stringent applications of 5G, and one of the enabling technologies that fundamentally ensures the success of fog computing is virtualization as it offers isolation and platform independence. Although the emergence of vehicle-based fog (referred to as v-fog) facilities can certainly benefit from these desirable features of virtualization, there are several challenges that need to be addressed in order to realize the full potential that v-fogs can offer. One of the challenges of virtualization in v-fog is Virtual Machine (VM) migration. There are several factors that trigger a VM migration in a v-fog such as vehicle resource depletion. VM migrations would not only lead to nonessential usage of valuable resources (e.g. energy, bandwidth, memory) in the v-fogs, but also incur various overheads and performance degradation throughout the whole network. Thus, minimizing VM migrations is necessary. Furthermore, to ensure the seamless VM migrations between v-fogs, trust of v-fogs is required. While there exists studies of trust in the virtualization of cloud, they are irrelevant to v-fogs as v-fogs are different in nature (i.e. heterogeneous, mobile) from the cloud. Additionally, trust is not included in the decision making mechanisms of VM allocation for vehicular environments in the existing works. Moreover, as vehicle resources are constrained, their energy has to be utilized efficiently. In this paper, we propose EnTruVe, an ENergy and TRUst-aware VM allocation in VEhicle fog computing solution that aims to minimize the number of VM migrations while reducing VM processing associated energy consumption as much as possible. The VM allocation algorithm in EnTruVe provides a larger selection pool of v-fogs that meets the VMs requirements (e.g. trust, latency), thereby ensuring higher chances of success of VM allocation. Using Analytic Hierarchy Process (AHP), the proposed EnTruVe solution evaluates the... Rahman, MA, Ali, S, Phillips, MR & Ton-That, C 2022, 'Multi-wavelength emission through self-induced defects in GaZnO microrods', Journal of Alloys and Compounds, vol. 895, pp. 162693-162693. Multi-wavelength emission in wide bandgap semiconductors is commonly achieved through ternary alloying or quantum size effects. However, multi-wavelength emission within a single microstructure is highly challenging using these approaches. Here, we demonstrate that the luminescence wavelength within individual GaZnO microrods can be tailored via defect engineering. Fast chemical vapor growth of oxygen-rich ZnO microrods with Ga2O3 as an additive in the ZnO vapour leads to formation of a tapered morphology with graded distribution of Ga dopants, while the Ga incorporation does not significantly alter their crystal structure. With increasing Ga content from 1 to 6 at% from tip to base, the GaZnO microrods increase in diameter towards the substrate in accordance with the birth-and-spread mechanism. The local near-band-edge emission within single ZnO microrods, analyzed by nanoscale cathodoluminescence spectroscopy, exhibits a red shift of ~0.6 eV with increasing Ga content and exhibits signature characteristics of an excitonic emission. Density Functional Theory calculations reveal that the variation in the emission wavelength arises from bandgap narrowing due to the merging of the electronic states of Ga defect complexes with ZnO energy bands. The experimental and theoretical results demonstrate (i) the utility of using the self-regulation of defect compensation effects for band gap engineering and (ii) the possibility of multi-wavelength light sources within individual microrods. Rahman, MA, Islam, MJ, Islam, MR & Mahmud, MAP 2022, 'Correction to: Strain Dependent Performance Analysis of InGaN Multi‑junction Solar Cell', Transactions on Electrical and Electronic Materials, vol. 23, no. 1, pp. 105-105. Unfortunately, the original publication of the article was published without keywords. The keywords are given in this correction. The original article has been corrected. Rahman, MH, Mahbub, KR, Espinoza-Vergara, G, Ritchie, A, Hoque, MM, Noorian, P, Cole, L, McDougald, D & Labbate, M 2022, 'Protozoal food vacuoles enhance transformation in Vibrio cholerae through SOS-regulated DNA integration', The ISME Journal, vol. 16, no. 8, pp. 1993-2001. Raina, J-B, Lambert, BS, Parks, DH, Rinke, C, Siboni, N, Bramucci, A, Ostrowski, M, Signal, B, Lutz, A, Mendis, H, Rubino, F, Fernandez, VI, Stocker, R, Hugenholtz, P, Tyson, GW & Seymour, JR 2022, 'Chemotaxis shapes the microscale organization of the ocean’s microbiome', Nature, vol. 605, no. 7908, pp. 132-138. The capacity of planktonic marine microorganisms to actively seek out and exploit microscale chemical hotspots has been widely theorized to affect ocean-basin scale biogeochemistry1-3, but has never been examined comprehensively in situ among natural microbial communities. Here, using a field-based microfluidic platform to quantify the behavioural responses of marine bacteria and archaea, we observed significant levels of chemotaxis towards microscale hotspots of phytoplankton-derived dissolved organic matter (DOM) at a coastal field site across multiple deployments, spanning several months. Microscale metagenomics revealed that a wide diversity of marine prokaryotes, spanning 27 bacterial and 2 archaeal phyla, displayed chemotaxis towards microscale patches of DOM derived from ten globally distributed phytoplankton species. The distinct DOM composition of each phytoplankton species attracted phylogenetically and functionally discrete populations of bacteria and archaea, with 54% of chemotactic prokaryotes displaying highly specific responses to the DOM derived from only one or two phytoplankton species. Prokaryotes exhibiting chemotaxis towards phytoplankton-derived compounds were significantly enriched in the capacity to transport and metabolize specific phytoplankton-derived chemicals, and displayed enrichment in functions conducive to symbiotic relationships, including genes involved in the production of siderophores, B vitamins and growth-promoting hormones. Our findings demonstrate that the swimming behaviour of natural prokaryotic assemblages is governed by specific chemical cues, which dictate important biogeochemical transformation processes and the establishment of ecological interactions that structure the base of the marine food web. Raj, V, Gopakumar, A, Vaidya, G, Scott, J, Toth, M, Jagadish, C & Gautam, V 2022, 'High-density individually addressable platinum nanoelectrodes for biomedical applications', Discover Materials, vol. 2, no. 1. Rajala, P, Cheng, D-Q, Rice, SA & Lauro, FM 2022, 'Sulfate-dependant microbially induced corrosion of mild steel in the deep sea: a 10-year microbiome study', Microbiome, vol. 10, no. 1. Ramanunny, AK, Wadhwa, S, Gulati, M, Vishwas, S, Khursheed, R, Paudel, KR, Gupta, S, Porwal, O, Alshahrani, SM, Jha, NK, Chellappan, DK, Prasher, P, Gupta, G, Adams, J, Dua, K, Tewari, D & Singh, SK 2022, 'Journey of Alpinia galanga from kitchen spice to nutraceutical to folk medicine to nanomedicine', Journal of Ethnopharmacology, vol. 291, pp. 115144-115144. Ramanunny, AK, Wadhwa, S, Kumar Singh, S, Kumar, B, Gulati, M, Kumar, A, Almawash, S, Al Saqr, A, Gowthamarajan, K, Dua, K, Singh, H, Vishwas, S, Khursheed, R, Rahana Parveen, S, Venkatesan, A, Paudel, KR, Hansbro, PM & Kumar Chellappan, D 2022, 'Topical non-aqueous nanoemulsion of Alpinia galanga extract for effective treatment in psoriasis: In vitro and in vivo evaluation', International Journal of Pharmaceutics, vol. 624, pp. 121882-121882. Rangel Pinagé, E, M. Bell, D, Longo, M, Gao, S, Keller, M, Silva, CA, Ometto, JP, Köhler, P, Frankenberg, C & Huete, A 2022, 'Forest structure and solar-induced fluorescence across intact and degraded forests in the Amazon', Remote Sensing of Environment, vol. 274, pp. 112998-112998. Tropical forest degradation (e.g., anthropogenic disturbances such as selective logging and fires) alters forest structure and function and influences the forest's carbon sink. In this study, we explored structure-function relationships across a variety of degradation levels in the southern Brazilian Amazon by 1) investigating how forest structural properties vary as a function of degradation history using airborne lidar data; 2) assessing the effects of degradation on solar-induced chlorophyll fluorescence (SIF) seasonality using TROPOMI data; and 3) quantifying the contribution of structural variables to SIF using multiple regression models with stepwise selection of lidar metrics. Forest degradation history was obtained through Landsat time-series classification. We found that fire, logging, and time since disturbance were major determinants of forest structure, and that forests affected by fires experienced larger variability in leaf area index (LAI), canopy height and vertical structure relative to logged and intact forests. Moreover, only recently burned forests showed significantly depressed SIF during the dry season compared to intact forests. Canopy height and the vertical distribution of foliage were the best predictors of SIF. Unexpectedly, we found that wet-season SIF was higher in active regenerating forests (~ 4 years after fires or logging) compared with intact forests, despite lower LAI. Our findings help to elucidate the mechanisms of carbon accumulation in anthropogenically disturbed tropical forests and indicate that they can capture large amounts of carbon while recovering. Rasheedkhan Regina, V, Noorian, P, Sim, CBW, Constancias, F, Kaliyamoorthy, E, Booth, SC, Espinoza-Vergara, G, Rice, SA & McDougald, D 2022, 'Loss of the Acetate Switch in Vibrio vulnificus Enhances Predation Defense against Tetrahymena pyriformis', Applied and Environmental Microbiology, vol. 88, no. 2, p. AEM0166521. Ratnasari, A, Syafiuddin, A, Boopathy, R, Malik, S, Aamer Mehmood, M, Amalia, R, Dwi Prastyo, D & Syamimi Zaidi, N 2022, 'Advances in pretreatment technology for handling the palm oil mill effluent: Challenges and prospects', Bioresource Technology, vol. 344, no. Pt B, pp. 126239-126239. The palm oil mill effluent (POME) from palm milling oil activities is discharged into various water bodies which poses several environmental problems including turbidity, increases COD and BOD, adds oil and grease, increases total nitrogen, and other pollutants. Therefore, it requires effective treatment to remove the pollutants before disposal. The objective was to critically discuss the performance of POME pretreatments along with their limitations. To offer a coverage on the present less efficient technologies, the opportunities and challenges of advanced pretreatments that combine magnetic materials and natural composites as adsorbents are comprehensively reviewed here. Moreover, potential of various magnetic materials for POME pretreatment has been described. Several existing pretreatment methods such as physical pretreatments, chemical pretreatments, coagulation-flocculation, and adsorption can remove pollutant content from POME with certain limitations and the use of magnetic composite adsorbents can enhance the treatment efficiency. Ravalli, S, Roggio, F, Magrì, B, Lauretta, G, Broggi, G, Caltabiano, R, Vecchio, GM, Magro, G, Loreto, C, Castorina, A & Musumeci, G 2022, 'Immunohistochemical evaluation of autotaxin and lubricin in mild osteoarthritic rat model performing moderate physical activity', Acta Histochemica, vol. 124, no. 6, pp. 151936-151936. Raza, A, Hassan, JZ, Mahmood, A, Nabgan, W & Ikram, M 2022, 'Recent advances in membrane-enabled water desalination by 2D frameworks: Graphene and beyond', Desalination, vol. 531, pp. 115684-115684. The growing population rate and expansion of industrial sector are associated with climate variation, which steered towards global water complications. The current review summarizes the next-generation hybrid graphene-based membrane materials for water cleansing to come across global freshwater supplies. In this regard, graphene-based membrane materials are assumed as innovative materials headed for desalination route owing to their tunable functionalities as well as atomic thickness. The discussion of operating conditions and production procedures of membrane on membrane fouling and separation mechanisms are described. Furthermore, its development merits, and limitations compared to traditional polymeric membranes are also discussed. This review discusses the use of 2D materials as building blocks for membrane structures, current developments in 2D-enabled membranes, and their prospects. More devotion is required for membrane selectivity and water permeability for long-term setup at environments alike with the field for performance examination; this helps to prolong applications of graphene-based membranes materials. In this regard, we summarized the research growth on 2D materials for membrane-based water desalination for more attention. Moreover, the design strategies containing layer-layer spacing and pore size optimization to sustain the constancy of the membranes are predominantly explained. Finally, present tasks and future research directions are also offered. Razavi Bazaz, S, Mihandust, A, Salomon, R, Joushani, HAN, Li, W, A. Amiri, H, Mirakhorli, F, Zhand, S, Shrestha, J, Miansari, M, Thierry, B, Jin, D & Ebrahimi Warkiani, M 2022, 'Zigzag microchannel for rigid inertial separation and enrichment (Z-RISE) of cells and particles', Lab on a Chip, vol. 22, no. 21, pp. 4093-4109. Rehn, S, Raymond, JS, Boakes, RA & Bowen, MT 2022, 'Sucrose intake by rats affected by both intraperitoneal oxytocin administration and time of day', Psychopharmacology, vol. 239, no. 2, pp. 429-442. RATIONALE: Daily limited access to palatable food or drink at a fixed time is commonly used in rodent models of bingeing. Under these conditions, entrainment may modulate intake patterns. Oxytocin is involved in circadian patterns of intake and, when administered peripherally, reduces sucrose intake. However, oxytocin's effects on intake under limited-access conditions and its potential interaction with entrainment have not been explored. OBJECTIVES: This study examined the role of entrainment on intake patterns, oxytocin's effects on sucrose intakes and locomotor activity and whether oxytocin's effects were mediated by its actions at the oxytocin receptor. METHODS: Sated rats received daily 1-h access to 10% sucrose solution either at a fixed or varied time of day. Rats received intraperitoneal oxytocin (0 mg/kg, 0.3 mg/kg, 1 mg/kg, 3 mg/kg) prior to sucrose access, and spontaneous locomotor activity was assessed in an open-field test. Rats were then pre-treated with an oxytocin receptor antagonist, L368,899, prior to oxytocin before sucrose access. RESULTS: Intake patterns did not differ between fixed- or varied-time presentations; rats consumed more sucrose solution in the middle as opposed to the early-dark phase. Oxytocin dose-dependently reduced sucrose intakes, but also reduced locomotor activity. There was some evidence of partial blockade of oxytocin-induced sucrose intake reductions by L368,899, but the results were unclear. CONCLUSIONS: Time of day and oxytocin impact sucrose solution intake under daily limited access in rats and the sedative-like effects of oxytocin should be considered in future studies on oxytocin and food intake. Rehn, S, Raymond, JS, Boakes, RA & Bowen, MT 2022, 'Sucrose intake by rats affected by both intraperitoneal oxytocin administration and time of day', Appetite, vol. 179, pp. 106256-106256. Rehn, S, Raymond, JS, Boakes, RA & Leenaars, CHC 2022, 'A systematic review and meta-analysis of animal models of binge eating - Part 1: Definitions and food/drink intake outcomes', Neuroscience & Biobehavioral Reviews, vol. 132, pp. 1137-1156. Binge eating involves consuming excessive amounts of food within a discrete period of time and is associated with significant impairments in binge-eating disorder and bulimia nervosa. While research on clinical binge eating has provided valuable aetiological insights, animal models allow for closer examination of environmental, biological, and developmental risk factors. Numerous animal models of binge eating exist and differ widely in operational definitions of bingeing, animal characteristics and methodological parameters. The current review aimed to synthesise the available published evidence on these models. A systematic review of binge definitions in 170 articles found most studies displayed good face validity. Meta-analyses on 150 articles confirmed that the amount of food or drink consumed by animals under binge conditions was larger than that of non-binge conditions across many protocols. The meta-regression revealed species, strain, and sex moderated binge effect size, with the largest effect observed in studies with female animals and mice. Risk of bias assessment identified that improved reporting of allocation, baseline characteristics and outcome assessment is required in future studies. Reid, CJ, Cummins, ML, Börjesson, S, Brouwer, MSM, Hasman, H, Hammerum, AM, Roer, L, Hess, S, Berendonk, T, Nešporová, K, Haenni, M, Madec, J-Y, Bethe, A, Michael, GB, Schink, A-K, Schwarz, S, Dolejska, M & Djordjevic, SP 2022, 'A role for ColV plasmids in the evolution of pathogenic Escherichia coli ST58', Nature Communications, vol. 13, no. 1, p. 683. Reidy, K, Thomsen, JD, Lee, HY, Zarubin, V, Yu, Y, Wang, B, Pham, T, Periwal, P & Ross, FM 2022, 'Mechanisms of Quasi van der Waals Epitaxy of Three-Dimensional Metallic Nanoislands on Suspended Two-Dimensional Materials', Nano Letters, vol. 22, no. 14, pp. 5849-5858. Reimers, JR, Rätsep, M, Linnanto, JM & Freiberg, A 2022, 'Chlorophyll spectroscopy: conceptual basis, modern high-resolution approaches, and current challenges', Proceedings of the Estonian Academy of Sciences, vol. 71, no. 2, pp. 127-127. The conceptual formalism to understand the properties and function of chlorophylls in the gas and solution phases as well as in protein matrices is reviewed. This formalism is then applied to interpret modern high-resolution spectroscopic data, resulting from methods such as differential fluorescence line-narrowing spectroscopy and selective fluorescence excitation spectroscopy, which resolve individual vibrational transitions within the inhomogeneously broadened emission and absorption spectra of chlorophyll-a, bacteriochlorophyll-a, and pheophytin-a. Density functional theory and ab initio quantum chemical calculations are applied to interpret this data and fill in missing information needed to understand photosynthetic processes. The focus is placed on recognizing environmental and thermal effects, as well as the roles of Duschinsky rotation and non-adiabatic coupling in controlling the spectra. A critical feature of chlorophyll spectroscopy is determined to be absorption-emission asymmetry. Its ramifications for chlorophyll’s function in photosystems are expected to be significant, as most current models for understanding their function assume that absorption and emission are symmetric, i.e. in the absence of relaxation processes, molecules coherently re-emit the light that they absorbed to enact exciton transport. The effect of the Duschinsky rotation is that after vibrational excitation during the electronic transition chlorophylls mostly emit light at different energies to what they absorb, while the effect of non-adiabatic coupling is that the polarization of the light is changed. Ren, D, Leslie, LM, Huang, Y & Hu, A 2022, 'Correction of GRACE measurements of the Earth’s moment of inertia (MOI)', Climate Dynamics, vol. 58, no. 9-10, pp. 2525-2538. Ren, D, Leslie, LM, Huang, Y & Hu, A 2022, 'Correction to: Correction of GRACE measurements of the Earth’s moment of inertia (MOI)', Climate Dynamics, vol. 58, no. 9-10, pp. 2539-2539. Ren, R-J, Lu, Y-H, Jiang, Z-K, Gao, J, Zhou, W-H, Wang, Y, Jiao, Z-Q, Wang, X-W, Solntsev, AS & Jin, X-M 2022, 'Topologically protecting squeezed light on a photonic chip', Photonics Research, vol. 10, no. 2, pp. 456-456. Ren, S, Hansbro, PM, Srikusalanukul, W, Horvat, JC, Hunter, T, Brown, AC, Peel, R, Faulkner, J, Evans, T-J, Li, SC, Newby, D, Hure, A, Abhayaratna, WP, Tsimikas, S, Gonen, A, Witztum, JL, Attia, J, Ren, S, Hansbro, PM, Peel, R, Srikusalanukul, W, Abhayaratna, W, Newby, D, Hure, A, D'Este, C, Tonkin, A, Hopper, I, Thrift, A, Levi, C, Sturm, J, Durrheim, D, Hung, J, Briffa, T, Chew, D, Anderson, P, Moon, L, McEvoy, M & Attia, J 2022, 'Generation of cardio-protective antibodies after pneumococcal polysaccharide vaccine: Early results from a randomised controlled trial', Atherosclerosis, vol. 346, pp. 68-74. BACKGROUND AND AIMS: Observational studies have demonstrated that the pneumococcal polysaccharide vaccine (PPV) is associated with reduced risk of cardiovascular events. This may be mediated through IgM antibodies to OxLDL, which have previously been associated with cardioprotective effects. The Australian Study for the Prevention through Immunisation of Cardiovascular Events (AUSPICE) is a double-blind, randomised controlled trial (RCT) of PPV in preventing ischaemic events. Participants received PPV or placebo once at baseline and are being followed-up for incident fatal and non-fatal myocardial infarction or stroke over 6 years. METHODS: A subgroup of participants at one centre (Canberra; n = 1,001) were evaluated at 1 month and 2 years post immunisation for changes in surrogate markers of atherosclerosis, as pre-specified secondary outcomes: high-sensitive C-reactive protein (CRP), pulse wave velocity (PWV), and carotid intima-media thickness (CIMT). In addition, 100 participants were randomly selected in each of the intervention and control groups for measurement of anti-pneumococcal antibodies (IgG, IgG2, IgM) as well as anti-OxLDL antibodies (IgG and IgM to CuOxLDL, MDA-LDL, and PC-KLH). RESULTS: Concentrations of anti-pneumococcal IgG and IgG2 increased and remained high at 2 years in the PPV group compared to the placebo group, while IgM increased and then declined, but remained detectable, at 2 years. There were statistically significant increases in all anti-OxLDL IgM antibodies at 1 month, which were no longer detectable at 2 years; there was no increase in anti-OxLDL IgG antibodies. There were no significant changes in CRP, PWV or CIMT between the treatment groups at the 2-year follow-up. CONCLUSIONS: PPV engenders a long-lasting increase in anti-pneumococcal IgG, and to a lesser extent, IgM titres, as well as a transient increase in anti-OxLDL IgM antibodies. However, there were no detectable changes in surrogate markers of atherosclerosis... Ricafrente, A, Cwiklinski, K, Nguyen, H, Dalton, JP, Tran, N & Donnelly, S 2022, 'Stage-specific miRNAs regulate gene expression associated with growth, development and parasite-host interaction during the intra-mammalian migration of the zoonotic helminth parasite Fasciola hepatica', BMC Genomics, vol. 23, no. 1, p. 419. Ridlen, R, McGrath, K & Gorrie, CA 2022, 'Animal models of compression spinal cord injury', Journal of Neuroscience Research, vol. 100, no. 12, pp. 2201-2212. Rintoul, MS, Courtney, TA, Dohner, JL, Giddings, SN, Kekuewa, SAH, Mitarai, S, Monismith, SG, Pezner, AK & Andersson, AJ 2022, 'The Effects of Light Intensity and Flow Speed on Biogeochemical Variability Within a Fringing Coral Reef in Onna‐Son, Okinawa, Japan', Journal of Geophysical Research: Oceans, vol. 127, no. 12. Rodrigo, N, Chen, H, Pollock, CA & Glastras, SJ 2022, 'Preconception weight loss improves fertility and maternal outcomes in obese mice', Journal of Endocrinology, vol. 253, no. 1, pp. 27-38. Rodriguez-Dominguez, A, Connell, SD, Coni, EOC, Sasaki, M, Booth, DJ & Nagelkerken, I 2022, 'Phenotypic responses in fish behaviour narrow as climate ramps up', Climatic Change, vol. 171, no. 1-2, pp. 1-18. Roffel, MP, Boudewijn, IM, van Nijnatten, JLL, Faiz, A, Vermeulen, CJ, van Oosterhout, AJ, Affleck, K, Timens, W, Bracke, KR, Maes, T, Heijink, IH, Brandsma, C-A & van den Berge, M 2022, 'Identification of asthma-associated microRNAs in bronchial biopsies', European Respiratory Journal, vol. 59, no. 3, pp. 2101294-2101294. Roffey, P & Scudder, N 2022, 'Privacy implications of the new “omic” technologies in law enforcement', WIREs Forensic Science, vol. 4, no. 3. Rohilla, S, Awasthi, R, Mehta, M, Chellappan, DK, Gupta, G, Gulati, M, Singh, SK, Anand, K, Oliver, BG, Dua, K & Dureja, H 2022, 'Preparation and Evaluation of Gefitinib Containing Nanoliposomal Formulation for Lung Cancer Therapy', BioNanoScience, vol. 12, no. 1, pp. 241-255. Roper, CD, Camp, EF, Edmondson, J & Suggett, DJ 2022, 'Combined impacts of natural recruitment and active propagation for coral population recovery on the Great Barrier Reef', Marine Ecology Progress Series, vol. 700, pp. 95-109. Rose, ML, Nickels, L, Copland, D, Togher, L, Godecke, E, Meinzer, M, Rai, T, Cadilhac, DA, Kim, J, Hurley, M, Foster, A, Carragher, M, Wilcox, C, Pierce, JE & Steel, G 2022, 'Results of the COMPARE trial of Constraint-induced or Multimodality Aphasia Therapy compared with usual care in chronic post-stroke aphasia', Journal of Neurology, Neurosurgery & Psychiatry, vol. 93, no. 6, pp. 573-581. Ross, PM, Scanes, E, Poronnik, P, Coates, H & Locke, W 2022, 'Understanding STEM academics’ responses and resilience to educational reform of academic roles in higher education', International Journal of STEM Education, vol. 9, no. 1. Rourke, ML, Fowler, AM, Hughes, JM, Broadhurst, MK, DiBattista, JD, Fielder, S, Wilkes Walburn, J & Furlan, EM 2022, 'Environmental DNA (eDNA) as a tool for assessing fish biomass: A review of approaches and future considerations for resource surveys', Environmental DNA, vol. 4, no. 1, pp. 9-33. Roux, C, Bucht, R, Crispino, F, De Forest, P, Lennard, C, Margot, P, Miranda, MD, NicDaeid, N, Ribaux, O, Ross, A & Willis, S 2022, 'The Sydney declaration – Revisiting the essence of forensic science through its fundamental principles', Forensic Science International, vol. 332, pp. 111182-111182. Roy Chowdhury, P, Alhamami, T, Venter, H, Veltman, T, Carr, M, Mollinger, J, Trott, DJ & Djordjevic, SP 2022, 'Complete Genome Sequence of Pasteurella multocida Sequence Type 394, Isolated from a Case of Bovine Respiratory Disease in Australia', Microbiology Resource Announcements, vol. 11, no. 3. Royce, SG, Licciardi, PV, Beh, RC, Bourke, JE, Donovan, C, Hung, A, Khurana, I, Liang, JJ, Maxwell, S, Mazarakis, N, Pitsillou, E, Siow, YY, Snibson, KJ, Tobin, MJ, Ververis, K, Vongsvivut, J, Ziemann, M, Samuel, CS, Tang, MLK, El-Osta, A & Karagiannis, TC 2022, 'Sulforaphane prevents and reverses allergic airways disease in mice via anti-inflammatory, antioxidant, and epigenetic mechanisms', Cellular and Molecular Life Sciences, vol. 79, no. 11, p. 579. Sulforaphane has been investigated in human pathologies and preclinical models of airway diseases. To provide further mechanistic insights, we explored L-sulforaphane (LSF) in the ovalbumin (OVA)-induced chronic allergic airways murine model, with key hallmarks of asthma. Histological analysis indicated that LSF prevented or reversed OVA-induced epithelial thickening, collagen deposition, goblet cell metaplasia, and inflammation. Well-known antioxidant and anti-inflammatory mechanisms contribute to the beneficial effects of LSF. Fourier transform infrared microspectroscopy revealed altered composition of macromolecules, following OVA sensitization, which were restored by LSF. RNA sequencing in human peripheral blood mononuclear cells highlighted the anti-inflammatory signature of LSF. Findings indicated that LSF may alter gene expression via an epigenetic mechanism which involves regulation of protein acetylation status. LSF resulted in histone and α-tubulin hyperacetylation in vivo, and cellular and enzymatic assays indicated decreased expression and modest histone deacetylase (HDAC) inhibition activity, in comparison with the well-known pan-HDAC inhibitor suberoylanilide hydroxamic acid (SAHA). Molecular modeling confirmed interaction of LSF and LSF metabolites with the catalytic domain of metal-dependent HDAC enzymes. More generally, this study confirmed known mechanisms and identified potential epigenetic pathways accounting for the protective effects and provide support for the potential clinical utility of LSF in allergic airways disease. Runtsch, MC, Angiari, S, Hooftman, A, Wadhwa, R, Zhang, Y, Zheng, Y, Spina, JS, Ruzek, MC, Argiriadi, MA, McGettrick, AF, Mendez, RS, Zotta, A, Peace, CG, Walsh, A, Chirillo, R, Hams, E, Fallon, PG, Jayaraman, R, Dua, K, Brown, AC, Kim, RY, Horvat, JC, Hansbro, PM, Wang, C & O’Neill, LAJ 2022, 'Itaconate and itaconate derivatives target JAK1 to suppress alternative activation of macrophages', Cell Metabolism, vol. 34, no. 3, pp. 487-501.e8. Ruprecht, JE, King, IP, Dafforn, KA, Mitrovic, SM, Harrison, AJ, Birrer, SC, Crane, SL & Glamore, WC 2022, 'Implications of bacterial mineralisation in aquatic ecosystem response models', Water Research, vol. 209, pp. 117888-117888. Ruprecht, JE, King, IP, Mitrovic, SM, Dafforn, KA, Miller, BM, Deiber, M, Westhorpe, DP, Hitchcock, JN, Harrison, AJ & Glamore, WC 2022, 'Assessing the validity and sensitivity of microbial processes within a hydrodynamic model', Water Research, vol. 218, pp. 118445-118445. Ryan, L, Henstridge, J & Kasza, J 2022, 'The SSA is 60!', Significance, vol. 19, no. 6, pp. 34-40. Sachi Das, S, Singh, SK, Verma, PRP, Gahtori, R, Sibuh, BZ, Kesari, KK, Jha, NK, Dhanasekaran, S, Thakur, VK, Wong, LS, Djearamane, S & Gupta, PK 2022, 'Polyester nanomedicines targeting inflammatory signaling pathways for cancer therapy', Biomedicine & Pharmacotherapy, vol. 154, pp. 113654-113654. Sadraeian, M, Junior, FFP, Miranda, M, Galinskas, J, Fernandes, RS, da Cruz, EF, Fu, L, Zhang, L, Diaz, RS, Cabral-Miranda, G & Guimarães, FEG 2022, 'Study of Viral Photoinactivation by UV-C Light and Photosensitizer Using a Pseudotyped Model', Pharmaceutics, vol. 14, no. 3, pp. 683-683. Sadraeian, M, Zhang, L, Aavani, F, Biazar, E & Jin, D 2022, 'Photodynamic viral inactivation assisted by photosensitizers', Materials Today Physics, vol. 28, pp. 100882-100882. The deadly viruses, which are spreading worldwide at an alarming rate, are a major challenge for the life sciences. More efficient and cost-effective methods with fewer side effects can provide a good alternative to traditional drug-based methods. Currently, physical phenomena such as light in the form of photodynamic action are increasingly being used to inactivate viruses. Photodynamic inactivation (PDI) uses a photosensitizer (PS), light, and oxygen to generate reactive oxygen species (ROS) to inactivate microorganisms. This article reviews the use of existing PSs, as one of the essential anti-viral agents, and introduces new materials and strategies combined with PDI. Physiochemical properties of PSs and their role in interaction with virus components are discussed. Furthermore, the effectiveness of optical sensitizers with radiation methods to inactivate viruses is highlighted. Sadraeian, M, Zhang, L, Aavani, F, Biazar, E & Jin, D 2022, 'Viral inactivation by light', eLight, vol. 2, no. 1, p. 18. Saerens, G, Duong, NMH, Solntsev, AS, Karvounis, A, Dursap, T, Regreny, P, Morandi, A, Chapman, RJ, Maeder, A, Danescu, A, Penuelas, J, Chauvin, N & Grange, R 2022, 'Spontaneous Parametric Down-Conversion from GaAs Nanowires at Telecom Wavelength', EPJ Web of Conferences, vol. 266, pp. 08010-08010. Safaei, J & Wang, G 2022, 'Progress and prospects of two-dimensional materials for membrane-based osmotic power generation', Nano Research Energy, vol. 1, pp. e9120008-e9120008. Samadi, A, Sartipi, Z, Ahmad Nasrollahi, S, Sheikholeslami, B, Nassiri Kashani, M, Rouini, MR, Dinarvand, R & Firooz, A 2022, 'Efficacy assessments of tretinoin-loaded nano lipid carriers in acne vulgaris: a double blind, split-face randomized clinical study', Archives of Dermatological Research, vol. 314, no. 6, pp. 553-561. Santangelo, JS, Ness, RW, Cohan, B, Fitzpatrick, CR, Innes, SG, Koch, S, Miles, LS, Munim, S, Peres-Neto, PR, Prashad, C, Tong, AT, Aguirre, WE, Akinwole, PO, Alberti, M, Álvarez, J, Anderson, JT, Anderson, JJ, Ando, Y, Andrew, NR, Angeoletto, F, Anstett, DN, Anstett, J, Aoki-Gonçalves, F, Arietta, AZA, Arroyo, MTK, Austen, EJ, Baena-Díaz, F, Barker, CA, Baylis, HA, Beliz, JM, Benitez-Mora, A, Bickford, D, Biedebach, G, Blackburn, GS, Boehm, MMA, Bonser, SP, Bonte, D, Bragger, JR, Branquinho, C, Brans, KI, Bresciano, JC, Brom, PD, Bucharova, A, Burt, B, Cahill, JF, Campbell, KD, Carlen, EJ, Carmona, D, Castellanos, MC, Centenaro, G, Chalen, I, Chaves, JA, Chávez-Pesqueira, M, Chen, X-Y, Chilton, AM, Chomiak, KM, Cisneros-Heredia, DF, Cisse, IK, Classen, AT, Comerford, MS, Fradinger, CC, Corney, H, Crawford, AJ, Crawford, KM, Dahirel, M, David, S, De Haan, R, Deacon, NJ, Dean, C, del-Val, E, Deligiannis, EK, Denney, D, Dettlaff, MA, DiLeo, MF, Ding, Y-Y, Domínguez-López, ME, Dominoni, DM, Draud, SL, Dyson, K, Ellers, J, Espinosa, CI, Essi, L, Falahati-Anbaran, M, Falcão, JCF, Fargo, HT, Fellowes, MDE, Fitzpatrick, RM, Flaherty, LE, Flood, PJ, Flores, MF, Fornoni, J, Foster, AG, Frost, CJ, Fuentes, TL, Fulkerson, JR, Gagnon, E, Garbsch, F, Garroway, CJ, Gerstein, AC, Giasson, MM, Girdler, EB, Gkelis, S, Godsoe, W, Golemiec, AM, Golemiec, M, González-Lagos, C, Gorton, AJ, Gotanda, KM, Granath, G, Greiner, S, Griffiths, JS, Grilo, F, Gundel, PE, Hamilton, B, Hardin, JM, He, T, Heard, SB, Henriques, AF, Hernández-Poveda, M, Hetherington-Rauth, MC, Hill, SJ, Hochuli, DF, Hodgins, KA, Hood, GR, Hopkins, GR, Hovanes, KA, Howard, AR, Hubbard, SC, Ibarra-Cerdeña, CN, Iñiguez-Armijos, C, Jara-Arancio, P, Jarrett, BJM, Jeannot, M, Jiménez-Lobato, V, Johnson, M, Johnson, O, Johnson, PP, Johnson, R, Josephson, MP, Jung, MC, Just, MG, Kahilainen, A, Kailing, OS, Kariñho-Betancourt, E, Karousou, R, Kirn, LA, Kirschbaum, A, Laine, A-L, LaMontagne, JM, Lampei, C, Lara, C, Larson, EL, Lázaro-Lobo, A, Le, JH, Leandro, DS, Lee, C, Lei, Y, León, CA, Lequerica Tamara, ME, Levesque, DC, Liao, W-J, Ljubotina, M, Locke, H, Lockett, MT, Longo, TC, Lundholm, JT, MacGillavry, T, Mackin, CR, Mahmoud, AR, Manju, IA, Mariën, J, Martínez, DN, Martínez-Bartolomé, M, Meineke, EK, Mendoza-Arroyo, W, Merritt, TJS, Merritt, LEL, Migiani, G & et al. 2022, 'Global urban environmental change drives adaptation in white clover', Science, vol. 375, no. 6586, pp. 1275-1281. Saura-Múzquiz, M, Marlton, FP, Mullens, BG, Manjón-Sanz, AM, Neuefeind, JC, Everett, M, Brand, HEA, Mondal, S, Vaitheeswaran, G & Kennedy, BJ 2022, 'Understanding the Re-entrant Phase Transition in a Non-magnetic Scheelite', Journal of the American Chemical Society, vol. 144, no. 34, pp. 15612-15621. Scammell, H, Siriviboon, P, Lin, J-X, Liu, X, Liu, S, Rhodes, D, Watanabe, K, Taniguchi, T, Hone, J, Scheurer, M & Li, JIA 2022, 'A new flavor of correlation and superconductivity in small twist-angle trilayer graphene'. Scammell, HD, Ingham, J, Geier, M & Li, T 2022, 'Intrinsic first- and higher-order topological superconductivity in a doped topological insulator', Physical Review B, vol. 105, no. 19, p. 195149. We explore higher-order topological superconductivity in an artificial Dirac material with intrinsic spin-orbit coupling, which is a doped Z2 topological insulator in the normal state. A mechanism for superconductivity due to repulsive interactions, pseudospin pairing, has recently been shown to naturally result in higher-order topology in Dirac systems past a minimum chemical potential [T. Li et al., 2D Mater. 9, 015031 (2022)2053-158310.1088/2053-1583/ac4060]. Here we apply this theory through microscopic modeling of a superlattice potential imposed on an inversion-symmetric hole-doped semiconductor heterostructure, known as hole-based semiconductor artificial graphene, and extend previous work to include the effects of spin-orbit coupling. We find that spin-orbit coupling enhances interaction effects, providing an experimental handle to increase the efficiency of the superconducting mechanism. We show that the phase diagram of these systems, as a function of chemical potential and interaction strength, contains three superconducting states: a first-order topological p+ip state, a second-order topological spatially modulated p+iτp state, and a second-order topological extended s-wave state sτ. We calculate the symmetry-based indicators for the p+iτp and sτ states, which prove these states possess second-order topology. Exact diagonalization results are presented which illustrate the interplay between the boundary physics and spin-orbit interaction. We argue that this class of systems offers an experimental platform to engineer and explore first- and higher-order topological superconducting states. Scammell, HD, Li, JIA & Scheurer, MS 2022, 'Theory of zero-field superconducting diode effect in twisted trilayer graphene', 2D Materials, vol. 9, no. 2, pp. 025027-025027. Schell, KR, Fernandes, KE, Shanahan, E, Wilson, I, Blair, SE, Carter, DA & Cokcetin, NN 2022, 'The Potential of Honey as a Prebiotic Food to Re-engineer the Gut Microbiome Toward a Healthy State', Frontiers in Nutrition, vol. 9, pp. 1-10. Scott, JA, Bishop, J & Toth, M 2022, 'Suppression of Surface Roughening during Ion Bombardment of Semiconductors', Chemistry of Materials, vol. 34, no. 19, pp. 8968-8974. Ion beams are used routinely for processing of semiconductors, particularly sputtering, ion implantation, and direct-write fabrication of nanostructures. However, the utility of ion beam techniques is limited by crystal damage and surface roughening. Damage can be reduced or eliminated by performing irradiation at elevated temperatures. However, under these conditions, surface roughening is highly problematic due to thermal mobility of adatoms and surface vacancies. Here, we solve this problem using hydrogen gas, which we use to stabilize surface mass flow and suppress roughening during ion bombardment of elemental and compound semiconductors. We achieve smooth surfaces during ion beam processing and show that the method can be enhanced by radicalizing H2gas using a remote plasma source. Our approach is broadly applicable and expands the utility of ion beam techniques for the processing and fabrication of functional materials and nanostructures. Senanayake, S, Pradhan, B, Huete, A & Brennan, J 2022, 'Spatial modeling of soil erosion hazards and crop diversity change with rainfall variation in the Central Highlands of Sri Lanka', Science of The Total Environment, vol. 806, no. Pt 2, pp. 150405-150405. The spatial variation of soil erosion is essential for farming system management and resilience development, specifically in the high climate hazard vulnerable tropical countries like Sri Lanka. This study aimed to investigate climate and human-induced soil erosion through spatial modeling. Remote sensing was used for spatial modeling to detect soil erosion, crop diversity, and rainfall variation. The study employed a time-series analysis of several variables such as rainfall, land-use land-cover (LULC) and crop diversity to detect the spatial variability of soil erosion in farming systems. Rain-use efficiency (RUE) and residual trend analysis (RESTREND) combined with a regression approach were applied to partition the soil erosion due to human and climate-induced land degradation. Results showed that soil erosion has increased from 9.08 Mg/ha/yr to 11.08 Mg/ha/yr from 2000 to 2019 in the Central Highlands of Sri Lanka. The average annual rainfall has increased in the western part of the Central Highlands, and soil erosion hazards such as landslides incidence also increased during this period. However, crop diversity has been decreasing in farming systems, namely wet zone low country (WL1a) and wet zone mid-country (WM1a), in the western part of the Central Highlands. The RUE and RESTREND analyses reveal climate-induced soil erosion is responsible for land degradation in these farming systems and is a threat to sustainable food production in the farming systems of the Central Highlands. Shabbir, B, Liu, J, Krishnamurthi, V, Ayyubi, RAW, Tran, K, Tawfik, SA, Hossain, MM, Khan, H, Wu, Y, Shivananju, BN, Sagar, RUR, Mahmood, A, Younis, A, Uddin, MH, Bukhari, SA, Walia, S, Li, Y, Spencer, MJS, Mahmood, N & Jasieniak, JJ 2022, 'Soft X‐ray Detectors Based on SnS Nanosheets for the Water Window Region', Advanced Functional Materials, vol. 32, no. 3, pp. 2105038-2105038. Shad, KF, Soubra, W & Cordato, DJ 2022, 'The Auditory Afferent Pathway as a Clinical Marker of Alzheimer’s Disease', Journal of Alzheimer's Disease, vol. 85, no. 1, pp. 47-53. Shahid, A, Siddiqui, AJ, Musharraf, SG, Liu, C-G, Malik, S, Syafiuddin, A, Boopathy, R, Tarbiah, NI, Gull, M & Mehmood, MA 2022, 'Untargeted metabolomics of the alkaliphilic cyanobacterium Plectonema terebrans elucidated novel stress-responsive metabolic modulations', Journal of Proteomics, vol. 252, pp. 104447-104447. Alkaliphilic cyanobacteria are suitable candidates to study the effect of alkaline wastewater cultivation on molecular metabolic responses. In the present study, the impact of wastewater, alkalinity, and alkaline wastewater cultivation was studied on the biomass production, biochemical composition, and the alkalinity responsive molecular mechanism through metabolomics. The results suggested a 1.29 to 1.44-fold higher biomass production along with improved lipid, carbohydrate, and pigment production under alkaline wastewater cultivation. The metabolomics analysis showed 1.2-fold and 5.54-fold increase in the indole-acetic acid and phytoene biosynthesis which contributed to overall enhanced cell differentiation and photo-protectiveness. Furthermore, lower levels of Ribulose-1,5-bisphosphate (RuBP), and higher levels of 2-phosphoglycerate and 3-phosphoglycerate suggested the efficient fixation of CO2 into biomass, and storage compounds including polysaccharides, lipids, and sterols. Interestingly, except L-histidine and L-phenylalanine, all the metabolites related to protein biosynthesis were downregulated in response to wastewater and alkaline wastewater cultivation. The cells protected themselves from alkalinity and nutrient stress by improving the biosynthesis of sterols, non-toxic antioxidants, and osmo-protectants. Alkaline wastewater cultivation regulated the activation of carbon concentration mechanism (CCM), glycolysis, fatty-acid biosynthesis, and shikimate pathway. The data revealed the importance of alkaline wastewater cultivation for improved CO2 fixation, wastewater treatment, and producing valuable bioproducts including phytoene, Lyso PC 18:0, and sterols. These metabolic pathways could be future targets of metabolic engineering for improving biomass and metabolite production. SIGNIFICANCE: Alkalinity is an imperative factor, responsible for the contamination control and biochemical regulation in cyanobactera, especially during the wastewater cultivati... Shahrokhi, S, Dubajic, M, Dai, Z, Bhattacharyya, S, Mole, RA, Rule, KC, Bhadbhade, M, Tian, R, Mussakhanuly, N, Guan, X, Yin, Y, Nielsen, MP, Hu, L, Lin, C, Chang, SLY, Wang, D, Kabakova, IV, Conibeer, G, Bremner, S, Li, X, Cazorla, C & Wu, T 2022, 'Anomalous Structural Evolution and Glassy Lattice in Mixed‐Halide Hybrid Perovskites', Small, vol. 18, no. 21, pp. e2200847-2200847. Sharif, HMA, Ali, M, Mahmood, A, Asif, MB, Din, MAU, Sillanpää, M, Mahmood, A & Yang, B 2022, 'Separation of Fe from wastewater and its use for NOx reduction; a sustainable approach for environmental remediation', Chemosphere, vol. 303, no. Pt 2, pp. 135103-135103. The nitrogen and sulphur oxide (NOx and SO2) emissions are causing a serious threat to the existence of life on earth, requiring their effective removal for a sustainable future. Among various approaches, catalytic or electrochemical reduction of air pollutants (NOx) has gained much attention due to its high efficiency and the possibility of converting these gases into valuable products. However, the required catalysts are generally synthesized from lab-grade chemicals, which may not be a sustainable approach. Herein, a sustainable approach is presented to synthesize an efficient iron-based catalyst directly from industrial/lake wastewater (WW) for NOx-reduction. According to the theoretical calculations and experimental results, Fe-ions could be readily recovered from wastewater because it has the best adsorption efficiency among all other co-existing metals (Ni2+, Cd2+, Co2+, Cu2+, and Cr6+). The subsequent experimental investigations confirmed the preferential Fe adsorption from different WW streams to develop Fe3O4@EDTA-Fe composite, whereby Fe3O4 could be used due to its high recycling ability, and ethylenediaminetetraacetic acid (EDTA) acted as a chelating agent to adsorb Fe-metal from effluents. The Fe3O4@EDTA-Fe exhibited high efficiency (≥87%) for NOx reduction even in the presence of high-degree oxygen contents (10-12%). Moreover, Fe3O4-EDTA-Fe showed excellent long-term stability for 24 h and maintained more than 80% NOx reduction. The fabricated catalyst has a great potential for executing a dual role simultaneously for Fe-recovery and NOx removal, promoting the circular economy concept and providing a potentially sustainable remediation approach for large-scale applications. Sharma, B, Kumar, S, Preeti, Johansen, MD, Kremer, L & Kumar, V 2022, '1H‐1,2,3‐triazole embedded Isatin‐Benzaldehyde‐bis(heteronuclearhydrazones): design, synthesis, antimycobacterial, and cytotoxic evaluation', Chemical Biology & Drug Design, vol. 99, no. 2, pp. 301-307. Sharma, N, Kulkarni, GT, Bhatt, AN, Satija, S, Singh, L, Sharma, A, Dua, K, Karwasra, R, Khan, AA, Ahmad, N & Raza, K 2022, 'Therapeutic Options for the SARS-CoV-2 Virus: Is There a Key in Herbal Medicine?', Natural Product Communications, vol. 17, no. 9, pp. 1934578X2211263-1934578X2211263. Sharma, P, Dhanjal, DS, Chopra, C, Tambuwala, MM, Sohal, SS, van der Spek, PJ, Sharma, HS & Satija, S 2022, 'Targeting eosinophils in chronic respiratory diseases using nanotechnology-based drug delivery', Chemico-Biological Interactions, vol. 365, pp. 110050-110050. Sheldon, F, Barma, D, Baumgartner, LJ, Bond, N, Mitrovic, SM & Vertessy, R 2022, 'Assessment of the causes and solutions to the significant 2018–19 fish deaths in the Lower Darling River, New South Wales, Australia', Marine and Freshwater Research, vol. 73, no. 2, pp. 147-158. Sherrell, PC, Fronzi, M, Shepelin, NA, Corletto, A, Winkler, DA, Ford, M, Shapter, JG & Ellis, AV 2022, 'A bright future for engineering piezoelectric 2D crystals', Chemical Society Reviews, vol. 51, no. 2, pp. 650-671. Shi, H, Rath, EM, Lin, RCY, Sarun, KH, Clarke, CJ, McCaughan, BC, Ke, H, Linton, A, Lee, K, Klebe, S, Maitz, J, Song, K, Wang, Y, Kao, S & Cheng, YY 2022, '3-Dimensional mesothelioma spheroids provide closer to natural pathophysiological tumor microenvironment for drug response studies', Frontiers in Oncology, vol. 12, pp. 1-12. Shi, H, Tsai, KH, Ma, D, Wang, X, Desai, R, Parungao, RJ, Hunt, NJ, Cheng, YY, Zhang, H, Xu, Y, Simanainen, U, Tan, Q, Cooper, MS, Handelsman, DJ, Maitz, PK & Wang, Y 2022, 'Controlled dual release of dihydrotestosterone and flutamide from polycaprolactone electrospun scaffolds accelerate burn wound healing', The FASEB Journal, vol. 36, no. 5, p. e22310. Wound healing is a complex process involving multiple independent and overlapping sequential physiological mechanisms. In addition to cutaneous injury, a severe burn stimulates physiological derangements that induce a systemic hypermetabolic response resulting in impaired wound healing. Topical application of the anti-androgen drug, flutamide accelerates cutaneous wound healing, whereas paradoxically systemic dihydrotestosterone (DHT) improves burn wound healing. We developed and characterized a PCL scaffold that is capable of controlled release of androgen (DHT) and anti-androgen (F) individually or together. This study aims to investigate whether local modification of androgen actions has an impact on burn injury wound healing. In a full-thickness burn wound healing, mouse model, DHT/F-scaffold showed a significantly faster wound healing compared with F-scaffold or DHT-scaffold. Histology analysis confirmed that DHT/F-scaffold exhibited higher re-epithelization, cell proliferation, angiogenesis, and collagen deposition. Dual release of DHT and F from PCL scaffolds promoted cell proliferation of human keratinocytes and alters the keratinocyte cell cycle. Lastly, no adverse effects on androgen-dependent organs, spleen and liver were observed. In conclusion, we demonstrated DHT plus F load PCL scaffolds accelerated burn wound healing when loading alone did not. These findings point to a complex role of androgens in burn wound healing and open novel therapeutic avenues for treating severe burn patients. Shi, Y, Wu, Y, Chin, LK, Li, Z, Liu, J, Chen, MK, Wang, S, Zhang, Y, Liu, PY, Zhou, X, Cai, H, Jin, W, Yu, Y, Yu, R, Huang, W, Yap, PH, Xiao, L, Ser, W, Nguyen, TTB, Lin, Y, Wu, PC, Liao, J, Wang, F, Chan, CT, Kivshar, Y, Tsai, DP & Liu, AQ 2022, 'Multifunctional Virus Manipulation with Large‐Scale Arrays of All‐Dielectric Resonant Nanocavities', Laser & Photonics Reviews, vol. 16, no. 5, pp. 2100197-2100197. Shi, Y-L, Huang, D, Ling, FC-C, Tian, Q-S, Liao, L-S, Phillips, MR & Ton-That, C 2022, 'Correlation between small polaron tunneling relaxation and donor ionization in Ga2O3', Applied Physics Letters, vol. 120, no. 17, pp. 172105-172105. Shilling, PJ, Khananisho, D, Cumming, AJ, Söderström, B & Daley, DO 2022, 'Signal amplification of araC pBAD using a standardized translation initiation region', Synthetic Biology, vol. 7, no. 1, p. ysac009. Shirazi, RS, Vyssotski, M, Lagutin, K, Thompson, D, MacDonald, C, Luscombe, V, Glass, M, Parker, K, Gowing, EK, Williams, DBG & Clarkson, AN 2022, 'Neuroprotective activity of new Shon, IH, Kumar, D, Schreuder, M, Guille, J, Doan, J, Sathikumar, C, Van, K, Chicco, A & Hogg, PJ 2022, 'Preclinical Assessment of [68Ga]Ga-Cell Death Indicator (CDI): A Novelhsp90 Ligand for Positron Emission Tomography of Cell Death', Current Radiopharmaceuticals, vol. 15, no. 3, pp. 184-193. Shrestha, J, Razavi Bazaz, S, Ding, L, Vasilescu, S, Idrees, S, Söderström, B, Hansbro, PM, Ghadiri, M & Ebrahimi Warkiani, M 2022, 'Rapid separation of bacteria from primary nasal samples using inertial microfluidics', Lab on a Chip, vol. 23, no. 1, pp. 146-156. Shukla, MK, Dubey, A, Pandey, S, Singh, SK, Gupta, G, Prasher, P, Chellappan, DK, Oliver, BG, Kumar, D & Dua, K 2022, 'Managing Apoptosis in Lung Diseases using Nano-assisted Drug Delivery System', Current Pharmaceutical Design, vol. 28, no. 39, pp. 3202-3211. Shukla, SD, Shastri, MD, Vanka, SK, Jha, NK, Dureja, H, Gupta, G, Chellappan, DK, Oliver, BG, Dua, K & Walters, EH 2022, 'Correction to: Targeting intercellular adhesion molecule-1 (ICAM-1) to reduce rhinovirus-induced acute exacerbations in chronic respiratory diseases', Inflammopharmacology, vol. 30, no. 4, pp. 1477-1477. Shukla, SD, Shastri, MD, Vanka, SK, Jha, NK, Dureja, H, Gupta, G, Chellappan, DK, Oliver, BG, Dua, K & Walters, EH 2022, 'Targeting intercellular adhesion molecule-1 (ICAM-1) to reduce rhinovirus-induced acute exacerbations in chronic respiratory diseases', Inflammopharmacology, vol. 30, no. 3, pp. 725-735. Shute, RH, Didaskalou, E & Dedousis-Wallace, A 2022, 'Does emotional intelligence play a role in teachers' likelihood of intervening in students' indirect bullying? A preliminary study', Teaching and Teacher Education, vol. 119, pp. 103851-103851. Sillapachaiyaporn, C, Chuchawankul, S, Nilkhet, S, Moungkote, N, Sarachana, T, Ung, AT, Baek, SJ & Tencomnao, T 2022, 'Ergosterol isolated from cloud ear mushroom (Auricularia polytricha) attenuates bisphenol A-induced BV2 microglial cell inflammation', Food Research International, vol. 157, pp. 111433-111433. Sim, JXF, Doolette, CL, Vasileiadis, S, Drigo, B, Wyrsch, ER, Djordjevic, SP, Donner, E, Karpouzas, DG & Lombi, E 2022, 'Pesticide effects on nitrogen cycle related microbial functions and community composition', Science of The Total Environment, vol. 807, pp. 150734-150734. Sintov, E, Nikolskiy, I, Barrera, V, Hyoje-Ryu Kenty, J, Atkin, AS, Gerace, D, Ho Sui, SJ, Boulanger, K & Melton, DA 2022, 'Whole-genome CRISPR screening identifies genetic manipulations to reduce immune rejection of stem cell-derived islets', Stem Cell Reports, vol. 17, no. 9, pp. 1976-1990. Slobozhanyuk, AP, Shchelokova, AV, Dobrykh, DA, Seregin, PS, Powell, DA, Shadrivov, IV, Webb, AG, Belov, PA & Lapine, M 2022, 'Detunable Wire Metasurface for Applications in Magnetic Resonance Imaging', Bulletin of the Russian Academy of Sciences: Physics, vol. 86, no. S1, pp. S216-S221. Smit, R, Awadallah, M, Bagheri, S & Surawski, NC 2022, 'Real-world emission factors for SUVs using on-board emission testing and geo-computation', Transportation Research Part D: Transport and Environment, vol. 107, pp. 103286-103286. A Portable Emissions Measurement System (PEMS) was used to measure emissions of five sports utility vehicles (SUVs) in a wide range of real-world driving conditions. The program included testing of fuel quality, coast-down and emissions in start, hot running and extended idling conditions. Geo-computation methods were used to add critical information (road gradient) to the PEMS data. Results from this study are generally in good agreement with international PEMS data. Hot running NOx emission factors are on average seven times higher than the type-approval limit for diesel SUVs, and they reach about 2100 and 400 mg/km in urban conditions for NOx and NO2, respectively. They are 7 (NOx) and 4 (NO2) times higher than current emission factors in COPERT Australia. COPERT Australia emission algorithms for CO2 are well behaved and the PEMS data suggest an update is not required. COPERT Australia emission algorithms should be revised for diesel SUVs (NOx, NO2) and petrol SUVs (CO, THC, NO2) to ensure accurate estimation of vehicle emissions at fleet level. Inclusion of logistic regression is proposed for future COPERT updates. Smith, GB, Gentle, AR & Arnold, MD 2022, 'Partial coherence and amplified internal energy when thermal radiation is sourced within matter', Journal of Physics Communications, vol. 6, no. 6, pp. 065004-065004. Smith, P, Beaumont, L, Bernacchi, CJ, Byrne, M, Cheung, W, Conant, RT, Cotrufo, F, Feng, X, Janssens, I, Jones, H, Kirschbaum, MUF, Kobayashi, K, LaRoche, J, Luo, Y, McKechnie, A, Penuelas, J, Piao, S, Robinson, S, Sage, RF, Sugget, DJ, Thackeray, SJ, Way, D & Long, SP 2022, 'Essential outcomes for COP26', Global Change Biology, vol. 28, no. 1, pp. 1-3. Söderström, B, Pittorino, MJ, Daley, DO & Duggin, IG 2022, 'Assembly dynamics of FtsZ and DamX during infection-related filamentation and division in uropathogenic E. coli', Nature Communications, vol. 13, no. 1, p. 3648. Solntsev, AS, Batalov, SV, Langford, NK & Sukhorukov, AA 2022, 'Complete conversion between one and two photons in nonlinear waveguides: theory of dispersion engineering', New Journal of Physics, vol. 24, no. 6, pp. 065002-065002. Song, A, Tian, H, Yang, W, Yang, W, Xie, Y, Liu, H, Wang, G & Shao, G 2022, 'Enhanced confinement synthesis of atomically dispersed Fe-N-C catalyst from resin polymer for oxygen reduction', Journal of Energy Chemistry, vol. 65, pp. 630-636. Due to larger atom utilization, unique electronic properties and unsaturated coordination, atomically dispersed non-precious metal catalysts with outstanding performances have received great attention in electrocatalysis. Considering the challenge of serious aggregation, rational synthesis of an atomic catalyst with good dispersion of atoms is paramount to the development of these catalysts. Herein, we report an enhanced confinement strategy to synthesize a catalyst comprised of atomically dispersed Fe supported on porous nitrogen-doped graphitic carbon from the novel and more cross-linkable Melamine-Glyoxal Resin. Densified isolated grid trapping, excessive melamine restricting, and nitrogen anchoring are strongly combined to ensure the final atomic-level dispersion of metal atoms. Experimental studies revealed enhanced kinetics of the obtained catalyst towards oxygen reduction reaction (ORR). This catalytic activity originates from the highly active surface with atomically dispersed iron sites as well as the multi-level three-dimensional structure with fast mass and electron transfer. The enhanced confinement strategy endows the resin-derived atomic catalyst with a great prospect to develop for commercialization in future. Song, M-S, Li, RW, Qiu, Y, Man, SM, Tuipulotu, DE, Birbilis, N, Smith, PN, Cole, I, Kaplan, DL & Chen, X-B 2022, 'Gallium–Strontium Phosphate Conversion Coatings for Promoting Infection Prevention and Biocompatibility of Magnesium for Orthopedic Applications', ACS Biomaterials Science & Engineering, vol. 8, no. 6, pp. 2709-2723. Speer, M, Hartigan, J & Leslie, L 2022, 'Machine Learning Assessment of the Impact of Global Warming on the Climate Drivers of Water Supply to Australia’s Northern Murray-Darling Basin', Water, vol. 14, no. 19, pp. 3073-3073. Speer, MS, Leslie, LM & Hartigan, J 2022, 'Jet Stream Changes over Southeast Australia during the Early Cool Season in Response to Accelerated Global Warming', Climate, vol. 10, no. 6, pp. 84-84. Spennati, E, Casazza, AA, Converti, A, Padula, MP, Dehghani, F, Perego, P & Valtchev, P 2022, 'Winery waste valorisation as microalgae culture medium: A step forward for food circular economy', Separation and Purification Technology, vol. 293, pp. 121088-121088. Wastewater is one of the critical environmental problems worldwide. In this study, the circular economy concept was applied to winery wastewater that has been considered as a rich source of nutrients for growing edible microalgae to produce a high value protein product. To this end, Chlorella vulgaris and Arthrospira platensis were co-cultured. The effects of processing parameters on the microalgae yield and protein recovery were examined. Different microalgae growth systems: open pond, column and tubular photobioreactor were used for obtaining more than two grams of dry weight biomass per liter. The protein fraction was extracted and recovered by ultrasound-assisted extraction. The image analysis shows that wastewater strongly affected the intracellular components concentration, cell morphology, and resistivity to cell rupture. The results of our study demonstrate that it is viable to use microalgae to substantially reduce the pollutant impact of the wastewater and produce high value products such as proteins. Srivastava, A, Yetemen, O, Saco, PM, Rodriguez, JF, Kumari, N & Chun, KP 2022, 'Influence of orographic precipitation on coevolving landforms and vegetation in semi‐arid ecosystems', Earth Surface Processes and Landforms, vol. 47, no. 12, pp. 2846-2862. Steele, JR, Italiano, CJ, Phillips, CR, Violi, JP, Pu, L, Rodgers, KJ & Padula, MP 2022, 'Correction: Steele et al. Misincorporation Proteomics Technologies: A Review. Proteomes 2021, 9, 2', Proteomes, vol. 10, no. 2, pp. 22-22. Steiner, R, Roux, C & Moret, S 2022, 'Production of artificial fingermarks. Part I – Synthetic secretions formulation', Forensic Science International, vol. 331, pp. 111166-111166. Fingermark variability is a critical parameter. To mitigate the effects of this variability, synthetic secretions in the form of simple mixtures of target compounds found in eccrine sweat have been described in the literature, but they are usually reactive towards only a minimal range of detection techniques. If this approach is acceptable for the production of single-technique test strips, such artificial secretions cannot be considered as reliable fingermark simulants because they do not reproduce the complex matrix that makes up real secretions. Research has shown that sebaceous and eccrine compounds are probably present simultaneously in fingermark residue in the form of an emulsion. This paper is the first part of a research project that aims at producing realistic artificial fingermarks containing an extensive range of eccrine and sebaceous compounds. This first study aimed to reproduce and compare two synthetic fingermark residues formulations and assess their potential to be used as fingermark simulants. Spot tests of the artificial secretions were deposited on paper substrates, and their reactivity with four common detection techniques was tested: 1,2-indanedione-zinc, ninhydrin, oil red O, and physical developer. Both formulations showed very good results when processed with the two amino acid reagents, as well as oil red O, and no obvious differences were observed between the two versions. The results obtained with the physical developer were inconsistent and demonstrated that the fundamental working principle of physical developer needs to be further understood. The results were extremely promising as they showed the potential of such reproducible artificial secretions to be used to assess an extensive range of detection techniques, which would be highly beneficial to guarantee better research and quality control in fingermark detection. The use of spot tests to deposit the simulant was shown to be unreliable and a more controllable and repr... Stella, CJ, Meakin, GE & van Oorschot, RAH 2022, 'DNA transfer in packaging: Attention required', Forensic Science International: Genetics Supplement Series, vol. 8, pp. 303-305. Stern, HL, Gu, Q, Jarman, J, Eizagirre Barker, S, Mendelson, N, Chugh, D, Schott, S, Tan, HH, Sirringhaus, H, Aharonovich, I & Atatüre, M 2022, 'Room-temperature optically detected magnetic resonance of single defects in hexagonal boron nitride', Nature Communications, vol. 13, no. 1, pp. 1-9. Stewart, EL, Counoupas, C, Johansen, MD, Nguyen, DH, Miemczyk, S, Hansbro, NG, Ferrell, KC, Ashhurst, A, Alca, S, Ashley, C, Steain, M, Britton, WJ, Hansbro, PM, Petrovsky, N & Triccas, JA 2022, 'Mucosal immunization with a delta-inulin adjuvanted recombinant spike vaccine elicits lung-resident immune memory and protects mice against SARS-CoV-2', Mucosal Immunology, vol. 15, no. 6, pp. 1405-1415. Multiple SARS-CoV-2 vaccine candidates have been approved for use and have had a major impact on the COVID-19 pandemic. There remains, however, a significant need for vaccines that are safe, easily transportable and protective against infection, as well as disease. Mucosal vaccination is favored for its ability to induce immune memory at the site of infection, making it appealing for SARS-CoV-2 vaccine strategies. In this study we performed in-depth analysis of the immune responses in mice to a subunit recombinant spike protein vaccine formulated with the delta-inulin adjuvant Advax when administered intratracheally (IT), versus intramuscular delivery (IM). Both routes produced robust neutralizing antibody titers (NAb) and generated sterilizing immunity against SARS-CoV-2. IT delivery, however, produced significantly higher systemic and lung-local NAb that resisted waning up to six months post vaccination, and only IT delivery generated inducible bronchus-associated lymphoid tissue (iBALT), a site of lymphocyte antigen presentation and proliferation. This was coupled with robust and long-lasting lung tissue-resident memory CD4+ and CD8+ T cells that were not observed in IM-vaccinated mice. This study provides a detailed view of the lung-resident cellular response to IT vaccination against SARS-CoV-2 and demonstrates the importance of delivery site selection in the development of vaccine candidates. Stewart, J, Fowler, AM, Meadows, NM & Johnson, DD 2022, 'Life-history traits and commercial catch composition of Chelidonichthys kumu in south-eastern Australia', Regional Studies in Marine Science, vol. 56, pp. 102720-102720. Stothard, JR & Ellis, JT 2022, 'Updates on Parasitology and adopting a Gold Open Access model of production', Parasitology, vol. 149, no. 12, pp. 1523-1525. Strudwick, P, Seymour, J, Camp, EF, Edmondson, J, Haydon, T, Howlett, L, Le Reun, N, Siboni, N & Suggett, DJ 2022, 'Correction to: Impacts of nursery-based propagation and out-planting on coral-associated bacterial communities', Coral Reefs, vol. 41, no. 2, pp. 473-473. Stuart, J, Smith, KF, Rhodes, L, Murray, JS, Viallon, J, Henry, K, Darius, HT, Murray, SA, De Azevedo, CD, Argyle, P & Chinain, M 2022, 'Geographical distribution, molecular and toxin diversity of the dinoflagellate species Gambierdiscus honu in the Pacific region', Harmful Algae, vol. 118, pp. 102308-102308. An increase in cases of ciguatera poisoning (CP) and expansion of the causative species in the South Pacific region highlight the need for baseline data on toxic microalgal species to help identify new areas of risk and manage known hot spots. Gambierdiscus honu is a toxin producing and potential CP causing dinoflagellate species, first described in 2017. Currently no high-resolution geographical distribution, intraspecific genetic variation or toxin production diversity data is available for G. honu. This research aimed to further characterize G. honu by investigating its distribution using species-specific real-time polymerase chain reaction assays at 25 sites in an area spanning ∼8000 km of the Coral Sea/Pacific Ocean, and assessing intraspecific genetic variation, toxicity and toxin production of isolated strains. Assessment of genetic variation of the partial rRNA operon of isolates demonstrated no significant intraspecific population structure, in addition to a lack of adherence to isolation by distance (IBD) model of evolution. The detected distribution of G. honu in the Pacific region was within the expected tropical to temperate latitudinal ranges of 10° to -30° and extended from Australia to French Polynesia. In the lipophilic fractions, the neuroblastoma cell-based assay (CBA-N2a) showed no ciguatoxin (CTX)-like activity for nine of the 10 isolates, and an atypical pattern for CAWD233 isolate which showed cytotoxic activity in OV- and OV+ conditions. In the same way, liquid chromatography-tandem mass spectrometry (LC-MS/MS) analysis confirmed no Pacific-CTXs (CTX-3B, CTX-3C, CTX-4A, CTX-4B) were produced by the ten strains. The CBA-N2a assessment of the hydrophilic fractions showed moderate to high cytotoxicity in both OV- and OV+ condition for all the strains showing a cytotoxic profile similar to that of gambierone. Indeed, this study is the first to show the cytotoxic activity of gambierone on mouse neuroblastoma cells while no cytotoxicit... Su, F, Luo, X, Du, Z, Chen, Z, Liu, Y, Jin, X, Guo, Z, Lu, J & Jin, D 2022, 'High-Contrast Luminescent Immunohistochemistry Using PEGylated Lanthanide Complexes', Analytical Chemistry, vol. 94, no. 50, pp. 17587-17594. Immunohistochemistry (IHC) using fluorescent probes provides high resolution with multiplexing capability, but the imaging contrast is limited by the brightness of the fluorescent probe and the intrinsic autofluorescence background from tissues. Herein, we improved the contrast by high-density labeling of long-lifetime lanthanide complexes and time-gated imaging. As the large (∼280 nm) Stokes shift of lanthanide complexes effectively prevents the issue of concentration quenching, we succeeded in conjugating seven europium complexes to an eight-arm hydrophilic poly(ethylene glycol) (PEG) linker for signal amplification with improved water solubility to the level of up to 10 mg/mL. Moreover, we demonstrated that both human epidermal growth factor receptor 2 (HER2) in a formalin-fixed paraffin-embedded (FFPE) tissue section and cytokeratin 18 (CK18) in a frozen section can be resolved with the enhanced contrast by 2-fold and 3-fold, respectively. Furthermore, we show that the PEGylation of multiple lanthanide complexes is compatible with tyramide signal amplification (TSA). This work suggests new opportunities for sensitive imaging of low-abundance biomarkers in a tissue matrix. Suggett, DJ & van Oppen, MJH 2022, 'Horizon scan of rapidly advancing coral restoration approaches for 21st century reef management', Emerging Topics in Life Sciences, vol. 6, no. 1, pp. 125-136. Suggett, DJ, Nitschke, MR, Hughes, DJ, Bartels, N, Camp, EF, Dilernia, N, Edmondson, J, Fitzgerald, S, Grima, A, Sage, A & Warner, ME 2022, 'Toward bio‐optical phenotyping of reef‐forming corals using Light‐Induced Fluorescence Sukjamnong, S, Chen, H, Saad, S & Santiyanont, R 2022, 'Fimbristylis ovata and Artemisia vulgaris extracts inhibited AGE-mediated RAGE expression, ROS generation, and inflammation in THP-1 cells', Toxicological Research, vol. 38, no. 3, pp. 331-343. Sun, F, Liu, M, Wang, B, Yang, N, Wang, J, Cai, K & Liu, Z 2022, 'Properties of 3D Double-Arrow Negative Poisson’s Ratio Lattice Structure under Quasi-Static Compression and Low-Speed Impact', Advances in Materials Science and Engineering, vol. 2022, pp. 1-18. Suzzi, AL, Stat, M, MacFarlane, GR, Seymour, JR, Williams, NLR, Gaston, TF, Alam, MR & Huggett, MJ 2022, 'Legacy metal contamination is reflected in the fish gut microbiome in an urbanised estuary', Environmental Pollution, vol. 314, pp. 120222-120222. Sweeney, S, Bateson, D, Fleming, K & Huston, W 2022, 'Factors associated with pelvic inflammatory disease: A case series analysis of family planning clinic data', Women's Health, vol. 18, pp. 174550572211122-174550572211122. Szpila, K, Johnston, NP, Akbarzadeh, K, Richet, R & Tofilski, A 2022, 'Wing measurements are a possible tool for the identification of European forensically important Sarcophagidae', Forensic Science International, vol. 340, pp. 111451-111451. The flesh flies are a group of insects well known for their forensic importance. Reliable identification of these flies relies on the use of either molecular markers or the morphology of the male genital apparatus. Identification of female flesh flies is more time consuming and less reliable than their male counterparts. This is particularly problematic for forensic entomology practitioners, because female flesh flies are more abundant than males in carrion arthropod assemblages. As such, it is critical that alternative methods for flesh fly identification are established that are equally effective for both sexes. One promising technique is the use of wing measurements, which have been shown to be reliable for the identification of some groups of necrophagous Diptera from several geographical regions. We applied this method to the European Sarcophagidae for the first time, using a dataset of 881 specimens representing 29 species and 5 genera. Species identifications were based on 15 landmarks located at wing vein junctions. We also combined our results with data from previous studies of Calliphoridae and Muscidae which utilised the same methodology, enabling the testing of family level identification using wing morphometrics. Species identifications using wing measurements had varied success. While some species were successfully identified without error, others, particularly from the genus Sarcophaga, were often misclassified. Notably, in several species wing measurements successfully identified both males and females. The results presented here suggest that wing measurements are a promising complementary method to other methods for the identification of necrophagous Sarcophagidae especially in material unsorted at the family level. It can also be used to double check identification performed by a taxonomist using traditional methods. Tai, MC, Arnold, MD, Estherby, C, de Silva, KSB, Gentle, AR, Cortie, DL, Mitchell, DRG, Westerhausen, MT & Cortie, MB 2022, 'Spontaneous Emergence of Optically Polarizing Nanoscale Structures by Co-Deposition of Aluminum with Refractory Metals: Implications for High-Temperature Polarizers', ACS Applied Nano Materials, vol. 5, no. 3, pp. 4316-4324. The unexpected growth of highly aligned and optically polarizing metallic fins during physical vapor deposition under modestly oblique conditions is investigated. The fins exhibit nanoscale dimensions and are formed when Al is co-sputtered with any of V, Cr, Nb, Mo, Ta, W, Ru, Fe, Ni, Pt, Zr, Mg, and Ti. It is proposed that the phenomenon is caused by anomalously low atomic mobility in the alloys and intermetallic compounds formed by co-depositing with Al. In contrast, when Cu, Ag, and Au (which diffuse more rapidly in Al) are deposited, no fins form. There is a sharp visible transition in optical properties as the ratio of Al to other element is decreased: the color of the sample changes from black to silver-white for compositions containing less than about 55 atom % Al. The region over which the color change occurs is associated with a very strongly polarized reflectance. Cross-sectional elemental mapping and Monte Carlo simulations suggest that growth of the fins may be nucleated by Al hillocks and enhanced by shadowing effects. The diversity of suitable metals makes this a versatile technique for producing nanoscale polarizing surfaces suitable for high-flux and high-temperature applications. Tajaddini, A, Kendig, MD, Prates, KV, Westbrook, RF & Morris, MJ 2022, 'Male Rat Offspring Are More Impacted by Maternal Obesity Induced by Cafeteria Diet than Females—Additive Effect of Postweaning Diet', International Journal of Molecular Sciences, vol. 23, no. 3, pp. 1442-1442. Tan, CL, Chan, Y, Candasamy, M, Chellian, J, Madheswaran, T, Sakthivel, LP, Patel, VK, Chakraborty, A, MacLoughlin, R, Kumar, D, Verma, N, Malyla, V, Gupta, PK, Jha, NK, Thangavelu, L, Devkota, HP, Bhatt, S, Prasher, P, Gupta, G, Gulati, M, Singh, SK, Paudel, KR, Hansbro, PM, Oliver, BG, Dua, K & Chellappan, DK 2022, 'Unravelling the molecular mechanisms underlying chronic respiratory diseases for the development of novel therapeutics via in vitro experimental models', European Journal of Pharmacology, vol. 919, pp. 174821-174821. Tan, J, Walford, S-A, Dennis, ES & Llewellyn, DJ 2022, 'Erratum To: Trichomes at the Base of the Petal are Regulated by the Same Transcription Factors as Cotton Seed Fibers', Plant and Cell Physiology, vol. 63, no. 3, pp. 441-441. Tan, J, Wu, L, Peacock, J & Dennis, ES 2022, 'Capturing hybrid vigor for lentil breeding', Crop Science, vol. 62, no. 5, pp. 1787-1796. Tan, Q, Lai, J-M, Liu, X-L, Guo, D, Xue, Y, Dou, X, Sun, B-Q, Deng, H-X, Tan, P-H, Aharonovich, I, Gao, W & Zhang, J 2022, 'Donor–Acceptor Pair Quantum Emitters in Hexagonal Boron Nitride', Nano Letters, vol. 22, no. 3, pp. 1331-1337. Quantum emitters are needed for a myriad of applications ranging from quantum sensing to quantum computing. Hexagonal boron nitride (hBN) quantum emitters are one of the most promising solid-state platforms to date due to their high brightness and stability and the possibility of a spin-photon interface. However, the understanding of the physical origins of the single-photon emitters (SPEs) is still limited. Here we report dense SPEs in hBN across the entire visible spectrum and present evidence that most of these SPEs can be well explained by donor-acceptor pairs (DAPs). On the basis of the DAP transition generation mechanism, we calculated their wavelength fingerprint, matching well with the experimentally observed photoluminescence spectrum. Our work serves as a step forward for the physical understanding of SPEs in hBN and their applications in quantum technologies. Tang, K, Gao, H, Xiao, J, Long, M, Chen, J, Liu, H & Wang, G 2022, 'Hierarchical Oα-rich Co3O4 nanoarray anchored on Ni foam with superior lithiophilicity enabling ultrastable lithium metal batteries', Chemical Engineering Journal, vol. 436, pp. 134698-134698. Lithium metal batteries (LMBs) are considered as the ultimate choice in the next-generation high performance energy-storage systems due to their outstanding theoretical energy density (≥500 Wh kg−1). However, the unavoidable dendrite issues and infinite volume change during repeated plating/stripping induce poor electrochemical performance and serious safety issues. Here, we designed and prepared an integrated Oα (O- or O22–)-rich Co3O4 nanoarrays anchored on Ni foam (Oα-Co3O4@NF) scaffold as a stable host for ultra-fast lithium metal infusion. Remarkably, the highly reactive Oα behaves low energy bonding and strong electron affinity, which are further verified by the results of density functional theory, giving rise to high lithiophilicity and inhibiting the dendrites formation effectively. Moreover, the by-product NiO formed on the NF during the calcination process combines with Oα-Co3O4 to display superior dual-wettability toward molten Li. As a result, the Oα-Co3O4@NF electrode achieves a Coulombic efficiency above 99.00% more than 450 cycles at a current density of 1 mA cm−2, and the Oα-Co3O4@NF-Li anode presents a super-long and stable lifetime of 800 h during the repeated plating/striping process. When coupled with a high-loading LiFePO4 cathode, the full cells deliver excellent rate capability and 88.96% capacity retention after 200 cycles under 0.5C. Tang, K, Xiao, J, Long, M, Chen, J, Gao, H & Liu, H 2022, 'Superlithiophilic N, S-codoped carbon on Ni foam as a stable 3D host for dendrite-free Li metal anodes', Sustainable Materials and Technologies, vol. 32, pp. e00408-e00408. Tang, K, Xiao, J, Long, M, Chen, J, Gao, H & Liu, H 2022, 'Yolk–shell structured sulfur composite cathode for high performance lithium–sulfur battery', Surface Innovations, vol. 10, no. 3, pp. 209-216. Tang, K, Xiao, J, Long, M, Chen, J, Gao, H, Liu, H & Wang, G 2022, 'Engineering a heteroatom-doped multidimensional carbon network for dendrite-free lithium metal anode', Materials Today Energy, vol. 24, pp. 100949-100949. Lithium metal anode (LMA) has attracted widespread attention on account of its highest theoretical capacity and low reduction potential. However, the practical application of LMA has been long hindered by safety concerns and huge volume change resulting from the inevitable lithium dendrites growth. Herein, a multidimensional framework consisting of commercial carbon cloth (CC) and N, S-codoped porous carbon (PNSC) net (CC@PNSC) is fabricated and applied for LMA. This CC@PNSC skeleton has a large specific surface area, and the local current density can be significantly decreased. In addition, the synergetic effect of nitrogen and sulfur codoping endows CC with enhanced lithiophilicity and even lithium plating behavior. More importantly, the in-situ formed Li3N and Li2S during the molten lithium infusion process facilitate Li+ transfer kinetics and effectively homogenize the Li+ flux diffusion. The as-prepared CC@PNSC-Li composite anode exhibits high specific capacity (3 mA h cm−2, 500 h) and impressive cycling stability with a flat voltage profile at a current density of 1 mA cm−2 (750 h). When paired with LiFePO4 (LFP), the LFP||CC@PNSC-Li cell delivers an extraordinary rate capacity (especially at 5C) and a long-term cycling lifespan at 1C (600 cycles and capacity retention of 89.06%). Tareen, AK, Khan, K, Iqbal, M, Golovynskyi, S, Zhang, Y, Mahmood, A, Mahmood, N, Long, J, Al-Ghamdi, A, Li, C & Zhang, H 2022, 'Recent advances in MXenes: new horizons in biomedical technologies', Materials Today Chemistry, vol. 26, pp. 101205-101205. Tareen, AK, Khan, K, Iqbal, M, Zhang, Y, Long, J, Mahmood, A, Mahmood, N, Xie, Z, Li, C & Zhang, H 2022, 'Recent advance in two-dimensional MXenes: New horizons in flexible batteries and supercapacitors technologies', Energy Storage Materials, vol. 53, pp. 783-826. MXenes (two dimensional (2D) transition metal (TM) carbides (TMCs), TM nitrides (TMNs), and TM carbonitrides (TMCNs) are emerged as future biggest 2D materials (2DMs) family with novel applications in different nanotechnological research in academic as well as industrial level. MXenes NMs have the potential to be classified as a “wonder material” in the category of 2D nanomaterials (NMs). MXenes were studied and synthesized for over a decade since their first discovery in 2011, and till now more than 50 members are experimentally studied and more than 100 are theoretically investigated. Synthesis techniques are not restricted to the first introduced top-down HF based etching method but new innovative synthesis methods, such as, water (H2O)-free etching, molten salts etching and bottom-up method, like Chemical vapor deposition (CVD) method etc were also studied, providing multifunctional surface chemistry based MXenes NMs with novel configuration, and desirable characteristics. MXenes are used as important components in a number of flexible energy storage devices (FESDs), for instance secondary batteries, supercapacitors (SCs), Micro-SCs (MSCs) and Micro-batteries (MBs), etc due to their distinctive layered structures, high electrochemical performance and fascinating functional capabilities. In this review, we first will discuss in detail the MXenes NMs synthesis methods, secondly selected properties, and third their applications in various FESDs. After that, we will summarize and discuss the most present problems associated with MXenes NMs synthesis and their applications in FESDs, and possible solutions to those problems. Finally we will discuss the presents interesting vision for the future progress of the MXenes-based NMs in wearable and FESDs, their limitations, and suggestions. Tareen, AK, Khan, K, Iqbal, M, Zhang, Y, Long, J, Nazeer, F, Mahmood, A, Mahmood, N, Shi, Z, Ma, C, Huan, W, Khan, MF, Yin, J, Li, C & Zhang, H 2022, 'Recent advances in novel graphene: new horizons in renewable energy storage technologies', Journal of Materials Chemistry C, vol. 10, no. 32, pp. 11472-11531. Tareen, AK, Khan, K, Iqbal, M, Zhang, Y, Xie, Z, Mahmood, A, Mahmood, N, Long, J, Li, C & Zhang, H 2022, 'Recent major advances and challenges in the emerging graphene-based nanomaterials in electrocatalytic fuel cell technology', Journal of Materials Chemistry C, vol. 10, no. 47, pp. 17812-17873. Tashima, T, Takashima, H, Schell, AW, Tran, TT, Aharonovich, I & Takeuchi, S 2022, 'Hybrid device of hexagonal boron nitride nanoflakes with defect centres and a nano-fibre Bragg cavity', Scientific Reports, vol. 12, no. 1, pp. 1-7. Tekwe, CD, Zhang, M, Carroll, RJ, Luan, Y, Xue, L, Zoh, RS, Carter, SJ, Allison, DB & Geraci, M 2022, 'Estimation of sparse functional quantile regression with measurement error: a SIMEX approach', Biostatistics, vol. 23, no. 4, pp. 1218-1241. Thomson, S, Chan, YL, Yi, C, Wang, B, Machaalani, R, Oliver, BG, Gorrie, CA & Chen, H 2022, 'Impact of High Fat Consumption on Neurological Functions after Traumatic Brain Injury in Rats', Journal of Neurotrauma, vol. 39, no. 21-22, pp. 1547-1560. Tiotiu, A, Badi, Y, Kermani, NZ, Sanak, M, Kolmert, J, Wheelock, CE, Hansbro, PM, Dahlén, S-E, Sterk, PJ, Djukanovic, R, Guo, Y, Mumby, S, Adcock, IM, Chung, KF, Hoda, U, Rossios, C, Bel, E, Rao, N, Myles, D, Compton, C, Van Geest, M, Howarth, P, Roberts, G, Lefaudeux, D, De Meulder, B, Bansal, AT, Knowles, R, Erzen, D, Wagers, S, Krug, N, Higenbottam, T, Matthews, J, Erpenbeek, V, Carayannopoulos, L, Roberts, A, Supple, D, deBoer, P, Caruso, M, Chanez, P, Horváth, I, Musial, J & Sandström, T 2022, 'Association of Differential Mast Cell Activation with Granulocytic Inflammation in Severe Asthma', American Journal of Respiratory and Critical Care Medicine, vol. 205, no. 4, pp. 397-411. BACKGROUND: Mast cells (MC) play a role in inflammation and both innate and adaptive immunity but their involvement in severe asthma (SA) remains undefined. OBJECTIVE: We investigated the phenotypic characteristics of the U-BIOPRED asthma cohort by applying published MC activation signatures to the sputum cell transcriptome. METHODS: 84 SA, 20 mild/moderate (MMA) asthma, and 16 non-asthmatic healthy participants were studied. We calculated enrichment scores (ES) for nine MC activation signatures by asthma severity, sputum granulocyte status and three previously-defined sputum molecular phenotypes or transcriptome-associated clusters (TAC1, 2, 3) using gene-set variation analysis. RESULTS: MC signatures except unstimulated, repeated FcεR1-stimulated and IFNγ-stimulated were enriched in SA. A FcεR1-IgE-stimulated and a single cell signature from asthmatic bronchial biopsies were highly enriched in eosinophilic asthma and in the TAC1 molecular phenotype. Subjects with a high ES for these signatures had elevated sputum levels of similar genes and pathways. IL-33- and LPS-stimulated MC signatures had greater ES in neutrophilic and mixed granulocytic asthma and in the TAC2 molecular phenotype. These subjects exhibited neutrophil, NF-κB, and IL-1β/TNFα pathway activation. The IFNγ-stimulated signature had the greatest ES in TAC2 and TAC3 that was associated with responses to viral infection. Similar results were obtained in an independent ADEPT asthma cohort. CONCLUSIONS: Gene signatures of MC activation allow the detection of SA phenotypes and indicate that MC can be induced to take on distinct transcriptional phenotypes associated with specific clinical phenotypes. IL-33-stimulated MCs signature was associated with severe neutrophilic asthma while IgE-activated MC with an eosinophilic phenotype. Tou, K, Cawley, A, Bowen, C, Sornalingam, K & Fu, S 2022, 'Measurements of hydrocortisone and cortisone for longitudinal profiling of equine plasma by liquid chromatography–tandem mass spectrometry', Drug Testing and Analysis, vol. 14, no. 5, pp. 943-952. TOWNSEND, KD 2022, 'SYLOW CLASSES OF REFLECTION SUBGROUPS AND PSEUDO-LEVI SUBGROUPS', Bulletin of the Australian Mathematical Society, vol. 106, no. 3, pp. 508-510. Tran, KB, Lang, JJ, Compton, K, Xu, R, Acheson, AR, Henrikson, HJ, Kocarnik, JM, Penberthy, L, Aali, A, Abbas, Q, Abbasi, B, Abbasi-Kangevari, M, Abbasi-Kangevari, Z, Abbastabar, H, Abdelmasseh, M, Abd-Elsalam, S, Abdelwahab, AA, Abdoli, G, Abdulkadir, HA, Abedi, A, Abegaz, KH, Abidi, H, Aboagye, RG, Abolhassani, H, Absalan, A, Abtew, YD, Abubaker Ali, H, Abu-Gharbieh, E, Achappa, B, Acuna, JM, Addison, D, Addo, IY, Adegboye, OA, Adesina, MA, Adnan, M, Adnani, QES, Advani, SM, Afrin, S, Afzal, MS, Aggarwal, M, Ahinkorah, BO, Ahmad, AR, Ahmad, R, Ahmad, S, Ahmad, S, Ahmadi, S, Ahmed, H, Ahmed, LA, Ahmed, MB, Ahmed Rashid, T, Aiman, W, Ajami, M, Akalu, GT, Akbarzadeh-Khiavi, M, Aklilu, A, Akonde, M, Akunna, CJ, Al Hamad, H, Alahdab, F, Alanezi, FM, Alanzi, TM, Alessy, SA, Algammal, AM, Al-Hanawi, MK, Alhassan, RK, Ali, BA, Ali, L, Ali, SS, Alimohamadi, Y, Alipour, V, Aljunid, SM, Alkhayyat, M, Al-Maweri, SAA, Almustanyir, S, Alonso, N, Alqalyoobi, S, Al-Raddadi, RM, Al-Rifai, RHH, Al-Sabah, SK, Al-Tammemi, AB, Altawalah, H, Alvis-Guzman, N, Amare, F, Ameyaw, EK, Aminian Dehkordi, JJ, Amirzade-Iranaq, MH, Amu, H, Amusa, GA, Ancuceanu, R, Anderson, JA, Animut, YA, Anoushiravani, A, Anoushirvani, AA, Ansari-Moghaddam, A, Ansha, MG, Antony, B, Antwi, MH, Anwar, SL, Anwer, R, Anyasodor, AE, Arabloo, J, Arab-Zozani, M, Aremu, O, Argaw, AM, Ariffin, H, Aripov, T, Arshad, M, Artaman, A, Arulappan, J, Aruleba, RT, Aryannejad, A, Asaad, M, Asemahagn, MA, Asemi, Z, Asghari-Jafarabadi, M, Ashraf, T, Assadi, R, Athar, M, Athari, SS, Atout, MMW, Attia, S, Aujayeb, A, Ausloos, M, Avila-Burgos, L, Awedew, AF, Awoke, MA, Awoke, T, Ayala Quintanilla, BP, Ayana, TM, Ayen, SS, Azadi, D, Azadnajafabad, S, Azami-Aghdash, S, Azanaw, MM, Azangou-Khyavy, M, Azari Jafari, A, Azizi, H, Azzam, AYY, Babajani, A, Badar, M, Badiye, AD, Baghcheghi, N, Bagheri, N, Bagherieh, S, Bahadory, S, Baig, AA, Baker, JL, Bakhtiari, A, Bakshi, RK, Banach, M, Banerjee, I, Bardhan, M, Barone-Adesi, F, Barra, F, Barrow, A, Bashir, NZ, Bashiri, A, Basu, S, Batiha, A-MM, Begum, A, Bekele, AB, Belay, AS, Belete, MA, Belgaumi, UI, Bell, AW, Belo, L, Benzian, H, Berhie, AY, Bermudez, ANC, Bernabe, E, Bhagavathula, AS, Bhala, N, Bhandari, BB, Bhardwaj, N, Bhardwaj, P, Bhattacharyya, K, Bhojaraja, VS, Bhuyan, SS, Bibi, S, Bilchut, AH, Bintoro, BS, Biondi, A & et al. 2022, 'The global burden of cancer attributable to risk factors, 2010–19: a systematic analysis for the Global Burden of Disease Study 2019', The Lancet, vol. 400, no. 10352, pp. 563-591. BACKGROUND: Understanding the magnitude of cancer burden attributable to potentially modifiable risk factors is crucial for development of effective prevention and mitigation strategies. We analysed results from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019 to inform cancer control planning efforts globally. METHODS: The GBD 2019 comparative risk assessment framework was used to estimate cancer burden attributable to behavioural, environmental and occupational, and metabolic risk factors. A total of 82 risk-outcome pairs were included on the basis of the World Cancer Research Fund criteria. Estimated cancer deaths and disability-adjusted life-years (DALYs) in 2019 and change in these measures between 2010 and 2019 are presented. FINDINGS: Globally, in 2019, the risk factors included in this analysis accounted for 4·45 million (95% uncertainty interval 4·01-4·94) deaths and 105 million (95·0-116) DALYs for both sexes combined, representing 44·4% (41·3-48·4) of all cancer deaths and 42·0% (39·1-45·6) of all DALYs. There were 2·88 million (2·60-3·18) risk-attributable cancer deaths in males (50·6% [47·8-54·1] of all male cancer deaths) and 1·58 million (1·36-1·84) risk-attributable cancer deaths in females (36·3% [32·5-41·3] of all female cancer deaths). The leading risk factors at the most detailed level globally for risk-attributable cancer deaths and DALYs in 2019 for both sexes combined were smoking, followed by alcohol use and high BMI. Risk-attributable cancer burden varied by world region and Socio-demographic Index (SDI), with smoking, unsafe sex, and alcohol use being the three leading risk factors for risk-attributable cancer DALYs in low SDI locations in 2019, whereas DALYs in high SDI locations mirrored the top three global risk factor rankings. From 2010 to 2019, global risk-attributable cancer deaths increased by 20·4% (12·6-28·4) and DALYs by 16·8% (8·8-25·0), with the greatest percentage increase in metabolic ri... Tran, VLT, Hortle, E, Britton, WJ & Oehlers, SH 2022, 'Common anti-haemostatic medications increase the severity of systemic infection by uropathogenic Escherichia coli', Microbiological Research, vol. 254, pp. 126918-126918. Trist, BG, Genoud, S, Roudeau, S, Rookyard, A, Abdeen, A, Cottam, V, Hare, DJ, White, M, Altvater, J, Fifita, JA, Hogan, A, Grima, N, Blair, IP, Kysenius, K, Crouch, PJ, Carmona, A, Rufin, Y, Claverol, S, Van Malderen, S, Falkenberg, G, Paterson, DJ, Smith, B, Troakes, C, Vance, C, Shaw, CE, Al-Sarraj, S, Cordwell, S, Halliday, G, Ortega, R & Double, KL 2022, 'Altered SOD1 maturation and post-translational modification in amyotrophic lateral sclerosis spinal cord', Brain, vol. 145, no. 9, pp. 3108-3130. Tsounis, C, Subhash, B, Kumar, PV, Bedford, NM, Zhao, Y, Shenoy, J, Ma, Z, Zhang, D, Toe, CY, Cheong, S, Tilley, RD, Lu, X, Dai, L, Han, Z & Amal, R 2022, 'Pt Single Atom Electrocatalysts at Graphene Edges for Efficient Alkaline Hydrogen Evolution', Advanced Functional Materials, vol. 32, no. 38. Tu, X, Kim, RY, Brown, AC, de Jong, E, Jones-Freeman, B, Ali, MK, Gomez, HM, Budden, KF, Starkey, MR, Cameron, GJM, Loering, S, Nguyen, DH, Nair, PM, Haw, TJ, Alemao, CA, Faiz, A, Tay, HL, Wark, PAB, Knight, DA, Foster, PS, Bosco, A, Horvat, JC, Hansbro, PM & Donovan, C 2022, 'Airway and parenchymal transcriptomics in a novel model of asthma and COPD overlap', Journal of Allergy and Clinical Immunology, vol. 150, no. 4, pp. 817-829.e6. BACKGROUND: Asthma and chronic obstructive pulmonary disease (COPD) are common chronic respiratory diseases, and some patients have overlapping disease features, termed asthma-COPD overlap (ACO). Patients characterized with ACO have increased disease severity; however, the mechanisms driving this have not been widely studied. OBJECTIVES: This study sought to characterize the phenotypic and transcriptomic features of experimental ACO in mice induced by chronic house dust mite antigen and cigarette smoke exposure. METHODS: Female BALB/c mice were chronically exposed to house dust mite antigen for 11 weeks to induce experimental asthma, cigarette smoke for 8 weeks to induce experimental COPD, or both concurrently to induce experimental ACO. Lung inflammation, structural changes, and lung function were assessed. RNA-sequencing was performed on separated airway and parenchyma lung tissues to assess transcriptional changes. Validation of a novel upstream driver SPI1 in experimental ACO was assessed using the pharmacological SPI1 inhibitor, DB2313. RESULTS: Experimental ACO recapitulated features of both asthma and COPD, with mixed pulmonary eosinophilic/neutrophilic inflammation, small airway collagen deposition, and increased airway hyperresponsiveness. Transcriptomic analysis identified common and distinct dysregulated gene clusters in airway and parenchyma samples in experimental asthma, COPD, and ACO. Upstream driver analysis revealed increased expression of the transcription factor Spi1. Pharmacological inhibition of SPI1 using DB2313, reduced airway remodeling and airway hyperresponsiveness in experimental ACO. CONCLUSIONS: A new experimental model of ACO featuring chronic dual exposures to house dust mite and cigarette smoke mimics key disease features observed in patients with ACO and revealed novel disease mechanisms, including upregulation of SPI1, that are amenable to therapy. Turan, Y, Kalkandelen, C, Palaci, Y, Sahin, A, Gokce, H, Gunduz, O & Ben-Nissan, B 2022, 'Synthesis and cytotoxicity analysis of porous β-TCP/starch bioceramics', Journal of the Australian Ceramic Society, vol. 58, no. 2, pp. 487-494. Turpin, GA, Nelson, A, Holt, SA, Giles, LW, Milogrodzka, I, Teo, BM, Raghuwanshi, VS, Horn, RG, van 't Hag, L & Tabor, RF 2022, 'Investigating Adsorption of Cellulose Nanocrystals at Air–Liquid and Solid–Liquid Interfaces in the Presence of Hydrotropes', Advanced Materials Interfaces, vol. 9, no. 31. 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Elastic fibers are an essential part of the pulmonary extracellular matrix (ECM). Intact elastin is required for normal function and its damage contributes profoundly to the etiology and pathology of lung disease. This highlights the need for novel lung-specific imaging methodology that enables high-resolution 3D visualization of the ECM. We consider elastin's involvement in chronic respiratory disease and examine recent methods for imaging and modeling of the lung in the context of advances in lung tissue engineering for research and clinical application. Vo, HNP, Nguyen, TMH, Ngo, HH, Guo, W & Shukla, P 2022, 'Biochar sorption of perfluoroalkyl substances (PFASs) in aqueous film-forming foams-impacted groundwater: Effects of PFASs properties and groundwater chemistry', Chemosphere, vol. 286, no. Pt 1, pp. 131622-131622. The widespread use of per- and polyfluoroalkyl substances (PFASs)-related products such as aqueous film-forming foams (AFFF) has led to increasing contamination of groundwater systems. The concentration of PFASs in AFFF-impacted groundwater can be several orders of magnitude higher than the drinking water standard. There is a need for a sustainable and effective sorbent to remove PFASs from groundwater. This work aims to investigate the sorption of PFASs in groundwater by biochar column. The specific objectives are to understand the influences of PFASs properties and groundwater chemistry to PFASs sorption by biochar. The PFASs-spiked Milli-Q water (including 19 PFASs) and four aqueous film-forming foams (AFFF)-impacted groundwater were used. The partitioning coefficients (log Kd) of long chain PFASs ranged from 0.77 to 4.63 while for short chain PFASs they remained below 0.68. For long chain PFASs (C ≥ 7), log Kd increased by 0.5 and 0.8 for each CF2 moiety of PFCAs and PFSAs, respectively. Dissolved organic matter (DOM) was the most influential factor in PFASs sorption over pH, salinity, and specific ultraviolet absorbance (SUVA). DOM contained hydrophobic compounds and metal ions which can form DOM-PFASs complexes to provide more sorption sites for PFASs. The finding is useful for executing PFASs remediation by biochar filtration column, especially legacy long chain PFASs, for groundwater remediation. Vuitika, L, Prates-Syed, WA, Silva, JDQ, Crema, KP, Côrtes, N, Lira, A, Lima, JBM, Camara, NOS, Schimke, LF, Cabral-Marques, O, Sadraeian, M, Chaves, LCS & Cabral-Miranda, G 2022, 'Vaccines against Emerging and Neglected Infectious Diseases: An Overview', Vaccines, vol. 10, no. 9, pp. 1385-1385. 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Wang, N, Yao, H, Tao, Q, Sun, J, Ma, H, Wang, Y, Zhou, C, Fan, H, Shao, H, Qin, A, Su, D, Wang, C & Chong, H 2022, 'TPE based aggregation induced emission fluorescent sensors for viscosity of liquid and mechanical properties of hydrogel', Chinese Chemical Letters, vol. 33, no. 1, pp. 252-256. Two amphiphilic TPE E/Z isomers with aggregation induced emission (AIE) property have been synthesized and characterized. The logarithmic fluorescent intensity of the two molecules was in positive relationship with logarithmic viscosity of liquid. To note, the Z-TPE isomer exhibited more sensitivity in the viscosity of liquid sensing in comparison with the corresponding E-TPE counterpart (around 1.80 folds). Furthermore, two molecules could be used as fluorescent sensors for mechanical properties (viscosity and storage modulus) of hydrogel as well. In addition, two sensors displayed low cytotoxicity in normal tissue cell line (L929) within the concentration range of 2–10 µmol/L. These results potentially promised their applications as fluorescent sensors for mechanical properties in the fields of biological and biomedical. Wang, Q, Huang, X, Su, Y, Yin, G, Wang, S, Yu, B, Li, H, Qi, J, Chen, H, Zeng, W, Zhang, K, Verkhratsky, A, Niu, J & Yi, C 2022, 'Activation of Wnt/β-catenin pathway mitigates blood–brain barrier dysfunction in Alzheimer’s disease', Brain, vol. 145, no. 12, pp. 4474-4488. Wang, S, Zhao, S, Guo, X & Wang, G 2022, '2D Material‐Based Heterostructures for Rechargeable Batteries', Advanced Energy Materials, vol. 12, no. 4, pp. 2100864-2100864. Wang, T, He, D, Yao, H, Guo, X, Sun, B & Wang, G 2022, 'Development of Proteins for High‐Performance Energy Storage Devices: Opportunities, Challenges, and Strategies', Advanced Energy Materials, vol. 12, no. 44, pp. 2202568-2202568. Wang, Y, Cui, X, Zhang, J, Qiao, J, Huang, H, Shi, J & Wang, G 2022, 'Advances of atomically dispersed catalysts from single-atom to clusters in energy storage and conversion applications', Progress in Materials Science, vol. 128, pp. 100964-100964. Owing to the special structural characteristics and maximized efficiency, atomically dispersed catalysts (ADCs) with different atom sizes ranged from the single atom to clusters can bridge the gap between heterogeneous and homogeneous catalysis. Tremendous progress has been made in ADCs including developing advanced synthesis strategies, promoting electrochemical performance and unraveling the underlying fundamental mechanisms. Herein, the recent progress of ADCs ranged from single-atom to clusters has been systematically reviewed with emphasis on key issues of synthesis methods, stabilization strategies, performance evaluation, mechanistic understanding, integrated experimental and theoretical studies in typical applications of energy storage and conversion, including oxygen reduction reaction in fuel cell and metal-air battery, oxygen evolution and hydrogen evolution reactions in water splitting, hydrogen oxidation reactions, carbon dioxide reduction and nitrogen reduction reaction. Centering on the topics, the most up-to-date results are present, along with the perspectives and challenges for the future development of ADCs. Wang, Y, Wang, X, Luu, LDW, Li, J, Cui, X, Yao, H, Chen, S, Fu, J, Wang, L, Wang, C, Yuan, R, Cai, Q, Huang, X, Huang, J, Li, Z, Li, S, Zhu, X & Tai, J 2022, 'Single‐cell transcriptomic atlas reveals distinct immunological responses between COVID‐19 vaccine and natural SARS‐CoV‐2 infection', Journal of Medical Virology, vol. 94, no. 11, pp. 5304-5324. Wang, Y, Yang, X, Zhang, Z, Hu, X, Meng, Y, Wang, X, Zhou, D, Liu, H, Li, B & Wang, G 2022, 'Electrolyte design for rechargeable anion shuttle batteries', eScience, vol. 2, no. 6, pp. 573-590. As an emerging new type of battery chemistry, the anion shuttle battery (ASB), based on the shuttling and storage of anions, is considered a sustainable alternative to gigawatt-scale energy storage due to the associated resource abundance, low cost, high safety, and high energy density. Although significant progress has been achieved, practical applications of ASBs are still hindered by tough challenges, such as short lifetime, limited reversible capacity, and low Coulombic efficiency. Therefore, it is very necessary to design and explore new electrolyte systems with high electrochemical/chemical stability, sufficient compatibility towards electrodes, and excellent kinetics/reversibility for anion electrochemical reactions. Here, we review the recent achievements and main challenges in developing electrolytes for ASBs, which include solid, non-aqueous, and aqueous electrolytes. We mainly focus on the unique properties and basic principles of designing these electrolytes, and their various performance parameters. Perspectives on design strategies for ASB electrolytes are also presented, which could facilitate the development of advanced ASBs for grid-scale energy storage. Wang, Z, Kuang, T, Wu, W, Wang, D, Lou, W, Jin, D, Xu, X & Zhang, L 2022, 'GFAT1 is highly expressed in cancer stem cells of pancreatic cancer', Annals of Translational Medicine, vol. 10, no. 10, pp. 544-544. Wang, Z, Wang, Z, Rahman, MA, Ton-That, C & Ling, FCC 2022, 'Convertible Green Luminescence Determined by Surface Band Bending in ZnO', The Journal of Physical Chemistry C, vol. 126, no. 8, pp. 4082-4088. Green luminescence (GL) of ZnO is a typical defect emission and an important research topic for defect-controlling engineering. Two kinds of spectral characteristics, namely, Gaussian GL (GGL) and fine-structure GL (FSGL), are designated from a variety of spectra. It is found that GGL and FSGL can be reversibly converted through surface modification techniques where the location of the recombination center, the surface state, or the degree of band bending is modified. This convertible feature proves that the carrier recombination could be precisely controlled by surface modification. On the other hand, the effect of surface treatment on defects has achieved an unambiguous understanding, which is beneficial to effectively improve the performance of ZnO devices. Wangpraseurt, D, Sun, Y, You, S, Chua, S, Noel, SK, Willard, HF, Berry, DB, Clifford, AM, Plummer, S, Xiang, Y, Hwang, HH, Kaandorp, J, Diaz, JM, La Jeunesse, TC, Pernice, M, Vignolini, S, Tresguerres, M & Chen, S 2022, 'Bioprinted Living Coral Microenvironments Mimicking Coral‐Algal Symbiosis', Advanced Functional Materials, vol. 32, no. 35, pp. 1-11. Ward, J 2022, 'A multifaceted, multijurisdictional, multiagency, and multidisciplinary approach to investigating unidentified and missing persons cases in Australia', Forensic Science International: Genetics Supplement Series, vol. 8, pp. 53-55. Watanabe, S, Iwai, T, Matsushita, R, Nakanishi, T, Kuzhiumparambil, U, Fu, S & Seto, Y 2022, 'Comparison between human liver microsomes and the fungus Cunninghamella elegans for biotransformation of the synthetic cannabinoid JWH-424 having a bromo-naphthyl moiety analysed by high-resolution mass spectrometry', Forensic Toxicology, vol. 40, no. 2, pp. 278-288. Watherston, J, Watson, J, Bruce, D, Ueland, M, McNevin, D & Ward, J 2022, 'An in-field evaluation of rapid DNA instruments for disaster victim identification', International Journal of Legal Medicine, vol. 136, no. 2, pp. 493-499. In 2019 and 2020, disaster victim identification (DVI) simulations were conducted at the Australian Facility for Taphonomic Experimental Research. Whole and fragmented cadavers were positioned to replicate a building collapse scenario and left to decompose for up to 4 weeks. This study evaluated the utility of the ANDE™ 6C Rapid DNA System and the RapidHITTM ID System for DVI in the field and mortuary. Applying post-mortem nail and tissue biopsy samples showed promise, with the added benefit of minimally invasive collection procedures and limited preparation requirements. The preferred platform will depend on a number of factors, including its intended use and operating environment. Watson, P, O’Callaghan, C, Perkes, I, Bradfield, L & Turner, K 2022, 'Making habits measurable beyond what they are not: A focus on associative dual-process models', Neuroscience & Biobehavioral Reviews, vol. 142, pp. 104869-104869. Habits are the subject of intense international research. Under the associative dual-process model the outcome devaluation paradigm has been used extensively to classify behaviours as being either goal-directed (sensitive to shifts in the value of associated outcomes) or habitual (triggered by stimuli without anticipation of consequences). This has proven to be a useful framework for studying the neurobiology of habit and relevance of habits in clinical psychopathology. However, in recent years issues have been raised about this rather narrow definition of habits in comparison to habitual behaviour experienced in the real world. Specifically, defining habits as the absence of goal-directed control, the very specific set-ups required to demonstrate habit experimentally and the lack of direct evidence for habits as stimulus-response behaviours are viewed as problematic. In this review paper we address key critiques that have been raised about habit research within the framework of the associative dual-process model. We then highlight novel research approaches studying different features of habits with methods that expand beyond traditional paradigms. Webster, J, Kehoe, MA, Nogarotto, E, Falconer, L, Donovan, NJ & Chapman, TA 2022, 'Using Genomics to Design a Pathovar-Specific Loop-Mediated Isothermal Amplification (LAMP) Assay, for the Improved Detection of Xanthomonas citri pv. citri', Microorganisms, vol. 10, no. 6, pp. 1153-1153. Wen, S, Li, D, Liu, Y, Chen, C, Wang, F, Zhou, J, Bao, G, Zhang, L & Jin, D 2022, 'Power-Dependent Optimal Concentrations of Tm3+ and Yb3+ in Upconversion Nanoparticles', The Journal of Physical Chemistry Letters, vol. 13, no. 23, pp. 5316-5323. Lanthanide-doped upconversion nanoparticles (UCNPs) have enabled a broad range of emerging nanophotonics and biophotonics applications. Here, we provide a quantitative guide to the optimum concentrations of Yb3+ sensitizer and Tm3+ emitter ions, highly dependent on the excitation power densities. To achieve this, we fabricate the inert-core@active-shell@inert-shell architecture to sandwich the same volume of the optically active section. Our results show that highly doped UCNPs enable an approximately 18-fold enhancement in brightness over that of conventional ones. Increasing the Tm3+ concentration improves the brightness by 6 times and increases the NIR/blue ratio by 11 times, while the increase of Yb3+ concentration enhances the brightness by 3 times and only slightly affects the NIR/blue ratio. Moreover, the optimal doping concentration of Tm3+ varies from 2% to 16%, which is highly dependent on the excitation power density ranging from 102 to 107 W/cm2. This work provides a guideline for designing bright UCNPs under different excitation conditions. Werry, LP, Bundschuh, M, Mitrovic, SM, Lim, RP & Kefford, BJ 2022, 'Leaf litter breakdown along an elevational gradient in Australian alpine streams', Ecology and Evolution, vol. 12, no. 10. Wezenberg, SJ, Chen, L-J, Bos, JE, Feringa, BL, Howe, ENW, Wu, X, Siegler, MA & Gale, PA 2022, 'Photomodulation of Transmembrane Transport and Potential by Stiff-Stilbene Based Bis(thio)ureas', Journal of the American Chemical Society, vol. 144, no. 1, pp. 331-338. Membrane transport proteins fulfill important regulatory functions in biology with a common trait being their ability to respond to stimuli in the environment. Various small-molecule receptors, capable of mediating transmembrane transport, have been successfully developed. However, to confer stimuli-responsiveness on them poses a fundamental challenge. Here we demonstrate photocontrol of transmembrane transport and electric potential using bis(thio)ureas derived from stiff-stilbene. UV-vis and 1H NMR spectroscopy are used to monitor E-Z photoisomerization of these bis(thio)ureas and 1H NMR titrations reveal stronger binding of chloride to the (Z)-form than to the (E)-form. Additional insight into the binding properties is provided by single crystal X-ray crystallographic analysis and DFT geometry optimization. Importantly, the (Z)-isomers are much more active in transmembrane transport than the respective (E)-isomers as shown through various assays. As a result, both membrane transport and depolarization can be modulated upon irradiation, opening up new prospects toward light-based therapeutics as well as physiological and optopharmacological tools for studying anion transport-associated diseases and to stimulate neuronal activity, respectively. White, SJU, Yang, T, Dontschuk, N, Li, C, Xu, Z-Q, Kianinia, M, Stacey, A, Toth, M & Aharonovich, I 2022, 'Author Correction: Electrical control of quantum emitters in a Van der Waals heterostructure', Light: Science & Applications, vol. 11, no. 1, p. 226. White, SJU, Yang, T, Dontschuk, N, Li, C, Xu, Z-Q, Kianinia, M, Stacey, A, Toth, M & Aharonovich, I 2022, 'Electrical control of quantum emitters in a Van der Waals heterostructure', Light: Science & Applications, vol. 11, no. 1, pp. 1-9. Whitehead, SN, Bruno, A, Burns, JM, Carmichael, ST, Csiszar, A, Edwards, JD, Elahi, FM, Faraco, G, Gould, DB, Gustafson, DR, Hachinski, V, Rosenberg, G, Sorond, FA, Shih, AY, Tse, KH, Ungvari, Z, Wilcock, DM, Zuloaga, KL & Barone, FC 2022, 'Expanding the horizon of research into the pathogenesis of the white matter diseases: Proceedings of the 2021 Annual Workshop of the Albert Research Institute for White Matter and Cognition', GeroScience, vol. 44, no. 1, pp. 25-37. Wilder, BK, Vigdorovich, V, Carbonetti, S, Minkah, N, Hertoghs, N, Raappana, A, Cardamone, H, Oliver, BG, Trakhimets, O, Kumar, S, Dambrauskas, N, Arredondo, SA, Camargo, N, Seilie, AM, Murphy, SC, Kappe, SHI & Sather, DN 2022, 'Anti-TRAP/SSP2 monoclonal antibodies can inhibit sporozoite infection and may enhance protection of anti-CSP monoclonal antibodies', npj Vaccines, vol. 7, no. 1. Wilkes Walburn, J, Rourke, ML, Furlan, E, DiBattista, JD, Broadhurst, MK, Fowler, AM, Hughes, JM & Fielder, S 2022, 'Robust environmental DNA assay development and validation: A case study with two vulnerable Australian fish', Aquatic Conservation: Marine and Freshwater Ecosystems, vol. 32, no. 7, pp. 1225-1231. Wille, M, Grillo, V, Ban de Gouvea Pedroso, S, Burgess, GW, Crawley, A, Dickason, C, Hansbro, PM, Hoque, MA, Horwood, PF, Kirkland, PD, Kung, NY-H, Lynch, SE, Martin, S, McArthur, M, O’Riley, K, Read, AJ, Warner, S, Hoye, BJ, Lisovski, S, Leen, T, Hurt, AC, Butler, J, Broz, I, Davies, KR, Mileto, P, Neave, MJ, Stevens, V, Breed, AC, Lam, TTY, Holmes, EC, Klaassen, M & Wong, FYK 2022, 'Australia as a global sink for the genetic diversity of avian influenza A virus', PLOS Pathogens, vol. 18, no. 5, pp. e1010150-e1010150. Williams, NLR, Siboni, N, King, WL, Balaraju, V, Bramucci, A & Seymour, JR 2022, 'Latitudinal Dynamics of Vibrio along the Eastern Coastline of Australia', Water, vol. 14, no. 16, pp. 2510-2510. Williams, NLR, Siboni, N, McLellan, SL, Potts, J, Scanes, P, Johnson, C, James, M, McCann, V & Seymour, JR 2022, 'Rainfall leads to elevated levels of antibiotic resistance genes within seawater at an Australian beach', Environmental Pollution, vol. 307, pp. 119456-119456. Anthropogenic waste streams can be major sources of antibiotic resistant microbes within the environment, creating a potential risk to public health. We examined patterns in the occurrence of a suite of antibiotic resistance genes (ARGs) and their links to enteric bacteria at a popular swimming beach in Australia that experiences intermittent contamination by sewage, with potential points of input including stormwater drains and a coastal lagoon. Samples were collected throughout a significant rainfall event (40.8 mm over 3 days) and analysed using both qPCR and 16S rRNA amplicon sequencing. Before the rainfall event, low levels of faecal indicator bacteria and a microbial source tracking human faeces (sewage) marker (Lachno3) were observed. These levels increased over 10x following rainfall. Within lagoon, drain and seawater samples, levels of the ARGs sulI, dfrA1 and qnrS increased by between 1 and 2 orders of magnitude after 20.4 mm of rain, while levels of tetA increased by an order of magnitude after a total of 40.8 mm. After 40.8 mm of rain sulI, tetA and qnrS could be detected 300 m offshore with levels remaining high five days after the rain event. Highest levels of sewage markers and ARGs were observed adjacent to the lagoon (when opened) and in-front of the stormwater drains, pinpointing these as the points of ARG input. Significant positive correlations were observed between all ARGs, and a suite of Amplicon Sequence Variants that were identified as stormwater drain indicator taxa using 16S rRNA amplicon sequencing data. Of note, some stormwater drain indicator taxa, which exhibited correlations to ARG abundance, included the human pathogens Arcobacter butzleri and Bacteroides fragilis. Given that previous research has linked high levels of ARGs in recreationally used environments to antimicrobial resistant pathogen infections, the observed patterns indicate a potentially elevated human health risk at a popular swimming beach following signif... Williams, NLR, Siboni, N, Potts, J, Campey, M, Johnson, C, Rao, S, Bramucci, A, Scanes, P & Seymour, JR 2022, 'Molecular microbiological approaches reduce ambiguity about the sources of faecal pollution and identify microbial hazards within an urbanised coastal environment', Water Research, vol. 218, pp. 118534-118534. Urbanised beaches are regularly impacted by faecal pollution, but management actions to resolve the causes of contamination are often obfuscated by the inability of standard Faecal Indicator Bacteria (FIB) analyses to discriminate sources of faecal material or detect other microbial hazards, including antibiotic resistance genes (ARGs). We aimed to determine the causes, spatial extent, and point sources of faecal contamination within Rose Bay, a highly urbanised beach within Sydney, Australia's largest city, using molecular microbiological approaches. Sampling was performed across a network of transects originating at 9 stormwater drains located on Rose Bay beach over the course of a significant (67.5 mm) rainfall event, whereby samples were taken 6 days prior to any rain, on the day of initial rainfall (3.8 mm), three days later after 43 mm of rain and then four days after any rain. Quantitative PCR (qPCR) was used to target marker genes from bacteria (i.e., Lachnospiraceae and Bacteroides) that have been demonstrated to be specific to human faeces (sewage), along with gene sequences from Heliobacter and Bacteriodes that are specific to bird and dog faeces respectively, and ARGs (sulI, tetA, qnrS, dfrA1 and vanB). 16S rRNA gene amplicon sequencing was also used to discriminate microbial signatures of faecal contamination. Prior to the rain event, low FIB levels (mean: 2.4 CFU/100 ml) were accompanied by generally low levels of the human and animal faecal markers, with the exception of one transect, potentially indicative of a dry weather sewage leak. Following 43 mm of rain, levels of both human faecal markers increased significantly in stormwater drain and seawater samples, with highest levels of these markers pinpointing several stormwater drains as sources of sewage contamination. During this time, sewage contamination was observed up to 1000 m from shore and was significantly and positively correlated with often highly elevated levels of the ARGs d... Wilson, BS, Peiser-Oliver, J, Gillis, A, Evans, S, Alamein, C, Mostyn, SN, Shimmon, S, Rawling, T, Christie, MJ, Vandenberg, RJ & Mohammadi, SA 2022, 'Peripheral Administration of Selective Glycine Transporter-2 Inhibitor, Oleoyl-D-Lysine, Reverses Chronic Neuropathic Pain but Not Acute or Inflammatory Pain in Male Mice', The Journal of Pharmacology and Experimental Therapeutics, vol. 382, no. 3, pp. 246-255. Aberrations in spinal glycinergic signaling are a feature of pain chronification. Normalizing these changes by inhibiting glycine transporter (GlyT)-2 is a promising treatment strategy. However, existing GlyT2 inhibitors (e.g., ORG25543) are limited by narrow therapeutic windows and severe dose-limiting side effects, such as convulsions, and are therefore poor candidates for clinical development. Here, intraperitoneally administered oleoyl-D-lysine, a lipid-based GlyT2 inhibitor, was characterized in mouse models of acute (hot plate), inflammatory (complete Freund's adjuvant), and chronic neuropathic (chronic constriction injury) pain. Side effects were also assessed on a numerical rating score, convulsions score, for motor incoordination (rotarod), and for respiratory depression (whole body plethysmography). Oleoyl-D-lysine produced near complete antiallodynia for chronic neuropathic pain, but no antiallodynia/analgesia in inflammatory or acute pain. No side effects were seen at the peak analgesic dose, 30 mg/kg. Mild side effects were observed at the highest dose, 100 mg/kg, on the numerical rating score, but no convulsions. These results contrasted markedly with ORG25543, which reached less than 50% reduction in allodynia score only at the lethal/near-lethal dose of 50 mg/kg. At this dose, ORG25543 caused maximal side effects on the numerical rating score and severe convulsions. Oleoyl-D-lysine (30 mg/kg) did not cause any respiratory depression, a problematic side effect of opiates. These results show the safe and effective reversal of neuropathic pain in mice by oleoyl-D-lysine and provide evidence for a distinct role of glycine in chronic pain over acute or short-term pain conditions. SIGNIFICANCE STATEMENT: Partially inhibiting glycine transporter (GlyT)-2 can alleviate chronic pain by restoring lost glycinergic function. Novel lipid-based GlyT2 inhibitor ol-D-lys is safe and effective in alleviating neuropathic pain, but not inflammatory or acut... Windhagauer, M, Abbriano, RM, Pittrich, DA & Doblin, MA 2022, 'Phosphate-inducible poly-hydroxy butyrate production dynamics in CO2 supplemented upscaled cultivation of engineered Phaeodactylum tricornutum', Journal of Applied Phycology, vol. 34, no. 5, pp. 2259-2270. Winskel‐Wood, B, Padula, MP, Marks, DC & Johnson, L 2022, 'Cold storage alters the immune characteristics of platelets and potentiates bacterial‐induced aggregation', Vox Sanguinis, vol. 117, no. 8, pp. 1006-1015. Wooster, EIF, Fleck, R, Torpy, F, Ramp, D & Irga, PJ 2022, 'Urban green roofs promote metropolitan biodiversity: A comparative case study', Building and Environment, vol. 207, pp. 108458-108458. Worden, PJ, Bogema, DR, Micallef, ML, Go, J, Deutscher, AT, Labbate, M, Green, TJ, King, WL, Liu, M, Seymour, JR & Jenkins, C 2022, 'Phylogenomic diversity of Vibrio species and other Gammaproteobacteria isolated from Pacific oysters (Crassostrea gigas) during a summer mortality outbreak', Microbial Genomics, vol. 8, no. 12. Wright, AS, Doblin, MA & Scanes, PR 2022, 'Improper Maintenance Activities Alter Benefits of Urban Stormwater Treatment in a Temperate Constructed Wetland in NSW, Australia', Frontiers in Environmental Chemistry, vol. 3, pp. 1-14. Wu, C, Lei, Y, Simonelli, L, Tonti, D, Black, A, Lu, X, Lai, W, Cai, X, Wang, Y, Gu, Q, Chou, S, Liu, H, Wang, G & Dou, S 2022, 'Continuous Carbon Channels Enable Full Na‐Ion Accessibility for Superior Room‐Temperature Na–S Batteries', Advanced Materials, vol. 34, no. 8, pp. e2108363-2108363. Wu, C, Lei, Y, Simonelli, L, Tonti, D, Black, A, Marini, C, Lu, X, Lai, W, Cai, X, Wang, Y, Gu, Q, Chou, S, Liu, H, Wang, G & Dou, S 2022, 'Continuous Carbon Channels Enable Full Na‐Ion Accessibility for Superior Room‐Temperature Na–S Batteries', Advanced Materials, vol. 34, no. 39. Wu, J, Tian, Y, Gao, Y, Gao, Z, Meng, Y, Wang, Y, Wang, X, Zhou, D, Kang, F, Li, B & Wang, G 2022, 'Rational Electrolyte Design toward Cyclability Remedy for Room‐Temperature Sodium–Sulfur Batteries', Angewandte Chemie International Edition, vol. 61, no. 30, p. e202205416. Wu, J, Tian, Y, Gao, Y, Gao, Z, Meng, Y, Wang, Y, Wang, X, Zhou, D, Kang, F, Li, B & Wang, G 2022, 'Rational Electrolyte Design toward Cyclability Remedy for Room‐Temperature Sodium–Sulfur Batteries', Angewandte Chemie, vol. 134, no. 30. Wu, X, Gilchrist, AM & Gale, PA 2022, 'Janus metal-organic layer functioning as a biomimetic photosynthetic reaction center', Chem, vol. 8, no. 3, pp. 604-606. Wu, X, Wang, P, Lewis, W, Jiang, Y-B & Gale, PA 2022, 'Measuring anion binding at biomembrane interfaces', Nature Communications, vol. 13, no. 1, p. 4623. Wuerz, M, Lawson, CA, Ueland, M, Oakley, CA, Grossman, AR, Weis, VM, Suggett, DJ & Davy, SK 2022, 'Symbiosis induces unique volatile profiles in the model cnidarian Aiptasia', Journal of Experimental Biology, vol. 225, no. 19, p. jeb244600. Wyrsch, ER, Bushell, RN, Marenda, MS, Browning, GF & Djordjevic, SP 2022, 'Global Phylogeny and F Virulence Plasmid Carriage in Pandemic Escherichia coli ST1193', Microbiology Spectrum, vol. 10, no. 6, p. e0255422. Wyrsch, ER, Nesporova, K, Tarabai, H, Jamborova, I, Bitar, I, Literak, I, Dolejska, M & Djordjevic, SP 2022, 'Urban Wildlife Crisis: Australian Silver Gull Is a Bystander Host to Widespread Clinical Antibiotic Resistance', mSystems, vol. 7, no. 3, p. e0015822. Xiao, J, Gao, H, Tang, K, Long, M, Chen, J, Liu, H & Wang, G 2022, 'Manipulating Stable Layered P2‐Type Cathode via a Co‐Substitution Strategy for High Performance Sodium Ion Batteries', Small Methods, vol. 6, no. 3, pp. e2101292-2101292. Xiao, J, Li, X, Tang, K, Long, M, Chen, J, Wang, D, Gao, H & Liu, H 2022, 'Enhanced electrochemical performance of Li-rich cathode material for lithium-ion batteries', Surface Innovations, vol. 10, no. 2, pp. 119-127. Xie, Q, Cleverly, J, Moore, CE, Ding, Y, Hall, CC, Ma, X, Brown, LA, Wang, C, Beringer, J, Prober, SM, Macfarlane, C, Meyer, WS, Yin, G & Huete, A 2022, 'Land surface phenology retrievals for arid and semi-arid ecosystems', ISPRS Journal of Photogrammetry and Remote Sensing, vol. 185, pp. 129-145. Land surface phenology (LSP) plays a critical role in the regulation of photosynthesis, evapotranspiration, and energy fluxes. Significant progress has been made in extracting LSP information over large areas using satellite data, yet LSP retrievals remain a challenge over vast arid and semi-arid ecosystems because of sparse greenness, high variability and the lack of distinct annual patterns; for example, the MODerate Imaging Spectrometer (MODIS) Land Cover Dynamics Product MCD12Q2 that provides LSP metrics globally often failed to provide LSP information in these ecosystems. In this study, we used a modified threshold algorithm to extract LSP timing metrics, including the start, peak, and end of growing seasons, using the 16-day composite Enhanced Vegetation Index (EVI) time series from MODIS data. We applied this regionally customized algorithm across all arid and semi-arid climate regions of Australia (75% of the continental land area) encompassing shrublands, grasslands, savannas, woodlands, and croplands, extracting LSP metrics annually from 2003 to 2018, with up to two (phenology) seasons accounted for in each year. Our algorithm yielded an average of 64.9% successful rate of retrieval (proportion of pixels with retrieved LSP metrics) across 16 years in Arid and Semi-arid AUStralia (AS-AUS), which was a significant increase compared to the 14.5% rate of retrieval yielded in our study area by the global product and the major cause of the different performances between these two approaches was the different EVI amplitude restrictions utilized to avoid spurious peaks (i.e. EVI amplitude ≥ 0.1 used by the global product and peak EVI ≥ time series average EVI used by our algorithm). Gross primary productivity (GPP) measurements at OzFlux eddy covariance (EC) tower sites were used to cross-compare with the presence/absence of growing seasons detected by our algorithm, and 97% of our retrieved seasons matched with those extracted using EC data. Prelimin... Xie, Q, Huete, A, Hall, CC, Medlyn, BE, Power, SA, Davies, JM, Medek, DE & Beggs, PJ 2022, 'Satellite-observed shifts in C3/C4 abundance in Australian grasslands are associated with rainfall patterns', Remote Sensing of Environment, vol. 273, pp. 112983-112983. Species composition is a key determinant of grassland ecosystem function and resilience. Climate change is predicted to alter the distribution of cool season (C3) and warm season (C4) grasses, however, the lack of spatial distributions and temporal variations of grass functional type information severely limits our understanding of climate impacts on grasslands. This study classified C3 and C4 grasses per pixel according to the peak of growing season generated from Enhanced Vegetation Index time series. From 2003 to 2017, the C3-C4 composition of Australian rain-fed grasslands and pastures was mapped at 500 m resolution on an annual basis across a wide geographical range (10°S – 45°S), and revealed extreme inter-annual fluctuations. Over the 15-year period, the satellite-derived ratio of C4 to C3 grasses significantly increased (p < 0.05), indicating a long-term shift in community composition that was confirmed with 182,911 Atlas of Living Australia ground observations. The most pronounced changes occurred in mid-latitude transitional areas where C3 and C4 grasses co-dominate. Our climate analysis indicated the inter-annual fluctuations of C4/C3 grass ratios were significantly associated (p < 0.05) with warm/cool season rainfall ratios, and not with temperature or annual rainfall. This suggests that an increase in the warm/cool season rainfall ratio favors C4 grasses and a decrease in the warm/cool season rainfall ratio favors C3 grasses. Our findings reveal spatially-detailed dynamics of grasslands and demonstrate large-scale grassland compositional changes over 15 years. The grass composition maps should help improve ecological forecasting of grass distributions and enable researches on grassland ecosystem responses to climate change that are relevant to both adaptation of rangeland agricultural and fire management practices. Our study should also help predict grass distribution under future climate conditions, and assist in the accurate modelling of ... Xie, T, Dickson, K-A, Yee, C, Ma, Y, Ford, CE, Bowden, NA & Marsh, DJ 2022, 'Targeting Homologous Recombination Deficiency in Ovarian Cancer with PARP Inhibitors: Synthetic Lethal Strategies That Impact Overall Survival', Cancers, vol. 14, no. 19, pp. 4621-4621. Xing, D, Dong, C, Li, Z, Liu, Y, Wang, B, Hua, Q & Tang, J 2022, 'Preparation and Characterization of Sodium Sulfate Decahydrate–Sodium Acetate Trihydrate Shape-Stabilized Phase Change Materials', Energy & Fuels, vol. 36, no. 9, pp. 4947-4956. Xirocostas, ZA, Debono, SA, Slavich, E & Moles, AT 2022, 'The ZAX Herbivory Trainer—Free software for training researchers to visually estimate leaf damage', Methods in Ecology and Evolution, vol. 13, no. 3, pp. 596-602. Xu, J, Fang, H, Su, Y, Kang, Y, Xu, D, Cheng, YY, Nie, Y, Wang, H, Liu, T & Song, K 2022, 'A 3D bioprinted decellularized extracellular matrix/gelatin/quaternized chitosan scaffold assembling with poly(ionic liquid)s for skin tissue engineering', International Journal of Biological Macromolecules, vol. 220, pp. 1253-1266. Currently, a suitable bioink for 3D bioprinting and capable of mimicking the microenvironment of native skin and preventing bacterial infection remains a major challenge in skin tissue engineering. In this study, we prepared a tissue-specific extracellular matrix-based bioink, and dECM/Gel/QCS (dGQ) 3D scaffold assembling with poly(ionic liquid)s (PILs) (dGQP) was obtained by an extrusion 3D bioprinting technology and dynamic hydrogen bonding method. The morphologies, mechanical properties, porosity, hydrophilicity, biodegradation, hemostatic effect, antibacterial ability, and biocompatibility of the hybrid scaffolds were characterized and evaluated. Results showed that the rapid release (2 h) of PILs on the dGQP scaffold can quickly kill gram-negative (E. coli) and gram-positive (S. aureus) bacteria with almost 100 % antibacterial activity and maintained a stable sterile environment for a long time (7 d), which was superior to the dGQ scaffold. The hemostasis and hemolysis test showed that the dGQP scaffold had a good hemostatic effect and excellent hemocompatibility. In vitro cytocompatibility studies showed that although the cell growth on dGQP scaffold was slow in the early stage, the cells proliferated rapidly since day 4 and had high ECM secretion at day 7. Overall, this advanced dGQP scaffold has a considerable potential to be applied in skin tissue engineering. Xu, J, Jin, Y, Liu, K, Lyu, N, Zhang, Z, Sun, B, Jin, Q, Lu, H, Tian, H, Guo, X, Shanmukaraj, D, Wu, H, Li, M, Armand, M & Wang, G 2022, 'A green and sustainable strategy toward lithium resources recycling from spent batteries', Science Advances, vol. 8, no. 40, p. eabq7948. Xu, J, Lv, W, Yang, W, Jin, Y, Jin, Q, Sun, B, Zhang, Z, Wang, T, Zheng, L, Shi, X, Sun, B & Wang, G 2022, 'In Situ Construction of Protective Films on Zn Metal Anodes via Natural Protein Additives Enabling High-Performance Zinc Ion Batteries', ACS Nano, vol. 16, no. 7, pp. 11392-11404. The strong activity of water molecules causes a series of parasitic side reactions on Zn anodes in the aqueous electrolytes. Herein, we introduce silk fibroin (SF) as a multifunctional electrolyte additive for aqueous zinc-ion (Zn-ion) batteries. The secondary structure transformation of SF molecules from α-helices to random coils in the aqueous electrolytes allows them to break the hydrogen bond network among free water molecules and participate in Zn2+ ion solvation structure. The SF molecules released from the [Zn(H2O)4(SF)]2+ solvation sheath appear to be gradually adsorbed on the surface of Zn anodes and in situ form a hydrostable and self-healable protective film. This SF-based protective film not only shows strong Zn2+ ion affinity to promote homogeneous Zn deposition but also has good insulating behavior to suppress parasitic reactions. Benefiting from these multifunctional advantages, the cycle life of the Zn||Zn symmetric cells reaches over 1600 h in SF-containing ZnSO4 electrolytes. In addition, by adopting a potassium vanadate cathode, the full cell shows excellent cycling stability for 1000 cycles at 3 A g-1. The in situ construction of a protective film on the Zn anode from natural protein molecules provides an effective strategy to achieve high-performance Zn metal anodes for Zn-ion batteries. Xu, J, Xu, L, Zhang, Z, Sun, B, Jin, Y, Jin, Q, Liu, H & Wang, G 2022, 'Heterostructure ZnSe-CoSe2 embedded with yolk-shell conductive dodecahedral as Two-in-one hosts for cathode and anode protection of Lithium–Sulfur full batteries', Energy Storage Materials, vol. 47, pp. 223-234. Simultaneously realizing the cathode and anode protection is critical for developing practical lithium sulfur (Li-S) batteries. Currently, many efforts have been devoted to solving problems related to either shuttle effect on sulfur cathode or dendrite growth on lithium anode. However, dual side protection is rarely reported. Herein, we rationally designed and synthesized yolk-shell nitrogen doped carbon frameworks embedded with heterostructures ZnSe-CoSe2 (ZnSe-CoSe2@NC), working as “two-in-one” hosts for both the sulfur cathode and lithium anode protection. As an anode host, the in situ formed Li2Se phase contributes to the Li+ transfer. Co and Zn guides a homogenous growth of Li within the 3D framework, thus effectively suppressing Li dendrite growth. Meanwhile, the heterostructure ZnSe-CoSe2 endows the cathode host with superior electronic conductivity, strong polysulfide chemisorption and efficient catalytic activity for polysulfide redox when compared with single metal selenides. Combined with these advantages, this Li-S full cell exhibits ultralong cycle life over 1000 cycles at 2 C. Even with a high sulfur loading (6.08 mg cm−2) and lean electrolyte (4.1 µL mg−1), the full cell achieves a high areal capacity of 4.16 mA h cm−2 after 100 cycles at 0.2 C. This work not only provides a new approach for the structure design of Li-S full battery, but also improves the utilization of active electrode materials. Xu, X, Wang, C, Fronzi, M, Liu, X & Bi, L 2022, 'Correction to: Modification of a first‑generation solid oxide fuel cell cathode with Co3O4 nanocubes having selectively exposed crystal planes', Materials for Renewable and Sustainable Energy, vol. 11, no. 3, pp. 299-299. Xu, Z, Hu, D, Luu, LDW, Octavia, S, Keil, AD, Sintchenko, V, Tanaka, MM, Mooi, FR, Robson, J & Lan, R 2022, 'Genomic dissection of the microevolution of Australian epidemic Bordetella pertussis', Emerging Microbes & Infections, vol. 11, no. 1, pp. 1460-1473. Yam, JKH, Aung, TT, Chua, SL, Cheng, Y, Kohli, GS, Zhou, J, Constancias, F, Liu, Y, Cai, Z, Salido, MMS, Drautz-Moses, DI, Rice, SA, Schuster, SC, Boo, ZZ, Wu, B, Kjelleberg, S, Tolker-Nielsen, T, Lakshminarayanan, R, Beuerman, RW, Yang, L & Givskov, M 2022, 'Elevated c-di-GMP Levels and Expression of the Type III Secretion System Promote Corneal Infection by Pseudomonas aeruginosa', Infection and Immunity, vol. 90, no. 8, pp. 1-17. Yamamura, K, Zhu, L, Irvine, CP, Scott, JA, Singh, M, Jallandhra, A, Bansal, V, Phillips, MR & Ton-That, C 2022, 'Defect Compensation in Nitrogen-Doped β-Ga2O3 Nanowires: Implications for Bipolar Nanoscale Devices', ACS Applied Nano Materials, vol. 5, no. 9, pp. 12087-12094. Nitrogen (N) is a promising candidate currently being pursued for p-type doping in Ga2O3. In this work, the results of detailed investigations into N-doped β-Ga2O3nanowires using microstructural, chemical, and optical analyses are described. Monoclinic β-Ga2O3nanowires are grown by chemical vapor deposition using a metallic gallium (Ga) precursor and subsequently doped with N by remote plasma by exploiting their nanoscale cross sections and large surface-to-volume ratios. The N incorporation into β-Ga2O3is confirmed by X-ray absorption near-edge and Raman spectroscopies without changes in the nanowire morphology. N is found to exist mainly as molecular N2and N-O chemical states, but a significant portion of N substitutes on oxygen (O) sites. Concurrent temperature-resolved cathodoluminescence measurements of the undoped and N-doped β-Ga2O3are used to track the temperature dependences of their intrinsic ultraviolet (UV) luminescence and defect-related visible bands from 80 to 480 K. The blue and green bands increase in intensity relative to the UV after N doping; however, their intensity variations with temperature are found to be identical for the undoped and N-doped β-Ga2O3, indicating that these bands originate from existing recombination pathways in Ga2O3rather than from radiative N-related centers. The enhancement in defect-related luminescence in N-doped β-Ga2O3is explained by an increase in the concentration of O vacancies as a result of the compensation of NOacceptors. Yan, J, Han, VX, Heng, B, Guillemin, GJ, Bandodkar, S & Dale, RC 2022, 'Development of a translational inflammation panel for the quantification of cerebrospinal fluid Pterin, Tryptophan-Kynurenine and Nitric oxide pathway metabolites', eBioMedicine, vol. 77, pp. 103917-103917. Yan, J, Kothur, K, Innes, EA, Han, VX, Jones, HF, Patel, S, Tsang, E, Webster, R, Gupta, S, Troedson, C, Menezes, MP, Antony, J, Ardern-Holmes, S, Tantsis, E, Mohammad, S, Wienholt, L, Pires, AS, Heng, B, Guillemin, GJ, Guller, A, Gill, D, Bandodkar, S & Dale, RC 2022, 'Decreased cerebrospinal fluid kynurenic acid in epileptic spasms: A biomarker of response to corticosteroids', eBioMedicine, vol. 84, pp. 104280-104280. Yang, T, Mendelson, N, Li, C, Gottscholl, A, Scott, J, Kianinia, M, Dyakonov, V, Toth, M & Aharonovich, I 2022, 'Spin defects in hexagonal boron nitride for strain sensing on nanopillar arrays', Nanoscale, vol. 14, no. 13, pp. 5239-5244. Yang, X, Leys, J, Gray, J & Zhang, M 2022, 'Hillslope erosion improvement targets: Towards sustainable land management across New South Wales, Australia', CATENA, vol. 211, pp. 105956-105956. Hillslope erosion, including sheet and rill erosion, is the dominant form of erosion in Australia and many parts of the world. Hillslope erosion improvement (HEI) targets are necessary for the evaluation of natural resource condition and sustainable land use and land management practices. The tolerable soil loss concept has been widely applied to agricultural lands for setting soil erosion targets. It is a static target that is difficult to apply to diverse land uses and soil conditions. In this study, we developed a new approach for setting HEI resource condition targets by considering seasonal erosion levels over a large climate gradient and range of land management practices across New South Wales (NSW), Australia. A 20-year fractional vegetation cover and rainfall erosivity time-series have been used to estimate hillslope erosion rates and assign monthly and annual HEI targets across NSW. To assist with land management action target, monthly vegetation cover levels have been set to meet the HEI targets on a pixel-by-pixel (100 m) basis. We further assessed the HEI targets against land and soil capability classes and their spatial and temporal variation across local land service regions. The findings can help identify the locations and periods of time with hillslope erosion exceeding a desirable threshold level and indicate management actions that might be required to improve the soil condition over areas of concern. The processes are fully automated in a geographic information system (GIS) environment, thus providing a useful tool to determine HEI targets for sustainable soil and land management at any location and period. The methods are globally portable as the input datasets are widely available. Yang, X, Wang, X, He, Q, Yu, W, Wang, L, Zhang, C, Wang, T, Fu, S, Yun, K & Wei, Z 2022, 'Rat-modelled Distribution of Methcathinone and Its Metabolites', Forensic Science and Technology, vol. 47, no. 5, pp. 497-505. An intraperitoneal infection model was here established about methcathinone with rat as the experimental animal, and the distribution of both the drug itself and its metabolites was observed in the rat tissues. SD rats, the selected experimental animal, were divided into three groups that were injected of methcathinone via the intraperitoneal route under the respective dose of 7.6 mg/kg, 15.2 mg/kg and 22.8 mg/kg and successively monitored of their poisoning symptoms. The rats were put to death at 5 min, 15 min and 30 min after drug injection, with their heart, liver, spleen, lung, kidney, brain, stomach, muscle, testicle and heart blood being collected immediately. From the extractions of the above rat tissues, HPLC-MS/MS was to detect the distributed methcathinone and its metabolites: cathinone, ephedrine and pseudoephedrine. Few effects were found of dose on distribution patterns of methcathinone, cathinone, ephedrine and pseudoephedrine among the rat tissues. Kidney was shown of highest concentration for the four tested chemical substances. Within same tissue, methcathinone was always demonstrating highest concentration, leaving cathinone, ephedrine and pseudoephedrine being as the sequential followers. Both methcathinone and cathinone were exceeded over the limit of quantification with the tested blood at each dose, contrasting to ephedrine and pseudoephedrine being under the detection limit any time. The distributed methcathinone was sequentially concentrated as 15 min> 5 min> 30 min, the three time points for rat execution. Nevertheless, cathinone was shown concentrated at the order of 30 min> 15 min> 5 min. Ephedrine and pseudoephedrine were found of mainly distributing in kidney, liver and lungs. Therefore, both methcathinone and its metabolites were distributed in imbalance among the rat tissues. Kidney was of harboring concentration-highest methcathinone, eligible as the sample for forensic identification of abusing methcathinone or relevant ... Yao, W, Hu, S, Jia, F, Reimers, JR, Wang, Y, Singh, DJ & Ren, W 2022, 'Lattice strain and band overlap of the thermoelectric composite Mg2Si1-xSnx solid solutions show enhanced thermoelectric performance when the Sn mole fraction x is approximately x=0.7. This has been discussed in terms of complexity of the electronic structure arising from the crossover of two bottom conduction bands, but direct detailed understanding of the origins and the precise nature of this band convergence is limited. Here, we report first-principles calculations of the band edge changes analyzed by band unfolding and crystal orbital Hamilton population techniques. We find that strain is particularly important at this crossing. Mg2Si and Mg2Sn show opposite trends in the conduction band edge shifts leading to a band crossover at x∼0.625. However, there are also important effects due to disorder. Transport calculations show that enhancement of the figure of merit ZT value owes to the combined effects of lattice strain, band edge overlap, composition change, and disorder. Ye, Z, Silva, DM, Traini, D, Young, P, Cheng, S & Ong, HX 2022, 'An adaptable microreactor to investigate the influence of interfaces on Pseudomonas aeruginosa biofilm growth', Applied Microbiology and Biotechnology, vol. 106, no. 3, pp. 1067-1077. Yee, C, Dickson, K-A, Muntasir, MN, Ma, Y & Marsh, DJ 2022, 'Three-Dimensional Modelling of Ovarian Cancer: From Cell Lines to Organoids for Discovery and Personalized Medicine', Frontiers in Bioengineering and Biotechnology, vol. 10. Yi, C, Wang, Q, Qu, Y, Niu, J, Oliver, BG & Chen, H 2022, 'In-utero exposure to air pollution and early-life neural development and cognition', Ecotoxicology and Environmental Safety, vol. 238, pp. 113589-113589. Yi, GY, He, W & Carroll, RJ 2022, 'Feature screening with large‐scale and high‐dimensional survival data', Biometrics, vol. 78, no. 3, pp. 894-907. Yonathan, K, Mann, R, Mahbub, KR & Gunawan, C 2022, 'The impact of silver nanoparticles on microbial communities and antibiotic resistance determinants in the environment', Environmental Pollution, vol. 293, pp. 118506-118506. Nanosilver (NAg) is currently one of the major alternative antimicrobials to control microorganisms. With its broad-spectrum efficacy and lucrative commercial values, NAg has been used in medical devices and increasingly, in consumer products and appliances. This widespread use has inevitably led to the release and accumulation of the nanoparticle in water and sediment, in soil and even, wastewater treatment plants (WWTPs). This Article describes the physical and chemical transformations of NAg as well as the impact of the nanoparticle on microbial communities in different environmental settings; how the nanoparticle shifts not only the diversity and abundance of microbes, including those that are important in nitrogen cycles and decomposition of organic matters, but also their associated genes and in turn, the key metabolic processes. Current findings on the microbiological activity of the leached soluble silver, solid silver particulates and their respective transformed products, which underpin the mechanism of the nanoparticle toxicity in environmental microbes, is critically discussed. The Article also addresses the emerging evidence of silver-driven co-selection of antibiotic resistance determinants. The mechanism has been linked to the increasing pools of many antibiotic resistance genes already detected in samples from different environmental settings, which could ultimately find their ways to animals and human. The realized ecological impact of NAg calls for more judicial use of the nanoparticle. The generated knowledge can inform strategies for a better 'risks versus benefits' assessment of NAg applications, including the disposal stage. York, E, McNaughton, DA, Roseblade, A, Cranfield, CG, Gale, PA & Rawling, T 2022, 'Structure–Activity Relationship and Mechanistic Studies of Bisaryl Urea Anticancer Agents Indicate Mitochondrial Uncoupling by a Fatty Acid-Activated Mechanism', ACS Chemical Biology, vol. 17, no. 8, pp. 2065-2073. Targeting the cancer cell mitochondrion is a promising approach for developing novel anticancer agents. The experimental anticancer agent N,N'-bis(3,5-dichlorophenyl)urea (SR4) induces apoptotic cell death in several cancer cell lines by uncoupling mitochondrial oxidative phosphorylation (OxPhos) using a protein-free mechanism. However, the precise mechanism by which SR4 depolarizes mitochondria is unclear because SR4 lacks an acidic functional group typically found in protein-independent uncouplers. Recently, it was shown that structurally related thioureas can facilitate proton transport across lipid bilayers by a fatty acid-activated mechanism, in which the fatty acid acts as the site of protonation/deprotonation and the thiourea acts as an anion transporter that shuttles deprotonated fatty acids across the phospholipid bilayer to enable proton leak. In this paper, we show that SR4-mediated proton transport is enhanced by the presence of free fatty acids in the lipid bilayer, indicating that SR4 uncouples mitochondria through the fatty acid-activated mechanism. This mechanistic insight was used to develop a library of substituted bisaryl ureas for structure-activity relationship studies and subsequent cell testing. It was found that lipophilic electron-withdrawing groups on bisaryl ureas enhanced electrogenic proton transport via the fatty acid-activated mechanism and had the capacity to depolarize mitochondria and reduce the viability of MDA-MB-231 breast cancer cells. The most active compound in the series reduced cell viability with greater potency than SR4 and was more effective at inhibiting adenosine triphosphate production. Yousaf, M, Naseer, U, Ali, I, Li, Y, Aftab, W, Mahmood, A, Mahmood, N, Gao, P, Jiang, Y & Guo, S 2022, 'Role of binary metal chalcogenides in extending the limits of energy storage systems: Challenges and possible solutions', Science China Materials, vol. 65, no. 3, pp. 559-592. Yousaf, M, Naseer, U, Imran, A, Li, Y, Aftab, W, Mahmood, A, Mahmood, N, Zhang, X, Gao, P, Lu, Y, Guo, S, Pan, H & Jiang, Y 2022, 'Visualization of battery materials and their interfaces/interphases using cryogenic electron microscopy', Materials Today, vol. 58, pp. 238-274. Yu, G, Su, Y, Guo, C, Yi, C, Yu, B, Chen, H, Cui, Y, Wang, X, Wang, Y, Chen, X, Wang, S, Wang, Q, Chen, X, Hu, X, Mei, F, Verkhratsky, A, Xiao, L & Niu, J 2022, 'Pathological oligodendrocyte precursor cells revealed in human schizophrenic brains and trigger schizophrenia-like behaviors and synaptic defects in genetic animal model', Molecular Psychiatry, vol. 27, no. 12, pp. 5154-5166. Zaidan, I, Tavares, LP, Sugimoto, MA, Lima, KM, Negreiros-Lima, GL, Teixeira, LCR, Miranda, TC, Valiate, BVS, Cramer, A, Vago, JP, Campolina-Silva, GH, Souza, JAM, Grossi, LC, Pinho, V, Campagnole-Santos, MJ, Santos, RAS, Teixeira, MM, Galvão, I & Sousa, LP 2022, 'Angiotensin-(1-7)/MasR axis promotes migration of monocytes/macrophages with a regulatory phenotype to perform phagocytosis and efferocytosis', JCI Insight, vol. 7, no. 1. Zakria, M, Rogers, DJ, Scola, J, Zhu, L, Lockrey, M, Bove, P, Sandana, EV, Teherani, FH, Phillips, MR & Ton-That, C 2022, 'Two-dimensional confinement of excitons at the interface in nonpolar MgZnO/ZnO heterostructures', Physical Review Materials, vol. 6, no. 3. We report on the polarity-dependent excitonic emission at the interface in MgZnO/ZnO heterostructures grown on both polar and nonpolar ZnO single-crystal substrates. Structural and morphological analyses confirm that the heterostructures grow homoepitaxially on nonpolar m-plane and a-plane crystal substrates. The nonpolar heterostructures are investigated by depth-resolved cathodoluminescence spectroscopy revealing an excitonic interface emission centered at 3.12 eV, identified as the H-band signature of indirect excitons. These results reveal the formation of robust indirect excitons confined at the MgZnO/ZnO interface due to the presence of an epitaxially strained interfacial layer near the interface in the MgZnO, which is confirmed by high-order X-ray diffraction. It is also found that the H-band emission originates from the self-absorption of the ZnO free exciton emission in the proximity of the interface. Temperature-dependent studies of the H band yields a thermal activation energy of 47 meV for the indirect exciton in the nonpolar heterojunctions. This activation energy is the largest among all free and bound excitons in ZnO and is much higher than the values found in AlGaN/GaN and MgZnO/ZnO/sapphire hetrostructures. Our findings indicate that the optical properties of nonpolar heterostructures are strongly influenced by the piezoelectric effect. Zalogina, A, Tonkaev, P, Tripathi, A, Lee, H-C, Carletti, L, Park, H-G, Kruk, SS & Kivshar, Y 2022, 'Enhanced Five-Photon Photoluminescence in Subwavelength AlGaAs Resonators', Nano Letters, vol. 22, no. 10, pp. 4200-4206. Zeng, HZ, Ngyuen, MAP, Ai, X, Bennet, A, Solntsev, AS, Laucht, A, Al-Juboori, A, Toth, M, Mildren, RP, Malaney, R & Aharonovich, I 2022, 'Integrated room temperature single-photon source for quantum key distribution: publisher’s note', Optics Letters, vol. 47, no. 9, pp. 2161-2161. Zeng, HZJ, Ngyuen, MAP, Ai, X, Bennet, A, Solntsev, AS, Laucht, A, Al-Juboori, A, Toth, M, Mildren, RP, Malaney, R & Aharonovich, I 2022, 'Integrated room temperature single-photon source for quantum key distribution', Optics Letters, vol. 47, no. 7, pp. 1673-1673. Zeng, Y, Hao, D, Huete, A, Dechant, B, Berry, J, Chen, JM, Joiner, J, Frankenberg, C, Bond-Lamberty, B, Ryu, Y, Xiao, J, Asrar, GR & Chen, M 2022, 'Optical vegetation indices for monitoring terrestrial ecosystems globally', Nature Reviews Earth & Environment, vol. 3, no. 7, pp. 477-493. Vegetation indices (VIs), which describe remotely sensed vegetation properties such as photosynthetic activity and canopy structure, are widely used to study vegetation dynamics across scales. However, VI-based results can vary between indices, sensors, quality control measures, compositing algorithms, and atmospheric and sun–target–sensor geometry corrections. These variations make it difficult to draw robust conclusions about ecosystem change and highlight the need for consistent VI application and verification. In this Technical Review, we summarize the history and ecological applications of VIs and the linkages and inconsistencies between them. VIs have been used since the early 1970s and have evolved rapidly with the emergence of new satellite sensors with more spectral channels, new scientific demands and advances in spectroscopy. When choosing VIs, the spectral sensitivity and features of VIs and their suitability for target application should be considered. During data analyses, steps must be taken to minimize the impact of artefacts, VI results should be verified with in situ data when possible and conclusions should be based on multiple sets of indicators. Next-generation VIs with higher signal-to-noise ratios and fewer artefacts will be possible with new satellite missions and integration with emerging vegetation metrics such as solar-induced chlorophyll fluorescence, providing opportunities for studying terrestrial ecosystems globally. Zhang, H, Li, J, Liu, Q, Lin, S, Huete, A, Liu, L, Croft, H, Clevers, JGPW, Zeng, Y, Wang, X, Gu, C, Zhang, Z, Zhao, J, Dong, Y, Mumtaz, F & Yu, W 2022, 'A novel red‐edge spectral index for retrieving the leaf chlorophyll content', Methods in Ecology and Evolution, vol. 13, no. 12, pp. 2771-2787. Zhang, J, Zhao, Y, Sun, B, Xie, Y, Tkacheva, A, Qiu, F, He, P, Zhou, H, Yan, K, Guo, X, Wang, S, McDonagh, AM, Peng, Z, Lu, J & Wang, G 2022, 'A long-life lithium-oxygen battery via a molecular quenching/mediating mechanism', Science Advances, vol. 8, no. 3, p. eabm1899. Zhang, K, Liu, J, Liu, Y, Zhang, P & Carroll, RJ 2022, 'Bayesian adjustment for measurement error in an offset variable in a Poisson regression model', Statistical Modelling, vol. 22, no. 6, pp. 509-526. Zhang, L, Cao, C, Kaushik, N, Lai, RY, Liao, J, Wang, G, Ariotti, N, Jin, D & Stenzel, MH 2022, 'Controlling the Biological Behaviors of Polymer-Coated Upconverting Nanoparticles by Adjusting the Linker Length of Estrone Ligands', Biomacromolecules, vol. 23, no. 6, pp. 2572-2585. The estrone ligand is used for modifying nanoparticle surfaces to improve their targeting effect on cancer cell lines. However, to date, there is no common agreement on the ideal linker length to be used for the optimum targeting performance. In this study, we aimed to investigate the impact of poly(poly ethylene glycol methyl ether methacrylate) (PPEGMEMA) linker length on the cellular uptake behavior of polymer-coated upconverting nanoparticles (UCNPs). Different triblock terpolymers, poly(poly (ethylene glycol) methyl ether methacrylate)-block-polymethacrylic acid-block-polyethylene glycol methacrylate phosphate (PPEGMEMAx-b-PMAAy-b-PEGMP3: x = 7, 15, 33, and 80; y = 16, 20, 18, and 18), were synthesized with different polymer linker chain lengths between the surface and the targeting ligand by reversible addition-fragmentation chain transfer polymerization. The estrone ligand was attached to the polymer via specific terminal conjugation. The cellular association of polymer-coated UCNPs with linker chain lengths was evaluated in MCF-7 cells by flow cytometry. Our results showed that the bioactivity of ligand modification is dependent on the length of the polymer linker. The shortest polymer PPEGMEMA7-b-PMAA16-b-PEGMP3 with estrone at the end of the polymer chain was found to have the best cellular association behavior in the estrogen receptor (ER)α-positive expression cell line MCF-7. Additionally, the anticancer drug doxorubicin•HCl was encapsulated in the nanocarrier to evaluate the 2D and 3D cytotoxicity. The results showed that estrone modification could efficiently improve the cellular uptake in ERα-positive expression cell lines and in 3D spheroid models. Zhang, L, Hou, S, Wang, T, Liu, S, Gao, X, Wang, C & Wang, G 2022, 'Recent Advances in Application of Graphitic Carbon Nitride‐Based Catalysts for Photocatalytic Nitrogen Fixation', Small, vol. 18, no. 28, pp. e2202252-2202252. Zhang, L, Rath, EM & Cheng, YY 2022, 'The Use of Epigenetic Biomarkers as Diagnostic and Therapeutic Options', Epigenomes, vol. 6, no. 4, pp. 30-30. Zhang, M, Viscarra Rossel, RA, Zhu, Q, Leys, J, Gray, JM, Yu, Q & Yang, X 2022, 'Dynamic Modelling of Water and Wind Erosion in Australia over the Past Two Decades', Remote Sensing, vol. 14, no. 21, pp. 5437-5437. Zhang, M, Yang, X, Cleverly, J, Huete, A, Zhang, H & Yu, Q 2022, 'Heat wave tracker: A multi-method, multi-source heat wave measurement toolkit based on Google Earth Engine', Environmental Modelling & Software, vol. 147, pp. 105255-105255. Under ongoing global warming due to climate change, heat waves in Australia are expected to become more frequent and severe. Extreme heat waves have devastating impacts on both terrestrial and marine ecosystems. A multi-characteristic heat wave framework is used to estimate historical and future projected heat waves across Australia. A Google Earth Engine-based toolkit named heat wave tracker (HWT) is developed, which can be used for dynamic visualization, extraction, and processing of complex heat wave events. The toolkit exploits the public long-term high-resolution climate datasets to developed nine heat wave datasets across Australia for extreme heat wave value analysis. To examine climate change on heat waves and how they vary in time and space, we also explore the probability and return periods of extreme heat waves over a period of 100 years. The datasets, toolkit and findings we developed contribute to global studies on heat waves under accelerated global warming. Zhang, Q, Liao, J, Huang, Q, Lai, N, Zhang, B, Wen, X, Yang, J, Yang, Y, Wang, J, Zhang, G, Wang, C & Wang, R 2022, 'Regulated broadband visible emission of Bi ions-doped borosilicate glass', Ceramics International, vol. 48, no. 22, pp. 34046-34052. Zhang, S, Zhang, X, Deng, K, Wang, C, Wood, LG, Wan, H, Liu, L, Wang, J, Zhang, L, Liu, Y, Cheng, G, Gibson, PG, Oliver, BG, Luo, F, McDonald, VM, Li, W & Wang, G 2022, 'Reduced Skeletal Muscle Mass Is Associated with an Increased Risk of Asthma Control and Exacerbation', Journal of Clinical Medicine, vol. 11, no. 23, pp. 7241-7241. Zhang, W, Liu, T, Brown, A, Ueland, M, Forbes, SL & Su, SW 2022, 'The Use of Electronic Nose for the Classification of Blended and Single Malt Scotch Whisky', IEEE Sensors Journal, vol. 22, no. 7, pp. 7015-7021. As with any profitable industry, the whisky market is subject to fraudulent activity, including adulteration. An expert can identify the differences between whiskies, but it is difficult for the majority of consumers to differentiate fraudulent beverages. Complex chemical and analytical analyses have been able to detect the differences between whiskies; however, this type of analysis is time-consuming, complex, requires trained professionals, and can only be conducted in the laboratory. A rapid and real-time assessment of whisky quality could prove beneficial to wholesalers and consumers. The odour of whiskies can be used to identify their brands, regions and styles, as thus has the potential for quality assessment and fraudulent detection. One type of technology used for real-time odour analysis is an electronic nose (e-nose). This study investigates the capability of a new e-nose prototype (called NOS.E) developed by our team to identify the differences between six whiskies with respect to their brand names, regions, and styles. This study investigates the capability of a new e-nose prototype (called NOS.E) developed by our team in identifying the differences among whiskies. Ensemble of several classifiers is adopted to improve the classification accuracy of the system. The proposed e-nose solution was verified by a field testing displayed at the CEBIT Australia 2019 trade show, by reaching an accuracy of 96.15%, 100%, and 92.31% in brand name, region, and style classification, respectively. Confirmation of the NOS.E findings was further carried out using comprehensive two-dimensional gas chromatography coupled with time-of-flight mass spectrometry (GC $\times $ GC-TOFMS). Zhang, Y, Almazi, JG, Ong, HX, Johansen, MD, Ledger, S, Traini, D, Hansbro, PM, Kelleher, AD & Ahlenstiel, CL 2022, 'Nanoparticle Delivery Platforms for RNAi Therapeutics Targeting COVID-19 Disease in the Respiratory Tract', International Journal of Molecular Sciences, vol. 23, no. 5, pp. 2408-2408. Zhang, Y, Chen, P, Wang, T, Su, D & Wang, C 2022, 'Development of Small‐Scale Monitoring and Modeling Strategies for Safe Lithium‐Ion Batteries', Batteries & Supercaps, vol. 5, no. 2. Zhang, Y, Silva, DM, Young, P, Traini, D, Li, M, Ong, HX & Cheng, S 2022, 'Understanding the effects of aerodynamic and hydrodynamic shear forces on Pseudomonas aeruginosa biofilm growth', Biotechnology and Bioengineering, vol. 119, no. 6, pp. 1483-1497. Zhang, Z, Mahmud, MAP & Kouzani, AZ 2022, 'FitNN: A Low-Resource FPGA-Based CNN Accelerator for Drones', IEEE Internet of Things Journal, vol. 9, no. 21, pp. 21357-21369. Zhang, Z, Mahmud, MAP & Kouzani, AZ 2022, 'Resource-constrained FPGA implementation of YOLOv2', Neural Computing and Applications, vol. 34, no. 19, pp. 16989-17006. Zhang, Z, Yang, X, Li, P, Wang, Y, Zhao, X, Safaei, J, Tian, H, Zhou, D, Li, B, Kang, F & Wang, G 2022, 'Biomimetic Dendrite‐Free Multivalent Metal Batteries', Advanced Materials, vol. 34, no. 47, pp. e2206970-2206970. Zhao, F, Liang, C, John Zaslawski, C & Cao, Z 2022, 'Effects of Qigong Therapy on the Anaerobic Threshold in Patients with Stable Coronary Artery Disease: A Randomized Controlled Trial', Evidence-Based Complementary and Alternative Medicine, vol. 2022, pp. 1-8. Zhao, H, Cun, Y, Bai, X, Xiao, D, Qiu, J, Song, Z, Liao, J & Yang, Z 2022, 'Entirely Reversible Photochromic Glass with High Coloration and Luminescence Contrast for 3D Optical Storage', ACS Energy Letters, vol. 7, no. 6, pp. 2060-2069. Zhao, K, Xu, X, Ren, W, Jin, D & Xi, P 2022, 'Two-photon MINFLUX with doubled localization precision', eLight, vol. 2, no. 1, p. 5. Zhao, N, Elshareef, H, Li, B, Wang, B, Jia, Z, Zhou, L, Liu, Y, Sultan, M, Dong, R & Zhou, Y 2022, 'The efforts of China to combat air pollution during the period of 2015–2018: A case study assessing the environmental, health and economic benefits in the Beijing-Tianjin-Hebei and surrounding “2 + 26” regions', Science of The Total Environment, vol. 853, pp. 158437-158437. Zhao, S, Liu, Z, Xie, G, Guo, Z, Wang, S, Zhou, J, Xie, X, Sun, B, Guo, S & Wang, G 2022, 'High-efficiency cathode potassium compensation and interfacial stability improvement enabled by dipotassium squarate for potassium-ion batteries', Energy & Environmental Science, vol. 15, no. 7, pp. 3015-3023. Zhao, Z, Tang, B, Yan, X, Wu, X, Li, Z, Gale, PA & Jiang, Y-B 2022, 'Crown ether-thiourea conjugates as ion transporters', Frontiers of Chemical Science and Engineering, vol. 16, no. 1, pp. 81-91. Na+, Cl− and K+ are the most abundant electrolytes present in biological fluids that are essential to the regulation of pH homeostasis, membrane potential and cell volume in living organisms. Herein, we report synthetic crown ether-thiourea conjugates as a cation/anion symporter, which can transport both Na+ and Cl− across lipid bilayers with relatively high transport activity. Surprisingly, the ion transport activities were diminished when high concentrations of K+ ions were present outside the vesicles. This unusual behavior resulted from the strong affinity of the transporters for K+ ions, which led to predominant partitioning of the transporters as the K+ complexes in the aqueous phase preventing the transporter incorporation into the membrane. Synthetic membrane transporters with Na+, Cl− and K+ transport capabilities may have potential biological and medicinal applications. [Figure not available: see fulltext.] Zhong, X, Zhang, L, van Wezel, GP, Vijgenboom, E & Claessen, D 2022, 'Role for a Lytic Polysaccharide Monooxygenase in Cell Wall Remodeling in Streptomyces coelicolor', mBio, vol. 13, no. 2, p. e0045622. Zhou, T, Li, X, Zhang, Q, Dong, S, Liu, H, Liu, Y, Chaves, AV, Ralph, PJ, Ruan, R & Wang, Q 2022, 'Ecotoxicological response of Spirulina platensis to coexisted copper and zinc in anaerobic digestion effluent', Science of The Total Environment, vol. 837, pp. 155874-155874. Copper ion (Cu2+) and zinc ion (Zn2+) are widely co-existent in anaerobic digestion effluent as typical contaminants. This work aims to explore how Cu2+-Zn2+ association affects physiological properties of S. platensis using Schlösser medium (SM) and sterilized anaerobic digestion effluent (SADE). Microalgae cells viability, biochemical properties, uptake of Cu2+ and Zn2+, and risk assessment associated with the biomass reuse as additives to pigs were comprehensively assessed. Biomass production ranged from 0.03 to 0.28 g/L in SM and 0.63 to 0.79 g/L in SADE due to the presence of Cu2+ and Zn2+. Peak value of chlorophyll-a and carotenoid content during the experiment decreased by 70-100% and 40-100% in SM, and by 70-77% and 30-55% in SADE. Crude protein level reduced by 4-41% in SM and by 65-75% in SADE. The reduction ratio of these compounds was positively related to the Cu2+ and Zn2+ concentrations. Maximum value of saturated and unsaturated fatty acids was both obtained at 0.3 Cu + 2.0 Zn (50.8% and 22.8%, respectively) and 25% SADE reactors (33.8% and 27.7%, respectively). Uptake of Cu in biomass was facilitated by Zn2+ concentration (> 4.0 mg/L). Risk of S. platensis biomass associated with Cu2+ was higher than Zn2+. S. platensis from SM (Cu2+ ≤ 0.3 mg/L and Zn2+ ≤ 4.0 mg/L) and diluted SADE (25% and 50% SADE) reactors could be used as feed additives without any risk (hazard index <1), which provides sufficient protein and fatty acids for pig consumption. These results revealed the promising application of using S. platensis for bioremediation of Cu2+ and Zn2+ in anaerobic digestion effluent and harvesting biomass for animal feed additives. Zhou, W, Li, A, Gale, PA & He, Q 2022, 'A highly selective superphane for ReO4− recognition and extraction', Cell Reports Physical Science, vol. 3, no. 5, pp. 100875-100875. Highly selective anion recognition and extraction is challenging and yet critical for removal of pollutants from the environment and the effective recovery of valuable chemicals from low-content (at sub-ppm or ppb level) sources. In this paper, we detail the gram-scale synthesis of a superphane 2, an anion receptor that selectively binds ReO4−. Superphane 2 can extract perrhenate from solid mixtures containing traces of ReO4− anion (as low as 200 ppb) and aqueous media with near 100% selectivity over large excesses of competing anions. Meanwhile, up to 99.99% of ReO4− can be separated from complex simulated aqueous waste streams containing ppm-level perrhenate via either liquid-liquid extraction or simple column adsorption. Importantly, after extraction or adsorption, superphane 2 can be recycled and reused by simple treatment with aqueous NaHCO3. Zhou, X, Wang, T, liu, H, Zhang, L, Zhang, C, Kong, N, Su, D & Wang, C 2022, 'Design of S-scheme heterojunction catalyst based on structural defects for photocatalytic oxidative desulfurization application', Journal of Photochemistry and Photobiology A: Chemistry, vol. 433, pp. 114162-114162. Carbon nitride (g-C3N4) is promising for many applications, but its photocatalytic activity is limited by weak visible light absorption and photogenerated carrier complexes. Herein, the thermally defective carbon nitride (d-C3N4) has a larger specific surface area and more reactive sites. d-C3N4 helped Ag3PO4 nanoparticles to be uniformly deposited on the surface of it and made it easier for particle dispersion. d-C3N4 and Ag3PO4 form an S-scheme heterojunction, facilitating the transfer and separation of photogenerated electrons and holes, and possessing high redox ability, which results in improved photocatalytic performance. The experimental results showed that the conversion of 10: 1 Ag3PO4/d-C3N4 for photocatalytic oxidative desulfurization (PODS) under visible light was as high as 92.5 % at 3 h, mainly due to the S-scheme heterojunction further promoting the transfer and separation of photogenerated carriers, suppressing the fast complexation and improving the efficiency of photocatalysis. In addition, the conversion mechanism of PODS was demonstrated using radical capture test, electron paramagnetic resonance spectrometer (EPR), and gas chromatography-mass spectrometry (GC–MS). This study helps researchers to understand the S-scheme heterojunctions constructed based on defects and provides new ideas for the design and application of photocatalysts. Zhou, X, Wang, T, Zhang, L, Che, S, Liu, H, Liu, S, Wang, C, Su, D & Teng, Z 2022, 'Highly efficient Ag2O/Na-g-C3N4 heterojunction for photocatalytic desulfurization of thiophene in fuel under ambient air conditions', Applied Catalysis B: Environmental, vol. 316, pp. 121614-121614. A composite photocatalyst of Ag2O and Na doped g-C3N4 (Ag2O/Na-CN) with high efficiency was investigated for photocatalytic oxidative desulfurization (PODS). The concentration and lifetime of carriers are increased with Na-CN. Under light conditions, it produces more charge carriers for the generation of radical species, such as superoxide radicals and holes. In addition, Na-CN and Ag2O form a p-n heterojunction, facilitating the transfer and separation of photogenerated electrons and holes, and increasing the concentration of holes on the valence band of Ag2O. The significantly improved charge separation alone with the higher carrier concentration of Ag2O/Na-CN makes the activation and oxidation of thiophene easier. Free radical capture experiments, electron paramagnetic resonance, and gas chromatography-mass spectrometry tests showed that holes, electrons, and superoxide radicals are the most critical active species in the PODS process, supporting the proposed PODS mechanism. Zinder, Y, Lazarev, A & Musatova, E 2022, 'Single Track Transportation in a Two-Machine Production System', IFAC-PapersOnLine, vol. 55, no. 10, pp. 2893-2897. Zograf, G, Koshelev, K, Zalogina, A, Korolev, V, Hollinger, R, Choi, D-Y, Zuerch, M, Spielmann, C, Luther-Davies, B, Kartashov, D, Makarov, SV, Kruk, SS & Kivshar, Y 2022, 'High-Harmonic Generation from Resonant Dielectric Metasurfaces Empowered by Bound States in the Continuum', ACS Photonics, vol. 9, no. 2, pp. 567-574. Zou, Y, Sun, X, Yang, Q, Zheng, M, Shimoni, O, Ruan, W, Wang, Y, Zhang, D, Yin, J, Huang, X, Tao, W, Park, JB, Liang, X-J, Leong, KW & Shi, B 2022, 'Blood-brain barrier–penetrating single CRISPR-Cas9 nanocapsules for effective and safe glioblastoma gene therapy', Science Advances, vol. 8, no. 16, p. eabm8011. Zuo, Y, Li, R, Zhang, Y, Bao, G, Le, Y & Yan, L 2022, 'Design, synthesis and antitumor activity of 5-trifluoromethylpyrimidine derivatives as EGFR inhibitors', Journal of Enzyme Inhibition and Medicinal Chemistry, vol. 37, no. 1, pp. 2742-2754. A new series of 5-trifluoromethylpyrimidine derivatives were designed and synthesised as EGFR inhibitors. Three tumour cells A549, MCF-7, PC-3 and EGFR kinase were employed to evaluate their biological activities. The results were shown that most of the target compounds existed excellent antitumor activities. In particular, the IC50 values of compound 9u (E)-3-((2-((4-(3-(3-fluorophenyl)acrylamido)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)amino)-N-methylthiophene-2-carboxamide against A549, MCF-7, PC-3 cells and EGFR kinase reached to 0.35 μM, 3.24 μM, 5.12 μM, and 0.091 μM, respectively. Additionally, further researches revealed that compound 9u could induce early apoptosis of A549 cells and arrest the cells in G2/M phase. Taken together, these findings indicated that compound 9u was potential for developing as antitumor reagent.
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Conferences
Armstrong, E, Coffin, J, Hersh, D, Katzenellenbogen, JM, Thompson, S, Flicker, L, McAllister, M, Cadilhac, D, Rai, T, Godecke, E, Hayward, C, Hankey, GJ, Drew, N, Lin, I, Woods, D & Ciccone, N 1970, 'Healing Right Way RCT: Novel interventions to enhance the cultural security of rehabilitation services for Aboriginal Australians with brain injury', INTERNATIONAL JOURNAL OF STROKE, SAGE PUBLICATIONS LTD, pp. 14-14.
Budden, K, Rehman, SF, Shukla, S, Bowerman, K, Donovan, C, Gomez, H, Alemao, C, Wood, L, Dennis, P, Hugenholtz, P, Wark, P & Hansbro, P 1970, 'Association between dietary fibre, microbial metabolites and airway obstruction in COPD patients and murine models', 05.01 - Airway pharmacology and treatment, ERS International Congress 2022 abstracts, European Respiratory Society, pp. 3289-3289.
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Carroll, O, Brown, A, Mayall, J, Zounemat-Kermani, N, Gomez, H, Kim, R, Donovan, C, Williams, E, Berthon, B, Pinkerton, J, Wynne, K, Scott, H, Guo, Y, Hansbro, P, Foster, P, Dahlen, S, Adcock, I, Wood, L & Horvat, J 1970, 'Female sex hormones affect asthma severity by altering cellular metabolism in the airways', 05.03 - Allergy and immunology, ERS International Congress 2022 abstracts, European Respiratory Society, pp. 597-597.
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Chen, C, Liu, B, Liao, J, Ding, L, Shan, X & Wang, F 1970, 'Lanthanide ions in nanocrystals for biophotonics application', 2021 International Conference on Optical Instruments and Technology: Optical Systems, Optoelectronic Instruments, Novel Display, and Imaging Technology, 2021 International Conference on Optical Instruments and Technology: Optical Systems, Optoelectronic Instruments, Novel Display and Imaging Technology, SPIE, pp. 102-102.
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Upconversion nanoparticles (UCNPs) is a series of lanthanoid ions doped nanocrystals that are of great interest for biomedical applications, including nanoscale optical sensing and imaging, benefiting from its bright, stable, multicolour emission. Each of the nanoparticles contains thousands of Lanthanide ions, which works as both sensitizers and activators to absorb the near-infrared photons and transfer the energy from sensitizers to activators through nonlinear energy transferring process for an upconverting emission. A few new super-resolution imaging methods have been developed recently based on UCNPs’ unique nonlinear energy transferring process. Most recently, upon these advances, we have found that the thousands of Lanthanide ions provide a strong dielectric resonance effect in a single UCNP. In this work, we will review using the nonlinear response of lanthanoid ions to improve super-resolution nanoscopy. We will also report the ion resonance effect in UCNPs could substantially increase the permittivity and polarizability of nanocrystals, leading to an enhanced optical force on a single 23.3 nm radius UCNP, more than 30 times stronger than the reported value for gold nanoparticles with the same size. The enhanced optical force also provides a way to bypass the optical trapping requirement of “refractive index mismatch”. We further report that the resonance effect could engineer the Rayleigh scattering of UCNPs. These applications suggest a new potential of UCNPs as force probe, scattering probe and fluorescence probe simultaneously for multiplexed imaging.
Chen, H, Galvao, I, Donovan, C, Kim, R, Ortega, D & Hansbro, P 1970, 'Spatial transcriptomics mapped regions in lungs upon cigarette smoking', RESPIROLOGY, WILEY, pp. 121-121.
Chen, H, Galvao, I, Donovan, C, Kim, R, Ortega, D, Idrees, S, Schulte-Schrepping, J, Schaar, A, Faiz, A, Schultze, J & Hansbro, P 1970, 'Spatial transcriptomics (ST) of cigarette smoke (CS)-induced experimental COPD', 03.01 - Molecular pathology and functional genomics, ERS International Congress 2022 abstracts, European Respiratory Society, pp. 3336-3336.
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Cheng, Z, Bartel, S, Nijnatten, JLV, Bults, R, Brandsma, C, Timens, W, Faiz, A, Gosens, R, Berge, MVD & Hylkema, MN 1970, 'Transcriptome analysis indicates more AT2-to-AT1 transition in COPD', 03.03 - Mechanisms of lung injury and repair, ERS International Congress 2022 abstracts, European Respiratory Society, pp. 2503-2503.
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Daly, K, Hsu, A, Nichol, K, Horvat, J, Mayall, J, Hansbro, P & Wark, P 1970, 'Histone deacetylase-6 (HDAC6) promotes protective responses during murine influenza A virus (IAV) infection', 10.01 - Respiratory infections and bronchiectasis, ERS International Congress 2022 abstracts, European Respiratory Society, pp. 1243-1243.
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Daly, K, Hsu, A, Nichol, K, Mayall, J, Horvat, J, Hansbro, P & Wark, P 1970, 'Histone deacetylase-6 promotes protective antiviral responses during influenza an infection', RESPIROLOGY, WILEY, pp. 65-65.
Duong, NMH, Saerens, G, Timpu, F, Buscaglia, MT, Buscaglia, V, Morandi, A, Muller, JS, Maeder, A, Kaufmann, F, Solntsev, AS & Grange, R 1970, 'Spontaneous parametric down-conversion in bottom-up grown lithium niobate microcubes', Conference on Lasers and Electro-Optics, CLEO: QELS_Fundamental Science, Optica Publishing Group, pp. FM2B.7-FM2B.7.
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Etminaniesfahani, A, Gu, H & Salehipour, A 1970, 'An Efficient Relax-and-Solve Algorithm for the Resource-Constrained Project Scheduling Problem', Proceedings of the 11th International Conference on Operations Research and Enterprise Systems, 11th International Conference on Operations Research and Enterprise Systems, SCITEPRESS - Science and Technology Publications, pp. 271-277.
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Favaloro, J, Bryant, C, Abadir, E, Yang, S, Gardiner, S, Nassif, N, Sedger, L, Joshua, D & Ho, PJ 1970, 'Single-cell analysis reveals disease induced perturbations of CD8+T-cell subsets in the bone marrow and peripheral blood of newly diagnosed multiple myeloma patients', CLINICAL LYMPHOMA MYELOMA & LEUKEMIA, CIG MEDIA GROUP, LP, pp. S14-S14.
Fernando, BSM, Luu, LDW, Gore, M, Kaakoush, N & Rodriguez, NC 1970, 'Caspase recruitment domain-containing protein 8 suppresses inflammation, leading to improved survival of Helicobacter pylori in THP-1 cells', JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, WILEY, pp. 34-35.
Geiien, A, Popp, A, Das, D, Junaid, S, Poulton, CG, Chemnitz, M, Marquardt, C, Schmidt, MA & Stiller, B 1970, 'Thermodynamic Control of Nanoliter Volumes of CS2 via Stimulated Brillouin Scattering', Frontiers in Optics + Laser Science 2022 (FIO, LS), Frontiers in Optics, Optica Publishing Group, pp. JTu4A.59-JTu4A.59.
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he, P, Papanicolaou, M, Rutting, S, Reddy, D, Ammit, A, Xenaki, D, Van Reyk, D, Oliver, B & Reddy, K 1970, 'Oxidative stress is a key driving mechanism in the pathogenesis of inflammatory lung diseases', 03.03 - Mechanisms of lung injury and repair, ERS International Congress 2022 abstracts, European Respiratory Society, pp. 3359-3359.
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Hossain, MJ, Kendig, MD, Morris, MJ & Arnold, R 1970, 'IDF21-0176 Spatial memory impairment in type 2 diabetic rats is associated with adiposity and altered glucose metabolism', Diabetes Research and Clinical Practice, Elsevier BV, pp. 109719-109719.
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Irga, P, Torpy, F, Fleck, R, Duani, G, Matheson, S, Douglas, A & Lyu, L 1970, 'The Benefits of Plants at Work', Workplace Wellness Festival, Workplace Wellness Festival, International Conference Centre, Sydney Australia.
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The human environment is the indoor environment.86% of your time every day is spent indoors. As we spend more time indoors, we have an extended exposure time to the pollutants encountered in indoor environments. As far as workplace environments are concerned, more and more people are staying back doing overtime (paid or not), which puts the onus on the employer to provide an indoor environment that does not pose an ongoing risk for the occupants.In Australia, ambient air pollution standards are set by The National Environment Protection (Ambient Air quality) Measure (Air-NEPM). The standards used are similar to those from most western countries. The Air-NEPM standards cover most of the common air pollutants, including particulates less than 10 mm in size (PM10), particulates less than 2.5 mm (PM2.5), SO2, NO2, and CO. Australian threshold limits for indoor workspace CO2 and volatile organic compounds (VOC) are set by Work Safe Australia.Regarding the procedure of air purification by potted plants, many researchers and decades of work have confirmed that the plants remove CO2 through photosynthesis, degrade VOCs through the metabolic action of rhizospheric microbes, and can sequester particulate matter through a range of physical mechanisms.Apart from the occasional report documenting trivial VOC removal capacity by plant tissues , or bacteria on the leaf surface or phyllosphere, the quantitative bioremediation of VOCs is now generally accepted to primarily occur through microbial activity, where the VOCs are used directly as carbon sources by microorganisms. Most research suggests that all potted plant / substrate combinations can remove VOCs at similar rates, with slightly reduced rates for plants grown in hydroculture, probably due to the lower microbial density in the substrate. Two recent experiments have challenged this observation, finding significant variation between plant species, although in common with earlier research, found no patte...
Kapellos, T, Bassler, K, Fujii, W, Pecht, T, Bonaguro, L, Galvao, I, Saglam, A, Dudkin, E, Frishberg, A, De Domenico, E, Horne, A, Donovan, C, Kim, RY, Gallego-Ortega, D, Becker, M, Händler, K, Ulas, T, Hasenauer, J, Pizarro, C, Hansbro, PM, Skowasch, D & Schultze, JL 1970, 'Inflammatory blood neutrophils in COPD stem from activated bone marrow progenitors', Airway cell biology and immunopathology, ERS Lung Science Conference 2022 abstracts, European Respiratory Society, pp. 210-210.
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Kapellos, T, Bassler, K, Fujii, W, Pecht, T, Bonaguro, L, Galvao, I, Saglam, A, Dudkin, E, Frishberg, A, De Domenico, E, Horne, A, Donovan, C, Kim, RY, Gallego-Ortega, D, Becker, M, Händler, K, Ulas, T, Hasenauer, J, Pizarro, C, Hansbro, PM, Skowasch, D & Schultze, JL 1970, 'Inflammatory blood neutrophils in COPD stem from activated bone marrow progenitors', 03.02 - Airway cell biology and immunopathology, ERS International Congress 2022 abstracts, European Respiratory Society, pp. LSC-0210.
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Karp, T, Faiz, A, Kerstjens, HAM, Boudewijn, IM, Kraft, M, Vonk, JM, Nawijn, MC, Heijink, IH, Fabbri, LM, Rabe, KF, Nicolini, G, Papi, A, Brightling, C, Singh, D, Van Der Molen, T, Siddiqui, S, Christenson, S, Guryev, V & Van Den Berge, M 1970, 'Nasal airway epithelium differentiates between asthma and healthy subjects and identifies clinically relevant asthma endotypes', 03.01 - Molecular pathology and functional genomics, ERS International Congress 2022 abstracts, European Respiratory Society, pp. 687-687.
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Kim, RY, Rendle, KA, Mitra, N, Saia, CA, Neslund-Dudas, C, Greenlee, RT, Burnett-Hartman, AN, Honda, SA, Simoff, MJ, Schapira, MM, Meza, R, Ritzwoller, DP & Vachani, A 1970, 'Association of Socioeconomic Status with Adherence to Annual Lung Cancer Screening', AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, International Conference of the American-Thoracic-Society, AMER THORACIC SOC, CA, San Francisco.
Kononov, A, Memar, J & Zinder, Y 1970, 'Algorithms for Flow Shop with Job-Dependent Buffer Requirements'.
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Lim, JH, Wang, JQ, Webb, F, Saxena, K, Enosi Tuipulotu, D, Pandey, A, Man, SM & Talaulikar, D 1970, 'Plasma cells arise from differentiation of clonal lymphocytes and secrete IgM in Waldenström macroglobulinemia', iScience.
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Waldenström macroglobulinemia (WM) is characterized by bone marrow infiltration with malignant lymphoplasmacytic cells (LPCs), a smaller population of plasma cells (PCs), and hypersecretion of IgM monoclonal protein. Here, we show that CD45low, CD38+, and CD138+ PCs and CD45high, CD38−, CD138-, CD19+, and CD20+ LPCs carry a heterozygous L265P mutation in the Toll-like receptor signaling adaptor MYD88. Both PCs and LPCs express the same auto-reactive IgHV sequences, suggesting a similar clonal origin and role for auto-antigens in WM cell survival. PCs are primarily responsible for IgM production even without substantial cell proliferation. When cultured in isolation, LPCs give rise to more differentiated PCs and secrete less IgM. Our analyses suggest that malignant PCs arise from the clonal LPC population, and are primarily responsible for IgM secretion in WM. Targeting malignant PCs may have therapeutic benefits in the treatment of WM and improve the duration of response and potentially, survival.
Luu, LD, Singh, H, Castano-Rodriguez, N, Leach, ST, Stephen, R, Tedla, N, Krishnan, U & Kaakoush, NO 1970, 'ENRICHMENT OF PREVOTELLA IS A CONSISTENT SIGNATURE IN THE METAPLASTIC ESOPHAGUS IN CHILDREN AND ADULTS', GASTROENTEROLOGY, W B SAUNDERS CO-ELSEVIER INC, pp. S833-S833.
Martin, L, Thomas, P, De Silva, P & Sirivivatnanon, V 1970, 'Susceptibility of Heat-Cured Concrete to Deleterious DEF; the Role of Alkali, Sulfate, and Temperature', 76th RILEM Annual Week 2022 and International Conference on Regeneration and Conservation of Structures, Kyoto, Japan.
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Durability of concrete materials is important for their global use in infrastructure. One potential cause of durability loss is delayed ettringite formation (DEF), a form of internal sulfate attack. DEF can lead to deleterious expansion, microcracking, and strength loss in affected elements and is of most concern in precast concrete, with major factors including pore solution alkalinity, elevated curing temperatures, and sulfate and aluminate binder contents. The role of chemical factors and heat in deleterious DEF has been investigated in this study with concrete prisms and hydrated cement paste samples via linear expansion and phase development. Results show that a combination of sustained heat and elevated alkali and sulfate contents are necessary for deleterious DEF to occur.
Martin, L, Thomas, P, De Silva, P & Sirivivatnanon, V 1970, 'The combined role of alkali silica reaction and delayed ettringite formation in durability loss of concrete structures.', Proceedings of the 16th International Conference on Alkali-Aggregate Reaction in Concrete, International Conference on Alkali-Aggregate Reaction in Concrete, LABORATÓRIO NACIONAL DE ENGENHARIA CIVIL, I. P., Lisbon, Portugal, pp. 469-479.
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Durability of concrete as a structural material is key in its worldwide use for buildings and infrastructure,with the lifetime service of concrete greatly impacting its economic, environmental, and social costs.Causes of durability loss in some concrete structures can be attributed to the alkali-silica reaction (ASR)and delayed ettringite formation (DEF). Both are chemical reactions with the potential of deleteriouscracking, expansion, and strength loss in affected elements. Significant overlap exists in the factorscontributing to ASR and DEF in concrete structures, with widely reported evidence of deleterious DEFfrequently occurring in conjunction with mild or moderate ASR. For precast concrete, binder andtemperature limits based on mortar experiments are used during curing to minimise DEF risk. The roleof other constituents in concrete specimens, notably the aggregate, have been overlooked. This paperinvestigates the role of ASR in the susceptibility of concrete to DEF. Concrete specimens weremanufactured under conditions that promoted deleterious ASR and DEF, in including aggregatereactivity, binder composition, and curing temperature. Linear expansion and compressive strengthwere measured over 1-year. Only concrete systems subject to heat-curing and elevated alkali andsulfate contents showed deleterious effects.
Mayall, J, Pillar, A, Daly, K, Brown, A, Essilfie, A, Gomez, H, Kim, R, Nichol, K, Donovan, C, Anderson, G, Frazer, D, Milward, E, Hansbro, P, Reid, D, Hsu, A, Wark, P & Horvat, J 1970, 'Crucial role of iron metabolism in determining outcomes of influenza A virus infection and disease', 10.01 - Respiratory infections and bronchiectasis, ERS International Congress 2022 abstracts, European Respiratory Society, pp. 877-877.
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Mayall, J, Pillar, A, Daly, K, Brown, A, Essilfie, A, Gomez, H, Kim, R, Nichol, K, Donovan, C, Anderson, G, Frazer, D, Milward, E, Hansbro, P, Reid, D, Hsu, A, Wark, P & Horvat, J 1970, 'Iron metabolism affects influenza an infection and associated disease', RESPIROLOGY, WILEY, pp. 211-211.
Mohanty, M 1970, 'Source Attribution of Modern Multi-camera Smartphones', Proceedings of the 2nd International Conference on Image Processing and Vision Engineering, 2nd International Conference on Image Processing and Vision Engineering, SCITEPRESS - Science and Technology Publications.
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Nunez Lendo, CI, Camp, E, Edmondson, J, Kuzhiumparambil, U, Gonzalez de Vega, R, David, H & David, S 1970, 'Beyond growth and survival measurements: integrating multiple traits to inform ecosystem service value of corals propagated for restoration on the Great Barrier Reef', Australian Marine Sciences Association, Cairns.
Pillar, A, Brown, A, Mayall, J, Weaver, J, Essilfie, A, Hoefel, G, Ali, M, Kim, R, Donovan, C, Gomez, H, Vanka, K, Tay, H, Kermani, N, Guo, Y, Mumby, S, Adcock, I, Anderson, G, Fraser, D, Johnstone, D, Milward, E, Hansbro, P, Wark, P, Reid, D, Foster, P & Horvat, J 1970, 'Relationship between interleukin-13 and transferrin receptor-1 responses in asthma pathogenesis', RESPIROLOGY, WILEY, pp. 105-105.
Pillar, A, Brown, A, Mayall, J, Weaver, J, Essilfie, A, Hoefel, G, Ali, MK, Kim, R, Donovan, C, Gomez, H, Vanka, KS, Tay, H, Kermani, N, Guo, Y, Mumby, S, Adcock, I, Anderson, G, Frazer, D, Johnstone, D, Milward, E, Hansbro, P, Wark, P, Reid, D, Foster, P & Horvat, J 1970, 'Relationship between interleukin-13 and transferrin receptor-1 responses in the pathogenesis of asthma', 05.03 - Allergy and immunology, ERS International Congress 2022 abstracts, European Respiratory Society, pp. 4211-4211.
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Pinkerton, J, Kim, R, Brown, A, Rae, B, Donovan, C, Mayall, J, Ali, MK, Scott, H, Berthon, B, Baines, K, Starkey, M, Kermani, N, Guo, Y, Robertson, A, O'Neill, L, Adcock, I, Cooper, M, Gibson, P, Wood, L, Hansbro, P & Horvat, J 1970, 'Interaction between type 2 cytokine and inflammasome responses in the pathogenesis of obesity-associated asthma', 03.02 - Airway cell biology and immunopathology, ERS International Congress 2022 abstracts, European Respiratory Society, pp. 871-871.
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Rathnayake, S, Ditz, B, Van Nijnatten, J, Brandsma, C, Timens, W, Hiemstra, P, Ten Hacken, N, Oliver, B, Kerstjens, H, Van Den Berge, M & Faiz, A 1970, 'Influence of smoking on bronchial epithelial cell composition by cellular deconvolution and IHC', 03.01 - Molecular pathology and functional genomics, ERS International Congress 2022 abstracts, European Respiratory Society, pp. 666-666.
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Reddy, K, Rathnayake, S, Xenaki, D, Faiz, A & Oliver, B 1970, 'The Y-chromosome regulates hallmark features of asthma and COPD', 03.01 - Molecular pathology and functional genomics, ERS International Congress 2022 abstracts, European Respiratory Society, pp. 673-673.
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Rehman, SF, Budden, KF, Quaranta, A, Fuchs, D, Shukla, SD, Brown, A, Alemao, C, Balachandra, L, Gomez, H, Kumar, V, Idrees, S, Horvat, J, Wood, LG, Wheelock, C & Hansbro, PM 1970, 'Soluble epoxide hydrolase inhibition alleviates inflammation in cigarette smoke-induced experimental COPD irrespective of dietary fat content', 05.03 - Allergy and immunology, ERS International Congress 2022 abstracts, European Respiratory Society, pp. 3378-3378.
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Rendle, K, Saia, CA, Vachani, A, Burnett-Hartman, AN, Doria-Rose, V, Neslund-Dudas, C, Oshiro, C, Kim, RY, Lafata, J, Honda, SA, Wainwright, J, Mitra, N & Greenlee, RT 1970, 'Incremental Rates of Imaging and Diagnostic Procedures Attributed to Lung Cancer Screening in Community Practice', AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, International Conference of the American-Thoracic-Society, AMER THORACIC SOC, CA, San Francisco.
Reyhanian, P, Lobo, C, Poulton, C & Agrawal, A 1970, 'A Numerical Study on the impact of Purcell Effect and Spontaneous Emission Factor in Lower-Dimension Semiconductor Nanolasers', Indian Institute of Technology Roorkee.
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This paper presents a numerical approach to estimating the spontaneous emission coupling efficiency in semiconductor lasers with lower-dimension gain mediums. Also, the impact of the Purcell effect F and spontaneous emission factor β on the threshold and the height of the kink in the L-L curves is studied. Our theoretical calculations provide more insights into the laser behavior and help to optimize the laser cavity to achieve a lower threshold and higher coupling efficiency before fabrication.
Reyhanian, P, Lobo, C, Poulton, CG & Agrawal, A 1970, 'A Numerical Study on the impact of Purcell Effect and Spontaneous Emission Factor in Lower-Dimension Semiconductor Nanolaser', XLV Symposium of the Optical Society of India, Conference on Optics, Photonics & Quantum Optics (COPaQ 2022), XLV Symposium of the Optical Society of India, Conference on Optics, Photonics & Quantum Optics (COPaQ 2022), India.
Rose, M, Kim, J, Pierce, J, Copland, D, Nickels, L, Togher, L, Godecke, E, Rai, T, Meinzer, M, Cadilhac, D, Hurley, M, Wilcox, C, Steel, G & Carragher, M 1970, 'Variability in treatment response and self-reported fatigue in participants from the COMPARE randomised controlled trial of intervention for chronic post-stroke aphasia', INTERNATIONAL JOURNAL OF STROKE, SAGE PUBLICATIONS LTD, pp. 32-33.
Rose, ML, Kim, J, Copland, D, Nickels, L, Togher, L, Godecke, E, Rai, T, Meinzer, M, Cadilhac, D, Hurley, M, Wilcox, C, Steel, G, Pierce, JE & Carragher, M 1970, 'Factors associated with treatment response in the COMPARE randomized controlled trial of intervention for chronic poststroke aphasia', INTERNATIONAL JOURNAL OF STROKE, SAGE PUBLICATIONS LTD, pp. 4-4.
Shi, Y, Zounemat Kermani, N, Faiz, A, Chung, KF, Hansbro, PM, Yao, X, Van Den Berge, M, Nawijn, M & Adcock, IM 1970, 'Altered airway epithelial cell landscape in U-BIOPRED severe asthma', 03.01 - Molecular pathology and functional genomics, ERS International Congress 2022 abstracts, European Respiratory Society, pp. 3797-3797.
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Stern, HL, Jarman, J, Gu, Q, Eizagirre Barker, S, Mendelson, N, Chugh, D, Schott, S, Tan, HH, Sirringhaus, H, Aharonovich, I & Atature, M 1970, 'Optically-addressable spins in hexagonal boron nitride at room temperature', 2D Photonic Materials and Devices V, 2D Photonic Materials and Devices V, SPIE, pp. 1-1.
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Tonkaev, P, Fan, Y, Wang, Y, Han, J, Zalogina, A, Tripathi, A, Lee, HC, Park, HG, Makarov, S, Kruk, S, Song, Q, Xiao, S & Kivshar, Y 1970, 'Enhanced multiphoton photoluminescence in metaphotonics', Optics InfoBase Conference Papers.
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We study multiphoton photoluminescence from several types of nonlinear resonant metaphotonic structures. We develop a general theoretical approach to describe such nonlinear effects and confirm our predictions in experiments with perovskite metasurfaces and AlGaAs nanoantennas.
Tonkaev, P, Fan, Y, Wang, Y, Han, J, Zalogina, A, Tripathi, A, Lee, HC, Park, HG, Makarov, S, Kruk, S, Song, Q, Xiao, S & Kivshar, Y 1970, 'Enhancement of multiphoton photoluminescence with resonant metastructures', International Conference on Metamaterials, Photonic Crystals and Plasmonics, pp. 1108-1109.
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Multiphoton photoluminescence is a fundamentally important nonlinear process applied in microfabrication, data storage, and biological imaging. In general, nonlinear processes are much weaker compared with linear ones. We have studied multiphoton photoluminescence in perovskite metasurface and single AlGaAs nanoresonator and achieved significant enhancement in the vicinity of the Mie resonances.
Torpy, F, Irga, P, Fleck, R, Matheson, S & Douglas, A 1970, 'Indoor plants, our environment and happiness', Happiness & Its Causes, Happiness & Its Causes, Pyrmont Theatre, ICC Sydney.
Torpy, F, Irga, P, Fleck, R, Matheson, S, Smith, H, Duani, G, Surawski, N, Douglas, A & Lyu, L 1970, 'Phytoremediation of air pollution', 26th International Clean Air and Environment Conference, 26th International Clean Air and Environment Conference, Adelaide, SA.
Travis, G, Simpson, A & Nassif, N 1970, 'Quantitating PTEN and PTENp1 pseudogene expression: Potential for future cancer therapy', 34th Annual Lorne Cancer Conference, 34th Annual Lorne Cancer Conference, Lorne Victoria.
Van Eeckhoutte, HP, Donovan, C, Kim, R, Khan, H, Jayaraman, R, Dondelinger, Y, Delanghe, T, Beal, A, Geddes, B, Bertin, J, Vanden Berghe, T, Vandenabeele, P, Vanaudenaerde, B, Deforce, D, Skevin, S, Van Nieuwerburgh, F, Verhamme, F, Joos, G, Brusselle, G, Bertrand, M, Hansbro, P & Bracke, K 1970, 'Inhibiting RIPK1 kinase activity is protective in experimental models of COPD', Airway cell biology and immunopathology, ERS Lung Science Conference 2022 abstracts, European Respiratory Society, pp. 19-19.
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van Nijnatten, J, Faiz, A, Timens, W, Guryev, V, Slebos, D, Klooster, K, Hartman, J, Kole, T, Choy, DF, Grimbaldeston, M, Rosenberger, CM, Heijink, I, Pouwels, SD, Kerstjens, H, Brandsma, C & Van Den Berge, M 1970, 'Unique differentially expressed genes in bronchial brushes in severe COPD', 03.01 - Molecular pathology and functional genomics, ERS International Congress 2022 abstracts, European Respiratory Society, pp. 3362-3362.
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Vettori, L, Joukhdar, H, Anh, HT, Sarmast, HMS, Filipe, E, Cox, T, Kabakova, I, Rnjak-Kovacina, J & Gentile, C 1970, 'Silk fibroin as a bioink for cardiovascular applications', TISSUE ENGINEERING PART A, Tissue-Engineering-and-Regenerative-Medicine-International-Society-Asia-Pacific-Chapter Conference (TERMIS-AP), MARY ANN LIEBERT, INC, SOUTH KOREA, Jeju, pp. 264-264.
Wang, Y, Thaler, M, Salgado-Benvindo, C, Ly, N, Leijs, AA, Ninaber, DK, Van Hemert, MJ, Hiemstra, PS, Van Der Does, AM & Faiz, A 1970, 'RNA sequencing unravels unique host transcriptional responses to infection with SARS-CoV-2 in well differentiated primary human bronchial epithelial cells compared to other coronaviruses', 03.02 - Airway cell biology and immunopathology, ERS International Congress 2022 abstracts, European Respiratory Society, pp. 897-897.
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Weiner, M, Kim, KW, Hu, TC, Solntsev, A & Blanco-Redondo, A 1970, 'Photon-Pair Generation in Defect-Free Surface Modes', 2022 Conference on Lasers and Electro-Optics, CLEO 2022 - Proceedings.
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We experimentally demonstrate simultaneous generation and propagation of photon pairs in defect-free surface modes in an array of coupled sinusoidal waveguides. The measured biphoton correlations remain robust to tuning the curvature.
Weiner, M, Kim, KW, Hu, TC, Solntsev, A & Blanco-Redondo, A 1970, 'Photon-Pair Generation in Defect-Free Surface Modes', Optics InfoBase Conference Papers.
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We experimentally demonstrate simultaneous generation and propagation of photon pairs in defect-free surface modes in an array of coupled sinusoidal waveguides. The measured biphoton correlations remain robust to tuning the curvature.
Yamamura, K, Zhu, L, Irvine, C, Singh, M, Bansal, V, Scott, J, Phillips, MR, Ton-That, C & Jallandhra, A 1970, 'Luminescence signatures of nitrogen in β-Ga2O3 nanowires', Oxide-based Materials and Devices XIII, Oxide-based Materials and Devices XIII, SPIE, pp. 59-59.
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Yaqub, W, Mohanty, M & Suleiman, B 1970, 'Privacy-Preserving Online Proctoring using Image-Hashing Anomaly Detection', 2022 International Wireless Communications and Mobile Computing (IWCMC), 2022 International Wireless Communications and Mobile Computing (IWCMC), IEEE, pp. 1113-1118.
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Zalogina, A, Carletti, L, Tripathi, A, Lee, HC, Shadrivov, I, Park, HG, Kivshar, Y & Kruk, S 1970, 'High-Harmonic Generation from Subwavelength Resonators', Optics InfoBase Conference Papers.
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We generate up to the 7th optical harmonic from a single AlGaAs resonator. The resonator hosts engineered modes associated with bound states in the continuum. We investigate both direct and cascade mechanisms of high harmonic generation.
Zalogina, A, Tonkaev, P, Tripathi, A, Lee, HC, Carletti, L, Park, HG, Kruk, S & Kivshar, Y 1970, 'Observation of Giant Five-Photon Upconversion Luminescence in Subwavelength AlGaAs Resonators', Optics InfoBase Conference Papers.
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We design and fabricate individual subwavelength AlGaAs nanoantennas supporting Mie resonances in the mid-infrared spectral range. Near the resonant modes, we observe five-photon upconversion photoluminescence in the visible spectral range.
Zhang, G, Bao, G & Huang, Z 1970, '1,3-Diaminopropane Bisborane as a Hydrogen Storage Media', Clearwater Clean Energy Conference 2022, 46th International Technical Conference on Clean Energy, Coal Technologies Associates, pp. 139-139.
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Reports
Ajani, P, Dove, M, Farrell, H, O'Connor, W, Tesoriero, M, Verma, A, Hughes, B & Murray, S University of Sydney Australia 2022, Transforming Australian Shellfish Production: Lower Honeymoon Bay Harvest Area, Wagonga Inlet. Report on Stage 1, December 2017-March 2021., Sydney, Australia.
Ajani, P, Dove, M, Farrell, H, O'Connor, W, Tesoriero, M, Verma, A, Zammit, A, Hughes, B & Murray, S University of Technology Sydney 2022, Transforming Australian Shellfish Production. Pambula Lake Harvest Area, Pambula River. Report on Satge 1, Sept 2016-March 2021., Sydney Australia.
Ajani, P, Dove, M, Farrell, H, O'Connor, W, Tesoriero, M, Verma, A, Zammit, A, Hughes, B & Murray, S University of Technology Sydney 2022, Transforming Australian Shellfish Production: Goodnight Island Harvest Area, Shoalhaven and Crookhaven Rivers. Report on Stage 1, December 2017-March 2021, Sydney Australia.
Ajani, P, Dove, M, Farrell, H, O'Connor, W, Tesoriero, M, Verma, A, Zammit, A, Hughes, B & Murray, S University of Sydney Techology 2022, Transforming Australian Shellfish Production: Pelican Point Harvest Area - Manning River. Report on Stage 1, December 2017-March 2021., Sydney Australia.
Ajani, P, Dove, M, Farrell, H, O'Connor, W, Tesoriero, M, Verma, A, Zammit, A, Hughes, B & Murray, SA University of Technology Sydney 2022, Transforming Australian Shellfish Production: Long Island Harvest Area, Wallis Lake. Report on Stage 1, December 2017-March 2021., Sydney Australia.
Berry, F, Retamal, M, Kuzhiumparambil, U & Ralph, P University of Technology Sydney 2022, Market and sustainability potential for algal bioplastics in Australia, Sydney NSW.
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This paper has been developed by the Institute for Sustainable Futures and the Climate Change Cluster (C3) at the University of Technology Sydney. UTS's Climate Change Cluster (C3) are developing flexible bioplastics from algae which have a range of potential applications, in particular to replace petroleum-based plastics and potentially offer a more sustainable alternative. This report aims to provide: • a brief primer on the potential market for algal bioplastics • identification of key hotspots for sustainability considerations in product design • a discussion of the current policy context and how this will influence bioplastic development, and • recommendations for product developers. This paper has been written for investors, government, researchers and the general public, to provide information on the sustainability opportunities and constraints of algal bioplastics in a circular economy.
Trestrail, C, Tondl, E, Fischer, A, Potts, J, Scanes, P, Seymour, J & Doblin, M University of Technology Sydney 2022, Research needs for the assessment and monitoring of nutrients, chemicals & antimicrobials in the marine environment: scoping study., no. Report 1.16, Sydney.
Other
Alabd, R, Bishop, AN, Safavi-Naeini, M, Chacon, A & Franklin, DR 2022, 'A treatment planning system for manifold multi-ion particle therapy', Research Square Platform LLC.
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Aliee, H, Massip, F, Qi, C, Stella de Biase, M, van Nijnatten, J, Kersten, ETG, Kermani, NZ, Khuder, B, Vonk, JM, Vermeulen, RCH, Neighbors, M, Tew, GW, Grimbaldeston, MA, ten Hacken, NHT, Hu, S, Guo, Y, Zhang, X, Sun, K, Hiemstra, PS, Ponder, BA, Mäkelä, MJ, Malmström, K, Rintoul, RC, Reyfman, PA, Theis, FJ, Brandsma, C, Adcock, IM, Timens, W, Xu, C, van den Berge, M, Schwarz, RF, Koppelman, GH, Nawijn, MC & Faiz, A 2022, 'Determinants of expression of SARS‐CoV‐2 entry‐related genes in upper and lower airways', Wiley, pp. 690-694.
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Ashhurst, A, Johansen, M, Maxwell, J, Ashley, C, Aggarwal, A, Siddiquee, R, Miemczyk, S, Nguyen, D, Mackay, J, Counoupas, C, Byrne, S, Turville, S, Steain, M, Triccas, J, Hansbro, P, Payne, R & Britton, W 2022, 'Mucosal TLR2-activating protein-based vaccination induces potent pulmonary immunity and protection against SARS-CoV-2 in mice', Research Square Platform LLC.
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Assadi, MHN, Fronzi, M & Hanaor, DAH 2022, 'Unusual ferrimagnetic ground state in rhenium ferrite'.
Brown, A, Donovan, C, Thorburn, A, Ng, K, Kim, R, Balachandran, L, Horvat, J & Hansbro, P 2022, 'Bacterial components suppress experimental acute lung injury through regulatory T-cells', WILEY, pp. 73-73.
Butterworth, NJ, Wallman, JF, Johnston, NP, Dawson, BM & McGaughran, A 2022, 'The blowflyChrysomya latifronsinhabits fragmented rainforests, but lacks genetic diversity and population structure', Cold Spring Harbor Laboratory.
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Camara, M, Dubern, J, Romero, M, Mai-Prochnow, A, Messina, M, Trampari, E, Gijzel, HN-V, Chan, K-G, Carabelli, A, Barraud, N, Lazenby, J, Chen, Y, Robertson, S, Malone, J, Williams, P & Heeb, S 2022, 'ToxR is a c-di-GMP binding protein that modulates surface-associated behaviour in Pseudomonas aeruginosa', Research Square Platform LLC.
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Carroll, O, Brown, A, Mayall, J, Gomez, H, Kim, R, Donovan, C, Williams, E, Berthon, B, Pinkerton, J, Hansbro, P, Foster, P, Wynne, K, Scott, H, Wood, L & Horvat, J 2022, 'A relationship between female sex hormones, cellular metabolism and asthma', WILEY, pp. 21-21.
Charon, J, Kahlke, T, Larsson, ME, Abbriano, R, Commault, A, Burke, J, Ralph, P & Holmes, EC 2022, 'Diverse RNA viruses associated with diatom, eustigmatophyte, dinoflagellate and rhodophyte microalgae cultures', Cold Spring Harbor Laboratory.
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Chavoshi Borujeni, S, Nouri, H, Nagler, P, Abassi, N, Pradhan, B & Huete, A 2022, 'The impact of drought on urban green space'.
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Chen, C & Jin, D 2022, 'Giant nonlinearity in upconversion nanoparticles', Springer Science and Business Media LLC, pp. 553-554.
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Chen, C, Ding, L, Liu, B, Du, Z, Liu, Y, Di, X, Shan, X, Lin, C, Zhang, M, Xu, X, Zhong, X, Wang, J, Chang, L, Halkon, BJ, Chen, X, Cheng, F & Wang, F 2022, 'Exploiting dynamic nonlinearity in upconversion nanoparticles for super-resolution imaging'.
Chen, H, Aneman, I, Nikolic, V, Orlic, NK, Mikovic, Z, Stefanovic, M, Cakic, Z, Jovanovic, H, Town, S, Padula, M & McClements, L 2022, 'Maternal plasma proteome profiling of biomarkers and pathogenic mechanisms of early-onset and late-onset preeclampsia', Research Square Platform LLC.
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Chen, L, Hoefel, GA, Pathinayake, PS, Reid, A, Kelly, C, HuiYing, T, Kim, RY, Hansbro, PM, Brody, SL, Foster, PS, Horvat, JC, Riveros, C, Wark, PAB & Kaiko, GE 2022, 'Single cell RNA-seq identifies inflammation-induced loss of CFTR-expressing airway ionocytes in non-eosinophilic asthma', Cold Spring Harbor Laboratory.
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Chen, Y, White, S, Ekimov, EA, Bradac, C, Toth, M, Aharonovich, I & Tran, TT 2022, 'Ultralow-power cryogenic thermometry based on optical-transition broadening of a two-level system in diamond'.
Chhor, M, Tulpar, E, Nguyen, T, Cranfield, C, Gorrie, CA, Chan, YL, Chen, H, Oliver, BG, McClements, L & McGrath, KC 2022, 'E-cigarette Aerosol Condensate leads to Impaired Coronary Endothelial Cell Health and Restricted Angiogenesis', Research Square Platform LLC.
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Cranfield, CG 2022, 'Preface', p. v.
Cui, G, Konciute, MK, Ling, L, Esau, L, Raina, J-B, Han, B, Salazar, OR, Presnell, JS, Rädecker, N, Zhong, H, Menzies, J, Cleves, PA, Liew, YJ, Krediet, CJ, Sawiccy, V, Cziesielski, MJ, Guagliardo, P, Bougoure, J, Pernice, M, Hirt, H, Voolstra, CR, Weis, VM, Pringle, JR & Aranda, M 2022, 'Molecular insights into the Darwin paradox of coral reefs from the sea anemone Aiptasia', Cold Spring Harbor Laboratory.
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Daniels, RK, Mallinson, JB, Heywood, ZE, Bones, PJ, Arnold, MD & Brown, SA 2022, 'Reservoir Computing with 3D Nanowire Networks'.
Dhungana, A, Becchi, S, Leake, J, Morris, G, Avgan, N, Balleine, BW, Vissel, B & Bradfield, LA 2022, 'Goal-directed action is transiently impaired in an hAPP-J20 mouse model of Alzheimer’s disease, and in aging male mice regardless of genotype', Cold Spring Harbor Laboratory.
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Di, X, Su, QP, Wang, D, Liu, Y, Maddahfar, M, Zhou, J & Jin, D 2022, 'Spatiotemporally Mapping Thermodynamics of Lysosomes and Mitochondria using Cascade Organelle-Targeting Upconversion Nanoparticles', Cold Spring Harbor Laboratory.
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Doane, MP, Ostrowski, M, Brown, M, Bramucci, A, Bodrossy, L, van de Kamp, J, Bissett, A, Steinberg, P, Doblin, MA & Seymour, J 2022, 'Defining marine bacterioplankton community assembly rules by contrasting the importance of environmental determinants and biotic interactions', Cold Spring Harbor Laboratory.
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Dougan, KE, Bellantuono, AJ, Kahlke, T, Abbriano, RM, Chen, Y, Shah, S, Granados-Cifuentes, C, van Oppen, MJH, Bhattacharya, D, Suggett, DJ, Rodriguez-Lanetty, M & Chan, CX 2022, 'Whole-genome duplication in an algal symbiont bolsters coral heat tolerance', Cold Spring Harbor Laboratory.
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Dupuy, A, Santamaría, CA, Yeheskel, A, Gräter, F, Hogg, PJ, Passam, FH & Chiu, J 2022, 'Mechano-redox control of Mac-1 de-adhesion from ICAM-1 by protein disulfide isomerase promotes directional movement of neutrophils under flow', Cold Spring Harbor Laboratory.
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Elbourne, M, Fu, S, Cawley, A, Bowen, C & Gupta, A 2022, 'Metabolomic analysis of equine urine to determine route of altrenogest administration', Elsevier BV, pp. S55-S56.
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Fernandez, TT, Johnston, B, Gross, S, Cozic, S, Poulain, M, Mahmodi, H, Kabakova, I, Withford, M & Fuerbach, A 2022, 'Ultrafast laser inscribed waveguides in tailored fluoride glasses: An enabling technology for mid-infrared integrated photonics devices'.
Fiedler, S, Ton-That, C & Phillips, MR 2022, 'Hydrothermally grown defect-free ZnO nanorods with high angular distribution for enhanced excitonic emission', Research Square Platform LLC.
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Fu, S, Shi, W, Luo, T, He, Y, Zhou, L, Yang, J, Yang, Z, Liu, J, Liu, X, Guo, Z, Yang, C, Liu, C, Huang, Z-L, Ries, J, Zhang, M, Xi, P, Jin, D & Li, Y 2022, 'Field dependent deep learning enables high-throughput whole-cell 3D super-resolution imaging', Cold Spring Harbor Laboratory.
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Gantier, M, Ullah, T, Johansen, M, Balka, K, Ambrose, R, Gearing, L, Wenholz, D, Zeng, J, Miemczyk, S, Nguyen, D, Venkatraman, R, Dennis, M, Alharbi, A, Ellyard, J, Wong, W, Kile, B, Vinuesa, C, Kelly, G, Hansbro, P, Laczka, O, De Nardo, D, Hansbro, N & Kumar, N 2022, 'Pharmacological inhibition of TBK1/IKKε blunts COVID-19 immunopathology', Research Square Platform LLC.
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Garces, LP, Kolar, J, Sherris, M & Ungolo, F 2022, 'Affine Mortality Models with Jumps: Parameter Estimation and Forecasting'.
Ghorbanpour, M, Richards, C, Pienaar, D, Sesperez, K, Es.c, HA, Nikolic, V, Orlic, NK, Mikovic, Z, Stefanovic, M, Cakic, Z, Alqudah, A, Cole, L, Gorrie, C, McGrath, K, Kavurma, MM, Warkianib, ME & McClements, L 2022, 'A placenta-on-a-chip model to determine the regulation of FKBPL and galectin-3 in preeclampsia', Research Square Platform LLC.
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Grassi, G, Schwingshackl, C, Gasser, T, Houghton, RA, Sitch, S, Canadell, JG, Cescatti, A, Ciais, P, Federici, S, Friedlingstein, P, Kurz, WA, Sanz Sanchez, MJ, Abad Viñas, R, Alkama, R, Ceccherini, G, Kato, E, Kennedy, D, Knauer, J, Korosuo, A, McGrath, MJ, Nabel, J, Poulter, B, Rossi, S, Walker, AP, Yuan, W, Yue, X & Pongratz, J 2022, 'Mapping land-use fluxes for 2001–2020 from global models to national inventories', Copernicus GmbH.
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Hardy, S, Patrick, R, Liesinger, L, Pöttler, M, Rech, L, Gindlhuber, J, Mabotuwana, N, Ashour, D, Stangl, V, Bigland, M, Murtha, L, Starkey, M, Scherr, D, Hansbro, P, Höfler, G, Ramos, G, Cochain, C, Harvey, R, Birner-Gruenberger, R, Boyle, A & Rainer, P 2022, 'Extracellular Matrix Protein 1 as a Mediator of Inflammation-Induced Fibrosis After Myocardial Infarction', Elsevier BV, pp. S311-S311.
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BackgroundFibrosis is a hallmark of heart disease, particularly following myocardial infarction (MI) and in heart failure. We previously identified a key role for extracellular matrix protein (ECM1) in wound healing post-MI but the cellular origin and mechanism of ECM1 remained elusive. Here, we investigate the spatiotemporal cellular origin of ECM1 in healthy and diseased human and mouse hearts, and ECM1 dependent human cardiac fibroblast (HuCFb) signalling mechanisms.MethodsECM1 specific analysis of existing single-cell/-nuclei RNA sequencing data was conducted. ECM1 expression was assessed in non-failing (NF), ischaemic (ICM) and dilated (DCM) failing human heart tissue via immunoblotting (n=8), immunohistochemistry (ICM; n=8, NF; n=4) and mRNA in-situ hybridisation (n=3). HuCFbs were treated with recombinant ECM1 and assessed via phosphoproteomics (n=6), wound healing assay (n=4), MTT assay (n=8), qPCR (n=6).ResultsECM1 originates from fibroblasts, macrophages/monocytes (MΦ/Mo), and pericytes/vascular cells in uninjured human and mouse hearts. In mouse hearts post-MI, ECM1 originates predominantly from M1MΦ/Mo at day-3, and myofibroblasts and M2MΦ’s at day-7, and expression correlated with cell-cell communication, collagen organisation, inflammation, adhesion, and migration. Fittingly, ECM1 expression was upregulated in human ICM (p=0.048) and DCM (p=0.027), localised interstitially to fibrotic, inflammatory, and peri-vascular areas. In vitro, ECM1 inhibited HuCFb migration (p=0.044) and CCL2 mRNA expression, and stimulated inflammatory (IL-6, IL-1β), fibrotic (TGF-β1, Col1a2), and non-canonical Wnt5a mRNA expression (p<0.05). Phosphoproteomics showed ECM1 stimulates HuCFb Rho protein, cell-cell adhesion, and chemotactic signalling pathways.ConclusionsECM1 may represent a novel mechanism in facilitating inflammation-fibrosis crosstalk post-MI, and a potential therapeutic target.
He, VX & Wand, MP 2022, 'Bayesian Generalized Additive Model Selection Including a Fast Variational Option'.
Hinners, J, Argyle, PA, Walworth, NG, Doblin, MA, Levine, NM & Collins, S 2022, 'Multitrait diversification in marine diatoms in constant and warmed environments', Cold Spring Harbor Laboratory.
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Idrees, S 2022, 'Identification of new target genes in COPD'.
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TSANZ NSW/ACT Branch Meeting
Idrees, S 2022, 'Transcriptomic profile of human bronchial biopsies reveals new target genes in COPD'.
Jinni, Y, Unnikrishnan, K, Sushil, B, Russell, D, Nadia, S & Shanlin, F 2022, 'Investigation of metabolic biomarkers: A metabolomics approach', Elsevier BV, pp. S57-S57.
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Johnson, MS, Burns, BP, Herdean, A, Angeloski, A, Ralph, P, Morris, T, Kindler, G, Wong, HL, Kuzhiumparambil, U, Sedger, L & Larkum, AWD 2022, 'A Cyanobacteria Enriched Layer of Shark Bay Stromatolites Reveals a New <em>Acaryochloris</em> strain Living in near Infrared Light', MDPI AG.
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Keen, B, Cawley, A, Reedy, B, Noble, G & Fu, S 2022, 'A statistical focus on doping using a metabolomics approach', Elsevier BV, pp. S58-S58.
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Kendig, MD & Bradfield, LA 2022, 'Association learning: Dopamine and the formation of backward associations', Elsevier BV, pp. R769-R771.
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The activity of dopamine neurons is critical for the ability to learn and update cue-reward associations. New work in rats shows that dopamine transients are also critical for the formation of backward associations in which the reward precedes the neutral stimulus.
Keoghan, S 2022, 'Don’t want to share? Here’s the smartest way to play tonight’s $160m powerball', Sydney Morning Herald.
Kim, R, Sunkara, K, Bracke, K, Jarnicki, A, Donovan, C, Hsu, A, Ieni, A, Beckett, E, Galvao, I, Wijnant, S, Ricciardolo, F, Di Stefano, A, Haw, T, Liu, G, Ferguson, A, Palendira, U, Wark, P, Conickx, G, Mestdagh, P, Brusselle, G, Caramori, G, Foster, P, Horvat, J & Hansbro, P 2022, 'MicroRNA-21 promotes chronic obstructive pulmonary disease through a SATB1/S100A9/NF-kappa B axis', WILEY, pp. 127-128.
Kole, T, Pouwels, SD, Bults, R, Ketelaar, ME, Guryev, V, Koll, L, Kerstjens, HAM, Van Den Berge, M & Faiz, A 2022, 'Airway Wall Splice-QTL Analysis Reveals Novel Downstream Mechanisms for Well-Known GWAS Asthma-SNPs', American Thoracic Society.
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Krishnan, S, DeMaere, MZ, Beck, D, Ostrowski, M, Seymour, JR & Darling, AE 2022, 'Rhometa: Population recombination rate estimation from metagenomic read datasets', Cold Spring Harbor Laboratory.
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Kruk, D, Yeung, A, Faiz, A, Hacken, NHTT, Timens, W, Kuppevelt, TH, Daamen, W, Hof, D, Harmsen, MC, Rojas, M & Heijink, IH 2022, 'Gene expression profiles in mesenchymal stromal cells from bone marrow, adipose tissue and lung tissue of COPD patients and controls', Research Square Platform LLC.
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Kumar, V, Horvat, J, Wark, P, Whiteman, M & Hansbro, P 2022, 'Hydrogen sulfide attenuates cigarette smoke-induced oxidative stress and inflammation in human primary bronchial epithelial cells and experimental COPD', European Respiratory Society, pp. 3369-3369.
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Kumar, V, Horvat, J, Whiteman, M & Hansbro, P 2022, 'Hydrogen Sulfide Prevents Cigarette Smoke-Induced Development of Hallmark Features of COPD in Mice and Interleukin-8 Production in Human Primary Bronchial Epithelial Cells', American Thoracic Society, pp. A2413-A2413.
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Li, F-J, Starrs, L, Mathur, A, Enosi Tuipulotu, D, Man, SM & Burgio, G 2022, 'GBP1 promotes killing of multidrug-resistantAcinetobacter baumanniiand promotes host protection via interferon signalling and inflammasome activation', Cold Spring Harbor Laboratory.
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Li, M-Y, Qin, Y-Q, Li, J-S, Zhao, P, Tian, Y-G, Li, K-C, Oliver, BG & Liu, X-F 2022, 'Effective-Component Compatibility of Bufei Yishen Formula Ⅲ Ameliorated COPD By Improving Airway Epithelial Cell Senescence Via Promoting Mitophagy By Nrf2/PINK1 Pathway', Research Square Platform LLC.
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Liddell, JR, Hilton, JBW, Kysenius, K, Nikseresht, S, McInnes, LE, Hare, DJ, Paul, B, Trist, BG, Double, KL, Mercer, SW, Ayton, S, Roberts, BR, Beckman, JS, McLean, CA, White, AR, Donnelly, PS, Bush, AI & Crouch, PJ 2022, 'Microglial ferroptotic stress causes non-cell autonomous neuronal death', Cold Spring Harbor Laboratory.
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Llewelyn, J, Strona, G, Dickman, CR, Greenville, AC, Wardle, GM, Lee, MSY, Doherty, S, Shabani, F, Saltré, F & Bradshaw, CJA 2022, 'Predicting predator-prey interactions in terrestrial endotherms using random forest', Cold Spring Harbor Laboratory.
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Luu, LD, Singh, H, Castaño-Rodríguez, N, Leach, ST, Stephen, R, Tedla, N, Krishnan, U & Kaakoush, NO 2022, 'Mo1603: ENRICHMENT OF PREVOTELLA IS A CONSISTENT SIGNATURE IN THE METAPLASTIC ESOPHAGUS IN CHILDREN AND ADULTS', Elsevier BV, pp. S-833.
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Macaulay, M, Darling, AE & Fourment, M 2022, 'Fidelity of Hyperbolic Space for Bayesian Phylogenetic Inference'.
Mi, C, Guan, M, Zhang, X, Yang, L, Wu, S, Yang, Z, Guo, Z, Liao, J, Zhou, J, Jin, D & Yuan, X 2022, 'High Spatial and Temporal Resolution NIR-IIb Gastrointestinal Imaging in Mice'.
Migulina, N, Tjin, G, Faiz, A, Borghuis, T, Metzlar, M, Dijk, EM, Timens, W, Gosens, R, Brandsma, C-AA & Burgess, JK 2022, 'Differential Roles for Lysyl Oxidase (Like) Family Members in Chronic Obstructive Pulmonary Disease; from Gene and Protein Expression to Function', American Thoracic Society, pp. A3635-A3635.
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Moheimani, F, Shahdab, N, Cummings, S, Hansbro, PM & Ward, C 2022, 'Key role of dysregulated airway epithelium in response to respiratory viral infections in asthma', European Respiratory Society (ERS), pp. 00314-2022.
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A differentiated air-liquid interface model shows that the airway epithelium plays a key role in response to respiratory viral infections in people with asthma https://bit.ly/3yDgiX1.
Newing, T, Brewster, JL, Yu, H, Johnston, NP, Fitschen, LJ & Tolun, G 2022, 'Structure of phage λ Redβ177 annealase shows how it anneals DNA strands during single-strand annealing homologous DNA recombination', Cold Spring Harbor Laboratory.
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Nguyen, LT, Larkin, BP, Hou, M, Glastras, SJ, Chen, H, Faiz, A, Chen, J, Wang, R, Pollock, C & Saad, S 2022, 'LOW-DOSE HYDRALAZINE ATTENUATES OBESITY-RELATED CHRONIC KIDNEY DISEASE AND NORMALISES RENAL DNA METHYLATION IN MICE', WILEY, pp. 54-54.
Nielsen, JJV, Matthews, G, Frith, KR, Harrison, HB, Marzonie, Slaughter, KL, Suggett, DJ & Bay, LK 2022, 'Experimental considerations of acute heat stress assays to quantify coral thermal tolerance', Research Square Platform LLC.
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Niu, J-Q, Yu, G, Su, Y, Guo, C, Yi, C, Yu, B, Chen, H, Cui, Y, Wang, X, Wang, Y, Chen, X, Wang, S, Wang, Q, Chen, X, Hu, X, Mei, F, Verkhratsky, A & Xiao, L 2022, 'Pathological oligodendrocyte precursor cells revealed in human schizophrenic brains and trigger schizophrenia-like behaviors and synaptic defects in genetic animal model', Research Square Platform LLC.
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Nonahal, M, Li, C, Tjiptoharsono, F, Ding, L, Stewart, C, Scott, J, Toth, M, Ha, ST, Kianinia, M & Aharonovich, I 2022, 'Coupling Spin Defects in Hexagonal Boron Nitride to Titanium Oxide Ring Resonators'.
Olekhno, NA, Petrov, MI, Iorsh, IV, Sukhorukov, AA & Solntsev, AS 2022, 'Generating N00N-states of surface plasmon-polariton pairs in a nonlinear nanoparticle on metallic substrate', IEEE.
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Patel, VK, Paudel, KR, Shukla, SD, Liu, G, Oliver, BG, Hansbro, PM & Dua, K 2022, 'Toll-like receptors, innate immune system, and lung diseases: a vital trilateral association.', IfADo - Leibniz Research Centre for Working Environment and Human Factors, Dortmund, pp. 519-523.
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Paudel, KR 2022, 'Defining and treating the physiological effects of bushfire smoke'.
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Bushfire Mini Symposium-2022
Paudel, KR 2022, 'Impact of bushfire on respiratory health'.
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HEAL conference – 23-24 Nov 2022, Australia
Paudel, KR, De Rubis, G, Panth, N, Singh, SK, Chellappan, DK, Hansbro, PM & Dua, K 2022, 'Nanomedicine and medicinal plants: Emerging symbiosis in managing lung diseases and associated infections.', IfADo - Leibniz Research Centre for Working Environment and Human Factors, Dortmund, pp. 1299-1303.
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Peterson, E, Söderström, B, Prins, N, Le, GHB, Hartley-Tassell, LE, Evenhuis, C, Birkholm Grønnemose, R, Andersen, TE, Møller-Jensen, J, Iosifidis, G, Duggin, IG, Saunders, B, Harry, EJ & Bottomley, AL 2022, 'The role of bacterial size, shape and surface in macrophage engulfment of uropathogenicE. colicells', Cold Spring Harbor Laboratory.
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Pham, NHT, Joglekar, MV, Wong, WKM, Nassif, NT, Simpson, AM & Hardikar, AA 2022, 'The role of short-chain fatty acids on insulin sensitivity: a systematic review and meta-analysis', Cold Spring Harbor Laboratory.
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Rathnayake, S, Ditz, B, van Nijnatten, J, Hansbro, P, Brandsma, C, Timens, W, Hiemstra, P, ten-Hacken, N, Oliver, B, Kerstjens, H, van den Berge, M & Faiz, A 2022, 'Impact of smoking on bronchial-mucus barrier cellular composition and transcriptome', WILEY, pp. 116-117.
Rouet, R, Henry, JY, Johansen, MD, Sobti, M, Balachandran, H, Langley, DB, Walker, G, Lenthall, H, Jackson, J, Ubiparipovic, S, Mazigi, O, Schofield, P, Burnett, DL, Brown, SHJ, Martinello, M, Hudson, B, Gilroy, N, Post, JJ, Kelleher, A, Jäck, H-M, Goodnow, CC, Turville, SG, Rawlinson, WD, Bull, RA, Stewart, AG, Hansbro, PM & Christ, D 2022, 'Broadly neutralizing SARS-CoV-2 antibodies through epitope-based selection from convalescent patients', Cold Spring Harbor Laboratory.
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Schaeper, OC, Yang, Z, Kianinia, M, Fröch, JE, Komar, A, Mu, Z, Gao, W, Neshev, D & Aharonovich, I 2022, 'Monolithic Silicon Carbide Metalenses'.
Seymour, JR 2022, 'Forecasting ocean microbiome shifts', Springer Science and Business Media LLC, pp. 747-748.
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Shan, X, Ding, L, Wen, S, Chen, C, Wang, D, Zhu, H, Nie, P, Lu, X, Wang, S, Zhong, X, Su, Q, Liu, B, Lu, J, Reece, P, Chang, L, Jin, D & Wang, F 2022, 'Single charge regime electrodynamic force measuring in solution by upconversion photonic force microscope', Research Square Platform LLC.
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Sheikh, Z, Granata, A, Zhang, Y, Mahvizani, HMG, Silva, D, Young, PM, Casettari, L, Ong, HX & Traini, D 2022, 'Development of a 3D printed in vitro integrated oro-pharyngeal air-liquid interface cellular throat model for drug transport', Research Square Platform LLC.
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Shi, H, Zhang, L, Yu, T-K, Zheng, L, Ke, H, Johnson, B, Rath, E, Lee, K, Klebe, S, Kao, S, Qin, KL, Pham, HNT, Vuong, Q & Cheng, YY 2022, 'Leptospermum extract (QV0) suppresses pleural mesothelioma tumour growthin vitroandin vivoby mitochondrial dysfunction associated apoptosis', Cold Spring Harbor Laboratory.
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Shibl, AA, Ochsenkühn, MA, Mohamed, AR, Isaac, A, Coe, LSY, Yun, Y, Skrzypek, G, Raina, J-B, Seymour, JR, Afzal, AJ & Amin, SA 2022, 'Molecular mechanisms of microbiome modulation by the eukaryotic secondary metabolite azelaic acid', Cold Spring Harbor Laboratory.
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Slob, EMA, Faiz, A, van Nijnatten, J, Vijverberg, SJH, Longo, C, Kutlu, M, Chew, FT, Sio, YY, Herrera‐Luis, E, Espuela‐Ortiz, A, Perez‐Garcia, J, Pino‐Yanes, M, Burchard, EG, Potočnik, U, Gorenjak, M, Palmer, C, Maroteau, C, Turner, S, Verhamme, K, Karimi, L, Mukhopadhyay, S, Timens, W, Hiemstra, PS, Pijnenburg, MW, Neighbors, M, Grimbaldeston, MA, Tew, GW, Brandsma, CA, Berce, V, Aliee, H, Theis, F, Sin, DD, Li, X, van den Berge, M, Maitland‐van der Zee, AH & Koppelman, GH 2022, 'Association of bronchial steroid inducible methylation quantitative trait loci with asthma and chronic obstructive pulmonary disease treatment response', Wiley, pp. 1-5.
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Smith, GB, Gentle, AR & Arnold, MD 2022, 'Non-reciprocal emissivity, partial coherence, and amplification of internal energy from photon recycling when thermal radiation is sourced within matter'.
Solntsev, AS, Batalov, SV, Langford, NK & Sukhorukov, AA 2022, 'Coherent conversion between one and two photons in waveguides with engineered dispersion', IEEE.
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Steinig, E, Pitt, M, Aglua, I, Suttie, A, Greenhill, A, Heather, C, Firth, C, Smith, S, Pomat, W, Horwood, P, McBryde, E & Coin, L 2022, 'Genomic neighbor typing for bacterial outbreak surveillance', Cold Spring Harbor Laboratory.
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Strutt, JPB, Natarajan, M, Lee, E, Teo, DBL, Sin, W-X, Cheung, FK-W, Chew, M, Thazin, K, Barone, PW, Wolfrum, JM, Williams, RBH, Rice, SA & Springs, SL 2022, 'Machine-learning based detection of adventitious microbes in T-cell therapy cultures using long read sequencing', Cold Spring Harbor Laboratory.
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Su, D 2022, 'Powerful qua-functional electrolyte additive for lithium metal batteries', Elsevier BV, pp. 361-364.
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Lithium metal batteries (LMBs) have attracted tremendous research attention because of the high theoretical capacity (3860 mAh g−1) and the lowest electrochemical potential (−3.04 V vs standard hydrogen electrode). However, the Lithium dendrites, forming from plating/stripping processes, cause the excessive consumption of electrolyte and active Li and the puncture on the separator. This limits the commercialization of LMBs. Recently, Ma's group proposed heptafluorobutyric anhydride (HFA) as qua-functional electrolyte additive and verified the protection mechanism from the structure and electrochemical properties. Such results creatively put forward qua-functional electrolyte additive for the improvement of LMBs and provides good experience for the exploration of multi-functional additive, inspiring researchers to explore new multi-functional electrolyte additives in future.
Suyama, H, Luu, LDW, Zhong, L, Raftery, MJ & Lan, R 2022, 'Integrating proteomic data with metabolic modelling provides insight into key pathways ofBordetella pertussisbiofilms', Cold Spring Harbor Laboratory.
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Thomson, J 2022, 'How Can We Predict a Nuclear War?', Newsweek.
Tou, K, Cawley, A, Bishop, D, Bowen, C, Noble, G & Fu, S 2022, 'Complementary biomarker detection for bisphosphonate use in racehorses', Elsevier BV, pp. S23-S24.
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Aim Determining the use of off-label bisphosphonates (BPs) in young horses ( 4 years old) is of interest due to the threat to racing integrity and welfare associated with this class of drugs that have the potential to manipulate bone structure. The analysis of BPs in biological matrices is challenging by liquid chromatography coupled to mass spectrometry (LC-MS/MS) and alternative sample preparation approaches are needed to detect their misuse in racehorses. There are currently two classes of BPs: non-nitrogen and nitrogen-containing with each having a distinct mode of action. Currently two non-nitrogenous based BPs are available for use in horses, tiludronic acid (or tiludronate) and chlodronate for the treatment of navicular syndrome (Mitchell et al. BMC Veterinary Research 2019;15(1):211) in horses over the age of 4. There is, however, evidence that BPs can persist in the bone for several years after administration since they can form hydroxyapatite crystals prior to being fully absorbed by active osteoclasts where full inhibitory action is performed (Riggs et al. Equine veterinary journal 2021;53(6):1287–1295). Therefore, with this prolonged detection time for the BPs, it is necessary to investigate whether the use of metabolomic biomarkers can provide a complementary method for the detection of their misuse. The aim of this research was to develop a biomarker approach for complementary direct detection of bisphosphonate drugs in equine plasma. Method BPs are hydrophilic therefore the targeted detection of tiludronic acid in equine plasma required an orthogonal solid phase extraction (SPE) method using both a polymeric reversed-phase sorbent and a weak anion exchange cartridge prior to derivatisation using trimethyl orthoacetate and reverse LC-MS/MS. Endogenous lipids and corticosteroids in equine plasma were detected after protein precipitation and SPE with a polymeric reverse phase cartridge prior to liquid chromatography high-resolution mass spectrometry. Da
Umar, MD, Ishida, K, Murayama, R, Sari, DP, Widyaiswari, U, Fronzi, M, Rozak, H, Zaharim, WN, Watanabe, I & Iwasaki, M 2022, 'Muon-Spin Motion at the Crossover Regime between Gaussian and Lorentzian Distribution of Magnetic Fields'.
Van Eeckhoutte, HP, Donovan, C, Kim, R, Khan, H, Jayaraman, R, Dondelinger, Y, Delanghe, T, Beal, A, Geddes, B, Bertin, J, Vanden Berghe, T, Vandenabeele, P, Vanaudenaerde, B, Deforce, D, Skevin, S, Van Nieuwerburgh, F, Verhamme, F, Joos, G, Brusselle, GG, Bertrand, M, Hansbro, P & Bracke, K 2022, 'Inhibiting RIPK1 Kinase Activity Is Protective in Experimental Models of COPD', American Thoracic Society.
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Villalobos, Y, Rayner, PJ, Silver, JD, Thomas, S, Haverd, V, Knauer, J, Loh, ZM, Deutscher, NM, Griffith, DWT & Pollard, DF 2022, 'Interannual variability in the Australian carbon cycle over 2015–2019, based on assimilation of OCO-2 satellite data', Copernicus GmbH.
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Voelker, WG, Krishnan, K, Chougule, K, Alexander, LC, Lu, Z, Olson, A, Ware, D, Songsomboon, K, Ponce, C, Brenton, ZW, Boatwright, JL & Cooper, EA 2022, 'Ten new high-quality genome assemblies for diverse bioenergy sorghum genotypes', Cold Spring Harbor Laboratory.
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Walworth, NG, Espinoza, JL, Argyle, PA, Hinners, J, Levine, NM, Doblin, MA, Dupont, CL & Collins, S 2022, 'Rapid reductions in population size drive evolutionary divergence in diatoms', Cold Spring Harbor Laboratory.
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Watson, P, O'Callaghan, C, Perkes, I, Bradfield, L & Turner, K 2022, 'Making habits measurable beyond what they are not: a focus on associative dual-process models', Center for Open Science.
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Woodcock, S 2022, '433 people win a lottery jackpot – impossible? Probability and psychology suggest it’s more likely than you’d think', The Conversation.
Woodcock, S 2022, '433 people win a lottery jackpot – impossible? Probability and psychology suggest it’s more likely than you’d think', The Conversation.
Woodcock, S 2022, 'Did 433 people win the same jackpot lottery in the Philippines without cheating?', Australian Broadcasting Corporation.
Woodcock, S 2022, 'Have the NRL’s rule changes made boring blowouts the norm? The stats say no', The Conversation.
Woodcock, S 2022, 'Morocco are the first-ever African semifinalists of the World Cup. Here’s what geographical data tell us about this result', The Conversation.
Wu, X, Wang, P, Lewis, W, Jiang, Y-B & Gale, PA 2022, 'Measuring anion binding at biomembrane interfaces', American Chemical Society (ACS).
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Xu, Z, Hu, D, Wai Luu, LD, Octavia, S, Keil, AD, Sintchenko, V, Tanaka, MM, Mooi, FR, Robson, J & Lan, R 2022, 'Genomic dissection of the microevolution of Australian epidemic Bordetella pertussis', Cold Spring Harbor Laboratory.
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Yang, Y, Quiroz, M, Kohn, R & Sisson, SA 2022, 'A correlated pseudo-marginal approach to doubly intractable problems'.
Zamborain-Mason, J, Cinner, JE, MacNeil, MA, Graham, NAJ, Hoey, AS, Beger, M, Brooks, AJ, Booth, DJ, Edgar, GJ, Feary, DA, Ferse, SCA, Friedlander, AM, Gough, CLA, Green, AL, Mouillot, D, Polunin, NVC, Stuart-Smith, RD, Wantiez, L, Williams, ID, Wilson, SK & Connolly, SR 2022, 'Sustainable reference points for multispecies coral reef fisheries', Cold Spring Harbor Laboratory.
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Zeng, HZJ, Ngyuen, MAP, Ai, X, Bennet, A, Solnstev, A, Laucht, A, Al-Juboori, A, Toth, M, Mildren, R, Malaney, R & Aharonovich, I 2022, 'Integrated Room Temperature Single Photon Source for Quantum Key Distribution'.
Zhang, L, Guan, Y, Cheng, YY, Cokcetin, NN, Bottomley, AL, Robinson, A, Harry, EJ, van Oijen, A, Su, QP & Jin, D 2022, 'Fast Evolution of SOS-Independent Multi-Drug Resistance in Bacteria', Cold Spring Harbor Laboratory.
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Zhang, L, Guan, Y, Su, QP, Liao, Y, Duggin, I & Jin, D 2022, 'Induction of Bacteriophage PinR Facilitates the Evolution of Antibiotic Resistance', Cold Spring Harbor Laboratory.
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Zhanghao, K, Li, M, Chen, X, Liu, W, Li, T, Wang, Y, Su, F, Wu, Z, Shan, C, Wu, J, Zhang, Y, Fu, J, Xi, P & Jin, D 2022, 'Fast imaging of 15 intracellular compartments and interactions by deep learning segmentation of super-resolution data', Research Square Platform LLC.
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Zhigulin, I, Horder, J, Ivady, V, White, SJU, Gale, A, Li, C, Lobo, CJ, Toth, M, Aharonovich, I & Kianinia, M 2022, 'Stark effect of quantum blue emitters in hBN'.
Zhou, Q, Li, H, Gerace, D, Nikolskly, I, Wang, X, Kenty-Ryu, J, Zhang, J, Hinderhofer, M, Robinson, E & Melton, DA 2022, 'Toward Improving Immunotolerance for Stem Cell-Derived Islets', Cold Spring Harbor Laboratory.
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UTS acknowledges the Gadigal people of the Eora Nation, the Boorooberongal people of the Dharug Nation, the Bidiagal people and the Gamaygal people, upon whose ancestral lands our university stands. We would also like to pay respect to the Elders both past and present, acknowledging them as the traditional custodians of knowledge for these lands.
